Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.009 0.07 0.39 11.0 -9999.0 0.0 11.0 KIRREL 0.007 0.075 -9999.0 0.0 -0.529 10.0 10.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.01 0.07 -9999.0 0.0 -0.391 11.0 11.0 PLCG1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.01 0.066 -9999.0 0.0 -0.521 8.0 8.0 Nephrin/NEPH1/podocin/CD2AP 0.028 0.059 -9999.0 0.0 -0.274 14.0 14.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.025 0.06 -9999.0 0.0 -0.291 5.0 5.0 FYN 0.014 0.059 -9999.0 0.0 -0.254 19.0 19.0 mol:Ca2+ 0.027 0.06 -9999.0 0.0 -0.293 13.0 13.0 mol:DAG 0.028 0.06 -9999.0 0.0 -0.294 13.0 13.0 NPHS2 0.015 0.036 -9999.0 0.0 -0.431 3.0 3.0 mol:IP3 0.028 0.06 -9999.0 0.0 -0.294 13.0 13.0 regulation of endocytosis 0.028 0.058 -9999.0 0.0 -0.253 13.0 13.0 Nephrin/NEPH1/podocin/Cholesterol 0.018 0.056 -9999.0 0.0 -0.281 13.0 13.0 establishment of cell polarity 0.009 0.07 -9999.0 0.0 -0.39 11.0 11.0 Nephrin/NEPH1/podocin/NCK1-2 0.035 0.06 -9999.0 0.0 -0.311 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 0.029 0.059 -9999.0 0.0 -0.255 13.0 13.0 NPHS1 0.004 0.061 -9999.0 0.0 -0.263 25.0 25.0 Nephrin/NEPH1/podocin 0.02 0.061 -9999.0 0.0 -0.277 13.0 13.0 TJP1 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 NCK1 0.011 0.045 -9999.0 0.0 -0.276 12.0 12.0 NCK2 0.015 0.026 -9999.0 0.0 -0.254 5.0 5.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.061 -9999.0 0.0 -0.295 13.0 13.0 CD2AP 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 Nephrin/NEPH1/podocin/GRB2 0.028 0.058 -9999.0 0.0 -0.273 13.0 13.0 GRB2 0.016 0.024 -9999.0 0.0 -0.254 4.0 4.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.012 0.068 -9999.0 0.0 -0.266 24.0 24.0 cytoskeleton organization 0.029 0.063 -9999.0 0.0 -0.31 5.0 5.0 Nephrin/NEPH1 0.011 0.049 -9999.0 0.0 -0.274 11.0 11.0 Nephrin/NEPH1/ZO-1 0.019 0.066 -9999.0 0.0 -0.31 16.0 16.0