E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.01 0.104 -9999.0 0.0 -0.412 26.0 26.0 KLHL20 -0.026 0.089 -9999.0 0.0 -0.211 42.0 42.0 CYFIP2 -0.003 0.086 -9999.0 0.0 -0.306 38.0 38.0 Rac1/GDP 0.026 0.077 -9999.0 0.0 -0.257 27.0 27.0 ENAH 0.002 0.113 -9999.0 0.0 -0.431 27.0 27.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 112.0 112.0 RAP1A 0.015 0.039 -9999.0 0.0 -0.319 7.0 7.0 CTNNB1 0.012 0.054 -9999.0 0.0 -0.365 11.0 11.0 CDC42/GTP -0.015 0.047 -9999.0 0.0 -0.248 12.0 12.0 ABI1/Sra1/Nap1 -0.038 0.05 -9999.0 0.0 -0.145 59.0 59.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.08 -9999.0 0.0 -0.204 50.0 50.0 RAPGEF1 0.016 0.096 -9999.0 0.0 -0.367 26.0 26.0 CTNND1 0.006 0.07 -9999.0 0.0 -0.356 19.0 19.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.106 -9999.0 0.0 -0.434 25.0 25.0 CRK 0.01 0.103 -9999.0 0.0 -0.401 26.0 26.0 E-cadherin/gamma catenin/alpha catenin 0.017 0.072 -9999.0 0.0 -0.209 46.0 46.0 alphaE/beta7 Integrin 0.006 0.072 -9999.0 0.0 -0.244 35.0 35.0 IQGAP1 -0.01 0.1 -9999.0 0.0 -0.333 46.0 46.0 NCKAP1 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 Rap1/GTP/I-afadin 0.022 0.021 -9999.0 0.0 -0.183 5.0 5.0 DLG1 0.009 0.103 -9999.0 0.0 -0.417 25.0 25.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.022 0.047 -9999.0 0.0 -0.186 28.0 28.0 MLLT4 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.011 0.045 -9999.0 0.0 -0.183 19.0 19.0 PI3K -0.028 0.061 -9999.0 0.0 -0.239 28.0 28.0 ARF6 0.017 0.033 -9999.0 0.0 -0.365 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.0 208.0 208.0 E-cadherin/gamma catenin 0.009 0.072 -9999.0 0.0 -0.257 34.0 34.0 TIAM1 -0.003 0.079 -9999.0 0.0 -0.259 44.0 44.0 E-cadherin(dimer)/Ca2+ 0.024 0.068 -9999.0 0.0 -0.18 49.0 49.0 AKT1 0.007 0.055 -9999.0 0.0 -0.159 31.0 31.0 PIK3R1 -0.011 0.097 -9999.0 0.0 -0.3 52.0 52.0 CDH1 0.009 0.061 -9999.0 0.0 -0.335 16.0 16.0 RhoA/GDP 0.023 0.089 -9999.0 0.0 -0.289 31.0 31.0 actin cytoskeleton organization -0.018 0.067 -9999.0 0.0 -0.154 42.0 42.0 CDC42/GDP 0.029 0.075 -9999.0 0.0 -0.249 26.0 26.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.084 -9999.0 0.0 -0.227 56.0 56.0 ITGB7 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.017 0.033 -9999.0 0.0 -0.365 4.0 4.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.072 -9999.0 0.0 -0.192 49.0 49.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.02 0.053 -9999.0 0.0 -0.174 35.0 35.0 mol:GDP 0.02 0.083 -9999.0 0.0 -0.292 26.0 26.0 CDC42/GTP/IQGAP1 0.009 0.06 -9999.0 0.0 -0.203 37.0 37.0 JUP 0.002 0.079 -9999.0 0.0 -0.346 26.0 26.0 p120 catenin/RhoA/GDP 0.019 0.097 -9999.0 0.0 -0.295 32.0 32.0 RAC1/GTP/IQGAP1 0.007 0.062 -9999.0 0.0 -0.203 41.0 41.0 PIP5K1C/AP1M1 0.014 0.009 -9999.0 0.0 -0.133 2.0 2.0 RHOA -0.008 0.1 -9999.0 0.0 -0.365 39.0 39.0 CDC42 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 CTNNA1 0.01 0.059 -9999.0 0.0 -0.365 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.043 0.087 -9999.0 0.0 -0.162 159.0 159.0 NME1 -0.0 0.0 -9999.0 0.0 -0.001 218.0 218.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.007 0.109 -9999.0 0.0 -0.43 26.0 26.0 regulation of cell-cell adhesion -0.014 0.041 -9999.0 0.0 -0.219 12.0 12.0 WASF2 -0.021 0.027 -9999.0 0.0 -0.078 59.0 59.0 Rap1/GTP 0.019 0.066 -9999.0 0.0 -0.283 12.0 12.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.02 0.085 -9999.0 0.0 -0.305 11.0 11.0 CCND1 -0.054 0.106 -9999.0 0.0 -0.199 159.0 159.0 VAV2 0.014 0.101 -9999.0 0.0 -0.42 19.0 19.0 RAP1/GDP 0.018 0.07 -9999.0 0.0 -0.304 11.0 11.0 adherens junction assembly 0.007 0.106 -9999.0 0.0 -0.417 26.0 26.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.009 0.062 -9999.0 0.0 -0.354 15.0 15.0 PIP5K1C 0.019 0.014 -9999.0 0.0 -0.204 2.0 2.0 regulation of heterotypic cell-cell adhesion 0.019 0.089 -9999.0 0.0 -0.305 18.0 18.0 E-cadherin/beta catenin 0.008 0.049 -9999.0 0.0 -0.281 13.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.001 218.0 218.0 SRC 0.009 0.103 -9999.0 0.0 -0.418 25.0 25.0 PIK3CA -0.011 0.101 -9999.0 0.0 -0.328 48.0 48.0 Rac1/GTP -0.08 0.109 -9999.0 0.0 -0.345 42.0 42.0 E-cadherin/beta catenin/alpha catenin 0.022 0.062 -9999.0 0.0 -0.207 35.0 35.0 ITGAE -0.014 0.102 -9999.0 0.0 -0.305 56.0 56.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.108 -9999.0 0.0 -0.443 25.0 25.0