Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.015 0.116 -9999.0 0.0 -0.485 8.0 8.0 IHH 0.025 0.095 -9999.0 0.0 -0.528 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.071 0.139 -9999.0 0.0 -0.303 45.0 45.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.138 0.301 45.0 -9999.0 0.0 45.0 SMO/beta Arrestin2 0.003 0.123 -9999.0 0.0 -0.373 12.0 12.0 SMO -0.007 0.117 -9999.0 0.0 -0.338 20.0 20.0 AKT1 -0.013 0.151 -9999.0 0.0 -0.402 21.0 21.0 ARRB2 0.027 0.038 -9999.0 0.0 -0.483 1.0 1.0 BOC 0.026 0.054 -9999.0 0.0 -0.244 7.0 7.0 ADRBK1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.008 0.119 -9999.0 0.0 -0.335 21.0 21.0 STIL -0.003 0.102 0.198 2.0 -0.243 26.0 28.0 DHH N/PTCH2 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.028 0.076 -9999.0 0.0 -0.296 9.0 9.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.004 0.167 -9999.0 0.0 -0.864 6.0 6.0 determination of left/right symmetry -0.008 0.119 -9999.0 0.0 -0.335 21.0 21.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 skeletal system development 0.004 0.165 -9999.0 0.0 -0.852 6.0 6.0 IHH N/Hhip -0.017 0.161 -9999.0 0.0 -0.402 28.0 28.0 DHH N/Hhip -0.008 0.134 -9999.0 0.0 -0.349 25.0 25.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.008 0.119 -9999.0 0.0 -0.335 21.0 21.0 pancreas development -0.039 0.172 -9999.0 0.0 -0.403 35.0 35.0 HHAT -0.001 0.125 -9999.0 0.0 -0.401 17.0 17.0 PI3K 0.045 0.049 -9999.0 0.0 -0.349 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.118 0.201 -9999.0 0.0 -0.329 87.0 87.0 somite specification -0.008 0.119 -9999.0 0.0 -0.335 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.004 0.091 -9999.0 0.0 -0.249 22.0 22.0 SHH Np/Cholesterol/PTCH2 0.01 0.079 -9999.0 0.0 -0.275 13.0 13.0 SHH Np/Cholesterol/Megalin 0.009 0.08 -9999.0 0.0 -0.276 13.0 13.0 SHH -0.01 0.094 -9999.0 0.0 -0.357 13.0 13.0 catabolic process 0.008 0.079 -9999.0 0.0 -0.332 9.0 9.0 SMO/Vitamin D3 -0.012 0.112 0.204 3.0 -0.333 13.0 16.0 SHH Np/Cholesterol/Hhip -0.032 0.131 -9999.0 0.0 -0.308 33.0 33.0 LRP2 0.033 0.024 -9999.0 0.0 -0.204 2.0 2.0 receptor-mediated endocytosis -0.011 0.108 -9999.0 0.0 -0.321 13.0 13.0 SHH Np/Cholesterol/BOC 0.005 0.081 -9999.0 0.0 -0.276 13.0 13.0 SHH Np/Cholesterol/CDO 0.008 0.079 -9999.0 0.0 -0.276 13.0 13.0 mesenchymal cell differentiation 0.032 0.13 0.307 33.0 -9999.0 0.0 33.0 mol:Vitamin D3 0.005 0.101 0.201 9.0 -0.249 22.0 31.0 IHH N/PTCH2 0.044 0.063 -9999.0 0.0 -0.318 5.0 5.0 CDON 0.033 0.024 -9999.0 0.0 -0.204 2.0 2.0 IHH N/PTCH1 0.027 0.084 -9999.0 0.0 -0.304 11.0 11.0 Megalin/LRPAP1 0.049 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.074 -9999.0 0.0 -0.274 13.0 13.0 PTCH1 0.008 0.079 -9999.0 0.0 -0.333 9.0 9.0 HHIP -0.039 0.172 -9999.0 0.0 -0.403 35.0 35.0