E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.071 -9999.0 0.0 -0.288 22.0 22.0 KLHL20 0.041 0.092 0.198 60.0 -0.194 21.0 81.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 73.0 73.0 Rac1/GDP 0.008 0.063 0.206 1.0 -0.242 15.0 16.0 ENAH 0.007 0.073 -9999.0 0.0 -0.309 20.0 20.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 35.0 -0.0 7.0 42.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42/GTP -0.024 0.05 0.119 11.0 -0.196 19.0 30.0 ABI1/Sra1/Nap1 -0.016 0.036 -9999.0 0.0 -0.135 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.081 0.038 -9999.0 0.0 -0.131 6.0 6.0 RAPGEF1 -0.005 0.073 0.186 1.0 -0.275 21.0 22.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 30.0 30.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.076 -9999.0 0.0 -0.289 23.0 23.0 CRK 0.002 0.075 0.179 12.0 -0.29 21.0 33.0 E-cadherin/gamma catenin/alpha catenin 0.061 0.035 -9999.0 0.0 -0.123 8.0 8.0 alphaE/beta7 Integrin 0.049 0.024 -9999.0 0.0 -0.141 6.0 6.0 IQGAP1 0.033 0.01 -9999.0 0.0 0.0 43.0 43.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 1.0 1.0 Rap1/GTP/I-afadin 0.042 0.015 -9999.0 0.0 -0.101 1.0 1.0 DLG1 0.006 0.075 -9999.0 0.0 -0.293 23.0 23.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.043 -9999.0 0.0 -0.175 28.0 28.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.101 23.0 23.0 PI3K -0.039 0.056 -9999.0 0.0 -0.225 28.0 28.0 ARF6 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 mol:Ca2+ 0.0 0.0 0.001 66.0 -0.0 25.0 91.0 E-cadherin/gamma catenin 0.047 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.033 0.01 -9999.0 0.0 0.0 43.0 43.0 E-cadherin(dimer)/Ca2+ 0.07 0.051 -9999.0 0.0 -0.14 20.0 20.0 AKT1 -0.017 0.057 0.144 11.0 -0.172 24.0 35.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 RhoA/GDP 0.012 0.071 0.237 3.0 -0.229 18.0 21.0 actin cytoskeleton organization 0.034 0.073 0.164 61.0 -0.143 21.0 82.0 CDC42/GDP 0.011 0.067 0.195 2.0 -0.228 16.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.048 -9999.0 0.0 -0.201 19.0 19.0 ITGB7 0.036 0.005 -9999.0 0.0 0.0 10.0 10.0 RAC1 0.027 0.016 -9999.0 0.0 0.0 123.0 123.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.075 0.055 -9999.0 0.0 -0.15 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.053 0.032 -9999.0 0.0 -0.111 9.0 9.0 mol:GDP -0.005 0.072 0.235 3.0 -0.26 16.0 19.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.115 32.0 32.0 JUP 0.033 0.011 -9999.0 0.0 0.0 50.0 50.0 p120 catenin/RhoA/GDP 0.025 0.077 0.249 3.0 -0.235 18.0 21.0 RAC1/GTP/IQGAP1 0.026 0.044 -9999.0 0.0 -0.117 32.0 32.0 PIP5K1C/AP1M1 0.018 0.031 -9999.0 0.0 -0.131 19.0 19.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 22.0 22.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 positive regulation of S phase of mitotic cell cycle 0.01 0.046 0.112 9.0 -0.119 33.0 42.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 28.0 28.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.008 0.073 -9999.0 0.0 -0.296 21.0 21.0 regulation of cell-cell adhesion -0.026 0.039 -9999.0 0.0 -0.164 23.0 23.0 WASF2 -0.009 0.02 -9999.0 0.0 -0.074 31.0 31.0 Rap1/GTP -0.022 0.058 0.151 16.0 -0.217 19.0 35.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.089 0.05 -9999.0 0.0 -0.129 12.0 12.0 CCND1 0.012 0.054 0.132 8.0 -0.145 33.0 41.0 VAV2 0.016 0.116 -9999.0 0.0 -0.561 11.0 11.0 RAP1/GDP -0.008 0.064 0.17 17.0 -0.239 14.0 31.0 adherens junction assembly 0.008 0.071 -9999.0 0.0 -0.288 21.0 21.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.016 -9999.0 0.0 0.0 127.0 127.0 PIP5K1C 0.032 0.012 -9999.0 0.0 0.0 58.0 58.0 regulation of heterotypic cell-cell adhesion 0.062 0.046 0.198 2.0 -0.136 12.0 14.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.092 7.0 7.0 mol:GTP 0.0 0.0 0.001 59.0 -0.0 30.0 89.0 SRC 0.006 0.072 -9999.0 0.0 -0.287 23.0 23.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 Rac1/GTP -0.009 0.077 0.177 2.0 -0.3 21.0 23.0 E-cadherin/beta catenin/alpha catenin 0.061 0.037 -9999.0 0.0 -0.134 9.0 9.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.019 0.077 -9999.0 0.0 -0.294 23.0 23.0