Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.065 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.034 0.01 -9999.0 0.0 -0.182 1.0 1.0 SHH Np/Cholesterol/GAS1 0.003 0.066 -9999.0 0.0 -0.177 58.0 58.0 LRPAP1 -0.004 0.087 -9999.0 0.0 -0.31 38.0 38.0 dorsoventral neural tube patterning -0.003 0.066 0.176 58.0 -9999.0 0.0 58.0 SMO/beta Arrestin2 0.071 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.064 0.011 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.012 0.121 -9999.0 0.0 -0.44 20.0 20.0 ARRB2 0.018 0.021 -9999.0 0.0 -0.204 5.0 5.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 heart looping 0.064 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.05 0.027 -9999.0 0.0 -0.207 1.0 1.0 DHH N/PTCH2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA -0.011 0.101 -9999.0 0.0 -0.328 48.0 48.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.067 0.015 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.064 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.011 0.097 -9999.0 0.0 -0.3 52.0 52.0 skeletal system development 0.067 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.022 0.005 -9999.0 0.0 -0.091 1.0 1.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.064 0.011 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.019 0.014 -9999.0 0.0 -0.204 2.0 2.0 PI3K -0.014 0.098 -9999.0 0.0 -0.254 66.0 66.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.124 -9999.0 0.0 -0.324 78.0 78.0 somite specification 0.064 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.059 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.014 0.04 -9999.0 0.0 -0.182 1.0 1.0 SHH 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.056 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.069 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip 0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.011 0.077 -9999.0 0.0 -0.204 74.0 74.0 receptor-mediated endocytosis 0.063 0.023 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.063 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.062 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.008 0.078 -9999.0 0.0 -0.249 26.0 26.0 PTCH2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.056 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0