Dear TCGA Community,

It is with great pleasure that we share this progress report on the
December 2010 run of the Broad GDAC pipeline.  100% success has once
again been achieved for OV, with GBM running a close second and
significant progress on 10 other tumor types and several functional
areas.  The highlights of this run include:

*  Our first stab at automated packaging for DCC upload, including:
        both data normalization outputs and analysis results
        packaged into primary and auxiliary "tarball" archives
        many with SDRFs for provenance

   We are working with the DCC to fine tune this process, but already
   have more than 400 results archives ready for access from

	caftps.nci.nih.gov:/users/gdacbroad/analysis_run_2010_12_23
	
*  Major progress automating clincal data handling:  OV has again
   received the most complete treatment, with 8 other tumor types
   nearly ready.

*  Increase to 25 the number of analyses, with the addition of:
        miR expression direct targeting
        MSKCC xvar mutation scores (the second external "module"
	to be incorporated into the pipeline, after PARADIGM)

*  Introduction of HNSC tumor type (head and neck squamous)

Please contact me directly at mnoble@broadinstiute.org if you'd like
additional details on this run.

Regards,
Mike  (on behalf of the Broad GDAC team)