Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.062 -9999.0 0.0 -0.199 39.0 39.0 epithelial cell differentiation 0.052 0.066 -9999.0 0.0 -0.16 37.0 37.0 CYFIP2 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 ENAH -0.037 0.08 0.202 10.0 -0.228 28.0 38.0 EGFR 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 EPHA2 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 MYO6 -0.026 0.054 0.181 8.0 -0.261 14.0 22.0 CTNNB1 0.035 0.007 -9999.0 0.0 0.0 22.0 22.0 ABI1/Sra1/Nap1 0.054 0.059 -9999.0 0.0 -0.164 31.0 31.0 AQP5 -0.013 0.044 -9999.0 0.0 -0.239 7.0 7.0 CTNND1 0.036 0.007 -9999.0 0.0 0.0 20.0 20.0 mol:PI-4-5-P2 -0.024 0.046 0.177 9.0 -0.249 6.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.045 0.177 7.0 -0.246 6.0 13.0 EGF 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 NCKAP1 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 AQP3 -0.014 0.045 0.174 1.0 -0.245 8.0 9.0 cortical microtubule organization 0.052 0.066 -9999.0 0.0 -0.16 37.0 37.0 GO:0000145 -0.024 0.043 0.159 9.0 -0.238 6.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.058 0.069 -9999.0 0.0 -0.161 37.0 37.0 MLLT4 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 ARF6/GDP -0.048 0.056 -9999.0 0.0 -0.173 64.0 64.0 ARF6 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 Ephrin A1/EPHA2/NCK1/GIT1 0.054 0.079 -9999.0 0.0 -0.165 48.0 48.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.024 0.073 0.171 5.0 -0.265 32.0 37.0 PVRL2 0.033 0.011 -9999.0 0.0 0.0 56.0 56.0 ZYX -0.024 0.049 0.179 8.0 -0.261 9.0 17.0 ARF6/GTP 0.061 0.083 -9999.0 0.0 -0.165 47.0 47.0 CDH1 0.032 0.012 -9999.0 0.0 0.0 66.0 66.0 EGFR/EGFR/EGF/EGF 0.045 0.064 -9999.0 0.0 -0.156 36.0 36.0 RhoA/GDP 0.041 0.085 -9999.0 0.0 -0.163 64.0 64.0 actin cytoskeleton organization -0.034 0.057 0.162 8.0 -0.267 14.0 22.0 IGF-1R heterotetramer 0.029 0.015 -9999.0 0.0 0.0 116.0 116.0 GIT1 0.035 0.008 -9999.0 0.0 0.0 23.0 23.0 IGF1R 0.029 0.015 -9999.0 0.0 0.0 116.0 116.0 IGF1 0.025 0.017 -9999.0 0.0 0.0 164.0 164.0 DIAPH1 0.02 0.178 -9999.0 0.0 -0.586 34.0 34.0 Wnt receptor signaling pathway -0.052 0.066 0.16 37.0 -9999.0 0.0 37.0 RHOA 0.034 0.01 -9999.0 0.0 0.0 43.0 43.0 RhoA/GTP -0.053 0.065 -9999.0 0.0 -0.183 78.0 78.0 CTNNA1 0.036 0.007 -9999.0 0.0 0.0 19.0 19.0 VCL -0.035 0.058 0.164 8.0 -0.273 14.0 22.0 EFNA1 0.032 0.013 -9999.0 0.0 0.0 69.0 69.0 LPP -0.031 0.051 0.166 6.0 -0.273 8.0 14.0 Ephrin A1/EPHA2 0.029 0.08 -9999.0 0.0 -0.162 64.0 64.0 SEC6/SEC8 -0.034 0.043 -9999.0 0.0 -0.173 35.0 35.0 MGAT3 -0.025 0.046 0.179 7.0 -0.249 6.0 13.0 HGF/MET 0.045 0.06 -9999.0 0.0 -0.164 27.0 27.0 HGF 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.062 -9999.0 0.0 -0.2 39.0 39.0 actin cable formation -0.007 0.106 0.264 16.0 -0.29 23.0 39.0 KIAA1543 -0.023 0.042 0.154 8.0 -0.236 6.0 14.0 KIFC3 -0.027 0.048 0.18 9.0 -0.252 6.0 15.0 NCK1 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 EXOC3 0.033 0.011 -9999.0 0.0 0.0 49.0 49.0 ACTN1 -0.026 0.056 0.181 10.0 -0.286 10.0 20.0 NCK1/GIT1 0.041 0.044 -9999.0 0.0 -0.193 15.0 15.0 mol:GDP 0.052 0.066 -9999.0 0.0 -0.16 37.0 37.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.027 0.037 -9999.0 0.0 -0.152 37.0 37.0 PIP5K1C -0.024 0.047 0.179 9.0 -0.252 6.0 15.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 ROCK1 -0.031 0.091 0.236 12.0 -0.258 23.0 35.0 adherens junction assembly -0.039 0.109 0.176 1.0 -0.425 23.0 24.0 IGF-1R heterotetramer/IGF1 -0.007 0.104 -9999.0 0.0 -0.163 130.0 130.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.044 -9999.0 0.0 -0.19 15.0 15.0 MET 0.034 0.01 -9999.0 0.0 0.0 43.0 43.0 PLEKHA7 -0.027 0.037 -9999.0 0.0 -0.152 37.0 37.0 mol:GTP 0.052 0.078 -9999.0 0.0 -0.164 48.0 48.0 establishment of epithelial cell apical/basal polarity -0.021 0.065 0.136 48.0 -0.251 10.0 58.0 cortical actin cytoskeleton stabilization 0.005 0.062 -9999.0 0.0 -0.199 39.0 39.0 regulation of cell-cell adhesion -0.034 0.057 0.162 8.0 -0.267 14.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.062 -9999.0 0.0 -0.2 39.0 39.0