Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.056 -9999.0 0.0 -0.222 20.0 20.0 epithelial cell differentiation 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 73.0 73.0 ENAH -0.034 0.078 0.244 16.0 -0.233 10.0 26.0 EGFR 0.01 0.016 -9999.0 0.0 0.0 355.0 355.0 EPHA2 0.032 0.011 -9999.0 0.0 0.0 53.0 53.0 MYO6 -0.025 0.053 0.174 14.0 -0.218 11.0 25.0 CTNNB1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 ABI1/Sra1/Nap1 0.031 0.066 -9999.0 0.0 -0.126 57.0 57.0 AQP5 -0.015 0.052 0.155 14.0 -0.282 7.0 21.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 30.0 30.0 mol:PI-4-5-P2 -0.025 0.049 0.172 13.0 -0.211 10.0 23.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.05 0.172 15.0 -0.193 7.0 22.0 EGF 0.034 0.008 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 1.0 1.0 AQP3 -0.029 0.076 0.153 14.0 -0.295 28.0 42.0 cortical microtubule organization 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 GO:0000145 -0.024 0.045 0.155 13.0 -0.201 10.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.069 0.051 -9999.0 0.0 -0.14 20.0 20.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ARF6/GDP -0.049 0.039 -9999.0 0.0 -0.225 10.0 10.0 ARF6 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 Ephrin A1/EPHA2/NCK1/GIT1 0.074 0.051 -9999.0 0.0 -0.129 21.0 21.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.025 0.082 0.171 8.0 -0.285 31.0 39.0 PVRL2 0.034 0.01 -9999.0 0.0 0.0 36.0 36.0 ZYX -0.019 0.047 0.174 11.0 -0.209 12.0 23.0 ARF6/GTP 0.079 0.057 -9999.0 0.0 -0.13 20.0 20.0 CDH1 0.033 0.01 -9999.0 0.0 0.0 37.0 37.0 EGFR/EGFR/EGF/EGF 0.002 0.056 -9999.0 0.0 -0.122 58.0 58.0 RhoA/GDP 0.062 0.054 -9999.0 0.0 -0.143 24.0 24.0 actin cytoskeleton organization -0.021 0.049 0.154 12.0 -0.227 11.0 23.0 IGF-1R heterotetramer 0.032 0.012 -9999.0 0.0 0.0 56.0 56.0 GIT1 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 IGF1R 0.032 0.012 -9999.0 0.0 0.0 56.0 56.0 IGF1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 DIAPH1 -0.111 0.267 -9999.0 0.0 -0.504 133.0 133.0 Wnt receptor signaling pathway -0.062 0.049 0.139 20.0 -9999.0 0.0 20.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 RhoA/GTP -0.05 0.041 -9999.0 0.0 -0.235 11.0 11.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 VCL -0.022 0.05 0.155 12.0 -0.231 11.0 23.0 EFNA1 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 LPP -0.027 0.05 0.16 9.0 -0.236 12.0 21.0 Ephrin A1/EPHA2 0.045 0.059 -9999.0 0.0 -0.136 34.0 34.0 SEC6/SEC8 -0.04 0.028 -9999.0 0.0 -0.142 21.0 21.0 MGAT3 -0.023 0.05 0.174 15.0 -0.195 7.0 22.0 HGF/MET 0.035 0.045 -9999.0 0.0 -0.138 11.0 11.0 HGF 0.024 0.017 -9999.0 0.0 0.0 158.0 158.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.056 -9999.0 0.0 -0.223 20.0 20.0 actin cable formation -0.033 0.105 0.298 12.0 -0.292 30.0 42.0 KIAA1543 -0.021 0.04 0.15 13.0 -0.18 7.0 20.0 KIFC3 -0.026 0.048 0.174 12.0 -0.195 7.0 19.0 NCK1 0.034 0.008 -9999.0 0.0 0.0 26.0 26.0 EXOC3 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 ACTN1 -0.024 0.053 0.174 11.0 -0.222 14.0 25.0 NCK1/GIT1 0.049 0.024 -9999.0 0.0 -0.141 6.0 6.0 mol:GDP 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.03 0.055 22.0 -0.132 20.0 42.0 PIP5K1C -0.025 0.05 0.174 13.0 -0.213 10.0 23.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.016 -9999.0 0.0 0.0 127.0 127.0 ROCK1 -0.026 0.091 0.273 21.0 -0.272 6.0 27.0 adherens junction assembly -0.018 0.07 0.214 5.0 -0.263 19.0 24.0 IGF-1R heterotetramer/IGF1 0.048 0.059 -9999.0 0.0 -0.141 33.0 33.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.046 0.023 -9999.0 0.0 -0.141 3.0 3.0 MET 0.023 0.018 -9999.0 0.0 0.0 183.0 183.0 PLEKHA7 -0.026 0.03 0.055 22.0 -0.132 20.0 42.0 mol:GTP 0.071 0.05 -9999.0 0.0 -0.128 21.0 21.0 establishment of epithelial cell apical/basal polarity -0.032 0.044 0.126 20.0 -0.184 8.0 28.0 cortical actin cytoskeleton stabilization 0.009 0.056 -9999.0 0.0 -0.222 20.0 20.0 regulation of cell-cell adhesion -0.021 0.049 0.154 12.0 -0.227 11.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.056 -9999.0 0.0 -0.223 20.0 20.0