Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.132 0.271 -9999.0 0.0 -0.57 36.0 36.0 IHH -0.011 0.089 -9999.0 0.0 -0.276 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.046 0.139 -9999.0 0.0 -0.314 27.0 27.0 LRPAP1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.046 0.138 0.312 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.116 0.227 -9999.0 0.0 -0.392 45.0 45.0 SMO -0.131 0.23 -9999.0 0.0 -0.399 49.0 49.0 AKT1 -0.086 0.195 -9999.0 0.0 -0.637 12.0 12.0 ARRB2 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.226 -9999.0 0.0 -0.393 49.0 49.0 STIL -0.074 0.144 -9999.0 0.0 -0.277 41.0 41.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.053 0.145 -9999.0 0.0 -0.288 36.0 36.0 PIK3CA 0.011 0.048 -9999.0 0.0 -0.518 1.0 1.0 DHH 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.25 0.45 -9999.0 0.0 -0.987 36.0 36.0 determination of left/right symmetry -0.129 0.226 -9999.0 0.0 -0.393 49.0 49.0 PIK3R1 0.004 0.097 -9999.0 0.0 -0.518 4.0 4.0 skeletal system development -0.246 0.443 -9999.0 0.0 -0.972 36.0 36.0 IHH N/Hhip -0.059 0.163 -9999.0 0.0 -0.428 20.0 20.0 DHH N/Hhip -0.031 0.145 -9999.0 0.0 -0.378 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.226 -9999.0 0.0 -0.393 49.0 49.0 pancreas development -0.065 0.187 -9999.0 0.0 -0.517 19.0 19.0 HHAT -0.003 0.137 -9999.0 0.0 -0.518 9.0 9.0 PI3K 0.005 0.067 -9999.0 0.0 -0.378 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.058 0.189 -9999.0 0.0 -0.518 19.0 19.0 somite specification -0.129 0.226 -9999.0 0.0 -0.393 49.0 49.0 SHH Np/Cholesterol/PTCH1 -0.073 0.151 -9999.0 0.0 -0.287 41.0 41.0 SHH Np/Cholesterol/PTCH2 0.008 0.085 -9999.0 0.0 -0.294 10.0 10.0 SHH Np/Cholesterol/Megalin 0.001 0.092 -9999.0 0.0 -0.303 11.0 11.0 SHH -0.013 0.103 -9999.0 0.0 -0.379 10.0 10.0 catabolic process -0.075 0.152 -9999.0 0.0 -0.323 36.0 36.0 SMO/Vitamin D3 -0.108 0.19 -9999.0 0.0 -0.36 41.0 41.0 SHH Np/Cholesterol/Hhip -0.048 0.137 -9999.0 0.0 -0.315 26.0 26.0 LRP2 0.019 0.056 -9999.0 0.0 -0.518 1.0 1.0 receptor-mediated endocytosis -0.104 0.183 -9999.0 0.0 -0.36 38.0 38.0 SHH Np/Cholesterol/BOC -0.001 0.085 -9999.0 0.0 -0.294 10.0 10.0 SHH Np/Cholesterol/CDO 0.006 0.086 -9999.0 0.0 -0.296 10.0 10.0 mesenchymal cell differentiation 0.047 0.136 0.313 26.0 -9999.0 0.0 26.0 mol:Vitamin D3 -0.073 0.151 -9999.0 0.0 -0.287 41.0 41.0 IHH N/PTCH2 0.018 0.06 -9999.0 0.0 -0.334 1.0 1.0 CDON 0.028 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.06 0.162 -9999.0 0.0 -0.325 36.0 36.0 Megalin/LRPAP1 0.032 0.047 -9999.0 0.0 -0.378 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.081 -9999.0 0.0 -0.292 10.0 10.0 PTCH1 -0.075 0.152 -9999.0 0.0 -0.324 36.0 36.0 HHIP -0.065 0.187 -9999.0 0.0 -0.518 19.0 19.0