Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.004 0.002 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.03 0.013 -9999.0 0.0 0.0 21.0 21.0 CYFIP2 -0.016 0.004 0.0 8.0 -9999.0 0.0 8.0 ENAH -0.021 0.059 0.194 4.0 -9999.0 0.0 4.0 EGFR -0.016 0.004 0.0 10.0 -9999.0 0.0 10.0 EPHA2 -0.016 0.004 0.0 7.0 -9999.0 0.0 7.0 MYO6 -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 CTNNB1 -0.016 0.005 0.0 11.0 -9999.0 0.0 11.0 ABI1/Sra1/Nap1 0.03 0.011 -9999.0 0.0 0.0 15.0 15.0 AQP5 -0.009 0.043 0.14 10.0 -9999.0 0.0 10.0 CTNND1 -0.017 0.001 0.0 1.0 -9999.0 0.0 1.0 mol:PI-4-5-P2 -0.013 0.051 0.156 11.0 -9999.0 0.0 11.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.051 0.156 11.0 -9999.0 0.0 11.0 EGF -0.016 0.003 0.0 4.0 -9999.0 0.0 4.0 NCKAP1 -0.017 0.002 0.0 3.0 -9999.0 0.0 3.0 AQP3 -0.012 0.047 0.14 9.0 -0.288 1.0 10.0 cortical microtubule organization 0.03 0.013 -9999.0 0.0 0.0 21.0 21.0 GO:0000145 -0.012 0.048 0.146 11.0 -9999.0 0.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.014 -9999.0 0.0 0.0 21.0 21.0 MLLT4 -0.016 0.005 0.0 11.0 -9999.0 0.0 11.0 ARF6/GDP -0.037 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 -0.016 0.003 0.0 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2/NCK1/GIT1 0.037 0.015 -9999.0 0.0 0.0 20.0 20.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.043 0.147 8.0 -0.169 1.0 9.0 PVRL2 -0.016 0.004 0.0 10.0 -9999.0 0.0 10.0 ZYX -0.013 0.049 0.157 10.0 -9999.0 0.0 10.0 ARF6/GTP 0.039 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.017 0.002 0.0 3.0 -9999.0 0.0 3.0 EGFR/EGFR/EGF/EGF -0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.015 0.048 0.143 11.0 -9999.0 0.0 11.0 IGF-1R heterotetramer -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 GIT1 -0.016 0.003 0.0 4.0 -9999.0 0.0 4.0 IGF1R -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 IGF1 -0.016 0.003 0.0 4.0 -9999.0 0.0 4.0 DIAPH1 -0.016 0.145 -9999.0 0.0 -0.474 12.0 12.0 Wnt receptor signaling pathway -0.03 0.013 0.0 21.0 -9999.0 0.0 21.0 RHOA -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 RhoA/GTP -0.038 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 VCL -0.015 0.048 0.144 11.0 -9999.0 0.0 11.0 EFNA1 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 LPP -0.017 0.048 0.147 10.0 -9999.0 0.0 10.0 Ephrin A1/EPHA2 -0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.034 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 HGF/MET -0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.016 0.003 0.0 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.004 0.002 -9999.0 0.0 0.0 21.0 21.0 actin cable formation -0.003 0.076 0.19 9.0 -0.193 4.0 13.0 KIAA1543 -0.018 0.05 0.147 11.0 -9999.0 0.0 11.0 KIFC3 -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 NCK1 -0.017 0.002 0.0 2.0 -9999.0 0.0 2.0 EXOC3 -0.016 0.004 0.0 9.0 -9999.0 0.0 9.0 ACTN1 -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 NCK1/GIT1 0.024 0.005 -9999.0 0.0 0.0 6.0 6.0 mol:GDP 0.03 0.013 -9999.0 0.0 0.0 21.0 21.0 EXOC4 -0.016 0.004 0.0 7.0 -9999.0 0.0 7.0 STX4 -0.021 0.009 0.0 21.0 -9999.0 0.0 21.0 PIP5K1C -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.016 0.003 0.0 6.0 -9999.0 0.0 6.0 ROCK1 -0.017 0.068 0.213 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.028 0.097 0.145 3.0 -0.342 7.0 10.0 IGF-1R heterotetramer/IGF1 -0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.021 0.008 -9999.0 0.0 0.0 18.0 18.0 MET -0.015 0.005 0.0 12.0 -9999.0 0.0 12.0 PLEKHA7 -0.013 0.051 0.157 11.0 -9999.0 0.0 11.0 mol:GTP 0.035 0.015 -9999.0 0.0 0.0 20.0 20.0 establishment of epithelial cell apical/basal polarity -0.022 0.051 0.134 11.0 -9999.0 0.0 11.0 cortical actin cytoskeleton stabilization 0.004 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.015 0.048 0.143 11.0 -9999.0 0.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.004 0.002 -9999.0 0.0 0.0 21.0 21.0