Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.048 0.028 0.233 1.0 -9999.0 0.0 1.0 KIRREL 0.039 0.013 0.078 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.048 0.028 -9999.0 0.0 -0.233 1.0 1.0 PLCG1 0.035 0.008 -9999.0 0.0 0.0 25.0 25.0 ARRB2 0.034 0.01 -9999.0 0.0 0.0 43.0 43.0 WASL 0.036 0.006 -9999.0 0.0 0.0 16.0 16.0 Nephrin/NEPH1/podocin/CD2AP 0.075 0.054 -9999.0 0.0 -0.153 12.0 12.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.023 0.039 -9999.0 0.0 -0.193 2.0 2.0 FYN 0.03 0.052 0.164 58.0 -0.255 1.0 59.0 mol:Ca2+ 0.076 0.042 -9999.0 0.0 -0.186 1.0 1.0 mol:DAG 0.078 0.043 -9999.0 0.0 -0.187 1.0 1.0 NPHS2 0.041 0.011 0.084 2.0 -0.063 1.0 3.0 mol:IP3 0.078 0.043 -9999.0 0.0 -0.187 1.0 1.0 regulation of endocytosis 0.046 0.057 -9999.0 0.0 -0.244 1.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.061 0.035 0.172 1.0 -0.181 1.0 2.0 establishment of cell polarity 0.048 0.028 -9999.0 0.0 -0.233 1.0 1.0 Nephrin/NEPH1/podocin/NCK1-2 0.083 0.066 -9999.0 0.0 -0.153 16.0 16.0 Nephrin/NEPH1/beta Arrestin2 0.048 0.059 -9999.0 0.0 -0.247 1.0 1.0 NPHS1 0.036 0.016 0.08 5.0 -0.063 1.0 6.0 Nephrin/NEPH1/podocin 0.047 0.057 0.207 2.0 -0.098 48.0 50.0 TJP1 0.034 0.01 -9999.0 0.0 0.0 42.0 42.0 NCK1 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 NCK2 0.036 0.006 -9999.0 0.0 0.0 13.0 13.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.079 0.044 -9999.0 0.0 -0.187 1.0 1.0 CD2AP 0.034 0.01 -9999.0 0.0 0.0 39.0 39.0 Nephrin/NEPH1/podocin/GRB2 0.078 0.049 -9999.0 0.0 -0.174 6.0 6.0 GRB2 0.035 0.007 -9999.0 0.0 0.0 22.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.014 0.068 0.167 73.0 -0.169 1.0 74.0 cytoskeleton organization 0.012 0.046 0.233 10.0 -0.211 1.0 11.0 Nephrin/NEPH1 0.041 0.023 -9999.0 0.0 -0.155 1.0 1.0 Nephrin/NEPH1/ZO-1 0.059 0.04 -9999.0 0.0 -0.182 5.0 5.0