Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.048 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.013 0.05 -9999.0 0.0 -0.146 44.0 44.0 LRPAP1 0.033 0.012 -9999.0 0.0 0.0 58.0 58.0 dorsoventral neural tube patterning -0.013 0.05 0.145 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 0.058 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.037 0.021 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.008 0.124 -9999.0 0.0 -0.406 23.0 23.0 ARRB2 0.034 0.01 -9999.0 0.0 0.0 43.0 43.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.037 0.004 -9999.0 0.0 0.0 5.0 5.0 heart looping 0.037 0.021 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.03 0.047 0.188 39.0 -9999.0 0.0 39.0 DHH N/PTCH2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.026 0.017 -9999.0 0.0 0.0 158.0 158.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.029 0.018 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.037 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.031 0.014 -9999.0 0.0 0.0 90.0 90.0 skeletal system development 0.029 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.037 0.021 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.035 0.008 -9999.0 0.0 0.0 24.0 24.0 PI3K 0.014 0.072 -9999.0 0.0 -0.198 46.0 46.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.031 0.014 -9999.0 0.0 0.0 88.0 88.0 somite specification 0.037 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.027 0.015 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.015 0.007 0.06 2.0 -9999.0 0.0 2.0 catabolic process 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.038 0.043 0.192 36.0 -9999.0 0.0 36.0 SHH Np/Cholesterol/Hhip -0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.032 0.013 -9999.0 0.0 0.0 76.0 76.0 receptor-mediated endocytosis 0.037 0.039 0.174 32.0 -9999.0 0.0 32.0 SHH Np/Cholesterol/BOC -0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.037 0.047 0.195 41.0 -9999.0 0.0 41.0 IHH N/PTCH2 0.058 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 IHH N/PTCH1 0.046 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.035 0.047 -9999.0 0.0 -0.188 17.0 17.0 PTCH2 0.036 0.006 -9999.0 0.0 0.0 16.0 16.0 SHH Np/Cholesterol 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0