rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(1), AKT2(1), AKT3(1), BRD4(7), CBL(1), CDKN2A(3), FLOT1(2), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), LNPEP(2), MAPK1(3), MAPK3(2), PARD3(2), PARD6A(1), PIK3CA(19), PIK3CD(2), PIK3R1(17), PPYR1(2), PTEN(80), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SERPINB6(1), SLC2A4(3), SORBS1(2), SOS1(1), SOS2(4), YWHAB(1), YWHAE(2)	23158627	182	128	162	32	30	35	21	36	60	0	<1.00e-15	<1.28e-13
2	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(1), CDKN2A(3), MDM2(1), PIK3CA(19), PIK3R1(17), POLR1A(3), POLR1B(1), POLR1C(1), RB1(21), TBX2(1), TP53(91)	8040458	159	113	126	13	28	28	20	25	54	4	<1.00e-15	<1.28e-13
3	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(1), AKT2(1), AKT3(1), BTK(1), CDKN2A(3), GSK3B(1), IARS(4), IGFBP1(1), INPP5D(6), PIK3CA(19), PTEN(80), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SOS1(1), SOS2(4), TEC(5), YWHAB(1), YWHAE(2)	14274206	141	109	124	17	23	35	15	23	45	0	<1.00e-15	<1.28e-13
4	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(1), ATM(7), CDKN1A(1), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MDM2(1), NFKBIB(1), TP53(91)	8064819	110	83	84	5	29	22	13	16	26	4	2.44e-15	1.28e-13
5	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BCL2(3), BID(4), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), GZMB(3), MAP3K1(5), MAP3K14(2), MDM2(1), NFKB1(1), NFKBIA(2), PARP1(3), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(5), TP53(91), TRAF1(1), TRAF2(2)	15017861	136	96	107	18	31	20	25	25	31	4	2.78e-15	1.28e-13
6	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(58), ERBB3(4), NRG1(4)	4194729	69	59	37	7	13	21	26	8	1	0	4.11e-15	1.28e-13
7	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(8), DAXX(4), PAX3(3), PML(2), RARA(5), RB1(21), SIRT1(2), SP100(3), TNFRSF1A(2), TNFRSF1B(2), TP53(91)	7623942	143	102	112	11	31	21	20	21	46	4	4.55e-15	1.28e-13
8	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(7), ATR(9), BRCA1(4), CDC25B(1), CDKN1A(1), CDKN2D(1), CHEK1(5), EP300(6), MDM2(1), MYT1(7), PRKDC(5), TP53(91)	16932144	138	96	112	10	34	23	22	21	32	6	4.88e-15	1.28e-13
9	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(1), AKT3(1), BPNT1(1), ILK(2), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3CD(2), PTEN(80), PTK2B(1), RBL2(1), SOS1(1)	8079012	115	104	98	7	14	26	13	24	38	0	5.55e-15	1.28e-13
10	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1C(2), AKT1(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BDNF(1), BRAF(6), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(4), CACNG6(1), CACNG7(1), CACNG8(1), CD14(2), CDC25B(1), CHUK(4), DAXX(4), DDIT3(1), DUSP10(1), DUSP14(1), DUSP16(1), DUSP2(2), DUSP4(3), DUSP8(1), DUSP9(1), EGF(3), EGFR(58), ELK1(1), ELK4(1), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(14), FLNB(4), FLNC(6), FOS(1), GADD45B(1), GNA12(2), IKBKB(2), IL1R1(2), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(1), MKNK1(1), NF1(34), NFATC2(1), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(3), NRAS(1), NTF3(1), NTRK1(4), NTRK2(1), PAK1(2), PDGFRA(10), PDGFRB(5), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PPM1B(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTPRR(2), RAP1B(2), RAPGEF2(4), RASA2(1), RASGRF1(5), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA2(2), RPS6KA3(5), RRAS2(3), SOS1(1), SOS2(4), SRF(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(2), TAOK3(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF1A(2), TP53(91), TRAF2(2), ZAK(1)	111569559	592	212	520	148	184	87	111	98	100	12	5.66e-15	1.28e-13
11	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNG(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(4), NFKB1(1), NFKBIA(2), RB1(21), TNFRSF1A(2), TNFRSF1B(2), TP53(91), USH1C(1), WT1(3)	7240609	132	96	103	10	31	17	17	18	45	4	5.77e-15	1.28e-13
12	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NFKB1(1), PIK3CA(19), PIK3R1(17), RB1(21), SP1(6)	7874439	79	65	72	7	8	14	7	16	34	0	5.77e-15	1.28e-13
13	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), ITK(3), PIK3CA(19), PIK3R1(17), PTPN11(6)	5210686	52	45	47	7	5	11	8	17	11	0	5.77e-15	1.28e-13
14	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(1), ACTN1(1), ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGEF7(1), BRAF(6), CAV1(1), CDKN2A(3), CSE1L(2), DOCK1(9), EPHB2(6), GRB7(1), GRLF1(4), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CA(19), PIK3CB(2), PKLR(4), PLCG1(3), PLCG2(11), PTEN(80), PTK2(2), RALA(1), RHO(1), ROCK1(3), ROCK2(4), SOS1(1), SOS2(4), SRC(2), TERF2IP(3), TLN1(6), TLN2(5), VASP(2), ZYX(2)	48062722	265	143	245	58	68	49	41	50	57	0	5.88e-15	1.28e-13
15	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(4), AKT1(1), AKT2(1), AKT3(1), APAF1(1), ATM(7), BCL2(3), BID(4), BIRC2(1), BIRC3(1), CAPN1(5), CAPN2(1), CASP6(1), CHUK(4), CSF2RB(4), DFFA(1), DFFB(3), IKBKB(2), IL1R1(2), IL1RAP(2), IRAK1(2), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RIPK1(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(5), TP53(91), TRAF2(2)	32877178	236	133	201	39	59	40	36	53	44	4	5.88e-15	1.28e-13
16	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(19), PIK3R1(17), PLCB1(4), PLCG1(3), PRKCA(3), VAV1(6)	5190925	53	43	48	8	8	12	8	13	10	2	6.33e-15	1.28e-13
17	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(1), ATM(7), ATR(9), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), DHFR(1), GSK3B(1), HDAC1(1), RB1(21), TGFB1(1), TGFB2(1), TP53(91)	12112046	144	96	116	11	30	24	19	17	50	4	6.44e-15	1.28e-13
18	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(7), BCL2(3), CCNE1(1), CDKN1A(1), MDM2(1), PCNA(1), RB1(21), TIMP3(2), TP53(91)	7375110	129	93	101	4	27	21	17	16	44	4	6.44e-15	1.28e-13
19	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(3), EGFR(58), MAP2K1(1), MAPK1(3), MAPK3(2), PTPRB(4), SOS1(1), SPRY1(1), SPRY2(2), SRC(2)	9691451	78	66	45	14	14	23	26	12	3	0	6.55e-15	1.28e-13
20	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(3), EGFR(58), HGS(3), TFRC(2)	5146012	68	59	36	9	9	23	25	8	3	0	6.55e-15	1.28e-13
21	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PAK1(2), PIK3CA(19), PIK3R1(17), RB1(21)	8106529	73	62	66	7	5	13	9	15	31	0	6.77e-15	1.28e-13
22	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), CDKN1B(3), ILK(2), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3R1(17), PTEN(80), PTK2(2), SOS1(1)	7670831	130	116	110	4	12	30	15	26	47	0	6.88e-15	1.28e-13
23	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(4), EIF4B(3), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), FKBP1A(1), MKNK1(1), PIK3CA(19), PIK3R1(17), PPP2CA(1), PTEN(80), RPS6KB1(1), TSC1(4), TSC2(2)	10941579	141	117	121	5	15	30	17	25	54	0	6.99e-15	1.28e-13
24	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(4), DNAJC3(3), EIF2S2(1), MAP3K14(2), NFKB1(1), NFKBIA(2), TP53(91)	3932195	104	84	77	5	24	16	15	18	27	4	7.33e-15	1.28e-13
25	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(3), EGF(3), EGFR(58), MET(5), PDGFRA(10), PRKCA(3), SH3GLB1(2), SH3GLB2(4), SH3KBP1(3), SRC(2)	7910833	94	68	62	12	17	27	33	12	5	0	7.33e-15	1.28e-13
26	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), BCL2(3), EGFR(58), IGF1R(2), POLR2A(2), PPP2CA(1), PRKCA(3), RB1(21), TEP1(4), TERT(8), TNKS(4), TP53(91), XRCC5(1)	11328048	199	139	137	11	45	40	42	22	46	4	7.66e-15	1.28e-13
27	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	191	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ARHGAP5(2), BCL2(3), BIRC2(1), BIRC3(1), BRAF(6), CAPN2(1), CAV1(1), CAV3(1), CCND2(1), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A3(27), COL6A6(7), COMP(1), DIAPH1(2), DOCK1(9), EGF(3), EGFR(58), ELK1(1), ERBB2(7), FARP2(2), FIGF(1), FLNA(14), FLNB(4), FLNC(6), FLT1(2), FN1(3), GRLF1(4), GSK3B(1), HGF(4), IGF1R(2), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KDR(10), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), MAP2K1(1), MAPK1(3), MAPK3(2), MAPK9(2), MET(5), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARVB(1), PARVG(2), PDGFC(3), PDGFD(2), PDGFRA(10), PDGFRB(5), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(1), PTEN(80), PTK2(2), PXN(1), RAP1B(2), RELN(20), RHOA(1), ROCK1(3), ROCK2(4), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TLN1(6), TLN2(5), TNC(7), TNN(5), TNR(2), TNXB(6), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), VEGFA(2), VEGFC(2), VWF(10), ZYX(2)	145099378	743	225	677	196	216	144	141	115	125	2	7.99e-15	1.28e-13
28	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(7), CDC25B(1), CHEK1(5), MYT1(7), RB1(21), TP53(91)	7149998	132	95	104	3	30	19	15	17	47	4	7.99e-15	1.28e-13
29	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(58), MAP2K1(1), MAP3K1(5), MAPK14(1), NCOR2(5), RARA(5), RXRA(3), THRA(1)	6703510	82	65	47	13	14	24	25	14	5	0	8.22e-15	1.28e-13
30	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(7), ATR(9), CHEK1(5), TP53(91)	6573020	112	89	86	4	28	19	14	19	28	4	8.55e-15	1.28e-13
31	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(3), AGTR2(1), EDNRA(1), EDNRB(1), EGF(3), EGFR(58), FOS(1), NFKB1(1), PLCG1(3), PRKCA(3)	8308721	76	63	44	18	12	24	26	12	2	0	8.55e-15	1.28e-13
32	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(1), AKT3(1), CDKN1B(3), CDKN2A(3), CREB3(1), CREB5(1), ERBB4(1), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), MET(5), NOLC1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARD3(2), PARD6A(1), PIK3CA(19), PIK3CD(2), PREX1(9), PTEN(80), PTK2(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SLC2A4(3), SOS1(1), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAE(2)	30024023	181	123	164	27	35	33	23	34	56	0	8.77e-15	1.28e-13
33	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(1), ATM(7), BCL2(3), BID(4), CASP6(1), PRKCA(3), PTK2(2), PXN(1), STAT1(1), TLN1(6), TP53(91)	11107554	121	89	92	5	31	19	17	23	27	4	8.77e-15	1.28e-13
34	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(3), BTK(1), CFL2(1), INPPL1(4), ITPR1(7), ITPR2(11), ITPR3(11), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CA(19), PIK3CD(2), PIK3CG(12), PIK3R1(17), PTEN(80), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), WASF1(1)	27707675	205	139	185	32	44	40	31	32	58	0	9.10e-15	1.28e-13
35	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(2), ATF2(1), CALM1(1), EGFR(58), ELK1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP3K1(5), MAPK1(3), MAPK3(2), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(2), PRKCA(3), PTK2(2), PTK2B(1), SOS1(1), SRC(2), SYT1(1)	13533119	94	69	62	19	17	27	32	15	3	0	9.21e-15	1.28e-13
36	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(7), CCNA1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2C(4), CDKN2D(1), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F2(3), E2F3(2), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MYT1(7), NACA(7), PCNA(1), POLA2(3), POLE(4), POLE2(2), PRIM1(1), RB1(21), RBL1(3), TFDP2(1), TNXB(6), TP53(91)	29776866	198	110	167	30	50	29	32	22	61	4	9.33e-15	1.28e-13
37	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(7), ATR(9), BRCA1(4), BRCA2(7), CHEK1(5), FANCA(4), FANCC(2), FANCD2(4), FANCG(1), MRE11A(3), RAD1(1), RAD17(3), RAD50(2), RAD9A(1), TP53(91)	17966317	144	96	118	9	35	23	18	28	34	6	9.33e-15	1.28e-13
38	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(6), CASP8AP2(3), CD7(2), DAXX(4), DEDD2(2), DFFA(1), DIABLO(1), EGFR(58), EPHB2(6), FAF1(3), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MET(5), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), NR0B2(3), PTPN13(4), RALBP1(3), RIPK1(1), ROCK1(3), TNFRSF6B(2), TP53(91), TPX2(1), TRAF2(2), TUFM(1)	28393004	243	142	184	36	57	53	55	36	38	4	9.44e-15	1.28e-13
39	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), EGF(3), EGFR(58), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2)	15160099	127	96	90	18	22	36	32	23	14	0	9.44e-15	1.28e-13
40	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(6), EGFR(58), ERBB2(7), ERBB4(1), ETV7(1), FMN2(2), KRAS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(3), PIWIL3(4), PIWIL4(1), SOS1(1), SOS2(4), SPIRE1(3), SPIRE2(4)	20472230	124	88	84	26	24	27	33	25	15	0	9.44e-15	1.28e-13
41	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), MINPP1(1), MIOX(1), OCRL(1), PI4KA(1), PI4KB(3), PIK3C3(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PTEN(80), SYNJ1(1), SYNJ2(7)	29194980	206	131	188	33	50	41	29	31	53	2	9.55e-15	1.28e-13
42	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(1), DLD(1), DUSP10(1), DUSP4(3), DUSP8(1), GAB1(1), GCK(2), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK7(3), MAPK9(2), NFATC3(1), PAPPA(6), TP53(91), ZAK(1)	20108047	146	101	118	22	46	21	19	24	32	4	9.66e-15	1.28e-13
43	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(5), CAPN2(1), CAPNS1(1), CXCR3(2), EGF(3), EGFR(58), ITGA1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(6)	12938269	98	72	66	16	22	24	32	17	3	0	9.66e-15	1.28e-13
44	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), ATM(7), ATR(9), BAI1(1), BID(4), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(3), CHEK1(5), DDB2(1), GADD45B(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(2), PERP(3), PPM1D(1), PTEN(80), RFWD2(2), RPRM(1), SERPINB5(2), SERPINE1(1), SESN1(2), SESN2(1), SESN3(4), STEAP3(2), THBS1(3), TP53(91), TP53I3(2), TP73(1), TSC2(2)	25535861	243	158	199	28	44	51	32	39	71	6	9.77e-15	1.28e-13
45	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(58), ELK1(1), GNAS(3), GNB1(1), GNGT1(1), IGF1R(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NGFR(1), PDGFRA(10), PPP2CA(1), PTPRR(2), SOS1(1), SRC(2), STAT3(2)	13280414	93	73	61	15	21	28	31	11	2	0	9.77e-15	1.28e-13
46	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), PAK1(2), PDGFRA(10), PIK3CA(19), PIK3R1(17)	5451834	53	44	48	2	4	11	10	14	14	0	9.77e-15	1.28e-13
47	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CHUK(4), GH1(1), GHR(3), NFKB1(1), NFKBIA(2), PIK3CA(19), PIK3R1(17), PPP2CA(1)	5686812	49	43	43	5	6	10	6	15	12	0	9.77e-15	1.28e-13
48	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MAX(2), SP1(6), SP3(1), TP53(91), WT1(3)	2849491	104	86	78	2	27	17	14	14	28	4	1.01e-14	1.28e-13
49	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(9), ELK1(1), FOS(1), GAB1(1), HGF(4), ITGA1(1), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK1(3), MAPK3(2), MET(5), PAK1(2), PIK3CA(19), PIK3R1(17), PTEN(80), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), SOS1(1), SRC(2), STAT3(2)	17751751	166	127	146	11	25	35	22	35	49	0	1.02e-14	1.28e-13
50	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(1), ABL2(1), AKT1(1), AKT2(1), AKT3(1), ARAF(1), AREG(1), BRAF(6), CAMK2B(1), CAMK2D(1), CAMK2G(4), CBL(1), CBLB(1), CBLC(1), CDKN1A(1), CDKN1B(3), EGF(3), EGFR(58), ELK1(1), ERBB2(7), ERBB3(4), ERBB4(1), GAB1(1), GSK3B(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK9(2), NRAS(1), NRG1(4), NRG2(1), NRG3(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SRC(2), STAT5A(2), STAT5B(2), TGFA(2)	40950577	223	129	181	52	58	44	49	46	26	0	1.04e-14	1.28e-13
51	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(2), CDKN2A(3), FLOT1(2), GAB1(1), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), NR0B2(3), PIK3CA(19), PLCG2(11), PREX1(9), PTEN(80), PTPRC(4), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SYK(2), TEC(5), VAV1(6)	21953122	190	130	173	30	42	41	28	30	49	0	1.07e-14	1.28e-13
52	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CDS1(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(6), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), OCRL(1), PI4KA(1), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C2G(9), PIK3C3(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PRKCA(3), PRKCG(1), PTEN(80), SYNJ1(1), SYNJ2(7)	49165194	309	168	287	50	81	56	46	51	73	2	1.08e-14	1.28e-13
53	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BCL2(3), BID(4), BIRC2(1), BIRC3(1), BIRC5(1), BNIP3L(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GZMB(3), IKBKB(2), IRF2(1), IRF4(2), IRF5(5), IRF6(6), MAP3K1(5), MDM2(1), NFKB1(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PLEKHG5(2), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFSF10(5), TP53(91), TP73(1), TRAF1(1), TRAF2(2), TRAF3(3)	22658299	171	105	137	33	38	26	30	34	39	4	1.11e-14	1.29e-13
54	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN1A(1), CDKN1B(3), CDKN2A(3), E2F2(3), MDM2(1), TP53(91)	3180125	102	83	76	8	25	20	12	13	28	4	1.22e-14	1.38e-13
55	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(7), ASAH1(1), BRAF(6), CCL13(1), CCL15(1), DAG1(2), EGFR(58), GNA11(2), GNA15(4), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), MAPK14(1), PHKA2(4), PIK3CA(19), PIK3CD(2), PIK3R1(17), SRC(2)	21236766	168	99	128	26	34	42	41	34	17	0	1.23e-14	1.38e-13
56	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2S2(1), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1R(2), INPPL1(4), PIK3CA(19), PIK3R1(17), PPP2CA(1), PTEN(80), RPS6KB1(1)	7893717	132	119	112	4	13	30	14	26	49	0	1.29e-14	1.42e-13
57	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(1), KLRC1(1), KLRC3(3), MAP2K1(1), MAPK3(2), PAK1(2), PIK3CA(19), PIK3R1(17), PTK2B(1), PTPN6(4), SYK(2), VAV1(6)	7518622	61	48	56	13	10	9	16	13	13	0	1.41e-14	1.52e-13
58	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(1), ATM(7), BRCA1(4), CDKN1A(1), CHEK1(5), MDM2(1), MRE11A(3), NFKB1(1), NFKBIA(2), RAD50(2), RBBP8(2), TP53(91), TP73(1)	12007050	121	88	95	9	29	23	15	21	29	4	1.50e-14	1.59e-13
59	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), MAPK1(3), MAPK3(2), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(4), PIK3CA(19), PIK3R1(17), PLCG1(3)	7509289	55	51	50	11	8	13	8	16	10	0	1.52e-14	1.59e-13
60	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(3), IRS1(4), MAPK1(3), MAPK14(1), MAPK3(2), MKNK1(1), PIK3CA(19), PIK3R1(17), PRKCA(3), PTEN(80), RPS6KB1(1)	11296925	146	118	126	7	19	29	17	32	49	0	1.74e-14	1.79e-13
61	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CHUK(4), ELK1(1), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(1), PIK3CA(19), PIK3R1(17), RALA(1), RALBP1(3), RALGDS(3), RHOA(1)	7628802	55	48	49	6	7	9	7	17	15	0	2.33e-14	2.35e-13
62	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(1), ATM(7), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(5), CDC20(2), CDC25B(1), CDC7(2), CDH1(3), CDKN1A(1), CDKN2A(3), CHEK1(5), E2F2(3), E2F3(2), EP300(6), ESPL1(8), GSK3B(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), HDAC8(1), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MPL(2), PCNA(1), PLK1(1), PRKDC(5), PTPRA(4), PTTG2(2), RB1(21), RBL1(3), SMAD4(1), TBC1D8(4), TGFB1(1), TP53(91)	44091931	227	118	198	41	51	38	43	27	62	6	2.68e-14	2.66e-13
63	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(1), ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ATM(7), ATR(9), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDC20(2), CDC23(1), CDC25B(1), CDC27(3), CDC7(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2C(4), CDKN2D(1), CHEK1(5), CREBBP(8), CUL1(5), E2F2(3), E2F3(2), EP300(6), ESPL1(8), GADD45B(1), GSK3B(1), HDAC1(1), HDAC2(3), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(5), PTTG2(2), RB1(21), RBL1(3), RBL2(1), SMAD3(1), SMAD4(1), SMC1A(7), SMC1B(3), TGFB1(1), TGFB2(1), TP53(91), YWHAB(1), YWHAE(2)	54445600	264	129	235	42	53	45	52	32	76	6	3.38e-14	3.30e-13
64	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), NTRK1(4), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), SOS1(1)	6243278	48	44	43	8	6	11	6	15	10	0	3.44e-14	3.31e-13
65	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(3), RB1(21), SP1(6), SP3(1)	2702392	32	27	30	4	3	2	3	3	21	0	6.93e-14	6.57e-13
66	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), GH1(1), GHR(3), IGF1R(2), PIK3CA(19), PIK3R1(17), SOD3(1)	5298809	44	40	39	5	6	11	5	12	10	0	1.40e-13	1.31e-12
67	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), BRAF(6), CREB3(1), CREB5(1), CREBBP(8), DAG1(2), EGR1(2), EGR2(3), EGR3(4), ELK1(1), GNAQ(1), MAP1B(9), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NTRK1(4), OPN1LW(3), PIK3C2G(9), PIK3CA(19), PIK3CD(2), PIK3R1(17), PTPN11(6), RPS6KA3(5), SRC(2), TERF2IP(3)	19993337	129	80	121	22	27	22	26	36	18	0	2.86e-13	2.63e-12
68	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(3), CHUK(4), DAXX(4), EGF(3), EGFR(58), FOS(1), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), RIPK1(1), SP1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	19744800	125	82	92	30	25	31	39	20	10	0	4.75e-13	4.30e-12
69	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(5), MYL2(2), MYLK(7), PAK1(2), PDGFRA(10), PIK3CA(19), PIK3R1(17), PPP1R12B(6), RALBP1(3), RPS6KB1(1), TRIO(8), VAV1(6), WASF1(1)	14138892	90	62	85	17	16	16	22	20	16	0	2.79e-12	2.49e-11
70	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(2), APOA2(1), CD36(2), CREBBP(8), EHHADH(2), EP300(6), HSD17B4(1), MAPK1(3), MAPK3(2), ME1(4), MRPL11(1), NCOA1(3), NCOR1(6), NCOR2(5), NFKBIA(2), NR0B2(3), NR1H3(1), NRIP1(3), PIK3CA(19), PIK3R1(17), PPARA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RB1(21), RXRA(3), SP1(6), STAT5A(2), STAT5B(2)	24558471	132	83	125	26	22	16	24	28	38	4	4.20e-12	3.70e-11
71	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), CALM1(1), GNAS(3), GNB1(1), GNGT1(1), NFKB1(1), NOS3(5), NR3C1(1), PIK3CA(19), PIK3R1(17), SYT1(1)	7028218	52	43	47	9	8	10	7	14	13	0	6.31e-12	5.48e-11
72	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(1), CHRNG(1), MUSK(1), PIK3CA(19), PIK3R1(17), PTK2(2), PTK2B(1), SRC(2), TERT(8)	6387994	53	41	48	5	12	11	6	12	12	0	7.98e-12	6.83e-11
73	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	243	ACVR1(3), ACVR2A(5), ACVR2B(1), AMHR2(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CCL13(1), CCL15(1), CCL19(1), CCL2(2), CCL20(1), CCL22(1), CCL24(1), CCL26(1), CCL3(1), CCL5(1), CCL7(1), CCR1(2), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CD70(1), CLCF1(1), CNTF(1), CSF1R(3), CSF2RB(4), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL13(1), CXCL6(3), CXCR3(2), CXCR6(1), EDA(3), EGF(3), EGFR(58), EPO(1), EPOR(1), FLT1(2), FLT3(7), FLT3LG(1), FLT4(3), GDF5(2), GH1(1), GH2(2), GHR(3), HGF(4), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL17RA(9), IL17RB(1), IL18R1(1), IL18RAP(4), IL1R1(2), IL1RAP(2), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), INHBA(3), INHBB(2), INHBE(1), KDR(10), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(1), MET(5), MPL(2), NGFR(1), OSM(1), OSMR(2), PDGFC(3), PDGFRA(10), PDGFRB(5), PPBP(2), PRL(3), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF10A(2), TNFRSF11A(3), TNFRSF12A(2), TNFRSF13B(2), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(3), TNFSF10(5), TNFSF11(4), TNFSF13B(2), TNFSF14(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFC(2), XCL1(2), XCL2(2), XCR1(1)	69038532	355	152	315	86	104	62	92	62	35	0	8.76e-12	7.39e-11
74	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDKN1B(3), CUL1(5), RB1(21), UBE2M(3)	3464136	33	28	31	4	3	3	5	0	22	0	1.41e-11	1.16e-10
75	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(8), AKT1(1), BCL2(3), CSF2RB(4), IGF1R(2), KIT(3), KITLG(2), PIK3CA(19), PIK3R1(17), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	8335460	62	48	57	6	14	11	10	15	12	0	1.41e-11	1.16e-10
76	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(1), AKT3(1), KDR(10), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NOS3(5), NRAS(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), SH2D2A(2), SPHK1(1), SPHK2(2), SRC(2), VEGFA(2)	28188206	154	93	143	39	45	23	25	34	25	2	1.78e-11	1.44e-10
77	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), ELAVL1(1), FLT1(2), FLT4(3), HIF1A(1), KDR(10), NOS3(5), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), PTK2(2), PXN(1), VHL(1)	13402316	77	58	72	13	16	13	10	22	16	0	2.07e-11	1.65e-10
78	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PIK3CA(19), PIK3CD(2), PIK3R1(17), SYT1(1), TRAF2(2), TRAF3(3), TRAF5(1)	12589180	79	57	74	14	16	12	13	22	16	0	3.10e-11	2.44e-10
79	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3R1(17), SOS1(1)	7508202	50	43	45	4	7	11	5	16	11	0	3.44e-11	2.68e-10
80	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PDGFRA(10), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2)	13971889	76	59	71	11	13	17	13	18	15	0	4.14e-11	3.19e-10
81	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(8), AKT1(1), ASAH1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(1), MAPK1(3), MAPK3(2), PDGFRA(10), PIK3CA(19), PIK3R1(17), PLCB1(4), PRKCA(3), PTK2(2), SPHK1(1), SRC(2)	10881577	77	53	72	7	16	15	14	17	13	2	4.33e-11	3.29e-10
82	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(12), CALM1(1), CAMK1(2), HDAC5(4), IGF1R(2), INSR(5), MAPK14(1), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2), NFATC1(3), NFATC2(1), PIK3CA(19), PIK3R1(17), PPP3CB(1), SYT1(1)	13588372	78	61	73	15	14	16	13	20	15	0	5.62e-11	4.22e-10
83	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(3), ELK1(1), FOS(1), MAP2K1(1), MAPK3(2), NGFR(1), PIK3CA(19), PIK3R1(17), PLCG1(3), SOS1(1)	7669216	49	42	44	6	8	10	6	13	12	0	1.11e-10	8.24e-10
84	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CUL1(5), FBXW7(2), RB1(21)	3365196	29	26	27	5	4	2	3	0	20	0	1.14e-10	8.38e-10
85	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	GNAQ(1), GNB1(1), GNGT1(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), PIK3C2G(9), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(1), PXN(1)	10996313	65	51	60	11	10	10	10	22	13	0	1.24e-10	8.98e-10
86	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(1), AKT3(1), ASAH1(1), BRAF(6), DAG1(2), DRD2(1), EGFR(58), EPHB2(6), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), PIK3CB(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), SOS1(1), SOS2(4), SRC(2), STAT3(2), TERF2IP(3)	23295208	147	83	111	25	36	42	39	18	10	2	1.72e-10	1.23e-09
87	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(7), APC2(2), AXIN1(2), AXIN2(1), BTRC(1), CACYBP(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CCND2(1), CHD8(9), CREBBP(8), CSNK2A1(3), CTBP1(3), CTBP2(4), CUL1(5), CXXC4(2), DAAM1(1), DAAM2(1), DKK1(1), DKK2(3), DVL2(2), EP300(6), FBXW11(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NKD2(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PORCN(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RHOA(1), ROCK1(3), ROCK2(4), RUVBL1(1), SENP2(2), SFRP1(2), SFRP5(1), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(1), TBL1Y(1), TCF7(3), TCF7L2(3), TP53(91), VANGL1(2), VANGL2(1), WIF1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4)	62996458	313	137	283	71	90	41	65	53	56	8	5.61e-10	3.97e-09
88	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(1), AKT3(1), BTK(1), FCER1A(3), FCER1G(1), GAB2(3), IL4(1), INPP5D(6), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NRAS(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PRKCA(3), PRKCD(5), PRKCE(1), SOS1(1), SOS2(4), SYK(2), VAV1(6), VAV2(3), VAV3(2)	28539793	155	91	146	47	52	24	26	28	23	2	7.49e-10	5.25e-09
89	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(3), ELK1(1), FOS(1), INSR(5), IRS1(4), MAP2K1(1), MAPK3(2), PIK3CA(19), PIK3R1(17), PTPN11(6), SLC2A4(3), SOS1(1), SRF(2)	10143049	65	48	60	9	11	14	9	17	14	0	1.14e-09	7.87e-09
90	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(3), INSR(5), IRS1(4), JAK2(4), MAP2K1(1), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), PTPN6(4), SLC2A4(3), SOCS1(1), SOS1(1), SRF(2), STAT5A(2), STAT5B(2)	13171393	80	56	74	14	19	15	12	21	13	0	1.27e-09	8.72e-09
91	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(2), ACTN1(1), ACTN3(1), ACTN4(4), APC(7), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF4(2), ARHGEF7(1), ARPC1B(1), ARPC2(1), ARPC4(1), ARPC5L(1), BDKRB1(1), BDKRB2(3), BRAF(6), CD14(2), CFL2(1), CHRM2(4), CHRM3(3), CYFIP1(2), CYFIP2(1), DIAPH1(2), DIAPH2(3), DIAPH3(4), DOCK1(9), EGF(3), EGFR(58), EZR(3), F2(1), FGD1(2), FGD3(2), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FN1(3), GIT1(2), GNA12(2), GRLF1(4), GSN(2), IQGAP1(2), IQGAP2(4), IQGAP3(5), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KRAS(1), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MSN(1), MYH10(3), MYH14(6), MYH9(8), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), NCKAP1(2), NCKAP1L(4), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDGFRA(10), PDGFRB(5), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(6), PTK2(2), PXN(1), RHOA(1), ROCK1(3), ROCK2(4), RRAS2(3), SLC9A1(3), SOS1(1), SOS2(4), SSH1(1), SSH2(4), SSH3(2), TIAM1(2), TIAM2(8), TMSL3(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), WASF1(1), WASF2(1)	108426622	484	185	440	143	149	75	113	77	70	0	1.35e-09	9.15e-09
92	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ASH1L(3), CASK(2), CGN(3), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CRB3(1), CSDA(1), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41(2), EPB41L1(2), EPB41L2(2), EPB41L3(7), EXOC3(3), EXOC4(1), F11R(1), GNAI2(1), HCLS1(5), INADL(3), JAM2(1), JAM3(1), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(2), MLLT4(5), MPDZ(5), MPP5(1), MYH1(3), MYH10(3), MYH11(7), MYH13(11), MYH14(6), MYH15(3), MYH2(13), MYH3(6), MYH4(6), MYH6(5), MYH7(3), MYH7B(9), MYH8(8), MYH9(8), MYL2(2), MYLPF(1), NRAS(1), OCLN(1), PARD3(2), PARD6A(1), PARD6B(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(3), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PTEN(80), RHOA(1), RRAS2(3), SPTAN1(6), SRC(2), SYMPK(4), TJAP1(5), TJP1(2), TJP2(3), TJP3(6), ZAK(1)	76298731	336	152	317	107	117	51	55	48	65	0	1.75e-09	1.17e-08
93	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), CCL5(1), CHUK(4), CXCL1(1), EGFR(58), F11R(1), GIT1(2), IKBKB(2), JAM2(1), JAM3(1), LYN(1), MAP3K14(2), MAPK13(1), MAPK14(1), MAPK9(2), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(11), PTPN11(6), PTPRZ1(3), SRC(2), TCIRG1(2), TJP1(2)	28081300	152	89	119	44	39	35	43	24	11	0	2.44e-09	1.62e-08
94	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(3), ELK1(1), FOS(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK3(2), PIK3CA(19), PIK3R1(17), PTPN11(6), SOS1(1), SRF(2)	9870015	59	47	54	8	11	12	8	16	12	0	2.47e-09	1.62e-08
95	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(1), CUL1(5), RB1(21)	3469465	28	24	26	5	4	2	3	0	19	0	3.14e-09	2.04e-08
96	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM1(1), ELK1(1), FCER1A(3), FCER1G(1), FOS(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PIK3CA(19), PIK3R1(17), PLA2G4A(5), PLCG1(3), PPP3CB(1), SOS1(1), SYK(2), SYT1(1), VAV1(6)	17155914	83	62	78	24	12	18	12	23	16	2	3.18e-09	2.04e-08
97	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(1), AKT2(1), AKT3(1), BCL2(3), GSK3B(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), MAP4K1(1), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3CD(2), PIK3R1(17), SOCS1(1), SOS1(1), SOS2(4), STAT6(3)	14130588	77	57	71	12	17	12	13	22	13	0	3.29e-09	2.09e-08
98	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND2(1), CCNE1(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2C(4), CDKN2D(1), RB1(21), RBL1(3)	6349452	42	33	40	9	2	5	6	2	27	0	4.73e-09	2.98e-08
99	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(1), AKT3(1), BLNK(2), BTK(1), CARD11(6), CD19(2), CD22(5), CD72(2), CHUK(4), CR2(6), FOS(1), GSK3B(1), IFITM1(1), IKBKB(2), INPP5D(6), KRAS(1), LILRB3(1), LYN(1), MALT1(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(2), SYK(2), VAV1(6), VAV2(3), VAV3(2)	29303434	157	91	150	46	49	23	28	33	24	0	5.13e-09	3.19e-08
100	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(3), CREBBP(8), EP300(6), IL7(1), IL7R(1), JAK1(3), JAK3(4), PIK3CA(19), PIK3R1(17), PTK2B(1), STAT5A(2), STAT5B(2)	11281631	67	49	61	13	9	13	15	15	13	2	5.30e-09	3.26e-08
101	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCL2(3), BCR(1), FOS(1), JAK2(4), MAP2K1(1), MAP3K1(5), MAPK3(2), PIK3CA(19), PIK3R1(17), SOS1(1), STAT1(1), STAT5A(2), STAT5B(2)	11152516	60	48	54	7	11	13	9	14	13	0	6.59e-09	4.02e-08
102	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(9), GPX1(2), PRKCE(1)	3156886	30	25	28	9	6	4	10	8	2	0	7.18e-09	4.34e-08
103	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(2), AKT1(1), ANGPTL2(2), DAG1(2), GCA(1), ITGA9(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), MAP2K1(1), MAPK1(3), MAPK3(2), NR1I3(2), PAK1(2), PDE3A(1), PDE3B(4), PIK3C2G(9), PIK3CA(19), PIK3CD(2), PIK3R1(17), PLDN(1), PSME1(1), RIPK3(2), RPS4X(1), VASP(2)	19248819	109	69	104	19	24	19	19	25	22	0	8.69e-09	5.19e-08
104	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(1), APC(7), AXIN1(2), CD14(2), FZD1(1), GJA1(1), GSK3B(1), IRAK1(2), LBP(2), LEF1(1), LY96(1), NFKB1(1), PIK3CA(19), PIK3R1(17), PPP2CA(1), TLR4(1)	11708184	60	49	55	12	10	12	9	15	14	0	1.02e-08	6.04e-08
105	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(5), CACNA1D(9), CACNA1F(10), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CGA(1), EGFR(58), ELK1(1), GNA11(2), GNAQ(1), GNAS(3), GNRH1(1), GNRH2(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK9(2), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLD2(1), PRKACG(1), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(1), SOS1(1), SOS2(4), SRC(2)	50785084	267	128	229	68	90	49	62	41	21	4	1.29e-08	7.59e-08
106	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(1), BID(4), BRAF(6), CD244(1), FCER1G(1), FCGR3A(1), GZMB(3), HCST(1), HLA-A(1), HLA-B(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), ITGAL(4), ITGB2(5), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), KLRK1(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MICB(1), NCR1(2), NCR2(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), PAK1(2), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRF1(3), PRKCA(3), PRKCG(1), PTK2B(1), PTPN11(6), PTPN6(4), SH2D1B(1), SH3BP2(2), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SYK(2), TNFRSF10A(2), TNFSF10(5), ULBP1(1), VAV1(6), VAV2(3), VAV3(2), ZAP70(5)	44628599	207	112	196	79	55	27	41	49	35	0	1.40e-08	8.10e-08
107	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(8), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), GNAS(3), MAPK1(3), MAPK14(1), MAPK3(2), PIK3CA(19), PIK3R1(17), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SOS1(1)	11432502	67	50	62	13	14	12	9	21	11	0	1.41e-08	8.10e-08
108	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(1), AKT3(1), BRAF(6), CAB39(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(1), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PRKAA2(1), RICTOR(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TSC1(4), TSC2(2), ULK1(1), ULK2(6), ULK3(1), VEGFA(2), VEGFC(2)	20646165	110	69	102	24	25	21	14	26	24	0	2.18e-08	1.25e-07
109	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(8), ARHGEF1(2), F2(1), F2RL3(1), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(19), PIK3R1(17), PLCB1(4), PPP1R12B(6), PRKCA(3), PTK2B(1), ROCK1(3)	10337884	72	46	67	9	16	11	12	19	12	2	2.71e-08	1.53e-07
110	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CD3E(1), CD3G(1), ELK1(1), FOS(1), MAP2K1(1), MAP3K1(5), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PIK3CA(19), PIK3R1(17), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYT1(1), VAV1(6), ZAP70(5)	19078846	79	63	74	26	14	15	13	20	17	0	1.44e-07	8.08e-07
111	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(3), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), MPL(2), PIK3CA(19), PIK3R1(17), PLCG1(3), PRKCA(3), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), THPO(1)	12039194	64	47	58	8	15	12	10	15	12	0	1.97e-07	1.09e-06
112	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY7(3), ADCY8(4), ADCY9(5), ADORA2B(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(4), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), ATP2B4(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CCKAR(3), CCKBR(2), CD38(2), CHRM2(4), CHRM3(3), CHRNA7(2), CYSLTR1(1), CYSLTR2(1), DRD1(2), EDNRA(1), EDNRB(1), EGFR(58), ERBB2(7), ERBB3(4), ERBB4(1), GNA11(2), GNA15(4), GNAL(1), GNAQ(1), GNAS(3), GRIN1(3), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HRH1(1), HRH2(5), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), LHCGR(1), LTB4R2(2), MYLK(7), MYLK2(1), NOS1(9), NOS3(5), NTSR1(2), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), PDE1A(1), PDE1C(4), PDGFRA(10), PDGFRB(5), PHKA1(3), PHKA2(4), PHKB(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PPID(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(14), RYR2(36), RYR3(17), SLC25A5(2), SLC8A1(2), SLC8A3(2), SPHK1(1), SPHK2(2), TACR1(1), TACR3(4), TNNC1(1), TRHR(2), TRPC1(1), VDAC1(1), VDAC2(1)	105231927	542	183	501	153	223	78	113	77	49	2	2.19e-07	1.21e-06
113	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(1), AKT2(1), AKT3(1), CCL3(1), CCL5(1), CD14(2), CHUK(4), FOS(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IKBKB(2), IL12B(1), IL6(2), IRAK1(2), IRAK4(2), IRF5(5), LBP(2), LY96(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), RIPK1(1), SPP1(1), STAT1(1), TBK1(2), TLR1(2), TLR2(4), TLR4(1), TLR5(4), TLR6(6), TLR7(5), TLR8(3), TLR9(2), TRAF3(3)	35587805	151	89	141	53	32	29	22	38	30	0	2.33e-07	1.27e-06
114	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRB1(1), DRD1(2), DRD2(1), EGF(3), EGFR(58), GJA1(1), GNA11(2), GNAI2(1), GNAQ(1), GNAS(3), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(2), MAPK7(3), NPR1(6), NPR2(1), NRAS(1), PDGFC(3), PDGFD(2), PDGFRA(10), PDGFRB(5), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKG2(5), PRKX(2), SOS1(1), SOS2(4), SRC(2), TJP1(2), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	52353882	252	127	212	75	79	45	61	38	27	2	2.49e-07	1.35e-06
115	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(9), GPHN(1), NSF(1), SRC(2), UBQLN1(2)	4747449	38	29	36	8	10	5	12	8	3	0	2.92e-07	1.56e-06
116	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2(3), CBL(1), FOS(1), IL2RA(3), IL2RB(1), IRS1(4), JAK1(3), JAK3(4), MAPK1(3), MAPK3(2), PIK3CA(19), PIK3R1(17), PTPN6(4), RPS6KB1(1), SOCS1(1), SOS1(1), STAT5A(2), STAT5B(2), SYK(2)	14353386	75	53	69	13	13	12	15	21	14	0	3.78e-07	2.01e-06
117	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), MST1(10), MST1R(6)	2499702	18	17	14	5	6	0	0	4	8	0	7.04e-07	3.70e-06
118	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(3), AKT1(1), CALM1(1), CAMK1(2), CAMK4(1), CREBBP(8), ELSPBP1(1), F2(1), FGF2(1), FKBP1A(1), GATA4(2), GSK3B(1), MAP2K1(1), MAPK1(3), MAPK14(1), MAPK3(2), MEF2C(1), MYH2(13), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PIK3CA(19), PIK3R1(17), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KB1(1), SYT1(1)	19940572	94	62	89	25	17	17	16	25	19	0	1.18e-06	6.14e-06
119	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PIK3CA(19), PIK3R1(17), PTK2(2), PXN(1), ROCK1(3), SRC(2), TLN1(6)	15165527	72	50	67	10	17	12	11	16	16	0	2.00e-06	0.000010
120	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), BDKRB2(3), CALM1(1), CAV1(1), FLT1(2), FLT4(3), KDR(10), NOS3(5), PDE2A(3), PDE3A(1), PDE3B(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG2(5), RYR2(36), SLC7A1(2), SYT1(1), TNNI1(2)	15559598	84	56	83	23	38	10	10	18	8	0	2.77e-06	0.000014
121	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(1), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(2), DAG1(2), EPHB2(6), ITPKB(2), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PIK3CA(19), PIK3CD(2), PIK3R1(17), PLCG2(11), SOS1(1), SOS2(4), SYK(2), VAV1(6)	20579717	103	62	98	29	28	19	15	23	18	0	3.64e-06	0.000019
122	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(1), AKT3(1), BCL2(3), BCR(1), BLNK(2), BTK(1), CD19(2), CD22(5), CR2(6), DAG1(2), FLOT1(2), GSK3B(1), INPP5D(6), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NR0B2(3), PIK3CA(19), PIK3CD(2), PIK3R1(17), PLCG2(11), PPP3CB(1), PTPRC(4), SOS1(1), SOS2(4), SYK(2), VAV1(6)	29203279	144	82	138	33	46	22	24	27	25	0	4.04e-06	0.000020
123	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MIOX(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(9), PIK3CA(19), PIK3CB(2), PIK3CG(12), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11)	17799899	93	58	90	21	29	16	18	16	12	2	4.73e-06	0.000024
124	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN3(1), ACTN4(4), ARHGAP5(2), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(2), ESAM(1), EZR(3), F11R(1), GNAI2(1), GRLF1(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), ITK(3), JAM2(1), JAM3(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(1), MMP9(2), MSN(1), MYL2(2), MYLPF(1), NCF1(2), NCF4(1), NOX1(2), NOX3(5), OCLN(1), PECAM1(2), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), RAPGEF3(1), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(2), ROCK1(3), ROCK2(4), SIPA1(3), TXK(1), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2)	48981709	218	112	211	81	70	27	47	40	34	0	4.88e-06	0.000024
125	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	ACTB(1), CHAD(1), COL11A1(8), COL11A2(9), COL17A1(3), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A3(27), COL6A6(7), COMP(1), DES(3), DSC1(5), DSC2(2), DSC3(2), DSG1(4), DSG2(1), DSG3(8), DSG4(10), FN1(3), GJA1(1), GJA10(1), GJA8(1), GJA9(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJC2(1), GJC3(1), GJD4(3), INA(2), ITGA6(2), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(4), KRT17(3), KRT18(3), KRT19(5), KRT2(3), KRT20(1), KRT23(8), KRT24(1), KRT25(3), KRT28(3), KRT3(1), KRT31(3), KRT32(2), KRT33A(3), KRT33B(2), KRT34(3), KRT36(4), KRT37(2), KRT38(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(3), KRT72(1), KRT73(1), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(1), KRT82(1), KRT83(2), KRT84(2), KRT85(2), KRT9(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), LMNB1(1), LMNB2(3), NES(3), RELN(20), SPP1(1), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VIM(1), VWF(10)	96477536	454	166	443	181	173	84	82	56	57	2	8.92e-06	0.000044
126	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(1), AKT3(1), CARD11(6), CBL(1), CBLB(1), CBLC(1), CD28(1), CD3E(1), CD3G(1), CD4(3), CD8A(1), CD8B(1), CHUK(4), FOS(1), GRAP2(1), IFNG(1), IKBKB(2), IL2(1), IL4(1), ITK(3), KRAS(1), MALT1(3), MAP3K14(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDCD1(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PLCG1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCQ(1), PTPN6(4), PTPRC(4), RASGRP1(1), RHOA(1), SOS1(1), SOS2(4), TEC(5), VAV1(6), VAV2(3), VAV3(2), ZAP70(5)	40114332	168	95	160	58	45	25	31	41	26	0	0.000017	0.000084
127	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(1), AKT3(1), CDKN1A(1), ELK1(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(19), PIK3CD(2), SOS1(1)	6333919	34	30	32	7	9	8	3	10	4	0	0.000018	0.000087
128	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADORA1(2), ADORA2B(1), ADORA3(1), ADRA2B(6), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), C5AR1(1), CALCR(6), CALCRL(2), CCKAR(3), CCKBR(2), CGA(1), CHRM2(4), CHRM3(3), CNR1(2), CNR2(3), CRHR1(2), CTSG(4), CYSLTR1(1), CYSLTR2(1), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR1(1), GABBR2(6), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(9), GABRB1(3), GABRB2(7), GABRB3(2), GABRD(2), GABRE(6), GABRG1(2), GABRG2(6), GABRP(4), GABRQ(2), GABRR2(1), GALR1(3), GALR2(1), GH1(1), GH2(2), GHR(3), GHRHR(3), GHSR(4), GIPR(1), GLP1R(1), GLP2R(1), GLRA2(1), GLRA3(3), GLRB(1), GPR156(3), GPR50(3), GPR83(4), GRIA1(4), GRIA3(5), GRIA4(2), GRID1(3), GRID2(1), GRIK1(1), GRIK2(2), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRIN3B(1), GRM1(1), GRM2(1), GRM3(9), GRM4(5), GRM5(1), GRM6(6), GRM7(3), GRM8(8), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HRH4(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R2(2), MC2R(1), MC3R(6), MC4R(3), MC5R(2), MCHR1(2), MCHR2(3), MLNR(1), NMUR1(2), NMUR2(5), NPBWR1(2), NPFFR1(2), NPFFR2(2), NPY5R(4), NR3C1(1), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY4(2), P2RY6(2), PARD3(2), PPYR1(2), PRL(3), PRSS1(1), PTAFR(2), PTGDR(1), PTGER2(2), PTGER3(2), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(3), RXFP2(1), SCTR(2), SSTR2(1), SSTR3(2), SSTR4(4), SSTR5(2), TAAR2(1), TAAR5(1), TACR1(1), TACR3(4), THRA(1), TRHR(2), TSHB(1), TSHR(1), TSPO(1), UTS2R(1), VIPR2(2)	86690469	427	159	420	170	193	53	68	72	41	0	0.00020	0.00097
129	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	GUSB(3), RPE(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), XYLB(4)	9832004	43	32	42	16	12	6	11	10	4	0	0.00021	0.0010
130	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSS(1), GSTA1(2), GSTA4(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH1(15), IDH2(2), MGST1(1), MGST3(1)	7229533	41	29	27	6	25	2	7	6	1	0	0.00043	0.0020
131	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), ACVR1C(2), CDH1(3), CREBBP(8), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), EGFR(58), EP300(6), ERBB2(7), FARP2(2), FGFR1(3), IGF1R(2), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(3), MAPK3(2), MET(5), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(4), PTPRF(4), PTPRJ(3), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(5), RHOA(1), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(2), SSX2IP(1), TCF7(3), TCF7L2(3), TGFBR1(1), TGFBR2(5), TJP1(2), VCL(2), WASF1(1), WASF2(1)	47609853	189	104	153	43	50	43	52	26	14	4	0.00044	0.0020
132	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(1), IDH1(15), IDH2(2), MDH2(1), SUCLA2(1)	3614279	22	19	9	7	16	1	5	0	0	0	0.00044	0.0020
133	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD14(2), CD19(2), CD1B(1), CD1D(2), CD1E(1), CD22(5), CD33(3), CD34(2), CD36(2), CD38(2), CD3E(1), CD3G(1), CD4(3), CD44(4), CD5(2), CD55(2), CD7(2), CD8A(1), CD8B(1), CD9(2), CR1(5), CR2(6), CSF1R(3), CSF3R(2), DNTT(2), EPO(1), EPOR(1), FLT3(7), FLT3LG(1), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL1R1(2), IL2RA(3), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), ITGA1(1), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGAM(8), ITGB3(1), KIT(3), KITLG(2), MS4A1(2), TFRC(2), THPO(1), TPO(4)	31730473	140	79	136	52	54	23	28	23	12	0	0.00054	0.0025
134	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(4), NR0B2(3), NR1H3(1), NR1H4(3), RXRA(3)	2161711	14	14	14	3	3	2	4	3	2	0	0.00076	0.0035
135	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(1), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND2(1), CLCF1(1), CNTF(1), CREBBP(8), CSF2RB(4), CSF3R(2), EP300(6), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(3), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), IRF9(2), JAK1(3), JAK2(4), JAK3(4), LEPR(1), LIFR(1), MPL(2), OSM(1), OSMR(2), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(1), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PRL(3), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(1), SOCS4(2), SOS1(1), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(2), STAM2(2), STAT1(1), STAT2(5), STAT3(2), STAT4(1), STAT5A(2), STAT5B(2), STAT6(3), TPO(4), TYK2(3)	56568272	236	109	228	73	74	36	51	45	28	2	0.00092	0.0042
136	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(6), CALCRL(2), CRHR1(2), ELTD1(5), EMR1(4), EMR2(4), GHRHR(3), GIPR(1), GLP1R(1), GLP2R(1), GPR64(2), LPHN1(10), LPHN2(4), LPHN3(2), SCTR(2), VIPR2(2)	10559931	51	34	45	18	16	5	8	16	6	0	0.0011	0.0051
137	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), LPA(6), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1), SERPINF2(1), VWF(10)	14027949	58	43	58	22	21	10	11	5	11	0	0.0011	0.0051
138	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(1), CADM1(2), CADM3(1), CD22(5), CD226(2), CD274(1), CD276(3), CD28(1), CD34(2), CD4(3), CD58(1), CD6(2), CD8A(1), CD8B(1), CDH1(3), CDH15(3), CDH3(1), CDH4(3), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CNTN1(5), CNTN2(5), CNTNAP1(3), CNTNAP2(16), ESAM(1), F11R(1), GLG1(4), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), ICAM3(1), ICOSLG(1), ITGA4(7), ITGA6(2), ITGA8(7), ITGA9(1), ITGAL(4), ITGAM(8), ITGAV(1), ITGB2(5), ITGB7(2), ITGB8(3), JAM2(1), JAM3(1), L1CAM(7), MAG(5), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(5), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(3), NRXN3(3), OCLN(1), PDCD1(1), PECAM1(2), PTPRC(4), PTPRF(4), PTPRM(3), PVR(2), PVRL1(2), PVRL2(1), SDC1(1), SDC2(2), SDC4(1), SELE(1), SELP(2), SELPLG(2), SIGLEC1(1), VCAN(7)	58992771	229	119	226	105	91	30	39	36	31	2	0.0016	0.0070
139	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), COMT(2), DBH(6), DDC(1), FAH(1), GOT1(1), HPD(1), MAOB(1), PNMT(1), TAT(3), TPO(4), TYR(5)	12332970	66	42	64	14	35	9	9	13	0	0	0.0019	0.0084
140	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), ETNK1(1), GNPAT(4), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH2(2), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G2A(5), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB2(5), PLCG1(3), PLCG2(11), PPAP2C(1)	19737442	91	55	85	23	35	10	17	16	11	2	0.0021	0.0092
141	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C1(3), AKR1C4(2), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1B1(4), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP2S1(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHDH(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3)	21984496	98	57	97	32	38	8	24	25	3	0	0.0021	0.0093
142	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(4), BAG4(1), CASP2(1), CRADD(1), DFFA(1), DFFB(3), LMNB1(1), LMNB2(3), MADD(6), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), RB1(21), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TRAF2(2)	15466132	67	41	65	13	10	11	11	11	24	0	0.0023	0.0099
143	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSR(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH1(15), IDH2(2), MGST1(1), MGST3(1)	8541689	45	30	31	7	28	2	8	6	1	0	0.0025	0.011
144	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAS1(2), ALAS2(1), BLVRA(1), BLVRB(1), COX10(1), COX15(1), CP(4), CPOX(1), EARS2(2), EPRS(2), FECH(3), FTMT(5), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UROD(1), UROS(1)	15914536	71	43	70	22	19	6	16	21	9	0	0.0029	0.012
145	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(4), CASP6(1), DAXX(4), DFFA(1), DFFB(3), FAF1(3), LMNB1(1), LMNB2(3), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), PTPN13(4), RB1(21), RIPK2(1), SPTAN1(6)	16286291	66	40	64	12	6	11	11	13	25	0	0.0037	0.016
146	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(1), AKT3(1), IARS(4), IL13RA1(1), IL4(1), IL4R(6), INPP5D(6), JAK1(3), JAK2(4), JAK3(4), NR0B2(3), PIK3CA(19), RPS6KB1(1), SOS1(1), SOS2(4), SRC(2), STAT6(3), TYK2(3)	14689754	68	43	64	16	25	15	8	14	6	0	0.0048	0.020
147	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CANX(4), CD4(3), CD8A(1), CD8B(1), CIITA(7), CTSS(2), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), HSP90AA1(1), HSP90AB1(2), HSPA5(2), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), LGMN(1), NFYB(1), NFYC(3), PDIA3(1), PSME1(1), PSME2(1), TAP1(4), TAP2(2)	18456357	74	49	71	27	16	11	17	15	15	0	0.0050	0.021
148	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(2), CD3E(1), CD3G(1), CD4(3), CD58(1), CD8A(1), IL6(2), KITLG(2)	2527581	13	12	11	3	4	0	3	4	2	0	0.0052	0.022
149	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(1), GZMB(3), HLA-A(1), ITGAL(4), ITGB2(5), PRF1(3)	3417489	20	15	20	14	6	1	4	1	8	0	0.0054	0.022
150	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CX3CR1(2), CXCR3(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GRPR(1), LHCGR(1), MC2R(1), MC3R(6), MC4R(3), MC5R(2), NPY5R(4), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR1(1), TACR3(4), TRHR(2), TSHR(1)	19940026	98	57	98	38	43	19	18	14	4	0	0.0057	0.023
151	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(3), CD5(2), CD7(2), IFNB1(1), IFNG(1), IL12B(1), IL4(1), ITGAX(7), TLR2(4), TLR4(1), TLR7(5), TLR9(2)	7416008	33	24	33	13	13	6	9	3	2	0	0.0060	0.024
152	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	158	ADORA1(2), ADORA2B(1), ADORA3(1), ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCBP2(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CHML(2), CHRM2(4), CHRM3(3), CMKLR1(1), CNR1(2), CNR2(3), CX3CR1(2), CXCR3(2), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GPR17(1), GPR174(1), GPR27(3), GPR3(1), GPR37(3), GPR4(1), GPR50(3), GPR6(5), GPR83(4), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LHCGR(1), MC3R(6), MC4R(3), MC5R(2), MLNR(1), NMUR1(2), NMUR2(5), NPY5R(4), NTSR1(2), OPN1SW(2), OPRK1(1), OPRL1(2), OPRM1(4), OR1F1(2), OR1Q1(1), OR2H1(4), OR7A5(1), OR7C1(1), OXTR(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY6(2), PPYR1(2), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RHO(1), RRH(1), SSTR2(1), SSTR3(2), SSTR4(4), TRHR(2)	46757547	219	105	217	84	99	27	38	40	15	0	0.0065	0.026
153	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(4), HDC(3), PNMT(1), TPH1(3)	2333567	17	13	17	6	10	4	2	1	0	0	0.0070	0.028
154	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(3), CD36(2), CD44(4), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A3(27), COL6A6(7), DAG1(2), FN1(3), FNDC1(1), FNDC3A(2), GP9(1), HMMR(1), HSPG2(16), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), RELN(20), SDC1(1), SDC2(2), SDC4(1), SPP1(1), SV2B(1), SV2C(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VWF(10)	87660677	362	142	354	132	133	72	59	49	47	2	0.0071	0.029
155	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(1), CD3E(1), CD3G(1), CD4(3)	1034755	6	6	4	2	1	0	1	3	1	0	0.0077	0.031
156	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(2), ACO2(1), ACSS2(2), IDH1(15), IDH2(2), MDH2(1), SUCLA2(1)	5399865	26	21	13	7	18	1	6	1	0	0	0.0085	0.034
157	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(1), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3)	4085903	25	17	21	6	7	1	7	4	4	2	0.011	0.045
158	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), F10(1), F2(1), F5(9), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), PROC(2), SERPINC1(2), SERPING1(5)	17935830	70	45	68	18	20	17	13	10	10	0	0.013	0.051
159	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(4), BAG4(1), BCL2(3), BID(4), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), CHUK(4), CRADD(1), DAXX(4), DFFA(1), DFFB(3), GSN(2), LMNB1(1), LMNB2(3), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(1), NFKBIA(2), NUMA1(4), PRKCD(5), PRKDC(5), PSEN2(1), PTK2(2), RB1(21), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2)	27575538	101	58	95	26	16	12	23	20	30	0	0.013	0.052
160	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(2), ALOX5(1), CBR1(1), CBR3(2), CYP4F2(5), CYP4F3(5), EPX(6), GGT1(2), LPO(1), LTA4H(1), MPO(3), PLA2G2A(5), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PRDX2(2), PTGIS(1), PTGS1(2), TBXAS1(3), TPO(4)	11050498	57	36	53	18	28	5	11	5	6	2	0.014	0.053
161	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(3), ACVRL1(2), AKT1(1), BMPR1A(2), BMPR2(2), BUB1(4), CDKL1(3), CDS1(1), CLK2(2), CLK4(2), CSNK2A1(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(9), PIK3CA(19), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11), PLK3(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TGFBR1(1)	44743328	181	87	177	46	55	35	28	36	25	2	0.016	0.060
162	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA1(1), GALNS(1), GBA(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NAGLU(1), NEU1(1), NEU2(4), NEU4(4), SPAM1(6)	13554921	52	37	50	16	19	3	10	9	11	0	0.018	0.067
163	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(5), BDKRB1(1), BDKRB2(3), C1QB(1), C1QC(1), C1R(1), C1S(1), C2(2), C3(8), C3AR1(1), C5(1), C5AR1(1), C6(4), C7(6), C8A(3), C8B(5), C9(1), CD55(2), CFB(1), CFH(3), CFI(1), CPB2(1), CR1(5), CR2(6), F10(1), F13A1(5), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(2), MBL2(1), PLAU(2), PLAUR(1), PLG(2), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(5), THBD(3), VWF(10)	35749445	145	75	142	68	48	23	33	19	20	2	0.018	0.068
164	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	ADORA3(1), CCKBR(2), CCR3(2), CELSR1(10), CELSR2(9), CELSR3(8), CHRM2(4), CHRM3(3), CXCR3(2), EDNRA(1), EMR2(4), EMR3(2), FSHR(1), GHRHR(3), GPR116(9), GPR132(3), GPR133(7), GPR135(3), GPR143(1), GPR17(1), GPR18(1), GPR56(2), GPR61(2), GPR84(1), GPR88(1), GRM1(1), GRPR(1), HRH4(1), LGR6(3), LPHN2(4), LPHN3(2), LTB4R2(2), NTSR1(2), OR2M4(2), OR8G2(1), P2RY13(3), PTGFR(2), SMO(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(1)	24966910	113	60	111	45	40	15	21	23	14	0	0.018	0.068
165	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGT(3), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(5), REN(2)	3816834	27	16	27	9	11	5	5	3	3	0	0.019	0.070
166	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), EPO(1), FLT3(7), IL6(2), KITLG(2), TGFB1(1), TGFB2(1)	3311320	15	13	15	1	2	3	4	2	4	0	0.020	0.073
167	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(1), GPRC5A(1), GPRC5C(1), GPRC5D(2), GRM1(1), GRM2(1), GRM3(9), GRM4(5), GRM5(1), GRM7(3), GRM8(8)	8317755	38	28	37	29	22	2	6	4	4	0	0.022	0.080
168	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	2753369	12	12	12	5	7	2	1	1	1	0	0.022	0.081
169	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	293806	3	3	3	1	2	1	0	0	0	0	0.023	0.082
170	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1), SELP(2)	6700687	33	21	32	17	13	2	7	6	5	0	0.024	0.086
171	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ABP1(9), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), SDS(4), UPB1(1)	11727333	58	33	58	12	19	13	10	11	5	0	0.024	0.086
172	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), CHAT(3), COMT(2), DBH(6), DDC(1), GAD1(4), GAD2(3), HDC(3), PAH(1), PNMT(1), TPH1(3)	5608230	28	21	28	9	13	5	3	7	0	0	0.025	0.090
173	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(5), F2(1), FGA(3), FGB(1), FGG(4), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1)	5404654	22	20	22	8	9	5	4	2	2	0	0.026	0.093
174	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(8), ACACB(9), AKT1(1), AKT2(1), AKT3(1), ARAF(1), BRAF(6), CALM1(1), CBL(1), CBLB(1), CBLC(1), ELK1(1), EXOC7(2), FASN(7), FBP1(2), FBP2(4), FLOT1(2), FOXO1(1), G6PC(2), GCK(2), GSK3B(1), GYS2(3), IKBKB(2), INPP5D(6), INSR(5), IRS1(4), IRS4(3), KRAS(1), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MAPK9(2), MKNK1(1), NRAS(1), PCK1(4), PCK2(1), PDE3A(1), PDE3B(4), PFKM(3), PFKP(6), PHKA1(3), PHKA2(4), PHKB(2), PIK3CA(19), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(17), PIK3R2(5), PIK3R5(2), PKLR(4), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3A(9), PPP1R3C(1), PPP1R3D(2), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(4), PYGB(4), PYGL(1), PYGM(2), RHOQ(3), RPS6KB1(1), SH2B2(3), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS4(2), SORBS1(2), SOS1(1), SOS2(4), SREBF1(2), TRIP10(4), TSC1(4), TSC2(2)	62263160	264	112	255	73	88	39	46	52	39	0	0.026	0.093
175	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(3), HLA-DRA(1), HLA-DRB1(2)	979062	7	6	5	1	1	2	0	4	0	0	0.027	0.096
176	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(9), AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), DAO(3), GAMT(1), GATM(2), GOT1(1), MAOB(1), NOS1(9), NOS3(5), OAT(1), ODC1(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1)	17401829	77	46	75	19	31	17	11	17	1	0	0.028	0.097
177	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(1), DLD(1), DLST(2), IDH1(15), IDH2(2), IDH3G(2), MDH2(1), PC(3), PCK1(4), SUCLA2(1), SUCLG1(2)	8250379	36	26	23	14	17	5	10	4	0	0	0.028	0.097
178	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(2), ARSD(1), ARSE(1), CARM1(1), CYP11B2(4), CYP19A1(3), HSD11B1(2), HSD17B3(1), HSD17B7(1), HSD17B8(1), HSD3B2(2), LCMT1(1), PRMT6(5), PRMT7(2), PRMT8(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3)	19047587	66	45	61	32	19	8	22	13	4	0	0.028	0.098
179	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(1), TAT(3), TYR(5)	1908974	10	9	10	1	1	3	2	4	0	0	0.029	0.10
180	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F5(9), F7(1), FGA(3), FGB(1), FGG(4), PROC(2), SERPINC1(2)	6457793	24	19	24	9	7	5	6	1	5	0	0.037	0.13
181	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1)	4433802	24	15	23	13	8	2	7	2	5	0	0.038	0.13
182	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(2), LRP8(2), RELN(20), VLDLR(2)	5680593	27	18	27	18	10	8	1	3	5	0	0.047	0.16
183	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(8), DFFA(1), DFFB(3), GZMA(1), GZMB(3), PRF1(3)	4170990	21	15	21	5	4	3	6	4	4	0	0.050	0.17
184	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(3), CTH(1), GOT1(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MPST(1), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(1), SULT4A1(1)	5047540	24	16	24	4	3	6	7	4	4	0	0.052	0.17
185	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), RPS6KB1(1), STAT6(3)	5883058	23	18	22	6	8	3	3	7	2	0	0.052	0.17
186	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(1), CD3G(1), CD4(3), ITGAL(4), ITGB2(5), PTPRC(4)	4539789	19	14	17	13	4	2	3	3	7	0	0.055	0.18
187	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1)	2311758	13	9	13	2	8	0	3	2	0	0	0.058	0.19
188	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(4), GOT1(1), NOS1(9), NOS3(5), OAT(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(1), RARS2(1)	14085749	55	36	53	16	23	8	11	12	1	0	0.058	0.19
189	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), KERA(2), LUM(3)	1446169	7	7	6	4	2	2	1	0	2	0	0.062	0.20
190	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(4), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(5), NFATC1(3), NFATC2(1), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SYT1(1), VIP(1), VIPR2(2)	10901738	36	28	35	16	7	4	4	12	9	0	0.063	0.20
191	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(1), ABLIM2(1), ABLIM3(2), CFL2(1), DCC(9), DPYSL2(2), DPYSL5(2), EFNA3(2), EFNA5(2), EFNB1(2), EFNB2(2), EFNB3(1), EPHA1(6), EPHA2(2), EPHA3(2), EPHA4(3), EPHA5(4), EPHA6(2), EPHA7(6), EPHA8(6), EPHB1(10), EPHB2(6), EPHB3(1), EPHB4(2), EPHB6(5), FES(3), GNAI2(1), GSK3B(1), KRAS(1), L1CAM(7), LIMK1(1), LIMK2(1), LRRC4C(3), MAPK1(3), MAPK3(2), MET(5), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), NRP1(5), NTN1(3), NTN4(2), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLXNA1(3), PLXNA2(8), PLXNA3(3), PLXNB1(3), PLXNB2(7), PLXNB3(7), PLXNC1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTK2(2), RGS3(2), RHOA(1), RHOD(1), RND1(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(4), SEMA3A(1), SEMA3B(1), SEMA3C(8), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(3), SEMA4G(3), SEMA5A(2), SEMA5B(2), SEMA6B(1), SEMA6C(1), SEMA7A(1), SLIT1(4), SLIT2(5), SLIT3(14), SRGAP1(5), SRGAP2(2), SRGAP3(4), UNC5A(4), UNC5D(2)	75489230	269	124	260	90	73	46	60	53	37	0	0.069	0.22
192	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1)	4933029	23	16	22	14	7	2	6	4	2	2	0.070	0.22
193	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), COMT(2), DBH(6), DDC(1), ESCO1(2), FAH(1), GOT1(1), HPD(1), LCMT1(1), MAOB(1), MYST3(4), MYST4(4), PNMT(1), PNPLA3(1), PRMT6(5), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(3), TPO(4), TYR(5), TYRP1(2)	23393403	91	56	85	23	40	11	17	18	5	0	0.071	0.22
194	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(3), CD8A(1), EPO(1), IL2(1), IL4(1), IL6(2), IL7(1)	2405698	10	9	8	2	3	1	0	5	1	0	0.071	0.22
195	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(1), AKT2(1), AKT3(1), ANKRD6(3), APC(7), AXIN1(2), AXIN2(1), DACT1(5), DKK1(1), DKK2(3), FSTL1(2), GSK3B(1), LRP1(15), MVP(2), NKD2(2), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2)	15524662	58	37	52	11	18	3	15	14	8	0	0.071	0.22
196	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), IL6(2), LDLR(4)	2160204	8	8	8	3	1	1	3	2	1	0	0.071	0.22
197	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(4), GPAM(2), GPD1(2), GPD2(1), LCAT(1), MYST3(4), MYST4(4), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1), PTDSS2(1), SH3GLB1(2)	26083469	95	56	89	26	30	11	20	18	14	2	0.076	0.24
198	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(1), JAK1(3), JAK2(4), PLA2G2A(5), PTPRU(3), STAT1(1)	4635935	18	15	13	1	9	0	6	1	2	0	0.076	0.24
199	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(4), ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(4), CACNA1B(7), GNAS(3), GNAT3(3), GNB1(1), GNB3(1), GRM4(5), ITPR3(11), KCNB1(3), PDE1A(1), PLCB2(5), PRKACG(1), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R14(2), TAS2R16(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R41(3), TAS2R42(1), TAS2R60(1), TAS2R8(1), TRPM5(1)	21727627	89	52	88	45	39	11	16	14	9	0	0.079	0.24
200	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(2), ENPP3(1), NADSYN1(4), NMNAT2(1), NNMT(1), QPRT(3)	5902823	19	17	16	2	8	2	2	6	1	0	0.080	0.25
201	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(1), CD4(3), HLA-DRA(1), HLA-DRB1(2), PTPRC(4), ZAP70(5)	3681922	17	12	15	6	4	4	2	4	3	0	0.083	0.25
202	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(2), ACADS(4), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), SDS(4)	10403076	48	27	48	14	13	12	7	9	7	0	0.084	0.25
203	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(4), JAK3(4), MAPK1(3), MAPK3(2), STAT3(2), TYK2(3)	4692033	21	16	19	3	9	3	3	5	1	0	0.084	0.25
204	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), GAMT(1), GATM(2), OAT(1), ODC1(1), OTC(2)	6769060	24	19	23	5	7	5	4	7	1	0	0.085	0.26
205	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD3E(1), CD3G(1), CD4(3), CXCR3(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(4), STAT4(1), TYK2(3)	5635956	25	17	22	9	11	1	5	4	4	0	0.088	0.27
206	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(1)	1952432	8	8	6	1	6	0	1	1	0	0	0.090	0.27
207	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(9), AOC2(2), AOC3(2), CES1(2)	2419051	15	10	15	1	8	3	1	3	0	0	0.093	0.28
208	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(9), ACY3(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AMDHD1(3), AOC2(2), AOC3(2), CARM1(1), CNDP1(4), DDC(1), FTCD(3), HAL(2), HARS(3), HARS2(1), HDC(3), HNMT(1), LCMT1(1), MAOB(1), PRMT6(5), PRMT7(2), PRMT8(1), PRPS2(2), UROC1(2)	15763597	61	41	57	17	29	5	11	14	2	0	0.095	0.28
209	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(2), ACO2(1), CLYBL(3), DLD(1), DLST(2), IDH1(15), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), OGDHL(5), PC(3), PCK1(4), PCK2(1), SUCLA2(1), SUCLG1(2)	11972976	48	31	35	17	22	6	13	6	1	0	0.10	0.30
210	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(3), HLA-DRA(1), HLA-DRB1(2), IL4(1), IL5RA(1), IL6(2)	2187762	12	8	10	2	2	3	0	5	2	0	0.10	0.30
211	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(2), ACTN3(1), ACTN4(4), DES(3), DMD(11), FAM48A(5), MYBPC1(2), MYBPC2(1), MYBPC3(3), MYH3(6), MYH6(5), MYH7(3), MYH8(8), MYL2(2), MYOM1(3), NEB(11), TNNI1(2), TNNT1(2), TNNT2(1), TPM1(1), TPM3(1), TPM4(1), TTN(110), VIM(1)	50708337	190	87	186	62	65	36	45	31	13	0	0.10	0.30
212	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), LPO(1), MPO(3), PRDX2(2), TPO(4), TYR(5)	3807130	21	14	21	8	11	1	2	4	3	0	0.10	0.30
213	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCL3(1), CCR1(2), CCR3(2), CCR4(1), CCR7(2), CD28(1), CD4(3), CXCR3(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL4(1), IL4R(6), TGFB1(1), TGFB2(1)	7533077	37	21	35	7	12	3	8	8	6	0	0.10	0.30
214	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), ESR1(3), ESR2(1), ESRRA(2), HNF4A(7), NPM1(1), NR1D1(3), NR1H2(1), NR1H3(1), NR1I3(2), NR2F2(2), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(2), NR5A1(1), NR5A2(1), PGR(4), PPARA(1), RARA(5), RARG(2), ROR1(2), RORA(1), RORC(3), RXRA(3), RXRB(1), RXRG(1), THRA(1), VDR(2)	16770470	63	41	58	28	20	3	11	16	13	0	0.11	0.31
215	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), NAGLU(1), SPAM1(6)	8100775	32	22	31	10	12	2	6	6	6	0	0.11	0.32
216	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), NOS1(9), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SYT1(1)	9871541	44	29	42	19	20	3	8	11	2	0	0.12	0.33
217	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ABP1(9), ACADM(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), UPB1(1)	10880045	46	28	46	9	17	7	8	11	3	0	0.12	0.33
218	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(2), AP2M1(4), BIN1(1), CALM1(1), DNM1(5), EPN1(1), EPS15(1), PICALM(2), PPP3CB(1), SYNJ1(1), SYNJ2(7), SYT1(1)	8612476	33	21	32	7	9	6	8	3	7	0	0.12	0.33
219	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	1940571	9	7	9	2	0	4	1	1	3	0	0.12	0.33
220	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(1), C6(4), C7(6), IL6(2), ITGA4(7), ITGAL(4), ITGB2(5), SELP(2), SELPLG(2)	9840865	41	25	40	26	13	3	7	8	8	2	0.12	0.33
221	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3E(1), CD3G(1), CD4(3), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8965084	41	26	39	12	14	8	7	7	5	0	0.12	0.33
222	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3E(1), CD3G(1), CD4(3), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8965084	41	26	39	12	14	8	7	7	5	0	0.12	0.33
223	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(2), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CLCA1(3), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(2), CNGB1(5), GNAL(1), GUCA1B(1), GUCA1C(3), PDE1C(4), PRKACG(1), PRKG2(5), PRKX(2)	12240769	45	30	44	22	13	7	11	11	3	0	0.12	0.33
224	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT4(1), FUT1(1), FUT5(2), FUT6(2), FUT7(5), FUT9(1), GCNT2(1), ST3GAL6(2)	6213807	27	18	23	9	8	3	9	6	1	0	0.12	0.33
225	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(2), ABCB4(8), ABCC1(3), ABCC3(5), GSTP1(1)	5751848	23	18	23	12	9	4	2	4	4	0	0.12	0.33
226	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), GK(1), GLA(1), GLB1(1), LCT(8), LIPC(1), LIPG(5), PNLIP(2), PNLIPRP1(2), PPAP2C(1)	18858900	84	44	83	21	34	14	17	12	7	0	0.12	0.33
227	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	468602	2	2	2	1	0	0	1	0	1	0	0.12	0.34
228	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(9), FASN(7), MCAT(1), OXSM(3)	5930850	28	17	28	7	11	1	8	5	3	0	0.13	0.35
229	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ITGA4(7), ITGAL(4), ITGB2(5), PECAM1(2), SELE(1)	5304269	23	14	23	13	7	1	4	6	5	0	0.13	0.35
230	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(4), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2)	12777875	58	33	54	16	28	6	10	10	4	0	0.13	0.36
231	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR109B(3), GPR161(2), GPR18(1), GPR34(1), GPR45(2), GPR65(1), GPR68(2), GPR81(2)	3922283	16	12	16	5	6	2	2	4	2	0	0.13	0.36
232	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), PIAS3(4), PTPRU(3), SRC(2), STAT3(2)	6157097	26	19	23	4	12	4	3	5	2	0	0.14	0.37
233	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP5(2), ACP6(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CMBL(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHRS7(1), PON1(4), PON3(2)	6896273	31	19	31	7	12	3	7	8	1	0	0.14	0.37
234	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(1), ALOX15(2), ALOX15B(1), ALOX5(1), CBR1(1), CBR3(2), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP4A11(3), CYP4A22(4), CYP4F2(5), CYP4F3(5), EPHX2(2), GGT1(2), GPX1(2), GPX2(1), GPX5(2), LTA4H(1), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3)	15495569	73	38	68	28	31	6	20	9	5	2	0.14	0.37
235	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(3), TGM2(9)	2026871	13	8	11	4	3	0	4	4	2	0	0.14	0.37
236	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(9), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DDC(1), HAL(2), HARS(3), HDC(3), HNMT(1), MAOB(1), PRPS2(2)	9896289	48	27	48	9	24	9	5	8	2	0	0.14	0.37
237	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(9), AGXT2(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PISD(3), PLCB2(5), PLCG1(3), PLCG2(11), PSPH(2), SARDH(6), SHMT2(1), TARS(2)	16846339	74	40	71	18	29	14	16	8	7	0	0.14	0.37
238	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(3), STAT1(1), STAT2(5), TYK2(3)	4326909	14	12	14	3	4	2	5	1	2	0	0.14	0.37
239	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4)	8067047	29	21	28	9	14	1	5	4	5	0	0.14	0.37
240	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), CHRM2(4), CHRM3(3), DRD1(2), DRD2(1), DRD3(1), DRD5(4), HRH1(1), HRH2(5), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1)	9718968	48	29	48	18	23	5	8	8	4	0	0.15	0.38
241	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(2), ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF2(1), ATF4(1), ATP2A2(2), ATP2A3(4), CACNB3(1), CALCA(3), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CNN2(1), CORIN(5), CREB3(1), CRHR1(2), DGKZ(5), FOS(1), GABPA(1), GJA1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), GSTO1(3), GUCA2B(1), GUCY1A3(5), IGFBP1(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(7), ITPR2(11), ITPR3(11), MIB1(2), MYL2(2), MYLK2(1), NFKB1(1), NOS1(9), NOS3(5), OXTR(2), PDE4B(1), PDE4D(3), PLCB3(5), PLCD1(1), PLCG1(3), PLCG2(11), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RAMP3(2), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR2(36), RYR3(17), SLC8A1(2), SP1(6), TNXB(6), USP5(5), YWHAB(1)	67503813	291	119	285	92	127	35	54	44	31	0	0.15	0.38
242	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	3532572	12	11	12	7	6	3	2	0	1	0	0.15	0.38
243	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	3532572	12	11	12	7	6	3	2	0	1	0	0.15	0.38
244	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(1), CD3G(1), CD8A(1), ITGAL(4), ITGB2(5), PTPRC(4)	4298928	17	12	17	12	5	2	3	0	7	0	0.15	0.39
245	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(3), HLA-DRA(1), HLA-DRB1(2), IL2(1), IL4(1)	1633088	9	6	7	1	2	2	0	5	0	0	0.16	0.39
246	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(3)	1070053	4	4	4	0	1	2	1	0	0	0	0.16	0.39
247	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGAT2(2), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), GK(1), GK2(2), GLA(1), GLB1(1), GPAM(2), LCT(8), LIPC(1), LIPG(5), MGLL(2), PNLIP(2), PNLIPRP1(2), PNPLA3(1), PPAP2C(1)	23080983	89	50	88	25	37	11	17	16	8	0	0.16	0.40
248	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1R1(2), IRAK1(2), MAP3K1(5), MAP3K14(2), MAP3K7(2), NFKB1(1), NFKBIA(2), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2)	9716920	29	22	28	14	4	5	6	10	4	0	0.16	0.40
249	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA(1), LPO(1), MPO(3), TPO(4)	3329226	15	12	15	7	11	0	0	1	3	0	0.16	0.40
250	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), ENPP2(5), PAFAH2(2), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLD2(1), PPAP2C(1)	9352222	38	24	34	17	13	3	9	5	6	2	0.17	0.41
251	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), DHFR(1), FPGS(2)	2450112	11	9	11	4	4	0	4	2	1	0	0.17	0.41
252	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(2), AGT(3), AGTR1(2), AGTR2(1), ANPEP(3), CTSA(2), CTSG(4), ENPEP(9), LNPEP(2), NLN(1), REN(2), THOP1(1)	8431879	39	22	39	13	17	5	8	3	6	0	0.17	0.41
253	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	GUSB(3), RPE(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5)	6320515	18	16	18	11	4	5	3	3	3	0	0.17	0.41
254	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL2RA(3), IL4(1), IL4R(6)	5130651	28	15	28	4	12	5	4	5	2	0	0.17	0.41
255	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(3), EPHB1(10), ITGA1(1), L1CAM(7), LYN(1), RAP1B(2), SELP(2)	6284921	27	17	26	8	11	5	6	3	2	0	0.17	0.41
256	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), PRDX2(2), TAT(3), TPO(4)	8803849	43	26	43	10	23	5	4	8	3	0	0.17	0.41
257	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(1), BLVRB(1), CP(4), CPOX(1), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UROD(1), UROS(1)	10330169	38	24	38	16	10	4	6	12	6	0	0.18	0.43
258	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRA1D(1), ADRB1(1), ADRB2(1), ATP1A4(1), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1S(12), CACNB3(1), CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CASQ2(1), CHRM2(4), CHRM3(3), GJA1(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GNA11(2), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNB1(3), KCNJ3(2), KCNJ5(3), MIB1(2), NME7(3), PLCB3(5), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR2(36), RYR3(17), SLC8A1(2), SLC8A3(2), USP5(5), YWHAB(1)	73557180	302	123	297	109	136	38	50	50	28	0	0.18	0.43
259	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(1), GSS(1), NFKB1(1), NOX1(2), XDH(8)	4061497	15	11	14	5	2	3	7	1	2	0	0.18	0.43
260	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(6), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(4), GRIA3(5), GRID2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IGF1R(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NOS1(9), NOS3(5), NPR1(6), NPR2(1), NRAS(1), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(3), PRKCG(1), PRKG2(5), RYR1(14)	43885422	177	83	162	64	67	22	32	30	22	4	0.18	0.43
261	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(4), ELK1(1), FOS(1), IKBKB(2), IRAK1(2), LY96(1), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), PPARA(1), TLR10(1), TLR2(4), TLR4(1), TLR6(6), TLR7(5), TLR9(2)	14541644	47	32	46	25	9	13	8	12	5	0	0.18	0.43
262	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(8), DVL2(2), EDNRB(1), EP300(6), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GSK3B(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MITF(2), NRAS(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), TCF7(3), TCF7L2(3), TYR(5), TYRP1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4)	42357653	177	82	173	50	59	21	39	31	23	4	0.18	0.43
263	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1), NTAN1(1), SIRT1(2), SIRT2(2), VNN2(1)	4653069	13	11	13	1	2	2	1	2	6	0	0.19	0.44
264	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(8), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SDS(4), SUCLA2(1), SUCLG1(2)	13418593	50	29	50	11	12	13	10	6	9	0	0.19	0.44
265	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(7), CDC25B(1), CHEK1(5), MYT1(7)	5572706	20	13	20	0	6	3	2	4	5	0	0.19	0.44
266	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME3(3), PGK2(3), PKLR(4), RPE(1), TKT(2), TKTL1(2), TKTL2(2)	7845277	34	21	34	8	11	5	7	8	3	0	0.20	0.45
267	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), NR3C1(1), RETN(1), RXRA(3)	2319283	7	7	7	4	1	2	0	1	3	0	0.20	0.46
268	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3)	9003646	30	21	29	12	6	3	6	11	4	0	0.20	0.46
269	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(2), ABCA12(2), ABCA13(6), ABCA2(3), ABCA3(3), ABCA4(6), ABCA5(4), ABCA6(2), ABCA7(3), ABCA8(1), ABCA9(4), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(8), ABCB5(7), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(2), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(5), ABCC4(4), ABCC5(7), ABCC6(5), ABCC8(6), ABCC9(12), ABCD1(4), ABCD2(4), ABCD3(3), ABCG1(2), ABCG2(2), ABCG4(6), ABCG5(3), ABCG8(3), CFTR(7), TAP1(4), TAP2(2)	46607696	167	77	166	58	57	18	38	23	24	7	0.20	0.46
270	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), C9orf95(1), CD38(2), ENPP3(1), NADK(3), NADSYN1(4), NMNAT2(1), NNMT(1), NT5C1B(3), NT5C2(2), QPRT(3)	8700021	28	21	25	8	10	2	5	9	2	0	0.20	0.46
271	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE1(1), CCNE2(1), CDKN1B(3), CDKN2A(3), E2F2(3)	3378480	12	11	12	8	3	3	1	1	4	0	0.20	0.46
272	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3)	4182675	17	12	16	5	10	2	3	1	1	0	0.21	0.47
273	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3)	4182675	17	12	16	5	10	2	3	1	1	0	0.21	0.47
274	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CD44(4), FCGR3A(1), IL6R(2), TGFB1(1), TGFB2(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(3), TNFSF8(1)	5271297	24	14	24	7	6	4	6	3	5	0	0.22	0.49
275	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNB1(1), IKBKB(2), IL1R1(2), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(2), IRAK2(3), IRAK3(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), TGFB1(1), TGFB2(1)	11783783	37	26	36	16	5	5	5	13	9	0	0.22	0.50
276	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	APH1A(3), CREBBP(8), CTBP1(3), CTBP2(4), DLL3(1), DTX1(1), DTX3L(1), DVL2(2), EP300(6), HDAC1(1), HDAC2(3), HES1(1), JAG1(3), JAG2(5), LFNG(1), MAML1(3), MAML2(2), MAML3(1), MFNG(2), NCOR2(5), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMB(1), NUMBL(2), PSEN2(1), RBPJ(1), RBPJL(4), SNW1(1)	25862211	88	52	85	29	27	12	20	15	12	2	0.23	0.52
277	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(2)	10143840	39	26	37	13	15	10	4	4	6	0	0.23	0.52
278	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(1), FOS(1), IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2), STAT3(2)	9560632	34	23	32	6	11	5	6	8	4	0	0.24	0.52
279	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(1), IL12B(1), IL2(1)	1206627	7	4	7	0	1	2	0	2	2	0	0.24	0.52
280	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(3), SCAP(5), SREBF1(2), SREBF2(3)	4554029	18	12	18	6	7	2	4	0	5	0	0.24	0.52
281	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(5), TYK2(3)	5024612	16	14	16	4	7	1	5	1	2	0	0.24	0.53
282	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SPTLC1(3), SPTLC2(1), UGCG(1)	9552915	36	23	35	15	12	5	4	4	9	2	0.25	0.54
283	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(6), CREB3(1), CREB5(1), MAPK1(3), SNX13(1), SRC(2), TERF2IP(3)	4440672	18	11	15	2	2	3	3	9	1	0	0.25	0.54
284	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), PON1(4)	11601263	49	29	49	17	21	2	14	11	1	0	0.25	0.55
285	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(2), ALOX5(1), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP3A4(3), CYP3A43(2), CYP3A7(3), PLA2G12A(3), PLA2G2A(5), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), RDH13(1)	9624747	44	22	40	13	15	2	13	8	4	2	0.25	0.55
286	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(1), NAT2(1), XDH(8)	3252534	12	10	12	4	3	2	4	1	2	0	0.26	0.56
287	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(9), AGXT2(2), AKR1B10(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PHGDH(1), PIPOX(2), PISD(3), PSPH(2), RDH13(1), SARDH(6), SARS2(2), SDS(4), SHMT2(1), TARS(2), TARS2(1)	17182900	68	38	64	15	23	14	17	7	7	0	0.26	0.56
288	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), CHST1(2), CHST2(3), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL3(1)	4837895	20	14	20	5	6	6	2	5	1	0	0.26	0.56
289	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CAMKK1(3), CAMKK2(1), SYT1(1)	4626443	15	13	15	6	3	1	2	6	3	0	0.26	0.56
290	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4)	19416741	88	44	87	15	42	14	13	13	6	0	0.26	0.56
291	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4)	19416741	88	44	87	15	42	14	13	13	6	0	0.26	0.56
292	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(12), CALM1(1), CAPN2(1), CAPNS1(1), EP300(6), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(3), NFATC2(1), PPP3CB(1), PRKCA(3), SYT1(1)	9559706	35	22	35	10	9	3	8	9	4	2	0.27	0.56
293	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	207423	1	1	1	0	1	0	0	0	0	0	0.27	0.57
294	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2B(1), ADORA3(1), P2RY1(1), P2RY2(2), P2RY6(2)	2363953	9	8	9	1	3	0	2	2	2	0	0.27	0.58
295	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME2(2), ME3(3), PKLR(4), RPE(1), TKT(2)	6979042	29	18	29	6	10	3	6	8	2	0	0.28	0.58
296	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4)	14781438	56	32	56	14	17	10	12	10	7	0	0.28	0.58
297	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(1)	620625	2	2	2	0	0	0	1	1	0	0	0.28	0.58
298	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1)	6877628	28	17	27	20	9	3	7	5	2	2	0.28	0.58
299	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), TNFAIP3(1), TRAF3(3)	7318170	24	16	23	9	3	3	4	10	4	0	0.28	0.58
300	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C8B(5), C9(1), MASP1(2)	8218368	35	20	34	21	10	5	9	7	2	2	0.28	0.58
301	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4)	6545653	23	15	22	7	11	1	3	4	4	0	0.28	0.58
302	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), CDKN1A(1), CHEK1(5), NEK1(2)	2788786	9	7	9	1	1	1	2	3	2	0	0.30	0.60
303	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1(2), ELK1(1), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NCF1(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PAK1(2), PIK3C2G(9), PLCB1(4), PPP3CB(1), SYT1(1)	15238833	54	30	54	19	10	7	11	15	9	2	0.30	0.60
304	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(3), TNFSF11(4)	4476253	12	11	12	7	4	3	2	0	3	0	0.30	0.60
305	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK2(4), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(3), SOAT1(2)	5522242	22	15	19	4	12	1	4	4	1	0	0.30	0.61
306	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(2), ARSB(2), ARSD(1), ARSE(1), CYP11B2(4), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B2(2), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5)	10343168	33	23	33	22	10	6	7	6	4	0	0.31	0.62
307	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.31	0.62
308	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.31	0.62
309	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.31	0.62
310	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(3), BCMO1(2), RDH5(1)	1582419	10	5	10	1	3	5	1	0	1	0	0.31	0.62
311	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1)	4103160	15	11	15	5	4	1	3	5	2	0	0.31	0.62
312	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(8), EP300(6), NCOA3(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RARA(5), RXRA(3)	8142271	30	18	27	7	6	4	7	8	3	2	0.31	0.62
313	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SP1(6), SP3(1), SYT1(1)	8245499	26	19	26	11	4	4	4	8	6	0	0.32	0.63
314	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2)	2695597	11	7	11	1	2	3	2	2	2	0	0.32	0.64
315	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(1), PDE1A(1), PLCB1(4), PLCB2(5), PRL(3), TRH(1), VIP(1)	4434609	19	11	19	5	10	3	2	1	1	2	0.33	0.64
316	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(5), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2)	3035540	12	8	12	4	1	4	4	1	2	0	0.33	0.64
317	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	4899111	23	13	23	5	5	8	4	3	3	0	0.33	0.64
318	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	5388913	21	14	21	5	11	1	5	4	0	0	0.33	0.64
319	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(6), ESR1(3), MAPK1(3), MAPK3(2), PELP1(2), SRC(2)	5861877	26	14	26	4	6	5	8	4	1	2	0.33	0.64
320	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), MAPK1(3), MAPK3(2), MYT1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SRC(2)	7939238	31	19	31	7	14	3	5	6	3	0	0.33	0.64
321	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(6), APOE(1), CETP(2), HMGCR(1), LCAT(1), LDLR(4), LIPC(1), LRP1(15), SCARB1(1), SOAT1(2)	10040960	34	21	31	9	5	5	12	5	4	3	0.35	0.67
322	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(2), TAX1BP3(1), UBE2A(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2M(3), UBE3A(5)	4137499	16	10	16	1	3	2	5	1	3	2	0.35	0.67
323	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(3), HLA-DRA(1), HLA-DRB1(2), IFNB1(1), IFNG(1), IL12B(1), IL2(1), IL4(1), IL6(2), IL7(1), TGFB1(1), TGFB2(1)	5198747	16	12	14	5	2	3	1	6	4	0	0.35	0.67
324	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(3), GREB1(2), MTA1(4), MTA3(2), PDZK1(1), TUBA8(4)	4036321	18	10	18	7	7	2	5	1	3	0	0.35	0.67
325	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ACADVL(3), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CPT2(1), CYP4A11(3), CYP4A22(4), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1)	19720139	63	39	61	16	23	4	14	12	10	0	0.36	0.68
326	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TAL1(1), TALDO1(1), TKT(2)	8108679	38	20	38	7	16	7	3	8	4	0	0.36	0.68
327	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(1), IFNGR2(1), JAK1(3), JAK2(4), STAT1(1)	3343293	11	8	10	0	6	0	1	2	2	0	0.36	0.68
328	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLUD2(4)	1683449	7	5	7	2	3	0	3	0	1	0	0.36	0.68
329	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(2), GOT1(1), PAH(1), TAT(3), YARS(2)	3374325	10	9	10	4	4	2	2	2	0	0	0.37	0.69
330	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(8), ADCY8(4), ARAF(1), ATF4(1), BRAF(6), CACNA1C(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CREBBP(8), EP300(6), GNAQ(1), GRIA1(4), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NRAS(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RAP1B(2), RAPGEF3(1), RPS6KA2(2), RPS6KA3(5)	39543158	157	72	151	55	52	24	34	29	14	4	0.37	0.70
331	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP5(3), BMP6(3), BTRC(1), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(2), GLI1(4), GLI2(8), GLI3(3), GSK3B(1), HHIP(4), LRP2(28), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(2), SHH(2), SMO(2), STK36(2), SUFU(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4), ZIC2(1)	23802830	109	53	108	44	42	21	21	12	13	0	0.38	0.70
332	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1)	2556429	13	10	13	4	7	1	3	1	1	0	0.38	0.70
333	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(6), GLS(3), GOT1(1)	3019519	10	7	10	2	2	2	4	1	1	0	0.38	0.70
334	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(3), AGTR1(2), AGTR2(1), COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), REN(2)	10340714	39	23	37	11	13	11	6	5	4	0	0.38	0.70
335	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(1), CD3G(1), CXCR3(2), ETV5(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), JAK2(4), MAPK14(1), STAT4(1), TYK2(3)	7214838	26	17	25	11	11	1	7	2	5	0	0.38	0.70
336	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(4)	1930467	7	5	7	2	0	1	1	4	1	0	0.38	0.70
337	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ADC(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EARS2(2), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GFPT2(3), GLS(3), GLUD2(4), GLUL(1), GMPS(1), GOT1(1), GSR(1), GSS(1), NADSYN1(4), NAGK(2), QARS(3)	15751750	60	32	60	13	14	9	15	17	3	2	0.38	0.70
338	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(1)	2728774	9	7	9	6	2	1	3	2	1	0	0.39	0.70
339	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), DFFB(3), GZMB(3), TOP2A(1), TOP2B(1)	3551959	9	8	9	2	2	0	2	3	2	0	0.39	0.70
340	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6464244	27	16	27	8	9	6	8	1	3	0	0.39	0.70
341	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(6), LPO(1), MPO(3), MTHFR(3), SHMT2(1), TPO(4)	4632196	18	13	18	9	12	0	2	1	3	0	0.39	0.70
342	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(1), ALOX5(1), DPEP1(3), GGT1(2), LTA4H(1), PLA2G2A(5), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3)	5851365	24	15	20	7	8	4	6	2	4	0	0.39	0.71
343	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1C1(3), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(7)	12995770	54	29	54	22	27	5	9	3	10	0	0.40	0.71
344	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(3), GALNT2(4), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), ST3GAL1(2), WBSCR17(7)	5757903	29	15	29	14	15	4	6	1	3	0	0.40	0.71
345	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(5), AMY2B(1), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHX58(2), ENPP3(1), EP400(15), ERCC2(1), ERCC3(2), G6PC(2), GAA(3), GANC(1), GBA(1), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), IFIH1(2), MGAM(7), MOV10L1(2), PGM3(2), PYGB(4), PYGL(1), PYGM(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SI(3), SKIV2L2(1), SMARCA2(5), SMARCA5(2), TREH(2), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UXS1(1)	48283018	159	79	156	56	56	23	34	28	18	0	0.40	0.71
346	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2), TOB1(2), TOB2(1)	4320259	22	10	22	3	5	3	4	3	7	0	0.40	0.72
347	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(4), PC(3), PDHA1(1), SLC25A11(3)	3635305	13	9	13	5	3	1	4	4	1	0	0.41	0.73
348	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), NOX1(2), PIK3C2G(9), PLCB1(4), PPP1R12B(6), PRKCA(3), PTK2(2), ROCK2(4)	10057245	47	20	47	10	12	7	12	11	3	2	0.41	0.73
349	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GLS(3), GLUL(1), GMPS(1), GOT1(1), GSS(1), NADSYN1(4), QARS(3)	13204749	46	26	46	9	10	9	11	13	3	0	0.41	0.73
350	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), BCL2(3), CABIN1(12), CALM1(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(2), CREBBP(8), CSNK2A1(3), EGR2(3), EGR3(4), EP300(6), FCER1A(3), FCGR3A(1), FOS(1), GATA3(2), GATA4(2), GRLF1(4), GSK3B(1), IFNB1(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), IL6(2), ITK(3), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(3), P2RX7(2), PAK1(2), PPP3CB(1), PPP3R1(1), PTPRC(4), SLA(1), SP1(6), SP3(1), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(6), VAV2(3), VAV3(2), XPO5(1)	35624234	138	62	138	39	36	21	33	23	23	2	0.42	0.73
351	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), BIRC3(1), DFFA(1), DFFB(3), GZMB(3), PRF1(3), SCAP(5), SREBF1(2), SREBF2(3)	7117067	23	16	23	9	8	1	4	4	6	0	0.43	0.74
352	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(1), ALDOC(3), DERA(2), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKT(2), TKTL1(2), TKTL2(2)	9580655	43	22	43	7	18	6	6	8	5	0	0.43	0.74
353	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(2), ALAS2(1), CPOX(1), FECH(3), HMBS(1), PPOX(2), UROD(1), UROS(1)	3096938	12	8	12	1	2	1	3	3	3	0	0.43	0.74
354	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(3), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SGMS1(1), SGMS2(1), SMPD3(1), SPHK1(1), SPHK2(2), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(2)	13885751	47	29	45	18	16	8	6	5	10	2	0.43	0.75
355	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3)	2740861	9	8	9	4	5	0	0	1	3	0	0.43	0.75
356	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(2), ACP6(2), ACPT(3), ENPP3(1), LHPP(1), MTMR1(2), MTMR2(3), RFK(1), TYR(5)	6011045	20	12	20	5	4	4	4	6	2	0	0.43	0.75
357	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), FARSB(1), GOT1(1), PAH(1), TAT(3), YARS(2), YARS2(2)	3538569	11	9	11	2	2	4	3	2	0	0	0.44	0.75
358	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDPS(2), HMGCR(1), LSS(1), MVD(1), MVK(1), NQO2(1), PMVK(1), SC5DL(2), SQLE(1)	4352042	15	10	14	1	6	0	3	3	3	0	0.44	0.75
359	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(1), ABP1(9), ACMSD(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), KYNU(3), MAOB(1), SDS(4), TDO2(2), TPH1(3)	21968333	88	44	86	22	36	13	20	14	5	0	0.44	0.75
360	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(1), CERK(1), CREB3(1), CREB5(1), DAG1(2), EPHB2(6), FOS(1), GNAQ(1), ITPKB(2), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2)	11048405	40	24	40	11	12	4	10	9	5	0	0.44	0.75
361	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(9), ACOT12(1), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4)	18815701	65	37	65	20	22	6	16	13	8	0	0.44	0.75
362	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), ADRB2(1), CFTR(7), GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5000185	22	13	22	6	11	3	4	2	2	0	0.44	0.75
363	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(5), AMY2B(1), ENPP3(1), G6PC(2), GAA(3), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), MGAM(7), PGM3(2), PYGB(4), PYGL(1), PYGM(2), SI(3), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UXS1(1)	21856473	66	42	64	30	30	8	12	9	7	0	0.44	0.75
364	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(2), GAD1(4), GAD2(3), GGT1(2)	2278836	12	6	12	2	4	3	2	3	0	0	0.45	0.75
365	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), ESCO1(2), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(4)	13787304	54	32	54	11	25	7	5	11	6	0	0.45	0.76
366	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NGFR(1)	3196853	11	8	11	2	4	1	2	3	1	0	0.46	0.77
367	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(2), ACTR3(2), AKT1(1), ANGPTL2(2), CFL2(1), FLNA(14), FLNC(6), FSCN3(2), LIMK1(1), MYH2(13), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), VASP(2), WASF1(1)	18440072	72	39	72	23	29	8	16	9	10	0	0.46	0.77
368	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1), MASP1(2), MBL2(1)	8383457	31	18	30	23	9	3	8	7	2	2	0.46	0.77
369	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), GNAQ(1), ITPKB(2)	2334197	6	6	6	1	2	0	0	2	2	0	0.46	0.77
370	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(3), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFKB1(1), NSMAF(3), RIPK1(1), TNFRSF1A(2), TRAF2(2)	8274482	23	18	23	7	5	4	4	5	5	0	0.46	0.77
371	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAS1(2), ALAS2(1), CPO(3), FECH(3), GATA1(1), HMBS(1), UROD(1), UROS(1)	3207720	13	7	13	2	2	3	2	4	2	0	0.47	0.78
372	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(2), ACADS(4), ECHS1(1), HADHA(1)	2142674	8	5	8	2	3	1	2	1	1	0	0.47	0.78
373	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(2), ACADS(4), ACADVL(3), ACSL3(3), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1)	6771058	20	13	20	4	6	3	4	5	2	0	0.47	0.78
374	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(3), ADCY9(5), AK1(1), ARF4(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), GNAS(3), PLCG1(3), PLCG2(11), PRKCA(3), SEC61A1(1), TRIM23(1)	14879216	59	32	59	22	24	11	12	5	7	0	0.48	0.79
375	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(9), ACY1(1), ADC(2), AGMAT(1), ALDH18A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CPS1(6), GATM(2), MAOB(1), ODC1(1), OTC(2), SAT1(1), SAT2(1)	11918551	43	25	43	9	13	10	8	12	0	0	0.48	0.79
376	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS2(2), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PGM3(2), PKLR(4)	22858971	92	46	91	21	41	12	15	16	8	0	0.49	0.81
377	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2(3), BID(4), CASP8AP2(3), CES1(2)	4143460	13	9	10	0	2	1	3	5	2	0	0.50	0.81
378	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(4), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2)	4233734	15	10	15	9	5	1	4	2	3	0	0.50	0.81
379	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(2), ARHGDIB(4), CASP1(4), GZMB(3), PRF1(3)	5217895	17	11	17	7	3	4	2	4	4	0	0.50	0.81
380	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), SQLE(1)	1248932	3	3	3	0	1	0	0	2	0	0	0.50	0.81
381	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA4(1), ANXA5(1), CYP11A1(1), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(5), PRL(3), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS1(2), SCGB1A1(1), TBXAS1(3)	8177226	32	16	32	9	9	6	3	8	4	2	0.51	0.82
382	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(1), IL12B(1), IL16(4), IL2(1), IL4(1), IL6(2)	3964825	11	8	11	5	2	1	2	4	2	0	0.52	0.85
383	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(1), LEPR(1), PRKAA2(1), PRKAG1(2), PRKAG2(5)	5919449	18	12	18	3	8	1	5	1	3	0	0.53	0.85
384	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), B4GALT2(1), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GANC(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2), RDH13(1), UGP2(1)	15097310	59	32	55	14	30	5	11	8	5	0	0.53	0.85
385	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1)	4061066	14	9	14	4	5	4	1	0	4	0	0.53	0.85
386	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), IMPDH1(2), OAZ1(1), POLD1(3), POLG(4), PRPS2(2), RRM1(2)	4959256	15	10	14	6	4	2	3	3	3	0	0.53	0.85
387	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ABAT(2), ACADS(4), ACSM1(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(1), RDH13(1)	16399088	52	31	52	20	18	7	10	9	8	0	0.53	0.85
388	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(3), IL22RA1(1), JAK1(3), JAK2(4), JAK3(4), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), TYK2(3)	7302229	26	16	24	6	12	2	6	5	1	0	0.53	0.85
389	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM1(1), CCL2(2), FOS(1), GNAQ(1), MAPK14(1), PLCG1(3), PRKCA(3), PTK2B(1), SYT1(1)	5281234	14	11	14	9	3	2	2	6	1	0	0.54	0.85
390	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(3), DHCR7(4), FDPS(2), GGCX(1), HMGCR(1), HSD17B7(1), IDI2(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1), TM7SF2(2)	7681268	26	16	25	7	8	2	7	3	6	0	0.54	0.85
391	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1)	4066968	13	10	12	1	7	1	2	3	0	0	0.54	0.85
392	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(4), IFNG(1), IKBKB(2), IL2(1), IL4(1), MAP3K1(5), MAP3K5(1), MAPK14(1), NFKB1(1), NFKBIA(2), TNFSF9(3), TRAF2(2)	7816794	25	15	24	13	8	2	3	7	5	0	0.55	0.86
393	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(2), MAPK14(1), NFKB1(1), TNFRSF13B(2), TNFSF13B(2), TRAF2(2), TRAF3(3), TRAF5(1)	5745691	18	12	17	6	4	0	4	7	3	0	0.55	0.86
394	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(8), ACACB(9), ACADM(2), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLA2(1), SUCLG1(2)	16123336	52	29	52	13	16	7	13	8	8	0	0.55	0.86
395	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT2(1), DDOST(2), DPAGT1(1), FUT8(1), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), RPN1(1), ST6GAL1(4)	7750835	24	15	24	5	6	5	3	5	5	0	0.57	0.89
396	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAR2A(1), PRKAR2B(1)	5958974	25	15	25	6	12	1	6	4	2	0	0.57	0.89
397	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CHIT1(1), CMAS(1), CTBS(3), GFPT1(5), GFPT2(3), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), LHPP(1), MTMR1(2), MTMR2(3), NAGK(2), NPL(3), PGM3(2), UAP1(1)	11395607	43	23	40	9	12	3	12	8	6	2	0.57	0.89
398	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(2), ELOVL5(1), FADS1(1), FADS2(1), FASN(7), HADHA(1), PECR(1), SCD(2)	5319808	20	12	20	3	6	3	4	4	3	0	0.57	0.89
399	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(2), IL10RA(1), IL6(2), JAK1(3), STAT1(1), STAT3(2), STAT5A(2)	4931464	15	10	15	4	4	2	2	3	4	0	0.57	0.89
400	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CALM1(1), ELK1(1), FOS(1), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), MAP2K1(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RPS6KA3(5), SYT1(1)	13613042	43	27	43	15	12	6	8	12	5	0	0.58	0.89
401	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	3235255	15	8	15	3	5	5	3	2	0	0	0.58	0.89
402	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	3235255	15	8	15	3	5	5	3	2	0	0	0.58	0.89
403	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(2), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), MAPK8IP3(5), PAPPA(6), RPS6KA3(5), SOS1(1), SYK(2), VAV1(6), VAV2(3), VAV3(2)	12633746	48	26	48	14	18	9	9	8	4	0	0.58	0.89
404	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(6), HLA-DRA(1), HLA-DRB1(2), ITGAL(4), ITGB2(5), PTPRC(4)	5799042	27	11	26	13	6	6	7	1	7	0	0.58	0.89
405	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4)	2470997	8	5	8	5	2	1	1	3	1	0	0.58	0.89
406	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(1), ALDOC(3), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GAPDHS(2), GCK(2), GOT1(1), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6B(1), LDHC(1), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PKLR(4)	16619362	68	32	67	20	26	11	11	13	7	0	0.59	0.90
407	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	653274	2	2	2	0	0	1	1	0	0	0	0.60	0.91
408	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), ESRRA(2), HDAC5(4), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CB(1), SLC2A4(3), SYT1(1)	8008658	25	16	25	7	4	4	6	7	4	0	0.61	0.92
409	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(1), UXS1(1)	1560555	5	3	5	0	2	2	0	1	0	0	0.61	0.92
410	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2B(2), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(1), NCOA3(4), NCOR2(5), POLR2A(2), RARA(5), RXRA(3), TBP(2)	9687615	32	18	29	8	8	2	9	6	7	0	0.62	0.93
411	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(5), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), ATP7B(3), COX10(1), COX8A(1), NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2), PPA2(1), UQCRC1(3)	14093507	52	27	52	15	14	11	13	7	7	0	0.62	0.93
412	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(2), HLA-DRA(1), HLA-DRB1(2)	1233437	6	3	6	0	0	3	0	2	1	0	0.62	0.93
413	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(2)	827895	2	2	2	2	1	0	1	0	0	0	0.63	0.94
414	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), SOAT2(2)	9397592	38	19	38	9	16	10	8	4	0	0	0.63	0.94
415	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(2), VAMP2(1)	1301392	3	3	3	1	2	0	0	0	1	0	0.63	0.94
416	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(2), ACPT(3), ENPP3(1), RFK(1), TYR(5)	3874593	12	7	12	4	2	2	2	5	1	0	0.63	0.94
417	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1(3), ACVR1C(2), ACVR2A(5), ACVR2B(1), ACVRL1(2), AMHR2(3), BMP5(3), BMP6(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CDKN2B(1), COMP(1), CREBBP(8), CUL1(5), DCN(2), EP300(6), FST(2), GDF5(2), GDF6(1), GDF7(1), ID1(1), IFNG(1), INHBA(3), INHBB(2), INHBE(1), LEFTY1(5), LEFTY2(2), LTBP1(1), MAPK1(3), MAPK3(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(3), RBL2(1), RHOA(1), ROCK1(3), ROCK2(4), RPS6KB1(1), SMAD3(1), SMAD4(1), SMAD7(1), SMAD9(1), SMURF1(6), SP1(6), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), THBS1(3), THBS2(5), THBS3(1), THBS4(2), ZFYVE16(2), ZFYVE9(2)	39416944	137	63	134	36	32	27	31	27	18	2	0.63	0.94
418	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(4), NR1I3(2), PTGS1(2)	2149083	8	5	8	5	3	0	3	1	1	0	0.64	0.94
419	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), EIF4E(2), FBL(1), LDHA(2), LDHC(1), MAPK14(1), NCL(3)	3536753	14	7	14	3	4	1	1	5	3	0	0.64	0.95
420	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(6), LPO(1), MPO(3), PRDX2(2), SHMT2(1), TPO(4)	4676705	17	11	17	9	11	0	2	1	3	0	0.65	0.95
421	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(1), AFMID(3), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1)	5436982	14	11	14	7	7	1	4	2	0	0	0.65	0.95
422	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), FSHR(1), GNAS(3), XPO1(2)	3767123	14	10	14	3	8	1	3	1	1	0	0.66	0.95
423	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD28(1), DAG1(2), EPHB2(6), FBXW7(2), GRAP2(1), ITK(3), ITPKB(2), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLCG1(3), PTPRC(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(1), SOS2(4), VAV1(6), ZAP70(5)	21669826	76	39	76	28	25	11	13	15	12	0	0.66	0.95
424	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	3135228	8	6	8	4	0	3	1	1	3	0	0.66	0.95
425	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(4), ABO(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(4), B4GALT2(1), B4GALT4(1), B4GALT6(1), FUT1(1), FUT5(2), FUT6(2), FUT7(5), FUT9(1), GBGT1(2), GCNT2(1), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2), ST3GAL1(2), ST3GAL3(1), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1)	19100973	75	36	71	19	22	8	26	14	5	0	0.66	0.95
426	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(2), AGXT2(2), ASNS(1), CAD(6), GAD1(4), GAD2(3), GOT1(1), NARS(1), PC(3)	10342147	26	19	26	13	5	5	7	6	3	0	0.66	0.95
427	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(1), MMP9(2), RECK(1), TIMP3(2)	3004129	10	7	10	1	5	1	2	1	1	0	0.66	0.95
428	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(3), KARS(4)	2839594	9	5	9	3	0	2	1	4	2	0	0.66	0.96
429	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(1), CREBBP(8), EP300(6), ERCC3(2), ESR1(3), GRIP1(6), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), MEF2C(1), NCOR2(5), NRIP1(3), PELP1(2), POLR2A(2), TBP(2)	18281204	60	34	60	14	19	7	18	6	8	2	0.67	0.96
430	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(2)	1249454	4	3	4	2	1	1	0	0	2	0	0.67	0.96
431	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BCL2(3), BID(4), BIRC2(1), BIRC3(1), CASP6(1), DFFA(1), DFFB(3), DIABLO(1)	5449727	16	12	13	2	3	0	5	7	1	0	0.67	0.96
432	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(4), BIRC2(1), BIRC3(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), DFFA(1), DFFB(3), GZMB(3), LMNB1(1), LMNB2(3), PRF1(3)	7723788	28	16	28	7	4	5	5	8	6	0	0.67	0.96
433	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B2(2)	3278617	8	6	8	6	2	0	4	0	2	0	0.68	0.96
434	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(2), FOS(1), MAPK14(1), THBS1(3)	2982491	7	6	7	4	1	2	0	3	1	0	0.68	0.96
435	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(1), FUT9(1), GCNT2(1)	2428650	7	5	7	3	3	1	1	1	1	0	0.68	0.96
436	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2), SDS(4)	14547809	54	26	52	15	17	12	11	7	7	0	0.68	0.96
437	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	3366834	9	6	9	3	1	3	1	1	3	0	0.68	0.96
438	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), CDR1(2), DGKI(3), FAU(1), PIGK(3), RPL10(1), RPL11(1), RPL14(1), RPL15(1), RPL18A(2), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL39(1), RPL5(2), RPL8(1), RPLP0(2), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), RPSA(1), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(1)	20833415	61	34	60	25	20	10	14	5	12	0	0.69	0.96
439	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI2(1), SQLE(1)	1690221	4	3	4	0	1	0	0	2	1	0	0.69	0.96
440	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), PAK1(2), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), SRC(2), SYT1(1)	11397828	29	20	29	13	6	5	4	10	4	0	0.69	0.96
441	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(1), PCYT1A(1), PCYT1B(2), PRMT6(5), PRMT7(2), PRMT8(1)	5565883	13	11	9	5	3	0	8	1	1	0	0.69	0.97
442	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR2(2), SNAP23(1), SNAP25(2), SNAP29(1), STX11(1), STX19(1), STX2(1), STX3(1), STX4(1), STX5(2), STX7(1), STX8(1), TSNARE1(2), USE1(1), VAMP2(1), VAMP5(1)	6371131	20	12	20	7	6	3	1	5	5	0	0.70	0.97
443	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1)	4578927	13	10	12	2	7	1	2	3	0	0	0.70	0.97
444	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(3), CREBBP(8), EP300(6), MAP2K1(1), MAP3K7(2), MAPK3(2), SKIL(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5)	10432659	39	18	39	9	9	6	11	6	5	2	0.70	0.97
445	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), CALM1(1), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK14(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYK(2), SYT1(1), VAV1(6)	15272232	40	26	40	23	9	7	8	11	5	0	0.70	0.97
446	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(1), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1)	5187062	11	10	11	7	5	1	4	1	0	0	0.71	0.97
447	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), BCL2(3), DAXX(4), MAPKAPK2(1), MAPKAPK3(1)	4559228	11	9	11	4	2	1	4	2	2	0	0.71	0.97
448	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP54(1), SRPR(4)	3024644	6	5	6	2	2	0	2	0	2	0	0.71	0.98
449	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(4), FDPS(2), HMGCR(1), HMGCS1(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1)	5222852	16	9	15	3	5	0	5	3	3	0	0.71	0.98
450	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL14(1), RPL18A(2), RPL22L1(1), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL36A(1), RPL36AL(1), RPL39(1), RPL8(1), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(2), RPSA(1)	8850132	29	18	28	11	9	4	6	4	6	0	0.72	0.98
451	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), NDST1(2), NDST2(2), NDST3(2), NDST4(5)	8299249	37	17	37	7	10	5	10	5	7	0	0.72	0.99
452	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1)	2558268	9	7	9	1	5	1	2	1	0	0	0.73	0.99
453	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1)	2558268	9	7	9	1	5	1	2	1	0	0	0.73	0.99
454	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(7), AXIN1(2), CCND2(1), DVL2(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LDLR(4), MAPK9(2), PLAU(2), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), RHOA(1), TCF7(3), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT4(3), WNT5A(1)	23140736	82	43	79	26	27	7	18	14	16	0	0.73	0.99
455	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(5)	7433431	23	14	23	7	7	4	3	4	5	0	0.73	0.99
456	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	30	GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2F1(1), GTF2H4(1), GTF2IRD1(2), TAF1(4), TAF1L(14), TAF2(2), TAF4(2), TAF4B(1), TAF5(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(2), TAF9(1), TBPL2(2)	14193225	45	22	43	14	13	4	14	6	8	0	0.73	0.99
457	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), ABCG2(2), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1)	9335101	25	17	25	16	7	5	4	4	5	0	0.74	0.99
458	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(2), EP300(6), EPO(1), HIF1A(1), LDHA(2), NOS3(5), VHL(1)	6659170	19	11	19	9	4	0	5	6	2	2	0.74	0.99
459	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(4), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2)	3976029	12	8	12	9	5	1	2	1	3	0	0.74	0.99
460	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUD2(4), GLUL(1), HAL(2)	8479240	33	16	33	7	14	4	7	4	4	0	0.74	0.99
461	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(1), UGP2(1), UXS1(1)	1991565	6	3	6	0	2	2	1	1	0	0	0.74	0.99
462	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(2), EPHB2(6), F2(1), F2RL3(1), MAP2K5(1), MAPK1(3), MAPK7(3), PLD2(1), PTK2(2), RASAL1(3), SRC(2), TEC(5), VAV1(6)	10846676	37	21	37	12	12	8	9	6	2	0	0.75	0.99
463	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC1(2), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1)	2977124	7	5	7	2	3	1	2	0	1	0	0.75	0.99
464	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(8), EP300(6), IKBKB(2), MAP2K3(1), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), NR3C1(1), TGFBR1(1), TGFBR2(5), TLR2(4)	11876729	40	20	39	13	6	7	10	9	6	2	0.75	0.99
465	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(6), CREB3(1), CREB5(1), DUSP4(3), DUSP9(1), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NFKB1(1), RPS6KA2(2), RPS6KA3(5), SOS1(1), SOS2(4), TRAF3(3)	11863709	40	21	36	10	11	4	7	15	3	0	0.75	0.99
466	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ARHGEF2(6), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	20832705	69	38	65	27	21	9	14	19	6	0	0.75	0.99
467	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ARHGEF2(6), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	20832705	69	38	65	27	21	9	14	19	6	0	0.75	0.99
468	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), ADRB2(1), GNAS(3), PLCE1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5703176	22	12	22	3	9	3	4	3	3	0	0.76	1.00
469	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(7), BMPR1B(1), CCND2(1), CDKN1B(3), EGR1(2), ESR2(1), FSHR(1), LHCGR(1), MSH5(3), NCOR1(6), NR5A1(1), NRIP1(3), PGR(4), PTGER2(2), VDR(2), ZP2(2)	14056328	40	23	40	12	11	5	12	4	6	2	0.76	1.00
470	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(8), EP300(6), HDAC3(1), IKBKB(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2)	9036928	29	15	28	12	4	4	9	6	4	2	0.76	1.00
471	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	661770	1	1	1	1	1	0	0	0	0	0	0.76	1.00
472	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(9), AOC2(2), AOC3(2), CES1(2), DDHD1(1), ESCO1(2), MYST3(4), MYST4(4), PLA1A(1), PNPLA3(1), SH3GLB1(2)	10220356	31	19	31	6	11	5	5	6	4	0	0.76	1.00
473	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(3), THTPA(1)	2569519	7	4	7	1	2	1	2	1	1	0	0.77	1.00
474	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), CNR2(3), DNMT1(5), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1)	4337739	20	9	20	8	6	2	1	8	3	0	0.77	1.00
475	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), MIOX(1)	3423771	9	7	9	3	4	1	2	2	0	0	0.77	1.00
476	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUL(1), HAL(2)	7581930	29	14	29	6	12	4	5	4	4	0	0.77	1.00
477	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), DUSP14(1), EIF4E(2), IFNG(1), IL1R1(2), NR4A3(1), WDR1(2)	4340112	11	7	11	6	1	2	0	5	3	0	0.77	1.00
478	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), GABARAPL1(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(2), PRKAA2(1), ULK1(1), ULK2(6), ULK3(1)	8181741	23	13	23	5	4	2	7	5	5	0	0.78	1.00
479	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2)	9862884	28	17	28	6	10	3	6	5	4	0	0.79	1.00
480	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADHA(1), HSD17B10(1), HSD17B4(1), MECR(2)	3446007	6	5	6	1	1	1	0	2	2	0	0.79	1.00
481	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(1), NFKBIA(2)	4989920	15	9	13	3	6	2	3	3	1	0	0.79	1.00
482	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TRAF2(2)	9608353	26	17	25	16	6	3	5	7	5	0	0.79	1.00
483	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(1), ACADM(2), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), APOA2(1), APOA5(1), AQP7(2), CD36(2), CPT1A(1), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A11(3), CYP4A22(4), CYP8B1(2), EHHADH(2), FADS2(1), GK(1), GK2(2), HMGCS2(3), ILK(2), ME1(4), NR1H3(1), OLR1(3), PCK1(4), PCK2(1), PLTP(1), PPARA(1), RXRA(3), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A2(7), SLC27A4(2), SLC27A6(4), SORBS1(2), UBC(1), UCP1(1)	25986066	90	44	87	31	25	12	15	21	17	0	0.79	1.00
484	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(2), CDT1(1), DIAPH2(3), MCM10(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), NACA(7), PCNA(1), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), PRIM1(1), RFC1(3), RFC2(1), RFC3(1), RFC4(2), RFC5(1), RPA4(2), UBA52(1), UBB(1), UBC(1)	20051853	55	32	52	22	15	3	15	5	17	0	0.79	1.00
485	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(3), PDE6D(1)	1564927	4	3	4	1	0	1	2	0	1	0	0.79	1.00
486	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1)	530101	1	1	1	1	0	1	0	0	0	0	0.79	1.00
487	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1)	738713	1	1	1	0	1	0	0	0	0	0	0.79	1.00
488	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DAXX(4), DDIT3(1), ELK1(1), HMGN1(1), MAP3K1(5), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2)	14709253	38	23	38	8	10	6	5	10	5	2	0.80	1.00
489	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	851992	1	1	1	2	0	1	0	0	0	0	0.80	1.00
490	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(3), ABAT(2), ACY3(1), ADSSL1(1), AGXT2(2), ASNS(1), CAD(6), DLAT(1), DLD(1), GAD1(4), GAD2(3), GOT1(1), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1)	15040466	39	25	39	20	12	8	8	6	5	0	0.80	1.00
491	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AANAT(1), ABP1(9), ACMSD(1), AFMID(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), CYP1A1(1), CYP1B1(4), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), HSD17B10(1), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), MAOB(1), NFX1(3), OGDH(1), OGDHL(5), PRMT6(5), PRMT7(2), PRMT8(1), TDO2(2), TPH1(3)	24107439	75	42	69	25	33	8	17	12	5	0	0.80	1.00
492	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(5), CAPNS1(1), CDK5R1(1), GSK3B(1), MAPT(1), PPP2CA(1)	3492849	12	6	12	2	5	1	3	3	0	0	0.80	1.00
493	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), LCT(8), NAGLU(1)	5692197	17	10	17	7	7	0	3	3	4	0	0.81	1.00
494	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(4), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2)	6718112	21	12	20	4	11	1	5	3	1	0	0.81	1.00
495	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(2), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(6), PRKCA(3), ROCK1(3)	8359857	34	14	34	9	10	3	10	6	3	2	0.81	1.00
496	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1)	5466314	11	8	11	6	2	2	2	3	2	0	0.82	1.00
497	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	FURIN(1), NOTCH1(4)	3187804	5	5	3	2	0	0	0	5	0	0	0.82	1.00
498	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8)	6680545	21	11	20	10	4	4	5	3	3	2	0.82	1.00
499	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2RL3(1), GNB1(1), GNGT1(1), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), PLA2G4A(5), PLCB1(4), PRKCA(3), PTGS1(2), PTK2(2), SRC(2), SYK(2), TBXAS1(3)	9811189	34	16	34	8	11	5	5	7	2	4	0.83	1.00
500	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(7), AXIN1(2), BTRC(1), CREBBP(8), CSNK2A1(3), CTBP1(3), FZD1(1), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(6), WIF1(2)	11291036	38	19	38	10	11	4	8	9	6	0	0.83	1.00
501	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(1), LDHA(2), LDHC(1), MPST(1)	2737319	6	4	6	1	1	1	2	1	1	0	0.83	1.00
502	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(9), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), AKT1(1), AKT2(1), AKT3(1), CAMKK1(3), CAMKK2(1), CD36(2), CHUK(4), CPT1A(1), CPT1C(2), CPT2(1), G6PC(2), IKBKB(2), IRS1(4), IRS4(3), JAK1(3), JAK2(4), JAK3(4), LEPR(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK1(4), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKCQ(1), PTPN11(6), RXRA(3), RXRB(1), RXRG(1), SLC2A1(4), SLC2A4(3), STAT3(2), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2), TYK2(3)	32767225	117	54	112	39	42	14	23	19	19	0	0.83	1.00
503	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLG(4), POLH(2), POLI(2), POLK(1), POLL(2), POLM(1), POLQ(8), PRIM1(1), PRIM2(5), REV1(1), REV3L(6), RFC5(1)	16489008	52	24	47	17	11	7	15	7	10	2	0.83	1.00
504	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(8), GLI3(3), GSK3B(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(2), SUFU(2)	6443477	25	12	24	16	6	8	4	5	2	0	0.83	1.00
505	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	3357368	9	6	9	6	3	2	2	2	0	0	0.83	1.00
506	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(4), GAPDH(1), INSR(5), ITCH(1), MAGI1(2), MAGI2(4), RERE(5), WWP2(2)	9532109	26	17	26	13	9	6	2	6	3	0	0.83	1.00
507	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA1(1), ACADM(2), ACADS(4), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	17450125	52	27	50	14	20	7	10	7	8	0	0.83	1.00
508	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), SNCAIP(2), UBE2E2(2), UBE2L3(1)	2567484	8	4	8	2	2	0	2	2	2	0	0.84	1.00
509	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), MAP2K3(1), MAPK14(1), NFATC1(3), NFATC2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	4513284	12	8	12	9	2	0	1	5	4	0	0.84	1.00
510	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1), OXCT1(1)	1377947	2	2	2	0	0	0	1	1	0	0	0.84	1.00
511	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(3), OAT(1), PRODH(1)	2059879	6	3	6	1	2	0	1	1	2	0	0.84	1.00
512	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTAP(1), MTFMT(1), MTR(2), TAT(3)	8300658	28	16	28	9	11	9	2	3	3	0	0.84	1.00
513	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2D(1), CAMK2G(4), DAG1(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFAT5(3), PDE6A(4), PDE6B(7), PDE6C(1), PDE6D(1), SLC6A13(2)	14093721	57	25	56	15	20	9	11	9	8	0	0.85	1.00
514	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(2), GFPT1(5), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), PGM3(2), UAP1(1)	6734770	23	12	22	3	10	2	4	4	3	0	0.85	1.00
515	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(5), ATP4A(5), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA3(1), NDUFA4(2), NDUFA4L2(1), NDUFA8(1), NDUFB1(1), NDUFB7(1), NDUFS2(1), NDUFS4(1), NDUFS7(1), NDUFV1(2), NDUFV2(2), PPA1(1), PPA2(1), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRQ(2)	22312708	77	37	77	25	23	16	20	10	8	0	0.85	1.00
516	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(3), ASH2L(1), CARM1(1), CTCFL(3), EED(2), EHMT1(3), EHMT2(2), EZH1(2), EZH2(2), FBXO11(3), HCFC1(3), HSF4(1), JMJD4(2), KDM6A(2), MEN1(2), MLL(3), MLL2(7), MLL3(12), MLL4(7), MLL5(3), NSD1(7), OGT(3), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(8), PRMT6(5), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(9), SETD7(2), SETD8(1), SETDB2(3), SMYD3(1), SUV39H2(3), SUV420H1(1), SUV420H2(3), SUZ12(1), WHSC1(4), WHSC1L1(7)	46933904	134	64	129	39	27	21	38	23	25	0	0.86	1.00
517	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(1), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), F2(1), GNA11(2), GNB1(1), GNGT1(1), JAK2(4), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK14(1), MAPK3(2), MAPT(1), MYLK(7), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), SYT1(1)	16725683	50	29	49	20	15	6	11	14	4	0	0.86	1.00
518	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT2(1), FUT8(1), ST3GAL1(2), ST3GAL3(1)	3137179	7	5	7	1	2	2	2	0	1	0	0.86	1.00
519	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), CAPN1(5), CAPN10(2), CAPN11(1), CAPN2(1), CAPN3(2), CAPN5(1), CAPN6(5), CAPNS1(1), CAV1(1), CAV3(1), DOCK1(9), GIT2(2), ILK(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK6(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PIK3R2(5), PTK2(2), PXN(1), RAP1B(2), RHO(1), ROCK1(3), ROCK2(4), SEPP1(1), SHC3(1), SORBS1(2), SOS1(1), SRC(2), TLN1(6), TNS1(5), VASP(2), VAV2(3), VAV3(2), VCL(2), ZYX(2)	52505328	182	77	181	71	69	23	38	27	25	0	0.86	1.00
520	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(1), BIRC3(1), MAP3K3(4), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), RALBP1(3), RIPK1(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	10653196	33	17	33	16	10	5	5	8	5	0	0.86	1.00
521	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(1), UQCRC1(3)	2672895	4	4	4	4	0	2	0	1	1	0	0.86	1.00
522	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(1), AKT3(1), ARHGEF11(3), BCL2(3), DLG4(2), LPA(6), MAP3K1(5), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PHKA2(4), PIK3CB(2), PLD2(1), PTK2(2), ROCK1(3), ROCK2(4), SRF(2)	19326712	54	30	54	20	16	11	10	7	10	0	0.86	1.00
523	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(1), EPO(1), EPOR(1), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PLCG1(3), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2)	8596885	26	15	25	7	13	2	6	3	2	0	0.87	1.00
524	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), GCK(2), GMDS(1), GMPPA(1), HK2(3), HK3(4), MPI(1), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1)	9558665	39	18	38	5	17	5	7	9	1	0	0.88	1.00
525	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF1D(4), EEF2(4), EEF2K(2), EIF2AK1(2), EIF2AK2(1), EIF2AK3(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G3(1), EIF5A(1), EIF5B(3), ETF1(1), GSPT2(1), KIAA0664(4), PABPC3(2)	17275881	45	23	43	13	10	5	7	17	6	0	0.88	1.00
526	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST12(1), CHST13(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4)	3705994	11	6	11	5	4	1	2	3	1	0	0.88	1.00
527	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(6), NCOA1(3), NCOA2(1), RXRA(3)	7314514	21	10	21	5	3	4	7	2	3	2	0.89	1.00
528	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT5(2), FUT6(2), ST3GAL3(1)	1913974	8	3	8	5	5	1	1	1	0	0	0.89	1.00
529	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), FTCD(3), GART(3), MTFMT(1), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1)	7607519	21	12	21	9	5	4	5	3	4	0	0.89	1.00
530	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(2), DOLPP1(1), DPAGT1(1), FUT8(1), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), RFT1(1), RPN1(1), ST6GAL1(4)	16795454	44	24	44	15	13	7	8	10	6	0	0.89	1.00
531	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(8), MPI(1), PYGL(1), PYGM(2), TREH(2)	5368237	14	8	14	9	8	1	2	2	1	0	0.89	1.00
532	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BCL2(3), BID(4), BIRC2(1), BIRC3(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GAS2(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(2), TNFRSF25(1), TNFSF10(5), TRAF2(2)	13385023	42	21	38	13	8	1	14	15	4	0	0.89	1.00
533	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), BTRC(1), CDC20(2), CDC23(1), CDC27(3), CUL1(5), CUL2(4), CUL3(1), FBXW11(2), FBXW7(2), ITCH(1), SMURF1(6), TCEB2(1), UBE2E2(2), VHL(1), WWP2(2)	16014634	46	23	46	10	11	4	9	12	10	0	0.90	1.00
534	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(2), OPRK1(1), POLR2A(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5009356	9	7	9	3	4	1	1	2	1	0	0.90	1.00
535	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(7), ASAH1(1), CAV3(1), DAG1(2), DLG4(2), EPHB2(6), GNAQ(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), RHO(1), RYR1(14)	18204668	74	32	74	23	30	13	13	13	5	0	0.90	1.00
536	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2)	1481400	2	2	2	4	2	0	0	0	0	0	0.91	1.00
537	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(7), AXIN1(2), BTRC(1), FZD1(1), GSK3B(1), NOTCH1(4)	7699463	16	11	14	8	3	0	4	8	1	0	0.91	1.00
538	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(3)	3347164	11	4	11	5	2	1	2	3	1	2	0.91	1.00
539	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(1), RANGAP1(1)	3294692	3	3	3	2	1	0	1	1	0	0	0.91	1.00
540	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), PER1(3)	3359241	10	5	10	4	2	1	3	1	3	0	0.91	1.00
541	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT2(1), B3GALT5(2), B3GNT5(1), FUT1(1), ST3GAL3(1)	2868757	8	4	8	6	4	1	2	1	0	0	0.91	1.00
542	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG8(1), ALG9(1), B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), B4GALT7(1), C1GALT1C1(3), CHST1(2), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST2(3), CHST3(1), CHST6(1), CHST7(2), CHSY1(1), DDOST(2), DPAGT1(1), EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), FUT8(1), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), NDST1(2), NDST2(2), NDST3(2), NDST4(5), OGT(3), RPN1(1), ST3GAL1(2), ST3GAL3(1), ST6GAL1(4), ST6GALNAC1(2), UST(2), WBSCR17(7), XYLT1(3), XYLT2(1)	43749781	164	66	164	50	60	23	32	24	25	0	0.91	1.00
543	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS7(1), LCMT1(1), PRMT6(5), PRMT7(2), PRMT8(1)	5679684	11	9	7	7	3	0	7	1	0	0	0.92	1.00
544	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1B10(2), AKR1C4(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), RDH13(1), SOAT1(2), SOAT2(2)	12781541	37	20	37	9	17	7	8	5	0	0	0.92	1.00
545	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(3), CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ENTPD3(1), ITPA(1), NME7(3), NT5C1B(3), NT5C2(2), NUDT2(1), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), PRIM2(5), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), TXNRD2(3), UPB1(1), UPP1(2), UPP2(1), ZNRD1(1)	32471747	94	48	90	37	28	12	26	11	17	0	0.92	1.00
546	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC3(1), PSMD14(1), RPN1(1), UBE2A(1), UBE3A(5)	5186159	15	6	15	3	1	2	3	5	2	2	0.92	1.00
547	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(3), GSK3B(1)	4666550	8	5	8	2	1	1	1	2	3	0	0.92	1.00
548	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(2), DHRS7(1), PON1(4), PON3(2), RDH13(1)	3385089	10	5	10	3	4	1	3	2	0	0	0.93	1.00
549	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(2)	2548853	6	3	6	1	0	2	1	3	0	0	0.93	1.00
550	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(1), B4GALT7(1), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST3(1), CHST7(2), CHSY1(1), UST(2), XYLT1(3), XYLT2(1)	5485838	17	10	17	6	7	1	5	1	3	0	0.93	1.00
551	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(4), GLB1(1), HEXA(1), LCT(8), ST3GAL1(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1)	6634452	23	11	23	9	13	1	4	3	2	0	0.93	1.00
552	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(1), PRKCA(3), PTPRA(4), SRC(2)	3687886	10	5	10	2	4	1	2	1	2	0	0.93	1.00
553	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2), RDH13(1)	1922363	5	3	5	0	4	0	1	0	0	0	0.93	1.00
554	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(6), CHUK(4), DAXX(4), ELK1(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(1), NFKBIA(2), PAK1(2), RIPK1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SP1(6), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2)	37712148	113	54	108	39	32	13	15	31	22	0	0.93	1.00
555	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(1), MAT1A(2), PAPSS2(1), SCLY(1), SEPHS1(1)	4922070	11	7	11	7	5	2	2	2	0	0	0.94	1.00
556	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(4), BTK(1), EEA1(2), GRASP(2), GSK3B(1), LYN(1), PFKM(3), PFKP(6), PLCG1(3), PRKCE(1), PRKCZ(2), RPS6KB1(1), VAV2(3)	9711807	33	15	33	11	9	8	4	5	7	0	0.94	1.00
557	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(1), FOS(1), IL2(1), IL2RA(3), IL2RB(1), JAK1(3), JAK3(4), MAP2K1(1), MAPK3(2), SOS1(1), STAT5A(2), STAT5B(2), SYK(2)	9381702	27	14	26	12	9	2	7	6	3	0	0.94	1.00
558	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(1), SOS1(1), SRC(2)	3530468	4	4	4	4	1	1	1	1	0	0	0.94	1.00
559	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(3)	6221687	17	8	17	9	3	3	3	4	2	2	0.94	1.00
560	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(3), PGAP1(3), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2)	9471806	30	14	30	4	8	4	10	4	2	2	0.94	1.00
561	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(1), CBX3(1), CLDN5(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), EIF4G2(2), GFRA1(1), GSTM3(1), GSTP1(1), HERPUD1(1), KLF9(1), NCKAP1(2), NCOA4(3), PER1(3), PER2(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(2), TUBB3(1), UCP3(2), UGP2(1), ZFR(1)	14458089	39	20	38	11	10	2	12	8	7	0	0.94	1.00
562	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(4)	2874536	9	3	9	7	2	1	1	3	0	2	0.95	1.00
563	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(7), AXIN1(2), CREBBP(8), EP300(6), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), TRRAP(8)	12947179	36	20	36	17	10	4	13	4	3	2	0.95	1.00
564	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), GNB1(1), GNGT1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3)	3641689	11	5	11	8	4	0	3	4	0	0	0.95	1.00
565	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(1), ALDOC(3)	1572725	7	2	7	1	3	2	1	1	0	0	0.95	1.00
566	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GGT1(2), SHMT2(1)	2166090	4	3	4	1	2	0	1	0	1	0	0.95	1.00
567	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMB8(1)	3478665	7	4	7	1	1	1	1	3	1	0	0.95	1.00
568	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2)	1933650	6	2	6	4	4	0	1	0	1	0	0.95	1.00
569	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1)	6826923	11	8	11	7	2	2	2	3	2	0	0.95	1.00
570	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PHKA2(4), PIK3CB(2), PLD2(1), VN1R1(1)	17422545	60	26	60	15	18	11	9	10	12	0	0.95	1.00
571	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(1)	2926677	6	4	6	3	2	0	2	1	1	0	0.96	1.00
572	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(3), FOS(1), HDAC2(3), HDAC5(4), NCOR2(5), RBL1(3), RBL2(1), SIN3A(2), SIN3B(6)	10170982	28	14	28	7	9	4	8	3	4	0	0.96	1.00
573	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(2), LCMT1(1), MARS(1), MAT1A(2), PAPSS2(1), PRMT6(5), PRMT7(2), PRMT8(1), SCLY(1), SEPHS1(1)	9855100	21	15	17	12	8	2	8	3	0	0	0.96	1.00
574	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1)	5295093	9	7	9	4	4	0	3	1	1	0	0.96	1.00
575	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CYP2C9(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2)	12265492	30	18	30	10	7	5	6	6	6	0	0.96	1.00
576	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1)	6163897	14	8	14	7	3	2	2	4	3	0	0.96	1.00
577	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	FOS(1), MAPK1(3), MAPK14(1), NFE2L2(1), PRKCA(3)	3445740	9	4	9	4	2	2	1	4	0	0	0.96	1.00
578	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), FUK(1), GMDS(1), GMPPA(1), HK2(3), HK3(4), LHPP(1), MPI(1), MTMR1(2), MTMR2(3), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PGM2(2), PMM1(1), RDH13(1)	14689970	50	23	49	6	21	6	10	10	3	0	0.97	1.00
579	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), GART(3), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1)	7282297	17	10	17	9	4	4	5	1	3	0	0.97	1.00
580	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), AK1(1), ALLC(3), AMPD1(7), AMPD3(4), APRT(3), ATIC(1), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NPR1(6), NPR2(1), NUDT2(1), PAPSS2(1), PDE1A(1), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6B(7), PDE6C(1), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(5), PKLR(4), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2)	51133096	153	70	144	55	59	14	32	24	22	2	0.97	1.00
581	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), NPAS2(1), NR1D1(3), PER1(3), PER2(2), PER3(1)	6718626	17	10	16	8	5	2	3	4	3	0	0.97	1.00
582	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT2(1)	1612285	3	2	3	0	2	0	1	0	0	0	0.97	1.00
583	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTR(2)	7027617	22	11	22	9	9	6	2	3	2	0	0.97	1.00
584	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2(3), BCL2A1(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CRADD(1), DAXX(4), DFFA(1), DFFB(3), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(4), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3)	17487405	45	25	45	16	10	7	12	11	5	0	0.97	1.00
585	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2)	6448451	14	8	14	4	2	2	3	3	4	0	0.97	1.00
586	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2)	2219692	2	2	2	1	1	0	1	0	0	0	0.97	1.00
587	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), FN3K(1), HADHA(1), ITGB1BP3(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2)	10227781	23	13	23	7	4	5	3	5	6	0	0.98	1.00
588	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADSSL1(1), AK1(1), AK7(2), ALLC(3), AMPD1(7), AMPD3(4), APRT(3), ATIC(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), ENTPD3(1), GART(3), GMPR(1), GMPR2(1), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NME7(3), NPR1(6), NPR2(1), NT5C1B(3), NT5C2(2), NUDT2(1), PAPSS2(1), PDE11A(2), PDE1A(1), PDE1C(4), PDE2A(3), PDE3B(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6D(1), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), PRIM2(5), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(1), RRM1(2), XDH(8), ZNRD1(1)	65586450	204	83	193	70	71	28	43	27	35	0	0.98	1.00
589	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), MAP2(3), PPP2CA(1), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1), PRKCE(1)	7405607	14	8	14	9	2	5	2	3	2	0	0.98	1.00
590	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHFR(1), DHX58(2), EP400(15), ERCC2(1), ERCC3(2), FPGS(2), IFIH1(2), MOV10L1(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SKIV2L2(1), SMARCA2(5), SMARCA5(2)	24991247	79	37	79	26	25	13	18	14	9	0	0.98	1.00
591	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB3(1), CREB5(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(1), IL1R1(2), MAP2K3(1), MAP3K10(3), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), NFKB1(1), SRF(2)	13300265	30	18	30	9	10	4	1	11	4	0	0.98	1.00
592	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), GPI(4), PKLR(4)	3384490	9	4	9	2	5	0	1	1	2	0	0.98	1.00
593	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), WASF1(1)	3282209	7	3	7	1	1	1	1	1	3	0	0.98	1.00
594	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(3), APC(7), ATF2(1), AXIN1(2), BMP10(2), BMP5(3), BMPR1A(2), BMPR2(2), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(2), MEF2C(1), MYL2(2), RFC1(3), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2)	14155219	44	18	44	13	9	6	13	10	6	0	0.98	1.00
595	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ITPA(1), NUDT2(1), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), RRM1(2), TK2(1), TXNRD1(1), UPB1(1), UPP1(2)	22781723	59	30	58	26	15	9	19	7	7	2	0.98	1.00
596	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	35	CCNH(2), ERCC3(2), GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(2), POLR1A(3), POLR1B(1), POLR2A(2), POLR2B(4), POLR3B(4), POLR3D(1), TAF5(2), TAF6(3), TAF7(2), TAF9(1), TBP(2)	14056316	36	17	35	6	7	5	13	5	6	0	0.98	1.00
597	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS2(3), EARS2(2), EPRS(2), FARSA(1), FARSB(1), HARS(3), HARS2(1), IARS(4), IARS2(1), KARS(4), LARS(3), LARS2(1), MARS(1), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(1), VARS(3), VARS2(5), YARS(2), YARS2(2)	21945440	59	29	58	22	16	9	13	13	8	0	0.99	1.00
598	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), ARPC4(1), DIAPH1(2), GSN(2), LIMK1(1), MYL2(2), MYLK(7), OPHN1(1), PIP5K1B(2), PPP1R12B(6), ROCK1(3), SRC(2), TLN1(6), VCL(2)	18138147	52	23	52	15	21	7	8	6	10	0	0.99	1.00
599	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), ZNRD1(1)	9520788	23	12	23	3	8	4	5	3	3	0	0.99	1.00
600	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25B(1), SHH(2), XPO1(2)	3517835	7	3	7	0	0	2	3	2	0	0	0.99	1.00
601	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1), PDK3(1), PDK4(2), PDP2(1), SUCLA2(1), SUCLG1(2)	11406070	26	14	26	17	7	6	7	4	2	0	0.99	1.00
602	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	1626459	1	1	1	0	0	0	0	1	0	0	0.99	1.00
603	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), NRG2(1), NRG3(1), PRKCA(3)	3608656	6	3	6	4	3	0	1	1	1	0	0.99	1.00
604	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN3(1), CAPN1(5), CAPNS1(1), ITGA1(1), ITGB3(1), PTK2(2), PXN(1), SPTAN1(6), SRC(2), TLN1(6)	11191079	28	13	28	10	13	2	4	7	2	0	0.99	1.00
605	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN3(1), BCR(1), CAPN1(5), CAPNS1(1), CAV1(1), ITGA1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), PPP1R12B(6), PTK2(2), PXN(1), ROCK1(3), SOS1(1), SRC(2), TLN1(6), VCL(2), ZYX(2)	18381154	44	22	44	14	16	6	6	11	5	0	0.99	1.00
606	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN3(1), CTNNA1(1), CTNNA2(2), PECAM1(2), PTK2(2), PXN(1), SRC(2), VCL(2)	7930015	14	9	14	6	5	2	3	2	2	0	1.00	1.00
607	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC2(1), PSMC3(1), PSMD11(1), PSMD12(3)	6453136	12	5	12	3	1	1	2	4	4	0	1.00	1.00
608	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1)	1723510	2	1	2	0	1	0	0	1	0	0	1.00	1.00
609	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(2), GBF1(5), GPLD1(3), KDELR1(1), KDELR2(1)	6465040	16	6	16	6	5	2	3	4	0	2	1.00	1.00
610	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), EPRS(2), HARS(3), IARS(4), KARS(4), LARS(3), LARS2(1), MARS(1), NARS(1), QARS(3), TARS(2), YARS(2)	13075913	29	14	29	11	8	6	5	5	5	0	1.00	1.00
611	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), IDH2(2), OGDH(1), SUCLA2(1)	3806392	5	3	5	9	2	1	2	0	0	0	1.00	1.00
612	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), DRD1(2), DRD2(1), GRM1(1), PLCB1(4), PPP2CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6247312	13	5	13	11	4	2	1	3	1	2	1.00	1.00
613	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), PLOD1(2), PLOD3(1), SDS(4), SHMT2(1), TMLHE(1)	14665322	40	17	40	9	7	12	9	6	6	0	1.00	1.00
614	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), AKAP10(4), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(2), AKAP5(2), AKAP6(5), AKAP7(1), AKAP8(3), AKAP9(4), ARHGEF1(2), CALM1(1), GNA11(2), GNA12(2), GNA15(4), GNAI2(1), GNAL(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNGT1(1), GNGT2(1), ITPR1(7), KCNJ3(2), KRAS(1), NRAS(1), PDE1A(1), PDE1C(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PLCB3(5), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), PRKD3(6), RHOA(1), SLC9A1(3), USP5(5)	46657373	152	58	151	47	51	24	33	24	20	0	1.00	1.00
615	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), HSD17B10(1), HSD17B4(1), NSD1(7), OGDH(1), OGDHL(5), PIPOX(2), PLOD1(2), PLOD3(1), RDH13(1), SETD1A(1), SETD7(2), SHMT2(1), SUV39H2(3), TMLHE(1)	23173273	53	23	53	14	17	8	14	8	6	0	1.00	1.00
616	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CLK2(2), CLK4(2), COL2A1(2), CPSF1(4), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDIT3(1), DHX15(1), DHX16(4), DHX38(4), DHX8(4), DHX9(2), DICER1(4), FUS(1), GIPC1(2), NCBP2(1), NONO(3), NUDT21(2), NXF1(1), PABPN1(2), PHF5A(1), POLR2A(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(9), PSKH1(1), PTBP1(2), PTBP2(1), RBM17(1), RNGTT(1), SF3A1(2), SF3A3(2), SF3B1(2), SF3B2(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SRPK1(2), SRPK2(3), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF2(2), XRN2(2)	41964994	94	40	94	19	28	9	22	14	21	0	1.00	1.00
