rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN2(2), AKT1(2), AKT2(2), ARHGAP5(1), BCAR1(2), BIRC2(2), BIRC3(1), BRAF(3), CCND2(1), CHAD(1), COL11A1(2), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), DIAPH1(1), DOCK1(1), EGF(1), EGFR(4), ERBB2(3), FARP2(2), FIGF(2), FLNA(2), FLNB(1), FLNC(3), FLT1(2), FN1(2), FYN(1), GRLF1(2), GSK3B(1), HGF(1), HRAS(2), ILK(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), JUN(1), KDR(2), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), MAPK10(1), MAPK9(1), MET(1), MYL7(1), MYL9(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PARVG(1), PDGFD(1), PDGFRA(3), PGF(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP5K1C(1), PRKCG(2), PTEN(11), PTK2(1), RELN(3), ROCK1(2), SOS1(4), SOS2(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TLN1(3), TLN2(4), TNC(2), TNN(2), TNR(3), TNXB(1), VAV1(1), VAV3(1), VCL(1), VEGFA(1), VTN(1), VWF(5)	181072482	223	145	223	95	26	61	92	10	34	0	<1.00e-15	<2.05e-13
2	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2S2(1), FLT1(2), FLT4(3), HIF1A(1), HRAS(2), KDR(2), NOS3(1), PIK3CA(8), PIK3R1(2), PLCG1(1), PTK2(1), VHL(102)	16366258	131	119	100	14	7	21	31	6	66	0	<1.00e-15	<2.05e-13
3	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(2), EP300(3), HIF1A(1), JUN(1), NOS3(1), VHL(102)	8099514	111	104	80	6	2	13	26	5	65	0	<1.00e-15	<2.05e-13
4	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC4(1), CDC27(1), CUL1(2), CUL3(1), FBXW11(1), FBXW7(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2E2(1), VHL(102), WWP2(1)	19910346	120	109	89	8	1	14	32	6	67	0	1.18e-14	1.45e-12
5	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTN2(2), AKT1(2), AKT2(2), ASH1L(2), CDK4(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), EPB41(1), EPB41L2(2), EPB41L3(2), EXOC4(2), F11R(1), HCLS1(1), HRAS(2), INADL(2), LLGL1(1), LLGL2(1), MAGI1(2), MAGI2(1), MAGI3(1), MLLT4(1), MPDZ(3), MRAS(1), MYH1(4), MYH10(2), MYH11(5), MYH13(2), MYH14(2), MYH2(5), MYH3(3), MYH4(2), MYH6(3), MYH7(2), MYH7B(2), MYH8(1), MYH9(2), MYL7(1), MYL9(1), PARD3(1), PARD6B(1), PPM1J(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PPP2R3A(2), PPP2R4(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PTEN(11), SPTAN1(1), TJP1(1), TJP2(1), ZAK(1)	95510705	121	100	121	61	9	38	40	6	28	0	1.19e-14	1.45e-12
6	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(2), ASH2L(1), DOT1L(2), EHMT2(2), EZH1(1), EZH2(2), FBXO11(2), HCFC1(1), HSF4(1), JMJD6(4), KDM6A(3), MLL(1), MLL2(6), MLL3(9), MLL4(2), MLL5(4), NSD1(2), OGT(3), PRDM9(2), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), RBBP5(2), SETD1A(1), SETD2(26), SETDB1(1), SETMAR(1), SUV420H1(1), SUZ12(2), WHSC1(1), WHSC1L1(4)	59129401	95	82	95	30	8	22	26	3	36	0	1.41e-14	1.45e-12
7	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN2(2), APC(5), APC2(3), ARHGEF7(1), ARPC2(1), ARPC3(1), BCAR1(2), BDKRB1(1), BRAF(3), CHRM2(1), CHRM5(2), CSK(1), CYFIP1(2), CYFIP2(1), DIAPH1(1), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(1), EGFR(4), F2(2), FGD1(3), FGF20(1), FGF6(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(1), FN1(2), GIT1(2), GNA13(1), GNG12(1), GRLF1(2), HRAS(2), IQGAP1(1), IQGAP2(1), IQGAP3(3), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGAE(2), ITGAL(2), ITGAX(1), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), LIMK2(1), MRAS(1), MSN(2), MYH10(2), MYH14(2), MYH9(2), MYL7(1), MYL9(1), MYLK(2), NCKAP1(1), NCKAP1L(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP4K2A(2), PIP5K1C(1), PPP1R12B(1), PTK2(1), ROCK1(2), SLC9A1(1), SOS1(4), SOS2(2), SSH2(2), SSH3(1), TIAM1(2), TIAM2(2), VAV1(1), VAV3(1), VCL(1), WASL(2)	137704604	152	114	152	62	14	41	68	3	26	0	1.97e-13	1.73e-11
8	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(2), EIF4G3(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), PTEN(11), RPS6KB1(2), TSC1(2), TSC2(2)	13388837	38	37	38	11	6	12	8	2	10	0	3.76e-12	2.89e-10
9	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3C3(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(2), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PTEN(11), PTPMT1(1), SYNJ1(4)	36528872	61	53	61	23	5	18	18	1	17	2	4.55e-12	3.12e-10
10	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(2), ILK(1), PDK1(1), PIK3CA(8), PIK3CD(1), PTEN(11), PTK2B(2), RBL2(1), SOS1(4)	9973858	33	32	33	8	4	10	11	1	7	0	1.59e-11	9.04e-10
11	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(2), ILK(1), ITGB1(2), PIK3CA(8), PIK3R1(2), PTEN(11), PTK2(1), SOS1(4)	9384222	33	31	33	11	7	8	11	0	7	0	1.71e-11	9.04e-10
12	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(2), CD19(1), CDKN2A(1), GAB1(1), ITPR1(1), ITPR2(4), ITPR3(1), PDK1(1), PHF11(1), PIK3CA(8), PLCG2(1), PPP1R13B(1), PREX1(3), PTEN(11), PTPRC(4), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SAG(1), SYK(1), TEC(1), VAV1(1)	27392091	52	50	52	16	6	14	16	2	14	0	1.76e-11	9.04e-10
13	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY2(1), ADCY7(1), ADCY8(4), ADCY9(2), ADORA2A(1), ADRB2(1), ATP2A1(2), ATP2A2(2), ATP2B3(1), ATP2B4(1), AVPR1A(2), BDKRB1(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1F(3), CACNA1H(3), CACNA1I(3), CACNA1S(1), CALM2(1), CAMK2G(2), CCKAR(2), CCKBR(1), CD38(1), CHRM2(1), CHRM5(2), CHRNA7(1), DRD1(1), EGFR(4), ERBB2(3), ERBB3(3), ERBB4(3), GNAL(1), GNAS(1), GRIN1(1), GRIN2A(3), GRM1(1), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), MYLK(2), NOS1(5), NOS3(1), NTSR1(1), P2RX1(1), PDE1B(2), PDE1C(1), PDGFRA(3), PHKA1(1), PHKB(2), PHKG1(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCG(2), PTAFR(1), PTGFR(1), PTK2B(2), RYR1(3), RYR2(3), RYR3(3), SLC25A4(1), SLC8A1(1), SLC8A3(1), SPHK2(1), TACR1(1), TACR2(1), TACR3(2), TRPC1(1), VDAC3(1)	134793666	145	121	145	59	14	44	59	5	23	0	5.01e-11	2.37e-09
14	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	ATM(8), ATR(4), BAI1(1), CASP8(1), CCNB2(2), CCNB3(2), CCND2(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK2(1), IGFBP3(1), LRDD(1), PTEN(11), RFWD2(3), RRM2(1), SERPINB5(2), THBS1(4), TP53(11), TP53I3(3), TSC2(2)	31385324	63	52	63	29	5	14	27	2	15	0	2.56e-10	1.12e-08
15	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2S2(1), EIF4E(1), GSK3B(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), PTEN(11), RPS6KB1(2)	9695885	30	29	30	11	7	7	7	0	9	0	5.08e-10	2.09e-08
16	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(1), IRS1(1), PABPC1(1), PIK3CA(8), PIK3R1(2), PTEN(11), RPS6KB1(2)	13691797	35	34	35	18	6	11	8	1	9	0	5.74e-10	2.21e-08
17	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(3), AKT1(2), ATM(8), CDKN1A(1), CPB2(1), HIF1A(1), IGFBP3(1), NFKBIB(1), TP53(11)	9764779	29	25	29	12	2	7	12	0	8	0	1.08e-09	3.90e-08
18	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(2), AKT2(2), ARHGAP1(1), ARHGEF11(1), ITPR1(1), ITPR2(4), ITPR3(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPP1R13B(1), PTEN(11), RACGAP1(1), ROCK1(2), SAG(1), WASL(2)	34824775	53	53	53	16	6	13	22	2	10	0	1.91e-09	6.54e-08
19	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN2(2), ARHGAP5(1), BCAR1(2), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), CTNND1(3), F11R(1), GRLF1(2), ITGAL(2), ITGB1(2), ITK(2), MLLT4(1), MSN(2), MYL7(1), MYL9(1), NCF1(1), NOX1(1), NOX3(2), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PRKCG(2), PTK2(1), PTK2B(2), PTPN11(1), RAPGEF3(2), RAPGEF4(1), RASSF5(1), ROCK1(2), VAV1(1), VAV3(1), VCAM1(1), VCL(1)	61394465	76	59	76	28	9	19	29	2	17	0	2.16e-09	6.77e-08
20	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN2(2), ACVR1B(3), ACVR1C(2), CDH1(2), CREBBP(3), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), CTNND1(3), EGFR(4), EP300(3), ERBB2(3), FARP2(2), FER(2), FGFR1(1), FYN(1), INSR(4), IQGAP1(1), LMO7(3), MAP3K7(1), MET(1), MLLT4(1), PARD3(1), PTPRB(2), PTPRF(3), PTPRJ(4), PTPRM(1), PVRL3(2), SMAD2(1), SMAD4(4), SNAI1(1), SNAI2(1), SORBS1(1), SSX2IP(1), TCF7(2), TGFBR2(2), TJP1(1), VCL(1), WASL(2)	58917089	82	69	81	29	7	26	30	6	13	0	2.20e-09	6.77e-08
21	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(2), AKT1(2), AKT2(2), ATF4(1), BRAF(3), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1F(3), CACNA1H(3), CACNA1I(3), CACNA1S(1), CACNA2D1(1), CACNB1(1), CACNG3(1), CACNG5(1), DAXX(2), DUSP10(1), DUSP3(1), DUSP8(1), ECSIT(2), EGF(1), EGFR(4), ELK4(2), FGF20(1), FGF6(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(1), FLNA(2), FLNB(1), FLNC(3), GNG12(1), HRAS(2), IL1R2(1), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(1), MAPT(1), MAX(2), MKNK2(2), MRAS(1), NF1(13), NFATC2(1), NTRK2(1), PAK1(1), PDGFRA(3), PLA2G12A(1), PLA2G6(2), PPM1A(1), PPP3CC(1), PPP5C(2), PRKACA(1), PRKACB(1), PRKCG(2), PTPN7(1), RAPGEF2(5), RASGRF1(1), RASGRF2(1), RASGRP2(2), RASGRP4(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), SOS1(4), SOS2(2), STK3(1), TAOK2(2), TAOK3(1), TGFB2(1), TGFB3(1), TGFBR2(2), TNFRSF1A(1), TP53(11), TRAF6(1), ZAK(1)	143082331	176	122	176	63	22	46	71	8	29	0	7.13e-09	2.09e-07
22	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(2), HRAS(2), PAX3(1), PML(2), RARA(2), RB1(3), SIRT1(1), SP100(1), TNFRSF1A(1), TP53(11)	9260127	29	25	29	14	1	9	14	1	4	0	8.26e-09	2.27e-07
23	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2G(1), PIK3C3(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP4K2A(2), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PRKCG(2), PTEN(11), PTPMT1(1), SYNJ1(4)	62161116	77	66	77	31	8	22	26	1	18	2	8.49e-09	2.27e-07
24	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(2), AKT2(2), CDKN2A(1), GSK3A(2), GSK3B(1), IARS(1), PDK1(1), PIK3CA(8), PPP1R13B(1), PTEN(11), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SOS1(4), SOS2(2), TEC(1), YWHAE(1)	17696060	43	37	43	14	6	11	15	1	10	0	1.50e-08	3.85e-07
25	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(2), AKT1(2), AKT2(2), ATM(8), BIRC2(2), BIRC3(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(1), CSF2RB(1), IL3(1), IRAK1(2), IRAK3(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPP3CC(1), PRKACA(1), PRKACB(1), RELA(1), RIPK1(1), TNFRSF10A(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1)	40823160	63	55	63	22	8	17	27	0	11	0	5.17e-08	1.27e-06
26	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(2), CD44(2), CHAD(1), COL11A1(2), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), FN1(2), FNDC1(2), GP1BA(1), HSPG2(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), RELN(3), SV2C(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TNC(2), TNN(2), TNR(3), TNXB(1), VTN(1), VWF(5)	109979156	116	94	116	53	17	30	42	8	19	0	9.10e-08	2.16e-06
27	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(1), ADORA2A(1), ADRB2(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(1), CHRM2(1), CHRM5(2), CNR2(1), CRHR2(1), DRD1(1), DRD5(1), F2(2), GABBR1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB3(1), GABRE(3), GABRG2(2), GABRQ(3), GABRR1(2), GABRR2(2), GH2(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GPR35(1), GPR50(1), GPR63(1), GPR83(1), GRIA1(5), GRIA2(1), GRIA4(3), GRID2(5), GRIK1(1), GRIK2(1), GRIK3(1), GRIK5(1), GRIN1(1), GRIN2A(3), GRIN2B(4), GRIN3B(2), GRM1(1), GRM2(2), GRM3(1), GRM4(1), GRM5(1), GRM7(1), GRM8(1), GZMA(1), HRH4(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), LEPR(1), LTB4R(1), MAS1(1), MC3R(1), MCHR2(3), NMBR(1), NPFFR2(1), NPY1R(1), NTSR1(1), OPRD1(1), OPRM1(1), P2RX1(1), P2RY10(2), P2RY13(1), P2RY2(1), PARD3(1), PRLR(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1), SSTR1(2), SSTR4(1), TAAR2(1), TACR1(1), TACR2(1), TACR3(2), THRA(1), TSHR(1)	107023493	128	104	128	41	12	34	59	5	18	0	1.03e-07	2.35e-06
28	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(2), TP53(11), WT1(3)	3400893	16	13	16	6	0	5	8	0	3	0	1.90e-07	4.19e-06
29	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(8), ATR(4), CHEK2(1), TP53(11)	7847444	24	21	24	16	0	7	10	1	6	0	2.87e-07	6.09e-06
30	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(8), CDC25A(1), CDK2(1), CDK4(1), RB1(3), TP53(11), WEE1(1)	8766252	26	21	26	18	0	7	12	0	7	0	5.13e-07	0.000011
31	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(2), AKT1(2), AKT2(2), BRAF(3), BTC(1), CAMK2G(2), CBL(1), CBLB(1), CDKN1A(1), EGF(1), EGFR(4), ERBB2(3), ERBB3(3), ERBB4(3), GAB1(1), GSK3B(1), HRAS(2), JUN(1), MAP2K7(1), MAPK10(1), MAPK9(1), NRG1(3), NRG2(1), NRG3(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PRKCG(2), PTK2(1), RPS6KB1(2), SOS1(4), SOS2(2), STAT5B(1)	50497577	78	63	78	31	9	25	31	1	12	0	6.43e-07	0.000013
32	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(8), ATR(4), CCNA1(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), GSK3B(1), RB1(3), TGFB2(1), TGFB3(1), TP53(11)	14731285	36	29	36	23	1	13	14	0	8	0	7.93e-07	0.000015
33	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(8), CDK2(1), CDK4(1), CDKN1A(1), PCNA(1), RB1(3), TP53(11)	9019902	26	21	26	16	0	7	12	0	7	0	1.29e-06	0.000024
34	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(2), BRAF(3), FIGF(2), HIF1A(1), PGF(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), RHEB(1), RICTOR(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), RPS6KB1(2), TSC1(2), TSC2(2), ULK3(2), VEGFA(1)	25649478	45	40	45	13	6	13	14	2	10	0	1.40e-06	0.000025
35	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), TP53(11)	3928038	16	14	16	6	0	6	7	0	3	0	1.56e-06	0.000027
36	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(2), BRD4(4), CBL(1), CDKN2A(1), GSK3A(2), GSK3B(1), IRS1(1), LNPEP(2), PARD3(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PTEN(11), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SORBS1(1), SOS1(4), SOS2(2), YWHAE(1)	28176180	53	45	53	19	9	17	15	1	11	0	2.11e-06	0.000035
37	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(1), GAB1(1), HGF(1), HRAS(2), ITGA1(1), ITGB1(2), JUN(1), MAP4K1(1), MET(1), PAK1(1), PIK3CA(8), PIK3R1(2), PTEN(11), PTK2(1), PTK2B(2), PTPN11(1), SOS1(4)	22271504	42	39	42	23	9	8	18	0	7	0	2.12e-06	0.000035
38	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(2), CDK2(1), CDKN2A(1), CREB5(1), ERBB4(3), GAB1(1), GSK3A(2), GSK3B(1), IRS1(1), MET(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PARD3(1), PDK1(1), PIK3CA(8), PIK3CD(1), PPP1R13B(1), PREX1(3), PTEN(11), PTK2(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SOS1(4), SOS2(2), TSC1(2), TSC2(2), YWHAE(1)	36771409	64	56	64	20	7	18	25	3	11	0	2.14e-06	0.000035
39	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(5), APC2(3), AXIN1(1), CACYBP(1), CAMK2G(2), CCND2(1), CHD8(1), CREBBP(3), CSNK2A2(1), CUL1(2), CXXC4(1), DKK2(1), EP300(3), FBXW11(1), FZD1(2), FZD10(1), FZD4(1), FZD5(1), GSK3B(1), JUN(1), LRP5(1), LRP6(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFAT5(1), NFATC2(1), NFATC3(2), NKD1(1), PLCB1(1), PLCB2(1), PLCB4(3), PORCN(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PPP3CC(1), PRICKLE1(1), PRKACA(1), PRKACB(1), PRKCG(2), ROCK1(2), SFRP1(2), SFRP4(1), SMAD2(1), SMAD4(4), TBL1X(1), TBL1XR1(2), TBL1Y(1), TCF7(2), TP53(11), VANGL1(1), VANGL2(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1)	78363864	92	75	90	52	1	33	37	0	21	0	2.45e-06	0.000039
40	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	AKT1(2), AKT2(2), ARHGEF7(1), BCAR1(2), BRAF(3), CDKN2A(1), CSE1L(1), DOCK1(1), EPHB2(1), FYN(1), GRB7(1), GRLF1(2), ILK(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PIK3CA(8), PIK3CB(1), PLCG1(1), PLCG2(1), PTEN(11), PTK2(1), ROCK1(2), SOS1(4), SOS2(2), TLN1(3), TLN2(4)	60131238	81	64	81	34	8	23	35	2	13	0	4.93e-06	0.000076
41	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(3), AKT1(2), AURKB(1), BMPR2(2), BUB1(1), CDKL2(1), CDS2(1), CLK2(1), CLK4(1), CSNK2A2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), INPP4A(1), INPP4B(2), INPP5A(1), ITPKA(1), ITPKB(1), MAP3K10(1), NEK3(2), OCRL(2), PAK4(2), PIK3C2G(1), PIK3CA(8), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2)	56129176	74	62	74	20	8	23	24	2	17	0	5.83e-06	0.000088
42	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(1), CADM1(1), CD22(2), CD274(1), CD34(1), CD4(1), CDH1(2), CDH2(1), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CNTN1(3), CNTNAP1(3), CNTNAP2(3), F11R(1), GLG1(2), HLA-B(1), HLA-C(1), HLA-DMB(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(3), HLA-E(1), HLA-F(1), ITGA6(2), ITGA8(1), ITGA9(2), ITGAL(2), ITGB1(2), ITGB7(1), L1CAM(1), MPZL1(1), NCAM2(2), NEGR1(2), NEO1(1), NFASC(3), NRXN1(5), NRXN2(1), NRXN3(2), PTPRC(4), PTPRF(3), PTPRM(1), PVRL3(2), SELE(3), SELP(1), SELPLG(3), VCAM1(1), VCAN(2)	71331516	94	78	94	36	14	25	35	9	11	0	9.22e-06	0.00014
43	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(2), GOT2(3), TYR(2)	2303193	9	9	9	0	1	2	2	1	3	0	0.000012	0.00017
44	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH4A1(1), AOC2(1), ARG1(1), CPS1(5), DAO(1), GATM(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), NOS1(5), NOS3(1), P4HA1(2), P4HA2(1), SMS(1)	21376576	38	35	38	10	3	9	16	3	7	0	0.000015	0.00021
45	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), ARPC3(1), PAK1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), WASL(2)	6603789	18	18	18	9	3	6	6	0	3	0	0.000021	0.00029
46	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1B(1), ADHFE1(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOX1(5), DBH(2), DCT(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), TH(1), TPO(1), TYR(2)	15283136	30	27	30	6	4	4	10	6	6	0	0.000023	0.00031
47	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), ATM(8), CASP7(1), PTK2(1), STAT1(3), TLN1(3), TP53(11)	13620350	29	25	29	15	1	9	14	0	5	0	0.000024	0.00032
48	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNGR1(1), IFNGR2(1), JAK2(2), RB1(3), RELA(1), TNFRSF1A(1), TP53(11), WT1(3)	8869567	23	20	23	14	0	8	12	0	3	0	0.000036	0.00046
49	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CDK2(1), CDK4(1), CDKN1A(1), HRAS(2), PAK1(1), PIK3CA(8), PIK3R1(2), RB1(3), RELA(1)	10015364	22	22	22	12	3	10	6	0	3	0	0.000037	0.00046
50	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), GOT1(2), GOT2(3), LDHB(1), LDHC(1), MPST(1)	3269686	10	10	10	1	1	2	3	0	4	0	0.000046	0.00056
51	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ANAPC1(3), ANAPC4(1), ATM(8), ATR(4), BUB1(1), CCNA1(2), CCNB2(2), CCNB3(2), CCND2(1), CDC14A(2), CDC25A(1), CDC27(1), CDC6(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(3), CUL1(2), EP300(3), ESPL1(3), GSK3B(1), MAD2L1(1), MCM2(3), MCM6(2), MCM7(1), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(1), PRKDC(2), RB1(3), RBL2(1), SMAD2(1), SMAD4(4), SMC1A(1), SMC1B(1), TGFB2(1), TGFB3(1), TP53(11), WEE1(1), YWHAE(1)	67464805	87	66	87	49	5	25	34	4	19	0	0.000055	0.00066
52	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(8), ATR(4), BRCA1(1), CDC25A(1), CDKN1A(1), CHEK2(1), EP300(3), PRKDC(2), RPS6KA1(1), TP53(11), WEE1(1)	21282878	34	31	34	22	0	11	14	1	8	0	0.000059	0.00070
53	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(8), BRCA1(1), CDKN1A(1), CHEK2(1), JUN(1), RAD50(4), RELA(1), TP53(11)	14500017	28	25	28	18	0	6	15	1	6	0	0.000073	0.00085
54	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(4), ATF4(1), BRAF(3), CACNA1C(5), CALM2(1), CAMK2G(2), CREBBP(3), EP300(3), GRIA1(5), GRIA2(1), GRIN1(1), GRIN2A(3), GRIN2B(4), GRM1(1), GRM5(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), PLCB1(1), PLCB2(1), PLCB4(3), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCG(2), RAPGEF3(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3)	50350448	64	58	64	26	4	22	23	2	13	0	0.000077	0.00088
55	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(5), CACNA1D(4), CACNA1F(3), CACNA1S(1), CALM2(1), CAMK2G(2), EGFR(4), GNAS(1), GNRH2(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K3(1), MAP3K4(3), MAPK10(1), MAPK9(1), PLA2G12A(1), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB4(3), PLD1(1), PLD2(1), PRKACA(1), PRKACB(1), PRKCD(2), PTK2B(2), SOS1(4), SOS2(2)	63917816	75	65	75	23	5	21	35	1	13	0	0.000082	0.00092
56	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(5), AXIN1(1), FZD1(2), GSK3B(1), IRAK1(2), LBP(2), PIK3CA(8), PIK3R1(2), PPP2CA(2), RELA(1), TLR4(1)	14626234	29	28	29	15	4	10	11	0	4	0	0.00011	0.0012
57	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	CHAD(1), COL11A1(2), COL17A1(1), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), DSC2(1), DSC3(1), DSG1(2), DSG2(1), DSG3(1), DSG4(1), FN1(2), GJA4(1), GJA8(1), GJB6(1), GJC2(1), GJD2(1), GJD4(1), ITGA6(2), KRT1(4), KRT12(1), KRT13(1), KRT15(2), KRT16(1), KRT18(1), KRT2(1), KRT28(1), KRT31(1), KRT33A(1), KRT35(1), KRT36(2), KRT4(2), KRT6B(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT78(1), KRT79(2), KRT82(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), LMNB1(1), RELN(3), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TNC(2), TNN(2), TNR(3), TNXB(1), VTN(1), VWF(5)	120220440	138	98	136	55	18	33	52	8	27	0	0.00011	0.0012
58	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(2), AKT2(2), CBL(1), CBLB(1), CCND2(1), CREBBP(3), CSF2RB(1), CSF3R(1), EP300(3), GH2(1), GHR(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL19(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL2RB(1), IL3(1), IL4R(1), IL6R(1), IL6ST(2), IRF9(1), JAK1(2), JAK2(2), JAK3(1), LEPR(1), LIFR(1), PIAS1(2), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PRLR(1), PTPN11(1), SOS1(4), SOS2(2), SPRED1(2), SPRY2(1), STAM(1), STAT1(3), STAT2(1), STAT4(2), STAT5B(1), STAT6(2), TPO(1), TYK2(2)	69514730	88	72	88	31	11	36	30	2	9	0	0.00012	0.0013
59	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(4), POLR2A(4), PPP2CA(2), RB1(3), TERT(1), TNKS(1), TP53(11), XRCC5(1)	13830155	29	24	29	13	2	11	11	0	5	0	0.00012	0.0013
60	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CREBBP(3), ELSPBP1(1), F2(2), GATA4(1), GSK3B(1), HRAS(2), MYH2(5), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PPP3CC(1), PRKACB(1), RPS6KB1(2)	24527285	38	37	38	14	5	12	13	0	8	0	0.00014	0.0015
61	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(1), PIK3CA(8), PIK3R1(2), POLR1A(1), POLR1C(1), RB1(3), TP53(11)	9750464	27	21	27	16	3	12	8	0	4	0	0.00016	0.0016
62	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	HLA-DRA(1), HLA-DRB1(3), ITK(2), PIK3CA(8), PIK3R1(2), PTPN11(1)	6139444	17	15	17	8	3	7	3	1	3	0	0.00017	0.0017
63	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GBA3(1), GGT1(2), SHMT1(1), SHMT2(2)	2824354	8	8	8	2	0	1	4	1	2	0	0.00017	0.0017
64	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(1), AGMAT(2), ALDH18A1(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), ARG1(1), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(1), SAT1(1), SAT2(1), SMS(1)	14578957	26	26	26	8	1	6	14	3	2	0	0.00018	0.0017
65	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(1), FUCA2(1), GBA(2), GLB1(3), GNS(1), GUSB(2), HEXA(1), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(1), MAN2B2(2), MAN2C1(4), NAGLU(1), SPAM1(2)	16850879	31	27	31	6	3	10	10	3	5	0	0.00019	0.0018
66	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(3), DAXX(2), HRAS(2), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAP4K5(3), MAPK10(1), MAPK4(1), MAPK9(1), MAPKAPK5(1), MAX(2), MEF2A(1), MKNK2(2), PAK1(1), RELA(1), RIPK1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), STAT1(3), TGFB2(1), TGFB3(1), TRADD(1)	47551987	54	47	54	14	7	13	20	0	14	0	0.00021	0.0020
67	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), DPM2(1), HRAS(2), KLK2(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4)	7666611	21	19	21	6	4	10	6	0	1	0	0.00021	0.0020
68	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1B(1), ADH5(1), ADHFE1(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOX1(5), DBH(2), DCT(1), DDC(2), GOT1(2), GOT2(3), LCMT2(1), MAOA(1), MAOB(1), MYST3(4), PNPLA3(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TH(1), TPO(1), TYR(2), TYRP1(1)	28874502	43	37	43	9	6	7	17	6	7	0	0.00024	0.0021
69	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CARS2(1), GOT1(2), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(1), MPST(1), SULT4A1(1)	6120236	13	13	13	1	1	2	4	0	6	0	0.00025	0.0022
70	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), MPO(3), PRDX1(1), PRDX5(1), TPO(1)	10813926	22	19	22	2	2	5	8	4	3	0	0.00026	0.0023
71	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(2), GSK3A(2), GSK3B(1), IL4R(1), IRS1(1), JAK1(2), JAK3(1), MAP4K1(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PPP1R13B(1), SOS1(4), SOS2(2), STAT6(2)	17350469	34	30	34	7	7	10	12	1	4	0	0.00027	0.0023
72	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(8), BUB1(1), CCNA1(2), CCNB2(2), CCNB3(2), CCND2(1), CDAN1(1), CDC14A(2), CDC25A(1), CDC6(1), CDH1(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK2(1), DTX4(1), EP300(3), ESPL1(3), GSK3B(1), HDAC4(1), MAD2L1(1), MCM2(3), MCM6(2), MCM7(1), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(1), PRKDC(2), PTPRA(1), RB1(3), SMAD4(4), TBC1D8(1), TP53(11), WEE1(1)	55165539	72	57	72	43	4	19	31	3	15	0	0.00027	0.0023
73	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASS1(1), CPS1(5), DAO(1), EPRS(1), GATM(2), GOT1(2), GOT2(3), LAP3(2), NOS1(5), NOS3(1), P4HA1(2), P4HA2(1), PARS2(1)	17335384	29	27	29	10	2	8	13	0	6	0	0.00028	0.0024
74	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(3), CACNA1A(1), GNA13(1), GNAO1(1), GNAS(1), GNAZ(1), GRIA1(5), GRIA2(1), GRID2(5), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), NOS1(5), NOS3(1), NPR1(3), NPR2(1), PLA2G12A(1), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB4(3), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(3)	54982218	64	58	64	34	4	23	25	2	10	0	0.00029	0.0024
75	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP6(1), BMP7(1), BMP8B(1), CSNK1G1(1), CSNK1G2(1), FBXW11(1), GLI2(3), GLI3(2), GSK3B(1), HHIP(2), LRP2(7), PRKACA(1), PRKACB(1), PTCH1(2), PTCH2(1), SMO(2), STK36(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1)	29022754	35	35	35	14	0	12	18	2	3	0	0.00030	0.0025
76	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BIRC2(2), BIRC3(1), CASP2(1), CASP7(1), CASP8(1), JUN(1), MAP3K1(1), MAPK10(1), PARP1(2), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1)	18248756	27	25	27	9	3	5	12	1	6	0	0.00038	0.0031
77	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	HRAS(2), JAK1(2), JUN(1), MAP3K1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3)	17090651	27	26	27	14	4	10	7	0	6	0	0.00039	0.0031
78	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(3)	1287858	5	5	5	0	1	1	1	0	2	0	0.00041	0.0031
79	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(2), CDKN1A(1), HRAS(2), PIK3CA(8), PIK3CD(1), SOS1(4)	7972438	20	19	20	2	2	10	7	0	1	0	0.00041	0.0031
80	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(8), ATR(4), BRCA1(1), BRCA2(2), CHEK2(1), FANCE(3), FANCF(1), FANCG(1), RAD50(4), TP53(11)	21731805	36	32	36	19	0	11	17	1	7	0	0.00041	0.0031
81	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(1), EIF2S2(1), RELA(1), TP53(11)	5017925	14	12	14	4	1	3	8	0	2	0	0.00042	0.0031
82	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GLB1(3), GNS(1), GUSB(2), HEXA(1), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(1), NAGLU(1), SPAM1(2)	10147121	22	20	22	3	3	7	5	3	4	0	0.00042	0.0031
83	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), EGFR(4), ERBB2(3), ERBB4(3), ETV6(1), FMN2(7), NOTCH1(6), NOTCH2(2), NOTCH3(2), PIWIL2(1), SOS1(4), SOS2(2), SPIRE1(1), SPIRE2(1)	24526885	40	37	40	18	2	11	18	1	8	0	0.00046	0.0034
84	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(8), CCNA1(2), CCND2(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), GBA2(3), MCM2(3), MCM6(2), MCM7(1), MNAT1(1), NACA(2), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), POLE(1), POLE2(1), RB1(3), RPA3(1), TFDP2(3), TNXB(1), TP53(11), WEE1(1)	36743213	55	45	55	30	4	16	24	1	10	0	0.00047	0.0035
85	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(2), PTPRU(2), STAT1(3), STAT2(1), TYK2(2)	6164882	12	12	12	3	1	5	2	1	3	0	0.00051	0.0036
86	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(2), INPP5A(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(2), PIK3C2G(1), PIK3CA(8), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCG1(1), PLCG2(1)	22215854	31	27	31	10	2	12	8	0	9	0	0.00051	0.0036
87	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), BMPR1B(1), CCND2(1), CDK4(1), EGR1(1), GJA4(1), MLH1(1), NCOR1(2), NRIP1(4), PGR(1), PRLR(1), PTGER2(1), SMPD1(1), VDR(1)	16906629	25	24	25	7	0	7	11	2	5	0	0.00052	0.0037
88	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(2), CARD11(3), CBL(1), CBLB(1), CD4(1), CDK4(1), FYN(1), HRAS(2), ITK(2), JUN(1), MALT1(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PPP3CC(1), PRKCQ(2), PTPRC(4), SOS1(4), SOS2(2), TEC(1), VAV1(1), VAV3(1), ZAP70(1)	49632734	63	56	63	21	7	26	23	1	6	0	0.00057	0.0040
89	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(3), AKT1(2), AKT2(2), BRAF(3), CALM2(1), CBL(1), CBLB(1), FBP1(1), GSK3B(1), GYS1(2), GYS2(1), HRAS(2), INSR(4), IRS1(1), LIPE(2), MAPK10(1), MAPK9(1), MKNK2(2), PCK1(2), PDE3A(2), PDE3B(1), PFKM(2), PHKA1(1), PHKB(2), PHKG1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPARGC1A(3), PPP1R3A(1), PPP1R3D(1), PRKACA(1), PRKACB(1), PRKAG1(2), PRKAG2(1), PRKCI(1), PRKCZ(1), PTPRF(3), RHEB(1), RPS6KB1(2), SORBS1(1), SOS1(4), SOS2(2), TSC1(2), TSC2(2)	77264356	87	73	87	32	10	31	32	3	11	0	0.00061	0.0042
90	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(2), SHMT1(1), SHMT2(2)	2108602	6	6	6	0	0	0	3	1	2	0	0.00061	0.0042
91	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(2), GHR(1), HRAS(2), PIK3CA(8), PIK3R1(2)	6466242	17	16	17	5	3	8	5	0	1	0	0.00073	0.0049
92	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(5), GLS(1), GOT1(2)	3745761	9	9	9	0	0	3	3	0	3	0	0.00081	0.0054
93	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1B(3), ACVR1C(2), ACVR2A(1), AMHR2(2), BMP2(1), BMP4(1), BMP6(1), BMP7(1), BMP8B(1), BMPR1B(1), BMPR2(2), CHRD(1), CREBBP(3), CUL1(2), DCN(2), EP300(3), INHBE(1), LTBP1(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), RBL2(1), ROCK1(2), RPS6KB1(2), SMAD2(1), SMAD4(4), SMAD9(2), SMURF2(2), TGFB2(1), TGFB3(1), TGFBR2(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), ZFYVE16(2), ZFYVE9(3)	48527294	64	55	64	17	8	19	22	3	12	0	0.00084	0.0056
94	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(8), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(1)	6355990	15	15	15	7	3	6	4	0	2	0	0.00093	0.0061
95	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(2), CALM2(1), GNAS(1), GNB1(2), NOS3(1), PIK3CA(8), PIK3R1(2), RELA(1)	8618018	19	19	19	7	3	9	6	0	1	0	0.00095	0.0061
96	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(2), STAT1(3), STAT2(1), TYK2(2)	5284693	10	10	10	3	0	4	2	1	3	0	0.00099	0.0064
97	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(2), IARS(1), IL4R(1), JAK1(2), JAK2(2), JAK3(1), PIK3CA(8), PPP1R13B(1), RPS6KB1(2), SERPINA4(1), SOS1(4), SOS2(2), STAT6(2), TYK2(2)	18184542	33	28	33	6	4	11	11	1	6	0	0.0011	0.0068
98	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), FBP1(1), GOT1(2), GOT2(3), GPT2(1), MDH1(1), ME1(1), ME2(1), ME3(1), PGK1(3)	8643968	15	15	15	3	2	4	4	2	3	0	0.0011	0.0071
99	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(3), CALM2(1), CDKN1A(1), CREBBP(3), EGR2(1), EGR3(1), EP300(3), GATA4(1), GRLF1(2), GSK3A(2), GSK3B(1), HRAS(2), IFNB1(1), IL3(1), ITK(2), JUNB(2), MAP2K7(1), MAPK9(1), MEF2A(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), NPPB(1), NUP214(1), OPRD1(1), PAK1(1), PPP3CC(1), PTPRC(4), RELA(1), TRPV6(1), VAV1(1), VAV3(1), XPO5(1)	44261565	49	47	49	19	6	16	20	1	6	0	0.0011	0.0072
100	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(2), CR2(2), HLA-DRA(1), HLA-DRB1(3), ITGAL(2), PTPRC(4)	7337450	14	13	14	5	2	2	5	1	4	0	0.0013	0.0077
101	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), HRAS(2), JAK2(2), JUN(1), MAP3K1(1), PIK3CA(8), PIK3R1(2), SOS1(4), STAT1(3), STAT5B(1)	13510281	26	25	26	7	4	12	8	0	2	0	0.0014	0.0082
102	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(2), CASP8(1), CXCL11(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IRAK1(2), JUN(1), LBP(2), MAP2K3(2), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK9(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), RELA(1), RIPK1(1), STAT1(3), TICAM1(2), TICAM2(1), TLR1(1), TLR4(1), TLR6(1), TLR7(1), TLR8(2), TRAF3(1), TRAF6(1)	43683662	55	49	55	16	8	21	17	0	9	0	0.0014	0.0085
103	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), FBP1(1), GOT1(2), GOT2(3), GPT2(1), MDH1(1), ME1(1), ME3(1), PGK1(3), TKTL2(2)	9676635	16	16	16	4	2	4	5	2	3	0	0.0014	0.0085
104	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), HRAS(2), JUN(1), KLK2(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4)	9282291	20	19	20	5	4	9	6	0	1	0	0.0015	0.0087
105	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), GHR(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), RELA(1)	6958353	16	16	16	4	3	8	3	0	2	0	0.0016	0.0094
106	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(3), PTPRC(4), ZAP70(1)	4341535	11	10	11	5	1	4	3	1	2	0	0.0018	0.011
107	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), ITGB1(2), KLRC1(1), PAK1(1), PIK3CA(8), PIK3R1(2), PTK2B(2), SYK(1), VAV1(1)	9192726	19	19	19	6	4	7	4	0	4	0	0.0019	0.011
108	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), CBL(1), HRAS(2), IL2RB(1), IRS1(1), JAK1(2), JAK3(1), PIK3CA(8), PIK3R1(2), RPS6KB1(2), SOS1(4), STAT5B(1), SYK(1)	17458648	28	27	28	10	5	10	7	0	6	0	0.0021	0.012
109	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), MPO(3), MYST3(4), PNPLA3(1), TPO(1)	16770427	25	22	25	4	2	7	9	4	3	0	0.0022	0.012
110	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(4), ERBB3(3), NRG1(3)	5030470	11	11	11	2	2	3	4	0	2	0	0.0022	0.012
111	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), C1QA(1), C1QC(1), C1S(1), C3(4), C3AR1(1), C4BPA(1), C5(4), C6(2), C7(2), C8A(1), C9(1), CD55(1), CFB(1), CFH(2), CPB2(1), CR1(2), CR2(2), F12(1), F13A1(1), F2(2), F5(3), F8(1), FGA(1), MASP2(1), PLAT(2), PLAU(3), PLG(1), PROC(2), SERPINA1(1), SERPIND1(1), SERPINF2(1), SERPING1(2), TFPI(1), VWF(5)	44176232	61	51	61	20	2	22	28	1	8	0	0.0022	0.012
112	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(3), EP300(3), FYN(1), JAK1(2), JAK3(1), PIK3CA(8), PIK3R1(2), PTK2B(2), STAT5B(1)	13838858	23	22	23	12	4	7	7	0	5	0	0.0023	0.013
113	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ADRB2(1), ANXA6(2), ATP1A4(2), ATP2A2(2), ATP2B3(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1S(1), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2G(2), CASQ1(1), CASQ2(1), CHRM2(1), CHRM5(2), GJA4(1), GJB6(1), GNAO1(1), GNAZ(1), GNB1(2), GNG12(1), GNG3(1), GRK6(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), MYCBP(1), PKIA(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), RGS17(1), RGS18(1), RGS2(1), RGS3(3), RGS9(1), RYR1(3), RYR2(3), RYR3(3), SLC8A1(1), SLC8A3(1)	94915598	95	79	95	33	8	31	35	2	19	0	0.0023	0.013
114	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADSL(1), AK2(1), AK5(1), ALLC(1), AMPD3(1), ATP5A1(1), ATP5G2(1), ENPP3(2), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), IMPDH1(1), IMPDH2(2), NPR1(3), NPR2(1), PAPSS2(1), PDE4A(2), PDE4C(4), PDE5A(1), PDE6C(2), PDE8A(1), PFAS(1), POLD1(2), POLE(1), POLL(1), POLQ(3), POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2(1)	63445862	63	55	63	11	11	15	20	3	14	0	0.0024	0.013
115	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), ATF5(1), ATP2A2(2), CALM2(1), CAMK2G(2), CNN2(1), DGKZ(1), GABPA(1), GBA2(3), GNB1(2), GNG12(1), GNG3(1), GRK6(1), GUCA2A(1), GUCY1A3(2), IGFBP3(1), ITPR1(1), ITPR2(4), ITPR3(1), JUN(1), NOS1(5), NOS3(1), PKIA(1), PLCD1(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP3(1), RGS17(1), RGS18(1), RGS2(1), RGS3(3), RGS9(1), RLN1(1), RYR1(3), RYR2(3), RYR3(3), SLC8A1(1), TNXB(1)	85419334	84	72	84	28	10	22	40	1	11	0	0.0025	0.013
116	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(2), CARD11(3), CD19(1), CD22(2), CR2(2), GSK3B(1), HRAS(2), JUN(1), LILRB3(3), MALT1(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG2(1), PPP3CC(1), SYK(1), VAV1(1), VAV3(1)	36383678	46	40	46	16	5	19	14	0	8	0	0.0025	0.013
117	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), MUSK(1), PIK3CA(8), PIK3R1(2), PTK2(1), PTK2B(2), TERT(1)	8189082	17	17	17	7	3	8	4	0	2	0	0.0026	0.013
118	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(4), GNAS(1), GNB1(2), HRAS(2), ITGB1(2), KLK2(1), MKNK2(2), PDGFRA(3), PPP2CA(2), RPS6KA1(1), SOS1(4)	16247220	25	24	25	8	3	8	11	0	3	0	0.0027	0.014
119	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	CREBBP(3), EP300(3), HSD17B4(1), JUN(1), ME1(1), NCOA1(1), NCOR1(2), NCOR2(3), NR1H3(1), NRIP1(4), PIK3CA(8), PIK3R1(2), PRKACB(1), PTGS2(2), RB1(3), RELA(1), STAT5B(1)	30400235	38	36	38	20	3	13	17	0	5	0	0.0029	0.015
120	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(1), EGFR(4), HRAS(2), JAK1(2), JUN(1), MAP3K1(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3)	18379052	29	27	29	11	5	12	7	0	5	0	0.0030	0.015
121	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(1), DLL1(1), FZD1(2), GSK3B(1), NOTCH1(6)	9575567	16	16	16	10	1	3	9	0	3	0	0.0030	0.015
122	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(5), AXIN1(1), CCND2(1), FZD1(2), FZD10(1), FZD5(1), GSK3B(1), JUN(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(3), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(3), SFRP4(1), TCF7(2), WNT5B(1), WNT7B(1)	28540264	37	34	36	22	2	14	15	0	6	0	0.0031	0.016
123	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1)	6324134	14	13	14	0	0	3	9	1	1	0	0.0034	0.017
124	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), CES1(3)	2863414	8	8	8	1	1	2	2	3	0	0	0.0034	0.017
125	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(2), FYN(1), GAB2(1), HRAS(2), IL3(1), MAP2K3(2), MAP2K7(1), MAPK10(1), MAPK9(1), PDK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLA2G12A(1), PLA2G6(2), PLCG1(1), PLCG2(1), PRKCD(2), SOS1(4), SOS2(2), SYK(1), VAV1(1), VAV3(1)	35248653	47	39	47	16	7	13	20	1	6	0	0.0034	0.017
126	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), MPO(3), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(1)	5834910	12	12	12	0	1	2	8	0	1	0	0.0034	0.017
127	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CHN1(2), MAP3K1(1), MYLK(2), PAK1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLD1(1), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(1), VAV1(1)	17220568	27	26	27	10	6	7	6	1	7	0	0.0035	0.017
128	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(2), ANKRD6(1), APC(5), AXIN1(1), DACT1(2), DKK2(1), FSTL1(1), GSK3A(2), GSK3B(1), LRP1(5), MVP(1), NKD1(1), PTPRA(1), SFRP1(2)	19769296	28	26	27	13	2	7	12	1	6	0	0.0037	0.018
129	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(5), AR(1), BRAF(3), EGFR(4), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), MAPK10(1), PIK3CA(8), PIK3CD(1), PIK3R1(2)	26491684	39	34	39	20	5	15	11	1	7	0	0.0041	0.020
130	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), MAP2K3(2), MAP3K1(1), PIK3CA(8), PIK3R1(2), RB1(3), RELA(1)	9680783	19	17	19	11	4	8	4	0	3	0	0.0043	0.020
131	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), HRAS(2), MEF2A(1), PIK3CA(8), PIK3R1(2), PLCG1(1), RPS6KA1(1)	9593470	17	17	17	5	3	7	5	0	2	0	0.0050	0.024
132	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), DRD1(1), EGF(1), EGFR(4), GJD2(1), GNAS(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), HRAS(2), HTR2A(1), HTR2C(1), ITPR1(1), ITPR2(4), ITPR3(1), NPR1(3), NPR2(1), PDGFD(1), PDGFRA(3), PLCB1(1), PLCB2(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(4), SOS2(2), TJP1(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1)	65019970	68	60	68	29	8	22	25	1	12	0	0.0051	0.024
133	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), HRAS(2), IRS1(1), PIK3CA(8), PIK3R1(2), SOS1(4)	9128234	19	18	19	7	4	8	6	0	1	0	0.0051	0.024
134	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CDH1(2), CREBBP(3), EP300(3), MAP3K7(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(2)	12682942	19	19	19	13	3	4	8	0	4	0	0.0055	0.025
135	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), DLAT(2), FBP1(1), GAPDHS(2), GOT1(2), GOT2(3), GPI(1), HK1(3), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PCK1(2), PDHX(1), PFKM(2), PGAM1(1), PGK1(3)	20479664	28	25	28	6	1	7	9	4	7	0	0.0057	0.026
136	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(1), ADRB2(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CCKAR(2), CCKBR(1), CHML(1), CHRM2(1), CHRM5(2), CMKLR1(1), CNR2(1), DRD1(1), DRD5(1), GPR17(1), GPR173(2), GPR174(3), GPR35(1), GPR50(1), GPR63(1), GPR83(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), LTB4R(1), MAS1(1), MC3R(1), NMBR(1), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(1), OPRM1(1), OR12D3(1), OR1F1(1), OR5V1(1), OR7A5(1), OR8B8(1), P2RY10(2), P2RY13(1), P2RY2(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1), SSTR1(2), SSTR4(1)	57449655	58	54	58	16	4	16	30	1	7	0	0.0059	0.027
137	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(3)	1043406	5	4	5	3	0	2	1	1	1	0	0.0060	0.027
138	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1D(1), EIF2AK1(3), EIF2AK2(2), EIF2AK3(1), EIF2B1(2), EIF2B2(1), EIF2S2(1), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G3(1), EIF5(2), EIF5A(1), ETF1(3), KIAA0664(2), PABPC1(1), PABPC3(3), SLC35A4(2)	21641122	31	29	31	12	6	9	9	2	5	0	0.0061	0.027
139	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), BRAF(3), CREB5(1), CREBBP(3), EGR1(1), EGR2(1), EGR3(1), FRS2(2), JUN(1), MAP1B(1), MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), PIK3C2G(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PTPN11(1), RPS6KA3(1), TH(1)	25106623	36	34	36	16	5	11	14	1	5	0	0.0063	0.028
140	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	F2(2), GNA13(1), GNB1(2), MAP3K7(1), PIK3CA(8), PIK3R1(2), PLCB1(1), PPP1R12B(1), PTK2B(2), ROCK1(2)	12669992	22	22	22	6	4	9	4	0	5	0	0.0063	0.028
141	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1)	8609056	16	15	16	1	0	3	11	1	1	0	0.0067	0.029
142	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(4), C5(4), C6(2), C7(2), ITGAL(2), ITGB1(2), SELP(1), SELPLG(3), VCAM1(1)	12196641	21	20	21	3	1	3	13	2	2	0	0.0069	0.030
143	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), DUSP10(1), DUSP8(1), GAB1(1), JUN(1), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFATC3(2), NR2C2(1), TP53(11), TRAF6(1), ZAK(1)	24567523	36	31	36	9	3	13	12	0	8	0	0.0069	0.030
144	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(3), G6PD(1), GGT1(2), GPX3(3), GSS(1), IDH1(1), IDH2(1), OPLAH(1), TXNDC12(1)	10517621	14	14	14	5	1	4	6	0	3	0	0.0070	0.030
145	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(2), GCA(1), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), PAK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), RIPK3(1)	24375423	30	29	30	9	4	11	10	1	4	0	0.0075	0.032
146	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(1), NDUFA13(3)	2046493	6	6	6	0	0	0	5	1	0	0	0.0076	0.032
147	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	AKT1(2), GNB1(2), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLCB1(1), PTK2(1), SMPD1(1)	13385405	20	20	20	16	3	7	6	0	4	0	0.0081	0.034
148	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CD4(1), CD74(1), CIITA(1), CTSB(2), CTSL1(1), HLA-B(1), HLA-C(1), HLA-DMB(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(3), HLA-E(1), HLA-F(1), HSP90AA1(3), HSP90AB1(1), HSPA5(2), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), KLRC1(1), TAP1(1), TAP2(1)	21291644	32	29	32	12	5	12	8	3	4	0	0.0083	0.035
149	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(2), HRAS(2), HSPB2(1), MAP3K1(1), MAP3K5(1), MAP3K7(1), MAPKAPK5(1), MAX(2), MEF2A(1), RIPK1(1), STAT1(3), TGFB2(1), TGFB3(1), TRADD(1)	18158506	19	19	19	2	3	7	3	0	6	0	0.0084	0.035
150	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), IFNGR2(1), JAK1(2), JAK2(2), STAT1(3)	4048587	9	8	9	1	0	5	2	0	2	0	0.0085	0.035
151	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), MPO(3), MTHFR(1), SHMT1(1), SHMT2(2), TPO(1)	5734934	11	11	11	0	1	2	7	0	1	0	0.0086	0.035
152	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDK2(1), CUL1(2), FBXW7(3), RB1(3)	4196502	9	8	9	8	0	2	4	0	3	0	0.0090	0.036
153	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), AKAP10(1), AKAP11(1), AKAP7(1), AKAP9(4), CALM2(1), CHMP1B(1), GNA13(1), GNAL(1), GNAO1(1), GNAZ(1), GNB1(2), GNG12(1), GNG3(1), HRAS(2), IL18BP(1), ITPR1(1), KCNJ3(3), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(4), PDE8A(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(3), PRKD3(2), SLC9A1(1)	57930118	64	56	64	25	8	18	25	2	11	0	0.0090	0.036
154	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	HRAS(2), INSR(4), IRS1(1), JUN(1), PIK3CA(8), PIK3R1(2), PTPN11(1), SOS1(4)	12349616	23	21	23	8	4	9	8	1	1	0	0.0094	0.038
155	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), HRAS(2), INSR(4), IRS1(1), JAK2(2), PIK3CA(8), PIK3R1(2), PLCG1(1), RPS6KA1(1), SOS1(4), STAT5B(1)	16067800	27	25	27	9	4	11	10	1	1	0	0.0099	0.039
156	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD4(1), CREBBP(3), CSK(1), GNAS(1), GNB1(2), HLA-DRA(1), HLA-DRB1(3), PRKACB(1), PTPRC(4), ZAP70(1)	11034545	18	16	18	7	1	6	8	1	2	0	0.010	0.040
157	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD4(1), CREBBP(3), CSK(1), GNAS(1), GNB1(2), HLA-DRA(1), HLA-DRB1(3), PRKACB(1), PTPRC(4), ZAP70(1)	11034545	18	16	18	7	1	6	8	1	2	0	0.010	0.040
158	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CDK2(1), CUL1(2), RB1(3)	4308009	8	8	8	6	0	3	2	0	3	0	0.010	0.041
159	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), AKT1(2), AKT2(2), CAMKK1(1), CAMKK2(2), IRS1(1), JAK1(2), JAK2(2), JAK3(1), LEPR(1), MAPK10(1), MAPK9(1), NFKBIB(1), NPY(1), PCK1(2), POMC(1), PPARGC1A(3), PRKAG1(2), PRKAG2(1), PRKCQ(2), PTPN11(1), RELA(1), RXRB(1), RXRG(2), TNFRSF1A(1), TRADD(1), TYK2(2)	39820344	43	41	43	17	4	14	18	2	5	0	0.011	0.043
160	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(3), ACSS1(2), ACSS2(2), IDH1(1), IDH2(1), MDH1(1)	6525575	13	12	13	7	1	2	8	0	2	0	0.012	0.047
161	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	HRAS(2), JAK2(2), JUN(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3), STAT5B(1)	14736662	24	23	24	9	4	11	8	0	1	0	0.012	0.047
162	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(2), DMD(6), MYBPC1(1), MYBPC2(1), MYBPC3(2), MYH3(3), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL9(1), MYOM1(3), NEB(7), TMOD1(1), TNNT1(1), TNNT2(1), TNNT3(1), TTN(39)	69036756	77	64	77	24	15	27	25	1	9	0	0.013	0.050
163	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), FPGS(2)	3096940	8	7	8	3	0	1	5	1	1	0	0.014	0.051
164	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), LDHB(1), LDHC(1), NCL(3)	4342884	9	9	9	3	2	2	2	1	2	0	0.014	0.051
165	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PDXP(1)	2380775	6	6	6	0	1	1	2	1	1	0	0.014	0.052
166	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), GNB1(2), HRAS(2), PIK3C2G(1), PIK3CA(8), PIK3R1(2), PLCG1(1), PTK2(1), PTK2B(2), RELA(1)	13763386	22	21	22	10	3	7	9	0	3	0	0.015	0.054
167	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	GOT1(2), GOT2(3), PAH(1), YARS2(1)	4268604	7	7	7	0	1	2	2	0	2	0	0.015	0.055
168	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(3), CALM2(1), CAMK1(1), INSR(4), MEF2A(1), NFATC2(1), PIK3CA(8), PIK3R1(2), PPP3CC(1)	16796439	24	24	24	7	3	10	5	2	4	0	0.016	0.057
169	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	GBA3(1), MPO(3), PRDX1(1), PRDX5(1), TPO(1), TYR(2)	4776007	9	9	9	0	0	2	5	1	1	0	0.016	0.060
170	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ADSL(1), AK2(1), AK5(1), ALLC(1), AMPD3(1), ENPP3(2), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), IMPDH1(1), IMPDH2(2), NPR1(3), NPR2(1), NT5C1B(1), NT5C3(1), NUDT9(1), PAPSS2(1), PDE11A(2), PDE1C(1), PDE2A(2), PDE3B(1), PDE4A(2), PDE4C(4), PDE5A(1), PDE8A(1), PFAS(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1), PRIM2(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2(1), XDH(2)	81223845	80	68	78	16	10	22	28	3	17	0	0.017	0.060
171	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), HLA-DRB1(3), IL3(1)	1328354	5	4	5	2	1	1	1	1	1	0	0.017	0.060
172	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(1), NFKBIB(1), NFKBIL2(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), TRAF3(1), TRAF5(1), TRAF6(1)	15783568	22	22	22	10	5	8	5	0	4	0	0.017	0.060
173	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), HRAS(2), PIK3CA(8), PIK3R1(2), RALBP1(1), RELA(1)	9432966	16	16	16	5	3	7	4	0	2	0	0.017	0.060
174	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	AKT1(2), CAMK2G(2), GNAS(1), HRAS(2), PIK3CA(8), PIK3R1(2), PRKACB(1), RPS6KA1(1), SOS1(4)	14167132	23	22	23	9	4	9	9	0	1	0	0.017	0.060
175	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(1), F2(2), FGA(1), PLAT(2), PLAU(3), PLG(1)	6608056	11	11	11	6	1	4	2	0	4	0	0.017	0.060
176	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), DIAPH1(1), FYN(1), HRAS(2), ITGA1(1), ITGB1(2), MYLK(2), PIK3CA(8), PIK3R1(2), PTK2(1), ROCK1(2), TLN1(3)	18634320	26	26	26	10	4	10	9	1	2	0	0.018	0.061
177	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(2), ALOX5(1), GGT1(2), LTA4H(1), PLA2G6(2), PTGDS(1), PTGS2(2)	7375888	11	11	11	2	0	5	3	0	3	0	0.018	0.061
178	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HBXIP(1), HRAS(2), PTK2B(2), SOS1(4)	4312977	9	9	9	0	1	3	4	0	1	0	0.018	0.062
179	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY8(4), CACNA1A(1), GNAS(1), GNB1(2), GNG3(1), GRM4(1), ITPR3(1), PLCB2(1), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1G(1), TAS1R2(3), TAS2R3(1), TAS2R38(1), TAS2R46(2), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(2)	27822259	30	29	30	11	3	10	12	0	5	0	0.019	0.065
180	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1), MASP2(1)	10519915	17	16	17	3	0	4	11	1	1	0	0.019	0.066
181	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(2), BCAR1(2), CSK(1), CTNNA1(2), CTNNA2(4), PTK2(1), VCL(1)	9824853	13	12	13	5	3	4	2	1	3	0	0.020	0.067
182	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(2), EGF(1), EGFR(4), HRAS(2), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K5(1), PPP2CA(2), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), RELA(1), RIPK1(1), TNFRSF1A(1)	24032454	28	26	28	12	5	8	9	0	6	0	0.020	0.069
183	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(2), CD19(1), CD22(2), CR2(2), CSK(1), GSK3A(2), GSK3B(1), ITPR1(1), ITPR2(4), ITPR3(1), MAP4K1(1), NFATC2(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), PPP3CC(1), PTPRC(4), SOS1(4), SOS2(2), SYK(1), VAV1(1)	36106397	48	41	48	10	7	16	16	1	8	0	0.021	0.071
184	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(1), GGT1(2), GPX3(3), GSS(1), IDH1(1), IDH2(1)	8825515	12	12	12	6	1	3	6	0	2	0	0.024	0.079
185	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(1), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(1)	3973275	7	7	6	2	0	2	4	0	1	0	0.024	0.080
186	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BIRC2(2), BIRC3(1), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), HELLS(1), JUN(1), MAP3K1(1), MAPK10(1), NFKBIB(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1), TRAF3(1)	27753187	32	30	32	13	5	7	14	0	6	0	0.025	0.082
187	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(2), JAK2(2), PTPRU(2), STAT1(3)	5666393	10	9	10	1	1	6	1	0	2	0	0.025	0.083
188	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	BRAF(3), FYN(1), HLA-B(1), HLA-C(1), HLA-E(1), HRAS(2), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), ITGAL(2), KLRC1(1), MICB(1), NFAT5(1), NFATC2(1), NFATC3(2), PAK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PPP3CC(1), PRKCG(2), PTK2B(2), PTPN11(1), SH3BP2(1), SOS1(4), SOS2(2), SYK(1), TNFRSF10A(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(1), VAV3(1), ZAP70(1)	55038056	65	54	65	29	7	26	22	0	10	0	0.025	0.083
189	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(2), HRAS(2), KDR(2), NFAT5(1), NFATC2(1), NFATC3(2), NOS3(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLA2G12A(1), PLA2G6(2), PLCG1(1), PLCG2(1), PPP3CC(1), PRKCG(2), PTGS2(2), PTK2(1), SPHK2(1), VEGFA(1)	35009255	42	36	42	20	4	16	15	0	7	0	0.026	0.083
190	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1)	10221977	16	15	16	1	0	3	11	1	1	0	0.027	0.087
191	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(1), ENPP3(2), NNT(4)	7197618	12	12	12	0	2	3	3	2	2	0	0.027	0.087
192	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(1), CBR1(1), CYP4F2(1), GGT1(2), LTA4H(1), MPO(3), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS2(2), TPO(1)	13668371	17	17	17	3	0	6	8	0	3	0	0.027	0.087
193	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(1), AGXT2(1), AKR1B10(2), ALAS2(1), AOC2(1), CHDH(2), DAO(1), DMGDH(1), GATM(2), MAOA(1), MAOB(1), PHGDH(1), RDH13(1), SARDH(1), SARS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(2)	21206867	29	26	29	6	3	9	11	3	3	0	0.028	0.088
194	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT2(1), GALNT5(3), GALNT7(3), GALNTL2(1), GALNTL4(1), GCNT1(2), OGT(3), WBSCR17(1)	15859519	19	19	19	9	3	6	5	0	5	0	0.028	0.088
195	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(4), ABCA10(3), ABCA12(4), ABCA13(5), ABCA2(1), ABCA4(2), ABCA5(3), ABCA6(1), ABCA7(4), ABCA8(2), ABCA9(2), ABCB1(3), ABCB11(2), ABCB4(1), ABCC1(1), ABCC10(1), ABCC11(1), ABCC12(2), ABCC3(3), ABCC4(3), ABCC5(1), ABCC6(1), ABCC8(1), ABCC9(3), ABCD2(1), ABCD3(1), ABCD4(3), ABCG1(1), ABCG4(2), ABCG5(1), CFTR(3), TAP1(1), TAP2(1)	57591290	68	56	68	29	4	25	29	4	6	0	0.029	0.091
196	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(2), B3GALT4(1), FAU(1), IL6ST(2), PIGK(1), RPL15(1), RPL19(1), RPL22(1), RPL27(1), RPL30(1), RPL31(1), RPL34(1), RPL4(1), RPL5(1), RPL7(1), RPLP0(1), RPS13(1), RPS26(1), RPS29(1), RPS3A(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), RPS6KB1(2), SLC36A2(1), TSPAN9(1)	25573777	32	29	32	7	3	10	13	1	5	0	0.030	0.094
197	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), CALM2(1), CHRNA1(1), FLT1(2), FLT4(3), KDR(2), NOS3(1), PDE2A(2), PDE3A(2), PDE3B(1), PRKACB(1), PRKG1(1), PRKG2(1), RYR2(3)	20010945	24	24	24	8	6	6	8	1	3	0	0.030	0.095
198	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	GOT1(2), GOT2(3), PAH(1)	4059837	6	6	6	0	1	1	2	0	2	0	0.031	0.095
199	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCND2(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), RB1(3)	7818193	12	11	12	9	0	6	4	0	2	0	0.032	0.098
200	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(2), ALOX5(1), CBR1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2J2(1), CYP4A11(2), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(3), LTA4H(1), PLA2G12A(1), PLA2G6(2), PTGDS(1), PTGS2(2)	19256833	27	24	27	7	3	6	13	1	4	0	0.033	0.10
201	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4R(1), IRS1(1), JAK1(2), JAK3(1), RPS6KB1(2), STAT6(2)	7150692	11	10	11	2	2	2	3	0	4	0	0.035	0.11
202	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(2), BRAF(3), EGFR(4), EPHB2(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(1), PLCB4(3), SOS1(4), SOS2(2)	29039649	36	33	36	14	2	14	14	1	5	0	0.036	0.11
203	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(1), AGXT2(1), ALAS2(1), AOC2(1), CHDH(2), DAO(1), DMGDH(1), GATM(2), MAOA(1), MAOB(1), PLCB2(1), PLCG1(1), PLCG2(1), SARDH(1), SARS(2), SHMT1(1), SHMT2(2), TARS(1)	20779099	26	25	26	6	1	8	11	3	3	0	0.036	0.11
204	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CSK(1), EPHB2(1), FBXW7(3), ITK(2), ITPKA(1), ITPKB(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(4), RASGRP2(2), RASGRP4(2), SOS1(4), SOS2(2), VAV1(1), ZAP70(1)	27286173	35	32	35	11	4	12	16	0	3	0	0.036	0.11
205	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GLB1(3), GNS(1), GUSB(2), HEXA(1), IDS(2), IDUA(1), LCT(1), NAGLU(1)	7108167	13	11	13	3	1	4	4	1	3	0	0.038	0.11
206	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(2), CASP2(1), CASP8(1), JUN(1), LMNB1(1), MADD(2), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(2), RB1(3), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TRADD(1)	19552017	20	20	19	13	0	6	9	0	5	0	0.038	0.11
207	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(6)	3935694	7	7	7	2	1	1	4	0	1	0	0.039	0.11
208	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	GTF2E2(2), GTF2H1(2), GTF2H2(2), ILK(1), MNAT1(1), POLR1A(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3B(5), POLR3H(1), TAF13(1), TAF5(3)	17252534	25	24	23	11	2	12	8	0	3	0	0.039	0.11
209	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(2), ABCB4(1), ABCC1(1), ABCC3(3)	7150579	10	10	10	0	0	6	2	1	1	0	0.040	0.12
210	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), HARS(1), MAOA(1), MAOB(1), PRPS2(1)	12024157	17	16	17	3	2	2	8	4	1	0	0.041	0.12
211	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADS(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOX1(5), BCAT1(1), ECHS1(1), HADHA(1), HADHB(2), IVD(1), MCCC2(3), MCEE(1), OXCT1(1), PCCA(1), PCCB(1)	17749922	24	24	24	7	6	6	8	1	3	0	0.043	0.12
212	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(1), WEE1(1)	6831521	10	9	10	9	0	2	5	0	3	0	0.043	0.12
213	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), CD38(1), ENPP3(2), NNT(4), NT5C1B(1), NT5C3(1), NUDT12(1)	10657174	15	15	15	3	2	4	5	2	2	0	0.044	0.13
214	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	JUN(1), KEAP1(2), NFE2L2(4)	4243937	7	7	7	5	0	1	4	1	1	0	0.045	0.13
215	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	AKT1(2), CSF2RB(1), IL3(1), KITLG(1), PIK3CA(8), PIK3R1(2), PRKACB(1)	10269441	16	16	16	7	4	8	3	0	1	0	0.049	0.14
216	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CALM2(1), CAMK2G(2), F2(2), FYN(1), GNB1(2), HRAS(2), JAK2(2), MAPT(1), MYLK(2), PLCG1(1), PTK2B(2), SOS1(4), STAT1(3)	20609579	25	25	25	7	1	7	13	2	2	0	0.049	0.14
217	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	HRAS(2), IRS1(1), JUN(1), PIK3CA(8), PIK3R1(2), PTPN11(1), SOS1(4)	11977908	19	18	19	9	4	7	7	0	1	0	0.049	0.14
218	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), HLA-DRA(1), HLA-DRB1(3)	1828206	5	4	5	3	0	2	1	1	1	0	0.050	0.14
219	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA(2), GBA3(1), MPO(3), TPO(1)	4168251	7	7	7	2	0	3	3	1	0	0	0.050	0.14
220	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(5), AXIN1(1), BMP2(1), BMP4(1), BMP7(1), BMPR2(2), CHRD(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(1), NPPB(1), RFC1(1), TGFB2(1), TGFB3(1), TGFBR2(2)	17503505	24	21	24	11	6	5	8	0	5	0	0.057	0.16
221	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASDHPPT(1), AASS(1), KARS(1)	3427954	5	5	5	1	0	2	0	0	3	0	0.058	0.16
222	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(2), CD19(1), CSK(1), EPHB2(1), ITPKA(1), ITPKB(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), SERPINA4(1), SOS1(4), SOS2(2), SYK(1), VAV1(1)	25331626	34	31	34	9	5	14	11	0	4	0	0.059	0.16
223	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	HRAS(2), IL6R(1), IL6ST(2), JAK1(2), JAK2(2), JAK3(1), JUN(1), PTPN11(1), SOS1(4)	11734328	16	15	16	5	3	4	6	0	3	0	0.062	0.17
224	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	CASP10(2), CASP8(1), DAXX(2), DEDD(2), EGFR(4), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MET(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TP53(11)	35829560	41	35	41	17	6	13	15	0	7	0	0.063	0.17
225	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(2), BIRC2(2), BIRC3(1), CASP8(1), JUN(1), MAP3K3(1), MAP3K7(1), NFKBIB(1), NFKBIL2(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1)	12878207	16	16	15	8	2	5	6	0	3	0	0.064	0.17
226	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	748503	2	2	2	1	0	1	1	0	0	0	0.064	0.18
227	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CUL1(2), RB1(3)	4269289	6	6	6	5	0	2	1	0	3	0	0.067	0.18
228	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2E2(2), GTF2H1(2), GTF2H2(2), GTF2I(1), TAF1(2), TAF13(1), TAF1L(2), TAF4B(2), TAF5(3), TAF5L(1), TAF7L(2)	17607334	21	21	21	5	1	7	11	1	1	0	0.068	0.18
229	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV2(1)	3436193	6	6	6	2	1	2	3	0	0	0	0.070	0.19
230	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), CLOCK(1), EIF4G2(2), ETV6(1), HERPUD1(1), HSPA8(4), MYF6(1), NCKAP1(1), NCOA4(2), PER1(2), PER2(1), PSMA4(1), UGP2(1), ZFR(3)	17955631	22	21	22	7	1	7	9	1	4	0	0.070	0.19
231	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(4), MAP3K1(1), NCOR2(3), RARA(2), THRA(1)	8436214	12	12	12	0	1	4	4	0	3	0	0.072	0.19
232	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK1(2), JAK2(2), JAK3(1), STAT1(3), STAT5B(1), TYK2(2)	9052577	12	11	12	6	1	4	4	1	2	0	0.075	0.20
233	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	CALM2(1), HRAS(2), JUN(1), MAP2K7(1), MAP3K1(1), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PLCG1(1), PPP3CC(1), SOS1(4), SYK(1), VAV1(1)	20719458	27	26	27	11	5	10	8	0	4	0	0.079	0.21
234	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGAL(2), ITGB1(2), SELE(3)	6346170	9	9	9	4	1	2	5	0	1	0	0.079	0.21
235	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(2), BIRC3(1), CASP10(2), CASP7(1), CASP8(1), SCAP(1), SREBF2(3)	8808028	11	11	11	3	4	1	4	0	2	0	0.086	0.22
236	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), AR(1), ESRRA(1), NR1H2(2), NR1H3(1), NR1I2(1), NR2C2(1), NR2F2(1), NR5A2(2), PGR(1), RARA(2), RARB(1), RORA(1), RORC(1), RXRB(1), RXRG(2), THRA(1), VDR(1)	20251673	22	21	21	8	3	7	5	2	5	0	0.086	0.23
237	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), GAA(2), GALE(1), GALK1(1), GALK2(1), GLB1(3), HK1(3), LALBA(1), LCT(1), MGAM(2), PFKM(2), RDH13(1), UGP2(1)	18848844	21	20	21	3	1	6	7	2	5	0	0.088	0.23
238	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(1), CREBBP(3), EP300(3), FZD1(2), GSK3B(1), TRRAP(2)	15946260	17	17	17	15	0	3	11	0	3	0	0.089	0.23
239	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), FYN(1), HRAS(2), JUN(1), MAP3K1(1), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PLCG1(1), PPP3CC(1), PTPN7(1), RELA(1), SOS1(4), VAV1(1), ZAP70(1)	23244961	29	28	29	15	4	12	10	0	3	0	0.089	0.23
240	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(1), THBS1(4)	3591166	6	6	6	2	0	1	4	1	0	0	0.090	0.23
241	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(1), EGF(1), EGFR(4), MET(1), PDGFRA(3)	9609009	11	11	11	8	2	3	3	0	3	0	0.091	0.23
242	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG1(1), CPS1(5), GATM(2), SMS(1)	8493042	11	11	11	5	0	4	5	0	2	0	0.097	0.25
243	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH13(1)	2364724	4	4	4	0	1	0	2	0	1	0	0.097	0.25
244	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD4(1), ITGAL(2), PTPRC(4)	5512508	7	7	7	3	1	2	3	0	1	0	0.099	0.25
245	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GABBR1(1), GPRC5A(1), GPRC5C(1), GRM1(1), GRM2(2), GRM3(1), GRM4(1), GRM5(1), GRM7(1), GRM8(1)	9761324	12	12	12	2	3	3	5	0	1	0	0.10	0.26
246	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1)	11422889	16	15	14	2	1	8	4	0	3	0	0.10	0.26
247	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1)	6443467	7	6	7	2	0	1	3	0	3	0	0.10	0.26
248	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(1), KARS(1)	2333393	3	3	3	1	0	1	0	0	2	0	0.11	0.26
249	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	HRAS(2), IL2RB(1), JAK1(2), JAK3(1), JUN(1), SOS1(4), STAT5B(1), SYK(1)	11540060	13	13	13	3	2	3	5	0	3	0	0.11	0.26
250	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(5), AXIN1(1), CREBBP(3), FZD1(2), GSK3B(1), MAP3K7(1), PPP2CA(2)	14204951	15	15	15	12	0	3	8	0	4	0	0.11	0.26
251	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(1), GALNT7(3), GCNT1(2), WBSCR17(1)	7055661	8	8	8	3	1	2	2	0	3	0	0.11	0.26
252	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(3), DLL1(1), DLL4(1), DTX3(2), DTX3L(1), DTX4(1), EP300(3), JAG1(1), MAML1(2), MAML2(1), MAML3(1), NCOR2(3), NCSTN(1), NOTCH1(6), NOTCH2(2), NOTCH3(2), NUMB(2), PSEN2(1), RBPJL(1)	32576394	35	31	35	17	4	6	16	1	6	2	0.11	0.26
253	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(3), CLYBL(1), CS(1), IDH1(1), IDH2(1), MDH1(1), OGDH(2), OGDHL(1), PCK1(2), SDHA(1), SDHD(1), SUCLG1(2), SUCLG2(1)	14727273	21	18	21	9	1	9	8	0	3	0	0.11	0.26
254	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BAG4(2), BIRC2(2), BIRC3(1), CASP2(1), CASP7(1), CASP8(1), DAXX(2), LMNB1(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), PRKCD(2), PRKDC(2), PSEN2(1), PTK2(1), RB1(3), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TRADD(1)	34282887	28	27	27	17	4	8	11	0	5	0	0.11	0.27
255	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CPS1(5), EPRS(1), GAD1(1), GFPT1(1), GLS(1), GLS2(1), GOT1(2), GOT2(3), GPT2(1), GSS(1)	16220031	18	17	18	6	2	8	5	0	3	0	0.11	0.27
256	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(1), CAPN3(1), CAPN7(1), CAPN9(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGAE(2), ITGAL(2), ITGAX(1), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), MAP2K3(2), MAPK10(1), MAPK4(1), PAK1(1), PAK4(2), PAK6(1), PTK2(1), ROCK1(2), SDCCAG8(1), SORBS1(1), SOS1(4), TLN1(3), TNS1(3), VAV3(1), VCL(1)	66784386	61	56	61	18	4	18	32	0	7	0	0.11	0.27
257	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F12(1), F2(2), F5(3), F8(1), FGA(1), PLAT(2), PLAU(3), PLG(1), SERPINF2(1), VWF(5)	17065317	20	19	20	11	0	8	8	0	4	0	0.11	0.27
258	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(3), GLI3(2), GSK3B(1), PRKACB(1), SMO(2)	7807771	10	10	10	3	0	3	6	1	0	0	0.11	0.27
259	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(1), EGFR(4), HRAS(2), PTPRB(2), SOS1(4), SPRY2(1)	12052154	15	15	15	5	2	6	4	1	2	0	0.12	0.28
260	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(3), ACSS1(2), ACSS2(2), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), PCCA(1), PCCB(1), SUCLG1(2), SUCLG2(1)	19481375	22	22	22	10	2	7	7	1	5	0	0.12	0.28
261	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(3), EP300(3), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1)	10891870	11	11	11	6	0	1	7	0	3	0	0.12	0.28
262	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), GRIN1(1), GRIN2A(3), GRIN2B(4), NOS1(5), PPP3CC(1), PRKACB(1)	12465844	16	16	16	7	1	5	9	0	1	0	0.12	0.28
263	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(2), JAK2(2), TYK2(2)	5132519	7	6	7	3	0	2	2	1	2	0	0.12	0.28
264	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(2), JAK2(2), TYK2(2)	5132519	7	6	7	3	0	2	2	1	2	0	0.12	0.28
265	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), CREB5(1), EPHB2(1), ITPKA(1), ITPKB(1), JUN(1), MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1)	13528521	15	15	15	13	1	5	6	0	3	0	0.13	0.29
266	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1)	3887372	6	6	6	2	2	1	2	1	0	0	0.13	0.29
267	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), CS(1), IDH1(1), IDH2(1), MDH1(1), PCK1(2), SDHA(1), SUCLG1(2), SUCLG2(1)	10188980	13	13	13	7	0	6	4	0	3	0	0.13	0.30
268	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), LUM(1)	1784260	3	3	3	0	0	1	1	0	1	0	0.13	0.30
269	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA2(1), GLB1(3), HEXA(1), LCT(1), MAN2C1(4)	7953557	10	9	10	3	0	4	4	1	1	0	0.13	0.30
270	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(1), HLA-DRA(1), HLA-DRB1(3)	2492016	5	4	5	4	0	2	1	1	1	0	0.13	0.30
271	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(1), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), BBOX1(1), DOT1L(2), ECHS1(1), EHMT2(2), HADH(1), HADHA(1), HSD17B4(1), NSD1(2), OGDH(2), OGDHL(1), PLOD2(1), PLOD3(1), RDH13(1), SETD1A(1), SETDB1(1), SHMT1(1), SHMT2(2)	28031433	29	29	29	6	2	7	14	1	5	0	0.13	0.30
272	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(5), EPHB2(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), RYR1(3)	22957004	21	21	21	16	0	7	9	1	4	0	0.13	0.30
273	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG10(1), ALG10B(1), ALG13(1), ALG3(1), ALG8(1), B3GNT6(1), B3GNT7(1), B4GALT4(2), C1GALT1C1(1), CHST1(1), DPAGT1(1), EXT1(1), EXTL3(1), FUT11(1), GALNT1(1), GALNT11(1), GALNT2(1), GALNT5(3), GALNT7(3), GALNTL2(1), GALNTL4(1), GCNT1(2), HS6ST3(1), MAN1A2(1), MAN2A1(1), MGAT3(1), MGAT4A(1), MGAT5(1), NDST4(1), OGT(3), RPN1(2), RPN2(1), ST3GAL3(1), STT3B(1), WBSCR17(1), XYLT1(1), XYLT2(1)	53571744	47	43	47	19	4	14	17	1	11	0	0.13	0.30
274	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(1), CES1(3), CES7(1), MYST3(4), PNPLA3(1)	12415482	15	14	15	4	1	4	7	3	0	0	0.14	0.30
275	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	GPI(1), HK1(3), PGAM1(1), PGK1(3)	4267803	8	6	8	2	0	2	5	1	0	0	0.14	0.30
276	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), HARS(1), HARS2(1), LCMT2(1), MAOA(1), MAOB(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS2(1), UROC1(1)	19387189	24	20	24	4	2	3	13	4	2	0	0.14	0.30
277	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(1), GGT1(2)	2829117	3	3	3	1	0	0	2	0	1	0	0.14	0.31
278	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CHIT1(1), CTBS(1), CYB5R1(2), GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), MTMR1(2), MTMR2(1), NANS(1), RENBP(2)	14081415	18	17	18	2	1	5	10	1	1	0	0.14	0.32
279	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), ASCC3(2), ATP13A2(4), DDX18(2), DDX50(2), DDX56(1), DHX58(1), EP400(1), FPGS(2), IFIH1(2), RAD54L(1), SKIV2L2(1), SMARCA2(4), SMARCA5(2)	30961716	31	28	31	12	0	9	16	1	5	0	0.14	0.32
280	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(2), PTPRC(4)	5218168	6	6	6	2	1	1	3	0	1	0	0.14	0.32
281	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	CASP1(1), CASP7(1), CASP8(1), INSR(4), MAGI1(2), MAGI2(1), RERE(2), WWP2(1)	11513864	13	13	13	4	1	5	4	1	2	0	0.14	0.32
282	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), LTB4R(1), P2RY2(1)	2696735	3	3	3	2	0	0	2	0	1	0	0.14	0.32
283	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(2), ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GAPDHS(2), GPI(1), HK1(3), LDHAL6B(1), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3)	28165196	31	28	31	7	3	4	13	4	7	0	0.15	0.32
284	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(1), TH(1)	2859292	4	4	4	1	0	0	3	1	0	0	0.15	0.32
285	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA4(1), PSMA6(1), RPN1(2), RPN2(1), UBE2A(1)	6432172	7	7	7	3	1	0	3	2	1	0	0.15	0.33
286	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR2(1), DNMT1(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1)	5361002	7	7	7	1	0	3	3	0	1	0	0.15	0.33
287	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(2), SELE(3)	5605345	7	7	7	4	0	2	4	0	1	0	0.15	0.33
288	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(1), HRAS(2), IL3(1), JAK2(2), SOS1(4), STAT5B(1)	8336733	11	11	11	1	2	4	5	0	0	0	0.16	0.34
289	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSL(1), AGXT(1), AGXT2(1), ASNS(1), DARS(1), GAD1(1), GOT1(2), GOT2(3), GPT2(1)	12801712	12	12	12	4	1	3	4	0	4	0	0.16	0.34
290	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CALM2(1), HRAS(2), JUN(1), MAP2K3(2), MAP3K1(1), PAK1(1), PLCG1(1), PTK2B(2), SOS1(4)	13925154	17	16	17	7	2	3	9	0	3	0	0.16	0.34
291	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), CALM2(1), CAMK2G(2), CREBBP(3), DCT(1), EP300(3), FZD1(2), FZD10(1), FZD4(1), FZD5(1), GNAO1(1), GNAS(1), GSK3B(1), HRAS(2), KITLG(1), MITF(1), PLCB1(1), PLCB2(1), PLCB4(3), POMC(1), PRKACA(1), PRKACB(1), PRKCG(2), TCF7(2), TYR(2), TYRP1(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1)	52988976	52	48	51	33	1	17	28	0	6	0	0.16	0.34
292	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(1), THTPA(1), TPK1(1)	3141313	5	5	5	1	0	3	2	0	0	0	0.16	0.34
293	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	AKT1(2), FLNA(2), FLNC(3), FSCN1(2), MYH2(5), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), ROCK1(2), WASL(2)	23076020	25	23	25	5	1	8	12	1	3	0	0.16	0.34
294	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(3), EP300(3), NCOA3(3), PRKACB(1), RARA(2)	10035320	12	12	12	4	0	4	7	0	1	0	0.16	0.34
295	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGAL(2), ITGB1(2), SELE(3), SELP(1)	8328406	10	10	10	5	1	2	6	0	1	0	0.16	0.34
296	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ECHS1(1), HADHA(1)	2649293	4	4	4	3	0	1	3	0	0	0	0.16	0.34
297	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), HLA-DRA(1), HLA-DRB1(3), IFNB1(1), IL3(1), TGFB2(1), TGFB3(1)	6360873	9	8	9	5	2	3	2	1	1	0	0.17	0.34
298	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ABP1(4), ALDH1B1(2), ALDH3A2(1), AOC2(1), AOX1(5), CAT(2), CYP1A1(1), DDC(2), ECHS1(1), HADH(1), HADHA(1), HSD17B4(1), LCMT2(1), MAOA(1), MAOB(1), OGDH(2), OGDHL(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TPH2(2)	29445365	35	30	35	8	4	9	15	5	2	0	0.17	0.35
299	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), IDH2(1), MDH1(1), OGDH(2), SDHA(1)	4644957	6	6	6	1	0	2	3	0	1	0	0.17	0.35
300	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(1), CARS(2), CARS2(1), DARS(1), EPRS(1), HARS(1), HARS2(1), IARS(1), IARS2(2), KARS(1), MARS(1), NARS2(1), PARS2(1), SARS(2), TARS(1), TARS2(2), VARS2(4), YARS2(1)	25902714	25	25	25	8	4	6	10	0	5	0	0.17	0.35
301	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GAA(2), GALE(1), GALK1(1), GALK2(1), GLB1(3), HK1(3), LALBA(1), LCT(1), MGAM(2), PFKM(2)	15995501	17	16	17	3	0	5	6	2	4	0	0.17	0.35
302	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), IDH1(1), IDH2(1), MDH1(1)	4389294	6	6	6	3	0	2	3	0	1	0	0.17	0.35
303	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK2G(2), CAMKK1(1), CAMKK2(2)	5731873	7	7	7	1	0	1	4	1	1	0	0.18	0.36
304	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACADS(2), ALDH1B1(2), ALDH3A2(1), AOX1(5), BCAT1(1), ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), IVD(1), MCCC2(3), MCEE(1), OXCT1(1), PCCA(1), PCCB(1)	21299672	25	24	25	7	5	8	8	1	3	0	0.18	0.36
305	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(1)	3496315	5	5	5	0	0	2	2	0	1	0	0.18	0.36
306	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(1), HRAS(2), KLK2(1)	3984279	5	5	5	1	0	3	1	1	0	0	0.18	0.36
307	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD4(1), IL12RB1(1), IL12RB2(1), JAK2(2), STAT4(2), TYK2(2)	7207181	9	9	9	4	1	4	2	1	1	0	0.18	0.36
308	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	354468	1	1	1	0	0	1	0	0	0	0	0.18	0.36
309	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	CREM(1), FHL5(2), GNAS(1), XPO1(2)	4562040	6	6	6	1	0	3	2	1	0	0	0.18	0.36
310	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2A1(2), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), DAXX(2), PTPN13(1), RIPK1(1), SFRS2IP(1), TFG(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1)	21618286	19	19	19	3	3	2	10	0	4	0	0.19	0.37
311	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), ARF1(1), EEA1(1), GSK3A(2), GSK3B(1), PFKM(2), PLCG1(1), PRKCZ(1), RAB5A(1), RPS6KB1(2)	12465674	14	14	14	3	2	4	5	0	3	0	0.19	0.37
312	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASDHPPT(1), AASS(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), BBOX1(1), DOT1L(2), ECHS1(1), EHMT2(2), HADHA(1), PLOD2(1), PLOD3(1), SHMT1(1), SHMT2(2)	17622460	20	19	20	2	1	5	9	1	4	0	0.19	0.37
313	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP7(1), CASP8(1), DAXX(2), JUN(1), LMNB1(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(2), PTPN13(1), RB1(3), RIPK2(1), SPTAN1(1)	21115404	19	19	19	12	3	3	8	0	5	0	0.19	0.37
314	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CREB5(1), DUSP10(1), EIF4E(1), MAP2K3(2), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(1), MAPKAPK5(1), MKNK2(2), NR2C2(1), TRAF6(1)	16402798	18	16	18	4	3	4	8	0	3	0	0.19	0.37
315	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(1), TYK2(2)	5821323	7	6	7	5	1	1	2	1	2	0	0.19	0.38
316	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), HLA-DRB1(3), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL4R(1)	6138997	9	8	9	3	1	4	2	1	1	0	0.19	0.38
317	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA2(1), GLB1(3), HEXA(1), LCT(1), MAN2B2(2), MAN2C1(4)	9810644	12	10	12	3	0	5	5	1	1	0	0.19	0.38
318	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB1A(1), RAB5A(1), RAB9A(1)	2127794	4	4	4	1	2	0	2	0	0	0	0.20	0.38
319	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1)	4127532	7	6	7	1	2	3	2	0	0	0	0.20	0.38
320	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(2), CYP11A1(1), HPGD(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGFR(1), PTGS2(2)	10086362	12	12	12	4	0	6	3	0	3	0	0.20	0.38
321	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	DBH(2), DDC(2), GAD1(1), MAOA(1), PAH(1), TH(1)	7000508	8	8	8	4	1	1	4	2	0	0	0.20	0.38
322	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), JAK1(2), STAT1(3)	5907858	6	6	6	4	0	4	0	0	2	0	0.20	0.38
323	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), HADH(1), HADHA(1), HSD17B4(1), SIRT1(1), SIRT5(1)	5762755	6	6	6	0	0	4	1	0	1	0	0.20	0.39
324	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(4), ALDH1B1(2), ALDH3A2(1), AOC2(1), DPYS(1), ECHS1(1), GAD1(1), HADHA(1), MLYCD(1), SMS(1)	13188242	14	14	14	6	0	1	9	3	1	0	0.20	0.39
325	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(1), POLR2A(4), PRKACB(1)	6231588	7	6	7	0	0	2	4	0	1	0	0.21	0.39
326	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN2(2), BCAR1(2), CAPN1(1), CSK(1), FYN(1), HRAS(2), ITGA1(1), ITGB1(2), JUN(1), PPP1R12B(1), PTK2(1), ROCK1(2), SOS1(4), TLN1(3), VCL(1)	23124901	26	23	26	9	4	8	11	0	3	0	0.21	0.40
327	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(1), CPO(1), FECH(1), HBB(2)	4040289	5	5	5	2	2	1	0	0	2	0	0.22	0.41
328	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), GNB1(2), PPP2CA(2), PRKACB(1), PRKAG1(2), PRKAG2(1)	7378253	9	9	9	1	1	3	4	0	1	0	0.22	0.41
329	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), CS(1), MDH1(1), MTHFD1(2), MTHFD1L(1)	6313760	8	8	8	2	1	2	5	0	0	0	0.22	0.42
330	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), B4GALT6(1), ENPP7(3), GAL3ST1(1), GBA(2), GLB1(3), LCT(1), PPAP2C(1), SGPP2(1), SMPD1(1), SPHK2(1), UGT8(2)	16946269	19	18	18	11	1	9	5	1	3	0	0.22	0.42
331	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PTK2B(2)	3302272	4	4	4	2	0	1	2	0	1	0	0.22	0.42
332	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CDK2(1), CDK4(1), CDKN2A(1)	4271198	5	5	5	3	0	2	2	0	1	0	0.23	0.42
333	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ENPP3(2), FLAD1(1), MTMR1(2), MTMR2(1), TYR(2)	7398735	9	9	9	0	1	1	5	1	1	0	0.23	0.42
334	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), NCOA1(1), NCOA2(1), NCOA3(3), NCOR2(3), POLR2A(4), RARA(2)	12323664	15	12	15	8	1	4	9	0	1	0	0.23	0.42
335	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), DPYS(1), ECHS1(1), GAD1(1), HADHA(1), MLYCD(1), SMS(1)	14198337	15	15	15	7	1	1	9	3	1	0	0.23	0.42
336	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), AOX1(5), CAT(2), CYP19A1(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), CYP2J2(1), CYP4B1(1), DDC(2), ECHS1(1), HADHA(1), MAOA(1), MAOB(1)	26774162	31	27	31	8	5	4	14	7	1	0	0.23	0.42
337	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(3), ACVR2A(1), AMHR2(2), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(2), CCL2(1), CSF1R(1), CSF2RB(1), CSF3R(1), CXCL11(1), EDA(1), EGF(1), EGFR(4), FLT1(2), FLT3(1), FLT4(3), GH2(1), GHR(1), HGF(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL17RB(1), IL19(1), IL1R2(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL25(1), IL2RB(1), IL3(1), IL4R(1), IL6R(1), IL6ST(2), INHBE(1), KDR(2), KITLG(1), LEPR(1), LIFR(1), MET(1), PDGFRA(3), PF4(1), PLEKHO2(1), PRLR(1), TGFB2(1), TGFB3(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11B(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF9(1), TPO(1), VEGFA(1), XCL1(1)	85021508	83	73	83	32	15	28	30	2	8	0	0.23	0.42
338	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), EGF(1), EGFR(4), HRAS(2), ITGA1(1), ITGB1(2), MYLK(2), PRKACB(1), PTK2(1), TLN1(3)	16353942	19	18	19	5	3	4	9	1	2	0	0.23	0.42
339	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1B(1), BMPR2(2)	3044412	4	4	4	0	1	1	0	0	2	0	0.24	0.43
340	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ENPP3(2), FLAD1(1), TYR(2)	4791318	6	6	6	0	1	0	3	1	1	0	0.24	0.44
341	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), FBP1(1), G6PD(1), GPI(1), PFKM(2), PRPS1L1(1), PRPS2(1), TALDO1(3)	9949466	11	11	11	6	1	2	6	1	1	0	0.24	0.44
342	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	GGT1(2), LCMT2(1), MARS(1), PAPSS2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SEPHS2(1)	12156958	11	11	11	4	1	3	4	1	2	0	0.25	0.44
343	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), MDH1(1), ME1(1)	4534099	6	6	6	3	0	1	5	0	0	0	0.25	0.44
344	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADRB2(1), CFTR(3), GNAS(1), PRKACB(1)	6212768	6	6	6	3	0	2	3	0	1	0	0.25	0.44
345	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PIK3CB(1), PLD1(1), PLD2(1), PLD3(1)	21894326	20	20	20	4	1	7	8	1	3	0	0.25	0.44
346	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), FBP1(1), G6PD(1), GPI(1), PFKM(2), PRPS1L1(1), PRPS2(1), TALDO1(3), TKTL2(2)	11846628	13	13	13	7	2	2	7	1	1	0	0.25	0.44
347	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(3), NRG2(1), NRG3(2)	4419237	6	6	6	5	0	2	2	1	1	0	0.25	0.44
348	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	CALM2(1), EGFR(4), HRAS(2), JUN(1), MAP3K1(1), MEF2A(1), PAK1(1), PTK2(1), PTK2B(2), SOS1(4)	16739717	18	18	18	8	2	5	8	0	3	0	0.25	0.44
349	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(2), JAK3(1), PIAS1(2), PTPRU(2)	6880358	9	7	9	2	2	3	2	0	2	0	0.25	0.44
350	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(3), EP300(3), GTF2A1(1), HDAC4(1), NCOR2(3), NRIP1(4), POLR2A(4)	23237069	20	18	20	16	0	5	12	0	3	0	0.25	0.44
351	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(1), CASP1(1), CASP10(2), CASP8(1), JUN(1)	6305637	6	6	6	0	1	0	3	0	2	0	0.25	0.44
352	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	NAT1(1), NAT2(2), XDH(2)	3923609	5	5	5	2	2	0	3	0	0	0	0.26	0.45
353	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), MST1(2), MST1R(1)	2938899	4	4	4	0	0	1	3	0	0	0	0.26	0.45
354	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(3), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), PCCA(1), PCCB(1), SUCLG1(2), SUCLG2(1)	16259033	18	18	18	8	2	7	5	1	3	0	0.26	0.45
355	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), CS(1), MDH1(1), MTHFD1(2), MTHFD1L(1)	6623274	8	8	8	2	1	2	5	0	0	0	0.26	0.45
356	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1)	5923064	7	7	7	1	2	1	3	1	0	0	0.27	0.46
357	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1), GNB1(2), PRKACA(1)	3105255	4	4	4	1	0	2	2	0	0	0	0.27	0.46
358	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(3), PIK3R4(3), ULK3(2)	10173933	13	12	13	3	2	7	3	0	1	0	0.27	0.46
359	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), SLC23A1(1), SLC23A2(1), SLC2A3(2)	12745592	14	14	14	6	1	6	5	2	0	0	0.27	0.46
360	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST6GALNAC2(2), ST8SIA1(1)	2764393	4	4	4	1	1	2	1	0	0	0	0.27	0.46
361	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNA13(1), GNB1(2), MYLK(2), PLCB1(1), PPP1R12B(1), ROCK1(2)	10219794	10	10	10	2	1	3	3	1	2	0	0.27	0.47
362	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF5(2), GSK3B(1)	5656518	7	7	7	2	1	3	2	0	1	0	0.28	0.47
363	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM2(1), DCC(2), DPYSL2(1), EFNB2(1), EPHA1(1), EPHA4(1), EPHA5(1), EPHA8(2), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(4), FES(2), FYN(1), GSK3B(1), HRAS(2), ITGB1(2), L1CAM(1), LIMK2(1), MET(1), NFAT5(1), NFATC2(1), NFATC3(2), NGEF(1), NTN4(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PLXNA2(2), PLXNA3(1), PLXNB1(3), PLXNC1(2), PPP3CC(1), PTK2(1), RGS3(3), RND1(1), ROBO1(2), ROBO2(2), ROBO3(1), ROCK1(2), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(1), SEMA4A(1), SEMA4D(1), SEMA4F(1), SEMA4G(1), SEMA6C(1), SEMA6D(1), SLIT1(3), SLIT2(1), SLIT3(3), SRGAP1(1), SRGAP2(1), UNC5A(1), UNC5B(1), UNC5C(1), UNC5D(2)	95824475	89	75	89	41	5	35	37	3	9	0	0.28	0.47
364	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(1), FYN(1), ITGA1(1), ITGB1(2), L1CAM(1), SELP(1)	7734869	9	9	9	5	2	0	7	0	0	0	0.28	0.47
365	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	JUN(1), MAP3K1(1), MAP3K5(1), MAP4K5(3), RELA(1), TNFRSF9(1), TNFSF9(1)	9737473	9	9	9	2	1	2	4	0	2	0	0.29	0.48
366	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(3)	3283960	3	3	3	7	0	2	0	0	1	0	0.29	0.48
367	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLAT(2), IDH2(1), MDH1(1), OGDH(2), PDHX(1), PDK1(1), PDK3(1), PDP2(1), SDHA(1), SDHD(1), SUCLG1(2), SUCLG2(1)	14060874	16	15	16	6	0	8	4	2	2	0	0.29	0.49
368	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	EGF(1), EGFR(4), HRAS(2), JUN(1), PLCG1(1), RELA(1)	10055215	10	10	10	5	1	3	5	0	1	0	0.29	0.49
369	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL3(1), KITLG(1), TGFB2(1), TGFB3(1)	4157404	5	5	5	1	2	2	1	0	0	0	0.29	0.49
370	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP3K1(1), NSMAF(2), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1)	10095378	9	9	9	5	0	1	5	0	3	0	0.30	0.49
371	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC2(1), ARPC3(1), WASL(2)	4028140	5	5	5	2	1	1	3	0	0	0	0.30	0.49
372	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CPS1(5), EPRS(1), GAD1(1), GFPT1(1), GLS(1), GLS2(1), GOT1(2), GOT2(3), GPT2(1), GSS(1)	19339213	18	17	18	7	2	8	5	0	3	0	0.30	0.50
373	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA5B(1), CA9(1), CPS1(5), GLS(1), GLS2(1)	9233145	10	10	10	1	0	6	4	0	0	0	0.30	0.50
374	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(1), ADSL(1), AGXT(1), AGXT2(1), ASNS(1), ASS1(1), DARS(1), DLAT(2), GAD1(1), GOT1(2), GOT2(3), GPT2(1), NARS2(1)	18623928	17	15	17	6	2	3	5	1	6	0	0.30	0.50
375	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(2), BIRC3(1), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), LMNB1(1)	9445671	11	11	11	4	3	3	4	0	1	0	0.31	0.50
376	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	886309	1	1	1	0	0	0	1	0	0	0	0.31	0.50
377	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), UGP2(1), UXS1(1)	2499944	3	3	3	1	0	2	0	1	0	0	0.31	0.50
378	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), ATP7B(2), COX6A2(1), COX7A2(1), NDUFA10(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV2(1), PPA2(2), SDHA(1), SHMT1(1)	18211634	21	20	21	8	7	5	7	0	2	0	0.31	0.50
379	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(1)	2682479	3	3	3	1	0	2	0	0	1	0	0.31	0.50
380	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TGFB2(1), TGFB3(1), TGFBR2(2), TOB2(2)	5263043	6	6	6	2	3	2	0	1	0	0	0.31	0.50
381	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	HRAS(2), JAK2(2), JUN(1), PLCG1(1), SOS1(4), STAT5B(1)	10648180	11	11	11	2	1	3	7	0	0	0	0.31	0.51
382	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(3), FGA(1), PROC(2), TFPI(1)	7922110	9	9	9	3	0	5	3	0	1	0	0.31	0.51
383	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), GRIN1(1), HIF1A(1), JAK2(2), RELA(1)	6289138	7	7	7	0	1	2	4	0	0	0	0.31	0.51
384	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), ASCC3(2), ATP13A2(4), DDX18(2), DDX50(2), DDX56(1), DHX58(1), ENPP3(2), EP400(1), GAA(2), GBA(2), GBA3(1), GPI(1), GUSB(2), GYS1(2), GYS2(1), HK1(3), IFIH1(2), MGAM(2), RAD54L(1), SI(3), SKIV2L2(1), SMARCA2(4), SMARCA5(2), UGP2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1), UXS1(1)	60334316	57	47	57	23	4	16	23	5	9	0	0.32	0.51
385	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(4), HMGCR(1), LIPC(1), LRP1(5), SCARB1(2)	12763083	13	13	13	5	2	6	2	2	1	0	0.32	0.51
386	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), GSK3B(1), MAPT(1), PPP2CA(2)	4631579	5	5	5	0	0	1	1	1	2	0	0.32	0.52
387	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B2(1), CYP19A1(1), HSD17B1(1), HSD17B2(1), HSD17B8(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1)	23525307	24	24	24	8	2	6	12	2	2	0	0.33	0.52
388	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(3), CREB5(1), SNX13(3)	5738631	7	6	7	6	0	3	3	0	1	0	0.33	0.52
389	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(1), SCAP(1), SREBF2(3)	5716128	5	5	5	2	1	1	2	0	1	0	0.33	0.52
390	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ARSE(1), GAL3ST1(1), GBA(2), GLB1(3), LCT(1), PPAP2C(1), SMPD1(1)	11522198	12	11	12	9	0	5	4	1	2	0	0.33	0.53
391	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDK2(1), DIAPH2(1), MCM2(3), MCM6(2), MCM7(1), NACA(2), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), RFC1(1), RFC2(1), RPA3(1), RPA4(1)	24938612	24	24	24	12	5	4	8	0	7	0	0.34	0.53
392	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), DPAGT1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RPN1(2), RPN2(1)	9452406	8	8	8	4	0	1	4	1	2	0	0.34	0.54
393	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK1(2), JAK2(2), JAK3(1), PTPRU(2)	7589078	8	7	8	4	2	2	1	0	3	0	0.35	0.55
394	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), CYP19A1(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), CYP2J2(1), CYP4B1(1)	14358228	16	14	16	6	2	1	10	2	1	0	0.35	0.55
395	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	6913934	7	7	7	2	1	1	3	0	2	0	0.35	0.55
396	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), ANGPTL4(1), APOA5(1), AQP7(1), CYP4A11(2), CYP4A22(1), CYP8B1(2), DBI(1), FADS2(1), GK(1), ILK(1), ME1(1), NR1H3(1), PCK1(2), PLTP(1), RXRB(1), RXRG(2), SCP2(2), SLC27A1(2), SLC27A6(1), SORBS1(1), UCP1(1)	31653372	32	29	32	12	5	12	11	0	4	0	0.35	0.55
397	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), CREB5(1), EIF4E(1), MKNK2(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), SOS1(4), SOS2(2), TRAF3(1)	14641693	17	15	17	7	3	4	8	0	2	0	0.36	0.55
398	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), PPP2CA(2), PRKACB(1), PRKAG1(2)	8972421	9	9	9	3	0	3	4	0	2	0	0.36	0.55
399	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), CEL(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), GK(1), GLB1(3), LCT(1), LIPC(1), LIPF(1), PNLIP(2), PNLIPRP2(1), PPAP2C(1)	23466314	22	20	22	7	3	2	11	2	4	0	0.36	0.56
400	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD4(1), IL3(1), KITLG(1)	3117195	4	4	4	2	1	3	0	0	0	0	0.36	0.56
401	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC4(1)	3607442	3	3	3	3	1	1	0	0	1	0	0.36	0.56
402	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOA(1), FBP1(1), FPGT(1), HK1(3), KHK(2), MPI(1), MTMR1(2), MTMR2(1), PFKM(2), PGM2(1), RDH13(1)	18400760	18	17	18	6	1	5	8	2	2	0	0.37	0.56
403	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BIRC2(2), BIRC3(1), CASP10(2), CASP7(1), CASP8(1), GAS2(1), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFSF10(1), TRADD(1)	16548992	14	14	14	3	4	1	6	0	3	0	0.37	0.56
404	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), JUN(1), MAP2K3(2), MAP3K1(1), MAP4K2(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1)	11885639	11	10	11	4	2	1	6	0	2	0	0.37	0.56
405	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	IL12RB1(1), IL12RB2(1), JAK2(2), JUN(1), STAT4(2), TYK2(2)	9126453	9	9	9	4	1	3	3	1	1	0	0.37	0.56
406	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NOX1(1), RELA(1), XDH(2)	4846850	5	5	5	1	0	1	4	0	0	0	0.37	0.57
407	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), JUN(1), PLCG1(1), PTK2B(2)	6583910	6	6	6	4	0	1	4	0	1	0	0.38	0.58
408	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLD1(2), POLD3(1), POLE(1), POLE2(1), POLG2(3), POLH(2), POLI(2), POLL(1), POLM(1), POLQ(3), PRIM2(1), REV3L(4)	20602122	22	20	22	5	4	4	8	1	5	0	0.38	0.58
409	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1)	7021984	7	7	7	1	1	2	3	0	1	0	0.39	0.58
410	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), EIF4E(1), IFRD1(1), NR4A3(1), WDR1(1)	5400923	6	6	6	1	1	1	3	0	1	0	0.39	0.59
411	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(1), EGFR(4), RAB5A(1)	6276884	7	7	7	0	2	3	1	0	1	0	0.39	0.59
412	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(3), GZMA(1), HMGB2(1)	5262970	5	5	5	2	0	0	3	1	1	0	0.40	0.60
413	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(2), DHRS2(1), RDH13(1)	4130052	4	4	4	0	1	1	1	0	1	0	0.40	0.60
414	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT4(2), CHST1(1), ST3GAL3(1)	5736792	5	5	5	2	0	1	1	0	3	0	0.41	0.60
415	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(1), ENPP3(2), GAA(2), GBA3(1), GPI(1), GUSB(2), GYS1(2), GYS2(1), HK1(3), MGAM(2), SI(3), UCHL3(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1), UXS1(1)	27566105	27	25	27	11	4	5	8	5	5	0	0.41	0.60
416	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), GREB1(2), HSPB2(1), MTA3(1)	5154148	5	5	5	1	1	0	3	1	0	0	0.41	0.60
417	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	CCKBR(1), CELSR1(3), CELSR3(1), CHRM2(1), EMR3(4), GPR116(1), GPR133(3), GPR17(1), GPR84(2), GRM1(1), HRH4(1), LGR6(2), LPHN3(3), NTSR1(1), OR8G2(1), P2RY13(1), PTGFR(1), SMO(2), TSHR(1)	31849963	31	28	31	8	2	9	16	1	3	0	0.41	0.61
418	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(3), ACSS1(2), ACSS2(2), ALDH1B1(2), ALDH3A2(1), DLAT(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(1), ME3(1), PCK1(2)	22788407	22	20	22	8	3	3	7	3	6	0	0.42	0.61
419	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), UXS1(1)	1987535	2	2	2	1	0	1	0	1	0	0	0.42	0.61
420	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GPI(1), HK1(3), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3)	23773969	24	21	24	6	2	4	10	3	5	0	0.42	0.61
421	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GPI(1), HK1(3), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3)	23773969	24	21	24	6	2	4	10	3	5	0	0.42	0.61
422	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH3A2(1), MIOX(1)	4166374	4	4	4	0	0	0	3	0	1	0	0.42	0.62
423	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT6(1), ST3GAL3(1)	2302256	2	2	2	1	0	0	1	0	1	0	0.42	0.62
424	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	986886	1	1	1	0	0	0	0	1	0	0	0.43	0.62
425	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(5)	4065861	5	5	5	0	0	3	1	1	0	0	0.43	0.62
426	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), PER1(2)	4198038	4	4	4	2	0	2	1	0	1	0	0.43	0.62
427	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	JUNB(2), MAP2K3(2), NFATC2(1), PRKACB(1)	5522879	6	5	6	3	1	0	4	0	1	0	0.43	0.62
428	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA5B(1), CA9(1), CPS1(5), GLS(1), GLS2(1)	10330878	10	10	10	1	0	6	4	0	0	0	0.43	0.62
429	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRB2(1), CHRM2(1), CHRM5(2), DRD1(1), DRD5(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1)	12206396	12	12	12	3	1	6	3	1	1	0	0.44	0.62
430	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(1), ATP5A1(1), ATP5G2(1), ATP6AP1(1), ATP6V0A4(1), ATP6V0D2(1), ATP6V1B1(1), ATP6V1B2(1), COX15(1), COX6A2(1), COX7A2(1), NDUFA10(1), NDUFA13(3), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFS5(1), NDUFV2(1), PPA2(2), SDHA(1), SDHD(1), UQCRC2(1)	27603400	29	27	29	14	7	8	12	0	2	0	0.44	0.62
431	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), MNAT1(1), XPO1(2)	4251172	4	4	4	1	1	0	2	1	0	0	0.44	0.62
432	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGP2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1)	12253964	13	13	13	2	2	4	4	1	2	0	0.44	0.63
433	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNB1(2), HRAS(2), ITGA1(1), ITGB1(2), PLCB1(1), PTK2(1), SYK(1)	11956135	12	11	12	6	1	1	7	0	3	0	0.44	0.63
434	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(3), LEPR(1), PRKAG1(2), PRKAG2(1)	7140097	7	7	7	0	2	1	2	1	1	0	0.44	0.63
435	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(1), FYN(1), LRP8(1), RELN(3), VLDLR(2)	6826972	8	7	8	6	1	4	3	0	0	0	0.44	0.63
436	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(3), ADH5(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), DLAT(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(1), ME3(1), PCK1(2)	17986634	19	17	19	6	4	3	5	3	4	0	0.45	0.63
437	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN2(2), CAPN1(1), ITGA1(1), ITGB1(2), PTK2(1), SPTAN1(1), TLN1(3)	14281837	12	12	12	8	2	2	6	0	2	0	0.45	0.63
438	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), GNB1(2), HRAS(2), MAP2K3(2), MAP3K1(1), NCF1(1), NFATC2(1), NFATC3(2), PAK1(1), PIK3C2G(1), PLCB1(1), PPP3CC(1), RELA(1)	18855704	18	17	18	5	1	4	9	0	4	0	0.45	0.63
439	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(1), SHMT1(1), SHMT2(2)	8840957	8	8	8	1	1	1	5	0	1	0	0.45	0.63
440	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH5(1), ADHFE1(1), AGK(3), ALDH1B1(2), ALDH3A2(1), CEL(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), GK(1), GLB1(3), LCT(1), LIPC(1), LIPF(1), PNLIP(2), PNLIPRP2(1), PNPLA3(1), PPAP2C(1)	28674109	26	23	26	6	4	4	12	2	4	0	0.45	0.63
441	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), F12(1), F2(2), F5(3), F8(1), FGA(1), PROC(2), SERPING1(2)	22068126	22	21	22	11	1	9	10	1	1	0	0.46	0.63
442	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	GGT1(2), MARS(1), PAPSS2(1)	6052156	4	4	4	3	0	1	1	1	1	0	0.46	0.63
443	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1)	5997941	6	6	6	1	1	1	4	0	0	0	0.46	0.63
444	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), ANPEP(3), ENPEP(1), LNPEP(2), MAS1(1), MME(1), REN(1)	10314524	10	10	10	5	4	3	2	0	1	0	0.46	0.63
445	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IRAK1(2), MAP3K1(1), MAP3K7(1), RELA(1), RIPK1(1), TLR4(1), TNFRSF1A(1), TRADD(1), TRAF6(1)	11860348	10	9	10	6	1	0	5	0	4	0	0.46	0.63
446	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CTPS(1), DCTD(1), DPYS(1), POLD1(2), POLE(1), POLL(1), POLQ(3), POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1), RRM2(1), TK2(1), UNG(2)	28285743	21	20	21	7	3	3	8	1	6	0	0.46	0.64
447	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), SDHA(1), SDHD(1)	3201878	3	3	3	0	1	1	0	0	1	0	0.47	0.64
448	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), RPL19(1), RPL27(1), RPL30(1), RPL31(1), RPL34(1), RPL7(1), RPS13(1), RPS26(1), RPS29(1), RPS3A(1)	10851359	11	10	11	4	0	5	5	0	1	0	0.47	0.64
449	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(1), B3GNT5(1), B4GALT4(2), FUT6(1), GCNT2(1), ST3GAL6(1), ST8SIA1(1)	7359256	8	7	8	2	1	3	2	1	1	0	0.47	0.64
450	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSD(1), ARSE(1), CYP11B2(1), HSD17B2(1), HSD17B8(1), STS(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1)	12758150	12	12	12	5	1	3	5	1	2	0	0.47	0.65
451	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1), B3GNT5(1), ST3GAL3(1)	3498397	3	3	3	1	0	0	1	1	1	0	0.48	0.65
452	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(3), HEXA(1), LCT(1), SLC33A1(2), ST8SIA1(1)	8074688	9	8	9	6	1	4	2	1	1	0	0.48	0.65
453	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), HADHA(1)	2398269	2	2	2	0	0	1	1	0	0	0	0.48	0.65
454	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), IARS2(2), VARS2(4)	8400540	8	8	8	3	1	2	4	0	1	0	0.48	0.65
455	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1)	1597225	1	1	1	1	0	0	0	0	1	0	0.49	0.66
456	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2J2(1), PLA2G12A(1), PLA2G6(2), RDH13(1)	11771519	11	11	11	1	3	1	5	1	1	0	0.49	0.66
457	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1B1(2), ALDH3A2(1)	3929942	4	4	4	1	1	0	3	0	0	0	0.49	0.66
458	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1B1(2), ALDH3A2(1)	3929942	4	4	4	1	1	0	3	0	0	0	0.49	0.66
459	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS2(1), SULT1A2(1), SUOX(1)	2978406	3	3	3	2	0	2	0	1	0	0	0.49	0.66
460	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), EP300(3), NCOA1(1), NCOA2(1)	9063247	8	8	8	6	1	1	5	0	1	0	0.49	0.66
461	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1), RDH5(1)	1902186	2	2	2	2	1	0	1	0	0	0	0.49	0.66
462	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ITPKA(1), PDE1B(2), PLCB1(1), PLCB2(1)	5458098	5	5	5	2	1	1	1	0	2	0	0.49	0.66
463	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(1), HADHA(1), HADHB(2)	4127565	4	4	4	1	2	1	1	0	0	0	0.49	0.66
464	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADS(2), ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1), CYP4A11(2), CYP4A22(1), ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1)	24016108	23	23	23	11	6	4	11	0	2	0	0.50	0.67
465	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), MYST3(4), PNPLA3(1)	7809532	6	6	6	2	0	3	3	0	0	0	0.51	0.67
466	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(1), SHMT1(1), SHMT2(2)	9294309	8	8	8	1	1	1	5	0	1	0	0.51	0.68
467	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), HRAS(2), JUN(1), PLCB1(1), RELA(1)	7475440	6	6	6	3	1	1	3	0	1	0	0.52	0.68
468	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UCHL3(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1)	7945896	8	8	8	3	2	2	1	1	2	0	0.52	0.69
469	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(1), MPI(1)	6668597	7	6	7	3	0	3	3	1	0	0	0.52	0.69
470	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(1), NR1H4(1)	2623419	2	2	2	3	0	0	1	1	0	0	0.52	0.69
471	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(1), HMGCR(1), PMVK(1), VKORC1(1)	5481897	5	5	5	0	0	2	3	0	0	0	0.53	0.69
472	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1)	2118540	2	2	2	0	0	2	0	0	0	0	0.53	0.69
473	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), FBP1(1), FPGT(1), HK1(3), KHK(2), MPI(1), PFKM(2)	11887077	11	10	11	6	0	4	4	2	1	0	0.53	0.70
474	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), GNB1(2), PRKACB(1)	4611498	4	4	4	4	0	1	3	0	0	0	0.54	0.70
475	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(2), IL6R(1), TGFB2(1), TNFRSF1A(1)	6677849	6	6	6	5	2	0	2	0	2	0	0.54	0.70
476	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	CALM2(1), HRAS(2), JUN(1), MAP3K1(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1), SOS1(4), SYK(1), VAV1(1)	18528652	16	16	16	10	1	5	7	0	3	0	0.55	0.70
477	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), COX15(1), CP(1), EPRS(1), FECH(1), FTMT(2), GUSB(2), HMOX1(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1)	19666031	20	19	20	5	6	4	5	1	4	0	0.55	0.70
478	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	CALM2(1), GNAS(1), GNB1(2), HRAS(2), JUN(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1), PRKACB(1), RPS6KA3(1)	16651595	14	14	14	6	1	5	7	0	1	0	0.55	0.70
479	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), PER1(2), PER2(1), PER3(2)	8363050	7	7	7	2	0	3	2	0	2	0	0.55	0.70
480	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(1), POLL(1), POLQ(3)	8338612	7	7	7	2	2	1	2	0	2	0	0.55	0.70
481	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS2(2)	2589307	2	2	2	2	0	1	0	0	1	0	0.55	0.70
482	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), EP300(3)	7476649	6	6	6	6	0	1	4	0	1	0	0.55	0.70
483	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	1656909	1	1	1	1	0	0	0	0	1	0	0.56	0.71
484	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI2(1)	2173785	2	2	2	0	0	1	1	0	0	0	0.56	0.72
485	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDKN1A(1), WEE1(1)	3712484	3	3	3	1	0	2	1	0	0	0	0.57	0.72
486	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP5(1), ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), DHRS2(1)	8505842	8	7	8	4	0	2	5	0	1	0	0.57	0.73
487	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYS(1), ENPP3(2), PANK2(2)	6682716	7	6	7	1	1	1	4	1	0	0	0.57	0.73
488	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1)	6580023	6	6	6	2	2	0	3	0	1	0	0.58	0.73
489	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	1499385	1	1	1	1	0	0	1	0	0	0	0.58	0.73
490	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(1), ALG13(1), ALG3(1), ALG8(1), DOLPP1(1), DPAGT1(1), MAN1A2(1), MAN2A1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RFT1(1), RPN1(2), RPN2(1), STT3B(1)	20673936	17	16	17	5	0	4	9	1	3	0	0.58	0.73
491	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	EPHB2(1), F2(2), JUN(1), PLD1(1), PLD2(1), PLD3(1), PTK2(1), RASAL1(1), TEC(1), VAV1(1)	13680040	11	11	11	9	0	1	8	0	2	0	0.58	0.73
492	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CCKAR(2), CCKBR(1), MC3R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(1), OPRM1(1), SSTR1(2), SSTR4(1), TACR1(1), TACR2(1), TACR3(2), TSHR(1)	24748948	22	21	22	9	2	6	12	0	2	0	0.58	0.73
493	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	FADS2(1), PLA2G12A(1), PLA2G6(2)	5086502	4	4	4	0	0	0	4	0	0	0	0.58	0.73
494	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), GRM1(1), PLCB1(1), PPP2CA(2), PRKACB(1)	7761224	6	6	6	0	0	1	3	0	2	0	0.59	0.73
495	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), ITGAL(2)	4112732	3	3	3	1	0	0	2	0	1	0	0.60	0.74
496	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACSL1(1), ACSL3(1), HADHA(1), PECR(1), SCP2(2)	8243036	8	8	8	7	1	3	4	0	0	0	0.60	0.75
497	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1)	1852755	1	1	1	1	0	0	0	1	0	0	0.60	0.75
498	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(1), MEF2A(1)	4121456	3	3	3	1	1	0	0	0	2	0	0.60	0.75
499	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKACB(1), PRKAG1(2)	4969151	4	4	4	1	0	2	2	0	0	0	0.60	0.75
500	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL16(2), IL3(1)	4730628	4	4	4	3	1	1	2	0	0	0	0.61	0.75
501	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), IFNB1(1), RELA(1), TRAF6(1)	5365496	4	4	4	2	0	1	2	0	1	0	0.61	0.75
502	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ADH1B(1), ADH5(1), ADHFE1(1), DHRS2(1), MYST3(4), PNPLA3(1)	11968492	9	9	9	4	2	3	3	0	1	0	0.61	0.75
503	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1B1(2), ALDH3A2(1), CYP2C19(1), DHRS2(1), ECHS1(1), HADHA(1), MYST3(4), PNPLA3(1)	14912116	12	11	12	2	0	4	7	1	0	0	0.61	0.75
504	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(1), ADH5(1), ADHFE1(1), AKR1C1(1), ALDH3B1(1), ALDH3B2(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), DHDH(2), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1)	27113692	24	22	24	7	6	3	8	3	4	0	0.62	0.75
505	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1)	1645680	1	1	1	0	0	0	1	0	0	0	0.62	0.75
506	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), IMPDH1(1), POLD1(2), PRPS2(1)	6298961	5	5	5	2	1	1	3	0	0	0	0.62	0.76
507	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	HRAS(2), JUN(1), MAP3K1(1), MAPK8IP3(1), RPS6KA1(1), RPS6KA3(1), SOS1(4), SYK(1), VAV1(1), VAV3(1)	15453816	14	13	14	3	2	3	7	0	2	0	0.62	0.76
508	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(1)	1831849	1	1	1	1	0	1	0	0	0	0	0.62	0.76
509	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	XYLT1(1), XYLT2(1)	3182878	2	2	2	1	0	1	1	0	0	0	0.63	0.76
510	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	XYLT1(1), XYLT2(1)	3182878	2	2	2	1	0	1	1	0	0	0	0.63	0.76
511	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADHFE1(1)	2757591	2	2	2	2	1	0	0	0	1	0	0.63	0.76
512	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), GNAS(1), GNB1(2), HRAS(2), PRKACB(1), RPS6KA1(1)	9923836	8	8	8	3	1	2	5	0	0	0	0.63	0.76
513	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	CALM2(1), CAMK2G(2), CLCA4(1), CNGA4(1), GNAL(1), GUCA1B(1), PDE1C(1), PRKACA(1), PRKACB(1), PRKG1(1), PRKG2(1)	15177282	12	12	12	5	2	1	6	2	1	0	0.63	0.76
514	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(1), HMGCR(1), PMVK(1), SC4MOL(1)	6541540	5	5	5	0	0	1	3	0	1	0	0.63	0.76
515	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IRAK1(2), IRAK3(1), JUN(1), MAP2K3(2), MAP3K1(1), MAP3K7(1), RELA(1), TGFB2(1), TGFB3(1), TRAF6(1)	14495990	13	11	13	2	2	1	7	0	3	0	0.64	0.76
516	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B1(1), HSD17B2(1), HSD17B4(1)	3943716	3	3	3	2	0	1	1	1	0	0	0.65	0.77
517	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), RENBP(2)	8352039	8	7	8	1	0	4	3	1	0	0	0.65	0.78
518	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CLK2(1), CLK4(1), COL2A1(3), CPSF1(2), CPSF2(1), CPSF3(1), CSTF2T(1), CSTF3(3), DHX15(2), DHX8(1), DHX9(1), LSM7(1), METTL3(1), NONO(2), POLR2A(4), PRPF8(6), SF3A2(1), SF3B1(2), SF3B2(2), SFRS12(2), SRPK2(1), SRRM1(1), SUPT5H(2), XRN2(2)	51502543	44	41	44	11	7	15	14	3	5	0	0.66	0.78
519	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CD4(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL4R(1), TGFB2(1), TGFB3(1)	9682820	8	8	8	2	2	5	1	0	0	0	0.66	0.78
520	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), IFNB1(1), IL3(1), ITGAX(1), TLR4(1), TLR7(1)	9114542	8	8	8	4	3	1	4	0	0	0	0.66	0.78
521	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD4(1)	1438965	1	1	1	1	0	1	0	0	0	0	0.66	0.78
522	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	CARS(2), DARS(1), EPRS(1), HARS(1), IARS(1), KARS(1), MARS(1), SARS(2), TARS(1)	15693646	11	11	11	7	1	2	6	0	2	0	0.66	0.78
523	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(1), CLTA(1), COPA(1), GBF1(2), KDELR2(1)	7965354	7	7	7	2	1	3	2	0	1	0	0.67	0.79
524	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA4(1), PSMA6(1)	4108699	3	3	3	1	1	0	1	1	0	0	0.67	0.79
525	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	SNAP23(1), STX10(1), STX7(1), STX8(1), TSNARE1(1)	8015575	5	5	5	2	1	1	2	0	1	0	0.67	0.79
526	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK2G(2), ESRRA(1), MEF2A(1), PPP3CC(1)	10231760	7	7	7	1	0	1	3	0	3	0	0.68	0.79
527	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), NFAT5(1), PDE6C(2)	17830422	13	13	13	4	0	6	6	0	1	0	0.68	0.79
528	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), REN(1)	12783227	11	11	11	5	2	4	4	1	0	0	0.68	0.79
529	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), CEL(1), HADHB(2), SOAT2(1)	11495128	10	10	10	5	5	0	3	0	2	0	0.68	0.79
530	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), DAXX(2), HSPB2(1)	5439787	4	4	4	0	3	0	1	0	0	0	0.69	0.80
531	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CALM2(1), EP300(3), NFATC2(1), PPP3CC(1)	11543941	9	9	9	7	0	3	3	1	2	0	0.69	0.80
532	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ACADS(2), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), BDH1(1), ECHS1(1), GAD1(1), HADH(1), HADHA(1), HSD17B4(1), OXCT1(1), RDH13(1)	20122395	16	16	16	7	2	3	9	0	2	0	0.69	0.80
533	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACADS(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), GAD1(1), HADHA(1), OXCT1(1)	12688083	10	10	10	4	1	1	7	0	1	0	0.70	0.80
534	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(1), CALM2(1), PPP3CC(1), SYNJ1(4)	11127707	7	7	7	6	0	2	3	0	2	0	0.70	0.81
535	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAS(1), GNB1(2), HRAS(2), NOX1(1), PIK3C2G(1), PLCB1(1), PPP1R12B(1), PTK2(1)	12524412	10	10	10	5	1	2	6	0	1	0	0.71	0.82
536	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(1)	3378168	2	2	2	1	0	1	1	0	0	0	0.71	0.82
537	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	DHRS2(1), ECHS1(1), HADHA(1), MYST3(4), PNPLA3(1)	12436744	8	8	8	2	0	4	4	0	0	0	0.72	0.83
538	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC2(1), ARPC3(1), NCKAP1(1), WASL(2)	7609349	6	6	6	2	1	2	3	0	0	0	0.72	0.83
539	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), EGR2(1), EGR3(1), MAP3K1(1), NFATC2(1), PLCG1(1), PPP3CC(1), PRKACB(1), RELA(1)	13247491	9	9	9	1	0	2	5	0	2	0	0.73	0.83
540	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(3), EP300(3), MAP2K3(2), MAP3K7(1), RELA(1), TGFBR2(2)	14552743	12	11	12	4	3	1	6	0	2	0	0.73	0.84
541	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), FDPS(1), HMGCR(1), IDI2(1), PMVK(1), SC4MOL(1), VKORC1(1)	9544279	7	7	7	1	0	3	3	0	1	0	0.73	0.84
542	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	CHPT1(1), PAFAH1B1(1), PLA2G12A(1), PLA2G6(2), PLD1(1), PLD2(1), PPAP2C(1)	11433514	8	8	8	2	0	1	6	0	1	0	0.74	0.84
543	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADRB2(1), GNAS(1), PLCE1(1), PRKACB(1), RAP2B(1)	7019869	5	5	5	2	0	3	1	0	1	0	0.74	0.84
544	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CD97(1), CRHR2(1), ELTD1(1), GIPR(1), GLP2R(1), LPHN1(1), LPHN3(3)	13618233	11	10	11	2	1	3	6	0	1	0	0.74	0.84
545	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(1), EPRS(1), FECH(1), GUSB(2), HMOX1(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1)	12759751	11	11	11	4	5	2	1	1	2	0	0.74	0.84
546	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2)	3710742	2	2	2	0	0	1	1	0	0	0	0.74	0.84
547	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	PAPSS2(1), SULT1A2(1), SUOX(1)	4452086	3	3	3	3	0	2	0	1	0	0	0.75	0.84
548	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), FECH(1)	3797446	2	2	2	2	1	0	0	0	1	0	0.75	0.84
549	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(1), MAP3K1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1)	11081882	6	6	6	2	0	2	2	0	2	0	0.75	0.84
550	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	SNCAIP(1), UBE2E2(1)	3102891	2	2	2	1	1	1	0	0	0	0	0.75	0.84
551	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	GCNT2(1), ST8SIA1(1)	2939076	2	2	2	2	1	0	1	0	0	0	0.75	0.84
552	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	1862712	1	1	1	0	0	0	1	0	0	0	0.75	0.84
553	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ITPKA(1), ITPKB(1)	2855343	2	2	2	1	0	2	0	0	0	0	0.76	0.84
554	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1)	2601171	1	1	1	2	0	0	1	0	0	0	0.76	0.84
555	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR45(1), GPR65(1), GPR81(1)	4848662	3	3	3	2	0	1	2	0	0	0	0.76	0.85
556	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CSK(1), PTPRA(1)	4568919	3	3	3	3	0	1	2	0	0	0	0.76	0.85
557	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), IL3(1)	3068160	2	2	2	2	1	1	0	0	0	0	0.77	0.85
558	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ADH1B(1), ADH5(1), ADHFE1(1), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), CEL(1), HADHB(2), RDH13(1), SOAT2(1)	15762123	13	12	13	4	6	0	4	0	3	0	0.77	0.85
559	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM2(1), CDKN1A(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1)	9931680	7	7	7	6	0	4	2	0	1	0	0.77	0.85
560	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), HRAS(2), JUN(1), NCOR2(3), RBL2(1), SIN3A(1)	12945129	9	9	9	1	2	1	6	0	0	0	0.77	0.85
561	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), OXCT1(1)	3554023	2	2	2	1	1	0	0	0	1	0	0.77	0.85
562	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYS(1), ENPP3(2), PANK2(2)	8385050	7	6	7	2	1	1	4	1	0	0	0.77	0.85
563	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BIRC2(2), BIRC3(1), CASP7(1), CASP8(1)	6680587	5	5	5	2	2	1	2	0	0	0	0.77	0.85
564	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(1), RELA(1)	4051481	2	2	2	2	0	0	1	0	1	0	0.78	0.85
565	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), HADHA(1)	3853368	2	2	2	0	0	1	1	0	0	0	0.78	0.85
566	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP5(1), ARHGEF11(1), ARHGEF5(2), ARPC2(1), ARPC3(1), DIAPH1(1), MYLK(2), PPP1R12B(1), ROCK1(2), TLN1(3), VCL(1)	22850648	17	16	17	3	3	5	7	1	1	0	0.79	0.86
567	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(2), ARHGEF11(1), GNA13(1), MAP3K1(1), MAP3K5(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PIK3CB(1), PLD1(1), PLD2(1), PLD3(1), PTK2(1), ROCK1(2), SERPINA4(1)	23773686	19	18	19	6	1	7	8	1	2	0	0.79	0.86
568	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(3), CD19(1), CD1B(1), CD22(2), CD34(1), CD38(1), CD4(1), CD44(2), CD55(1), CR1(2), CR2(2), CSF1R(1), CSF3R(1), FLT3(1), GP1BA(1), HLA-DRA(1), HLA-DRB1(3), IL1R2(1), IL3(1), IL4R(1), IL6R(1), ITGA1(1), ITGA3(2), ITGA6(2), KITLG(1), MME(1), TPO(1)	39789370	37	31	37	19	5	12	12	1	7	0	0.80	0.86
569	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), NOS3(1), REN(1)	4732682	3	3	3	2	2	1	0	0	0	0	0.80	0.87
570	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT2(1), B3GALT4(1), B3GNT3(1), B3GNT5(1), B4GALT4(2), B4GALT6(1), FUT6(1), GCNT2(1), PIGG(1), PIGK(1), PIGM(1), PIGN(1), PIGO(1), PIGQ(2), PIGU(1), ST3GAL3(1), ST3GAL6(1), ST8SIA1(1)	23661756	20	18	20	5	3	6	6	1	4	0	0.80	0.87
571	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT2(1), DSE(1), XYLT1(1), XYLT2(1)	6781104	4	4	4	3	0	2	2	0	0	0	0.81	0.87
572	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	RELA(1), TRAF3(1), TRAF5(1), TRAF6(1)	7233248	4	4	4	2	0	1	2	0	1	0	0.82	0.88
573	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6AP1(1), ATP6V0A4(1), ATP6V0D2(1), ATP6V1B1(1), ATP6V1B2(1), CSK(1), EGFR(4), F11R(1), GIT1(2), JUN(1), MAPK10(1), MAPK9(1), MET(1), NOD1(1), PAK1(1), PLCG1(1), PLCG2(1), PTPN11(1), PTPRZ1(3), RELA(1), TJP1(1)	34666598	28	26	28	10	3	10	13	0	2	0	0.82	0.89
574	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CTPS(1), DCTD(1), DPYS(1), NT5C1B(1), NT5C3(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1), PRIM2(1), RRM2(1), TK2(1), UPP2(1), UPRT(1)	40406257	32	30	30	11	3	10	12	1	6	0	0.83	0.89
575	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ELOVL2(1), FADS2(1), HADHA(1), PECR(1)	6478509	4	4	4	0	0	2	2	0	0	0	0.83	0.89
576	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP72(2)	3688758	2	2	2	2	0	1	1	0	0	0	0.83	0.89
577	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDH1(2), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(3), ROCK1(2), TLR4(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1), WASL(2)	25174071	20	19	20	16	3	7	7	1	2	0	0.84	0.89
578	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDH1(2), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(3), ROCK1(2), TLR4(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1), WASL(2)	25174071	20	19	20	16	3	7	7	1	2	0	0.84	0.89
579	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), FDXR(1), SHMT1(1)	7926774	6	5	6	4	0	2	3	0	1	0	0.84	0.90
580	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(1), MAP3K1(1), RELA(1), TRAF3(1), TRAF6(1)	9029476	5	5	5	2	0	2	1	0	2	0	0.85	0.90
581	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(1)	4354661	2	2	2	1	0	1	1	0	0	0	0.85	0.90
582	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(1)	4354661	2	2	2	1	0	1	1	0	0	0	0.85	0.90
583	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), CES1(3), CES2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1)	11174776	9	8	9	3	2	3	2	1	1	0	0.86	0.91
584	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	DNMT1(2), DNMT3A(2), MARS(1)	8578032	5	5	5	4	0	3	2	0	0	0	0.86	0.91
585	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), HMGB2(1), TOP2A(1)	5126406	3	3	3	1	1	1	0	0	1	0	0.88	0.92
586	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA4(1), PSMA6(1), PSMD1(1), PSMD11(1), PSMD2(1)	7882835	6	5	6	3	1	0	3	2	0	0	0.88	0.92
587	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	DNMT1(2), DNMT3A(2), MARS(1), MTAP(1)	10229229	6	6	6	5	0	4	2	0	0	0	0.89	0.93
588	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3)	4975759	3	2	3	0	0	1	1	1	0	0	0.89	0.94
589	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(3), OLAH(1)	7200836	4	4	4	1	2	0	0	1	1	0	0.90	0.94
590	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1)	4924924	2	2	2	1	0	0	2	0	0	0	0.90	0.94
591	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	ST3GAL3(1)	3812383	1	1	1	1	0	0	0	0	1	0	0.91	0.94
592	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1)	2469991	1	1	1	3	0	0	1	0	0	0	0.91	0.95
593	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1)	5114696	2	2	2	0	0	0	2	0	0	0	0.92	0.95
594	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1)	7491671	5	4	5	4	0	2	2	0	1	0	0.92	0.95
595	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1)	7491671	5	4	5	4	0	2	2	0	1	0	0.92	0.95
596	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1)	7491671	5	4	5	4	0	2	2	0	1	0	0.92	0.95
597	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY9(2), ARF1(1), ATP6V0A4(1), ATP6V0D2(1), ERO1L(1), GNAS(1), PLCG1(1), PLCG2(1), SEC61B(1), TRIM23(1)	18073423	11	11	11	9	0	5	6	0	0	0	0.93	0.96
598	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3)	5623104	3	2	3	0	0	1	1	1	0	0	0.93	0.96
599	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	CES1(3)	5632490	3	3	3	3	1	2	0	0	0	0	0.94	0.96
600	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	HEXA(1), ST8SIA1(1)	4825521	2	2	2	2	1	1	0	0	0	0	0.95	0.97
601	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGG(1), PIGK(1), PIGM(1), PIGN(1), PIGO(1), PIGQ(2), PIGU(1)	12115980	8	7	8	1	2	3	2	0	1	0	0.96	0.98
602	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	HEXA(1), ST8SIA1(1)	5125130	2	2	2	2	1	1	0	0	0	0	0.96	0.98
603	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IRAK1(2), JUN(1), MAP2K3(2), MAP3K1(1), MAP3K7(1), RELA(1), TLR10(1), TLR4(1), TLR6(1), TLR7(1), TRAF6(1)	17920265	13	10	13	4	3	0	6	1	3	0	0.97	0.99
604	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXTL3(1), GLCE(1), HS6ST3(1), NDST4(1)	10206650	5	5	5	1	1	1	3	0	0	0	0.97	0.99
605	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	CDS2(1), CHPT1(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), MYST3(4), PLA2G12A(1), PLA2G6(2), PLD1(1), PLD2(1), PNPLA3(1), PPAP2C(1)	32286546	17	16	17	6	1	4	11	0	1	0	0.98	1.00
606	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	CDS2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), PAFAH1B1(1), PLA2G6(2), PLCB2(1), PLCG1(1), PLCG2(1), PPAP2C(1)	24464749	12	12	12	3	1	2	8	0	1	0	0.99	1.00
607	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8		3461122	0	0	0	2	0	0	0	0	0	0	1.00	1.00
608	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		770288	0	0	0	0	0	0	0	0	0	0	1.00	1.00
609	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		247866	0	0	0	1	0	0	0	0	0	0	1.00	1.00
610	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		906038	0	0	0	1	0	0	0	0	0	0	1.00	1.00
611	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		1054317	0	0	0	1	0	0	0	0	0	0	1.00	1.00
612	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1533192	0	0	0	1	0	0	0	0	0	0	1.00	1.00
613	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5		2372078	0	0	0	0	0	0	0	0	0	0	1.00	1.00
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		830307	0	0	0	0	0	0	0	0	0	0	1.00	1.00
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		568246	0	0	0	0	0	0	0	0	0	0	1.00	1.00
616	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7		2713275	0	0	0	1	0	0	0	0	0	0	1.00	1.00
