rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY7(6), ADCY8(16), ADCY9(25), ADORA2A(5), ADORA2B(2), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), ATP2A1(16), ATP2A2(9), ATP2A3(12), ATP2B1(17), ATP2B2(12), ATP2B3(21), ATP2B4(18), AVPR1A(8), AVPR1B(3), BDKRB1(5), BDKRB2(9), BST1(5), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1F(36), CACNA1G(20), CACNA1I(13), CACNA1S(33), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CCKAR(12), CCKBR(7), CD38(7), CHRM1(6), CHRM2(9), CHRM3(9), CHRM5(13), CHRNA7(6), CYSLTR1(5), CYSLTR2(6), DRD1(6), EDNRA(6), EDNRB(2), EGFR(20), ERBB2(6), ERBB3(16), ERBB4(29), F2R(8), GNA11(3), GNA14(5), GNA15(1), GNAL(6), GNAS(25), GRIN1(5), GRIN2A(25), GRIN2C(6), GRIN2D(8), GRM1(22), GRM5(22), GRPR(4), HRH1(9), HRH2(3), HTR2A(15), HTR2B(2), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), LHCGR(16), LTB4R2(3), MYLK(17), MYLK2(7), NOS1(21), NOS3(11), NTSR1(4), OXTR(4), P2RX1(9), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(3), PDE1A(12), PDE1B(9), PDE1C(14), PDGFRA(29), PDGFRB(12), PHKA1(17), PHKA2(15), PHKB(14), PHKG1(6), PHKG2(3), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PLN(1), PPID(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PTAFR(6), PTGER3(9), PTGFR(10), PTK2B(16), RYR1(80), RYR2(111), RYR3(87), SLC25A4(3), SLC25A5(4), SLC25A6(6), SLC8A1(20), SLC8A2(6), SLC8A3(14), SPHK1(2), SPHK2(1), TACR1(6), TACR2(4), TACR3(9), TNNC1(2), TNNC2(4), TRHR(5), TRPC1(15), VDAC1(2), VDAC3(4)	91603920	1888	150	1836	659	546	777	260	92	190	23	3.22e-15	1.98e-12
2	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	133	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), ANXA6(10), ARRB1(7), ARRB2(3), ATP1A4(24), ATP1B1(3), ATP1B2(7), ATP1B3(4), ATP2A2(9), ATP2A3(12), ATP2B1(17), ATP2B2(12), ATP2B3(21), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1S(33), CACNB1(9), CACNB3(6), CALM2(3), CALM3(1), CALR(4), CAMK1(9), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CASQ1(7), CASQ2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), GJA1(6), GJA4(2), GJB1(1), GJB2(3), GJB3(2), GJB4(5), GJB5(3), GJB6(4), GNA11(3), GNAI2(7), GNAI3(3), GNAO1(5), GNAZ(7), GNB1(3), GNB2(5), GNB3(4), GNB4(3), GNB5(3), GNG12(2), GNG13(2), GNG2(2), GNG3(3), GRK4(14), GRK5(10), GRK6(3), ITPR1(31), ITPR2(38), ITPR3(23), KCNB1(17), KCNJ3(15), KCNJ5(6), MIB1(8), MYCBP(1), NME7(4), PEA15(2), PKIG(2), PLCB3(9), PLN(1), PRKACA(4), PRKACB(2), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), RGS1(6), RGS10(3), RGS14(5), RGS16(3), RGS17(5), RGS18(2), RGS2(3), RGS20(5), RGS3(15), RGS4(6), RGS5(4), RGS6(7), RGS7(9), RGS9(19), RYR1(80), RYR2(111), RYR3(87), SLC8A1(20), SLC8A3(14), USP5(13), YWHAB(1), YWHAH(4), YWHAQ(3)	65550530	1346	138	1309	463	395	564	151	72	145	19	3.36e-11	1.04e-08
3	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	214	ADCYAP1R1(7), ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), ADRA1A(11), ADRA1B(7), ADRA2B(5), ADRB1(2), ADRB2(8), AGTR2(8), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), C5AR1(5), CALCR(5), CALCRL(9), CCKAR(12), CCKBR(7), CGA(1), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CNR1(8), CNR2(3), CRHR1(2), CRHR2(2), CTSG(3), CYSLTR1(5), CYSLTR2(6), DRD1(6), DRD2(10), DRD3(5), DRD5(11), EDNRA(6), EDNRB(2), F2(9), F2R(8), F2RL1(3), F2RL2(3), FPR1(4), FSHR(17), GABBR1(17), GABBR2(14), GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), GABRB1(8), GABRB2(16), GABRB3(15), GABRE(7), GABRG1(8), GABRG2(19), GABRG3(14), GABRP(5), GABRQ(7), GABRR1(5), GABRR2(2), GALR1(2), GALR3(3), GH1(6), GH2(5), GHR(10), GHRHR(2), GHSR(7), GIPR(4), GLP1R(8), GLP2R(17), GLRA1(9), GLRA2(6), GLRA3(11), GLRB(8), GNRHR(4), GPR156(6), GPR50(8), GPR63(5), GPR83(5), GRIA1(12), GRIA2(25), GRIA4(23), GRID1(16), GRID2(13), GRIK1(16), GRIK2(15), GRIK3(17), GRIK4(8), GRIK5(19), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), GRIN3A(15), GRM1(22), GRM2(7), GRM3(20), GRM4(16), GRM5(22), GRM7(15), GRM8(24), GRPR(4), GZMA(6), HCRTR1(1), HCRTR2(8), HRH1(9), HRH2(3), HRH4(4), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR2A(15), HTR2B(2), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), LEP(2), LEPR(15), LHB(3), LHCGR(16), LTB4R(3), LTB4R2(3), MAS1(2), MC2R(2), MC3R(8), MC4R(7), MC5R(12), MCHR1(7), MCHR2(1), MLNR(3), MTNR1A(6), MTNR1B(4), NMBR(4), NMUR1(8), NMUR2(7), NPBWR1(2), NPFFR1(2), NPFFR2(12), NPY1R(6), NPY2R(4), NPY5R(10), NR3C1(13), NTSR1(4), NTSR2(2), OPRD1(2), OPRK1(9), OPRM1(11), OXTR(4), P2RX1(9), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(3), P2RY1(2), P2RY10(6), P2RY11(7), P2RY13(3), P2RY14(5), P2RY2(6), P2RY4(7), P2RY6(3), PARD3(27), PPYR1(7), PRL(6), PRLHR(2), PRLR(6), PRSS1(7), PRSS3(2), PTAFR(6), PTGDR(6), PTGER2(5), PTGER3(9), PTGER4(8), PTGFR(10), PTGIR(3), PTH2R(7), RXFP1(16), RXFP2(17), SCTR(4), SSTR2(3), SSTR3(6), TAAR1(6), TAAR2(5), TAAR5(8), TAAR6(5), TAAR8(3), TAAR9(8), TACR1(6), TACR2(4), TACR3(9), THRA(5), THRB(4), TRHR(5), TRPV1(6), TSHB(3), TSHR(12), VIPR1(3)	71058285	1639	145	1582	539	480	673	258	73	153	2	4.29e-10	8.81e-08
4	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	225	ACVR1B(6), ACVR1C(7), AKT1(8), AKT2(4), AKT3(8), ARRB1(7), ARRB2(3), ATF2(6), ATF4(4), BDNF(8), BRAF(12), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1F(36), CACNA1G(20), CACNA1I(13), CACNA1S(33), CACNA2D1(14), CACNA2D2(9), CACNA2D3(20), CACNA2D4(18), CACNB1(9), CACNB2(11), CACNB3(6), CACNB4(14), CACNG2(3), CACNG3(9), CACNG4(6), CACNG5(4), CACNG6(6), CACNG7(10), CASP3(4), CD14(2), CDC25B(3), CDC42(5), CHUK(11), CRK(1), CRKL(5), DAXX(11), DDIT3(1), DUSP1(2), DUSP10(7), DUSP14(3), DUSP16(13), DUSP2(4), DUSP3(2), DUSP4(1), DUSP5(5), DUSP6(1), DUSP7(4), DUSP9(8), ECSIT(5), EGF(24), EGFR(20), ELK1(2), ELK4(3), FAS(7), FASLG(6), FGF1(1), FGF10(1), FGF11(2), FGF12(4), FGF13(6), FGF14(3), FGF16(1), FGF17(1), FGF18(2), FGF21(3), FGF23(6), FGF5(8), FGF6(2), FGF7(6), FGF8(2), FGF9(2), FGFR1(10), FGFR4(11), FLNA(31), FLNB(38), FLNC(34), FOS(6), GNA12(10), GNG12(2), GRB2(3), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K5(2), MAP2K6(9), MAP3K10(7), MAP3K12(8), MAP3K13(13), MAP3K14(12), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K6(7), MAP3K7(8), MAP3K8(12), MAP4K1(13), MAP4K2(6), MAP4K3(21), MAP4K4(14), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK7(17), MAPK8(7), MAPK8IP1(5), MAPK9(7), MAPKAPK2(6), MAPKAPK3(4), MAPKAPK5(6), MAPT(11), MAX(8), MEF2C(11), MKNK1(6), MKNK2(4), MOS(8), MRAS(3), MYC(7), NF1(40), NFATC2(15), NFATC4(8), NFKB1(12), NFKB2(10), NLK(5), NR4A1(4), NTF3(6), NTRK1(11), NTRK2(15), PAK1(3), PAK2(6), PDGFB(4), PDGFRA(29), PDGFRB(12), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PPM1A(7), PPM1B(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PPP5C(7), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PTPN5(5), PTPN7(5), PTPRR(18), RAC2(2), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF2(38), RASA2(8), RASGRF1(13), RASGRF2(17), RASGRP1(8), RASGRP2(5), RASGRP3(8), RASGRP4(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KA5(7), RPS6KA6(15), RRAS(1), RRAS2(5), SOS1(21), SOS2(22), SRF(3), STK3(9), STK4(6), STMN1(6), TAOK1(10), TAOK2(10), TAOK3(4), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TNF(1), TNFRSF1A(6), TRAF2(5), TRAF6(4), ZAK(12)	92476270	1836	141	1785	566	501	733	230	111	239	22	1.14e-08	1.75e-06
5	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	121	ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), AKT1(8), AKT2(4), AKT3(8), AMOTL1(14), ASH1L(40), CASK(20), CDC42(5), CDK4(4), CGN(15), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CRB3(1), CSDA(6), CSNK2A1(9), CSNK2A2(5), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTTN(8), EPB41(11), EPB41L1(11), EPB41L2(13), EPB41L3(18), EXOC3(12), EXOC4(4), F11R(2), GNAI1(4), GNAI2(7), GNAI3(3), HCLS1(8), IGSF5(9), INADL(17), JAM2(9), JAM3(3), LLGL1(14), LLGL2(5), MAGI1(32), MAGI2(26), MAGI3(17), MLLT4(32), MPDZ(22), MPP5(5), MRAS(3), MYH1(44), MYH10(29), MYH11(39), MYH13(27), MYH14(22), MYH15(22), MYH2(37), MYH3(30), MYH4(36), MYH6(23), MYH7(28), MYH7B(15), MYH8(35), MYH9(26), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLPF(2), OCLN(5), PARD3(27), PARD6A(1), PARD6B(3), PPM1J(3), PPP2CA(6), PPP2CB(2), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PPP2R3A(13), PPP2R4(7), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), RAB13(3), RAB3B(1), RHOA(4), RRAS(1), RRAS2(5), SPTAN1(29), SRC(2), SYMPK(20), TJAP1(8), TJP1(33), TJP2(16), TJP3(6), VAPA(5), YES1(5), ZAK(12)	64754182	1330	139	1292	409	366	531	194	61	161	17	3.56e-08	4.38e-06
6	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	118	ACACA(27), ACACB(31), AKT1(8), AKT2(4), AKT3(8), ARAF(8), BAD(2), BRAF(12), CALM2(3), CALM3(1), CALML6(4), CBL(10), CBLB(15), CBLC(5), CRK(1), CRKL(5), ELK1(2), EXOC7(8), FBP1(4), FLOT1(1), FLOT2(3), FOXO1(11), G6PC(6), G6PC2(9), GCK(5), GRB2(3), GSK3B(11), GYS1(12), GYS2(19), IKBKB(15), INPP5D(14), INSR(18), IRS1(17), IRS4(20), LIPE(7), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MKNK1(6), MKNK2(4), PCK1(15), PCK2(7), PDE3A(17), PDE3B(15), PDPK1(3), PFKM(7), PFKP(11), PHKA1(17), PHKA2(15), PHKB(14), PHKG1(6), PHKG2(3), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PKLR(10), PKM2(5), PPARGC1A(13), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R3A(23), PPP1R3B(3), PPP1R3C(3), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKACA(4), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(4), PTPN1(4), PTPRF(34), PYGB(10), PYGL(9), PYGM(10), RAF1(7), RAPGEF1(18), RHEB(2), RHOQ(1), RPS6(6), RPS6KB1(3), RPS6KB2(6), SH2B2(2), SHC1(11), SHC3(9), SHC4(7), SLC2A4(4), SOCS2(7), SOCS4(4), SORBS1(22), SOS1(21), SOS2(22), SREBF1(6), TRIP10(6), TSC1(13), TSC2(14)	49120714	981	128	952	281	250	412	126	43	138	12	4.85e-06	0.00050
7	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(8), CREB1(5), GRB2(3), MAPK1(2), MAPK3(4), MAPK7(17), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), NTRK1(11), PLCG1(12), RPS6KA1(5), SHC1(11)	5187495	104	52	96	30	23	51	9	5	16	0	6.65e-06	0.00058
8	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	17	AXIN1(8), BTRC(13), CREBBP(37), CSNK1A1(5), CSNK2A1(9), FZD1(2), GSK3B(11), HDAC1(4), MAP3K7(8), MYC(7), NLK(5), PPARD(6), PPP2CA(6), TLE1(12), WIF1(5), WNT1(1)	6567242	139	59	136	28	43	56	17	3	18	2	0.000018	0.0014
9	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	10	AXIN1(8), CREBBP(37), EP300(29), FZD1(2), GSK3B(11), HDAC1(4), LDB1(3), LEF1(9), TRRAP(72), WNT1(1)	8072942	176	62	170	33	49	68	23	6	28	2	0.000028	0.0019
10	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	CDH1(15), CREBBP(37), EP300(29), MAP2K1(2), MAP3K7(8), MAPK3(4), SKIL(13), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6)	6902081	141	57	136	37	35	58	20	6	22	0	0.000054	0.0032
11	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(8), DPM2(4), GRB2(3), KLK2(2), NTRK1(11), PLCG1(12), PRKCA(10), SHC1(11), SOS1(21)	4122511	82	45	75	25	22	37	8	5	8	2	0.000057	0.0032
12	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(8), AKT2(4), AKT3(8), BPNT1(1), GRB2(3), ILK(8), MAPK1(2), MAPK3(4), PDK1(7), PIK3CD(10), PTK2B(16), RBL2(21), SHC1(11), SOS1(21)	5893501	124	53	111	29	32	50	14	7	16	5	0.000077	0.0040
13	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(8), BAD(2), GRB2(3), IGF1R(13), IRS1(17), MAP2K1(2), MAPK1(2), MAPK3(4), RAF1(7), SHC1(11), SOS1(21), YWHAH(4)	5263975	94	47	89	25	20	43	13	6	10	2	0.00025	0.011
14	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	179	ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), AKT1(8), AKT2(4), AKT3(8), ARHGAP5(24), BAD(2), BIRC2(13), BIRC3(3), BRAF(12), CAPN2(6), CAV2(1), CCND2(7), CCND3(5), CDC42(5), CHAD(3), COL11A1(36), COL11A2(13), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), COMP(7), CRK(1), CRKL(5), DIAPH1(11), DOCK1(32), EGF(24), EGFR(20), ELK1(2), ERBB2(6), FARP2(18), FIGF(5), FLNA(31), FLNB(38), FLNC(34), FLT1(23), FN1(39), FYN(7), GRB2(3), GSK3B(11), HGF(15), IBSP(6), IGF1(3), IGF1R(13), ILK(8), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAV(10), ITGB1(12), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), JUN(1), KDR(23), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MET(10), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLK(17), MYLK2(7), MYLPF(2), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PARVA(2), PARVB(2), PARVG(3), PDGFB(4), PDGFC(4), PDGFD(6), PDGFRA(29), PDGFRB(12), PDPK1(3), PGF(2), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP5K1C(5), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PRKCA(10), PRKCG(10), PTK2(11), PXN(6), RAC2(2), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF1(18), RELN(48), RHOA(4), ROCK1(27), ROCK2(15), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SPP1(3), SRC(2), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TLN1(28), TLN2(29), TNC(19), TNN(16), TNR(16), TNXB(25), VASP(2), VAV1(16), VAV2(5), VAV3(13), VCL(14), VEGFA(1), VEGFB(2), VEGFC(7), VWF(31), ZYX(12)	120892653	2223	142	2168	695	571	918	292	104	293	45	0.00025	0.011
15	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	22	AKT1(8), AKT2(4), AKT3(8), BAD(2), GRB2(3), GSK3A(9), GSK3B(11), IL4R(6), IRS1(17), JAK3(9), MAP4K1(13), MAPK1(2), MAPK3(4), PDK1(7), PIK3CD(10), PPP1R13B(7), RAF1(7), SHC1(11), SOS1(21), SOS2(22), STAT6(10)	10020314	191	67	182	42	43	84	28	8	24	4	0.00027	0.011
16	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	185	ABI2(4), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), ARAF(8), ARHGEF1(11), ARHGEF12(25), ARHGEF4(5), ARHGEF6(19), ARHGEF7(13), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), ARPC5(1), BAIAP2(1), BDKRB1(5), BDKRB2(9), BRAF(12), CD14(2), CDC42(5), CFL1(1), CFL2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CRK(1), CRKL(5), CSK(1), CYFIP1(13), CYFIP2(20), DIAPH1(11), DIAPH2(22), DIAPH3(26), DOCK1(32), EGF(24), EGFR(20), EZR(6), F2(9), F2R(8), FGD1(12), FGD3(12), FGF1(1), FGF10(1), FGF11(2), FGF12(4), FGF13(6), FGF14(3), FGF16(1), FGF17(1), FGF18(2), FGF21(3), FGF23(6), FGF5(8), FGF6(2), FGF7(6), FGF8(2), FGF9(2), FGFR1(10), FGFR4(11), FN1(39), GIT1(9), GNA12(10), GNA13(9), GNG12(2), GSN(5), IQGAP1(12), IQGAP2(26), IQGAP3(18), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAD(11), ITGAE(14), ITGAL(13), ITGAM(24), ITGAV(10), ITGAX(9), ITGB1(12), ITGB2(14), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), LIMK1(7), MAP2K1(2), MAPK1(2), MAPK3(4), MOS(8), MRAS(3), MSN(15), MYH10(29), MYH14(22), MYH9(26), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLK(17), MYLK2(7), MYLPF(2), NCKAP1(10), NCKAP1L(18), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDGFB(4), PDGFRA(29), PDGFRB(12), PFN1(1), PFN2(3), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PPP1R12B(18), PTK2(11), PXN(6), RAC2(2), RAF1(7), RDX(12), RHOA(4), ROCK1(27), ROCK2(15), RRAS(1), RRAS2(5), SCIN(3), SLC9A1(10), SOS1(21), SOS2(22), SSH1(13), SSH2(15), SSH3(3), TIAM1(26), TIAM2(21), TMSL3(1), VAV1(16), VAV2(5), VAV3(13), VCL(14), WASF1(3), WASF2(5), WASL(8)	87794021	1690	133	1651	553	456	694	217	80	223	20	0.00061	0.021
17	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(6), CDC42(5), CREB1(5), DAXX(11), DDIT3(1), ELK1(2), GRB2(3), HMGN1(1), HSPB2(1), MAP2K4(6), MAP2K6(9), MAP3K5(21), MAP3K7(8), MAP3K9(6), MAPK14(6), MAPKAPK2(6), MAPKAPK5(6), MAX(8), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MKNK1(6), MYC(7), PLA2G4A(11), RIPK1(8), RPS6KA5(7), SHC1(11), STAT1(14), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TRAF2(5)	11710044	233	68	228	65	58	107	28	11	29	0	0.00064	0.021
18	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(8), ATF1(6), CDC42(5), CREB1(5), CREB3(2), CREB5(6), DUSP1(2), DUSP10(7), EEF2K(11), EIF4E(4), ELK1(2), IL1R1(5), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K10(7), MAP3K4(23), MAP3K5(21), MAP3K7(8), MAPK1(2), MAPK13(2), MAPK14(6), MAPKAPK2(6), MAPKAPK5(6), MKNK1(6), MKNK2(4), MYEF2(6), NFKB1(12), NR2C2(8), SRF(3), TRAF6(4)	11095097	210	64	203	61	49	100	30	9	22	0	0.00065	0.021
19	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	92	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CREB1(5), CREB3(2), CREB3L1(6), CREB3L2(8), CREB3L3(9), CREB3L4(8), CREBBP(37), DCT(15), DVL2(12), DVL3(7), EDN1(2), EDNRB(2), EP300(29), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD4(4), FZD6(15), FZD7(5), FZD9(7), GNAI1(4), GNAI2(7), GNAI3(3), GNAO1(5), GNAS(25), GSK3B(11), KIT(28), KITLG(2), LEF1(9), MAP2K1(2), MAPK1(2), MAPK3(4), MITF(3), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), POMC(2), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), RAF1(7), TCF7(4), TCF7L1(5), TCF7L2(18), TYR(10), TYRP1(6), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1)	34086658	650	104	631	239	173	260	89	39	87	2	0.00068	0.021
20	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(19), CARM1(6), CREBBP(37), EP300(29), ERCC3(11), GRIP1(12), GTF2A1(5), GTF2E1(4), GTF2F1(6), HDAC1(4), HDAC2(5), HDAC3(10), HDAC4(18), HDAC5(15), HDAC6(22), MEF2C(11), NCOR2(24), NR0B1(8), NRIP1(18), PELP1(13), POLR2A(25), SRA1(3), TBP(5)	14668864	310	73	300	103	52	158	37	11	50	2	0.00069	0.021
21	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	132	ACTA1(4), ACTA2(7), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADM(2), ARRB1(7), ARRB2(3), ATF1(6), ATF2(6), ATF3(4), ATF4(4), ATP2A2(9), ATP2A3(12), CACNB3(6), CALCA(1), CALM2(3), CALM3(1), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CNN1(3), CORIN(11), CREB3(2), CRHR1(2), DGKZ(9), ETS2(5), FOS(6), GABPA(5), GABPB2(10), GBA2(13), GJA1(6), GNB1(3), GNB2(5), GNB3(4), GNB4(3), GNB5(3), GNG12(2), GNG13(2), GNG2(2), GNG3(3), GRK4(14), GRK5(10), GRK6(3), GSTO1(3), GUCA2A(1), GUCA2B(1), GUCY1A3(12), IGFBP1(5), IGFBP2(4), IGFBP3(7), IGFBP6(2), IL1B(2), IL6(2), ITPR1(31), ITPR2(38), ITPR3(23), JUN(1), MIB1(8), MYL2(1), MYL4(1), MYLK2(7), NFKB1(12), NOS1(21), NOS3(11), OXTR(4), PDE4B(17), PDE4D(7), PKIG(2), PLCB3(9), PLCD1(5), PLCG1(12), PLCG2(27), PRKACA(4), PRKACB(2), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(6), RGS10(3), RGS14(5), RGS16(3), RGS17(5), RGS18(2), RGS2(3), RGS20(5), RGS3(15), RGS4(6), RGS5(4), RGS6(7), RGS7(9), RGS9(19), RLN1(3), RYR1(80), RYR2(111), RYR3(87), SLC8A1(20), SP1(6), TNXB(25), USP5(13), YWHAB(1), YWHAH(4), YWHAQ(3)	59891010	1157	116	1126	402	343	473	146	56	122	17	0.00082	0.023
22	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	12	AKT1(8), CDKN1B(5), GRB2(3), ILK(8), ITGB1(12), MAPK1(2), MAPK3(4), PDK2(5), PDPK1(3), PTK2(11), SHC1(11), SOS1(21)	4707583	93	42	84	21	17	43	13	4	14	2	0.00082	0.023
23	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	17	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), INSR(18), IRS1(17), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PTPN11(8), RAF1(7), SHC1(11), SLC2A4(4), SOS1(21), SRF(3)	6694629	123	53	120	34	36	54	14	6	11	2	0.00089	0.024
24	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	130	AXIN1(8), AXIN2(1), BTRC(13), CACYBP(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CCND2(7), CCND3(5), CER1(2), CHD8(39), CREBBP(37), CSNK1A1(5), CSNK1A1L(4), CSNK1E(10), CSNK2A1(9), CSNK2A2(5), CTBP2(7), CTNNBIP1(2), CUL1(12), CXXC4(1), DAAM1(17), DAAM2(14), DKK1(4), DKK2(4), DKK4(3), DVL2(12), DVL3(7), EP300(29), FBXW11(5), FOSL1(4), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD4(4), FZD6(15), FZD7(5), FZD9(7), GSK3B(11), JUN(1), LEF1(9), LRP5(18), LRP6(18), MAP3K7(8), MAPK10(9), MAPK8(7), MAPK9(7), MMP7(3), MYC(7), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NKD1(4), NLK(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PORCN(12), PPARD(6), PPP2CA(6), PPP2CB(2), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRICKLE1(8), PRICKLE2(6), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PSEN1(4), RAC2(2), RBX1(1), RHOA(4), ROCK1(27), ROCK2(15), RUVBL1(2), SENP2(11), SFRP1(5), SFRP2(3), SFRP4(10), SFRP5(2), SIAH1(3), SKP1(2), SMAD2(12), SMAD3(4), SMAD4(5), TBL1X(7), TBL1XR1(15), TCF7(4), TCF7L1(5), TCF7L2(18), VANGL1(5), VANGL2(10), WIF1(5), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1)	49067417	924	114	903	287	253	365	127	40	127	12	0.00093	0.024
25	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(8), EIF4A1(4), EIF4A2(6), EIF4B(6), EIF4E(4), EIF4G1(15), EIF4G2(8), EIF4G3(26), MKNK1(6), PDK2(5), PDPK1(3), PPP2CA(6), RPS6(6), RPS6KB1(3), TSC1(13), TSC2(14)	7363829	133	56	129	33	27	64	13	9	20	0	0.0016	0.039
26	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(8), AKT2(4), AKT3(8), CDKN1A(1), ELK1(2), GRB2(3), MAP2K1(2), NGFR(4), NTRK1(11), PIK3CD(10), SHC1(11), SOS1(21)	4456155	85	42	79	23	23	39	9	5	7	2	0.0016	0.039
27	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	29	AKT1(8), BAD(2), BCL2L1(3), CBL(10), CFLAR(7), CRKL(5), FOS(6), GRB2(3), IL2RA(3), IL2RB(6), IL2RG(11), IRS1(17), JAK3(9), MAPK1(2), MAPK3(4), MYC(7), NMI(1), PPIA(2), RAF1(7), RPS6KB1(3), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5), SYK(6)	10038478	164	60	159	38	45	81	16	6	14	2	0.0017	0.039
28	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(8), GRB2(3), IL2RG(11), IL4R(6), IRS1(17), JAK3(9), RPS6KB1(3), SHC1(11), STAT6(10)	4375612	78	43	75	21	18	42	8	2	8	0	0.0019	0.040
29	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(8), AKT1(8), ANXA1(4), CALM2(3), CALM3(1), GNAS(25), GNB1(3), NFKB1(12), NOS3(11), NPPA(1), NR3C1(13), RELA(6), SYT1(4)	4530962	99	44	93	22	25	46	13	2	13	0	0.0019	0.040
30	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	ADAM17(11), APH1A(1), CREBBP(37), CTBP2(7), DLL1(8), DLL3(5), DLL4(2), DTX1(5), DTX2(4), DTX3(5), DTX3L(8), DTX4(7), DVL2(12), DVL3(7), EP300(29), HDAC1(4), HDAC2(5), HES1(1), JAG1(15), MAML1(8), MAML2(9), MAML3(16), MFNG(5), NCOR2(24), NCSTN(10), NOTCH2(17), NOTCH3(31), NOTCH4(15), NUMB(11), NUMBL(4), PSEN1(4), PSEN2(5), PTCRA(1), RBPJ(7), RBPJL(8), SNW1(5)	19803062	353	80	347	115	91	159	40	17	42	4	0.0021	0.043
31	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(11), CREBBP(37), EP300(29), FADD(1), HDAC3(10), IKBKB(15), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF6(4)	7582992	146	51	141	43	27	59	25	7	28	0	0.0022	0.043
32	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(18), AMY2A(7), AMY2B(11), ENPP1(11), ENPP3(16), G6PC(6), GAA(5), GANAB(13), GBA3(9), GBE1(12), GCK(5), GPI(9), GUSB(5), GYS1(12), GYS2(19), HK1(13), HK2(8), HK3(12), MGAM(49), PGM1(9), PGM3(6), PYGB(10), PYGL(9), PYGM(10), SI(47), UCHL1(5), UCHL3(1), UGDH(3), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10), UXS1(5)	19412775	415	80	403	96	118	151	64	26	56	0	0.0028	0.053
33	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	ABCB1(28), AKT1(8), BAX(4), CDKN1A(1), CPB2(7), CSNK1A1(5), FHL2(1), HIF1A(17), IGFBP3(7), MAPK8(7), MDM2(6), NFKBIB(3), NQO1(3)	4481489	97	42	91	30	28	34	12	6	15	2	0.0028	0.053
34	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(8), AKT2(4), AKT3(8), BCL2L1(3), CBL(10), CBLB(15), CBLC(5), CCND2(7), CCND3(5), CLCF1(2), CNTF(3), CNTFR(2), CREBBP(37), CSF2RA(9), CSF2RB(11), CSF3(1), CSF3R(11), EP300(29), EPO(2), EPOR(4), GH1(6), GH2(5), GHR(10), GRB2(3), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), IFNK(2), IFNW1(2), IL10(4), IL10RA(7), IL10RB(9), IL11RA(7), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL13RA1(14), IL13RA2(3), IL15(1), IL15RA(3), IL19(1), IL2(4), IL20(6), IL20RA(3), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(8), IL24(7), IL26(7), IL28A(2), IL28B(4), IL28RA(8), IL29(2), IL2RA(3), IL2RB(6), IL2RG(11), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL6ST(10), IL7(2), IL7R(9), IRF9(6), JAK2(21), JAK3(9), LEP(2), LEPR(15), LIF(3), LIFR(22), MPL(5), MYC(7), OSM(3), OSMR(12), PIAS1(5), PIAS2(12), PIAS3(9), PIAS4(4), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIM1(4), PRL(6), PRLR(6), PTPN11(8), SOCS2(7), SOCS4(4), SOCS5(12), SOCS7(4), SOS1(21), SOS2(22), SPRED1(8), SPRED2(7), SPRY1(4), SPRY2(6), SPRY4(2), STAM(7), STAM2(7), STAT1(14), STAT2(12), STAT3(12), STAT4(9), STAT5A(5), STAT5B(5), STAT6(10), TPO(18), TSLP(2), TYK2(7)	47675003	943	119	920	262	258	369	130	53	119	14	0.0033	0.058
35	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(40), ASH2L(11), C17orf79(4), CARM1(6), CTCFL(15), DOT1L(8), EED(6), EHMT2(6), EZH1(11), EZH2(14), FBXO11(8), HCFC1(27), HSF4(2), JMJD4(3), JMJD6(3), KDM6A(10), MEN1(5), MLL(38), MLL2(64), MLL3(71), MLL5(22), NSD1(36), OGT(19), PAXIP1(2), PPP1CA(6), PPP1CB(7), PPP1CC(2), PRDM2(23), PRDM9(28), PRMT1(7), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), RBBP5(9), SATB1(14), SETD1A(12), SETD2(31), SETD7(6), SETD8(3), SETDB1(19), SETDB2(12), SETMAR(6), SMYD3(4), STK38(7), SUV39H1(10), SUV39H2(6), SUV420H1(11), SUZ12(8), WHSC1(25), WHSC1L1(24)	39661572	741	106	717	173	174	280	108	32	126	21	0.0033	0.058
36	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACP1(4), ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), ACVR1B(6), ACVR1C(7), BAIAP2(1), CDC42(5), CDH1(15), CREBBP(37), CSNK2A1(9), CSNK2A2(5), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTNND1(22), EGFR(20), EP300(29), ERBB2(6), FARP2(18), FER(14), FGFR1(10), FYN(7), IGF1R(13), INSR(18), IQGAP1(12), LEF1(9), LMO7(27), MAP3K7(8), MAPK1(2), MAPK3(4), MET(10), MLLT4(32), NLK(5), PARD3(27), PTPN1(4), PTPRB(31), PTPRF(34), PTPRJ(16), PTPRM(19), PVRL1(9), PVRL2(5), PVRL3(9), PVRL4(5), RAC2(2), RHOA(4), SMAD2(12), SMAD3(4), SMAD4(5), SNAI1(2), SNAI2(8), SORBS1(22), SRC(2), SSX2IP(10), TCF7(4), TCF7L1(5), TCF7L2(18), TGFBR1(8), TGFBR2(6), TJP1(33), VCL(14), WASF1(3), WASF2(5), WASF3(9), WASL(8), YES1(5)	40570967	795	108	770	224	224	304	98	41	114	14	0.0035	0.058
37	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	32	AKT1(8), AKT2(4), AKT3(8), ARHGEF11(22), CDC42(5), DLG4(13), GNA13(9), LPA(14), MAP2K4(6), MAP3K5(21), MAPK8(7), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PDK1(7), PHKA2(15), PI3(3), PIK3CB(19), PLD1(16), PLD2(7), PLD3(3), PTK2(11), RDX(12), ROCK1(27), ROCK2(15), SERPINA4(8), SRF(3)	15807938	299	72	287	78	67	125	37	12	50	8	0.0035	0.058
38	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(37), EP300(29), LPL(11), NCOA1(17), NCOA2(16), PPARG(5), RXRA(1)	6354293	116	50	113	35	29	42	17	8	20	0	0.0040	0.064
39	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(3), AKT1(8), AKT2(4), AKT3(8), BAD(2), BTK(11), CDKN2A(1), DAPP1(7), GRB2(3), GSK3A(9), GSK3B(11), IARS(13), IGFBP1(5), INPP5D(14), PDK1(7), PPP1R13B(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SHC1(11), SOS1(21), SOS2(22), TEC(5), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	11502831	226	63	214	53	49	94	34	9	36	4	0.0041	0.064
40	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	21	GH1(6), GHR(10), GRB2(3), INSR(18), IRS1(17), JAK2(21), MAP2K1(2), MAPK1(2), MAPK3(4), PLCG1(12), PRKCA(10), RAF1(7), RPS6KA1(5), SHC1(11), SLC2A4(4), SOS1(21), SRF(3), STAT5A(5), STAT5B(5)	10024855	166	60	160	51	41	64	25	10	18	8	0.0045	0.070
41	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT1(8), AKT2(4), AKT3(8), GRB2(3), IARS(13), IL13RA1(14), IL2RG(11), IL4R(6), INPP5D(14), JAK2(21), JAK3(9), NR0B2(2), PI3(3), PPP1R13B(7), RPS6KB1(3), SERPINA4(8), SHC1(11), SOS1(21), SOS2(22), SRC(2), STAT6(10), TYK2(7)	11196194	207	61	198	54	42	90	31	10	24	10	0.0047	0.071
42	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(6), CREB1(5), CREBBP(37), EP300(29), NCOA3(8), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), RARA(3), RXRA(1)	6856671	110	50	106	38	30	39	12	6	23	0	0.0050	0.073
43	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT1(8), AKT2(4), AKT3(8), BRD4(9), CAP1(7), CBL(10), CDC42(5), CDKN2A(1), F2RL2(3), FLOT1(1), FLOT2(3), GRB2(3), GSK3A(9), GSK3B(11), IGFBP1(5), IRS1(17), IRS4(20), LNPEP(9), MAPK1(2), MAPK3(4), PARD3(27), PARD6A(1), PDK1(7), PIK3CD(10), PPYR1(7), PTPN1(4), RAF1(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SERPINB6(4), SHC1(11), SLC2A4(4), SORBS1(22), SOS1(21), SOS2(22), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	17688151	340	77	326	101	86	128	54	16	52	4	0.0051	0.073
44	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(11), CREBBP(37), DUSP1(2), EP300(29), IKBKB(15), IL1B(2), IL8(3), MAP2K3(8), MAP2K6(9), MAP3K14(12), MAP3K7(8), MAPK14(6), MYD88(1), NFKB1(12), NFKBIA(3), NR3C1(13), RELA(6), TGFBR1(8), TGFBR2(6), TLR2(12), TNF(1)	9997609	204	57	199	58	50	77	33	12	32	0	0.0058	0.081
45	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	52	AXIN1(8), CCND2(7), CCND3(5), CSNK1E(10), DVL2(12), DVL3(7), FBXW2(3), FOSL1(4), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD6(15), FZD7(5), FZD9(7), GSK3B(11), JUN(1), LDLR(12), MAPK10(9), MAPK9(7), MYC(7), PAFAH1B1(1), PLAU(5), PPP2R5C(6), PPP2R5E(7), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), PRKD1(8), RHOA(4), SFRP4(10), TCF7(4), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1)	16167155	323	75	312	120	103	120	44	18	34	4	0.0062	0.085
46	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	39	AKT1(8), AKT2(4), AKT3(8), BRAF(12), CAB39(6), DDIT4(3), EIF4B(6), FIGF(5), HIF1A(17), IGF1(3), MAPK1(2), MAPK3(4), PDPK1(3), PGF(2), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(9), RHEB(2), RICTOR(25), RPS6(6), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15), RPS6KB1(3), RPS6KB2(6), TSC1(13), TSC2(14), ULK2(10), ULK3(5), VEGFA(1), VEGFB(2), VEGFC(7)	15038358	319	75	305	87	82	123	40	22	52	0	0.0064	0.085
47	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	13	CREBBP(37), EP300(29), FYN(7), IL2RG(11), IL7(2), IL7R(9), JAK3(9), LCK(5), NMI(1), PTK2B(16), STAT5A(5), STAT5B(5)	7436007	136	51	134	47	41	55	15	6	19	0	0.0065	0.085
48	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	35	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCR(6), BLNK(4), BTK(11), CD19(7), CSK(1), DAG1(7), EPHB2(10), GRB2(3), ITPKB(6), LYN(7), MAP2K1(2), MAPK1(2), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PI3(3), PIK3CD(10), PLCG2(27), PPP1R13B(7), RAF1(7), SERPINA4(8), SHC1(11), SOS1(21), SOS2(22), SYK(6), VAV1(16)	16040963	275	72	263	98	69	119	40	13	28	6	0.0073	0.094
49	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	78	ABL1(9), ABL2(19), AKT1(8), AKT2(4), AKT3(8), ARAF(8), BAD(2), BRAF(12), BTC(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CBL(10), CBLB(15), CBLC(5), CDKN1A(1), CDKN1B(5), CRK(1), CRKL(5), EGF(24), EGFR(20), ELK1(2), ERBB2(6), ERBB3(16), ERBB4(29), EREG(4), GAB1(10), GRB2(3), GSK3B(11), HBEGF(3), JUN(1), MAP2K1(2), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MYC(7), NCK1(4), NCK2(8), NRG1(25), NRG2(6), NRG3(15), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(10), PTK2(11), RAF1(7), RPS6KB1(3), RPS6KB2(6), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SRC(2), STAT5A(5), STAT5B(5), TGFA(3)	32592908	658	97	643	165	168	266	92	38	86	8	0.0075	0.095
50	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	19	AKT1(8), AXIN1(8), CD14(2), FZD1(2), GJA1(6), GNAI1(4), GSK3B(11), IRAK1(5), LBP(4), LEF1(9), LY96(4), MYD88(1), NFKB1(12), PDPK1(3), PPP2CA(6), RELA(6), TIRAP(3), TLR4(14), WNT1(1)	5799574	109	47	104	30	21	46	16	6	20	0	0.0084	0.10
51	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	47	ACTA1(4), AGT(7), AKT1(8), CALM2(3), CALM3(1), CALR(4), CAMK1(9), CAMK1G(5), CAMK4(5), CREBBP(37), CSNK1A1(5), EDN1(2), ELSPBP1(6), F2(9), GATA4(1), GSK3B(11), HAND1(5), HAND2(2), IGF1(3), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), MEF2C(11), MYH2(37), NFATC2(15), NFATC3(12), NFATC4(8), NPPA(1), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), RAF1(7), RPS6KB1(3), SYT1(4)	15514446	287	71	276	92	79	111	38	14	45	0	0.0093	0.11
52	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	19	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IL6(2), IL6R(12), IL6ST(10), JAK2(21), JAK3(9), JUN(1), MAP2K1(2), MAPK3(4), PTPN11(8), RAF1(7), SHC1(11), SOS1(21), SRF(3), STAT3(12)	7381993	143	51	139	29	37	54	19	11	14	8	0.0093	0.11
53	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(8), AKT2(4), AKT3(8), ASAH1(9), BRAF(12), DAG1(7), DRD2(10), EGFR(20), EPHB2(10), GRB2(3), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), PI3(3), PIK3CB(19), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), RAF1(7), RGS20(5), SHC1(11), SOS1(21), SOS2(22), SRC(2), STAT3(12), TERF2IP(4)	20237086	366	78	352	118	91	152	54	16	47	6	0.0096	0.11
54	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	22	ATF1(6), CASP2(9), CHUK(11), CRADD(3), IKBKB(15), JUN(1), LTA(3), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K14(12), MAP4K2(6), MAPK14(6), MAPK8(7), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNF(1), TNFRSF1A(6), TRAF2(5)	7062211	147	48	146	34	22	65	26	13	21	0	0.0099	0.11
55	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(8), CAT(5), GH1(6), GHR(10), IGF1(3), IGF1R(13), SHC1(11), SOD1(2), SOD2(3)	3210965	61	35	58	21	9	34	8	5	5	0	0.011	0.12
56	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(5), GRIA2(25), PPP1R1B(4)	1220573	35	22	32	4	4	13	6	0	12	0	0.011	0.12
57	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	26	AKT1(8), CABIN1(15), CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), HDAC5(15), IGF1(3), IGF1R(13), INSR(18), MAP2K6(9), MAPK14(6), MAPK7(17), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MYOD1(3), NFATC2(15), PPP3CA(4), PPP3CB(7), PPP3CC(6), SYT1(4), YWHAH(4)	9956740	191	59	185	66	45	88	22	11	25	0	0.011	0.12
58	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(5), BAD(2), CABIN1(15), CALM2(3), CALM3(1), CAMK2B(2), CAMK4(5), CD3E(2), CD3G(2), CD69(4), CDKN1A(1), CNR1(8), CREBBP(37), CSNK2A1(9), CTLA4(2), EGR2(8), EGR3(9), EP300(29), FCER1A(6), FCGR3A(2), FKBP1B(1), FOS(6), FOSL1(4), GATA3(4), GATA4(1), GSK3A(9), GSK3B(11), ICOS(2), IFNB1(4), IFNG(5), IL10(4), IL1B(2), IL2(4), IL2RA(3), IL6(2), IL8(3), ITK(10), KPNA5(6), MAPK14(6), MAPK8(7), MAPK9(7), MEF2A(5), MEF2B(3), MEF2D(7), MYF5(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB2(10), NFKBIB(3), NFKBIE(6), NPPB(2), NUP214(20), OPRD1(2), P2RX7(3), PAK1(3), PIN1(1), PPIA(2), PPP3CB(7), PPP3CC(6), PPP3R1(2), PTPRC(15), RELA(6), SLA(9), SP1(6), SP3(12), TGFB1(4), TNF(1), TRAF2(5), TRPV6(14), VAV1(16), VAV2(5), VAV3(13), XPO5(10)	30824308	511	91	497	172	141	198	65	24	81	2	0.012	0.12
59	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	144	ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), AGTR2(8), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), CCBP2(3), CCKAR(12), CCKBR(7), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CCR9(2), CCRL1(4), CCRL2(5), CHML(9), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CMKLR1(11), CNR1(8), CNR2(3), CX3CR1(4), CXCR3(5), CXCR4(1), DRD1(6), DRD2(10), DRD3(5), DRD5(11), EDNRA(6), EDNRB(2), F2R(8), F2RL1(3), F2RL2(3), FPR1(4), FSHR(17), GALR1(2), GALR3(3), GALT(2), GHSR(7), GNB2L1(2), GPR17(4), GPR174(11), GPR3(5), GPR37(9), GPR37L1(5), GPR4(7), GPR50(8), GPR6(4), GPR63(5), GPR77(3), GPR83(5), GPR85(7), GPR87(8), GRPR(4), HCRTR1(1), HCRTR2(8), HRH1(9), HRH2(3), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR2A(15), HTR2B(2), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), LHCGR(16), LTB4R(3), MAS1(2), MC3R(8), MC4R(7), MC5R(12), MLNR(3), MTNR1A(6), MTNR1B(4), NMBR(4), NMUR1(8), NMUR2(7), NPY1R(6), NPY2R(4), NPY5R(10), NTSR1(4), NTSR2(2), OPN1SW(6), OPN3(2), OPRD1(2), OPRK1(9), OPRM1(11), OR10A5(5), OR11A1(3), OR12D3(8), OR1F1(3), OR1Q1(3), OR2H1(2), OR5V1(9), OR7A5(6), OR7C1(10), OR8B8(3), OXTR(4), P2RY1(2), P2RY10(6), P2RY11(7), P2RY12(3), P2RY13(3), P2RY14(5), P2RY2(6), P2RY6(3), PPYR1(7), PTAFR(6), PTGDR(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3), RGR(6), RHO(8), RRH(3), SSTR2(3), SSTR3(6), SUCNR1(3), TRHR(5)	37910419	836	102	815	303	239	370	126	36	65	0	0.012	0.13
60	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), PRKCE(11), SOD1(2)	2802036	83	35	78	32	30	30	9	4	10	0	0.013	0.13
61	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8)	907722	21	16	21	6	1	13	1	0	6	0	0.013	0.13
62	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	26	AKT1(8), AKT2(4), AKT3(8), ANKRD6(14), AXIN1(8), AXIN2(1), CER1(2), CSNK1A1(5), DACT1(14), DKK1(4), DKK2(4), DKK3(3), DKK4(3), FSTL1(3), GSK3A(9), GSK3B(11), LRP1(53), MVP(12), NKD1(4), PIN1(1), PSEN1(4), PTPRA(11), SENP2(11), SFRP1(5), TSHB(3), WIF1(5)	10719150	210	62	201	62	68	85	24	9	24	0	0.013	0.13
63	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	65	ACACB(31), ACSL1(13), ACSL3(10), ACSL5(18), ACSL6(13), ADIPOQ(3), ADIPOR1(2), ADIPOR2(9), AGRP(2), AKT1(8), AKT2(4), AKT3(8), CAMKK1(8), CAMKK2(6), CD36(7), CHUK(11), CPT1A(10), CPT1C(15), CPT2(7), G6PC(6), G6PC2(9), IKBKB(15), IRS1(17), IRS4(20), JAK2(21), JAK3(9), LEP(2), LEPR(15), MAPK10(9), MAPK8(7), MAPK9(7), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NPY(2), PCK1(15), PCK2(7), POMC(2), PPARA(2), PPARGC1A(13), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKAG1(2), PRKAG2(4), PRKAG3(6), PRKCQ(13), PTPN11(8), RELA(6), RXRA(1), RXRG(10), SLC2A1(6), SLC2A4(4), STAT3(12), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5), TYK2(7)	26702514	515	93	501	164	114	231	75	24	61	10	0.014	0.13
64	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(21), GABBR1(17), GPRC5A(5), GPRC5B(8), GPRC5C(4), GPRC5D(4), GRM1(22), GRM2(7), GRM3(20), GRM4(16), GRM5(22), GRM7(15), GRM8(24)	7183145	185	52	179	57	63	55	32	7	26	2	0.014	0.13
65	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	15	AKT1(8), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF4E(4), GSK3B(11), IGF1(3), IGF1R(13), PDK2(5), PDPK1(3), PPP2CA(6), RPS6(6), RPS6KB1(3)	4523075	80	40	76	27	18	37	8	4	13	0	0.014	0.13
66	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(8), CD8A(3), CSF1(5), CSF3(1), EPO(2), IL2(4), IL5(2), IL6(2), IL7(2), IL8(3)	2125427	32	25	32	12	12	10	4	0	6	0	0.014	0.13
67	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(5), GRB2(3), HBXIP(1), PTK2B(16), SHC1(11), SOS1(21), SRC(2)	2976267	59	33	57	15	15	28	6	4	4	2	0.015	0.13
68	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	29	CD14(2), CHUK(11), ELK1(2), FOS(6), IKBKB(15), IRAK1(5), JUN(1), LY96(4), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K14(12), MAP3K7(8), MAPK14(6), MAPK8(7), MYD88(1), NFKB1(12), NFKBIA(3), PPARA(2), RELA(6), TIRAP(3), TLR10(19), TLR2(12), TLR3(6), TLR4(14), TLR6(10), TLR7(15), TLR9(7), TRAF6(4)	11527687	216	61	214	57	47	85	40	15	27	2	0.015	0.14
69	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(37), EP300(29), MAPK1(2), MAPK3(4), PELP1(13), SRC(2)	4587366	87	40	85	24	23	33	11	4	16	0	0.016	0.14
70	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(8), CSF1(5), CSF3(1), HLA-DRB1(1), IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL15(1), IL1A(1), IL2(4), IL5(2), IL6(2), IL7(2), IL8(3), LTA(3), TGFB1(4), TGFB2(6), TGFB3(9), TNF(1)	4610788	76	39	74	27	23	34	10	1	8	0	0.016	0.14
71	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(8), PLCB1(6), PLCG1(12), PRKCA(10), VAV1(16)	3203795	52	34	45	25	12	20	7	4	7	2	0.017	0.14
72	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	25	DUSP1(2), GORASP1(7), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK8IP1(5), MAPK9(7), MAPKAPK5(6), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PIK3CD(10), SYT1(4), TRAF2(5), TRAF3(6), TRAF5(8), TRAF6(4)	8308118	136	54	135	35	34	58	16	4	22	2	0.017	0.14
73	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	65	AKT1(8), AKT2(4), AKT3(8), BTK(11), FCER1A(6), FCER1G(1), FYN(7), GAB2(12), GRB2(3), IL5(2), INPP5D(14), LCP2(7), LYN(7), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK9(7), MS4A2(4), PDK1(7), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCG1(12), PLCG2(27), PRKCA(10), PRKCD(7), PRKCE(11), RAC2(2), RAF1(7), SOS1(21), SOS2(22), SYK(6), TNF(1), VAV1(16), VAV2(5), VAV3(13)	21904350	435	86	421	131	112	167	60	25	63	8	0.017	0.15
74	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	240	ACVR1(9), ACVR1B(6), ACVR2B(8), AMHR2(4), BMP2(5), BMPR1A(8), BMPR1B(6), BMPR2(14), CCL1(1), CCL13(2), CCL14(1), CCL15(2), CCL16(1), CCL17(1), CCL18(2), CCL23(3), CCL24(3), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL5(4), CCL7(4), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CCR9(2), CD27(2), CD40(4), CD40LG(7), CD70(2), CLCF1(2), CNTF(3), CNTFR(2), CSF1(5), CSF1R(7), CSF2RA(9), CSF2RB(11), CSF3(1), CSF3R(11), CX3CL1(4), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL12(3), CXCL13(2), CXCL14(1), CXCL16(3), CXCL2(2), CXCL3(1), CXCL5(3), CXCL6(1), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(3), EDA(7), EDA2R(9), EGF(24), EGFR(20), EPO(2), EPOR(4), FAS(7), FASLG(6), FLT1(23), FLT3(9), FLT3LG(4), FLT4(10), GDF5(8), GH1(6), GH2(5), GHR(10), HGF(15), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), IFNK(2), IFNW1(2), IL10(4), IL10RA(7), IL10RB(9), IL11RA(7), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL13RA1(14), IL15(1), IL15RA(3), IL17RA(10), IL17RB(5), IL18(1), IL18R1(5), IL18RAP(12), IL19(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), IL1RAP(2), IL2(4), IL20(6), IL20RA(3), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(8), IL24(7), IL25(2), IL26(7), IL28A(2), IL28B(4), IL28RA(8), IL29(2), IL2RA(3), IL2RB(6), IL2RG(11), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL6ST(10), IL7(2), IL7R(9), IL8(3), INHBA(7), INHBB(3), INHBC(4), INHBE(7), KDR(23), KIT(28), KITLG(2), LEP(2), LEPR(15), LIF(3), LIFR(22), LTA(3), LTB(1), LTBR(7), MET(10), MPL(5), NGFR(4), OSM(3), OSMR(12), PDGFB(4), PDGFC(4), PDGFRA(29), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(3), PRL(6), PRLR(6), RELT(1), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFRSF11A(6), TNFRSF11B(6), TNFRSF13B(4), TNFRSF14(2), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(1), TNFRSF8(8), TNFRSF9(3), TNFSF10(1), TNFSF11(6), TNFSF12(4), TNFSF13B(3), TNFSF14(6), TNFSF15(3), TNFSF18(3), TNFSF4(5), TNFSF8(1), TPO(18), TSLP(2), VEGFA(1), VEGFB(2), VEGFC(7), XCL1(1), XCL2(1), XCR1(7)	59567882	1162	114	1136	359	330	451	162	63	152	4	0.018	0.15
75	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	23	ADCY1(17), AKT1(8), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CREB1(5), GNAS(25), GRB2(3), MAPK1(2), MAPK14(6), MAPK3(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), RPS6KA1(5), RPS6KA5(7), SOS1(21)	8129107	159	52	149	40	34	70	17	12	24	2	0.020	0.16
76	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IGF1(3), IGF1R(13), IRS1(17), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PTPN11(8), RAF1(7), SHC1(11), SOS1(21), SRF(3)	6528285	117	48	114	29	33	48	15	8	11	2	0.021	0.17
77	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(7), ATF2(6), CALM2(3), CALM3(1), EGFR(20), ELK1(2), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(6), MAPK1(2), MAPK3(4), MAPK8(7), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), PAK1(3), PRKCA(10), PTK2(11), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), SRC(2), SYT1(4)	10570731	175	58	171	62	43	69	24	12	25	2	0.021	0.17
78	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(4), AKT1(8), BDKRB2(9), CALM2(3), CALM3(1), CHRM1(6), CHRNA1(6), FLT1(23), FLT4(10), KDR(23), NOS3(11), PDE2A(14), PDE3A(17), PDE3B(15), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKG1(9), PRKG2(10), RYR2(111), SLC7A1(6), SYT1(4), TNNI1(1)	13283381	312	63	302	103	75	133	42	15	38	9	0.022	0.17
79	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(9), LPO(6), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), TPO(18), TYR(10)	3243469	76	36	75	23	27	31	10	1	7	0	0.023	0.18
80	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(38), CDC25C(8), CHEK1(4), CHEK2(14), YWHAH(4)	3186587	68	33	65	7	9	22	9	7	19	2	0.023	0.18
81	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(30), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(12), ANAPC7(3), BTRC(13), CDC16(1), CDC20(5), CDC23(4), CDC27(22), CUL1(12), CUL2(7), CUL3(18), FBXW11(5), ITCH(8), RBX1(1), SKP1(2), SKP2(6), SMURF1(10), SMURF2(4), TCEB1(2), UBA1(20), UBE2C(1), UBE2D2(3), UBE2D3(3), UBE2D4(1), UBE2E1(3), UBE2E2(3), UBE2E3(8), VHL(2), WWP1(18), WWP2(7)	13369421	247	66	241	51	49	106	40	24	28	0	0.024	0.18
82	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(3), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADK(1), ADSL(7), ADSS(8), AK1(2), AK2(4), AK5(6), ALLC(10), AMPD1(21), AMPD2(9), AMPD3(4), ATIC(9), ATP1B1(3), ATP5A1(11), ATP5B(4), ATP5C1(1), ATP5F1(5), ATP5G1(4), ATP5G2(1), ATP5I(1), ATP5J(4), CANT1(5), DCK(4), DGUOK(3), ENPP1(11), ENPP3(16), ENTPD1(6), FHIT(2), GART(8), GDA(5), GMPS(13), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(10), ITPA(1), NPR1(14), NPR2(16), NT5C(1), NT5E(6), NT5M(4), NUDT2(3), PAICS(4), PAPSS1(6), PAPSS2(6), PDE1A(12), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE5A(14), PDE6B(6), PDE6C(14), PDE7B(4), PDE8A(7), PDE9A(10), PFAS(10), PKLR(10), PKM2(5), POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), PPAT(10), PRPS1(3), PRPS1L1(5), PRPS2(10), PRUNE(4), RRM1(4), RRM2(5)	42966703	763	100	751	225	195	326	98	46	96	2	0.024	0.18
83	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(4), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), XYLT1(15), XYLT2(9)	2082646	44	27	43	16	14	19	5	1	5	0	0.025	0.19
84	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(4), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), XYLT1(15), XYLT2(9)	2082646	44	27	43	16	14	19	5	1	5	0	0.025	0.19
85	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IL2(4), IL2RA(3), IL2RB(6), IL2RG(11), JAK3(9), JUN(1), LCK(5), MAP2K1(2), MAPK3(4), MAPK8(7), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5), SYK(6)	7259864	127	49	124	24	41	52	12	8	12	2	0.028	0.20
86	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	35	AKT1(8), ASAH1(9), ATF1(6), BRAF(12), CAMP(1), CREB1(5), CREB3(2), CREB5(6), CREBBP(37), CRKL(5), DAG1(7), EGR1(8), EGR2(8), EGR3(9), ELK1(2), FRS2(7), JUN(1), MAP1B(42), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK8IP1(5), MAPK9(7), NTRK1(11), OPN1LW(4), PIK3C2G(22), PIK3CD(10), PTPN11(8), RPS6KA3(17), SHC1(11), SRC(2), TERF2IP(4)	14722161	304	66	296	95	84	123	35	14	41	7	0.029	0.21
87	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	99	ABL1(9), ANAPC1(30), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(12), ANAPC7(3), ATR(38), BUB1(9), BUB1B(6), BUB3(5), CCNA1(4), CCNA2(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND2(7), CCND3(5), CCNE2(6), CCNH(3), CDC14A(8), CDC14B(6), CDC16(1), CDC20(5), CDC23(4), CDC25A(9), CDC25B(3), CDC25C(8), CDC27(22), CDC6(3), CDC7(13), CDK2(5), CDK4(4), CDK6(3), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), CHEK1(4), CHEK2(14), CREBBP(37), CUL1(12), DBF4(11), E2F2(1), E2F3(5), EP300(29), ESPL1(10), GSK3B(11), HDAC1(4), HDAC2(5), MAD1L1(15), MAD2L1(5), MAD2L2(3), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), PCNA(3), PLK1(6), PRKDC(70), PTTG1(5), PTTG2(1), RBL1(17), RBL2(21), RBX1(1), SKP1(2), SKP2(6), SMAD2(12), SMAD3(4), SMAD4(5), SMC1A(19), SMC1B(22), TGFB1(4), TGFB2(6), TGFB3(9), WEE1(1), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	43724094	751	104	726	170	174	316	96	45	104	16	0.029	0.21
88	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), NAT1(10), NAT2(3), XDH(10)	2863937	52	32	48	21	18	25	5	1	3	0	0.030	0.21
89	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(8), EIF4A1(4), EIF4A2(6), EIF4E(4), EIF4G1(15), EIF4G2(8), EIF4G3(26), GHR(10), IRS1(17), MAPK1(2), MAPK14(6), MAPK3(4), MKNK1(6), PABPC1(11), PDK2(5), PDPK1(3), PRKCA(10), RPS6KB1(3)	8263425	148	50	145	35	32	62	22	10	22	0	0.030	0.21
90	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	24	ADRBK1(3), AKT1(8), AKT2(4), AKT3(8), DAG1(7), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PDK1(7), PHKA2(15), PIK3CB(19), PLD1(16), PLD2(7), PLD3(3), VN1R1(5)	15004181	236	65	229	76	61	104	27	9	33	2	0.031	0.21
91	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	73	AIFM1(12), AKT1(8), AKT2(4), AKT3(8), APAF1(19), BAD(2), BAX(4), BCL2L1(3), BID(3), BIRC2(13), BIRC3(3), CAPN1(4), CAPN2(6), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CFLAR(7), CHUK(11), CSF2RB(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1RAP(2), IL3RA(11), IRAK1(5), IRAK2(7), IRAK3(13), IRAK4(6), MAP3K14(12), MYD88(1), NFKB1(12), NFKB2(10), NFKBIA(3), NTRK1(11), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), RELA(6), RIPK1(8), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFRSF1A(6), TNFSF10(1), TRAF2(5)	23576155	447	82	434	144	99	190	58	30	70	0	0.032	0.21
92	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(11), GOT1(6), GOT2(5), TAT(9), TYR(10)	1635238	41	24	40	5	8	17	7	3	6	0	0.035	0.23
93	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	100	ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), ARHGAP5(24), CD99(2), CDC42(5), CDH5(9), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTNND1(22), CXCL12(3), CXCR4(1), CYBB(12), ESAM(1), EZR(6), F11R(2), GNAI1(4), GNAI2(7), GNAI3(3), ICAM1(3), ITGA4(12), ITGAL(13), ITGAM(24), ITGB1(12), ITGB2(14), ITK(10), JAM2(9), JAM3(3), MAPK13(2), MAPK14(6), MLLT4(32), MMP2(11), MMP9(14), MSN(15), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLPF(2), NCF1(5), NCF2(6), NCF4(8), NOX1(11), NOX3(5), OCLN(5), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(10), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAC2(2), RAP1A(3), RAP1B(2), RAPGEF3(11), RAPGEF4(10), RASSF5(3), RHOA(4), RHOH(2), ROCK1(27), ROCK2(15), SIPA1(3), THY1(1), TXK(6), VASP(2), VAV1(16), VAV2(5), VAV3(13), VCAM1(9), VCL(14)	39838910	793	105	773	263	221	313	96	38	115	10	0.036	0.23
94	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(12), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), DDC(11), EPX(14), GOT1(6), GOT2(5), HPD(7), LPO(6), MAOA(14), MAOB(7), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), TAT(9), TPO(18)	7537821	167	50	162	51	48	66	23	8	22	0	0.036	0.23
95	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	20	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(6), MAPK3(4), MAPK8(7), PDGFRA(29), PLCG1(12), PRKCA(10), RAF1(7), SHC1(11), SOS1(21), SRF(3), STAT1(14), STAT3(12), STAT5A(5)	8218254	164	52	156	36	46	62	24	10	18	4	0.036	0.23
96	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(2), ACP5(4), ACPP(5), ACPT(7), ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), CYP19A1(12), CYP1A1(9), CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2D6(2), CYP2E1(5), CYP2F1(5), CYP2J2(5), CYP3A4(14), CYP3A5(7), CYP3A7(9), CYP4B1(4), CYP4F8(9), CYP51A1(4), PON1(12)	10164909	195	55	190	60	57	74	31	11	20	2	0.039	0.25
97	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	22	ATF2(6), BCR(6), BLNK(4), ELK1(2), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAPK1(2), MAPK3(4), PAPPA(32), RPS6KA1(5), RPS6KA3(17), SHC1(11), SOS1(21), SYK(6), VAV1(16), VAV2(5), VAV3(13)	8945770	169	54	163	52	50	61	25	7	22	4	0.039	0.25
98	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	52	BMP2(5), BMP4(7), BMP6(6), BMP8A(3), BMP8B(1), BTRC(13), CSNK1A1(5), CSNK1A1L(4), CSNK1E(10), CSNK1G1(8), CSNK1G3(11), DHH(2), FBXW11(5), GLI1(12), GLI2(11), GLI3(21), GSK3B(11), HHIP(12), IHH(3), LRP2(72), PRKACA(4), PRKACB(2), PRKACG(6), PRKX(4), PTCH1(23), PTCH2(21), RAB23(4), SHH(7), SMO(6), STK36(11), SUFU(7), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1), ZIC2(1)	19434285	379	75	367	129	119	149	46	13	50	2	0.040	0.25
99	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(6), BAD(2), BRAF(12), CREB1(5), CREB3(2), CREB5(6), DUSP4(1), DUSP6(1), DUSP9(8), EEF2K(11), EIF4E(4), GRB2(3), MAP2K1(2), MAP3K8(12), MAPK1(2), MAPK3(4), MKNK1(6), MKNK2(4), MOS(8), NFKB1(12), RAP1A(3), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), SHC1(11), SOS1(21), SOS2(22), TRAF3(6)	9970363	212	59	204	48	42	91	32	12	31	4	0.040	0.25
100	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	122	ACTB(5), CHAD(3), COL11A1(36), COL11A2(13), COL17A1(24), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), COMP(7), DES(5), DSC2(17), DSG2(8), DSG4(18), FN1(39), GJA1(6), GJA10(7), GJA4(2), GJA8(6), GJA9(12), GJB1(1), GJB2(3), GJB3(2), GJB4(5), GJB5(3), GJB6(4), GJB7(8), GJC1(2), GJC3(4), GJD2(8), GJD4(3), IBSP(6), INA(2), ITGA6(12), ITGB4(12), KRT1(8), KRT10(1), KRT12(7), KRT13(9), KRT14(3), KRT15(10), KRT16(8), KRT17(4), KRT19(4), KRT2(9), KRT20(4), KRT23(9), KRT24(5), KRT25(6), KRT27(7), KRT28(5), KRT3(9), KRT31(12), KRT32(9), KRT33A(7), KRT33B(4), KRT34(9), KRT35(7), KRT36(7), KRT37(7), KRT38(9), KRT4(10), KRT5(6), KRT6A(5), KRT6B(10), KRT6C(6), KRT7(1), KRT71(5), KRT72(7), KRT73(4), KRT74(3), KRT75(7), KRT76(10), KRT77(4), KRT78(4), KRT79(5), KRT8(4), KRT81(5), KRT82(5), KRT83(3), KRT84(9), KRT85(5), KRT86(1), KRT9(13), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), LMNA(8), LMNB1(5), PRPH(2), RELN(48), SPP1(3), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNC(19), TNN(16), TNR(16), TNXB(25), VIM(8), VWF(31)	76149463	1414	121	1384	458	409	589	182	65	138	31	0.041	0.25
101	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABARAP(2), GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), GPHN(13), NSF(3), SRC(2), UBQLN1(8)	4203532	103	40	97	33	31	41	12	6	13	0	0.041	0.25
102	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(9), DPM2(4), ELK1(2), FOS(6), GRB2(3), JUN(1), KLK2(2), MAP2K1(2), MAPK3(4), MAPK8(7), NGFR(4), PLCG1(12), RAF1(7), SHC1(11), SOS1(21)	5272579	95	42	90	17	30	35	11	6	11	2	0.041	0.25
103	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15), THY1(1)	3855787	71	36	70	29	14	38	7	2	10	0	0.042	0.25
104	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(7), IFNG(5), IL12A(7), IL12B(3), IL18(1), IL2(4)	1094142	27	20	26	7	9	8	5	2	3	0	0.043	0.25
105	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	19	AKT1(8), BCR(6), CRKL(5), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAP2K4(6), MAPK3(4), MAPK8(7), MYC(7), RAF1(7), SOS1(21), STAT1(14), STAT5A(5), STAT5B(5)	7198202	128	48	121	29	32	50	21	7	10	8	0.044	0.25
106	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCL2L1(3), CDC42(5), CDK2(5), CDKN1B(5), CDKN2A(1), CREB1(5), CREB3(2), CREB5(6), ERBB4(29), F2RL2(3), GAB1(10), GRB2(3), GSK3A(9), GSK3B(11), IFI27(1), IGF1(3), IGFBP1(5), IRS1(17), IRS4(20), MET(10), MYC(7), NOLC1(10), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PARD3(27), PARD6A(1), PDK1(7), PIK3CD(10), PPP1R13B(7), PREX1(25), PTK2(11), PTPN1(4), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SHC1(11), SLC2A4(4), SOS1(21), SOS2(22), TSC1(13), TSC2(14), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	23670799	463	82	446	121	97	198	74	27	63	4	0.044	0.25
107	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	25	CALM2(3), CALM3(1), CRKL(5), GRB2(3), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), PAK1(3), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), SRC(2), SYT1(4)	8210128	134	52	130	45	34	50	19	11	18	2	0.045	0.25
108	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	47	ADORA3(5), ALG6(5), CCKBR(7), CCR2(6), CCR3(5), CELSR2(30), CELSR3(23), CHRM2(9), CHRM3(9), CIDEB(3), CXCR3(5), EDNRA(6), EMR2(5), EMR3(8), F2R(8), FSHR(17), GHRHR(2), GNRHR(4), GPR116(20), GPR132(8), GPR133(11), GPR17(4), GPR18(2), GPR55(4), GPR56(3), GPR61(7), GPR77(3), GPR84(6), GRM1(22), GRPR(4), HRH4(4), LGR6(18), LPHN2(30), LPHN3(29), LTB4R2(3), NTSR1(4), OR8G1(1), OR8G2(6), P2RY11(7), P2RY13(3), PTGFR(10), SMO(6), SSTR2(3), TAAR5(8), TSHR(12), VN1R1(5)	20044213	400	79	395	120	118	156	56	26	42	2	0.045	0.25
109	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(8), BAD(2), CASP9(3), CHUK(11), GH1(6), GHR(10), NFKB1(12), NFKBIA(3), PDPK1(3), PPP2CA(6), RELA(6), YWHAH(4)	3684663	74	33	71	8	12	34	15	5	8	0	0.045	0.25
110	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(4), GBA3(9), LPO(6), MPO(9), PRDX6(2), TPO(18)	2853182	62	34	61	20	25	21	7	2	7	0	0.045	0.25
111	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(4), ARSB(6), FUCA1(3), FUCA2(3), GBA(4), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), HGSNAT(9), HPSE(4), HPSE2(5), HYAL1(4), HYAL2(1), IDS(6), LCT(30), MAN2B1(20), MAN2B2(9), MAN2C1(8), MANBA(14), NAGLU(3), NEU2(5), NEU3(3), SPAM1(12)	11375922	176	58	171	72	49	79	21	11	16	0	0.045	0.25
112	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(24), C5(20), C6(23), C7(21), ICAM1(3), IL1A(1), IL6(2), IL8(3), ITGA4(12), ITGAL(13), ITGB1(12), ITGB2(14), SELP(15), SELPLG(11), TNF(1), VCAM1(9)	8463946	184	52	176	47	44	82	19	9	26	4	0.046	0.25
113	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	16	ADCY1(17), ARHGEF1(11), F2(9), F2R(8), GNA12(10), GNA13(9), GNAI1(4), GNB1(3), MAP3K7(8), PLCB1(6), PPP1R12B(18), PRKCA(10), PTK2B(16), ROCK1(27)	7453215	156	50	153	40	48	57	20	10	15	6	0.046	0.25
114	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(10), ABAT(9), ADSL(7), ADSS(8), AGXT(5), AGXT2(9), ASL(4), ASNS(9), ASPA(5), CAD(38), CRAT(3), DARS(4), DDO(9), GAD1(8), GAD2(12), GOT1(6), GOT2(5), GPT2(7), NARS(7), PC(8)	8647259	173	56	171	51	40	77	26	5	25	0	0.047	0.25
115	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	34	ANKHD1(3), EEF1B2(3), EEF1D(9), EEF1G(4), EEF2(8), EEF2K(11), EIF1AX(4), EIF2AK1(12), EIF2AK2(16), EIF2AK3(14), EIF2B1(1), EIF2B2(4), EIF2B3(8), EIF2B4(5), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF4A1(4), EIF4A2(6), EIF4E(4), EIF4EBP2(1), EIF4G1(15), EIF4G3(26), EIF5(3), EIF5A(7), EIF5B(17), ETF1(5), GSPT2(14), PABPC1(11), PABPC3(13), PAIP1(4), SLC35A4(4)	14070408	254	70	248	54	68	100	35	11	36	4	0.047	0.25
116	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	40	IMPA1(4), IMPA2(6), INPP1(2), INPP4B(17), INPP5A(6), INPP5B(8), IPMK(7), ITGB1BP3(1), ITPK1(2), ITPKB(6), MINPP1(5), OCRL(20), PI4KA(18), PI4KB(12), PIK3C3(11), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PTPMT1(1), SYNJ1(27), SYNJ2(13)	21833606	415	80	404	134	113	155	63	24	58	2	0.048	0.26
117	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(4), EGFR(20), ELK1(2), GNAS(25), GNB1(3), GRB2(3), IGF1R(13), ITGB1(12), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(4), MKNK1(6), MKNK2(4), MYC(7), NGFR(4), PDGFRA(29), PPP2CA(6), PTPRR(18), RAF1(7), RPS6KA1(5), RPS6KA5(7), SHC1(11), SOS1(21), SRC(2), STAT3(12)	10992088	231	61	223	50	56	98	32	12	29	4	0.051	0.27
118	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	69	ARAF(8), BRAF(12), C7orf16(3), CACNA1A(19), CRHR1(2), GNA11(3), GNA12(10), GNA13(9), GNAI1(4), GNAI2(7), GNAI3(3), GNAO1(5), GNAS(25), GNAZ(7), GRIA1(12), GRIA2(25), GRID2(13), GRM1(22), GRM5(22), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), IGF1(3), IGF1R(13), ITPR1(31), ITPR2(38), ITPR3(23), LYN(7), MAP2K1(2), MAPK1(2), MAPK3(4), NOS1(21), NOS3(11), NPR1(14), NPR2(16), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PPP2CA(6), PPP2CB(2), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PRKCA(10), PRKCG(10), PRKG1(9), PRKG2(10), RAF1(7), RYR1(80)	36550509	724	98	705	235	182	298	125	30	85	4	0.051	0.27
119	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	25	ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), DRD1(6), DRD2(10), DRD3(5), DRD5(11), HRH1(9), HRH2(3), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR2A(15), HTR2B(2), HTR4(7), HTR5A(9), HTR6(4), HTR7(4)	7414258	190	53	184	78	66	81	31	5	7	0	0.052	0.27
120	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(17), CD3D(3), CD3E(2), CD3G(2), CD4(8), CREBBP(37), CSK(1), GNAS(25), GNB1(3), HLA-DRB1(1), LCK(5), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PTPRC(15), ZAP70(10)	7419038	150	50	145	46	37	70	13	8	22	0	0.053	0.27
121	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(17), CD3D(3), CD3E(2), CD3G(2), CD4(8), CREBBP(37), CSK(1), GNAS(25), GNB1(3), HLA-DRB1(1), LCK(5), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PTPRC(15), ZAP70(10)	7419038	150	50	145	46	37	70	13	8	22	0	0.053	0.27
122	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	75	ACVR1(9), ACVR1B(6), ACVRL1(3), AKT1(8), AURKB(5), BMPR1A(8), BMPR2(14), BUB1(9), CDIPT(1), CDKL1(7), CDKL2(6), CDS1(3), CDS2(2), CLK1(9), CLK2(10), CLK4(6), COL4A3BP(3), CSNK2A1(9), CSNK2A2(5), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), IMPA1(4), INPP1(2), INPP4B(17), INPP5A(6), ITPKB(6), MAP3K10(7), MOS(8), NEK1(20), NEK3(12), OCRL(20), PAK4(2), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3CB(19), PIK3CG(25), PIM2(3), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCG1(12), PLCG2(27), PLK3(12), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), PRKG1(9), RAF1(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KB1(3), TGFBR1(8), VRK1(12)	36298603	700	96	678	226	192	259	106	41	96	6	0.053	0.27
123	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(17), GNAS(25), GNB1(3), PRKACA(4), PRKAR1A(4)	2068545	53	29	51	10	14	27	3	4	5	0	0.053	0.27
124	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	78	ACVR1(9), ACVR1B(6), ACVR1C(7), ACVR2B(8), ACVRL1(3), AMHR2(4), BMP2(5), BMP4(7), BMP6(6), BMP8A(3), BMP8B(1), BMPR1A(8), BMPR1B(6), BMPR2(14), CHRD(14), COMP(7), CREBBP(37), CUL1(12), DCN(11), E2F4(3), E2F5(1), EP300(29), FST(7), GDF5(8), GDF6(4), ID1(2), ID2(1), IFNG(5), INHBA(7), INHBB(3), INHBC(4), INHBE(7), LEFTY1(2), LEFTY2(3), LTBP1(19), MAPK1(2), MAPK3(4), MYC(7), NODAL(2), NOG(1), PPP2CA(6), PPP2CB(2), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), RBL1(17), RBL2(21), RBX1(1), RHOA(4), ROCK1(27), ROCK2(15), RPS6KB1(3), RPS6KB2(6), SKP1(2), SMAD1(1), SMAD2(12), SMAD3(4), SMAD4(5), SMAD5(9), SMAD9(1), SMURF1(10), SMURF2(4), SP1(6), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNF(1), ZFYVE16(22), ZFYVE9(16)	31591498	605	93	589	168	176	219	85	26	88	11	0.054	0.27
125	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(8), AP2A1(7), AP2M1(6), ARF1(4), BAD(2), BTK(11), EEA1(20), GRASP(3), GSK3A(9), GSK3B(11), LYN(7), PDPK1(3), PFKM(7), PFKP(11), PLCG1(12), PRKCE(11), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(5)	8006261	146	52	138	54	43	60	19	7	17	0	0.055	0.27
126	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(14), LPO(6), MPO(9), MTHFR(7), PRDX6(2), SHMT1(6), SHMT2(8), TPO(18)	3889486	78	37	77	19	26	30	7	2	11	2	0.056	0.27
127	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(1), ANXA3(8), ANXA4(8), ANXA5(3), ANXA6(10), CYP11A1(10), EDN1(2), EDNRA(6), EDNRB(2), HPGD(2), HSD11B1(4), PLA2G4A(11), PRL(6), PTGDR(6), PTGDS(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3), PTGIS(8), PTGS1(8), PTGS2(7), SCGB1A1(1), TBXAS1(6)	7229033	145	48	144	43	45	54	19	7	20	0	0.056	0.27
128	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	90	AKT1(8), AKT2(4), AKT3(8), CCL3(1), CCL4(1), CCL5(4), CD14(2), CD40(4), CD80(7), CD86(6), CHUK(11), CXCL10(2), CXCL11(1), CXCL9(2), FADD(1), FOS(6), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IKBKB(15), IKBKE(3), IL12A(7), IL12B(3), IL1B(2), IL6(2), IL8(3), IRAK1(5), IRAK4(6), IRF3(6), IRF5(3), JUN(1), LBP(4), LY96(4), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K7(8), MAP3K8(12), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK9(7), MYD88(1), NFKB1(12), NFKB2(10), NFKBIA(3), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), RELA(6), RIPK1(8), SPP1(3), STAT1(14), TBK1(6), TICAM1(8), TICAM2(5), TIRAP(3), TLR1(12), TLR2(12), TLR3(6), TLR4(14), TLR5(8), TLR6(10), TLR7(15), TLR8(18), TLR9(7), TNF(1), TRAF3(6), TRAF6(4)	28278719	531	88	519	149	131	215	80	31	72	2	0.056	0.27
129	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	29	AKT1(8), AR(5), ASAH1(9), BRAF(12), CAMP(1), CCL13(2), CCL15(2), CCL16(1), DAG1(7), EGFR(20), GNA11(3), GNA15(1), GNAI1(4), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), MAPK10(9), MAPK14(6), PHKA2(15), PIK3CD(10), PTX3(2), RAF1(7), SRC(2)	14822541	251	65	245	86	66	111	35	6	29	4	0.056	0.27
130	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(5), CD4(8), HLA-DRB1(1), IL1B(2), IL5(2), IL5RA(9), IL6(2)	1925145	29	21	27	11	3	15	1	0	10	0	0.058	0.27
131	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	8	ALDOA(6), CTSD(5), GREB1(16), HSPB2(1), MTA1(4), MTA3(5), PDZK1(4), TUBA8(11)	3076886	52	31	52	17	12	24	4	5	7	0	0.059	0.28
132	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(4)	181162	4	4	4	1	2	1	0	0	1	0	0.060	0.28
133	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(10), CTH(5), GOT1(6), GOT2(5), LDHA(6), LDHB(2), LDHC(3)	2295356	37	28	36	17	8	14	3	4	8	0	0.060	0.28
134	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(10), GLS2(9), GLUD1(4), GLUD2(9)	1451447	32	21	31	11	8	12	5	1	6	0	0.061	0.28
135	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(17), AKT1(8), BAD(2), BAX(4), BCL2L1(3), CSF2RB(11), IGF1(3), IGF1R(13), IL3RA(11), KIT(28), KITLG(2), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), YWHAH(4)	5871035	127	43	121	42	33	56	13	10	15	0	0.063	0.28
136	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(2), CAT(5), EPX(14), LPO(6), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), SHMT1(6), SHMT2(8), TPO(18)	3906933	81	38	80	23	28	34	7	2	8	2	0.063	0.28
137	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	18	AMPH(17), AP2A1(7), AP2M1(6), BIN1(3), CALM2(3), CALM3(1), DNM1(5), EPS15(12), PICALM(13), PPP3CA(4), PPP3CB(7), PPP3CC(6), SYNJ1(27), SYNJ2(13), SYT1(4)	7388446	128	49	124	44	37	43	24	7	17	0	0.063	0.28
138	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	88	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ATF4(4), CACNA1C(30), CACNA1D(34), CACNA1F(36), CACNA1S(33), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CDC42(5), CGA(1), EGFR(20), ELK1(2), GNA11(3), GNAS(25), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(3), ITPR1(31), ITPR2(38), ITPR3(23), JUN(1), LHB(3), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK7(17), MAPK8(7), MAPK9(7), MMP14(5), MMP2(11), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLD1(16), PLD2(7), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCD(7), PRKX(4), PTK2B(16), RAF1(7), SOS1(21), SOS2(22), SRC(2)	42244445	799	101	780	253	214	347	98	39	89	12	0.063	0.28
139	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(7), GSTZ1(4)	463421	11	10	11	1	0	6	1	2	2	0	0.064	0.28
140	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(13), CD14(2), CD19(7), CD1A(5), CD1B(3), CD1D(3), CD1E(6), CD2(4), CD22(13), CD33(11), CD34(4), CD36(7), CD37(1), CD38(7), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD44(12), CD5(7), CD55(6), CD59(2), CD8A(3), CD8B(1), CD9(4), CR1(28), CSF1(5), CSF1R(7), CSF2RA(9), CSF3(1), CSF3R(11), DNTT(6), EPO(2), EPOR(4), FCER2(2), FCGR1A(7), FLT3(9), FLT3LG(4), GP1BA(11), GP5(5), GYPA(2), HLA-DRB1(1), HLA-DRB5(1), IL11RA(7), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), IL2RA(3), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL7(2), IL7R(9), ITGA1(20), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGAM(24), ITGB3(16), KIT(28), KITLG(2), MME(8), MS4A1(6), TFRC(6), THPO(11), TNF(1), TPO(18)	28071506	543	88	528	183	159	203	72	27	76	6	0.065	0.29
141	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	71	ABL1(9), ACTN1(13), ACTR2(7), ACTR3(3), AKT1(8), AKT2(4), AKT3(8), ANGPTL2(9), ARHGEF6(19), ARHGEF7(13), BRAF(12), CDC42(5), CDKN2A(1), CRK(1), CSE1L(15), DOCK1(32), EPHB2(10), FYN(7), GRB2(3), GRB7(3), ILK(8), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGB3BP(2), MAP2K4(6), MAP3K11(5), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7), MRAS(3), MYLK(17), MYLK2(7), P4HB(1), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PIK3CB(19), PKLR(10), PLCG1(12), PLCG2(27), PTK2(11), RAF1(7), RALA(4), RHO(8), ROCK1(27), ROCK2(15), SHC1(11), SOS1(21), SOS2(22), SRC(2), TERF2IP(4), TLN1(28), TLN2(29), VASP(2), ZYX(12)	39944070	719	98	689	197	184	275	97	35	120	8	0.066	0.29
142	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	11	AKT1(8), CREB1(5), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAPK1(2), MAPK14(6), MAPK3(4), NFKB1(12), RELA(6), SP1(6)	3780263	68	34	65	16	5	36	15	6	6	0	0.066	0.29
143	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(3), ALOX12(6), ALOX12B(10), ALOX15(12), ALOX15B(12), ALOX5(7), CBR1(2), CBR3(2), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2J2(5), CYP2U1(2), CYP4A11(5), CYP4A22(8), CYP4F2(11), CYP4F3(8), EPHX2(7), GGT1(10), GPX3(4), GPX5(7), GPX6(6), GPX7(1), LTA4H(6), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PTGDS(6), PTGES(2), PTGES2(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6)	12931334	248	63	242	75	67	103	34	13	29	2	0.070	0.30
144	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(4), FDFT1(3), FDPS(7), HMGCR(15), HMGCS1(4), IDI1(4), MVD(3), MVK(7), NSDHL(9), PMVK(2), SC4MOL(3), SC5DL(3), SQLE(6)	4147606	74	36	73	29	19	22	12	7	14	0	0.070	0.30
145	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(10), EGF(24), EGFR(20), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(4), PTPRB(31), RAF1(7), SHC1(11), SOS1(21), SPRY1(4), SPRY2(6), SPRY4(2), SRC(2)	8068879	149	50	146	40	39	59	26	8	15	2	0.072	0.31
146	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(6), ALOX15(12), ALOX5(7), CBR1(2), CBR3(2), CYP4F2(11), CYP4F3(8), EPX(14), GGT1(10), LPO(6), LTA4H(6), MPO(9), PLA2G1B(1), PLA2G2E(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), PTGDS(6), PTGES2(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6), TPO(18)	9229941	189	55	185	61	55	83	26	7	18	0	0.073	0.31
147	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	19	ABL1(9), ATR(38), CCNA1(4), CDC25A(9), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN1B(5), CDKN2A(1), DHFR(3), GSK3B(11), HDAC1(4), SKP2(6), TGFB1(4), TGFB2(6), TGFB3(9)	6939365	122	43	121	36	19	57	16	5	21	4	0.073	0.31
148	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	42	ACOX1(4), APOA2(2), CD36(7), CITED2(1), CREBBP(37), DUSP1(2), DUT(1), EHHADH(9), EP300(29), FABP1(5), HSD17B4(10), JUN(1), LPL(11), MAPK1(2), MAPK3(4), ME1(10), MRPL11(1), MYC(7), NCOA1(17), NCOR1(24), NCOR2(24), NFKBIA(3), NR0B2(2), NR1H3(5), NR2F1(5), NRIP1(18), PPARA(2), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PTGS2(7), RELA(6), RXRA(1), SP1(6), SRA1(3), STAT5A(5), STAT5B(5), TNF(1)	18478524	308	68	301	95	72	124	44	19	47	2	0.074	0.31
149	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(11), MAP3K14(12), MAPK14(6), MAPK8(7), NFKB1(12), RELA(6), TNFRSF13B(4), TNFRSF17(2), TNFSF13B(3), TRAF2(5), TRAF3(6), TRAF5(8), TRAF6(4)	4964508	86	39	85	19	18	33	14	4	17	0	0.079	0.32
150	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX15(12), ALOX5(7), CYP1A2(6), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2J2(5), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	8182643	153	51	150	44	37	60	25	8	23	0	0.079	0.32
151	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(7), CDO1(4), CSAD(10), GAD1(8), GAD2(12), GGT1(10)	2029827	51	28	50	9	15	13	16	1	6	0	0.080	0.33
152	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	78	ATF2(6), BRAF(12), CHUK(11), CREB1(5), DAXX(11), ELK1(2), FOS(6), GRB2(3), IKBKB(15), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K5(2), MAP2K6(9), MAP3K10(7), MAP3K11(5), MAP3K12(8), MAP3K13(13), MAP3K14(12), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K6(7), MAP3K7(8), MAP3K8(12), MAP3K9(6), MAP4K1(13), MAP4K2(6), MAP4K3(21), MAP4K4(14), MAP4K5(7), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK4(6), MAPK6(11), MAPK7(17), MAPK8(7), MAPK9(7), MAPKAPK2(6), MAPKAPK3(4), MAPKAPK5(6), MAX(8), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MKNK1(6), MKNK2(4), MYC(7), NFKB1(12), NFKBIA(3), PAK1(3), PAK2(6), RAF1(7), RELA(6), RIPK1(8), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KA5(7), RPS6KB1(3), RPS6KB2(6), SHC1(11), SP1(6), STAT1(14), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TRAF2(5)	30941418	604	93	590	148	139	256	82	35	88	4	0.081	0.33
153	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(4), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD58(1), CD8A(3), CSF3(1), IL6(2), IL8(3), KITLG(2)	2198083	35	23	35	8	6	18	3	0	8	0	0.084	0.34
154	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	21	ADRB1(2), AKT1(8), ASAH1(9), CAMP(1), DAG1(7), DLG4(13), EPHB2(10), GNAI1(4), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), PTX3(2), RHO(8), RYR1(80)	14019262	263	66	249	104	80	121	32	6	22	2	0.086	0.34
155	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(24), C5(20), C6(23), C7(21), C8A(12)	3912669	100	36	95	21	22	40	16	5	13	4	0.086	0.34
156	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	60	APAF1(19), BAD(2), BAK1(4), BAX(4), BCL2L1(3), BCL2L11(4), BID(3), BIRC2(13), BIRC3(3), BIRC5(4), BNIP3L(2), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP9(3), CHUK(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), GZMB(2), HELLS(14), IKBKB(15), IRF1(2), IRF2(6), IRF3(6), IRF4(6), IRF5(3), IRF6(9), JUN(1), LTA(3), MAP2K4(6), MAPK10(9), MDM2(6), MYC(7), NFKB1(12), NFKBIA(3), NFKBIB(3), NFKBIE(6), PLEKHG5(5), PRF1(8), RELA(6), RIPK1(8), TNF(1), TNFRSF10B(5), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(1), TNFSF10(1), TRAF1(5), TRAF2(5), TRAF3(6)	17281373	324	68	317	100	75	129	46	19	53	2	0.088	0.35
157	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(12), GAD1(8), HDC(10), PNMT(3), TPH1(14)	1856313	47	27	46	7	12	18	9	1	5	2	0.089	0.35
158	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(8), ARSB(6), ARSD(9), ARSE(7), CYP11B1(6), CYP11B2(7), HSD11B1(4), HSD17B2(3), HSD17B3(6), HSD17B8(2), HSD3B1(1), HSD3B2(5), SRD5A1(4), SRD5A2(4), STS(9), SULT1E1(13), SULT2A1(7), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10)	9296383	176	53	167	51	50	70	22	14	20	0	0.091	0.35
159	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(7), HSD3B7(3), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	1650056	31	23	31	8	10	15	3	1	2	0	0.092	0.36
160	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(10), AARS2(13), ABAT(9), ACY3(4), ADSL(7), ADSS(8), ADSSL1(6), AGXT(5), AGXT2(9), ASL(4), ASNS(9), ASPA(5), ASRGL1(2), ASS1(3), CAD(38), CRAT(3), DARS(4), DARS2(7), DDO(9), DLAT(2), DLD(7), GAD1(8), GAD2(12), GOT1(6), GOT2(5), GPT2(7), NARS(7), NARS2(7), PC(8), PDHA1(4), PDHA2(10), PDHB(7)	12629716	245	64	241	82	60	102	37	10	36	0	0.092	0.36
161	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(4), BIRC2(13), BIRC3(3), CASP3(4), CFLAR(7), FADD(1), JUN(1), MAP2K4(6), MAP3K3(9), MAP3K7(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), NR2C2(8), RALBP1(7), RIPK1(8), TNF(1), TNFAIP3(2), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	8563131	132	50	129	33	29	58	21	6	18	0	0.093	0.36
162	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(12), AGXT(5), AGXT2(9), AKR1B10(4), ALAS1(12), ALAS2(11), AMT(5), AOC2(6), AOC3(14), BHMT(2), CBS(13), CHDH(5), CHKA(8), CTH(5), DAO(5), DLD(7), DMGDH(6), GARS(8), GATM(8), GLDC(20), GNMT(3), HSD3B7(3), MAOA(14), MAOB(7), PEMT(2), PHGDH(7), PIPOX(6), PISD(5), PSAT1(5), PSPH(1), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SARDH(9), SARS(4), SARS2(7), SDS(3), SHMT1(6), SHMT2(8), TARS(10), TARS2(10)	14500847	292	61	284	87	80	123	40	12	35	2	0.097	0.37
163	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCL4(1), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR7(5), CD28(6), CD4(8), CXCR3(5), CXCR4(1), IFNG(5), IFNGR1(6), IFNGR2(4), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18R1(5), IL2(4), IL4R(6), IL5(2), TGFB1(4), TGFB2(6), TGFB3(9)	6817236	136	47	134	45	27	63	15	8	23	0	0.098	0.37
164	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATR(38), BRCA1(19), CCNB1(8), CDC25A(9), CDC25B(3), CDC25C(8), CDKN1A(1), CDKN2D(3), CHEK1(4), CHEK2(14), EP300(29), MDM2(6), PRKDC(70), RPS6KA1(5), WEE1(1), YWHAH(4), YWHAQ(3)	12550846	225	55	217	37	34	79	39	19	49	5	0.099	0.37
165	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(4), DCN(11), FMOD(5), KERA(8), LUM(12)	1308286	40	21	37	12	12	14	3	2	9	0	0.10	0.37
166	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(4), B4GALT7(4), CHPF(5), CHST11(9), CHST12(5), CHST14(2), CHST3(4), CHST7(4), CHSY1(1), DSE(17), UST(4), XYLT1(15), XYLT2(9)	4638512	88	36	86	40	24	39	15	2	8	0	0.10	0.37
167	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	IL6(2), IL6R(12), JAK2(21), JAK3(9), PIAS3(9), PTPRU(20), REG1A(4), SRC(2), STAT3(12)	4410984	91	36	89	24	20	37	13	3	12	6	0.10	0.38
168	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(9), BUB1(9), BUB1B(6), BUB3(5), CCNA1(4), CCNA2(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND2(7), CCND3(5), CCNE2(6), CCNH(3), CDAN1(12), CDC14A(8), CDC14B(6), CDC20(5), CDC25A(9), CDC25B(3), CDC25C(8), CDC6(3), CDC7(13), CDH1(15), CDK2(5), CDK4(4), CDKN1A(1), CDKN2A(1), CHEK1(4), CHEK2(14), DTX4(7), E2F2(1), E2F3(5), E2F4(3), E2F5(1), E2F6(3), EP300(29), ESPL1(10), GSK3B(11), HDAC1(4), HDAC2(5), HDAC3(10), HDAC4(18), HDAC5(15), HDAC6(22), HDAC8(3), MAD1L1(15), MAD2L1(5), MAD2L2(3), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), MPEG1(13), MPL(5), PCNA(3), PLK1(6), PRKDC(70), PTPRA(11), PTTG1(5), PTTG2(1), RBL1(17), SKP2(6), SMAD4(5), TBC1D8(12), TGFB1(4), WEE1(1)	35572760	589	93	570	153	134	269	70	25	82	9	0.10	0.38
169	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(2), ACP5(4), ACPP(5), ACPT(7), ENPP1(11), ENPP3(16), FLAD1(8), RFK(2), TYR(10)	3401209	69	32	69	20	17	26	15	6	5	0	0.10	0.38
170	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(8), BAD(2), BCL2L1(3), CASP9(3), CDC42(5), CHUK(11), ELK1(2), H2AFX(1), MAP2K1(2), MAPK3(4), NFKB1(12), RAF1(7), RALA(4), RALBP1(7), RALGDS(10), RELA(6), RHOA(4)	5158815	91	38	86	16	18	42	16	4	11	0	0.11	0.38
171	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	18	BAD(2), BAX(4), CYCS(3), FADD(1), MAP2K1(2), MAP2K4(6), MAPK1(2), MAPK3(4), MAPK8(7), NFKB1(12), NSMAF(11), RAF1(7), RELA(6), RIPK1(8), SMPD1(12), TNFRSF1A(6), TRAF2(5)	5621519	98	41	97	18	17	36	22	5	18	0	0.11	0.38
172	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	29	CHUK(11), IFNB1(4), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(5), IRAK2(7), IRAK3(13), JUN(1), MAP2K3(8), MAP2K6(9), MAP3K14(12), MAP3K7(8), MAPK14(6), MAPK8(7), MYD88(1), NFKB1(12), NFKBIA(3), RELA(6), TGFB1(4), TGFB2(6), TGFB3(9), TNF(1), TRAF6(4)	9072918	165	49	161	43	31	77	28	9	20	0	0.11	0.38
173	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2)	3981262	77	35	76	25	19	31	7	6	14	0	0.11	0.38
174	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(4), ACTA2(7), ACTN2(9), ACTN3(10), ACTN4(11), DES(5), DMD(83), FAM48A(7), MYBPC1(20), MYBPC2(9), MYBPC3(14), MYH3(30), MYH6(23), MYH7(28), MYH8(35), MYL1(7), MYL2(1), MYL4(1), MYL9(3), MYOM1(34), NEB(127), TMOD1(2), TNNC2(4), TNNI1(1), TNNI3(5), TNNT1(5), TNNT2(8), TPM1(2), TPM2(1), TPM3(6), TPM4(6), TTN(652), VIM(8)	49100638	1168	105	1133	243	337	414	192	62	64	99	0.11	0.40
175	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	21	CSNK2A1(9), EGF(24), EGFR(20), ELK1(2), FOS(6), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(6), MAPK3(4), MAPK8(7), PLCG1(12), PRKCA(10), RAF1(7), SHC1(11), SOS1(21), SRF(3), STAT1(14), STAT3(12), STAT5A(5)	9237350	179	52	172	46	52	68	26	10	21	2	0.11	0.40
176	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(17), ADCY8(16), ARAF(8), ATF4(4), BRAF(12), CACNA1C(30), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CREBBP(37), EP300(29), GRIA1(12), GRIA2(25), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), GRM1(22), GRM5(22), ITPR1(31), ITPR2(38), ITPR3(23), MAP2K1(2), MAPK1(2), MAPK3(4), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PPP1R1A(4), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF3(11), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15)	34475033	646	92	629	214	156	258	115	25	90	2	0.12	0.41
177	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(1), ACTR2(7), ACTR3(3), AKT1(8), ANGPTL2(9), CDC42(5), CFL1(1), CFL2(8), FLNA(31), FLNC(34), FSCN1(2), FSCN3(5), GDI1(4), GDI2(3), LIMK1(7), MYH2(37), MYLK(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PFN1(1), PFN2(3), RHO(8), ROCK1(27), ROCK2(15), RPS4X(4), VASP(2), WASF1(3), WASL(8)	16003679	300	66	292	84	89	121	33	10	45	2	0.12	0.41
178	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(10), CARS2(1), CDO1(4), CTH(5), GOT1(6), GOT2(5), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), SDS(3), SULT1B1(4), SULT1C2(7), SULT1C4(4), SULT4A1(3)	4208312	73	37	68	35	20	23	10	6	14	0	0.12	0.41
179	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(3), FDPS(7), HMGCR(15), IDI1(4), MVD(3), MVK(7), NQO1(3), NQO2(4), PMVK(2), SC5DL(3), SQLE(6), VKORC1(3)	3405750	64	32	62	27	13	24	9	7	11	0	0.12	0.42
180	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(11), NR3C1(13), PPARG(5), RETN(2), RXRA(1), TNF(1)	1975096	37	23	35	10	13	12	2	2	8	0	0.12	0.42
181	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	115	ABL1(9), ABLIM1(8), ABLIM2(5), ABLIM3(9), ARHGEF12(25), CDC42(5), CDK5(1), CFL1(1), CFL2(8), CXCL12(3), CXCR4(1), DPYSL2(11), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA4(3), EFNA5(1), EFNB1(7), EFNB3(2), EPHA1(14), EPHA2(5), EPHA3(14), EPHA4(17), EPHA6(21), EPHA7(9), EPHA8(12), EPHB1(25), EPHB2(10), EPHB3(6), EPHB4(4), EPHB6(10), FES(16), FYN(7), GNAI1(4), GNAI2(7), GNAI3(3), GSK3B(11), ITGB1(12), L1CAM(16), LIMK1(7), LRRC4C(9), MAPK1(2), MAPK3(4), MET(10), NCK1(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NGEF(13), NRP1(16), NTN1(4), NTN4(5), NTNG1(11), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PLXNA1(22), PLXNA2(29), PLXNA3(19), PLXNB1(12), PLXNC1(29), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PTK2(11), RAC2(2), RGS3(15), RHOA(4), RHOD(3), RND1(7), ROBO1(25), ROBO2(27), ROBO3(16), ROCK1(27), ROCK2(15), SEMA3A(10), SEMA3B(8), SEMA3C(10), SEMA3D(9), SEMA3E(8), SEMA3F(6), SEMA3G(5), SEMA4A(7), SEMA4B(5), SEMA4C(8), SEMA4D(12), SEMA4F(15), SEMA4G(10), SEMA5A(19), SEMA5B(13), SEMA6A(13), SEMA6C(7), SEMA6D(23), SEMA7A(11), SLIT1(11), SLIT2(30), SLIT3(21), SRGAP1(21), SRGAP2(18), SRGAP3(13), UNC5B(9), UNC5C(8), UNC5D(14)	60562600	1138	110	1103	373	312	436	165	50	165	10	0.12	0.42
182	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(2), C1GALT1(4), C1GALT1C1(5), GALNT1(8), GALNT10(5), GALNT11(14), GALNT12(2), GALNT14(11), GALNT2(8), GALNT3(10), GALNT4(8), GALNT5(7), GALNT6(2), GALNT7(11), GALNT8(13), GALNTL1(12), GALNTL2(13), GALNTL4(6), GALNTL5(10), GCNT1(8), GCNT3(7), GCNT4(1), OGT(19), ST3GAL1(2), ST3GAL2(4), ST6GALNAC1(4), WBSCR17(14)	10764560	210	59	202	68	51	84	38	12	25	0	0.13	0.42
183	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(7), IFNG(5), IFNGR1(6), IFNGR2(4), IKBKB(15), JAK2(21), LIN7A(8), NFKB1(12), NFKBIA(3), RELA(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), USH1C(10), WT1(3)	5231471	110	39	108	38	18	40	24	6	16	6	0.13	0.42
184	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(28), ABCB11(18), ABCB4(29), ABCC1(23), ABCC3(14), GSTP1(2)	5203986	114	39	110	39	39	34	12	7	20	2	0.13	0.43
185	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(7), AGTR2(8), CALM2(3), CALM3(1), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CDK5(1), F2(9), FYN(7), GNA11(3), GNAI1(4), GNB1(3), GRB2(3), JAK2(21), MAP2K1(2), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPT(11), MYLK(17), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), STAT1(14), STAT3(12), STAT5A(5), SYT1(4)	14175090	256	65	248	73	66	103	35	13	31	8	0.13	0.43
186	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(9), ENO1(5), GPI(9), HK1(13), PGAM1(2), PGK1(6), PKLR(10), TPI1(1)	2575703	55	27	53	14	16	22	4	3	8	2	0.13	0.43
187	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(8), CNR2(3), DNMT1(15), MTNR1A(6), MTNR1B(4), PTAFR(6), PTGDR(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3)	3471953	74	36	70	28	18	36	12	4	4	0	0.13	0.43
188	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), ESRRA(2), HDAC5(15), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), PPARA(2), PPP3CA(4), PPP3CB(7), PPP3CC(6), SLC2A4(4), SYT1(4), YWHAH(4)	6774216	122	42	120	37	28	52	16	4	22	0	0.13	0.43
189	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(4), FUCA1(3), FUCA2(3), GLB1(9), HEXA(3), HEXB(4), LCT(30), MAN2B1(20), MAN2B2(9), MAN2C1(8), MANBA(14), NEU2(5), NEU3(3)	6820343	115	47	112	33	32	51	15	6	11	0	0.13	0.43
190	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	CHUK(11), DAXX(11), EGF(24), EGFR(20), ETS1(6), ETS2(5), FOS(6), HOXA7(8), IKBKB(15), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K14(12), MAP3K5(21), MAPK1(2), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), NFKB1(12), NFKBIA(3), PPP2CA(6), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), RAF1(7), RELA(6), RIPK1(8), SP1(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	15697520	309	64	304	92	70	131	54	17	37	0	0.14	0.44
191	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	26	ACVR1(9), ATF2(6), AXIN1(8), BMP10(6), BMP2(5), BMP4(7), BMPR1A(8), BMPR2(14), CHRD(14), FZD1(2), GATA4(1), GSK3B(11), MAP3K7(8), MEF2C(11), MYL2(1), NOG(1), NPPA(1), NPPB(2), RFC1(15), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TGFBR3(8), WNT1(1)	8726368	172	52	169	37	45	78	27	6	16	0	0.14	0.44
192	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(32), GNA12(10), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAR2A(4), PRKAR2B(5)	3482708	61	34	58	17	12	29	5	4	11	0	0.14	0.44
193	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	8	ADAM17(11), AXIN1(8), BTRC(13), DLL1(8), FZD1(2), GSK3B(11), PSEN1(4), WNT1(1)	2823546	58	28	57	25	13	30	6	3	6	0	0.14	0.46
194	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(12), AGXT(5), AGXT2(9), ALAS1(12), ALAS2(11), AMT(5), AOC2(6), AOC3(14), ATP6V0C(2), BHMT(2), CBS(13), CHDH(5), CHKA(8), CTH(5), DAO(5), DLD(7), DMGDH(6), GARS(8), GATM(8), GLDC(20), MAOA(14), MAOB(7), PEMT(2), PISD(5), PLCB2(9), PLCG1(12), PLCG2(27), PSPH(1), SARDH(9), SARS(4), SHMT1(6), SHMT2(8), TARS(10)	14110560	277	61	268	77	75	111	37	15	37	2	0.14	0.46
195	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(12), CPEB1(10), EGFR(20), ERBB2(6), ERBB4(29), ETS1(6), ETS2(5), ETV6(9), ETV7(4), FMN2(22), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(4), NOTCH2(17), NOTCH3(31), NOTCH4(15), PIWIL1(17), PIWIL2(16), PIWIL3(7), PIWIL4(13), RAF1(7), SOS1(21), SOS2(22), SPIRE1(9)	16034510	309	70	299	55	67	136	49	18	33	6	0.15	0.46
196	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(5), HK1(13), HK2(8), HK3(12), IMPA1(4), IMPA2(6), PGM1(9), PGM3(6), TGDS(3)	3699003	66	32	64	25	20	24	9	5	8	0	0.15	0.47
197	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(9), ELK1(2), EPO(2), EPOR(4), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PLCG1(12), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5)	7451064	122	44	116	24	34	42	15	9	14	8	0.15	0.47
198	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(5), APEX1(3), CREBBP(37), DFFA(1), DFFB(3), GZMA(6), GZMB(2), HMGB2(3), PRF1(8), SET(6)	3605076	74	33	72	23	18	29	7	5	15	0	0.15	0.47
199	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(9), BCAT2(6), COASY(11), DPYD(16), DPYS(3), ENPP1(11), ENPP3(16), ILVBL(7), PANK1(3), PANK2(8), PANK3(7), PANK4(8), PPCDC(1), PPCS(4), UPB1(9), VNN1(7)	5766114	126	42	124	32	32	48	20	6	20	0	0.16	0.48
200	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(8), CYP11A1(10), CYP11B1(6), CYP11B2(7), CYP17A1(3), CYP21A2(7), HSD11B1(4), HSD3B1(1), HSD3B2(5)	3168901	56	29	55	21	8	30	7	3	8	0	0.16	0.48
201	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(8), CYP11A1(10), CYP11B1(6), CYP11B2(7), CYP17A1(3), CYP21A2(7), HSD11B1(4), HSD3B1(1), HSD3B2(5)	3168901	56	29	55	21	8	30	7	3	8	0	0.16	0.48
202	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(6), CD4(8), HLA-DRB1(1)	866136	15	11	15	5	2	9	0	0	4	0	0.16	0.48
203	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(24), EGFR(20), ERBB3(16), NRG1(25)	3597189	85	35	82	17	23	36	13	6	7	0	0.16	0.48
204	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(6), CD3D(3), CD3E(2), CD3G(2), IFNG(5), IL2(4), IL2RA(3), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TGFBR3(8), TOB1(2), TOB2(6)	3716928	74	33	74	25	16	33	11	6	8	0	0.16	0.48
205	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(30), APOC1(1), APOE(1), CETP(6), CYP7A1(12), HMGCR(15), LCAT(2), LDLR(12), LIPC(8), LPL(11), LRP1(53), SCARB1(8), SOAT1(10)	8783728	169	54	166	43	53	67	26	8	15	0	0.16	0.49
206	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(8), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6)	3392127	52	31	52	22	10	23	7	3	9	0	0.16	0.49
207	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ABP1(12), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), AOX1(19), DBH(12), DCT(15), DDC(11), FAH(7), GOT1(6), GOT2(5), GSTZ1(4), HPD(7), MAOA(14), MAOB(7), PNMT(3), TAT(9), TPO(18), TYR(10)	10362323	240	53	232	56	63	96	38	13	30	0	0.17	0.49
208	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(14), COPS5(6), CREB1(5), EDN1(2), EP300(29), EPO(2), HIF1A(17), JUN(1), LDHA(6), NOS3(11), P4HB(1), VHL(2)	5601682	103	37	102	17	27	33	20	4	19	0	0.17	0.49
209	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	CBL(10), CD28(6), CD3D(3), CSK(1), CTLA4(2), DAG1(7), EPHB2(10), GRAP2(3), GRB2(3), ITK(10), ITPKB(6), LCK(5), LCP2(7), MAPK1(2), NCK1(4), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PLCG1(12), PTPRC(15), RAF1(7), RASGRP1(8), RASGRP2(5), RASGRP3(8), RASGRP4(7), SOS1(21), SOS2(22), VAV1(16), ZAP70(10)	18196743	299	68	288	107	83	116	37	13	44	6	0.17	0.49
210	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(11), CALM2(3), CALM3(1), ELK1(2), FCER1A(6), FCER1G(1), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAP2K4(6), MAPK1(2), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), PAK2(6), PLA2G4A(11), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), RAF1(7), SHC1(11), SOS1(21), SYK(6), SYT1(4), VAV1(16)	12183025	208	59	202	61	65	74	28	9	28	4	0.17	0.49
211	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	16	ABL1(9), BRCA1(19), CDKN1A(1), CHEK1(4), CHEK2(14), JUN(1), MAPK8(7), MDM2(6), MRE11A(12), NFKB1(12), NFKBIA(3), RAD50(19), RAD51(4), RBBP8(10), RELA(6)	7665925	127	47	123	30	15	53	21	10	26	2	0.17	0.49
212	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(3), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADK(1), ADSL(7), ADSS(8), ADSSL1(6), AK1(2), AK2(4), AK5(6), AK7(15), ALLC(10), AMPD1(21), AMPD2(9), AMPD3(4), ATIC(9), CANT1(5), DCK(4), DGUOK(3), ENPP1(11), ENPP3(16), ENTPD1(6), ENTPD3(8), ENTPD4(4), ENTPD5(2), ENTPD6(15), FHIT(2), GART(8), GDA(5), GMPR(7), GMPR2(4), GMPS(13), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(10), ITPA(1), NME6(2), NME7(4), NPR1(14), NPR2(16), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT2(3), NUDT5(1), NUDT9(1), PAICS(4), PAPSS1(6), PAPSS2(6), PDE10A(14), PDE11A(12), PDE1A(12), PDE1C(14), PDE2A(14), PDE3B(15), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE5A(14), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(7), PDE8B(20), PDE9A(10), PFAS(10), PKLR(10), PKM2(5), PNPT1(9), POLA1(26), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), PPAT(10), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(5), PRPS2(10), PRUNE(4), RFC5(7), RRM1(4), RRM2(5), RRM2B(5), XDH(10), ZNRD1(1)	55894213	1005	106	983	294	269	415	137	59	121	4	0.17	0.49
213	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	15	CSF1(5), CSF1R(7), DDX20(6), E2F4(3), ETS1(6), ETS2(5), FOS(6), HDAC2(5), HDAC5(15), JUN(1), NCOR2(24), RBL1(17), RBL2(21), SIN3B(15)	6781625	136	45	130	37	37	60	13	8	15	3	0.17	0.49
214	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(9), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAPK3(4), MPL(5), PLCG1(12), PRKCA(10), RAF1(7), SHC1(11), SOS1(21), STAT1(14), STAT3(12), STAT5A(5), STAT5B(5), THPO(11)	8464663	159	48	152	38	41	60	24	10	16	8	0.18	0.50
215	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	102	A4GNT(6), ALG1(2), ALG10(9), ALG10B(8), ALG11(6), ALG12(1), ALG13(17), ALG14(2), ALG2(2), ALG3(5), ALG6(5), ALG8(8), ALG9(6), B3GNT1(7), B3GNT2(4), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), B4GALT5(2), B4GALT7(4), C1GALT1(4), C1GALT1C1(5), CHPF(5), CHST1(10), CHST11(9), CHST12(5), CHST14(2), CHST2(5), CHST3(4), CHST4(6), CHST7(4), CHSY1(1), DAD1(1), DDOST(3), DPAGT1(4), EXT1(12), EXT2(8), EXTL1(13), EXTL2(10), EXTL3(10), FUT11(2), FUT8(13), GALNT1(8), GALNT10(5), GALNT11(14), GALNT12(2), GALNT14(11), GALNT2(8), GALNT3(10), GALNT4(8), GALNT5(7), GALNT6(2), GALNT7(11), GALNT8(13), GALNTL1(12), GALNTL2(13), GALNTL4(6), GALNTL5(10), GANAB(13), GCNT1(8), GCNT3(7), GCNT4(1), HS2ST1(5), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), HS3ST5(10), HS6ST2(11), HS6ST3(2), MAN1A1(11), MAN1A2(9), MAN1B1(4), MAN1C1(7), MAN2A1(23), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), MGAT5B(7), NDST1(13), NDST2(7), NDST3(17), NDST4(11), OGT(19), RPN1(6), RPN2(9), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4), ST6GAL1(10), ST6GALNAC1(4), STT3B(6), UST(4), WBSCR17(14), XYLT1(15), XYLT2(9)	36647782	710	94	680	224	180	295	114	31	84	6	0.18	0.50
216	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	54	APAF1(19), ATR(38), BAI1(8), BAX(4), BID(3), CASP3(4), CASP9(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND2(7), CCND3(5), CCNE2(6), CCNG1(6), CCNG2(4), CD82(2), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(4), CHEK2(14), CYCS(3), DDB2(5), EI24(7), FAS(7), GTSE1(2), IGF1(3), IGFBP3(7), MDM2(6), MDM4(1), PERP(3), PMAIP1(1), RCHY1(5), RFWD2(6), RRM2(5), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(7), SESN2(3), SESN3(14), SIAH1(3), STEAP3(5), THBS1(12), TNFRSF10B(5), TP53I3(5), TSC2(14), ZMAT3(10)	16979755	323	72	317	96	60	137	46	25	49	6	0.18	0.50
217	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(19), BAK1(4), BAX(4), BCL2L1(3), BID(3), BIRC2(13), BIRC3(3), CASP2(9), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CYCS(3), FADD(1), FAS(7), FASLG(6), GZMB(2), JUN(1), MAP2K4(6), MAP3K14(12), MAPK10(9), MCL1(1), MDM2(6), MYC(7), NFKB1(12), NFKBIA(3), PARP1(11), PRF1(8), RELA(6), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(1), TRAF1(5), TRAF2(5)	11030567	203	56	199	61	45	80	36	15	25	2	0.18	0.51
218	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	45	APAF1(19), ARHGDIB(2), BAG4(4), BID(3), BIRC2(13), BIRC3(3), CASP2(9), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CFLAR(7), CHUK(11), CRADD(3), CYCS(3), DAXX(11), DFFA(1), DFFB(3), FADD(1), GSN(5), LMNA(8), LMNB1(5), MAP3K14(12), MAP3K5(21), MAPK8(7), MDM2(6), NFKB1(12), NFKBIA(3), NUMA1(28), PAK2(6), PRKCD(7), PRKDC(70), PSEN1(4), PSEN2(5), PTK2(11), RELA(6), RIPK1(8), SPTAN1(29), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF1(5), TRAF2(5)	21113499	381	69	374	98	92	159	52	25	50	3	0.18	0.51
219	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(8), EGFR(20), IGF1R(13), MYC(7), POLR2A(25), PPP2CA(6), PRKCA(10), TEP1(19), TERF1(2), TERT(6), TNKS(20), XRCC5(7)	8698405	143	45	136	56	34	67	17	7	18	0	0.18	0.51
220	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM2(3), CALM3(1), CD3D(3), CD3E(2), CD3G(2), ELK1(2), FOS(6), FYN(7), GRB2(3), JUN(1), LCK(5), MAP2K1(2), MAP2K4(6), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), PTPN7(5), RAF1(7), RELA(6), SHC1(11), SOS1(21), SYT1(4), VAV1(16), ZAP70(10)	13383283	223	62	217	65	62	85	30	11	31	4	0.18	0.51
221	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(8), GALNT10(5), GALNT2(8), GALNT3(10), GALNT4(8), GALNT6(2), GALNT7(11), GALNT8(13), GCNT1(8), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), WBSCR17(14)	4989603	97	40	95	30	24	38	20	7	8	0	0.18	0.51
222	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(12), EXT2(8), EXTL1(13), EXTL2(10), EXTL3(10), GLCE(5), HS2ST1(5), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), HS3ST5(10), HS6ST2(11), HS6ST3(2), NDST1(13), NDST2(7), NDST3(17), NDST4(11)	6906144	146	47	143	48	36	60	21	8	19	2	0.19	0.52
223	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(5), ICAM1(3), ITGAL(13), ITGB2(14), PRF1(8)	2865849	54	30	52	22	13	30	6	0	5	0	0.19	0.52
224	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(9), ALDH4A1(2), ALDH5A1(9), CAD(38), CPS1(24), EPRS(11), GAD1(8), GAD2(12), GCLC(8), GCLM(3), GFPT1(11), GLS(10), GLS2(9), GLUD1(4), GLUL(6), GMPS(13), GOT1(6), GOT2(5), GPT2(7), GSS(5), NADSYN1(12), PPAT(10), QARS(6)	11208144	228	58	221	60	48	99	36	10	31	4	0.19	0.52
225	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNG(5), IFNGR1(6), IFNGR2(4), JAK2(21), STAT1(14)	2086709	50	25	48	14	11	15	10	2	6	6	0.19	0.52
226	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(9), CAMK1G(5), HDAC9(19), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MYOD1(3), YWHAH(4)	2814942	66	28	62	15	15	27	7	3	14	0	0.19	0.52
227	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	16	CHUK(11), DUSP1(2), IKBKAP(14), IKBKB(15), LTA(3), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFAIP3(2), TNFRSF1B(3), TRAF1(5), TRAF2(5), TRAF3(6)	6845199	111	41	110	32	19	51	15	8	18	0	0.19	0.53
228	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	62	A2M(21), BDKRB1(5), BDKRB2(9), C1QA(6), C1QB(3), C1QC(6), C1R(15), C1S(9), C2(6), C3(24), C3AR1(7), C4BPA(8), C4BPB(4), C5(20), C5AR1(5), C6(23), C7(21), C8A(12), C8B(4), CD46(1), CD55(6), CD59(2), CFB(8), CFH(17), CFI(9), CPB2(7), CR1(28), F10(10), F11(10), F12(3), F13A1(10), F13B(13), F2(9), F2R(8), F3(6), F5(46), F7(2), F8(41), F9(11), FGA(30), FGB(6), FGG(12), KLKB1(13), KNG1(8), MASP1(14), MASP2(6), MBL2(3), PLAT(6), PLAU(5), PLAUR(5), PLG(13), PROC(7), SERPINA1(4), SERPINA5(3), SERPINC1(9), SERPIND1(6), SERPINE1(5), SERPINF2(5), SERPING1(7), TFPI(11), VWF(31)	30119736	664	86	636	182	183	284	84	33	72	8	0.19	0.53
229	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(5), HK1(13), HK2(8), HK3(12), IMPA1(4), PGM1(9), PGM3(6), TGDS(3)	3521187	60	30	58	25	20	19	9	5	7	0	0.20	0.53
230	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	42	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCR(6), BLNK(4), BTK(11), CD19(7), CD22(13), CSK(1), DAG1(7), FLOT1(1), FLOT2(3), GRB2(3), GSK3A(9), GSK3B(11), INPP5D(14), ITPR1(31), ITPR2(38), ITPR3(23), LYN(7), MAP4K1(13), MAPK1(2), MAPK3(4), NFATC2(15), NR0B2(2), PDK1(7), PIK3CD(10), PLCG2(27), PPP1R13B(7), PPP3CA(4), PPP3CB(7), PPP3CC(6), PTPRC(15), RAF1(7), SHC1(11), SOS1(21), SOS2(22), SYK(6), VAV1(16)	23088595	413	80	400	146	114	170	61	16	44	8	0.20	0.53
231	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(11), FOS(6), GRB2(3), IL3RA(11), JAK2(21), MAP2K1(2), MAPK3(4), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5)	5983843	107	39	104	24	28	45	13	8	5	8	0.20	0.53
232	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	12	CREB1(5), CREM(5), FOS(6), JUN(1), MAPK3(4), OPRK1(9), POLR2A(25), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5)	4218350	76	36	74	21	16	38	7	5	10	0	0.20	0.53
233	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(2), ACP5(4), ACP6(3), ACPP(5), ACPT(7), ENPP1(11), ENPP3(16), FLAD1(8), LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), PHPT1(2), RFK(2), TYR(10)	5220238	104	38	102	34	23	38	22	7	14	0	0.20	0.53
234	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(6), CD4(8), CD80(7), HLA-DRB1(1), IL10(4), IL2(4)	1439736	30	17	30	11	5	15	5	0	5	0	0.20	0.53
235	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAD(3), ALAS1(12), ALAS2(11), CPO(4), FECH(5), GATA1(9), HBB(3), HMBS(7), UROD(2), UROS(3)	2819483	59	27	57	12	10	29	6	3	11	0	0.20	0.53
236	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12)	5766353	139	41	133	37	28	61	20	7	19	4	0.21	0.53
237	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), AKAP1(8), AKAP10(7), AKAP11(32), AKAP12(20), AKAP3(15), AKAP4(1), AKAP5(2), AKAP6(30), AKAP7(4), AKAP8(2), AKAP9(57), ARHGEF1(11), CALM2(3), CALM3(1), CHMP1B(3), GNA11(3), GNA12(10), GNA13(9), GNA14(5), GNA15(1), GNAI2(7), GNAI3(3), GNAL(6), GNAO1(5), GNAZ(7), GNB1(3), GNB2(5), GNB3(4), GNB5(3), GNG12(2), GNG13(2), GNG3(3), GNGT2(1), ITPR1(31), KCNJ3(15), PALM2(6), PDE1A(12), PDE1B(9), PDE1C(14), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE7A(3), PDE7B(4), PDE8A(7), PDE8B(20), PLCB3(9), PPP3CA(4), PPP3CC(6), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), PRKD1(8), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(10), USP5(13)	39738052	724	94	704	266	195	290	107	39	84	9	0.21	0.53
238	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(20), BMPR1A(8), BMPR1B(6), BMPR2(14)	2144786	48	26	47	8	14	18	9	2	5	0	0.21	0.54
239	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD8A(3), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15), THY1(1)	3648096	66	32	65	27	16	33	7	2	8	0	0.21	0.55
240	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	IFNG(5), IFNGR1(6), JAK2(21), PTPRU(20), REG1A(4), STAT1(14)	3153605	70	32	68	19	13	27	12	2	10	6	0.22	0.56
241	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(9), ADC(8), ALDH4A1(2), ALDH5A1(9), CAD(38), CPS1(24), EARS2(4), EPRS(11), GAD1(8), GAD2(12), GCLC(8), GCLM(3), GFPT1(11), GFPT2(12), GLS(10), GLS2(9), GLUD1(4), GLUD2(9), GLUL(6), GMPS(13), GNPNAT1(2), GOT1(6), GOT2(5), GPT2(7), GSR(5), GSS(5), NADSYN1(12), NAGK(3), PPAT(10), QARS(6)	13372528	271	62	264	78	60	122	39	10	36	4	0.22	0.56
242	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(25), FYN(7), ITGA1(20), ITGB1(12), L1CAM(16), LYN(7), RAP1B(2), SELP(15)	5669558	125	41	120	38	33	58	12	4	18	0	0.22	0.56
243	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	81	CD36(7), CD44(12), CD47(8), CHAD(3), COL11A1(36), COL11A2(13), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), DAG1(7), FN1(39), FNDC1(37), FNDC3A(9), FNDC4(4), FNDC5(1), GP1BA(11), GP5(5), GP6(3), HMMR(12), HSPG2(37), IBSP(6), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAV(10), ITGB1(12), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), RELN(48), SDC1(1), SDC2(2), SDC3(2), SDC4(8), SPP1(3), SV2A(17), SV2B(15), SV2C(16), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNC(19), TNN(16), TNR(16), TNXB(25), VWF(31)	73405265	1343	119	1316	398	353	551	174	68	166	31	0.22	0.56
244	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(9), COASY(11), DPYD(16), DPYS(3), ENPP1(11), ENPP3(16), PANK1(3), PANK2(8), PANK3(7), PANK4(8), PPCS(4), UPB1(9)	4559642	105	36	104	23	27	36	17	5	20	0	0.22	0.56
245	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	13	ATN1(9), BAIAP2(1), CASP1(7), CASP3(4), CASP7(4), GAPDH(2), INSR(18), ITCH(8), MAGI1(32), MAGI2(26), RERE(14), WWP1(18), WWP2(7)	7606175	150	46	148	40	32	77	20	6	15	0	0.22	0.56
246	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	CAD(38), CANT1(5), CDA(1), CTPS(10), CTPS2(10), DCK(4), DCTD(5), DHODH(3), DPYD(16), DPYS(3), DUT(1), ENTPD1(6), ITPA(1), NT5C(1), NT5E(6), NT5M(4), NUDT2(3), POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), RRM1(4), RRM2(5), TK1(2), TK2(7), TXNRD1(10), TYMS(1), UCK1(5), UCK2(6), UMPS(7), UNG(1), UPB1(9), UPP1(4)	19174731	319	71	312	92	64	138	43	23	51	0	0.22	0.56
247	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(5), TAT(9)	900313	20	14	19	3	5	7	3	3	2	0	0.23	0.56
248	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	88	CD2BP2(3), CDC40(8), CLK2(10), CLK3(5), CLK4(6), COL2A1(14), CPSF1(9), CPSF2(10), CPSF3(8), CPSF4(3), CSTF1(4), CSTF2(12), CSTF2T(8), CSTF3(12), DDIT3(1), DDX1(6), DDX20(6), DHX15(10), DHX16(16), DHX38(14), DHX8(10), DHX9(18), DICER1(39), DNAJC8(1), FUS(3), GIPC1(1), METTL3(8), NCBP1(9), NCBP2(4), NONO(15), NXF1(4), PABPN1(4), PAPOLA(10), PHF5A(1), POLR2A(25), PPM1G(7), PRPF18(4), PRPF3(11), PRPF4(6), PRPF4B(25), PRPF8(27), PSKH1(6), PTBP1(2), PTBP2(6), RBM17(9), RBM5(5), RNGTT(13), RNMT(7), RNPS1(1), SF3A1(9), SF3A3(6), SF3B1(18), SF3B2(10), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(3), SNRPB2(1), SNRPD1(1), SNRPD2(2), SNRPD3(2), SNRPE(2), SNRPG(1), SRPK1(14), SRPK2(7), SRRM1(10), SUPT5H(20), U2AF1(3), U2AF2(6), XRN2(14)	36040722	583	94	568	169	167	224	81	40	67	4	0.23	0.56
249	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), AGPS(10), ENPP2(20), ENPP6(9), PAFAH1B1(1), PAFAH1B2(3), PAFAH2(6), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLD1(16), PLD2(7), PPAP2A(4), PPAP2B(3)	7669749	138	46	135	42	33	56	17	7	23	2	0.23	0.56
250	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CSF1(5), IL6(2), LDLR(12), LPL(11)	1875911	36	22	35	9	13	14	3	1	5	0	0.23	0.56
251	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	8	ESR2(8), PDE1A(12), PDE1B(9), PLCB1(6), PLCB2(9), PRL(6), VIP(2)	3374202	52	31	51	22	18	20	7	2	5	0	0.23	0.56
252	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(12), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), DDC(11), EPX(14), ESCO1(11), ESCO2(6), GOT1(6), GOT2(5), HPD(7), LPO(6), MAOA(14), MAOB(7), MPO(9), NAT6(2), PNPLA3(6), PRDX6(2), SH3GLB1(8), TAT(9), TPO(18)	11884275	192	55	187	61	56	73	28	8	27	0	0.24	0.58
253	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(10), DARS(4), EPRS(11), FARS2(2), GARS(8), HARS(4), IARS(13), KARS(7), LARS(23), LARS2(9), MARS(12), MARS2(7), NARS(7), QARS(6), RARS(11), SARS(4), TARS(10), WARS(6), WARS2(5), YARS(8)	11301115	177	52	176	68	39	80	32	7	19	0	0.24	0.58
254	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	34	AKT1(8), ATF2(6), CDC42(5), DLD(7), DUSP10(7), DUSP4(1), GAB1(10), GCK(5), IL1R1(5), JUN(1), MAP2K4(6), MAP2K5(2), MAP3K10(7), MAP3K11(5), MAP3K12(8), MAP3K13(13), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K7(8), MAP3K9(6), MAPK10(9), MAPK7(17), MAPK8(7), MAPK9(7), MYEF2(6), NFATC3(12), NR2C2(8), PAPPA(32), SHC1(11), TRAF6(4), ZAK(12)	15751295	296	66	287	93	86	126	37	9	36	2	0.24	0.59
255	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	87	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADRB1(2), DRD1(6), DRD2(10), EGF(24), EGFR(20), GJA1(6), GJD2(8), GNA11(3), GNAI1(4), GNAI2(7), GNAI3(3), GNAS(25), GRB2(3), GRM1(22), GRM5(22), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), HTR2A(15), HTR2B(2), ITPR1(31), ITPR2(38), ITPR3(23), MAP2K1(2), MAP2K5(2), MAP3K2(8), MAPK1(2), MAPK3(4), MAPK7(17), NPR1(14), NPR2(16), PDGFB(4), PDGFC(4), PDGFD(6), PDGFRA(29), PDGFRB(12), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKG1(9), PRKG2(10), PRKX(4), RAF1(7), SOS1(21), SOS2(22), SRC(2), TJP1(33), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3)	44442050	878	98	856	271	238	363	130	38	99	10	0.25	0.59
256	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(7), B3GNT2(4), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), CHST1(10), CHST2(5), CHST4(6), FUT8(13), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4)	3844793	82	35	76	32	20	38	11	3	10	0	0.25	0.61
257	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(2), ACP5(4), ACP6(3), ACPP(5), ACPT(7), ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), CMBL(4), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), PON1(12), PON2(8), PON3(1)	6073229	122	41	119	36	33	42	25	8	14	0	0.26	0.62
258	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(27), ACACB(31), MCAT(3), OLAH(7), OXSM(6)	4227432	74	35	71	25	20	27	11	2	10	4	0.26	0.63
259	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(24), ARHGEF1(11), GNA12(10), GNA13(9), GNB1(3), MYL2(1), MYLK(17), PLCB1(6), PPP1R12B(18), PRKCA(10), ROCK1(27)	7293563	136	43	132	32	39	46	17	7	19	8	0.27	0.63
260	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	118	ARAF(8), BID(3), BRAF(12), CASP3(4), CD244(4), CD247(5), CD48(4), FAS(7), FASLG(6), FCER1G(1), FCGR3A(2), FCGR3B(5), FYN(7), GRB2(3), GZMB(2), HCST(2), HLA-A(5), HLA-B(3), HLA-E(2), HLA-G(3), ICAM1(3), ICAM2(5), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), ITGAL(13), ITGB2(14), KIR2DL1(6), KIR2DL3(2), KIR2DL4(3), KIR3DL1(7), KIR3DL2(7), KLRC1(2), KLRC2(3), KLRC3(1), KLRD1(2), KLRK1(1), LCK(5), LCP2(7), MAP2K1(2), MAPK1(2), MAPK3(4), MICB(3), NCR1(5), NCR2(5), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), PAK1(3), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRF1(8), PRKCA(10), PRKCG(10), PTK2B(16), PTPN11(8), RAC2(2), RAF1(7), SH2D1A(3), SH2D1B(2), SH3BP2(10), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SYK(6), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(1), VAV1(16), VAV2(5), VAV3(13), ZAP70(10)	36322264	668	95	653	211	189	264	91	36	80	8	0.27	0.63
261	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(8), AKT3(8), CAPN1(4), CAPN10(8), CAPN11(8), CAPN2(6), CAPN3(13), CAPN5(6), CAPN6(6), CAPN7(8), CAPN9(12), CAPNS1(3), CAV2(1), CDC42(5), CRK(1), CSK(1), DOCK1(32), FYN(7), GIT2(9), GRB2(3), ILK(8), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAD(11), ITGAE(14), ITGAL(13), ITGAM(24), ITGAV(10), ITGAX(9), ITGB1(12), ITGB2(14), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAPK10(9), MAPK4(6), MAPK6(11), MAPK7(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PDPK1(3), PIK3R2(4), PTK2(11), PXN(6), RAC2(2), RAP1B(2), RAPGEF1(18), RHO(8), ROCK1(27), ROCK2(15), SDCCAG8(14), SEPP1(4), SHC1(11), SHC3(9), SORBS1(22), SOS1(21), SRC(2), TLN1(28), TNS1(20), VASP(2), VAV2(5), VAV3(13), VCL(14), ZYX(12)	45473574	827	99	800	281	225	335	101	37	117	12	0.27	0.63
262	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(3), SLPI(3)	610167	10	10	9	1	3	3	2	0	2	0	0.27	0.63
263	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(2), ACADM(6), ACADS(5), ACAT1(6), ACAT2(5), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH7A1(2), ALDH9A1(4), AOX1(19), AUH(4), BCAT1(9), BCAT2(6), BCKDHA(7), BCKDHB(3), DBT(3), DLD(7), ECHS1(3), EHHADH(9), HADH(1), HADHA(7), HADHB(5), HIBADH(4), HIBCH(7), HMGCL(3), HMGCS1(4), HMGCS2(8), HSD17B10(4), HSD17B4(10), IVD(4), MCCC1(11), MCCC2(7), MUT(7), OXCT1(10), OXCT2(2), PCCA(10), PCCB(8)	14626083	248	59	245	60	61	108	42	15	20	2	0.27	0.63
264	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(9), CDC25B(3), CDC25C(8), CSK(1), GRB2(3), PRKCA(10), PTPRA(11), SRC(2)	3211443	55	30	52	23	12	18	11	4	10	0	0.27	0.63
265	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	17	AKT1(8), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN1B(5), MAPK1(2), MAPK3(4), NFKB1(12), NFKBIA(3), PAK1(3), RAF1(7), RELA(6)	4670060	63	32	60	19	5	29	15	5	9	0	0.27	0.63
266	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	37	ALK(21), AR(5), ESR2(8), ESRRA(2), HNF4A(15), NPM1(3), NR0B1(8), NR1D1(3), NR1D2(5), NR1H2(4), NR1H3(5), NR1I2(5), NR1I3(7), NR2C2(8), NR2E1(6), NR2F1(5), NR2F2(6), NR3C1(13), NR4A1(4), NR4A2(13), NR5A2(14), PGR(9), PPARA(2), PPARD(6), PPARG(5), RARA(3), RARB(6), RARG(6), ROR1(11), RORA(9), RORC(8), RXRA(1), RXRG(10), THRA(5), THRB(4), VDR(9)	13724575	254	60	244	77	80	108	29	15	20	2	0.27	0.63
267	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(10), AARS2(13), CARS(10), CARS2(1), DARS(4), DARS2(7), EARS2(4), EPRS(11), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(4), HARS2(8), IARS(13), IARS2(21), KARS(7), LARS(23), LARS2(9), MARS(12), MARS2(7), MTFMT(1), NARS(7), NARS2(7), PARS2(4), QARS(6), RARS(11), RARS2(7), SARS(4), SARS2(7), TARS(10), TARS2(10), VARS(8), VARS2(5), WARS(6), WARS2(5), YARS(8), YARS2(3)	19103987	296	71	293	99	82	120	50	12	32	0	0.28	0.63
268	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(7), F13A1(10), F2(9), F2R(8), FGA(30), FGB(6), FGG(12), PLAT(6), PLAU(5), PLG(13), SERPINB2(9), SERPINE1(5)	4749169	120	40	115	23	42	42	21	7	8	0	0.28	0.63
269	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(8), APAF1(19), BAD(2), BAX(4), BCL2L1(3), BID(3), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CYCS(3), EIF2S1(1), PRKCA(10), PTK2(11), PXN(6), STAT1(14), TLN1(28)	7131760	127	43	122	37	35	50	20	7	15	0	0.28	0.63
270	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(6), G6PC2(9), GAA(5), GALE(2), GALK1(3), GALK2(3), GALT(2), GANC(17), GCK(5), GLA(3), GLB1(9), HK1(13), HK2(8), HK3(12), HSD3B7(3), LALBA(1), LCT(30), MGAM(49), PFKM(7), PFKP(11), PGM1(9), PGM3(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), UGP2(8)	12427761	251	61	244	77	75	110	28	17	21	0	0.28	0.63
271	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(7), EIF1(1), EIF2B1(1), EIF2B2(4), EIF2B3(8), EIF2B4(5), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), ELAVL1(6), FLT1(23), FLT4(10), HIF1A(17), KDR(23), NOS3(11), PLCG1(12), PRKCA(10), PTK2(11), PXN(6), SHC1(11), VHL(2)	9724910	186	49	183	53	49	80	20	10	27	0	0.28	0.63
272	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	12	DYRK1B(4), GLI2(11), GLI3(21), GSK3B(11), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), SHH(7), SMO(6), SUFU(7)	4817523	88	34	86	48	26	37	5	3	17	0	0.28	0.63
273	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	19	CHUK(11), FADD(1), IKBKB(15), IL1A(1), IL1R1(5), IRAK1(5), MAP3K14(12), MAP3K7(8), MYD88(1), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TLR4(14), TNF(1), TNFAIP3(2), TNFRSF1A(6), TNFRSF1B(3), TRAF6(4)	7245763	118	41	117	38	24	49	19	8	18	0	0.28	0.64
274	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(11), DNAJC3(8), EIF2S1(1), EIF2S2(5), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6)	3095289	58	27	57	9	9	22	14	4	9	0	0.28	0.64
275	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(18), AMY2A(7), AMY2B(11), ASCC3(25), ATP13A2(6), DDX18(14), DDX19A(1), DDX23(12), DDX4(18), DDX41(2), DDX47(8), DDX50(11), DDX52(7), DDX54(8), DDX55(5), DDX56(6), DHX58(5), ENPP1(11), ENPP3(16), ENTPD7(7), ERCC2(4), ERCC3(11), G6PC(6), G6PC2(9), GAA(5), GANC(17), GBA(4), GBA3(9), GBE1(12), GCK(5), GPI(9), GUSB(5), GYS1(12), GYS2(19), HK1(13), HK2(8), HK3(12), IFIH1(5), LYZL1(2), MGAM(49), NUDT5(1), NUDT8(1), PGM1(9), PGM3(6), PYGB(10), PYGL(9), PYGM(10), RAD54B(14), RAD54L(5), RUVBL2(6), SETX(41), SI(47), SKIV2L2(20), SMARCA2(24), SMARCA5(19), TREH(4), UGDH(3), UGP2(8), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), UXS1(5)	42214570	804	91	776	203	212	294	139	48	104	7	0.28	0.64
276	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(2), ACADL(7), ACADM(6), ACADS(5), ACADSB(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH9A1(4), AOX1(19), BCAT1(9), BCKDHA(7), BCKDHB(3), ECHS1(3), EHHADH(9), HADHA(7), HADHB(5), HIBADH(4), HMGCL(3), IVD(4), MCCC1(11), MCCC2(7), MUT(7), OXCT1(10), PCCA(10), PCCB(8), SDS(3)	12155301	210	55	208	61	52	88	33	16	19	2	0.29	0.64
277	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(4), FUCA1(3), FUCA2(3), GLB1(9), HEXA(3), HEXB(4), LCT(30), MAN2C1(8), MANBA(14), NEU2(5), NEU3(3)	5536196	86	39	85	28	27	30	14	5	10	0	0.29	0.64
278	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	61	AGTR2(8), ATP8A1(14), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), CCKAR(12), CCKBR(7), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CX3CR1(4), CXCR3(5), CXCR4(1), CXCR6(3), EDNRA(6), EDNRB(2), FPR1(4), FSHR(17), GALR1(2), GALR3(3), GALT(2), GHSR(7), GNB2L1(2), GNRHR(4), GPR77(3), GRPR(4), LHCGR(16), MC2R(2), MC3R(8), MC4R(7), MC5R(12), NMBR(4), NPY1R(6), NPY2R(4), NPY5R(10), NTSR1(4), NTSR2(2), OPRD1(2), OPRK1(9), OPRM1(11), OXTR(4), PPYR1(7), SSTR2(3), SSTR3(6), TAC4(1), TACR1(6), TACR2(4), TACR3(9), TRHR(5), TSHR(12)	16498648	351	65	345	131	93	155	49	15	39	0	0.29	0.64
279	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	41	ABCA1(30), ABCA10(27), ABCA12(50), ABCA13(82), ABCA3(19), ABCA4(26), ABCA5(27), ABCA6(24), ABCA8(29), ABCA9(29), ABCB1(28), ABCB10(12), ABCB11(18), ABCB4(29), ABCB5(26), ABCB6(13), ABCB7(16), ABCB8(6), ABCB9(11), ABCC1(23), ABCC10(14), ABCC11(23), ABCC12(24), ABCC2(30), ABCC3(14), ABCC4(12), ABCC5(20), ABCC6(16), ABCC8(19), ABCC9(34), ABCD2(8), ABCD3(9), ABCD4(3), ABCG1(9), ABCG2(8), ABCG4(10), ABCG5(3), ABCG8(9), CFTR(13), TAP1(7), TAP2(2)	38956044	812	99	782	199	212	316	105	49	110	20	0.29	0.64
280	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(5), MMP2(11), MMP9(14), RECK(16), TIMP1(5), TIMP2(3), TIMP3(8), TIMP4(1)	2612748	63	28	61	22	21	27	8	1	6	0	0.29	0.64
281	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(8)	652231	14	12	13	7	5	5	1	0	3	0	0.29	0.64
282	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(6), TAX1BP3(1), UBE2A(4), UBE2B(3), UBE2C(1), UBE2D2(3), UBE2D3(3), UBE2E1(3), UBE2E3(8), UBE2G1(2), UBE2H(3), UBE2J1(5), UBE2L3(4), UBE2L6(1), UBE2M(1), UBE2N(4), UBE3A(13)	3369183	65	31	65	23	12	26	14	1	12	0	0.29	0.64
283	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(17), AKT1(8), ASAH1(9), GNAI1(4), GNB1(3), ITGAV(10), ITGB3(16), MAPK1(2), MAPK3(4), PDGFRA(29), PLCB1(6), PRKCA(10), PTK2(11), SMPD1(12), SMPD2(5), SPHK1(2), SRC(2)	8016538	150	45	144	44	32	65	20	11	20	2	0.30	0.64
284	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GBA3(9), GGT1(10), SHMT1(6), SHMT2(8)	1487297	35	20	32	7	12	11	4	0	6	2	0.30	0.65
285	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	10	ARRB1(7), GNAS(25), GNB1(3), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10)	2929901	66	31	62	20	17	31	5	4	9	0	0.30	0.65
286	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(6), FOSL1(4), FOSL2(7), IFNAR1(9), IFNAR2(8), IFNB1(4), MAPK8(7), NFKB1(12), RELA(6), TNFRSF11A(6), TNFSF11(6), TRAF6(4)	3892354	79	33	75	16	20	28	18	4	9	0	0.31	0.66
287	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(12), ALAS2(11), CPOX(8), FECH(5), HMBS(7), UROD(2), UROS(3)	2723883	51	24	49	9	9	25	6	3	8	0	0.31	0.66
288	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12), MASP1(14), MASP2(6), MBL2(3)	7031380	162	44	155	48	36	75	21	7	19	4	0.31	0.66
289	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(26), POLB(4), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLG(7), POLG2(8), POLH(13), POLI(13), POLK(12), POLL(8), POLQ(23), PRIM1(2), PRIM2(7), REV1(13), REV3L(40), RFC5(7)	14380391	218	62	210	55	60	77	34	10	35	2	0.31	0.66
290	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(4), BTK(11), CALM2(3), CALM3(1), CD79A(1), CD79B(2), ELK1(2), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAPK14(6), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), RAF1(7), SHC1(11), SOS1(21), SYK(6), SYT1(4), VAV1(16)	12090532	199	56	193	63	62	69	29	11	24	4	0.31	0.66
291	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(8), ARSD(9), ARSE(7), CARM1(6), CYP11B1(6), CYP11B2(7), CYP19A1(12), HEMK1(2), HSD11B1(4), HSD17B1(3), HSD17B12(4), HSD17B2(3), HSD17B3(6), HSD17B7(4), HSD17B8(2), HSD3B1(1), HSD3B2(5), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SRD5A1(4), SRD5A2(4), STS(9), SULT1E1(13), SULT2A1(7), SULT2B1(4), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), WBSCR22(9)	16832770	354	61	340	92	96	136	50	23	43	6	0.31	0.66
292	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(10), F2(9), F2R(8), F3(6), F5(46), F7(2), FGA(30), FGB(6), FGG(12), PROC(7), SERPINC1(9), TFPI(11)	5539542	156	41	150	31	53	59	22	10	12	0	0.32	0.67
293	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(10), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD3B1(1), HSD3B2(5)	2460027	35	24	34	16	7	16	5	1	6	0	0.32	0.67
294	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), P4HB(1), SLC23A1(11), SLC23A2(5), SLC2A1(6), SLC2A3(14)	8897731	181	50	173	55	49	73	17	10	24	8	0.32	0.67
295	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(13), ACO2(8), AFMID(6), CS(5), GRHPR(4), HAO1(2), HAO2(7), HYI(2), MDH1(2), MDH2(5), MTHFD1(6), MTHFD1L(12), MTHFD2(3)	4704715	75	36	73	29	27	27	9	5	7	0	0.32	0.67
296	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(8), AKT2(4), AKT3(8), BCL10(2), CARD11(16), CBL(10), CBLB(15), CBLC(5), CD247(5), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD40LG(7), CD8A(3), CD8B(1), CDC42(5), CDK4(4), CHUK(11), CTLA4(2), FOS(6), FYN(7), GRAP2(3), GRB2(3), ICOS(2), IFNG(5), IKBKB(15), IL10(4), IL2(4), IL5(2), ITK(10), JUN(1), LCK(5), LCP2(7), MALT1(4), MAP3K14(12), MAP3K8(12), NCK1(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDK1(7), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKCQ(13), PTPRC(15), RASGRP1(8), RHOA(4), SOS1(21), SOS2(22), TEC(5), TNF(1), VAV1(16), VAV2(5), VAV3(13), ZAP70(10)	32397645	609	87	594	188	163	242	81	32	85	6	0.32	0.67
297	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	11	NDUFA1(1), NDUFA10(8), NDUFA4(2), NDUFA8(6), NDUFB5(2), NDUFB6(1), NDUFS1(13), NDUFS2(5), NDUFV1(4), NDUFV2(3)	2170120	45	23	44	13	12	23	4	3	3	0	0.32	0.67
298	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(29), NRG2(6), NRG3(15), PRKCA(10), PSEN1(4)	3085490	75	28	74	22	15	28	14	9	9	0	0.32	0.67
299	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	10	ADCY1(17), ADRB2(8), GNAS(25), PLCE1(36), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5)	4663846	107	39	102	28	24	47	17	6	13	0	0.32	0.67
300	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(9), BCMO1(4), RDH5(6)	1363973	25	18	25	16	8	9	1	1	6	0	0.33	0.67
301	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(5), GCK(5), GFPT1(11), GNE(8), GNPDA1(3), GNPDA2(5), HEXA(3), HEXB(4), HK1(13), HK2(8), HK3(12), PGM3(6), RENBP(6), UAP1(8)	5825386	103	40	100	37	25	40	17	10	11	0	0.33	0.67
302	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(5), BDH1(6), BDH2(6), HMGCL(3), HMGCS1(4), HMGCS2(8), OXCT1(10), OXCT2(2)	2438278	50	28	49	7	17	22	3	2	4	2	0.33	0.67
303	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(6), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(3), ST6GALNAC4(5), ST8SIA1(4)	1830979	30	21	30	11	13	10	5	0	2	0	0.33	0.68
304	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(1), EPO(2), EPOR(4), GRIN1(5), HIF1A(17), JAK2(21), NFKB1(12), NFKBIA(3), RELA(6), SOD2(3)	4247030	81	30	80	20	15	27	17	5	11	6	0.34	0.68
305	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(8), BAD(2), CHRNB1(3), CHRNG(9), MUSK(16), PTK2(11), PTK2B(16), RAPSN(4), SRC(2), TERT(6), YWHAH(4)	4081164	81	33	78	38	25	35	10	6	5	0	0.34	0.68
306	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(4), ADCY1(17), CAP1(7), CCNB1(8), CDC25C(8), GNAI1(4), GNAS(25), GNB1(3), MAPK1(2), MAPK3(4), PIN1(1), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), RPS6KA1(5), SRC(2)	6402093	111	43	105	27	23	50	13	5	20	0	0.34	0.68
307	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	ATF2(6), CHUK(11), IFNG(5), IKBKB(15), IL2(4), JUN(1), MAP3K5(21), MAP4K5(7), MAPK14(6), MAPK8(7), NFKB1(12), NFKBIA(3), RELA(6), TNFRSF9(3), TRAF2(5)	5854066	112	37	108	34	23	50	16	6	17	0	0.34	0.68
308	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(24), DIAPH1(11), FYN(7), GSN(5), ITGA1(20), ITGB1(12), MAP2K1(2), MAPK1(2), MAPK3(4), MYL2(1), MYLK(17), PFN1(1), PTK2(11), PXN(6), RAF1(7), ROCK1(27), SHC1(11), SRC(2), TLN1(28)	11969837	198	55	193	43	54	81	23	7	29	4	0.34	0.68
309	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	55	AKT1(8), AKT2(4), AKT3(8), BCL10(2), BLNK(4), BTK(11), CARD11(16), CD19(7), CD22(13), CD72(3), CD79A(1), CD79B(2), CHUK(11), FCGR2B(4), FOS(6), GSK3B(11), IKBKB(15), INPP5D(14), JUN(1), LILRB3(2), LYN(7), MALT1(4), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), RAC2(2), RASGRP3(8), SYK(6), VAV1(16), VAV2(5), VAV3(13)	22179917	407	72	399	146	111	166	54	20	54	2	0.34	0.68
310	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12), C8B(4), MASP1(14)	6945340	157	43	149	44	33	73	21	7	19	4	0.34	0.68
311	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(3), CDC25A(9), CDC25B(3), CDC25C(8), CDK7(6), MNAT1(2), SHH(7), XPO1(15)	3028608	61	28	58	13	16	22	11	3	9	0	0.34	0.68
312	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(5), HMGCL(3), OXCT1(10)	1166798	24	18	24	1	6	12	2	0	2	2	0.35	0.68
313	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	62	ADAM10(4), ADAM17(11), ATP6AP1(7), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), CASP3(4), CCL5(4), CDC42(5), CHUK(11), CSK(1), CXCL1(1), EGFR(20), F11R(2), GIT1(9), HBEGF(3), IGSF5(9), IKBKB(15), IL8(3), JAM2(9), JAM3(3), JUN(1), LYN(7), MAP2K4(6), MAP3K14(12), MAPK10(9), MAPK13(2), MAPK14(6), MAPK8(7), MAPK9(7), MET(10), NFKB1(12), NFKB2(10), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(27), PTPN11(8), PTPRZ1(43), RELA(6), SRC(2), TCIRG1(8), TJP1(33)	23503738	462	73	454	151	116	195	63	22	62	4	0.35	0.69
314	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(4), CD3D(3), CD3E(2), CD3G(2), CD4(8), CXCR3(5), IFNG(5), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), JAK2(21), STAT4(9), TYK2(7)	4986735	103	36	100	26	19	44	12	8	14	6	0.36	0.70
315	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), F10(10), F11(10), F12(3), F2(9), F2R(8), F5(46), F8(41), F9(11), FGA(30), FGB(6), FGG(12), KLKB1(13), PROC(7), SERPINC1(9), SERPING1(7)	15568221	366	64	351	82	105	142	48	23	40	8	0.36	0.71
316	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(12), ICAM1(3), ITGAL(13), ITGAM(24), ITGB2(14), SELE(10), SELL(4)	4144977	80	34	78	24	19	33	12	4	10	2	0.36	0.71
317	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(9), CDC25B(3), CDK7(6), CDKN1A(1), CHEK1(4), NEK1(20), WEE1(1)	2580483	44	26	41	12	13	15	5	3	8	0	0.37	0.71
318	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(17), GNAS(25), GNB1(3), PPP2CA(6), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAG2(4), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5)	4833775	102	37	97	27	21	53	8	6	14	0	0.37	0.71
319	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	52	ATP12A(17), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ATP7B(13), COX10(5), COX4I1(2), COX5A(1), COX5B(1), COX6A1(2), COX6B1(4), COX6C(2), COX7A2(2), COX7B(2), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(8), NDUFA4(2), NDUFA8(6), NDUFB5(2), NDUFB6(1), NDUFS1(13), NDUFS2(5), NDUFV1(4), NDUFV2(3), PPA2(5), SDHA(12), SDHB(1), SHMT1(6), UQCRB(3), UQCRC1(6), UQCRH(1)	11571902	217	57	214	64	65	86	28	8	30	0	0.37	0.71
320	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ABP1(12), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), AOX1(19), CARM1(6), DBH(12), DCT(15), DDC(11), ECH1(6), ESCO1(11), ESCO2(6), FAH(7), GOT1(6), GOT2(5), GSTZ1(4), HEMK1(2), HPD(7), LCMT1(4), LCMT2(13), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), NAT6(2), PNMT(3), PNPLA3(6), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SH3GLB1(8), TAT(9), TPO(18), TYR(10), TYRP1(6), WBSCR22(9)	19924235	367	64	357	92	94	149	55	19	46	4	0.37	0.71
321	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(13), ACO2(8), FH(11), IDH1(4), IDH2(7), MDH1(2), MDH2(5), SDHB(1), SUCLA2(5)	3132573	56	30	55	30	18	24	4	5	5	0	0.37	0.71
322	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(5), G6PC(6), GAA(5), GALE(2), GALK1(3), GALK2(3), GALT(2), GANAB(13), GCK(5), GLA(3), GLB1(9), HK1(13), HK2(8), HK3(12), LALBA(1), LCT(30), MGAM(49), PFKM(7), PFKP(11), PGM1(9), PGM3(6)	10815706	206	55	200	71	62	91	23	12	18	0	0.37	0.71
323	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13RA1(14), IL13RA2(3), IL4R(6), JAK2(21), TYK2(7)	2812074	51	26	50	15	9	16	11	4	5	6	0.37	0.71
324	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13RA1(14), IL13RA2(3), IL4R(6), JAK2(21), TYK2(7)	2812074	51	26	50	15	9	16	11	4	5	6	0.37	0.71
325	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(9), ACADS(5), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH5A1(9), ALDH9A1(4), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), HMGCL(3), L2HGDH(3), OXCT1(10), PDHA1(4), PDHA2(10), PDHB(7), SDHB(1), SDS(3)	8755048	159	47	154	44	39	68	22	11	17	2	0.38	0.71
326	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(6), PLCG1(12), PRKCA(10), PTK2B(16)	2362515	44	25	42	24	12	17	6	5	4	0	0.38	0.72
327	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(5), IL8(3), NFKB1(12), NOX1(11), RELA(6), SOD1(2), TNF(1), XDH(10)	3572811	55	28	54	18	16	17	10	3	9	0	0.38	0.72
328	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	JAK2(21), JAK3(9), PIAS1(5), PIAS3(9), PTPRU(20), REG1A(4), SOAT1(10)	3970507	78	32	76	21	18	34	10	3	7	6	0.39	0.72
329	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(13), ACTN2(9), ACTN3(10), BCR(6), CAPN1(4), CAPNS1(3), CAPNS2(6), CRKL(5), CSK(1), FYN(7), GRB2(3), ITGA1(20), ITGB1(12), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(4), MAPK8(7), PPP1R12B(18), PTK2(11), PXN(6), RAF1(7), RAP1A(3), ROCK1(27), SHC1(11), SOS1(21), SRC(2), TLN1(28), VCL(14), ZYX(12)	15465451	279	64	270	75	85	111	28	9	40	6	0.39	0.73
330	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), ZNRD1(1)	8165674	122	43	120	42	34	47	10	11	20	0	0.39	0.74
331	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(5), IL1B(2), MST1(6), MST1R(17), TNF(1)	2108219	31	19	30	13	12	10	1	1	7	0	0.40	0.74
332	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	55	B3GALNT1(5), B3GALT1(10), B3GALT2(8), B3GALT4(6), B3GALT5(6), B3GNT1(7), B3GNT2(4), B3GNT3(2), B3GNT4(5), B3GNT5(6), B4GALNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), B4GALT6(5), FUT1(5), FUT2(3), FUT3(9), FUT6(13), FUT9(12), GBGT1(6), GCNT2(17), PIGA(8), PIGB(10), PIGC(4), PIGF(4), PIGG(12), PIGH(3), PIGK(6), PIGL(1), PIGN(9), PIGO(15), PIGP(2), PIGS(3), PIGT(10), PIGU(3), PIGV(6), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4), ST3GAL5(2), ST3GAL6(8), ST6GALNAC3(10), ST6GALNAC4(5), ST6GALNAC5(5), ST8SIA1(4), ST8SIA5(8), UGCG(5)	15349297	319	63	310	71	88	144	37	18	32	0	0.40	0.74
333	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	22	BMPR1B(6), CCND2(7), CDK4(4), CDKN1B(5), DAZL(5), DMC1(8), EGR1(8), ESR2(8), FSHR(17), GJA4(2), INHA(3), LHCGR(16), MLH1(8), MSH5(15), NCOR1(24), NRIP1(18), PGR(9), PRLR(6), PTGER2(5), SMPD1(12), VDR(9), ZP2(15)	9722759	210	50	202	54	42	98	24	9	35	2	0.40	0.74
334	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	19	IMPA1(4), INPP1(2), INPP4B(17), INPP5A(6), ITPKB(6), OCRL(20), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3CB(19), PIK3CG(25), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCG1(12), PLCG2(27)	13373006	244	57	237	80	65	89	33	14	39	4	0.40	0.74
335	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(7), CHIA(8), CHIT1(5), CMAS(6), CTBS(4), CYB5R1(5), CYB5R3(5), GFPT1(11), GFPT2(12), GNE(8), GNPDA1(3), GNPDA2(5), GNPNAT1(2), HEXA(3), HEXB(4), HK1(13), HK2(8), HK3(12), LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), NAGK(3), NANS(6), NPL(6), PGM3(6), PHPT1(2), RENBP(6), UAP1(8)	9847039	188	50	183	64	45	77	28	13	25	0	0.40	0.74
336	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	121	ALCAM(13), CADM1(5), CADM3(6), CD2(4), CD22(13), CD226(5), CD274(3), CD276(2), CD28(6), CD34(4), CD4(8), CD40(4), CD40LG(7), CD58(1), CD6(8), CD80(7), CD86(6), CD8A(3), CD8B(1), CD99(2), CDH1(15), CDH2(14), CDH3(8), CDH5(9), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CNTN1(17), CNTN2(7), CNTNAP1(13), CNTNAP2(33), CTLA4(2), ESAM(1), F11R(2), GLG1(4), HLA-A(5), HLA-B(3), HLA-DMA(4), HLA-DMB(2), HLA-DOA(3), HLA-DOB(4), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(2), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(3), HLA-G(3), ICAM1(3), ICAM2(5), ICAM3(5), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(12), ITGA8(16), ITGA9(15), ITGAL(13), ITGAM(24), ITGAV(10), ITGB1(12), ITGB2(14), ITGB7(8), ITGB8(5), JAM2(9), JAM3(3), L1CAM(16), MAG(10), MPZ(3), MPZL1(2), NCAM1(13), NEGR1(3), NEO1(16), NLGN1(12), NLGN2(3), NLGN3(21), NRCAM(14), NRXN1(39), NRXN2(22), NRXN3(24), OCLN(5), PTPRC(15), PTPRF(34), PTPRM(19), PVR(2), PVRL1(9), PVRL2(5), PVRL3(9), SDC1(1), SDC2(2), SDC3(2), SDC4(8), SELE(10), SELL(4), SELP(15), SELPLG(11), SIGLEC1(10), SPN(4), VCAM1(9), VCAN(59)	47968973	922	103	897	296	256	381	124	44	106	11	0.41	0.74
337	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(12), ICAM1(3), ITGA4(12), ITGAL(13), ITGB1(12), ITGB2(14), SELE(10), SELL(4)	4673645	80	34	78	26	21	32	11	6	10	0	0.41	0.75
338	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(12), AGT(7), AGTR2(8), EDN1(2), EDNRA(6), EDNRB(2), EGF(24), EGFR(20), FOS(6), JUN(1), MYC(7), NFKB1(12), PLCG1(12), PRKCA(10), RELA(6)	7244568	135	43	130	49	33	55	23	8	16	0	0.41	0.75
339	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK2(21), JAK3(9), MAPK1(2), MAPK3(4), STAT3(12), TYK2(7)	3195669	55	28	54	21	9	24	8	3	5	6	0.41	0.75
340	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(7), B3GNT2(4), B3GNT3(2), B3GNT4(5), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), FUT1(5), FUT2(3), FUT3(9), FUT6(13), FUT9(12), GCNT2(17), ST3GAL6(8), ST8SIA1(4)	4921727	113	35	107	25	27	59	9	6	12	0	0.42	0.75
341	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(3), CDC7(13), CDK2(5), DIAPH2(22), GMNN(3), MCM10(8), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), NACA(20), PCNA(3), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), PRIM1(2), RFC1(15), RFC2(4), RFC3(4), RFC4(4), RFC5(7), RPA1(6), RPA2(2), RPA3(4), RPA4(6), RPS27A(3), UBB(3), UBC(5)	17156137	229	61	222	57	82	90	21	9	27	0	0.42	0.75
342	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(57), MAP2(27), PPP1CA(6), PPP2CA(6), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAR2A(4), PRKAR2B(5), PRKCE(11)	6468057	126	41	121	36	23	46	24	6	24	3	0.42	0.75
343	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(19), ARHGAP5(24), ARHGDIB(2), CASP1(7), CASP10(10), CASP3(4), CASP9(3), CYCS(3), GZMB(2), JUN(1), PRF1(8)	4148801	83	31	80	18	22	27	12	4	16	2	0.43	0.77
344	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	65	CALM2(3), CALM3(1), CALML6(4), CDIPT(1), CDS1(3), CDS2(2), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), IMPA1(4), IMPA2(6), INPP1(2), INPP4B(17), INPP5A(6), INPP5B(8), INPP5D(14), ITGB1BP3(1), ITPK1(2), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), OCRL(20), PI4KA(18), PI4KB(12), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3C3(11), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PRKCA(10), PRKCG(10), PTPMT1(1), SYNJ1(27), SYNJ2(13)	39076500	731	92	715	243	204	281	112	37	89	8	0.43	0.77
345	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(7), FUT1(5), FUT2(3), FUT9(12), GCNT2(17), ST8SIA1(4)	2126144	48	25	45	10	12	24	5	3	4	0	0.43	0.77
346	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(6), SNCA(2), SNCAIP(12), UBE2E2(3), UBE2F(1), UBE2G1(2), UBE2L3(4), UBE2L6(1)	2165818	40	24	40	13	13	17	4	4	2	0	0.44	0.78
347	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(7), PLCD1(5), PRKCA(10), TGM2(9)	1769078	31	22	31	20	10	11	5	3	2	0	0.44	0.78
348	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(13), CTH(5), MUT(7)	1579551	34	21	33	7	8	16	4	1	5	0	0.44	0.78
349	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	18	CCNA1(4), CCNB1(8), CCND2(7), CCND3(5), CCNH(3), CDC25A(9), CDK2(5), CDK4(4), CDK6(3), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), RBL1(17)	4385889	84	33	80	17	16	36	12	6	14	0	0.44	0.78
350	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(5), ABAT(9), ACADS(5), ACAT1(6), ACAT2(5), ACSM1(12), AKR1B10(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH5A1(9), ALDH7A1(2), ALDH9A1(4), BDH1(6), BDH2(6), DDHD1(14), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADH(1), HADHA(7), HMGCL(3), HMGCS1(4), HMGCS2(8), HSD17B10(4), HSD17B4(10), HSD3B7(3), ILVBL(7), L2HGDH(3), OXCT1(10), OXCT2(2), PDHA1(4), PDHA2(10), PDHB(7), PLA1A(5), PPME1(1), PRDX6(2), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	13856981	253	56	244	64	65	113	33	15	23	4	0.45	0.78
351	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(19), BID(3), BIRC2(13), BIRC3(3), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CFLAR(7), CHUK(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), GAS2(7), LMNA(8), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), SPTAN1(29), TNFRSF10A(3), TNFRSF10B(5), TNFRSF25(1), TNFSF10(1), TNFSF12(4), TRAF2(5)	10869242	193	51	190	52	50	76	24	10	33	0	0.45	0.78
352	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(3), BHMT(2), CBS(13), CTH(5), DNMT1(15), DNMT3A(13), DNMT3B(15), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), MTAP(4), MTFMT(1), MTR(13), SRM(1), TAT(9)	6919050	131	42	121	53	32	62	17	3	17	0	0.45	0.78
353	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(4), ABP1(12), ACAT1(6), ACAT2(5), ACMSD(8), AFMID(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AOC2(6), AOC3(14), AOX1(19), ASMT(3), CARM1(6), CAT(5), CYP1A1(9), CYP1A2(6), CYP1B1(3), DDC(11), ECHS1(3), EHHADH(9), GCDH(5), HAAO(4), HADH(1), HADHA(7), HEMK1(2), HSD17B10(4), HSD17B4(10), INMT(4), KMO(11), KYNU(5), LCMT1(4), LCMT2(13), LNX1(9), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), NFX1(14), OGDH(11), OGDHL(18), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), TDO2(3), TPH1(14), TPH2(9), WARS(6), WARS2(5), WBSCR22(9)	20922060	398	70	387	99	95	166	60	25	43	9	0.45	0.79
354	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), FDXR(6), SHMT1(6)	5242465	94	36	94	30	22	41	12	3	16	0	0.46	0.80
355	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(7), ADSS(8), DHFR(3), HPRT1(2), IMPDH1(5), MTHFD2(3), POLB(4), POLD1(15), POLG(7), PRPS2(10), RRM1(4), SRM(1)	4120599	69	33	68	22	16	31	11	5	6	0	0.47	0.81
356	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(6), ALDOB(9), ALDOC(4), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GAPDHS(10), GCK(5), GOT1(6), GOT2(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHAL6B(2), LDHB(2), LDHC(3), MDH1(2), MDH2(5), PC(8), PCK1(15), PDHA1(4), PDHA2(10), PDHB(7), PDHX(8), PFKM(7), PFKP(11), PGAM1(2), PGAM2(2), PGK1(6), PGK2(5), PKLR(10), PKM2(5), TNFAIP1(3), TPI1(1)	13872277	244	57	239	81	69	102	30	16	25	2	0.47	0.81
357	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	4956143	88	35	88	30	22	38	10	3	15	0	0.48	0.81
358	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	4956143	88	35	88	30	22	38	10	3	15	0	0.48	0.81
359	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	4956143	88	35	88	30	22	38	10	3	15	0	0.48	0.81
360	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(7), CR1(28), FCGR2B(4), HLA-DRB1(1), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15)	4526899	85	33	83	34	24	37	11	4	7	2	0.48	0.81
361	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL15(1), IL16(17), IL18(1), IL1A(1), IL2(4), IL5(2), IL6(2), IL8(3), LTA(3), TNF(1)	3594321	58	28	56	22	16	25	7	2	8	0	0.48	0.81
362	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(10), B3GALT2(8), B3GALT5(6), B3GNT5(6), FUT1(5), FUT2(3), FUT3(9), ST3GAL3(6), ST3GAL4(4)	2575225	57	26	54	16	12	28	7	3	7	0	0.48	0.81
363	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(2), CBS(13), CTH(5), DNMT1(15), DNMT3A(13), DNMT3B(15), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), MTR(13)	5873186	113	38	104	44	26	55	14	2	16	0	0.48	0.82
364	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	11	CHUK(11), DUSP1(2), IKBKAP(14), IKBKB(15), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), TNFAIP3(2), TRAF3(6), TRAF6(4)	5344518	87	34	86	24	14	39	14	6	14	0	0.48	0.82
365	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(5), ASL(4), CPS1(24), GLS(10), GLUD1(4), GOT1(6)	2621352	53	24	51	13	12	20	7	2	8	4	0.49	0.82
366	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(6), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), HGSNAT(9), HPSE(4), HPSE2(5), HYAL1(4), HYAL2(1), IDS(6), LCT(30), NAGLU(3), SPAM1(12)	6792858	103	41	101	51	28	45	12	8	10	0	0.49	0.82
367	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(4), MAX(8), MYC(7), SP1(6), SP3(12), WT1(3)	2119691	40	23	38	10	7	20	7	1	3	2	0.49	0.82
368	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AICDA(3), CAD(38), CANT1(5), CDA(1), CTPS(10), CTPS2(10), DCK(4), DCTD(5), DHODH(3), DPYD(16), DPYS(3), DUT(1), ENTPD1(6), ENTPD3(8), ENTPD4(4), ENTPD5(2), ENTPD6(15), ITPA(1), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT2(3), PNPT1(9), POLA1(26), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), PRIM1(2), PRIM2(7), RFC5(7), RRM1(4), RRM2(5), RRM2B(5), TK1(2), TK2(7), TXNRD1(10), TXNRD2(4), TYMS(1), UCK1(5), UCK2(6), UMPS(7), UPB1(9), UPP1(4), UPP2(7), UPRT(6), ZNRD1(1)	27818405	472	81	461	144	110	192	71	32	65	2	0.49	0.82
369	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(3), RAB27A(3), RAB3A(5), RAB4A(5), RAB5A(2), RAB6A(2), RAB9A(7)	1537248	32	18	28	8	9	14	3	0	6	0	0.49	0.82
370	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(24), EGFR(20), MAP2K1(2), MAPK14(6), NCOR2(24), RARA(3), RXRA(1), THRA(5), THRB(4)	4308931	89	33	87	33	23	36	14	6	10	0	0.50	0.82
371	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(9), ACACA(27), ACACB(31), ACADM(6), ACAT1(6), ACAT2(5), ACSS1(4), ACSS2(11), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH7A1(2), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), HIBCH(7), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), MLYCD(5), MUT(7), PCCA(10), PCCB(8), SUCLA2(5), SUCLG1(1)	13481512	210	53	204	53	58	82	31	13	22	4	0.50	0.82
372	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), DAG1(7), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), NFAT5(13), PDE6A(13), PDE6B(6), PDE6C(14), PDE6D(1), SLC6A13(10), TF(15)	12139049	202	51	199	68	60	85	23	6	26	2	0.50	0.83
373	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(9), IFNB1(4), PTPRU(20), REG1A(4), STAT1(14), STAT2(12), TYK2(7)	3473387	70	32	68	21	17	33	11	3	6	0	0.50	0.83
374	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(6), CD3D(3), CD3E(2), CD3G(2), CD80(7), CD86(6), CTLA4(2), GRB2(3), HLA-DRB1(1), ICOS(2), IL2(4), ITK(10), LCK(5), PTPN11(8)	3205468	61	27	61	13	12	31	9	2	7	0	0.50	0.83
375	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), HSD3B7(3), PON1(12), PON2(8), PON3(1), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	3072823	67	30	65	17	21	25	11	3	7	0	0.50	0.83
376	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(3), CD3E(2), CD3G(2)	407734	7	6	7	1	0	4	1	0	2	0	0.51	0.83
377	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(13), CTH(5), GGT1(10), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), PAPSS1(6), PAPSS2(6), SCLY(4), SEPHS1(13)	4130398	94	33	88	29	31	39	14	2	8	0	0.51	0.83
378	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(5), FUT2(3), FUT3(9), FUT6(13), ST3GAL3(6)	1534380	36	20	36	14	4	26	4	1	1	0	0.51	0.83
379	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), GOT1(6), GOT2(5), GPT2(7), MDH1(2), MDH2(5), ME1(10), ME3(7), PGK1(6), PGK2(5), PKLR(10), PKM2(5), RPE(3), RPIA(7), TKT(7), TKTL1(10), TKTL2(12), TPI1(1)	6529241	131	41	128	43	35	57	14	7	16	2	0.51	0.83
380	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(12), ICAM1(3), ITGA4(12), ITGAL(13), ITGAM(24), ITGB1(12), ITGB2(14), SELE(10), SELL(4), SELP(15)	6087091	119	40	114	29	30	50	14	6	17	2	0.52	0.84
381	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(5), ATIC(9), ATP6V0C(2), DHFR(3), GART(8), MTHFD1(6), MTHFD1L(12), MTHFD2(3), MTHFR(7), MTR(13), SHMT1(6), SHMT2(8), TYMS(1)	6300757	92	37	88	32	23	42	9	3	13	2	0.52	0.84
382	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(7), IDI1(4), SQLE(6)	1130709	20	14	20	6	5	5	5	3	2	0	0.52	0.84
383	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	10	ADCY1(17), ADRB2(8), CFTR(13), GNAS(25), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), SLC9A3R1(3)	4062044	87	33	82	22	20	40	9	5	13	0	0.52	0.84
384	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(4), AASS(6), ACAT1(6), ACAT2(5), AKR1B10(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), BBOX1(4), DLST(10), DOT1L(8), ECHS1(3), EHHADH(9), EHMT2(6), GCDH(5), HADH(1), HADHA(7), HSD17B10(4), HSD17B4(10), HSD3B7(3), NSD1(36), OGDH(11), OGDHL(18), PIPOX(6), PLOD1(4), PLOD2(16), PLOD3(11), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SETD1A(12), SETD7(6), SETDB1(19), SHMT1(6), SHMT2(8), SPCS1(1), SPCS3(3), SUV39H1(10), SUV39H2(6), TMLHE(5)	19491406	319	68	305	82	78	134	49	19	35	4	0.52	0.84
385	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(6), ARSD(9), ARSE(7), ASAH1(9), GAL3ST1(13), GALC(7), GBA(4), GLA(3), GLB1(9), LCT(30), NEU2(5), NEU3(3), PPAP2A(4), PPAP2B(3), SMPD1(12), SMPD2(5), SPTLC1(6), SPTLC2(6), UGCG(5)	7860710	146	43	145	44	43	68	12	9	14	0	0.52	0.84
386	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(3), CD3E(2), CD3G(2), CD4(8), FYN(7), HLA-DRB1(1), LCK(5), PTPRC(15), ZAP70(10)	3184675	53	27	53	15	11	25	5	2	10	0	0.53	0.84
387	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(9), F2R(8), GNAI1(4), GNB1(3), ITGA1(20), ITGB1(12), MAP2K1(2), MAPK1(2), MAPK3(4), PLA2G4A(11), PLCB1(6), PRKCA(10), PTGS1(8), PTK2(11), RAF1(7), SRC(2), SYK(6), TBXAS1(6)	8327716	131	44	129	43	34	51	20	7	19	0	0.53	0.84
388	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(27), CPT1A(10), LEP(2), LEPR(15), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKAG1(2), PRKAG2(4)	5100499	84	34	82	25	22	33	9	5	15	0	0.53	0.84
389	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	GATA3(4), IL5(2), MAF(2), MAP2K3(8), MAPK14(6), NFATC2(15), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5)	3405750	58	29	56	22	10	28	4	6	10	0	0.53	0.85
390	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	ACTR2(7), ACTR3(3), AKT1(8), ANGPTL2(9), DAG1(7), DGKA(15), ETFA(4), GCA(3), ITGA9(15), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), MAP2K1(2), MAPK1(2), MAPK3(4), NR1I3(7), PAK1(3), PDE3A(17), PDE3B(15), PI3(3), PIK3C2G(22), PIK3CD(10), PLDN(4), PSME1(2), RIPK3(2), RPS4X(4), SGCB(4), VASP(2)	15830165	272	61	266	89	72	111	40	8	35	6	0.54	0.85
391	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(4), ABP1(12), ACAT1(6), ACAT2(5), ACMSD(8), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), AOC2(6), AOC3(14), AOX1(19), ASMT(3), CAT(5), CYP19A1(12), CYP1A1(9), CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2D6(2), CYP2E1(5), CYP2F1(5), CYP2J2(5), CYP3A4(14), CYP3A5(7), CYP3A7(9), CYP4B1(4), CYP4F8(9), CYP51A1(4), DDC(11), ECHS1(3), EHHADH(9), GCDH(5), HAAO(4), HADHA(7), KMO(11), KYNU(5), MAOA(14), MAOB(7), SDS(3), TDO2(3), TPH1(14), WARS(6), WARS2(5)	19356132	371	67	364	108	101	139	59	22	43	7	0.54	0.85
392	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(12), ACADM(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AOC2(6), AOC3(14), CNDP1(6), DPYD(16), DPYS(3), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), HIBCH(7), MLYCD(5), SMS(8), SRM(1), UPB1(9)	9239023	164	47	159	46	48	58	26	12	20	0	0.54	0.85
393	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(4), GPLD1(10), PGAP1(11), PIGA(8), PIGB(10), PIGC(4), PIGF(4), PIGG(12), PIGH(3), PIGK(6), PIGL(1), PIGN(9), PIGO(15), PIGP(2), PIGS(3), PIGT(10), PIGU(3), PIGV(6), PIGW(8), PIGX(2), PIGZ(6)	8032790	137	45	135	24	37	56	20	8	16	0	0.54	0.85
394	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(19), AGT(7), AGTR2(8), CMA1(1), COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), REN(3)	9026552	182	47	174	50	47	78	16	10	23	8	0.54	0.85
395	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(13), ACO2(8), CS(5), DLD(7), DLST(10), FH(11), IDH1(4), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), PC(8), PCK1(15), SDHA(12), SDHB(1), SUCLA2(5), SUCLG1(1)	6893238	133	42	129	56	40	58	17	7	11	0	0.55	0.85
396	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	AANAT(4), ACHE(4), CHAT(1), DBH(12), DDC(11), GAD1(8), GAD2(12), HDC(10), MAOA(14), PAH(1), PNMT(3), TPH1(14)	4650223	94	34	93	17	20	32	21	1	18	2	0.55	0.85
397	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(2), HLA-A(5), IL18(1), ITGB1(12), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(3), KLRD1(2), MAP2K1(2), MAPK3(4), PAK1(3), PTK2B(16), SYK(6), VAV1(16)	5202552	78	34	75	24	20	29	10	5	12	2	0.55	0.86
398	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	25	CALM2(3), CALM3(1), CHUK(11), EGR2(8), EGR3(9), MYC(7), NFATC2(15), NFKB1(12), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), RELA(6), SYT1(4), VIP(2)	8183838	131	43	127	47	28	53	20	9	21	0	0.55	0.86
399	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	46	ACAA1(5), ACAA2(2), ACADL(7), ACADM(6), ACADS(5), ACADSB(4), ACADVL(6), ACAT1(6), ACAT2(5), ACOX1(4), ACOX3(8), ACSL1(13), ACSL3(10), ACSL5(18), ACSL6(13), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CPT1A(10), CPT1C(15), CPT2(7), CYP4A11(5), CYP4A22(8), ECHS1(3), EHHADH(9), GCDH(5), HADH(1), HADHA(7), HADHB(5), HSD17B10(4), HSD17B4(10)	16278768	269	55	263	72	65	122	39	13	28	2	0.56	0.87
400	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(6), ERCC3(11), GTF2B(5), GTF2E1(4), GTF2E2(5), GTF2F2(1), GTF2H1(8), GTF2H2(3), GTF2H4(2), ILK(8), MNAT1(2), POLR1A(15), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3B(7), POLR3D(3), POLR3E(5), POLR3H(3), TAF12(1), TAF5(6), TAF6(8), TAF7(3), TAF9(2), TBP(5)	12365860	190	52	183	68	41	81	21	15	32	0	0.56	0.87
401	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(38), BRCA1(19), BRCA2(51), CHEK1(4), CHEK2(14), FANCC(8), FANCD2(17), FANCE(10), FANCF(4), FANCG(8), HUS1(5), MRE11A(12), RAD1(3), RAD17(9), RAD50(19), RAD51(4), RAD9A(2), TREX1(1)	13161969	228	57	222	33	47	88	38	13	36	6	0.57	0.87
402	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	88	ANK2(42), B3GALT4(6), CDR1(2), DGKI(21), FAU(1), IL6ST(10), MRPL19(6), PIGK(6), RPL10(5), RPL11(4), RPL12(1), RPL14(2), RPL15(1), RPL17(5), RPL18(4), RPL18A(4), RPL19(4), RPL21(2), RPL23(1), RPL24(3), RPL27(1), RPL27A(1), RPL28(2), RPL29(3), RPL3(5), RPL30(2), RPL31(1), RPL35(1), RPL35A(2), RPL37(3), RPL38(1), RPL3L(3), RPL4(4), RPL5(6), RPL6(2), RPL7(2), RPL8(1), RPL9(1), RPLP0(6), RPS10(2), RPS12(3), RPS13(1), RPS14(1), RPS18(4), RPS20(3), RPS21(2), RPS24(4), RPS25(1), RPS27(2), RPS27A(3), RPS29(2), RPS3(2), RPS3A(2), RPS4X(4), RPS5(1), RPS6(6), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15), RPS6KB1(3), RPS6KB2(6), RPS7(3), RPS8(5), RPS9(1), RPSA(1), SLC36A2(5), TBC1D10C(2), TSPAN9(4), UBB(3), UBC(5)	17766543	311	62	302	106	89	115	45	12	50	0	0.57	0.87
403	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	44	APAF1(19), BAD(2), BAX(4), BCL2A1(2), BCL2L1(3), BCL2L2(2), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP9(3), CD40(4), CD40LG(7), CRADD(3), CYCS(3), DAXX(11), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), IKBKE(3), LTA(3), MCL1(1), NFKB1(12), NFKBIA(3), NGFR(4), NR3C1(13), NTRK1(11), PTPN13(27), RIPK1(8), TFG(5), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF1(5), TRAF2(5), TRAF3(6), TRAF6(4)	14669581	247	57	243	70	67	93	38	13	34	2	0.57	0.87
404	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), NCK1(4), NCKAP1(10), NTRK1(11), PIR(4), WASF1(3), WASF2(5), WASF3(9), WASL(8)	5403073	82	35	82	32	27	34	6	3	12	0	0.57	0.87
405	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(13), CKM(3), EIF4E(4), FBL(4), LDHA(6), LDHB(2), LDHC(3), MAPK14(6), NCL(2)	2977223	43	27	43	21	11	15	7	5	3	2	0.58	0.88
406	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(19), BIRC2(13), BIRC3(3), CASP10(10), CASP3(4), CASP7(4), CASP9(3), DFFA(1), DFFB(3), GZMB(2), PRF1(8), SCAP(16), SREBF1(6), SREBF2(10)	5433665	102	36	98	30	31	36	12	7	16	0	0.58	0.88
407	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(5), GLS(10), GLUD1(4), OAT(7)	1641930	28	19	26	10	5	13	5	1	4	0	0.58	0.88
408	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(11), DLG4(13), EPHB2(10), F2(9), F2RL1(3), F2RL2(3), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(17), MAPK8(7), MYEF2(6), PLD1(16), PLD2(7), PLD3(3), PTK2(11), RAF1(7), RASAL1(14), SRC(2), TEC(5), VAV1(16)	9304748	165	48	160	58	43	69	26	5	20	2	0.58	0.88
409	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM2(3), CALM3(1), CCL4(1), CXCL12(3), CXCR4(1), FOS(6), JUN(1), MAPK14(6), MAPK8(7), PLCG1(12), PRKCA(10), PTK2B(16), SYT1(4)	4564422	71	33	69	32	20	24	9	8	10	0	0.59	0.88
410	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(3), ALDH18A1(13), ARG1(5), ARG2(6), ASL(4), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), GATM(8), GLUD1(4), OAT(7), ODC1(3), OTC(8), SMS(8)	5381563	108	36	104	35	27	46	16	5	10	4	0.59	0.89
411	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	8	CREB1(5), FOS(6), JUN(1), KEAP1(8), MAPK1(2), MAPK14(6), MAPK8(7), PRKCA(10)	2467436	45	24	45	9	9	18	5	5	8	0	0.59	0.89
412	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(10), F11(10), F12(3), F13B(13), F2(9), F5(46), F7(2), F8(41), F9(11), FGA(30), FGB(6), FGG(12), LPA(14), PLAT(6), PLAU(5), PLG(13), SERPINB2(9), SERPINE1(5), SERPINF2(5), VWF(31)	12089576	281	53	269	73	83	112	44	13	25	4	0.60	0.89
413	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(7), ACTR3(3), ARHGAP1(2), ARHGAP4(15), ARHGAP5(24), ARHGAP6(13), ARHGEF1(11), ARHGEF11(22), ARHGEF5(11), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), BAIAP2(1), CFL1(1), DIAPH1(11), GSN(5), LIMK1(7), MYL2(1), MYLK(17), OPHN1(13), PFN1(1), PIP5K1A(7), PIP5K1B(6), PPP1R12B(18), ROCK1(27), SRC(2), TLN1(28), VCL(14)	16054825	281	63	274	79	89	106	29	18	31	8	0.60	0.89
414	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(23), ABCC2(30), ABCG2(8), CES1(12), CES2(3), CYP3A4(14), CYP3A5(7), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4)	7739298	148	41	142	40	35	64	22	11	14	2	0.60	0.89
415	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(12), NFKBIA(3), PLCB1(6), PRKCA(10), RELA(6)	2891900	37	23	37	16	4	13	10	4	6	0	0.60	0.89
416	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	10	CAPN1(4), CAPNS1(3), CAPNS2(6), CDK5(1), CDK5R1(5), CSNK1A1(5), GSK3B(11), MAPT(11), PPP2CA(6)	2556344	52	24	51	18	10	24	4	3	11	0	0.61	0.89
417	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(4), CANX(8), CD4(8), CD74(1), CD8A(3), CD8B(1), CIITA(21), CREB1(5), CTSB(1), CTSL1(7), CTSS(6), HLA-A(5), HLA-B(3), HLA-DMA(4), HLA-DMB(2), HLA-DOA(3), HLA-DOB(4), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(2), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(3), HLA-G(3), HSP90AA1(7), HSP90AB1(20), HSPA5(8), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), KIR2DL1(6), KIR2DL3(2), KIR2DL4(3), KIR2DS4(6), KIR3DL1(7), KIR3DL2(7), KIR3DL3(3), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(3), KLRD1(2), LGMN(8), LTA(3), NFYA(7), NFYB(2), NFYC(1), PDIA3(6), PSME1(2), PSME2(2), RFX5(13), RFXANK(4), RFXAP(1), TAP1(7), TAP2(2), TAPBP(5)	16547882	278	58	272	69	80	119	31	10	36	2	0.61	0.89
418	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(8), CS(5), FH(11), IDH2(7), MDH1(2), OGDH(11), SDHA(12), SUCLA2(5)	3326163	61	28	60	26	17	30	6	4	4	0	0.61	0.89
419	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(9), ACTB(5), ARHGEF2(10), ARPC5(1), CD14(2), CDC42(5), CDH1(15), CLDN1(2), CTTN(8), EZR(6), FYN(7), HCLS1(8), ITGB1(12), LY96(4), NCK1(4), NCK2(8), NCL(2), OCLN(5), PRKCA(10), RHOA(4), ROCK1(27), ROCK2(15), TLR4(14), TLR5(8), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3), WASL(8), YWHAQ(3), YWHAZ(1)	17742404	306	65	302	92	80	133	27	11	53	2	0.61	0.89
420	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(9), ACTB(5), ARHGEF2(10), ARPC5(1), CD14(2), CDC42(5), CDH1(15), CLDN1(2), CTTN(8), EZR(6), FYN(7), HCLS1(8), ITGB1(12), LY96(4), NCK1(4), NCK2(8), NCL(2), OCLN(5), PRKCA(10), RHOA(4), ROCK1(27), ROCK2(15), TLR4(14), TLR5(8), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3), WASL(8), YWHAQ(3), YWHAZ(1)	17742404	306	65	302	92	80	133	27	11	53	2	0.61	0.89
421	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(6), GPR161(3), GPR171(6), GPR18(2), GPR34(6), GPR39(10), GPR45(7), GPR65(10), GPR68(4), GPR75(10)	3491073	69	28	65	31	16	28	18	3	4	0	0.61	0.89
422	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(12), AOC2(6), AOC3(14), CES1(12), ESD(2)	2205970	46	23	43	15	13	16	10	3	4	0	0.61	0.89
423	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(5), ATIC(9), DHFR(3), GART(8), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(3), MTHFR(7), MTR(13), SHMT1(6), SHMT2(8), TYMS(1)	6443201	91	36	87	32	22	42	9	3	13	2	0.62	0.89
424	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGK1(6), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	16614324	284	61	278	94	83	116	34	16	33	2	0.62	0.89
425	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGK1(6), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	16614324	284	61	278	94	83	116	34	16	33	2	0.62	0.89
426	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	23	ARHGDIB(2), BAG4(4), CASP2(9), CASP3(4), CRADD(3), DFFA(1), DFFB(3), FADD(1), JUN(1), LMNA(8), LMNB1(5), MADD(21), MAP2K4(6), MAP3K7(8), MAPK8(7), PAK1(3), PAK2(6), PRKDC(70), RIPK1(8), SPTAN1(29), TNF(1), TNFRSF1A(6), TRAF2(5)	11491837	211	52	208	50	50	82	30	15	31	3	0.62	0.89
427	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), GOT1(6), GOT2(5), GPT2(7), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PGK1(6), PKLR(10), PKM2(5), RPE(3), RPIA(7), TKT(7), TPI1(1)	5828254	111	37	109	37	31	47	13	6	12	2	0.62	0.89
428	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), NFS1(8), PHPT1(2), THTPA(1), TPK1(2)	2210750	43	22	41	18	7	17	8	1	10	0	0.62	0.89
429	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(12), CLOCK(11), CRY1(6), CRY2(4), CSNK1E(10), PER1(15)	2749217	58	24	57	17	16	20	10	2	8	2	0.62	0.89
430	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23)	5901627	64	36	63	15	15	29	9	4	7	0	0.62	0.89
431	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(13), G6PD(3), GCLC(8), GCLM(3), GGT1(10), GPX3(4), GPX5(7), GPX6(6), GPX7(1), GSR(5), GSS(5), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTA5(2), GSTK1(5), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), IDH1(4), IDH2(7), MGST1(3), MGST3(1), TXNDC12(5)	7001266	129	43	122	48	49	41	18	11	8	2	0.62	0.89
432	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ALDH4A1(2), ARG1(5), ARG2(6), ASL(4), ASS1(3), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), DAO(5), EPRS(11), GATM(8), GLUD1(4), GLUD2(9), GOT1(6), GOT2(5), LAP3(7), NOS1(21), NOS3(11), OAT(7), OTC(8), P4HA1(8), P4HA2(10), P4HA3(5), PARS2(4), PYCR2(3), PYCRL(1), RARS(11), RARS2(7)	11471044	210	52	204	79	48	98	32	10	18	4	0.62	0.89
433	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(14), EIF2AK4(12), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF5(3), GSK3B(11), PPP1CA(6)	4058459	64	32	63	16	16	27	5	5	11	0	0.63	0.89
434	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(4), ATF3(4), CYR61(3), DUSP14(3), EIF4E(4), HBEGF(3), IFNG(5), IFRD1(10), IL18(1), IL1A(1), IL1R1(5), MYOG(1), NR4A3(10), WDR1(10)	3627542	68	29	67	20	23	24	13	2	6	0	0.63	0.89
435	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(6), FARSB(7), GOT1(6), GOT2(5), PAH(1), TAT(9), YARS(8), YARS2(3)	3071867	47	25	46	14	14	17	9	4	3	0	0.63	0.89
436	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(4), LDLR(12), MBTPS1(13), MBTPS2(15), SCAP(16), SREBF1(6), SREBF2(10)	3548194	76	30	75	20	21	34	7	4	10	0	0.63	0.89
437	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ACCN1(4), ADCY4(8), ADCY6(16), ADCY8(16), CACNA1A(19), CACNA1B(1), GNAS(25), GNAT3(7), GNB1(3), GNB3(4), GNG13(2), GNG3(3), GRM4(16), ITPR3(23), KCNB1(17), PDE1A(12), PLCB2(9), PRKACA(4), PRKACB(2), PRKACG(6), PRKX(4), SCNN1A(5), SCNN1B(6), SCNN1G(13), TAS1R1(11), TAS1R2(12), TAS2R1(4), TAS2R10(6), TAS2R13(4), TAS2R14(6), TAS2R16(3), TAS2R3(2), TAS2R38(4), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(2), TAS2R42(5), TAS2R46(1), TAS2R5(5), TAS2R50(4), TAS2R60(7), TAS2R7(4), TAS2R8(6), TAS2R9(1)	18971820	329	60	322	123	91	141	42	17	38	0	0.64	0.90
438	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	104	ATP12A(17), ATP4A(13), ATP4B(2), ATP5A1(11), ATP5B(4), ATP5C1(1), ATP5E(1), ATP5F1(5), ATP5G1(4), ATP5G2(1), ATP5I(1), ATP5J(4), ATP5L(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), COX10(5), COX15(4), COX4I1(2), COX4I2(2), COX5A(1), COX5B(1), COX6A1(2), COX6B1(4), COX6C(2), COX7A2(2), COX7B(2), COX7B2(2), COX7C(2), COX8A(1), COX8C(2), CYC1(2), LHPP(2), NDUFA1(1), NDUFA10(8), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(2), NDUFA4L2(1), NDUFA6(3), NDUFA8(6), NDUFA9(4), NDUFAB1(2), NDUFB1(1), NDUFB5(2), NDUFB6(1), NDUFB8(1), NDUFC1(1), NDUFC2(2), NDUFS1(13), NDUFS2(5), NDUFS4(2), NDUFS5(1), NDUFS8(3), NDUFV1(4), NDUFV2(3), NDUFV3(2), PPA1(5), PPA2(5), SDHA(12), SDHB(1), SDHC(6), SDHD(1), TCIRG1(8), UQCRB(3), UQCRC1(6), UQCRC2(4), UQCRH(1), UQCRQ(2)	18348030	339	67	336	93	94	141	39	18	47	0	0.64	0.90
439	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(4), APAF1(19), CASP3(4), CASP9(3), CYCS(3), DAXX(11), FAS(7), FASLG(6), HSPB2(1), IL1A(1), MAPKAPK2(6), MAPKAPK3(4), TNF(1)	3808943	70	30	69	20	19	25	11	5	10	0	0.64	0.90
440	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	11	APAF1(19), BAX(4), CDK2(5), CDK4(4), CDKN1A(1), MDM2(6), PCNA(3), TIMP3(8)	2732487	50	24	49	15	12	20	7	3	8	0	0.65	0.90
441	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	30	ABAT(9), ACACA(27), ACADL(7), ACADM(6), ACADSB(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), LDHA(6), LDHB(2), LDHC(3), MLYCD(5), MUT(7), PCCA(10), PCCB(8), SDS(3), SUCLA2(5), SUCLG1(1)	11163212	174	48	171	52	45	63	30	13	23	0	0.65	0.91
442	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(5), ENO2(3), ENO3(4), FARS2(2), GOT1(6), GOT2(5), PAH(1), TAT(9), YARS(8)	2926077	43	23	42	14	9	19	6	4	5	0	0.66	0.91
443	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(7), LIPT1(5)	529863	12	9	12	3	2	7	2	0	1	0	0.66	0.91
444	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(8), ADRBK2(10), ARRB2(3), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CLCA1(20), CLCA2(13), CLCA4(16), CNGA3(13), CNGA4(11), CNGB1(14), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(3), PDE1C(14), PRKACA(4), PRKACB(2), PRKACG(6), PRKG1(9), PRKG2(10), PRKX(4)	10456011	207	51	204	85	54	85	31	7	28	2	0.66	0.91
445	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(6), B4GALNT1(5), GLB1(9), HEXA(3), HEXB(4), LCT(30), SLC33A1(8), ST3GAL1(2), ST3GAL2(4), ST3GAL5(2), ST6GALNAC3(10), ST6GALNAC4(5), ST6GALNAC5(5), ST8SIA1(4), ST8SIA5(8)	5487440	105	36	104	34	34	41	12	7	11	0	0.66	0.91
446	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(5), ASNS(9), ASRGL1(2), CA1(4), CA12(3), CA13(2), CA14(4), CA2(5), CA3(4), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(5), CA8(5), CA9(8), CPS1(24), CTH(5), GLS(10), GLS2(9), GLUD1(4), GLUD2(9), GLUL(6), HAL(6)	7353074	142	41	136	47	46	55	16	4	17	4	0.66	0.91
447	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(13), ACTN2(9), ACTN3(10), CAPN1(4), CAPNS1(3), CAPNS2(6), ITGA1(20), ITGB1(12), ITGB3(16), PTK2(11), PXN(6), SPTAN1(29), SRC(2), TLN1(28)	9938815	173	48	169	72	60	70	13	6	24	0	0.66	0.91
448	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	CRK(1), CXCL12(3), CXCR4(1), GNAI1(4), GNB1(3), MAP2K1(2), MAPK1(2), MAPK3(4), NFKB1(12), PIK3C2G(22), PLCG1(12), PRKCA(10), PTK2(11), PTK2B(16), PXN(6), RAF1(7), RELA(6)	7968738	122	42	120	49	31	41	21	10	17	2	0.66	0.91
449	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(7), SUCLA2(5)	754762	12	10	11	2	2	9	0	0	1	0	0.66	0.91
450	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(4), AASS(6), KARS(7)	1653641	23	16	22	10	7	7	6	2	1	0	0.67	0.91
451	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(17), CREM(5), FHL5(6), FSHR(17), GNAS(25), XPO1(15)	3133290	85	28	81	18	24	42	11	3	5	0	0.67	0.91
452	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(5), CFL1(1), GNAS(25), GNB1(3), LIMK1(7), MAP2K1(2), MAPK1(2), MAPK3(4), MYL2(1), NOX1(11), PIK3C2G(22), PLCB1(6), PPP1R12B(18), PRKCA(10), PTK2(11), RAF1(7), ROCK2(15)	8758155	150	44	147	41	40	52	21	8	25	4	0.67	0.91
453	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(11), DLL1(8), FURIN(5), PSEN1(4)	1751631	28	18	28	20	6	16	1	2	3	0	0.67	0.91
454	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(9), BFAR(9), BRAF(12), CAMP(1), CREB1(5), CREB3(2), CREB5(6), MAPK1(2), RAF1(7), SNX13(12), SRC(2), TERF2IP(4)	3966205	71	30	71	14	11	28	14	6	12	0	0.67	0.91
455	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(6), CD86(6), HLA-DRB1(1), IFNG(5), IFNGR1(6), IFNGR2(4), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18(1), IL18R1(5), IL2(4), IL2RA(3), IL4R(6)	4512559	84	33	82	19	20	35	9	8	12	0	0.68	0.92
456	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(12), NR0B2(2), NR1H3(5), NR1H4(8), RXRA(1)	1845319	31	21	31	11	8	16	4	0	3	0	0.68	0.92
457	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(9), CDC25B(3), CDC25C(8), CHEK1(4), WEE1(1), YWHAH(4)	2566621	29	20	26	6	6	10	3	0	10	0	0.68	0.92
458	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(9), IARS(13), LARS(23), LARS2(9), PDHA1(4), PDHA2(10), PDHB(7)	3562056	75	27	75	14	15	34	11	4	11	0	0.68	0.92
459	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(2), BLVRB(1), CP(12), CPOX(8), EPRS(11), FECH(5), GUSB(5), HCCS(2), HMBS(7), HMOX1(3), HMOX2(5), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10), UROD(2), UROS(3)	9137926	139	43	133	39	42	57	17	7	16	0	0.68	0.92
460	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(9), ACO1(13), ACO2(8), CLYBL(10), CS(5), DLD(7), DLST(10), FH(11), IDH1(4), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), OGDH(11), OGDHL(18), PC(8), PCK1(15), PCK2(7), SDHA(12), SDHB(1), SDHC(6), SDHD(1), SUCLA2(5), SUCLG1(1)	10165387	195	51	188	76	49	91	26	11	18	0	0.69	0.92
461	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	CALM2(3), CALM3(1), DLG4(13), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), NOS1(21), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), SYT1(4)	8451279	157	46	152	68	34	70	31	6	16	0	0.69	0.92
462	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(12), CLOCK(11), CRY1(6), CRY2(4), CSNK1E(10), NPAS2(10), NR1D1(3), PER1(15), PER2(8), PER3(16)	5595468	95	35	91	27	28	33	14	3	15	2	0.69	0.92
463	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(4), ARFGAP1(3), ARFGAP3(6), ARFGEF2(30), CLTA(1), CLTB(5), COPA(14), GBF1(23), GPLD1(10), KDELR1(3), KDELR2(2), KDELR3(4)	5507994	105	35	105	25	20	50	14	5	14	2	0.70	0.92
464	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(13), G6PD(3), GCLC(8), GCLM(3), GGT1(10), GPX3(4), GPX5(7), GSS(5), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), IDH1(4), IDH2(7), MGST1(3), MGST3(1), PGD(4)	6272794	109	40	104	41	41	36	14	11	5	2	0.70	0.92
465	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(4), CASP7(4), DFFA(1), DFFB(3), GZMB(2), HMGB1(2), HMGB2(3), TOP2A(15), TOP2B(21)	3519275	55	27	55	21	5	17	13	7	13	0	0.70	0.92
466	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	14	ACADL(7), ACADM(6), ACADS(5), ACADVL(6), ACSL1(13), ACSL3(10), CPT1A(10), CPT2(7), EHHADH(9), HADHA(7), PECR(5), SCP2(13), SLC25A20(5)	5312731	103	34	99	32	24	44	19	6	10	0	0.70	0.92
467	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(6), CBS(13), CTH(5), GGT1(10), HEMK1(2), LCMT1(4), LCMT2(13), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), METTL2B(3), METTL6(2), PAPSS1(6), PAPSS2(6), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SCLY(4), SEPHS1(13), SEPHS2(4), WBSCR22(9)	8352572	177	41	169	45	53	71	23	7	19	4	0.70	0.92
468	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(11), GTF2A1(5), GTF2B(5), GTF2E1(4), GTF2F1(6), HDAC3(10), NCOA1(17), NCOA2(16), NCOA3(8), NCOR2(24), POLR2A(25), RARA(3), RXRA(1), TBP(5)	8039721	140	41	137	55	27	68	23	7	15	0	0.70	0.92
469	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(4), GBA3(9), GGT1(10), SHMT1(6), SHMT2(8)	1968643	39	20	36	13	12	14	4	1	6	2	0.70	0.92
470	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(5), CALCRL(9), CD97(8), CRHR1(2), CRHR2(2), ELTD1(12), EMR1(22), EMR2(5), GHRHR(2), GIPR(4), GLP1R(8), GLP2R(17), GPR64(10), LPHN1(16), LPHN2(30), LPHN3(29), SCTR(4), VIPR1(3)	9426160	195	48	190	57	43	93	23	14	20	2	0.71	0.92
471	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	CDK5(1), CDK5R1(5), DRD1(6), DRD2(10), GRM1(22), PLCB1(6), PPP1CA(6), PPP1R1B(4), PPP2CA(6), PPP3CA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5)	5302454	91	33	89	36	24	38	13	4	12	0	0.71	0.92
472	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(1), LCT(30), MPI(5), PGM1(9), PYGL(9), PYGM(10), TPI1(1), TREH(4)	4675557	82	30	82	33	19	36	11	8	8	0	0.71	0.92
473	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPS(10), CDIPT(1), CDS1(3), CDS2(2), CHAT(1), CHKA(8), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), ETNK1(9), GNPAT(11), GPD1(6), GPD2(5), LCAT(2), LGALS13(2), LYPLA1(2), LYPLA2(5), PAFAH1B1(1), PAFAH2(6), PCYT1A(7), PCYT1B(4), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB2(9), PLCG1(12), PLCG2(27), PPAP2A(4), PPAP2B(3)	16172413	282	62	278	93	74	108	44	21	31	4	0.71	0.92
474	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(4), BIRC3(3), FADD(1), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	2309696	31	19	31	9	6	11	5	3	6	0	0.72	0.92
475	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(13), ACO2(8), CS(5), GRHPR(4), HAO1(2), HAO2(7), HYI(2), MDH1(2), MDH2(5), MTHFD1(6), MTHFD1L(12), MTHFD2(3)	4485313	69	33	68	28	24	26	9	5	5	0	0.72	0.92
476	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), LTB4R(3), P2RY1(2), P2RY2(6), P2RY6(3)	2001147	32	21	32	14	9	9	10	4	0	0	0.72	0.92
477	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	19	APAF1(19), ARHGDIB(2), BIRC2(13), BIRC3(3), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP9(3), CYCS(3), DFFA(1), DFFB(3), GZMB(2), LMNA(8), LMNB1(5), PRF1(8)	6020888	116	35	111	34	35	42	16	4	19	0	0.72	0.92
478	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	6	CHRM1(6), GNB1(3), PLCB1(6), TUB(12)	2144786	27	19	27	10	9	11	5	0	2	0	0.72	0.92
479	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	11	ACTN1(13), ACTN2(9), ACTN3(10), CSK(1), CTNNA1(18), CTNNA2(13), PTK2(11), PXN(6), SRC(2), VCL(14)	6059606	97	36	92	43	32	36	9	2	18	0	0.72	0.92
480	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(4), CRK(1), CRKL(5), DOCK1(32), ELK1(2), FOS(6), GAB1(10), GRB2(3), HGF(15), ITGA1(20), ITGB1(12), JUN(1), MAP2K1(2), MAP4K1(13), MAPK1(2), MAPK3(4), MAPK8(7), MET(10), PAK1(3), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAF1(7), RAP1A(3), RAP1B(2), SOS1(21), SRC(2), STAT3(12)	13119427	240	60	234	74	61	103	32	10	32	2	0.72	0.92
481	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	CASP3(4), CFL1(1), CFLAR(7), PDE6D(1)	884539	13	11	13	4	2	7	2	1	1	0	0.72	0.92
482	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(12), ACY3(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH7A1(2), ALDH9A1(4), AMDHD1(9), AOC2(6), AOC3(14), ASPA(5), CARM1(6), CNDP1(6), DDC(11), HAL(6), HARS(4), HARS2(8), HDC(10), HEMK1(2), HNMT(5), LCMT1(4), LCMT2(13), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), PRPS1(3), PRPS2(10), UROC1(14), WBSCR22(9)	13349823	263	53	257	73	72	99	37	15	36	4	0.72	0.92
483	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	10	ABL1(9), CDKN2A(1), MDM2(6), MYC(7), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), TBX2(4)	4470734	64	31	63	36	18	26	5	7	8	0	0.72	0.92
484	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(8), AKT2(4), AKT3(8), BCR(6), BTK(11), CD19(7), CDKN2A(1), DAPP1(7), FLOT1(1), FLOT2(3), GAB1(10), ITPR1(31), ITPR2(38), ITPR3(23), LYN(7), NR0B2(2), PDK1(7), PHF11(4), PLCG2(27), PPP1R13B(7), PREX1(25), PTPRC(15), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SAG(5), SYK(6), TEC(5), VAV1(16)	18132213	325	67	314	117	78	143	42	16	42	4	0.72	0.92
485	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	23	ARHGDIB(2), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CFLAR(7), DAXX(11), DFFA(1), DFFB(3), FADD(1), FAF1(8), JUN(1), LMNA(8), LMNB1(5), MAP2K4(6), MAP3K7(8), MAPK8(7), PAK1(3), PAK2(6), PRKDC(70), PTPN13(27), RIPK2(7), SPTAN1(29)	12602470	232	53	228	51	58	86	35	15	33	5	0.73	0.92
486	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(9), ALG10B(8), ALG11(6), ALG12(1), ALG13(17), ALG14(2), ALG2(2), ALG3(5), ALG5(4), ALG6(5), ALG8(8), ALG9(6), B4GALT1(2), B4GALT2(5), B4GALT3(8), DAD1(1), DDOST(3), DHDDS(8), DOLPP1(1), DPAGT1(4), DPM1(2), FUT8(13), GANAB(13), MAN1A1(11), MAN1A2(9), MAN1B1(4), MAN1C1(7), MAN2A1(23), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), MGAT5B(7), RFT1(6), RPN1(6), RPN2(9), ST6GAL1(10), STT3B(6)	14360076	262	58	245	64	65	109	41	9	34	4	0.73	0.92
487	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	259076	5	3	5	2	1	3	0	1	0	0	0.73	0.92
488	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(37), RANGAP1(5)	2882340	43	23	43	7	9	14	9	1	10	0	0.73	0.92
489	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(7), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT5(2), FUT8(13), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4)	2606056	53	25	48	17	15	25	9	0	4	0	0.73	0.92
490	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMC3(1), PSMD14(3), RPN1(6), RPN2(9), UBE2A(4), UBE3A(13)	4635883	75	30	71	24	14	32	11	3	15	0	0.74	0.92
491	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(12), ALAS2(11), BLVRA(2), BLVRB(1), COX10(5), COX15(4), CP(12), CPOX(8), EARS2(4), EPRS(11), FECH(5), FTH1(2), FTMT(7), GUSB(5), HCCS(2), HMBS(7), HMOX1(3), HMOX2(5), MMAB(2), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), UROD(2), UROS(3)	13992494	264	53	254	65	79	107	38	13	27	0	0.74	0.92
492	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(11), AASDHPPT(4), AASS(6), KARS(7)	2455008	34	22	33	16	12	9	8	2	3	0	0.74	0.92
493	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(12), ACADL(7), ACADM(6), ACADSB(4), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), AOC2(6), AOC3(14), CNDP1(6), DPYD(16), DPYS(3), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), MLYCD(5), SDS(3), SMS(8), UPB1(9)	10047799	183	49	178	64	52	63	29	15	24	0	0.74	0.92
494	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	60	AKT1(8), AKT2(4), AKT3(8), BAD(2), CASP9(3), CDC42(5), KDR(23), MAP2K1(2), MAPK1(2), MAPK13(2), MAPK14(6), MAPK3(4), MAPKAPK2(6), MAPKAPK3(4), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NOS3(11), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKCA(10), PRKCG(10), PTGS2(7), PTK2(11), PXN(6), RAC2(2), RAF1(7), SPHK1(2), SPHK2(1), SRC(2), VEGFA(1)	21132619	368	71	361	127	105	143	48	23	49	0	0.74	0.92
495	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), AKR1B10(4), ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), FPGT(5), FUK(8), GMDS(3), GMPPA(9), GMPPB(3), HK1(13), HK2(8), HK3(12), HSD3B7(3), KHK(1), LHPP(2), MPI(5), MTMR1(16), MTMR2(4), MTMR6(8), PFKFB1(9), PFKFB2(1), PFKFB3(7), PFKFB4(4), PFKM(7), PFKP(11), PGM2(6), PHPT1(2), PMM1(1), PMM2(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SORD(3), TPI1(1), TSTA3(4)	12021700	208	55	202	71	56	86	25	14	25	2	0.74	0.92
496	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(6), ALDOB(9), ALDOC(4), DERA(9), FBP1(4), G6PD(3), GPI(9), H6PD(5), PFKM(7), PFKP(11), PGD(4), PGLS(1), PGM1(9), PGM3(6), PRPS1(3), PRPS1L1(5), PRPS2(10), RBKS(1), RPE(3), RPIA(7), TALDO1(6), TKT(7), TKTL1(10), TKTL2(12)	7865729	151	45	143	50	40	67	17	8	17	2	0.75	0.92
497	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CAMKK1(8), CAMKK2(6), CREB1(5), SYT1(4)	3825434	71	30	69	11	16	31	7	4	13	0	0.75	0.92
498	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(9), CYP51A1(4), DHCR24(6), DHCR7(4), FDFT1(3), FDPS(7), GGCX(10), GGPS1(2), HMGCR(15), HSD17B7(4), IDI1(4), IDI2(2), MVD(3), MVK(7), NQO1(3), NSDHL(9), PMVK(2), SC4MOL(3), SC5DL(3), SQLE(6), TM7SF2(3), VKORC1(3)	6305059	112	34	111	49	31	42	17	8	14	0	0.75	0.92
499	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7)	2015487	42	21	41	7	11	15	10	0	6	0	0.75	0.92
500	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(5), ALG5(4), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT5(2), DDOST(3), DPAGT1(4), DPM1(2), FUT8(13), MAN1A1(11), MAN1B1(4), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), RPN1(6), RPN2(9), ST6GAL1(10)	6557682	117	37	109	31	36	46	20	2	13	0	0.76	0.92
501	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(4), ARF3(2), CDK2(5), CDK4(4), CDKN1A(1), CDKN1B(5), CDKN2A(1), CFL1(1), E2F2(1), MDM2(6), PRB1(4)	2112760	34	19	34	15	6	13	9	3	3	0	0.76	0.92
502	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(7), GGPS1(2), IDI1(4), IDI2(2), SQLE(6)	1516694	24	16	24	10	6	8	5	3	2	0	0.76	0.92
503	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(4), ACSS2(11), ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH7A1(2), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), G6PC2(9), GAPDH(2), GAPDHS(10), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGAM2(2), PGK1(6), PGK2(5), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	19211776	325	62	318	106	97	131	42	20	31	4	0.76	0.92
504	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(5), ASNS(9), CA1(4), CA12(3), CA14(4), CA2(5), CA3(4), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(5), CA8(5), CA9(8), CPS1(24), CTH(5), GLS(10), GLS2(9), GLUD1(4), GLUL(6), HAL(6)	6613130	129	39	123	36	42	47	15	4	17	4	0.76	0.92
505	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(1), MRPS7(6), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL14(2), RPL18(4), RPL18A(4), RPL19(4), RPL21(2), RPL22L1(3), RPL23A(3), RPL24(3), RPL27(1), RPL27A(1), RPL28(2), RPL29(3), RPL3(5), RPL30(2), RPL31(1), RPL35(1), RPL35A(2), RPL36A(1), RPL36AL(1), RPL37(3), RPL38(1), RPL3L(3), RPL6(2), RPL7(2), RPL8(1), RPL9(1), RPS10(2), RPS12(3), RPS13(1), RPS15A(1), RPS18(4), RPS20(3), RPS21(2), RPS24(4), RPS25(1), RPS27(2), RPS29(2), RPS3(2), RPS3A(2), RPS5(1), RPS6(6), RPS7(3), RPS8(5), RPS9(1), RPSA(1)	7470184	125	40	122	38	28	61	21	2	13	0	0.76	0.92
506	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	9	CDC25A(9), CDC25B(3), CDC25C(8), CDK2(5), CDK4(4), CHEK1(4), WEE1(1), YWHAH(4)	3012356	38	22	35	9	7	14	6	1	10	0	0.76	0.92
507	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), CDC42(5), WASF1(3), WASL(8)	2884252	44	23	44	13	15	18	2	0	9	0	0.76	0.92
508	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(12), CSF1(5), FCGR3A(2), IL1B(2), IL6R(12), SELL(4), SPN(4), TGFB1(4), TGFB2(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(8), TNFSF8(1)	4599794	84	30	81	21	26	28	16	4	10	0	0.76	0.92
509	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(7), FOS(6), FYN(7), JUN(1), MAPK14(6), THBS1(12)	2603188	43	22	43	11	12	18	4	4	5	0	0.76	0.92
510	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(7), NFYB(2), NFYC(1), SP1(6), SP3(12)	1727970	28	18	26	8	2	14	7	1	4	0	0.77	0.92
511	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(5), ACOT11(6), ACYP1(2), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ECHS1(3), EHHADH(9), ESCO1(11), ESCO2(6), GCDH(5), HADHA(7), ITGB1BP3(1), NAT6(2), PNPLA3(6), SH3GLB1(8), YOD1(2)	8986878	101	39	101	38	27	46	13	4	11	0	0.77	0.93
512	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	39	ACTR2(7), ACTR3(3), AKT1(8), AKT2(4), AKT3(8), ANGPTL2(9), ARHGAP1(2), ARHGAP4(15), ARHGEF11(22), BTK(11), CDC42(5), CFL1(1), CFL2(8), GDI1(4), GDI2(3), ITPR1(31), ITPR2(38), ITPR3(23), LIMK1(7), MYLK(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDK1(7), PIK3CD(10), PIK3CG(25), PPP1R13B(7), RACGAP1(8), RHO(8), ROCK1(27), ROCK2(15), RPS4X(4), SAG(5), WASF1(3), WASL(8)	21959798	400	70	390	118	118	161	45	17	53	6	0.77	0.93
513	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	58	CCNA1(4), CCNB1(8), CCND2(7), CCND3(5), CCNE2(6), CCNG2(4), CCNH(3), CDC25A(9), CDK2(5), CDK4(4), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), CREB3(2), CREB3L1(6), CREB3L3(9), CREB3L4(8), E2F2(1), E2F3(5), E2F4(3), E2F5(1), E2F6(3), GBA2(13), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), MNAT1(2), MYC(7), NACA(20), PCNA(3), POLE(1), POLE2(4), PRIM1(2), RBL1(17), RPA1(6), RPA2(2), RPA3(4), TFDP2(8), TNXB(25), WEE1(1)	22908150	287	59	280	81	80	128	31	18	30	0	0.77	0.93
514	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(8), CS(5), DLAT(2), DLD(7), DLST(10), FH(11), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), OGDH(11), PC(8), PDHA1(4), PDHA2(10), PDHB(7), PDHX(8), PDK1(7), PDK2(5), PDK3(10), PDK4(7), PDP2(7), SDHA(12), SDHB(1), SDHC(6), SDHD(1), SUCLA2(5), SUCLG1(1)	9549723	186	47	181	66	53	82	21	11	19	0	0.77	0.93
515	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1C1(5), AKR1C2(3), AKR1C3(3), AKR1C4(5), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), CYP1A1(9), CYP1A2(6), CYP1B1(3), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2F1(5), CYP2S1(8), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), DHDH(3), EPHX1(2), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTA5(2), GSTK1(5), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), MGST1(3), MGST3(1), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10)	19472525	384	66	369	86	106	161	61	20	36	0	0.78	0.93
516	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	28	ABP1(12), ACY1(3), ADC(8), AGMAT(3), ALDH18A1(13), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AMD1(3), AOC2(6), AOC3(14), ARG1(5), ARG2(6), ASL(4), ASS1(3), CPS1(24), GATM(8), MAOA(14), MAOB(7), ODC1(3), OTC(8), SMS(8), SRM(1)	9880977	176	46	170	64	50	74	22	8	18	4	0.78	0.93
517	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1C4(5), AKR1D1(8), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), BAAT(7), CEL(6), CYP27A1(8), CYP7A1(12), HADHB(5), SOAT2(8), SRD5A1(4), SRD5A2(4)	8060036	152	42	147	43	47	55	25	8	17	0	0.78	0.93
518	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(13), ACO2(8), ACSS1(4), ACSS2(11), FH(11), IDH1(4), IDH2(7), MDH1(2), MDH2(5), SUCLA2(5)	4691092	79	32	78	36	22	35	6	7	7	2	0.79	0.93
519	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(2), ACAT1(6), ACAT2(5), ECHS1(3), EHHADH(9), HADHA(7), HADHB(5), SDS(3)	2850075	45	22	45	13	10	20	8	5	2	0	0.79	0.94
520	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(6), SNAP25(7), STX1A(2)	1149112	21	17	20	7	8	7	4	1	1	0	0.79	0.94
521	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(7), ACADM(6), ACADS(5), ACAT1(6), ECHS1(3), HADHA(7)	1813293	34	18	33	14	3	20	5	3	3	0	0.80	0.94
522	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(3), HADH(1), HADHA(7), HADHB(5), HSD17B10(4), HSD17B4(10), MECR(6), PPT1(6), PPT2(3)	2893812	47	23	45	11	6	24	7	6	4	0	0.80	0.94
523	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(14), ACE2(19), AGT(7), AGTR2(8), ANPEP(13), CMA1(1), CPA3(5), CTSA(7), CTSG(3), ENPEP(13), LNPEP(9), MAS1(2), MME(8), NLN(4), REN(3)	7026122	116	38	112	47	36	38	18	6	14	4	0.80	0.94
524	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), CSF3(1), EPO(2), FLT3(9), IGF1(3), IL1A(1), IL6(2), KITLG(2), TGFB1(4), TGFB2(6), TGFB3(9)	2884730	40	22	40	13	10	18	4	1	7	0	0.80	0.94
525	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	7	IFNAR1(9), IFNAR2(8), IFNB1(4), STAT1(14), STAT2(12), TYK2(7)	2969097	54	25	51	17	14	21	11	4	4	0	0.80	0.94
526	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(27), ACACB(31), ACAT1(6), ACAT2(5), ACOT12(10), ACSS1(4), ACSS2(11), ACYP1(2), AKR1B1(2), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), DLAT(2), DLD(7), GRHPR(4), HAGH(2), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), LDHD(3), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PC(8), PCK1(15), PCK2(7), PDHA1(4), PDHA2(10), PDHB(7), PKLR(10), PKM2(5)	15880833	257	60	249	91	70	107	30	11	35	4	0.81	0.94
527	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	20	ASAH1(9), CAMP(1), CASP3(4), CERK(8), CREB1(5), CREB3(2), CREB5(6), CXCL2(2), DAG1(7), EPHB2(10), FOS(6), ITPKB(6), JUN(1), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7)	6359790	103	34	101	38	29	42	8	3	19	2	0.81	0.94
528	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(3), CD3E(2), CD3G(2), CXCR3(5), ETV5(10), IFNG(5), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18(1), IL18R1(5), JAK2(21), JUN(1), MAP2K6(9), MAPK14(6), MAPK8(7), STAT4(9), TYK2(7)	6381539	130	36	127	25	26	50	17	14	17	6	0.81	0.94
529	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(6), ALOX15(12), ALOX15B(12), ALOX5(7), ALOX5AP(4), GGT1(10), LTA4H(6), PLA2G6(6), PTGDS(6), PTGES(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6)	4640424	100	32	98	26	27	47	13	3	10	0	0.81	0.94
530	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CYP2C19(7), CYP2C9(5), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ECHS1(3), EHHADH(9), ESCO1(11), ESCO2(6), HADHA(7), NAT6(2), PNPLA3(6), SH3GLB1(8), YOD1(2)	10656293	117	40	116	47	40	48	11	6	12	0	0.81	0.94
531	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(5), ACADL(7), ACADM(6), ACOX1(4), ACOX2(7), ACOX3(8), ACSL1(13), ACSL3(10), ACSL5(18), ACSL6(13), ADIPOQ(3), ANGPTL4(1), APOA2(2), APOA5(2), AQP7(6), CD36(7), CPT1A(10), CPT1C(15), CPT2(7), CYP27A1(8), CYP4A11(5), CYP4A22(8), CYP7A1(12), CYP8B1(8), DBI(3), EHHADH(9), FABP1(5), FABP2(1), FABP3(1), FABP5(3), FABP6(3), FABP7(2), FADS2(2), GK(14), GK2(20), HMGCS2(8), ILK(8), LPL(11), ME1(10), MMP1(2), NR1H3(5), OLR1(1), PCK1(15), PCK2(7), PDPK1(3), PLTP(6), PPARA(2), PPARD(6), PPARG(5), RXRA(1), RXRG(10), SCD(9), SCP2(13), SLC27A1(9), SLC27A2(4), SLC27A4(5), SLC27A5(6), SLC27A6(10), SORBS1(22), UBC(5), UCP1(1)	22088619	432	72	419	120	124	181	59	21	45	2	0.81	0.94
532	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(17), CALM2(3), CALM3(1), CREB1(5), ELK1(2), FOS(6), GNAI1(4), GNAS(25), GNB1(3), JUN(1), MAP2K1(2), MAPK3(4), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PRKCA(10), RAF1(7), RPS6KA3(17), SYT1(4)	11338160	196	50	189	59	56	75	23	14	28	0	0.81	0.94
533	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), RPE(3), UCHL1(5), UCHL3(1), UGDH(3), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10)	5675055	89	33	85	16	31	32	12	5	9	0	0.82	0.94
534	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(4), ATG5(3), ATG7(6), GABARAP(2), GABARAPL1(2), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNG(5), PIK3C3(11), PIK3R4(25), PRKAA1(6), PRKAA2(9), ULK2(10), ULK3(5)	6746014	119	37	118	37	32	49	19	7	12	0	0.82	0.94
535	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	6	CCNA1(4), CDK2(5), CUL1(12), SKP2(6)	2046796	27	17	27	4	5	14	6	0	2	0	0.82	0.95
536	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(19), PDXK(3), PDXP(1), PNPO(4), PSAT1(5)	1614923	32	18	32	11	10	12	5	1	4	0	0.82	0.95
537	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(5), GTF2A1L(2), GTF2B(5), GTF2E1(4), GTF2E2(5), GTF2F1(6), GTF2F2(1), GTF2H1(8), GTF2H2(3), GTF2H3(3), GTF2H4(2), GTF2I(5), GTF2IRD1(15), STON1(2), TAF1(40), TAF10(1), TAF12(1), TAF1L(41), TAF2(17), TAF4(7), TAF4B(11), TAF5(6), TAF5L(4), TAF6(8), TAF6L(8), TAF7(3), TAF7L(10), TAF9(2), TBPL1(4), TBPL2(4)	12706674	233	48	229	66	58	101	34	11	27	2	0.83	0.95
538	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(2), ACAD8(7), ACAD9(10), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1B10(4), AKR1C4(5), AKR1D1(8), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), BAAT(7), CEL(6), CYP27A1(8), CYP7A1(12), HADHB(5), HSD3B7(3), LIPA(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SLC27A5(6), SOAT1(10), SOAT2(8), SRD5A1(4), SRD5A2(4)	10858009	205	48	200	50	60	80	31	10	22	2	0.83	0.95
539	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(19), CD38(7), ENPP1(11), ENPP3(16), NADSYN1(12), NMNAT1(4), NMNAT2(2), NNMT(7), NNT(9), NT5C(1), NT5E(6), NT5M(4)	5019239	98	34	94	20	22	43	20	7	6	0	0.83	0.95
540	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), FPGT(5), GCK(5), GMDS(3), GMPPA(9), GMPPB(3), HK1(13), HK2(8), HK3(12), KHK(1), MPI(5), PFKFB1(9), PFKFB3(7), PFKFB4(4), PFKM(7), PFKP(11), PMM1(1), PMM2(6), SORD(3), TPI1(1)	8193876	138	43	135	46	39	60	14	11	12	2	0.83	0.95
541	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(12), AZIN1(3), CBX3(5), CLOCK(11), CRY1(6), CRY2(4), DAZAP2(2), DNAJA1(1), EIF4G2(8), ETV6(9), GFRA1(6), GSTM3(4), GSTP1(2), HERPUD1(1), HSPA8(10), IDI1(4), KLF9(3), MYF6(8), NCKAP1(10), NCOA4(12), NR1D2(5), PER1(15), PER2(8), PIGF(4), PPP1R3C(3), PPP2CB(2), PSMA4(2), SF3A3(6), SUMO3(3), TOB1(2), UCP3(1), UGP2(8), VAPA(5), ZFR(13)	12390477	198	49	193	60	49	84	26	10	26	3	0.84	0.96
542	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(5)	721302	12	8	12	4	5	6	0	0	1	0	0.84	0.96
543	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CDK2(5), CDKN1B(5), CUL1(12), RBX1(1), SKP2(6), UBE2M(1)	2123515	30	17	30	5	4	18	6	0	2	0	0.85	0.96
544	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(12), AGMAT(3), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH4A1(2), ALDH9A1(4), AMD1(3), AOC2(6), AOC3(14), ARG1(5), ARG2(6), ASL(4), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), DAO(5), GATM(8), GLUD1(4), GOT1(6), GOT2(5), MAOA(14), MAOB(7), NOS1(21), NOS3(11), OAT(7), ODC1(3), OTC(8), P4HA1(8), P4HA2(10), P4HA3(5), P4HB(1), RARS(11), SMS(8)	14375611	272	54	264	88	70	117	35	17	29	4	0.85	0.96
545	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(7), ASAH1(9), B4GALT6(5), CERK(8), DEGS1(5), DEGS2(4), ENPP7(3), GAL3ST1(13), GALC(7), GBA(4), GLA(3), GLB1(9), LCT(30), NEU2(5), NEU3(3), PPAP2A(4), PPAP2B(3), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(3), SMPD1(12), SMPD2(5), SMPD3(6), SMPD4(16), SPHK1(2), SPHK2(1), SPTLC1(6), SPTLC2(6), UGCG(5), UGT8(12)	11178269	216	50	213	62	70	88	18	12	28	0	0.85	0.96
546	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(7), APOBEC2(5), APOBEC3A(2), APOBEC3B(8), APOBEC3C(5), APOBEC3F(6), APOBEC3G(4), APOBEC4(4)	2589565	47	24	47	18	12	22	9	1	1	2	0.85	0.96
547	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(2), TGDS(3), UGDH(3), UXS1(5)	1422050	15	13	15	9	5	4	4	1	1	0	0.86	0.97
548	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(15), CALM2(3), CALM3(1), CAPN2(6), CAPNS1(3), CAPNS2(6), EP300(29), HDAC1(4), HDAC2(5), MEF2D(7), NFATC2(15), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), SYT1(4)	8113333	125	37	123	44	29	45	20	7	22	2	0.86	0.97
549	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), HEMK1(2), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), WBSCR22(9)	5012547	101	30	99	23	27	41	10	5	14	4	0.87	0.97
550	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(7), IL22RA1(2), IL22RA2(1), JAK2(21), JAK3(9), STAT1(14), STAT3(12), STAT5A(5), STAT5B(5), TYK2(7)	5454458	83	32	81	35	16	42	10	4	5	6	0.87	0.97
551	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(4), CCNA2(3), CCNE2(6), CDK2(5), CDK4(4), CDKN1B(5), CDKN2A(1), E2F2(1), E2F4(3), PRB1(4)	2533400	36	19	35	9	5	12	11	3	5	0	0.87	0.97
552	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(5), DAB1(7), FYN(7), LRP8(3), RELN(48), VLDLR(6)	4995100	77	31	75	35	22	27	16	3	7	2	0.87	0.97
553	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(6), CYP2E1(5), NR1I3(7), PTGS1(8), PTGS2(7)	1873760	33	18	32	8	9	12	3	2	7	0	0.88	0.97
554	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), G6PD(3), GPI(9), H6PD(5), PFKM(7), PFKP(11), PGD(4), PGLS(1), PGM1(9), PGM3(6), PRPS1(3), PRPS1L1(5), PRPS2(10), RBKS(1), RPE(3), RPIA(7), TAL1(1), TALDO1(6), TKT(7)	6914987	121	38	116	42	34	53	15	7	10	2	0.88	0.97
555	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), HEMK1(2), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PCYT1A(7), PCYT1B(4), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), WBSCR22(9)	4773069	90	29	88	21	24	36	10	5	11	4	0.88	0.97
556	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), CDC42(5), PAK1(3), PDGFRA(29), WASL(8)	3420329	69	22	67	10	20	27	8	2	10	2	0.88	0.97
557	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), CDK5R1(5), DPM2(4), EGR1(8), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(4), NGFR(4), RAF1(7)	2632824	39	23	39	16	12	15	6	3	3	0	0.88	0.97
558	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(19), BAK1(4), BAX(4), BCL2L1(3), BID(3), BIK(1), BIRC2(13), BIRC3(3), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CYCS(3), DFFA(1), DFFB(3), DIABLO(2)	4185368	74	26	72	23	17	25	14	4	14	0	0.88	0.97
559	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(6), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), IDS(6), LCT(30), NAGLU(3)	4640424	68	31	68	29	20	30	8	5	5	0	0.88	0.97
560	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(8), ADCY9(25), AK1(2), ARF1(4), ARF3(2), ARF4(3), ARF5(5), ARF6(2), ARL4D(1), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ERO1L(6), GNAS(25), PDIA4(4), PLCG1(12), PLCG2(27), PRKCA(10), SEC61A1(3), SEC61A2(6), SEC61B(1), SEC61G(3), TRIM23(12)	12614420	253	53	247	72	73	112	24	11	31	2	0.88	0.97
561	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(11), CYCS(3), GPD2(5), NDUFA1(1), SDHA(12), SDHB(1), SDHC(6), SDHD(1), UQCRC1(6)	2329533	46	20	46	9	10	24	6	3	3	0	0.89	0.97
562	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(4), CCR3(5), HLA-DRB1(1), IL5(2)	1083387	12	9	12	2	2	4	2	0	4	0	0.89	0.97
563	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(9), CHST12(5), PAPSS1(6), PAPSS2(6), SULT1A1(8), SULT1A2(2), SULT1E1(13), SULT2A1(7), SULT2B1(4), SUOX(4)	3175354	65	26	61	26	19	32	8	2	4	0	0.90	0.98
564	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	12	BLVRA(2), BLVRB(1), HMOX1(3), IL10(4), IL10RA(7), IL10RB(9), IL1A(1), IL6(2), STAT1(14), STAT3(12), STAT5A(5), TNF(1)	3418178	61	25	60	22	17	30	6	0	8	0	0.90	0.98
565	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(8), HLCS(5), SPCS1(1), SPCS3(3)	1059965	17	11	17	13	6	5	4	0	2	0	0.90	0.98
566	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(37), DAXX(11), PAX3(4), PML(10), RARA(3), SIRT1(8), SP100(15), TNF(1), TNFRSF1A(6), TNFRSF1B(3)	5462106	98	31	96	27	27	44	11	3	13	0	0.91	0.98
567	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(9), BCAT2(6), IARS(13), IARS2(21), ILVBL(7), LARS(23), LARS2(9), PDHA1(4), PDHA2(10), PDHB(7), VARS(8), VARS2(5)	6538801	122	34	121	25	31	55	15	6	15	0	0.91	0.98
568	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(6), FOS(6), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(4), MYC(7), NFKB1(12), NFKBIA(3), PLCB1(6), PRKCA(10), RAF1(7), RELA(6), TNF(1)	5383714	73	31	73	20	12	27	18	9	7	0	0.91	0.98
569	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(3), CALM3(1), CDKN1A(1), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), SP1(6), SP3(12), SYT1(4)	6970913	101	36	97	42	30	36	16	5	14	0	0.91	0.98
570	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), DHFR(3), FPGS(3), GCH1(2), GGH(3), SPR(2)	2019311	28	19	28	10	8	15	2	3	0	0	0.91	0.98
571	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(5), ALDOA(6), ALDOB(9), ALDOC(4), TPI1(1)	1383093	25	14	24	6	7	9	3	2	2	2	0.91	0.98
572	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(27), ACAT1(6), ACAT2(5), ACYP1(2), ADH5(3), AKR1B1(2), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), DLAT(2), DLD(7), GRHPR(4), HAGH(2), LDHA(6), LDHB(2), LDHC(3), LDHD(3), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PC(8), PCK1(15), PDHA1(4), PDHA2(10), PDHB(7), PKLR(10), PKM2(5)	12406490	200	51	197	71	52	82	25	10	31	0	0.92	0.98
573	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(4), CAPN1(4), CAPN2(6), CAPNS1(3), CAPNS2(6), CXCR3(5), EGF(24), EGFR(20), ITGA1(20), ITGB1(12), MAPK1(2), MAPK3(4), MYL2(1), MYLK(17), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR2A(4), PRKAR2B(5), PTK2(11), PXN(6), TLN1(28)	11322864	194	46	187	62	55	80	23	7	29	0	0.92	0.98
574	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(5), MDH1(2), ME1(10), PC(8), PDHA1(4), SLC25A1(2), SLC25A11(2)	3162448	42	22	42	27	7	21	6	3	5	0	0.92	0.98
575	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	51	ALG2(2), BAK1(4), BAX(4), BFAR(9), BTK(11), CAD(38), CASP10(10), CASP3(4), CASP8AP2(18), CDK2AP1(1), CSNK1A1(5), DAXX(11), DEDD(1), DEDD2(2), DFFA(1), DIABLO(2), EGFR(20), EPHB2(10), FADD(1), FAF1(8), FAIM2(2), IL1A(1), IL8(3), MAP2K4(6), MAP3K5(21), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7), MET(10), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(3), PTPN13(27), RALBP1(7), RIPK1(8), ROCK1(27), SMPD1(12), TPX2(14), TRAF2(5), TUFM(13)	22443773	403	70	391	108	91	173	58	15	58	8	0.92	0.98
576	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB10(3), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMB8(3), PSMB9(1)	3051313	46	22	43	12	9	20	7	2	8	0	0.92	0.98
577	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(13), HSD17B1(3), HSD17B2(3), HSD17B3(6), HSD17B4(10), HSD17B7(4), HSD3B1(1), HSD3B2(5)	2838125	48	23	45	20	13	23	5	1	6	0	0.92	0.98
578	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(7), GOSR1(1), SEC22B(1), SNAP23(2), SNAP25(7), SNAP29(2), STX10(1), STX11(3), STX12(3), STX16(1), STX17(3), STX18(2), STX3(8), STX4(6), STX5(6), STX6(4), STX7(4), STX8(4), TSNARE1(5), USE1(4), VAMP1(1), VAMP4(2), VAMP8(1), VTI1B(9), YKT6(6)	5730264	95	33	92	31	26	40	13	3	11	2	0.92	0.98
579	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	35	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), ELK1(2), FPR1(4), GNA15(1), GNB1(3), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAPK1(2), MAPK14(6), MAPK3(4), NCF1(5), NCF2(6), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKBIA(3), PAK1(3), PIK3C2G(22), PLCB1(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), RAF1(7), RELA(6), SYT1(4)	11987045	185	47	183	50	51	60	33	9	30	2	0.93	0.98
580	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(19), BST1(5), CD38(7), ENPP1(11), ENPP3(16), NADK(4), NADSYN1(12), NMNAT1(4), NMNAT2(2), NMNAT3(2), NNMT(7), NNT(9), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT12(2)	7422623	138	39	132	36	35	54	31	12	6	0	0.93	0.98
581	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(5), ACYP1(2), ECHS1(3), EHHADH(9), GCDH(5), HADHA(7), SDHB(1), SDS(3)	2646208	41	21	41	15	9	20	6	4	2	0	0.93	0.98
582	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AGK(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), AKR1A1(1), AKR1B1(2), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CEL(6), DAK(8), DGAT2(4), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), GK(14), GK2(20), GLA(3), GLB1(9), GPAM(7), LCT(30), LIPA(6), LIPC(8), LIPF(7), LIPG(6), LPL(11), MGLL(6), PNLIP(3), PNLIPRP1(4), PNLIPRP2(8), PNPLA3(6), PPAP2A(4), PPAP2B(3)	19553307	380	62	370	108	106	157	58	23	34	2	0.93	0.98
583	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(1)	575512	6	5	6	2	3	1	1	0	1	0	0.93	0.98
584	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(19), BAD(2), BAK1(4), BAX(4), BCL10(2), BCL2L1(3), BCL2L11(4), BID(3), CASP8AP2(18), CASP9(3), CES1(12)	3983652	74	27	73	22	18	26	18	4	8	0	0.93	0.98
585	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(11), AASDHPPT(4), AASS(6), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), ATP6V0C(2), BBOX1(4), DLST(10), DOT1L(8), ECHS1(3), EHHADH(9), EHMT2(6), GCDH(5), HADHA(7), PLOD1(4), PLOD2(16), PLOD3(11), SDS(3), SHMT1(6), SHMT2(8), TMLHE(5)	12013813	181	46	178	53	53	61	29	14	20	4	0.93	0.98
586	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(7), AGTR2(8), BDKRB2(9), KNG1(8), NOS3(11), REN(3)	3061590	60	24	57	21	19	28	6	2	5	0	0.94	0.98
587	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AKR1A1(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), CEL(6), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), GK(14), GLA(3), GLB1(9), LCT(30), LIPC(8), LIPF(7), LIPG(6), LPL(11), PNLIP(3), PNLIPRP1(4), PNLIPRP2(8), PPAP2A(4), PPAP2B(3)	15873185	300	56	295	89	83	120	49	17	29	2	0.94	0.98
588	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(12), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), AOC2(6), AOC3(14), ASPA(5), CNDP1(6), DDC(11), HAL(6), HARS(4), HDC(10), HNMT(5), MAOA(14), MAOB(7), PRPS1(3), PRPS2(10)	8577710	162	38	158	55	44	63	21	10	24	0	0.94	0.98
589	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(5), ACOX1(4), ACOX3(8), ELOVL2(5), ELOVL5(4), ELOVL6(3), FADS1(5), FADS2(2), HADHA(7), HSD17B12(4), PECR(5), SCD(9)	3716450	61	24	61	18	16	27	8	4	6	0	0.94	0.98
590	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), RPE(3), UGDH(3), UGP2(8), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), XYLB(9)	8802370	178	39	169	36	59	64	30	8	17	0	0.94	0.98
591	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(1), CHKA(8), PCYT1A(7), PDHA1(4), PDHA2(10), PEMT(2)	2379723	36	19	36	13	12	11	6	3	4	0	0.94	0.98
592	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(2), TGDS(3), UGDH(3), UGP2(8), UXS1(5)	1796563	23	15	22	10	9	7	5	1	1	0	0.94	0.98
593	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	ASAH1(9), CAMP(1), DAG1(7), ITPKB(6)	1846275	23	18	23	13	8	11	1	0	3	0	0.94	0.98
594	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(20), EGF(24), EGFR(20), RAB5A(2), TF(15), TFRC(6)	4485074	87	28	84	20	25	32	12	5	13	0	0.94	0.98
595	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4)	2683253	36	19	35	16	14	12	2	3	5	0	0.95	0.98
596	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4)	2683253	36	19	35	16	14	12	2	3	5	0	0.95	0.98
597	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CDK5(1), CDK5R1(5), CFL1(1), CHN1(1), LIMK1(7), MYL2(1), MYLK(17), NCF2(6), PAK1(3), PDGFRA(29), PLD1(16), PPP1R12B(18), RALBP1(7), RPS6KB1(3), TRIO(38), VAV1(16), WASF1(3)	10055447	174	43	166	48	46	68	16	6	32	6	0.95	0.98
598	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(5), B3GALT5(6), FUT1(5), FUT2(3), FUT9(12), GBGT1(6), GLA(3), HEXA(3), HEXB(4), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST8SIA1(4)	3554408	60	25	57	19	16	28	7	3	6	0	0.95	0.98
599	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), SDS(3)	4060849	58	25	57	27	20	21	5	7	5	0	0.95	0.98
600	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(7), EGF(24), EGFR(20), GRB2(3), MET(10), PDGFRA(29), PRKCA(10), SH3GLB1(8), SH3GLB2(3), SH3KBP1(10), SRC(2)	6861212	136	35	131	48	40	51	23	6	14	2	0.96	0.98
601	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	4	CDK2(5), CUL1(12)	1359910	17	12	17	2	3	10	4	0	0	0	0.96	0.98
602	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(6), PAPSS2(6), SULT1A2(2), SULT1E1(13), SULT2A1(7), SUOX(4)	2179680	39	19	36	14	10	19	6	2	2	0	0.96	0.99
603	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(13), CD2(4), CD33(11), CD5(7), IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL5(2), ITGAX(9), TLR2(12), TLR4(14), TLR7(15), TLR9(7)	6604765	117	35	114	44	34	47	15	8	11	2	0.97	0.99
604	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(4), COQ5(4), COQ6(3), COQ7(3), NDUFA13(1)	1409144	16	13	16	5	2	9	3	1	1	0	0.97	0.99
605	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ESCO1(11), ESCO2(6), NAT6(2), PNPLA3(6), SH3GLB1(8)	5790253	55	26	55	21	17	24	6	0	8	0	0.98	0.99
606	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(9), HADHA(7), SDS(3)	1618986	23	13	23	14	6	10	3	4	0	0	0.98	1.00
607	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), ABP1(12), AOC2(6), AOC3(14), CES1(12), DDHD1(14), ESCO1(11), ESCO2(6), LIPA(6), NAT6(2), PLA1A(5), PNPLA3(6), PPME1(1), PRDX6(2), SH3GLB1(8)	8989268	110	34	107	41	31	38	21	5	13	2	0.98	1.00
608	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), ASCC3(25), ATP13A2(6), DDX18(14), DDX19A(1), DDX23(12), DDX4(18), DDX41(2), DDX47(8), DDX50(11), DDX52(7), DDX54(8), DDX55(5), DDX56(6), DHFR(3), DHX58(5), ENTPD7(7), ERCC2(4), ERCC3(11), FPGS(3), GCH1(2), GGH(3), IFIH1(5), NUDT5(1), NUDT8(1), PTS(2), QDPR(1), RAD54B(14), RAD54L(5), RUVBL2(6), SETX(41), SKIV2L2(20), SMARCA2(24), SMARCA5(19), SPR(2)	21254270	317	59	305	94	78	120	58	17	37	7	0.98	1.00
609	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4)	4558447	68	24	66	17	21	25	11	3	8	0	0.99	1.00
610	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMC2(2), PSMC3(1), PSMD1(14), PSMD11(5), PSMD12(4), PSMD13(1), PSMD2(11), PSMD6(2)	5593078	79	28	74	21	18	33	12	2	14	0	0.99	1.00
611	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(1), ECHS1(3), EHHADH(9), HADH(1), HADHA(7), HSD17B10(4), HSD17B4(10), NTAN1(3), SIRT1(8), SIRT2(7), SIRT5(3), VNN2(10)	3895700	66	22	64	21	15	36	9	4	2	0	0.99	1.00
612	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(5), FUT2(3), FUT9(12), GBGT1(6), GLA(3), HEXA(3), HEXB(4), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), ST8SIA1(4)	3332855	53	22	52	16	14	24	9	3	3	0	0.99	1.00
613	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), CDIPT(1), CDS1(3), CDS2(2), CHAT(1), CHKA(8), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), ESCO1(11), ESCO2(6), ETNK1(9), ETNK2(3), GNPAT(11), GPAM(7), GPD1(6), GPD1L(3), GPD2(5), LCAT(2), LYPLA1(2), LYPLA2(5), NAT6(2), PCYT1A(7), PCYT1B(4), PEMT(2), PISD(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(4), PPAP2B(3), PTDSS1(6), PTDSS2(1), SH3GLB1(8)	21566165	330	60	327	117	87	131	48	20	42	2	1.00	1.00
614	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), UGDH(3)	2749695	26	16	25	12	11	8	2	2	3	0	1.00	1.00
615	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(6), SRP19(3), SRP54(6), SRP68(6), SRP72(8), SRP9(3), SRPR(8)	2641667	42	18	41	12	11	17	5	3	6	0	1.00	1.00
616	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(7), ACAD9(10), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ESCO1(11), ESCO2(6), NAT6(2), PNPLA3(6), SH3GLB1(8)	8769627	117	32	116	32	30	47	18	2	18	2	1.00	1.00