E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.173 -9999.0 0.0 -0.452 74.0 74.0 KLHL20 -0.015 0.099 -9999.0 0.0 -0.247 26.0 26.0 CYFIP2 -0.042 0.164 -9999.0 0.0 -0.468 65.0 65.0 Rac1/GDP 0.006 0.113 -9999.0 0.0 -0.254 74.0 74.0 ENAH -0.036 0.175 -9999.0 0.0 -0.448 76.0 76.0 AP1M1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 RAP1B 0.013 0.044 -9999.0 0.0 -0.321 8.0 8.0 RAP1A 0.012 0.057 -9999.0 0.0 -0.521 6.0 6.0 CTNNB1 0.001 0.09 -9999.0 0.0 -0.451 19.0 19.0 CDC42/GTP -0.032 0.069 -9999.0 0.0 -0.299 10.0 10.0 ABI1/Sra1/Nap1 -0.042 0.054 -9999.0 0.0 -0.172 37.0 37.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.005 0.115 -9999.0 0.0 -0.275 79.0 79.0 RAPGEF1 -0.015 0.151 -9999.0 0.0 -0.377 74.0 74.0 CTNND1 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.174 -9999.0 0.0 -0.461 74.0 74.0 CRK -0.024 0.162 -9999.0 0.0 -0.412 75.0 75.0 E-cadherin/gamma catenin/alpha catenin -0.01 0.115 -9999.0 0.0 -0.309 65.0 65.0 alphaE/beta7 Integrin 0.023 0.038 -9999.0 0.0 -0.369 5.0 5.0 IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.031 -9999.0 0.0 -0.321 4.0 4.0 Rap1/GTP/I-afadin 0.014 0.073 -9999.0 0.0 -0.281 28.0 28.0 DLG1 -0.031 0.169 -9999.0 0.0 -0.442 74.0 74.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.028 0.055 -9999.0 0.0 -0.216 15.0 15.0 MLLT4 -0.006 0.106 -9999.0 0.0 -0.46 26.0 26.0 ARF6/GTP/NME1/Tiam1 0.023 0.052 -9999.0 0.0 -0.304 10.0 10.0 PI3K -0.036 0.07 -9999.0 0.0 -0.28 15.0 15.0 ARF6 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.027 0.133 -9999.0 0.0 -0.374 64.0 64.0 TIAM1 0.006 0.073 -9999.0 0.0 -0.439 13.0 13.0 E-cadherin(dimer)/Ca2+ -0.005 0.106 -9999.0 0.0 -0.259 76.0 76.0 AKT1 -0.022 0.043 -9999.0 0.0 -0.172 15.0 15.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 CDH1 -0.049 0.173 -9999.0 0.0 -0.483 70.0 70.0 RhoA/GDP 0.003 0.121 -9999.0 0.0 -0.264 78.0 78.0 actin cytoskeleton organization -0.009 0.075 -9999.0 0.0 -0.178 26.0 26.0 CDC42/GDP 0.008 0.113 -9999.0 0.0 -0.253 74.0 74.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.007 0.09 -9999.0 0.0 -0.24 66.0 66.0 ITGB7 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.005 0.114 -9999.0 0.0 -0.275 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.014 0.105 -9999.0 0.0 -0.266 75.0 75.0 mol:GDP -0.004 0.127 -9999.0 0.0 -0.298 75.0 75.0 CDC42/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.056 -9999.0 0.0 -0.421 8.0 8.0 p120 catenin/RhoA/GDP 0.002 0.122 -9999.0 0.0 -0.321 26.0 26.0 RAC1/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.023 0.035 -9999.0 0.0 -0.369 4.0 4.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.027 0.094 -9999.0 0.0 -0.204 97.0 97.0 NME1 0.012 0.039 -9999.0 0.0 -0.254 11.0 11.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.172 -9999.0 0.0 -0.443 75.0 75.0 regulation of cell-cell adhesion -0.029 0.061 -9999.0 0.0 -0.261 10.0 10.0 WASF2 -0.021 0.031 -9999.0 0.0 -0.133 4.0 4.0 Rap1/GTP -0.038 0.08 -9999.0 0.0 -0.344 10.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.009 0.104 -9999.0 0.0 -0.249 70.0 70.0 CCND1 -0.035 0.116 -9999.0 0.0 -0.255 97.0 97.0 VAV2 -0.022 0.159 -9999.0 0.0 -0.404 74.0 74.0 RAP1/GDP 0.005 0.106 -9999.0 0.0 -0.357 9.0 9.0 adherens junction assembly -0.031 0.167 -9999.0 0.0 -0.429 75.0 75.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.02 -9999.0 0.0 -0.254 3.0 3.0 PIP5K1C 0.014 0.042 -9999.0 0.0 -0.454 4.0 4.0 regulation of heterotypic cell-cell adhesion 0.006 0.108 -9999.0 0.0 -0.37 5.0 5.0 E-cadherin/beta catenin -0.045 0.113 -9999.0 0.0 -0.338 66.0 66.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.033 0.17 -9999.0 0.0 -0.44 75.0 75.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 Rac1/GTP -0.078 0.122 -9999.0 0.0 -0.394 31.0 31.0 E-cadherin/beta catenin/alpha catenin -0.017 0.122 -9999.0 0.0 -0.312 75.0 75.0 ITGAE 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.178 -9999.0 0.0 -0.471 74.0 74.0