E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.029 -9999.0 0.0 -0.27 1.0 1.0 KLHL20 0.002 0.04 0.125 1.0 -0.2 1.0 2.0 CYFIP2 -0.016 0.004 0.0 8.0 -9999.0 0.0 8.0 Rac1/GDP 0.006 0.062 0.158 12.0 -0.146 1.0 13.0 ENAH -0.005 0.028 -9999.0 0.0 -0.27 1.0 1.0 AP1M1 -0.016 0.003 0.0 4.0 -9999.0 0.0 4.0 RAP1B -0.015 0.005 0.0 13.0 -9999.0 0.0 13.0 RAP1A -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 CTNNB1 -0.016 0.005 0.0 11.0 -9999.0 0.0 11.0 CDC42/GTP -0.025 0.023 0.053 3.0 -0.091 1.0 4.0 ABI1/Sra1/Nap1 -0.014 0.016 -9999.0 0.0 -0.107 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.015 -9999.0 0.0 0.0 20.0 20.0 RAPGEF1 0.002 0.06 0.157 12.0 -0.209 2.0 14.0 CTNND1 -0.017 0.001 0.0 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.004 0.036 -9999.0 0.0 -0.287 2.0 2.0 CRK -0.009 0.032 -9999.0 0.0 -0.217 2.0 2.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.012 -9999.0 0.0 0.0 22.0 22.0 alphaE/beta7 Integrin 0.023 0.006 -9999.0 0.0 0.0 8.0 8.0 IQGAP1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 NCKAP1 -0.017 0.002 0.0 3.0 -9999.0 0.0 3.0 Rap1/GTP/I-afadin 0.027 0.012 -9999.0 0.0 0.0 23.0 23.0 DLG1 -0.008 0.038 -9999.0 0.0 -0.285 2.0 2.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.024 0.018 -9999.0 0.0 -0.076 1.0 1.0 MLLT4 -0.016 0.005 0.0 11.0 -9999.0 0.0 11.0 ARF6/GTP/NME1/Tiam1 0.029 0.01 -9999.0 0.0 0.0 14.0 14.0 PI3K -0.03 0.022 -9999.0 0.0 -0.094 1.0 1.0 ARF6 -0.016 0.003 0.0 6.0 -9999.0 0.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.008 -9999.0 0.0 0.0 16.0 16.0 TIAM1 -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 E-cadherin(dimer)/Ca2+ 0.033 0.014 -9999.0 0.0 0.0 21.0 21.0 AKT1 -0.012 0.033 0.06 11.0 -9999.0 0.0 11.0 PIK3R1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 CDH1 -0.017 0.002 0.0 3.0 -9999.0 0.0 3.0 RhoA/GDP 0.007 0.065 0.17 12.0 -9999.0 0.0 12.0 actin cytoskeleton organization 0.003 0.034 0.12 2.0 -0.147 1.0 3.0 CDC42/GDP 0.008 0.065 0.167 13.0 -0.146 1.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 -0.017 0.001 0.0 1.0 -9999.0 0.0 1.0 RAC1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.036 0.015 -9999.0 0.0 0.0 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.025 0.011 -9999.0 0.0 0.0 21.0 21.0 mol:GDP 0.008 0.068 0.172 13.0 -0.159 1.0 14.0 CDC42/GTP/IQGAP1 0.02 0.007 -9999.0 0.0 0.0 17.0 17.0 JUP -0.015 0.005 0.0 13.0 -9999.0 0.0 13.0 p120 catenin/RhoA/GDP 0.004 0.063 0.158 13.0 -9999.0 0.0 13.0 RAC1/GTP/IQGAP1 0.02 0.007 -9999.0 0.0 0.0 17.0 17.0 PIP5K1C/AP1M1 0.023 0.005 -9999.0 0.0 0.0 7.0 7.0 RHOA -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 CDC42 -0.016 0.005 0.0 11.0 -9999.0 0.0 11.0 CTNNA1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 positive regulation of S phase of mitotic cell cycle 0.004 0.032 0.146 3.0 -0.096 1.0 4.0 NME1 -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.008 0.039 -9999.0 0.0 -0.285 2.0 2.0 regulation of cell-cell adhesion -0.023 0.019 0.038 2.0 -0.082 1.0 3.0 WASF2 -0.004 0.018 0.046 2.0 -0.08 1.0 3.0 Rap1/GTP -0.015 0.046 0.117 12.0 -9999.0 0.0 12.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.002 0.027 0.102 2.0 -0.116 1.0 3.0 VAV2 0.016 0.078 0.257 2.0 -0.409 2.0 4.0 RAP1/GDP -0.004 0.054 0.148 10.0 -9999.0 0.0 10.0 adherens junction assembly -0.008 0.038 -9999.0 0.0 -0.278 2.0 2.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.016 0.003 0.0 6.0 -9999.0 0.0 6.0 PIP5K1C -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 regulation of heterotypic cell-cell adhesion -0.015 0.052 0.154 11.0 -9999.0 0.0 11.0 E-cadherin/beta catenin -0.008 0.009 0.011 1.0 -0.045 6.0 7.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.028 -9999.0 0.0 -0.27 1.0 1.0 PIK3CA -0.016 0.004 0.0 10.0 -9999.0 0.0 10.0 Rac1/GTP -0.017 0.032 -9999.0 0.0 -0.31 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.029 0.012 -9999.0 0.0 0.0 21.0 21.0 ITGAE -0.016 0.004 0.0 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.037 -9999.0 0.0 -0.292 2.0 2.0