E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.029 0.142 -9999.0 0.0 -0.405 13.0 13.0 KLHL20 -0.01 0.109 0.201 1.0 -0.28 11.0 12.0 CYFIP2 0.025 0.049 -9999.0 0.0 -0.518 1.0 1.0 Rac1/GDP -0.001 0.109 0.342 1.0 -0.284 7.0 8.0 ENAH -0.03 0.147 -9999.0 0.0 -0.412 14.0 14.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.066 -9999.0 0.0 -0.518 2.0 2.0 CTNNB1 0.028 0.017 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.079 -9999.0 0.0 -0.232 1.0 1.0 ABI1/Sra1/Nap1 -0.032 0.059 -9999.0 0.0 -0.19 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.088 -9999.0 0.0 -0.296 7.0 7.0 RAPGEF1 -0.021 0.135 0.343 1.0 -0.388 10.0 11.0 CTNND1 0.025 0.066 -9999.0 0.0 -0.518 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.153 -9999.0 0.0 -0.421 14.0 14.0 CRK -0.016 0.137 -9999.0 0.0 -0.399 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.02 0.124 -9999.0 0.0 -0.345 13.0 13.0 alphaE/beta7 Integrin 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.047 -9999.0 0.0 -0.295 2.0 2.0 DLG1 -0.017 0.109 -9999.0 0.0 -0.376 9.0 9.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.044 -9999.0 0.0 -0.258 2.0 2.0 MLLT4 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.058 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.011 0.057 -9999.0 0.0 -0.34 2.0 2.0 ARF6 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.001 0.135 -9999.0 0.0 -0.382 14.0 14.0 TIAM1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.043 0.091 -9999.0 0.0 -0.278 9.0 9.0 AKT1 -0.001 0.044 -9999.0 0.0 -0.191 2.0 2.0 PIK3R1 0.004 0.097 -9999.0 0.0 -0.518 4.0 4.0 CDH1 0.002 0.122 -9999.0 0.0 -0.518 7.0 7.0 RhoA/GDP 0.005 0.107 0.342 1.0 -0.281 7.0 8.0 actin cytoskeleton organization -0.004 0.081 0.152 2.0 -0.211 9.0 11.0 CDC42/GDP 0.002 0.11 0.342 1.0 -0.284 7.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.011 0.097 -9999.0 0.0 -0.274 15.0 15.0 ITGB7 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.047 0.097 -9999.0 0.0 -0.296 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.076 -9999.0 0.0 -0.275 7.0 7.0 mol:GDP -0.016 0.115 0.349 1.0 -0.32 8.0 9.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.003 0.122 -9999.0 0.0 -0.518 7.0 7.0 p120 catenin/RhoA/GDP 0.01 0.115 0.347 1.0 -0.287 9.0 10.0 RAC1/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.039 -9999.0 0.0 -0.378 1.0 1.0 RHOA 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.076 0.127 1.0 -0.232 10.0 11.0 NME1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.034 0.149 -9999.0 0.0 -0.407 15.0 15.0 regulation of cell-cell adhesion -0.004 0.062 -9999.0 0.0 -0.197 8.0 8.0 WASF2 -0.003 0.043 0.094 1.0 -0.124 5.0 6.0 Rap1/GTP 0.012 0.092 0.317 1.0 -0.245 8.0 9.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.121 -9999.0 0.0 -0.301 13.0 13.0 CCND1 -0.01 0.094 0.146 1.0 -0.292 10.0 11.0 VAV2 -0.043 0.228 -9999.0 0.0 -0.599 15.0 15.0 RAP1/GDP 0.013 0.099 0.349 1.0 -0.256 4.0 5.0 adherens junction assembly -0.032 0.145 -9999.0 0.0 -0.394 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.049 -9999.0 0.0 -0.518 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.027 0.111 -9999.0 0.0 -0.29 13.0 13.0 E-cadherin/beta catenin -0.007 0.087 -9999.0 0.0 -0.346 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.031 0.145 -9999.0 0.0 -0.417 13.0 13.0 PIK3CA 0.011 0.048 -9999.0 0.0 -0.518 1.0 1.0 Rac1/GTP -0.064 0.156 -9999.0 0.0 -0.461 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.036 0.088 -9999.0 0.0 -0.322 7.0 7.0 ITGAE 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.156 -9999.0 0.0 -0.43 14.0 14.0