E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.024 0.071 -9999.0 0.0 -0.286 11.0 11.0 KLHL20 -0.011 0.049 0.103 9.0 -0.155 5.0 14.0 CYFIP2 -0.018 0.003 0.0 6.0 -9999.0 0.0 6.0 Rac1/GDP -0.022 0.066 0.147 9.0 -0.165 12.0 21.0 ENAH -0.036 0.089 -9999.0 0.0 -0.287 18.0 18.0 AP1M1 -0.018 0.002 0.0 2.0 -9999.0 0.0 2.0 RAP1B -0.018 0.004 0.0 7.0 -9999.0 0.0 7.0 RAP1A -0.018 0.003 0.0 6.0 -9999.0 0.0 6.0 CTNNB1 -0.015 0.007 0.0 28.0 -9999.0 0.0 28.0 CDC42/GTP -0.034 0.032 0.082 8.0 -0.11 3.0 11.0 ABI1/Sra1/Nap1 -0.021 0.025 -9999.0 0.0 -0.091 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.017 -9999.0 0.0 0.0 31.0 31.0 RAPGEF1 -0.034 0.09 0.16 8.0 -0.252 19.0 27.0 CTNND1 -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.09 -9999.0 0.0 -0.286 17.0 17.0 CRK -0.035 0.08 -9999.0 0.0 -0.275 16.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.031 0.01 -9999.0 0.0 0.0 16.0 16.0 alphaE/beta7 Integrin 0.025 0.003 -9999.0 0.0 0.0 3.0 3.0 IQGAP1 -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 NCKAP1 -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 Rap1/GTP/I-afadin 0.029 0.01 -9999.0 0.0 0.0 18.0 18.0 DLG1 -0.025 0.075 -9999.0 0.0 -0.278 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.024 0.021 -9999.0 0.0 -0.077 1.0 1.0 MLLT4 -0.018 0.004 0.0 7.0 -9999.0 0.0 7.0 ARF6/GTP/NME1/Tiam1 0.03 0.009 -9999.0 0.0 0.0 13.0 13.0 PI3K -0.029 0.025 -9999.0 0.0 -0.095 1.0 1.0 ARF6 -0.017 0.004 0.0 9.0 -9999.0 0.0 9.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.023 0.007 -9999.0 0.0 0.0 12.0 12.0 TIAM1 -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.033 0.016 -9999.0 0.0 0.0 32.0 32.0 AKT1 -0.013 0.031 0.061 11.0 -9999.0 0.0 11.0 PIK3R1 -0.018 0.004 0.0 8.0 -9999.0 0.0 8.0 CDH1 -0.017 0.004 0.0 9.0 -9999.0 0.0 9.0 RhoA/GDP -0.017 0.06 0.155 8.0 -0.159 8.0 16.0 actin cytoskeleton organization -0.008 0.038 0.084 9.0 -0.115 5.0 14.0 CDC42/GDP -0.022 0.066 0.152 9.0 -0.162 14.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.005 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 -0.018 0.001 0.0 1.0 -9999.0 0.0 1.0 RAC1 -0.017 0.004 0.0 10.0 -9999.0 0.0 10.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.017 -9999.0 0.0 0.0 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.025 0.012 -9999.0 0.0 0.0 30.0 30.0 mol:GDP -0.021 0.073 0.173 6.0 -0.177 15.0 21.0 CDC42/GTP/IQGAP1 0.022 0.005 -9999.0 0.0 0.0 9.0 9.0 JUP -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 p120 catenin/RhoA/GDP -0.024 0.06 0.153 7.0 -0.154 8.0 15.0 RAC1/GTP/IQGAP1 0.021 0.006 -9999.0 0.0 0.0 13.0 13.0 PIP5K1C/AP1M1 0.024 0.004 -9999.0 0.0 0.0 5.0 5.0 RHOA -0.016 0.006 0.0 23.0 -9999.0 0.0 23.0 CDC42 -0.018 0.003 0.0 5.0 -9999.0 0.0 5.0 CTNNA1 -0.018 0.003 0.0 5.0 -9999.0 0.0 5.0 positive regulation of S phase of mitotic cell cycle -0.005 0.022 0.064 4.0 -0.076 5.0 9.0 NME1 -0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.091 -9999.0 0.0 -0.287 19.0 19.0 regulation of cell-cell adhesion -0.034 0.019 0.038 1.0 -0.099 3.0 4.0 WASF2 -0.01 0.022 0.044 9.0 -0.068 4.0 13.0 Rap1/GTP -0.029 0.043 0.143 7.0 -0.128 2.0 9.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.006 0.026 0.073 4.0 -0.092 5.0 9.0 VAV2 -0.025 0.109 0.224 1.0 -0.31 15.0 16.0 RAP1/GDP -0.019 0.055 0.165 8.0 -0.144 1.0 9.0 adherens junction assembly -0.036 0.089 -9999.0 0.0 -0.279 19.0 19.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 PIP5K1C -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 regulation of heterotypic cell-cell adhesion -0.032 0.025 0.155 2.0 -9999.0 0.0 2.0 E-cadherin/beta catenin -0.007 0.006 -9999.0 0.0 -0.048 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.035 0.088 -9999.0 0.0 -0.282 18.0 18.0 PIK3CA -0.013 0.008 0.0 49.0 -9999.0 0.0 49.0 Rac1/GTP -0.028 0.053 -9999.0 0.0 -0.181 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.028 0.013 -9999.0 0.0 0.0 30.0 30.0 ITGAE -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.092 -9999.0 0.0 -0.291 17.0 17.0