E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.17 -9999.0 0.0 -0.422 71.0 71.0 KLHL20 -0.018 0.103 0.229 7.0 -0.265 22.0 29.0 CYFIP2 -0.008 0.132 -9999.0 0.0 -0.429 45.0 45.0 Rac1/GDP -0.029 0.124 0.27 6.0 -0.301 21.0 27.0 ENAH -0.065 0.166 -9999.0 0.0 -0.428 61.0 61.0 AP1M1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 RAP1B 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 RAP1A 0.03 0.046 -9999.0 0.0 -0.429 5.0 5.0 CTNNB1 0.022 0.071 -9999.0 0.0 -0.429 12.0 12.0 CDC42/GTP -0.011 0.087 -9999.0 0.0 -0.257 8.0 8.0 ABI1/Sra1/Nap1 -0.046 0.057 -9999.0 0.0 -0.17 39.0 39.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.029 0.108 -9999.0 0.0 -0.238 63.0 63.0 RAPGEF1 -0.065 0.16 -9999.0 0.0 -0.379 72.0 72.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.071 0.186 -9999.0 0.0 -0.426 82.0 82.0 CRK -0.064 0.167 -9999.0 0.0 -0.398 80.0 80.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.101 -9999.0 0.0 -0.265 49.0 49.0 alphaE/beta7 Integrin 0.045 0.035 -9999.0 0.0 -0.307 4.0 4.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.057 -9999.0 0.0 -0.233 15.0 15.0 DLG1 -0.075 0.176 -9999.0 0.0 -0.419 79.0 79.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.057 -9999.0 0.0 -0.182 15.0 15.0 MLLT4 0.024 0.059 -9999.0 0.0 -0.429 8.0 8.0 ARF6/GTP/NME1/Tiam1 0.052 0.048 -9999.0 0.0 -0.24 10.0 10.0 PI3K -0.034 0.074 -9999.0 0.0 -0.236 14.0 14.0 ARF6 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.006 0.107 -9999.0 0.0 -0.312 49.0 49.0 TIAM1 0.027 0.058 -9999.0 0.0 -0.429 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.028 0.099 -9999.0 0.0 -0.223 60.0 60.0 AKT1 -0.02 0.055 0.156 5.0 -0.171 5.0 10.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 CDH1 -0.014 0.134 -9999.0 0.0 -0.429 47.0 47.0 RhoA/GDP -0.031 0.127 0.27 6.0 -0.317 22.0 28.0 actin cytoskeleton organization -0.011 0.08 0.172 15.0 -0.192 21.0 36.0 CDC42/GDP -0.028 0.124 0.27 6.0 -0.269 59.0 65.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.007 0.078 -9999.0 0.0 -0.223 52.0 52.0 ITGB7 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.106 -9999.0 0.0 -0.238 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.09 -9999.0 0.0 -0.22 59.0 59.0 mol:GDP -0.048 0.13 0.271 6.0 -0.307 63.0 69.0 CDC42/GTP/IQGAP1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 p120 catenin/RhoA/GDP -0.025 0.133 0.277 6.0 -0.328 21.0 27.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.034 -9999.0 0.0 -0.307 4.0 4.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 CDC42 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.029 0.081 0.137 3.0 -0.19 80.0 83.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.077 0.178 -9999.0 0.0 -0.421 80.0 80.0 regulation of cell-cell adhesion -0.018 0.071 -9999.0 0.0 -0.226 8.0 8.0 WASF2 -0.012 0.046 0.104 8.0 -0.114 11.0 19.0 Rap1/GTP -0.013 0.096 0.245 1.0 -0.287 8.0 9.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.106 -9999.0 0.0 -0.231 53.0 53.0 CCND1 -0.036 0.099 0.157 3.0 -0.236 80.0 83.0 VAV2 -0.062 0.196 -9999.0 0.0 -0.613 16.0 16.0 RAP1/GDP -0.016 0.108 0.259 2.0 -0.295 12.0 14.0 adherens junction assembly -0.073 0.173 -9999.0 0.0 -0.408 80.0 80.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.023 0.103 -9999.0 0.0 -0.222 65.0 65.0 E-cadherin/beta catenin -0.026 0.104 -9999.0 0.0 -0.293 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.077 0.177 -9999.0 0.0 -0.419 81.0 81.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 Rac1/GTP -0.078 0.135 -9999.0 0.0 -0.415 32.0 32.0 E-cadherin/beta catenin/alpha catenin 0.017 0.106 -9999.0 0.0 -0.26 59.0 59.0 ITGAE 0.028 0.042 -9999.0 0.0 -0.429 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.073 0.19 -9999.0 0.0 -0.435 82.0 82.0