Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.005 0.002 0.0 32.0 -9999.0 0.0 32.0 epithelial cell differentiation 0.03 0.015 -9999.0 0.0 0.0 32.0 32.0 CYFIP2 -0.018 0.003 0.0 6.0 -9999.0 0.0 6.0 ENAH -0.013 0.072 0.18 11.0 -9999.0 0.0 11.0 EGFR -0.016 0.006 0.0 20.0 -9999.0 0.0 20.0 EPHA2 -0.018 0.004 0.0 7.0 -9999.0 0.0 7.0 MYO6 -0.019 0.044 0.165 8.0 -9999.0 0.0 8.0 CTNNB1 -0.015 0.007 0.0 28.0 -9999.0 0.0 28.0 ABI1/Sra1/Nap1 0.032 0.009 -9999.0 0.0 0.0 12.0 12.0 AQP5 -0.015 0.042 0.15 7.0 -0.272 1.0 8.0 CTNND1 -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 mol:PI-4-5-P2 -0.018 0.043 0.164 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.046 0.164 9.0 -9999.0 0.0 9.0 EGF -0.018 0.003 0.0 5.0 -9999.0 0.0 5.0 NCKAP1 -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 AQP3 -0.018 0.049 0.152 6.0 -0.272 3.0 9.0 cortical microtubule organization 0.03 0.015 -9999.0 0.0 0.0 32.0 32.0 GO:0000145 -0.017 0.041 0.155 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.016 -9999.0 0.0 0.0 32.0 32.0 MLLT4 -0.018 0.004 0.0 7.0 -9999.0 0.0 7.0 ARF6/GDP -0.037 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 -0.017 0.004 0.0 9.0 -9999.0 0.0 9.0 Ephrin A1/EPHA2/NCK1/GIT1 0.034 0.018 -9999.0 0.0 0.0 37.0 37.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.033 0.158 5.0 -9999.0 0.0 5.0 PVRL2 -0.018 0.002 0.0 2.0 -9999.0 0.0 2.0 ZYX -0.018 0.044 0.165 8.0 -9999.0 0.0 8.0 ARF6/GTP 0.036 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.017 0.004 0.0 9.0 -9999.0 0.0 9.0 EGFR/EGFR/EGF/EGF -0.028 0.017 0.0 38.0 -9999.0 0.0 38.0 RhoA/GDP 0.03 0.015 -9999.0 0.0 -0.008 4.0 4.0 actin cytoskeleton organization -0.023 0.04 0.148 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 GIT1 -0.018 0.002 0.0 2.0 -9999.0 0.0 2.0 IGF1R -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 IGF1 -0.018 0.002 0.0 2.0 -9999.0 0.0 2.0 DIAPH1 0.014 0.091 -9999.0 0.0 -0.496 5.0 5.0 Wnt receptor signaling pathway -0.03 0.015 0.0 32.0 -9999.0 0.0 32.0 RHOA -0.016 0.006 0.0 23.0 -9999.0 0.0 23.0 RhoA/GTP -0.036 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 -0.018 0.003 0.0 5.0 -9999.0 0.0 5.0 VCL -0.023 0.04 0.15 8.0 -9999.0 0.0 8.0 EFNA1 -0.018 0.004 0.0 8.0 -9999.0 0.0 8.0 LPP -0.018 0.037 0.158 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 -0.031 0.015 0.0 27.0 -9999.0 0.0 27.0 SEC6/SEC8 -0.035 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.017 0.046 0.166 9.0 -9999.0 0.0 9.0 HGF/MET -0.031 0.015 0.0 25.0 -9999.0 0.0 25.0 HGF -0.018 0.003 0.0 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.005 0.002 0.0 32.0 -9999.0 0.0 32.0 actin cable formation 0.02 0.093 0.189 30.0 -0.164 1.0 31.0 KIAA1543 -0.023 0.043 0.156 8.0 -9999.0 0.0 8.0 KIFC3 -0.02 0.04 0.161 7.0 -9999.0 0.0 7.0 NCK1 -0.015 0.007 0.0 27.0 -9999.0 0.0 27.0 EXOC3 -0.015 0.007 0.0 27.0 -9999.0 0.0 27.0 ACTN1 -0.019 0.042 0.166 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.021 0.009 -9999.0 0.0 0.0 28.0 28.0 mol:GDP 0.03 0.015 -9999.0 0.0 0.0 32.0 32.0 EXOC4 -0.018 0.003 0.0 4.0 -9999.0 0.0 4.0 STX4 -0.022 0.011 0.0 32.0 -9999.0 0.0 32.0 PIP5K1C -0.018 0.044 0.165 8.0 -9999.0 0.0 8.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.018 0.002 0.0 3.0 -9999.0 0.0 3.0 ROCK1 -0.003 0.088 0.223 12.0 -9999.0 0.0 12.0 adherens junction assembly -0.023 0.066 0.153 8.0 -0.333 3.0 11.0 IGF-1R heterotetramer/IGF1 -0.032 0.014 0.0 22.0 -9999.0 0.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.024 0.006 -9999.0 0.0 0.0 9.0 9.0 MET -0.018 0.004 0.0 7.0 -9999.0 0.0 7.0 PLEKHA7 -0.017 0.046 0.166 9.0 -9999.0 0.0 9.0 mol:GTP 0.033 0.018 -9999.0 0.0 0.0 37.0 37.0 establishment of epithelial cell apical/basal polarity -0.015 0.064 0.131 23.0 -9999.0 0.0 23.0 cortical actin cytoskeleton stabilization -0.005 0.002 0.0 32.0 -9999.0 0.0 32.0 regulation of cell-cell adhesion -0.023 0.04 0.148 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.005 0.002 0.0 32.0 -9999.0 0.0 32.0