Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.006 0.105 -9999.0 0.0 -0.234 78.0 78.0 epithelial cell differentiation 0.022 0.066 -9999.0 0.0 -0.178 49.0 49.0 CYFIP2 -0.003 0.086 -9999.0 0.0 -0.306 38.0 38.0 ENAH 0.003 0.089 -9999.0 0.0 -0.232 46.0 46.0 EGFR 0.018 0.017 -9999.0 0.0 -0.204 3.0 3.0 EPHA2 -0.003 0.079 -9999.0 0.0 -0.254 45.0 45.0 MYO6 0.008 0.078 -9999.0 0.0 -0.318 19.0 19.0 CTNNB1 0.012 0.054 -9999.0 0.0 -0.365 11.0 11.0 ABI1/Sra1/Nap1 0.02 0.064 -9999.0 0.0 -0.196 39.0 39.0 AQP5 0.01 0.093 -9999.0 0.0 -0.399 17.0 17.0 CTNND1 0.006 0.07 -9999.0 0.0 -0.356 19.0 19.0 mol:PI-4-5-P2 0.018 0.06 -9999.0 0.0 -0.162 49.0 49.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.06 -9999.0 0.0 -0.162 49.0 49.0 EGF 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 NCKAP1 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 AQP3 0.011 0.093 -9999.0 0.0 -0.386 18.0 18.0 cortical microtubule organization 0.022 0.066 -9999.0 0.0 -0.178 49.0 49.0 GO:0000145 0.013 0.056 -9999.0 0.0 -0.155 49.0 49.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.068 -9999.0 0.0 -0.179 49.0 49.0 MLLT4 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.031 0.068 -9999.0 0.0 -0.27 27.0 27.0 ARF6 0.017 0.033 -9999.0 0.0 -0.365 4.0 4.0 Ephrin A1/EPHA2/NCK1/GIT1 0.012 0.084 -9999.0 0.0 -0.192 61.0 61.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.103 -9999.0 0.0 -0.349 26.0 26.0 PVRL2 0.002 0.076 -9999.0 0.0 -0.301 30.0 30.0 ZYX 0.013 0.07 -9999.0 0.0 -0.19 49.0 49.0 ARF6/GTP 0.018 0.082 -9999.0 0.0 -0.177 63.0 63.0 CDH1 0.009 0.061 -9999.0 0.0 -0.335 16.0 16.0 EGFR/EGFR/EGF/EGF 0.02 0.058 -9999.0 0.0 -0.285 7.0 7.0 RhoA/GDP 0.011 0.086 -9999.0 0.0 -0.186 75.0 75.0 actin cytoskeleton organization 0.011 0.077 -9999.0 0.0 -0.32 18.0 18.0 IGF-1R heterotetramer -0.054 0.146 -9999.0 0.0 -0.328 115.0 115.0 GIT1 0.019 0.01 -9999.0 0.0 -0.204 1.0 1.0 IGF1R -0.055 0.146 -9999.0 0.0 -0.328 115.0 115.0 IGF1 -0.07 0.142 -9999.0 0.0 -0.272 166.0 166.0 DIAPH1 0.002 0.161 -9999.0 0.0 -0.578 38.0 38.0 Wnt receptor signaling pathway -0.022 0.066 0.178 49.0 -9999.0 0.0 49.0 RHOA -0.008 0.1 -9999.0 0.0 -0.365 39.0 39.0 RhoA/GTP -0.039 0.081 -9999.0 0.0 -0.291 37.0 37.0 CTNNA1 0.01 0.059 -9999.0 0.0 -0.365 13.0 13.0 VCL 0.011 0.078 -9999.0 0.0 -0.327 18.0 18.0 EFNA1 -0.009 0.097 -9999.0 0.0 -0.313 47.0 47.0 LPP 0.014 0.073 -9999.0 0.0 -0.346 12.0 12.0 Ephrin A1/EPHA2 -0.002 0.082 -9999.0 0.0 -0.298 18.0 18.0 SEC6/SEC8 -0.02 0.056 -9999.0 0.0 -0.295 12.0 12.0 MGAT3 0.018 0.061 -9999.0 0.0 -0.164 49.0 49.0 HGF/MET 0.017 0.061 -9999.0 0.0 -0.28 9.0 9.0 HGF 0.019 0.014 -9999.0 0.0 -0.204 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.006 0.105 -9999.0 0.0 -0.236 78.0 78.0 actin cable formation 0.005 0.102 -9999.0 0.0 -0.262 42.0 42.0 KIAA1543 0.006 0.056 -9999.0 0.0 -0.162 49.0 49.0 KIFC3 0.018 0.061 -9999.0 0.0 -0.164 49.0 49.0 NCK1 0.002 0.074 -9999.0 0.0 -0.285 32.0 32.0 EXOC3 0.016 0.036 -9999.0 0.0 -0.264 8.0 8.0 ACTN1 0.013 0.071 -9999.0 0.0 -0.188 49.0 49.0 NCK1/GIT1 0.016 0.053 -9999.0 0.0 -0.183 33.0 33.0 mol:GDP 0.022 0.066 -9999.0 0.0 -0.178 49.0 49.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.016 0.066 -9999.0 0.0 -0.174 49.0 49.0 PIP5K1C 0.018 0.061 -9999.0 0.0 -0.164 49.0 49.0 LIMA1 -0.019 0.109 -9999.0 0.0 -0.311 63.0 63.0 ABI1 0.009 0.062 -9999.0 0.0 -0.354 15.0 15.0 ROCK1 0.003 0.093 -9999.0 0.0 -0.261 38.0 38.0 adherens junction assembly 0.022 0.057 -9999.0 0.0 -0.284 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.051 0.109 -9999.0 0.0 -0.275 59.0 59.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.054 -9999.0 0.0 -0.244 18.0 18.0 MET 0.012 0.041 -9999.0 0.0 -0.204 19.0 19.0 PLEKHA7 0.006 0.058 -9999.0 0.0 -0.17 49.0 49.0 mol:GTP 0.01 0.083 -9999.0 0.0 -0.191 61.0 61.0 establishment of epithelial cell apical/basal polarity 0.022 0.073 -9999.0 0.0 -0.291 15.0 15.0 cortical actin cytoskeleton stabilization -0.006 0.105 -9999.0 0.0 -0.234 78.0 78.0 regulation of cell-cell adhesion 0.011 0.077 -9999.0 0.0 -0.32 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.006 0.105 -9999.0 0.0 -0.236 78.0 78.0