rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	222	ADORA1(4), ADORA2A(6), ADORA2B(1), ADRA1A(2), ADRA1B(4), ADRA2B(4), ADRA2C(2), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(3), BDKRB2(1), C3AR1(1), C5AR1(1), CALCR(6), CALCRL(4), CCKAR(2), CCKBR(1), CHRM2(6), CHRM3(5), CHRM4(1), CHRM5(2), CNR1(3), CNR2(3), CRHR1(4), CRHR2(3), CTSG(4), CYSLTR1(3), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(2), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(2), FPR1(1), FSHB(1), GABBR1(3), GABBR2(3), GABRA1(6), GABRA3(5), GABRA4(3), GABRA5(4), GABRB1(3), GABRB2(6), GABRD(2), GABRE(4), GABRG2(5), GABRP(2), GABRQ(6), GABRR1(2), GABRR2(2), GALR1(3), GH1(1), GH2(2), GHR(2), GHRHR(3), GHSR(3), GLP1R(1), GLP2R(4), GLRA1(2), GLRA2(5), GLRA3(3), GLRB(3), GPR156(2), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(6), GRIA2(3), GRIA3(9), GRIA4(7), GRID2(12), GRIK1(4), GRIK2(8), GRIK3(7), GRIK4(4), GRIK5(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(3), GRIN3A(8), GRIN3B(4), GRM2(3), GRM4(1), GRM6(4), GRM7(8), GRM8(9), GRPR(2), GZMA(4), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HRH4(3), HTR1B(3), HTR1D(1), HTR1E(5), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LEPR(10), LHB(1), LHCGR(8), LTB4R2(1), MAS1(3), MC2R(2), MC3R(3), MC4R(1), MC5R(3), MCHR1(2), MCHR2(3), MTNR1A(1), NMBR(2), NMUR2(2), NPBWR1(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(2), OPRK1(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX3(5), P2RX4(2), P2RX7(1), P2RY1(1), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(2), P2RY4(1), P2RY6(2), PARD3(5), PPYR1(3), PRL(1), PRLHR(1), PRLR(5), PRSS1(3), PRSS3(1), PTAFR(3), PTGDR(5), PTGER2(1), PTGER3(5), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(5), RXFP1(7), RXFP2(1), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SSTR5(1), TAAR1(4), TAAR2(2), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(2), TACR1(2), TACR3(3), TBXA2R(2), THRA(2), THRB(1), TRHR(1), TRPV1(2), TSHR(1)	55037422	557	157	554	207	157	205	106	28	61	0	2.71e-07	0.00017
2	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(4), ADORA2A(6), ADORA2B(1), ADRA1A(2), ADRA1B(4), ADRA1D(2), ADRA2C(2), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(3), BDKRB2(1), C3AR1(1), CCBP2(4), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(3), CCRL1(3), CCRL2(1), CHML(1), CHRM2(6), CHRM3(5), CHRM4(1), CHRM5(2), CMKLR1(1), CNR1(3), CNR2(3), CX3CR1(3), CXCR3(1), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(2), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(2), FPR1(1), GALR1(3), GALT(1), GHSR(3), GPR17(5), GPR174(4), GPR27(1), GPR35(1), GPR37(2), GPR37L1(2), GPR50(4), GPR6(2), GPR63(2), GPR77(4), GPR83(2), GPR85(2), GPR87(6), GRPR(2), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HTR1B(3), HTR1D(1), HTR1E(5), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LHCGR(8), MAS1(3), MC3R(3), MC4R(1), MC5R(3), MTNR1A(1), NMBR(2), NMUR2(2), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPN1SW(1), OPN3(1), OPRD1(2), OPRK1(1), OPRM1(2), OR10A5(2), OR11A1(4), OR12D3(4), OR1F1(1), OR1Q1(3), OR2H1(1), OR5V1(1), OR7A5(1), OR8B8(5), OXTR(1), P2RY1(1), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(2), P2RY6(2), PPYR1(3), PTAFR(3), PTGDR(5), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), RGR(2), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(1)	31942456	308	137	307	112	86	113	58	14	37	0	0.000019	0.0059
3	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(5)	2150774	28	26	27	3	5	12	4	5	2	0	0.00060	0.091
4	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(5)	2150774	28	26	27	3	5	12	4	5	2	0	0.00060	0.091
5	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(4), F12(1), F13B(7), F5(15), F8(10), F9(4), FGA(5), FGB(3), FGG(1), LPA(11), PLAT(1), PLAU(2), PLG(2), SERPINB2(3), SERPINE1(2), SERPINF2(3), VWF(16)	9480458	93	69	92	24	19	37	23	6	8	0	0.00074	0.091
6	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA1(6), GABRA3(5), GABRA4(3), GABRA5(4), PRKCE(5)	1635108	23	23	23	5	9	10	3	0	1	0	0.0012	0.12
7	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	130	ACTB(1), COL11A2(10), COL17A1(4), COL1A1(8), COL1A2(15), COL2A1(8), COL3A1(10), COL4A1(11), COL4A2(9), COL4A4(9), COL4A6(9), COL5A1(5), COL5A2(12), COL5A3(11), COL6A3(12), COMP(2), DES(2), DSC1(4), DSC2(1), DSC3(7), DSG1(8), DSG2(2), DSG3(2), DSG4(5), FN1(17), GJA1(4), GJA10(5), GJA8(2), GJB2(1), GJB4(1), GJB5(1), GJC1(2), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(4), INA(2), ITGA6(6), ITGB4(9), KRT1(1), KRT10(1), KRT12(3), KRT13(2), KRT14(1), KRT16(3), KRT17(2), KRT18(2), KRT2(4), KRT20(3), KRT23(2), KRT24(4), KRT27(3), KRT28(2), KRT3(2), KRT31(1), KRT32(2), KRT33A(1), KRT35(1), KRT36(3), KRT37(2), KRT4(1), KRT5(1), KRT6A(2), KRT6B(4), KRT6C(2), KRT71(2), KRT72(2), KRT73(7), KRT74(1), KRT75(2), KRT76(2), KRT77(3), KRT78(1), KRT79(4), KRT81(3), KRT82(1), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(1), LAMA1(14), LAMA2(17), LAMA3(7), LAMA4(15), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(4), LAMC3(1), NES(11), PRPH(2), RELN(26), THBS1(1), THBS3(4), TNC(16), TNXB(16), VIM(5), VWF(16)	63492600	499	148	498	162	140	188	92	32	47	0	0.0028	0.24
8	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(3), AGT(1), AGTR1(3), AGTR2(4), ANPEP(5), CMA1(4), CPA3(4), CTSA(2), CTSG(4), ENPEP(7), LNPEP(2), MAS1(3), MME(6), NLN(2), THOP1(1)	5741924	55	46	55	22	11	23	8	4	9	0	0.0037	0.28
9	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(6), CYP17A1(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(5)	1860812	23	21	22	5	3	11	4	4	1	0	0.0060	0.39
10	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(5), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(2), ARPC1B(1), BCAR1(5), BDKRB1(3), BDKRB2(1), BRAF(7), CD14(1), CDC42(1), CFL1(3), CFL2(1), CHRM2(6), CHRM3(5), CHRM4(1), CHRM5(2), CRKL(1), CYFIP1(6), CYFIP2(7), DIAPH1(1), DIAPH3(5), DOCK1(3), EGF(6), EGFR(9), EZR(1), F2R(2), FGD1(3), FGD3(3), FGF10(2), FGF12(2), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(3), FGFR2(6), FGFR3(2), FGFR4(1), FN1(17), GIT1(1), GNA12(1), GNA13(1), GNG12(1), GRLF1(11), GSN(2), HRAS(2), IQGAP1(6), IQGAP2(6), IQGAP3(11), ITGA1(4), ITGA10(6), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGA7(3), ITGA8(9), ITGA9(1), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(4), ITGB2(3), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(2), ITGB7(1), ITGB8(3), KRAS(1), LIMK1(1), LIMK2(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), MOS(4), MRAS(3), MSN(3), MYH10(3), MYH14(4), MYH9(14), MYL2(1), MYLK(7), MYLK2(2), MYLPF(1), NCKAP1(5), NCKAP1L(9), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PDGFB(1), PDGFRA(8), PDGFRB(5), PFN3(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12B(3), PTK2(3), PXN(3), RAC1(2), RAF1(1), RDX(1), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(6), SOS2(4), SSH1(1), SSH2(7), TIAM1(9), TIAM2(4), VAV1(7), VAV2(4), VAV3(1), VCL(2), WAS(5), WASL(2)	75493894	527	153	523	165	122	198	93	47	67	0	0.0064	0.39
11	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(3), AGTR2(4), CMA1(4), COL4A1(11), COL4A2(9), COL4A3(5), COL4A4(9), COL4A5(3), COL4A6(9)	6924734	61	52	61	22	15	31	7	0	8	0	0.0071	0.40
12	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(8), ADCY8(13), ARAF(3), ATF4(1), BRAF(7), CACNA1C(16), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(12), EP300(5), GRIA1(6), GRIA2(3), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(3), HRAS(2), ITPR1(5), ITPR2(11), ITPR3(3), KRAS(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3)	25589102	196	113	195	65	62	64	31	20	19	0	0.0084	0.43
13	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(3), ACVR1C(3), AKT1(1), AKT3(2), ARRB1(3), ATF2(2), ATF4(1), BDNF(1), BRAF(7), CACNA1A(8), CACNA1B(1), CACNA1C(16), CACNA1D(3), CACNA1E(16), CACNA1F(8), CACNA1G(6), CACNA1H(5), CACNA1I(9), CACNA1S(8), CACNA2D1(8), CACNA2D2(5), CACNA2D3(2), CACNA2D4(5), CACNB1(1), CACNB2(2), CACNB3(2), CACNB4(3), CACNG3(2), CACNG4(2), CACNG6(1), CACNG7(4), CD14(1), CDC25B(3), CDC42(1), CHP(2), CHUK(2), CRKL(1), DAXX(3), DUSP10(3), DUSP16(2), DUSP4(1), DUSP5(4), DUSP6(1), DUSP7(1), DUSP9(4), EGF(6), EGFR(9), FAS(1), FASLG(1), FGF10(2), FGF12(2), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(3), FGFR2(6), FGFR3(2), FGFR4(1), FLNA(9), FLNB(4), FLNC(13), FOS(1), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(2), IKBKB(3), IL1B(1), IL1R2(3), JUN(2), KRAS(1), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K5(2), MAP2K6(3), MAP3K1(3), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(3), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(6), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1), MAPKAPK2(1), MAPKAPK5(4), MAPT(5), MEF2C(2), MOS(4), MRAS(3), MYC(1), NFATC2(5), NFATC4(2), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NTF3(3), NTRK1(3), NTRK2(1), PAK1(3), PAK2(1), PDGFB(1), PDGFRA(8), PDGFRB(5), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PPM1A(2), PPM1B(1), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PPP5C(1), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(1), PTPRR(6), RAC1(2), RAF1(1), RAPGEF2(5), RASA1(6), RASA2(3), RASGRF1(5), RASGRF2(4), RASGRP1(1), RASGRP3(8), RASGRP4(4), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA4(3), RPS6KA5(3), RPS6KA6(3), RRAS2(2), SOS1(6), SOS2(4), SRF(2), STK3(2), STK4(2), TAOK1(6), TAOK2(6), TAOK3(3), TGFB1(1), TGFB2(1), TGFBR2(3), TNFRSF1A(2), TRAF6(1), ZAK(1)	77878204	544	155	539	186	125	215	89	43	72	0	0.010	0.45
14	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(5), AKT1(1), AKT3(2), BCAR1(5), BIRC3(3), BRAF(7), CAPN2(2), CAV2(1), CAV3(1), CCND1(1), CCND2(3), CCND3(1), CDC42(1), COL11A2(10), COL1A1(8), COL1A2(15), COL2A1(8), COL3A1(10), COL4A1(11), COL4A2(9), COL4A4(9), COL4A6(9), COL5A1(5), COL5A2(12), COL5A3(11), COL6A3(12), COMP(2), CRKL(1), CTNNB1(3), DIAPH1(1), DOCK1(3), EGF(6), EGFR(9), ERBB2(3), FARP2(6), FIGF(1), FLNA(9), FLNB(4), FLNC(13), FLT1(9), FN1(17), FYN(4), GRLF1(11), GSK3B(1), HGF(6), HRAS(2), IBSP(4), IGF1(2), IGF1R(1), ILK(1), ITGA1(4), ITGA10(6), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGA7(3), ITGA8(9), ITGA9(1), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(2), ITGB7(1), ITGB8(3), JUN(2), KDR(11), LAMA1(14), LAMA2(17), LAMA3(7), LAMA4(15), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(4), LAMC3(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MET(3), MYL2(1), MYLK(7), MYLK2(2), MYLPF(1), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PARVB(1), PARVG(1), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(5), PDPK1(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRKCA(5), PRKCG(9), PTK2(3), PXN(3), RAC1(2), RAF1(1), RAPGEF1(3), RELN(26), ROCK1(5), ROCK2(3), SHC1(1), SHC2(3), SHC3(3), SHC4(4), SOS1(6), SOS2(4), THBS1(1), THBS3(4), TLN1(8), TLN2(11), TNC(16), TNXB(16), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCL(2), VEGFC(4), VWF(16)	96547022	722	162	718	245	193	273	125	54	77	0	0.010	0.45
15	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(1), AKT3(2), BLNK(1), BTK(5), CARD11(3), CD19(2), CD22(5), CD79A(1), CD81(1), CHP(2), CHUK(2), CR2(9), FCGR2B(2), FOS(1), GSK3B(1), HRAS(2), IKBKB(3), INPP5D(6), JUN(2), KRAS(1), LILRB3(3), LYN(1), MALT1(2), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), RAC1(2), RASGRP3(8), SYK(1), VAV1(7), VAV2(4), VAV3(1)	19679502	138	92	138	46	36	42	18	20	22	0	0.011	0.45
16	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(2), ADRA1B(4), ADRA1D(2), ADRA2C(2), ADRB2(3), CHRM2(6), CHRM3(5), CHRM4(1), CHRM5(2), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(2), HTR1B(3), HTR1D(1), HTR1E(5), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(3)	6776282	71	51	71	28	18	25	20	3	5	0	0.016	0.61
17	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	10	CASR(8), GABBR1(3), GPRC5A(1), GPRC5C(4), GPRC5D(1), GRM2(3), GRM4(1), GRM7(8), GRM8(9)	3921696	38	33	38	22	8	12	8	5	5	0	0.020	0.70
18	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(3), AGTR2(4), ATP8A1(6), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(3), BDKRB2(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(3), CX3CR1(3), CXCR3(1), EDNRA(2), EDNRB(5), FPR1(1), GALR1(3), GALT(1), GHSR(3), GPR77(4), GRPR(2), LHCGR(8), MC2R(2), MC3R(3), MC4R(1), MC5R(3), NMBR(2), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(2), OPRK1(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), TACR1(2), TACR3(3), TRHR(1), TSHR(1)	13275596	118	74	117	50	32	44	18	4	20	0	0.022	0.70
19	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(2)	537204	8	8	8	3	3	1	3	0	1	0	0.023	0.70
20	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(3), NOS1(10), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), SYT1(3)	6076030	57	45	57	20	18	19	5	7	8	0	0.023	0.70
21	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(3), BRAF(7), C7orf16(1), CACNA1A(8), CRHR1(4), GNA12(1), GNA13(1), GNAI1(2), GNAI3(1), GNAS(4), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(9), GRID2(12), GUCY1A3(6), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(8), HRAS(2), IGF1(2), IGF1R(1), ITPR1(5), ITPR2(11), ITPR3(3), KRAS(1), LYN(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), NOS1(10), NOS3(1), NPR1(2), NPR2(5), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PPP2R1A(6), PPP2R1B(2), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(5), RAF1(1), RYR1(29)	28702856	244	113	242	77	63	94	40	17	30	0	0.026	0.70
22	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(4), GNB1(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5)	2534364	23	23	23	8	5	11	3	1	3	0	0.026	0.70
23	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(1), AGTR2(4), EDN1(1), EDNRA(2), EDNRB(5), EGF(6), EGFR(9), FOS(1), HRAS(2), JUN(2), MYC(1), NFKB1(2), PLCG1(2), PRKCA(5), RELA(3)	5560898	51	41	50	15	10	20	7	4	10	0	0.026	0.70
24	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	161	ADCY1(8), ADCY3(5), ADCY4(4), ADCY7(4), ADCY8(13), ADCY9(4), ADORA2A(6), ADORA2B(1), ADRA1A(2), ADRA1B(4), ADRA1D(2), ADRB2(3), AGTR1(3), ATP2A1(2), ATP2A2(6), ATP2A3(2), ATP2B1(4), ATP2B2(6), ATP2B3(3), ATP2B4(5), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(1), BST1(1), CACNA1A(8), CACNA1B(1), CACNA1C(16), CACNA1D(3), CACNA1E(16), CACNA1F(8), CACNA1G(6), CACNA1H(5), CACNA1I(9), CACNA1S(8), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(1), CD38(1), CHP(2), CHRM2(6), CHRM3(5), CHRM5(2), CYSLTR1(3), CYSLTR2(1), DRD1(1), EDNRA(2), EDNRB(5), EGFR(9), ERBB2(3), ERBB3(3), ERBB4(9), F2R(2), GNA14(1), GNA15(1), GNAL(2), GNAS(4), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(3), GRPR(2), HRH1(3), HRH2(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), LHCGR(8), LTB4R2(1), MYLK(7), MYLK2(2), NOS1(10), NOS3(1), NTSR1(3), OXTR(1), P2RX2(1), P2RX3(5), P2RX4(2), P2RX7(1), PDE1A(2), PDE1B(1), PDGFRA(8), PDGFRB(5), PHKA1(4), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLCD3(2), PLCE1(10), PLCG1(2), PLCG2(3), PLCZ1(3), PLN(1), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(2), RYR1(29), SLC8A3(3), SPHK2(1), TACR1(2), TACR3(3), TBXA2R(2), TNNC1(1), TNNC2(1), TRHR(1), TRPC1(5), VDAC1(1), VDAC2(1)	66805002	521	152	519	180	162	185	78	44	52	0	0.027	0.70
25	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(2), AKT1(1), BDKRB2(1), CHRNA1(2), FLT1(9), FLT4(3), KDR(11), NOS3(1), PDE2A(3), PDE3A(5), PDE3B(3), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKG1(5), PRKG2(5), SLC7A1(5), SYT1(3), TNNI1(1)	8525844	70	56	70	35	22	20	9	8	11	0	0.029	0.71
26	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	12	AOX1(11), CD38(1), ENPP1(7), ENPP3(4), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(7), NT5E(2)	3568188	38	32	37	6	13	14	4	4	3	0	0.030	0.71
27	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(1), CD3D(1), CD4(2), CXCR3(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), JAK2(3), STAT4(4), TYK2(8)	3830026	31	30	31	9	7	9	6	2	7	0	0.032	0.71
28	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(3), BID(1), BRAF(7), CD244(1), CHP(2), FAS(1), FASLG(1), FCGR3A(3), FCGR3B(2), FYN(4), GZMB(1), HLA-B(1), HLA-C(1), HLA-G(1), HRAS(2), ICAM1(2), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), ITGAL(1), ITGB2(3), KIR2DL1(3), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(1), KRAS(1), LAT(1), LCK(2), LCP2(2), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), NCR1(5), NCR2(1), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), PAK1(3), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(2), PLCG2(3), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRF1(2), PRKCA(5), PRKCG(9), PTPN11(3), RAC1(2), RAF1(1), SH2D1A(1), SH3BP2(2), SHC1(1), SHC2(3), SHC3(3), SHC4(4), SOS1(6), SOS2(4), SYK(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(1), ULBP3(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(3)	29957578	214	112	214	68	56	77	41	20	20	0	0.033	0.71
29	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(1), CXCR3(1), ETV5(3), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(3), JUN(2), MAP2K6(3), MAPK14(1), MAPK8(2), STAT4(4), TYK2(8)	4886634	41	38	41	10	9	16	7	3	6	0	0.033	0.71
30	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(7), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(4), HSD3B2(5)	2187264	20	20	19	4	6	6	4	3	1	0	0.036	0.71
31	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(9), NRG2(2), NRG3(5), PRKCA(5), PSEN1(1)	2417774	22	22	22	8	3	9	3	2	5	0	0.036	0.71
32	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(11), COL4A2(9), COL4A3(5), COL4A4(9), COL4A5(3), COL4A6(9), F10(3), F11(4), F12(1), F2R(2), F5(15), F8(10), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), SERPINC1(5)	12073384	103	69	103	31	22	47	20	3	11	0	0.039	0.76
33	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(4), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6)	2761848	27	24	27	4	6	7	6	3	5	0	0.044	0.81
34	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(11), BST1(1), CD38(1), ENPP1(7), ENPP3(4), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(4), NT5E(2), NUDT12(2)	5471720	52	42	51	10	17	19	7	4	5	0	0.045	0.81
35	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BUB1(4), CDKL1(1), CDKL2(2), CDS1(2), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(3), MOS(4), NEK1(3), NEK3(1), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(1), PIK3CG(10), PIM2(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLCG1(2), PLCG2(3), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCQ(4), PRKD1(9), PRKG1(5), RAF1(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA4(3), RPS6KB1(1), STK11(3), VRK1(1)	30579510	214	111	213	60	64	74	36	15	25	0	0.048	0.85
36	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(6), GREB1(15), HSPB2(1), MTA1(2), MTA3(3), TUBA8(1)	3050208	30	27	30	10	9	13	6	1	1	0	0.053	0.91
37	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	9	EPX(5), GBA3(6), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TYR(3)	2183170	21	19	21	7	3	6	10	0	2	0	0.055	0.92
38	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNG(1), IFNGR1(3), IFNGR2(1), IKBKB(3), JAK2(3), LIN7A(2), NFKB1(2), RB1(7), RELA(3), TNFRSF1A(2), TNFRSF1B(1), USH1C(5), WT1(4)	4848186	37	33	37	7	6	11	9	3	8	0	0.058	0.94
39	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(4)	435032	6	6	5	1	4	1	1	0	0	0	0.060	0.94
40	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(8), ADRB2(3), GNAS(4), PLCE1(10), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	3962102	35	32	34	11	15	9	5	3	3	0	0.062	0.95
41	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(3), EGF(6), EGFR(9), MET(3), PDGFRA(8), PRKCA(5), SH3GLB1(1), SH3KBP1(7)	5214866	46	39	45	10	11	20	6	3	6	0	0.064	0.96
42	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(9), HRAS(2), ITGA1(4), ITGB1(4), MAPK1(1), MAPK3(2), MYL2(1), MYLK(7), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(8)	8846956	68	55	66	19	17	27	8	7	9	0	0.065	0.96
43	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(1), AKT3(2), BTK(5), FCER1A(1), FYN(4), HRAS(2), IL4(2), INPP5D(6), KRAS(1), LAT(1), LCP2(2), LYN(1), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK8(2), MAPK9(1), MS4A2(2), PDK1(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLCG1(2), PLCG2(3), PRKCA(5), PRKCD(2), PRKCE(5), RAC1(2), RAF1(1), SOS1(6), SOS2(4), SYK(1), VAV1(7), VAV2(4), VAV3(1)	19044220	136	88	136	41	34	48	23	13	18	0	0.069	0.99
44	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(1), GABARAP(1), GABRA1(6), GABRA3(5), GABRA4(3), GABRA5(4), GPHN(1), NSF(2), UBQLN1(2)	2732656	25	24	25	6	7	13	4	0	1	0	0.075	1.00
45	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(1), AKR1D1(4), ARSB(2), ARSD(1), ARSE(2), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(5), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1), UGT2B4(4)	6786072	56	45	55	10	14	18	11	7	6	0	0.076	1.00
46	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(4), GNB1(1), PRKACA(1), PRKAR1A(3)	1804742	17	17	17	5	7	5	3	1	1	0	0.081	1.00
47	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(5), SPCS1(1), SPCS3(2)	845144	9	8	9	2	0	2	2	1	4	0	0.082	1.00
48	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	124	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(5), AKT1(1), AKT3(2), AMOTL1(2), ASH1L(10), CASK(1), CDC42(1), CGN(5), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(2), CLDN9(3), CSDA(2), CSNK2A1(2), CTNNB1(3), CTTN(4), EPB41(2), EPB41L1(4), EPB41L2(1), EXOC3(2), EXOC4(2), F11R(1), GNAI1(2), GNAI3(1), HCLS1(3), HRAS(2), IGSF5(1), INADL(9), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(5), MAGI2(7), MAGI3(2), MLLT4(3), MPDZ(4), MPP5(2), MRAS(3), MYH1(13), MYH10(3), MYH11(8), MYH13(10), MYH14(4), MYH15(11), MYH3(5), MYH4(14), MYH6(12), MYH7(9), MYH7B(4), MYH9(14), MYL2(1), MYLPF(1), PARD3(5), PARD6A(2), PPM1J(1), PPP2R1A(6), PPP2R1B(2), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP2R3A(2), PPP2R4(1), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCI(4), PRKCQ(4), RAB13(1), RAB3B(1), RRAS2(2), SPTAN1(2), SYMPK(6), TJAP1(3), TJP1(9), TJP2(5), TJP3(2), VAPA(1), YES1(1), ZAK(1)	48885030	327	136	327	119	81	114	60	31	41	0	0.083	1.00
49	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(2), ACTN2(6), ACTN3(2), ACTN4(5), DES(2), DMD(20), FAM48A(1), MYBPC1(11), MYBPC3(3), MYH3(5), MYH6(12), MYH7(9), MYL1(4), MYL2(1), MYL3(2), MYOM1(8), NEB(23), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(2), TNNT1(1), TNNT2(2), TNNT3(3), TPM3(2), VIM(5)	16816728	134	82	133	56	42	40	25	10	17	0	0.086	1.00
50	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), DAB1(5), FYN(4), LRP8(1), RELN(26), VLDLR(1)	3755444	39	28	39	11	7	13	10	7	2	0	0.087	1.00
51	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(5), CD2(1), CD33(2), CD5(3), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(3), IL4(2), ITGAX(9), TLR2(3), TLR7(3), TLR9(1)	4550748	37	34	35	13	10	15	5	2	5	0	0.089	1.00
52	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(4), RXRA(1)	1464406	13	13	13	3	4	4	2	1	2	0	0.094	1.00
53	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(6), AASDHPPT(1), AASS(6), KARS(3)	1862592	17	17	17	4	3	6	4	2	2	0	0.095	1.00
54	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B3GNT6(1), B4GALT5(3), C1GALT1C1(1), GALNT1(1), GALNT10(2), GALNT11(2), GALNT12(3), GALNT14(4), GALNT2(4), GALNT3(2), GALNT5(6), GALNT6(2), GALNT7(1), GALNT8(2), GALNTL1(3), GALNTL2(1), GALNTL4(4), GALNTL5(3), GCNT1(3), GCNT3(3), OGT(2), ST3GAL1(1), ST3GAL2(2), ST6GALNAC1(6)	8069986	62	53	60	20	9	31	14	3	5	0	0.096	1.00
55	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(12), EP300(5), LPL(3), NCOA1(6), NCOA2(10), RXRA(1)	4966378	37	34	36	14	6	16	7	3	5	0	0.10	1.00
56	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(6), ADORA2B(1), P2RY1(1), P2RY2(2), P2RY6(2)	1601110	16	15	16	5	7	7	1	0	1	0	0.11	1.00
57	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), CNR2(3), DNMT1(4), MTNR1A(1), PTAFR(3), PTGDR(5), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), TBXA2R(2)	2971888	27	24	27	10	10	9	6	0	2	0	0.11	1.00
58	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	5	ARG1(2), ASL(2), GLS(2), GLUD1(3), GOT1(2)	1178716	11	11	10	3	1	7	1	0	2	0	0.11	1.00
59	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(4), EGF(6), EGFR(9), HRAS(2), MAP2K1(2), MAPK1(1), MAPK3(2), PTPRB(15), RAF1(1), RASA1(6), SHC1(1), SOS1(6)	6589916	55	42	54	11	15	19	8	3	10	0	0.11	1.00
60	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA4(1), ANXA5(2), ANXA6(6), CYP11A1(2), EDN1(1), EDNRA(2), EDNRB(5), HSD11B1(3), HSD11B2(1), PLA2G4A(5), PRL(1), PTGDR(5), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), PTGS1(2), TBXAS1(5)	5652568	47	39	45	15	9	19	8	3	8	0	0.12	1.00
61	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(2), ABLIM1(2), ABLIM2(2), ABLIM3(2), ARHGEF12(3), CDC42(1), CDK5(2), CFL1(3), CFL2(1), CHP(2), DCC(12), DPYSL2(2), DPYSL5(5), EFNA1(1), EFNA3(1), EFNB1(2), EFNB2(1), EPHA1(4), EPHA2(1), EPHA3(6), EPHA4(1), EPHA7(7), EPHA8(3), EPHB2(5), EPHB3(9), EPHB4(2), EPHB6(4), FES(1), FYN(4), GNAI1(2), GNAI3(1), GSK3B(1), HRAS(2), ITGB1(4), KRAS(1), L1CAM(2), LIMK1(1), LIMK2(1), MAPK1(1), MAPK3(2), MET(3), NCK1(3), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NGEF(1), NRP1(4), NTN1(2), NTN4(1), NTNG1(1), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PLXNA1(10), PLXNA2(6), PLXNA3(3), PLXNB1(4), PLXNB3(3), PLXNC1(9), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PTK2(3), RAC1(2), RASA1(6), RGS3(4), ROBO1(7), ROBO2(6), ROBO3(5), ROCK1(5), ROCK2(3), SEMA3A(3), SEMA3B(1), SEMA3C(5), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(2), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(5), SEMA4G(1), SEMA5A(7), SEMA5B(4), SEMA6C(4), SEMA6D(6), SEMA7A(1), SLIT1(4), SLIT2(9), SLIT3(11), SRGAP1(2), SRGAP2(5), SRGAP3(3), UNC5B(2), UNC5C(6)	51489348	334	133	334	137	80	124	53	29	48	0	0.12	1.00
62	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(5), HDC(3), PNMT(2), TH(2), TPH1(1)	1656468	15	14	15	3	3	7	2	1	2	0	0.12	1.00
63	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), DRD1(1), DRD2(2), EGF(6), EGFR(9), GJA1(4), GJD2(2), GNAI1(2), GNAI3(1), GNAS(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(8), HRAS(2), HTR2A(1), HTR2B(2), HTR2C(3), ITPR1(5), ITPR2(11), ITPR3(3), KRAS(1), MAP2K1(2), MAP2K2(2), MAP2K5(2), MAPK1(1), MAPK3(2), MAPK7(1), NPR1(2), NPR2(5), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(5), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(5), PRKX(1), RAF1(1), SOS1(6), SOS2(4), TJP1(9), TUBA1B(1), TUBA3C(5), TUBA3D(4), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB4(4), TUBB4Q(2), TUBB8(2)	33858982	251	118	249	86	81	85	40	20	25	0	0.14	1.00
64	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	80	AGRN(2), CD36(1), CD44(3), CD47(2), COL11A2(10), COL1A1(8), COL1A2(15), COL2A1(8), COL3A1(10), COL4A1(11), COL4A2(9), COL4A4(9), COL4A6(9), COL5A1(5), COL5A2(12), COL5A3(11), COL6A3(12), DAG1(1), FN1(17), FNDC1(7), FNDC3A(1), GP5(4), GP6(3), GP9(1), HMMR(1), HSPG2(8), IBSP(4), ITGA1(4), ITGA10(6), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGA7(3), ITGA8(9), ITGA9(1), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(2), ITGB7(1), ITGB8(3), LAMA1(14), LAMA2(17), LAMA3(7), LAMA4(15), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(4), LAMC3(1), RELN(26), SDC3(1), SV2A(3), SV2B(3), SV2C(3), THBS1(1), THBS3(4), TNC(16), TNXB(16), VWF(16)	57882752	433	140	432	146	120	167	80	21	45	0	0.14	1.00
65	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(2), ALDOC(1), TPI1(4)	1036850	10	10	9	3	5	3	2	0	0	0	0.14	1.00
66	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(1), UGDH(3), UGP2(5), UXS1(3)	1352088	14	12	14	1	0	7	4	1	2	0	0.15	1.00
67	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), ADRB2(3), CFTR(4), GNAS(4), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	3468864	29	26	29	9	10	8	6	2	3	0	0.15	1.00
68	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(12), DFFA(1), DFFB(2), GZMA(4), GZMB(1), PRF1(2)	2860104	23	22	23	8	7	7	3	2	4	0	0.15	1.00
69	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(1), CUL1(3), E2F1(3), RB1(7)	1838028	14	14	14	1	1	7	0	0	6	0	0.15	1.00
70	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(2), GOT2(3), TAT(1), TYR(3)	1255434	11	11	10	2	3	6	0	1	1	0	0.15	1.00
71	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(3), IL16(8), IL4(2), LTA(3)	2643656	21	21	21	5	4	7	5	3	2	0	0.16	1.00
72	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(6), ABAT(3), ACY3(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(2), ASL(2), ASNS(3), ASPA(1), ASS1(4), CAD(10), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(5), GAD2(5), GOT1(2), GOT2(3), GPT(1), GPT2(2), NARS(3), NARS2(2), PC(4), PDHA1(2), PDHA2(5)	10270600	83	61	80	27	22	37	10	6	8	0	0.16	1.00
73	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(8), AKT1(1), CAMK2B(2), CAMK2D(1), GNAS(4), HRAS(2), MAPK1(1), MAPK14(1), MAPK3(2), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), RAC1(2), RPS6KA1(4), RPS6KA5(3), SOS1(6)	7232318	53	45	53	11	14	16	13	5	5	0	0.16	1.00
74	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CKS1B(1), CUL1(3), E2F1(3), RB1(7), RBX1(1), SKP2(1), UBE2M(1)	2348354	18	17	18	1	3	7	0	1	7	0	0.17	1.00
75	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	6	EPX(5), GBA3(6), LPO(2), MPO(3), PRDX6(1)	1850310	17	15	17	6	3	4	9	0	1	0	0.18	1.00
76	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	133	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), ADRA1A(2), ADRA1B(4), ADRA1D(2), ADRB2(3), ANXA6(6), ARRB1(3), ATP1A4(4), ATP1B2(1), ATP2A2(6), ATP2A3(2), ATP2B1(4), ATP2B2(6), ATP2B3(3), CACNA1A(8), CACNA1B(1), CACNA1C(16), CACNA1D(3), CACNA1E(16), CACNA1S(8), CACNB1(1), CACNB3(2), CALR(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(1), CHRM2(6), CHRM3(5), CHRM4(1), CHRM5(2), GJA1(4), GJB2(1), GJB4(1), GJB5(1), GNAI3(1), GNAZ(2), GNB1(1), GNB2(3), GNB3(2), GNB4(2), GNB5(1), GNG12(1), GNG3(1), GNG4(2), GNG5(1), GRK4(1), GRK5(2), GRK6(1), ITPR1(5), ITPR2(11), ITPR3(3), KCNB1(1), KCNJ5(2), MIB1(2), NME7(2), PEA15(1), PLCB3(4), PLN(1), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCQ(4), PRKD1(9), RGS1(2), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(2), RGS6(4), RGS9(2), RYR1(29), SFN(2), SLC8A3(3), USP5(3), YWHAB(2), YWHAQ(1)	44979888	331	123	330	113	98	133	43	23	34	0	0.18	1.00
77	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	17	CALCR(6), CALCRL(4), CRHR1(4), CRHR2(3), EMR1(9), EMR2(5), GHRHR(3), GLP1R(1), GLP2R(4), GPR64(3), LPHN1(4), LPHN2(6)	6101662	52	40	52	21	13	18	10	4	7	0	0.18	1.00
78	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(11), COL4A2(9), COL4A3(5), COL4A4(9), COL4A5(3), COL4A6(9), SLC23A1(1), SLC23A2(4), SLC2A3(4)	6862612	55	44	55	18	18	25	4	1	7	0	0.18	1.00
79	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD4(2), CREBBP(12), GNAS(4), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PTPRC(3), ZAP70(3)	6185678	48	40	48	17	15	18	5	4	6	0	0.20	1.00
80	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD4(2), CREBBP(12), GNAS(4), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PTPRC(3), ZAP70(3)	6185678	48	40	48	17	15	18	5	4	6	0	0.20	1.00
81	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ADCY3(5), ADCY9(4), ARF5(3), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(2), PLCG2(3), PRKCA(5), SEC61A1(4), SEC61A2(1), TRIM23(2)	9803528	62	54	62	21	18	18	16	4	6	0	0.20	1.00
82	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(3)	802958	7	6	7	1	1	1	2	0	3	0	0.20	1.00
83	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	32	ALDH4A1(3), ARG1(2), ASL(2), ASS1(4), CKB(1), CKM(2), CKMT2(1), DAO(1), EPRS(11), GATM(1), GLUD1(3), GOT1(2), GOT2(3), LAP3(1), NOS1(10), NOS3(1), OTC(2), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(1), RARS(4), RARS2(2)	8582448	65	51	62	18	14	27	12	2	10	0	0.21	1.00
84	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	133	ACTA1(2), ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), ARRB1(3), ATF2(2), ATF4(1), ATP2A2(6), ATP2A3(2), CACNB3(2), CALCA(1), CAMK2B(2), CAMK2D(1), CNN1(1), CNN2(1), CORIN(6), CREB3(2), CRHR1(4), DGKZ(3), FOS(1), GABPA(2), GABPB2(1), GBA2(2), GJA1(4), GNB1(1), GNB2(3), GNB3(2), GNB4(2), GNB5(1), GNG12(1), GNG3(1), GNG4(2), GNG5(1), GRK4(1), GRK5(2), GRK6(1), GSTO1(1), GUCA2B(1), GUCY1A3(6), IGFBP3(1), IGFBP6(1), IL1B(1), ITPR1(5), ITPR2(11), ITPR3(3), JUN(2), MIB1(2), MYL2(1), MYLK2(2), NFKB1(2), NOS1(10), NOS3(1), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(4), PLCG1(2), PLCG2(3), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(5), PRKCH(1), PRKCQ(4), PRKD1(9), RAMP2(1), RGS1(2), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(2), RGS6(4), RGS9(2), RYR1(29), SFN(2), SP1(1), TNXB(16), USP5(3), YWHAB(2), YWHAQ(1)	41029356	284	121	283	103	90	115	38	14	27	0	0.22	1.00
85	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CSAD(1), GAD1(5), GAD2(5), GGT1(2)	1577970	16	13	16	10	4	7	2	2	1	0	0.22	1.00
86	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	22	ABAT(3), ALDH4A1(3), ALDH5A1(1), CAD(10), EPRS(11), GAD1(5), GAD2(5), GCLC(2), GCLM(1), GLS(2), GLUD1(3), GLUL(1), GOT1(2), GOT2(3), GPT(1), GPT2(2), GSS(2), PPAT(1)	7688176	58	47	57	18	11	29	11	3	4	0	0.22	1.00
87	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(14), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(3)	2728562	21	20	21	9	4	11	3	2	1	0	0.22	1.00
88	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(7), PLCB2(5), PRL(1), VIP(2)	3042376	26	23	26	8	10	10	3	2	1	0	0.22	1.00
89	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(8), CAP1(1), CCNB1(1), CDC25C(1), GNAI1(2), GNAS(4), GNB1(1), HRAS(2), MAPK1(1), MAPK3(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), RPS6KA1(4)	5515508	39	36	39	14	11	14	7	5	2	0	0.23	1.00
90	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(2)	1077612	9	9	9	2	1	3	2	1	2	0	0.23	1.00
91	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(1), AKT3(2), BRAF(7), CAB39(1), DDIT4(2), EIF4B(6), FIGF(1), HIF1A(1), IGF1(2), MAPK1(1), MAPK3(2), PDPK1(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PRKAA2(2), RHEB(1), RICTOR(4), RPS6(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3), RPS6KB1(1), STK11(3), TSC1(6), TSC2(6), ULK1(1), ULK2(3), VEGFC(4)	14056126	92	70	90	29	20	29	22	7	14	0	0.23	1.00
92	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(2), EPHA4(1), FYN(4), ITGA1(4), ITGB1(4), L1CAM(2), LYN(1), SELP(8)	3687448	26	24	26	14	6	4	7	1	8	0	0.24	1.00
93	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(5), CD14(1), CD19(2), CD1A(4), CD1B(5), CD1C(5), CD1D(3), CD1E(4), CD2(1), CD22(5), CD33(2), CD34(3), CD36(1), CD37(2), CD38(1), CD3D(1), CD4(2), CD44(3), CD5(3), CD8B(1), CD9(2), CR1(4), CR2(9), CSF1(2), CSF1R(3), CSF3R(5), DNTT(3), EPOR(2), FCER2(2), FCGR1A(1), FLT3(4), GP5(4), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(2), IL1B(1), IL1R2(3), IL4(2), IL5RA(2), IL6R(1), IL7R(3), ITGA1(4), ITGA2(5), ITGA2B(1), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGAM(3), ITGB3(3), KIT(6), MME(6), MS4A1(3), TFRC(2), THPO(1)	21426928	162	95	162	67	44	70	28	4	16	0	0.24	1.00
94	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(4), BDKRB1(3), BDKRB2(1), C1QA(2), C1QB(2), C1R(2), C1S(4), C2(1), C3(4), C3AR1(1), C4BPA(1), C5(1), C5AR1(1), C7(7), C8A(3), C8B(2), C9(2), CD46(2), CFB(3), CFH(5), CFI(2), CPB2(2), CR1(4), CR2(9), F10(3), F11(4), F12(1), F13A1(3), F13B(7), F2R(2), F3(2), F5(15), F8(10), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), KNG1(4), MASP1(10), MASP2(1), MBL2(3), PLAT(1), PLAU(2), PLG(2), SERPINA1(1), SERPINA5(2), SERPINC1(5), SERPIND1(1), SERPINE1(2), SERPINF2(3), VWF(16)	24079306	185	99	184	64	48	67	43	13	14	0	0.25	1.00
95	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(1), AKR1D1(4), ARSD(1), ARSE(2), CARM1(1), CYP11B2(6), CYP19A1(3), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(1), HSD17B7(1), HSD3B1(4), HSD3B2(5), LCMT1(2), LCMT2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), WBSCR22(4)	12726110	94	66	93	17	27	28	19	11	9	0	0.26	1.00
96	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(3), ADSL(1), ADSS(1), AGXT2(2), ASL(2), ASNS(3), ASPA(1), CAD(10), DARS(1), DDO(2), GAD1(5), GAD2(5), GOT1(2), GOT2(3), GPT(1), GPT2(2), NARS(3), PC(4)	7056632	53	43	52	20	12	26	7	3	5	0	0.26	1.00
97	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(2), C1QB(2), C1R(2), C1S(4), C2(1), C3(4), C5(1), C7(7), C8A(3), C9(2), MASP1(10), MASP2(1), MBL2(3)	5353528	42	34	42	15	9	17	9	3	4	0	0.26	1.00
98	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(6), DARS(1), EPRS(11), FARS2(1), GARS(1), HARS(2), IARS(3), KARS(3), LARS2(5), MARS(1), NARS(3), RARS(4), SARS(2), TARS(3), WARS(4), WARS2(1), YARS(1)	8565716	54	50	54	18	9	21	17	2	5	0	0.27	1.00
99	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(11), PDXP(1)	1306342	12	11	12	2	2	5	2	3	0	0	0.27	1.00
100	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), CYP1A2(1), CYP2C19(6), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), RDH11(2), RDH12(2), RDH13(1)	6442710	48	40	48	16	16	13	8	4	7	0	0.27	1.00
101	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	CDK5(2), DRD1(1), DRD2(2), PLCB1(7), PPP1CA(1), PPP1R1B(1), PPP3CA(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	3577444	26	25	26	6	9	12	0	2	3	0	0.28	1.00
102	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), ALDOC(1), DLAT(1), DLD(2), ENO2(2), ENO3(1), FBP2(1), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GOT2(3), GPI(5), HK1(4), HK2(6), HK3(7), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), PC(4), PCK1(3), PDHA1(2), PDHA2(5), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGK1(1), PGK2(5), PKLR(3), PKM2(1), TPI1(4)	11286268	90	64	87	27	28	38	10	5	9	0	0.28	1.00
103	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(8), AKT1(1), BAX(1), BCL2L1(2), CSF2RB(5), IGF1(2), IGF1R(1), KIT(6), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	5036332	37	34	37	8	12	15	4	3	3	0	0.28	1.00
104	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(6), KARS(3)	1265758	11	11	11	3	3	4	3	0	1	0	0.28	1.00
105	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	134924	1	1	1	0	0	0	1	0	0	0	0.28	1.00
106	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(8), STAT1(2), STAT2(2), TYK2(8)	3290686	24	24	23	6	7	11	1	3	2	0	0.28	1.00
107	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	28	ABAT(3), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(10), EARS2(2), EPRS(11), GAD1(5), GAD2(5), GCLC(2), GCLM(1), GFPT2(1), GLS(2), GLUD1(3), GLUL(1), GOT1(2), GOT2(3), GPT(1), GPT2(2), GSR(2), GSS(2), PPAT(1)	9113066	64	51	63	22	11	31	12	5	5	0	0.28	1.00
108	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), GOT1(2), GOT2(3), LDHB(2), LDHC(1)	1840164	14	13	13	2	1	6	3	2	2	0	0.28	1.00
109	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(5), GLI3(6), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), SMO(1), SUFU(3)	4465486	31	29	31	15	5	16	4	3	3	0	0.29	1.00
110	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(1), PIK3R1(1), PLCB1(7), PLCG1(2), PRKCA(5), VAV1(7)	2863130	23	21	23	7	7	8	3	4	1	0	0.29	1.00
111	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), GSTZ1(2)	353152	3	3	3	0	1	0	0	1	1	0	0.30	1.00
112	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(5), CHIT1(5), CMAS(2), CTBS(4), CYB5R1(2), GFPT2(1), GNE(4), GNPDA2(3), HEXA(6), HK1(4), HK2(6), HK3(7), MTMR1(1), MTMR2(1), MTMR6(3), NANS(1), UAP1(1)	7756350	57	45	57	17	14	24	7	3	9	0	0.30	1.00
113	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(8), CREM(2), FSHB(1), GNAS(4), XPO1(2)	2218948	17	16	17	8	6	4	3	3	1	0	0.31	1.00
114	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(6), AOC2(2), AOC3(3), CES1(2)	1611612	13	12	13	8	4	5	2	2	0	0	0.31	1.00
115	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(3), TAT(1)	702744	6	6	5	2	2	3	0	1	0	0	0.32	1.00
116	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(6), ACADL(2), ACADM(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), EHHADH(1), GAD1(5), GAD2(5), HADHA(2), MLYCD(2), SDS(2), SMS(4)	7843214	63	46	62	25	15	28	9	5	6	0	0.32	1.00
117	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), GPI(5), HK1(4), PFKL(2), PGK1(1), PKLR(3), TPI1(4)	2381818	21	17	20	4	8	6	4	0	3	0	0.33	1.00
118	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(2), GLS(2), GLUD1(3)	1445894	10	10	10	4	1	6	2	0	1	0	0.34	1.00
119	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(9), APC2(2), BTRC(1), CAMK2B(2), CAMK2D(1), CCND1(1), CCND2(3), CCND3(1), CHD8(13), CHP(2), CREBBP(12), CSNK1A1(1), CSNK1A1L(5), CSNK2A1(2), CTBP1(1), CTNNB1(3), CUL1(3), DAAM1(1), DAAM2(5), DKK1(3), DKK2(1), DKK4(1), DVL1(3), DVL3(3), EP300(5), FZD1(1), FZD10(2), FZD3(4), FZD4(1), FZD6(1), FZD9(3), GSK3B(1), JUN(2), LEF1(3), LRP5(6), LRP6(6), MAP3K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NKD1(1), NKD2(2), NLK(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PORCN(2), PPARD(2), PPP2R1A(6), PPP2R1B(2), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRICKLE1(5), PRICKLE2(1), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PSEN1(1), RAC1(2), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(1), SENP2(3), SFRP1(1), SFRP4(3), SIAH1(1), SKP1(1), SMAD2(2), SMAD4(2), TBL1XR1(2), TBL1Y(2), TCF7(1), VANGL1(1), VANGL2(2), WIF1(4), WNT10B(2), WNT11(2), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(2)	44342292	275	126	272	98	80	99	39	27	30	0	0.34	1.00
120	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(1), GPR109B(3), GPR161(2), GPR171(2), GPR18(1), GPR34(1), GPR39(1), GPR45(4), GPR65(1), GPR68(1), GPR75(2)	2642232	22	19	22	8	8	9	4	0	1	0	0.34	1.00
121	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(1), ALDOB(2), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME3(2), PGK1(1), PGK2(5), PKLR(3), PKM2(1), RPIA(1), TKT(1), TKTL1(4), TPI1(4)	4972608	37	33	33	14	11	15	5	2	4	0	0.34	1.00
122	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CLOCK(5), CRY1(3), CRY2(2), EIF4G2(4), ETV6(4), GSTM3(1), HERPUD1(2), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(5), PER1(6), PER2(3), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(1), UCP3(3), UGP2(5), VAPA(1), ZFR(4)	9949310	64	53	64	15	11	22	17	4	10	0	0.35	1.00
123	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(3), F2R(2), FGA(5), FGB(3), FGG(1), PLAT(1), PLAU(2), PLG(2), SERPINB2(3), SERPINE1(2)	3573172	26	24	25	9	3	13	8	0	2	0	0.35	1.00
124	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPT(2), ENPP1(7), ENPP3(4), FLAD1(2), TYR(3)	2593104	19	18	19	5	5	10	2	0	2	0	0.35	1.00
125	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(3), OCRL(5), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(1), PIK3CG(10), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLCG1(2), PLCG2(3)	11733582	80	60	80	28	26	21	17	6	10	0	0.35	1.00
126	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(2), C1QB(2), C1R(2), C1S(4), C2(1), C3(4), C5(1), C7(7), C8A(3), C8B(2), C9(2), MASP1(10)	5207568	40	32	40	16	10	15	9	3	3	0	0.36	1.00
127	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ABP1(6), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(2), CKB(1), CKM(2), CKMT2(1), DAO(1), GATM(1), GLUD1(3), GOT1(2), GOT2(3), NOS1(10), NOS3(1), ODC1(1), OTC(2), P4HA1(2), P4HA2(3), P4HA3(3), RARS(4), SMS(4)	11077830	74	59	72	26	16	32	11	4	11	0	0.36	1.00
128	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(4), GNB1(1), PRKAA2(2), PRKAB2(1), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	4084922	30	26	30	8	10	10	5	2	3	0	0.36	1.00
129	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(3), AGTR2(4), BDKRB2(1), KNG1(4), NOS3(1)	2766476	18	18	18	11	4	7	4	1	2	0	0.36	1.00
130	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(12), EP300(5), ESR1(6), MAPK1(1), MAPK3(2), PELP1(1)	4039354	27	26	26	6	6	10	6	2	3	0	0.37	1.00
131	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(2), FOS(1), HRAS(2), INSR(7), IRS1(4), JUN(2), MAP2K1(2), MAPK3(2), MAPK8(2), PIK3R1(1), PTPN11(3), RAF1(1), RASA1(6), SHC1(1), SLC2A4(2), SOS1(6), SRF(2)	6296750	46	38	46	9	12	16	7	5	6	0	0.37	1.00
132	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), EGR1(4), HRAS(2), KLK2(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), NGFR(1), RAF1(1)	2270034	18	16	17	4	5	9	2	1	1	0	0.37	1.00
133	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(1), EIF4A1(3), EIF4A2(3), EIF4B(6), EIF4G1(8), EIF4G2(4), EIF4G3(3), PDK2(2), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1), TSC1(6), TSC2(6)	6686392	46	37	45	14	5	21	9	3	8	0	0.37	1.00
134	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), BTRC(1), CCND1(1), CREBBP(12), CSNK1A1(1), CSNK2A1(2), CTBP1(1), CTNNB1(3), DVL1(3), FZD1(1), GSK3B(1), HDAC1(2), MAP3K7(3), MYC(1), NLK(2), PPARD(2), TLE1(4), WIF1(4)	7875610	53	46	53	11	10	20	10	5	8	0	0.37	1.00
135	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(2), DBH(2), DDC(2), GAD1(5), GAD2(5), HDC(3), PAH(1), PNMT(2), TH(2), TPH1(1)	3978300	27	25	27	11	9	11	4	1	2	0	0.37	1.00
136	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(12), DAXX(3), HRAS(2), PAX3(3), RARA(1), RB1(7), SIRT1(1), SP100(1), TNFRSF1A(2), TNFRSF1B(1)	5006962	33	28	33	10	7	12	2	4	8	0	0.38	1.00
137	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(3), MMP2(4), MMP9(6), RECK(3), TIMP2(1)	2030980	19	14	19	4	3	10	3	2	1	0	0.38	1.00
138	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(1), ALOX15(2), CYP4F2(3), CYP4F3(3), EPX(5), GGT1(2), LPO(2), LTA4H(2), MPO(3), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PRDX1(1), PRDX6(1), PTGS1(2), TBXAS1(5)	7134062	51	42	49	25	11	17	15	3	5	0	0.38	1.00
139	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2)	3417422	22	20	22	11	3	7	6	0	6	0	0.39	1.00
140	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(1), BLNK(1), FOS(1), HRAS(2), JUN(2), LYN(1), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(2), MAPK8IP3(6), PAPPA(8), RAC1(2), RPS6KA1(4), RPS6KA3(1), SHC1(1), SOS1(6), SYK(1), VAV1(7), VAV2(4), VAV3(1)	8747988	59	49	59	14	14	19	15	6	5	0	0.39	1.00
141	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDK2(1), CUL1(3), E2F1(3), RB1(7), SKP2(1)	2358678	16	15	16	1	3	7	0	0	6	0	0.40	1.00
142	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(2), B4GALT4(1), CHST1(2), CHST2(4), CHST4(2), CHST6(3), FUT8(2), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2)	3427212	25	23	24	16	9	10	4	2	0	0	0.40	1.00
143	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(9), ERBB3(3), NRG1(4), UBE2D1(1)	2762204	23	18	22	5	6	8	3	2	4	0	0.40	1.00
144	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	192952	1	1	1	0	0	0	0	0	1	0	0.40	1.00
145	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), ATF4(1), CACNA1C(16), CACNA1D(3), CACNA1F(8), CACNA1S(8), CAMK2B(2), CAMK2D(1), CDC42(1), EGFR(9), FSHB(1), GNAS(4), HBEGF(1), HRAS(2), ITPR1(5), ITPR2(11), ITPR3(3), JUN(2), KRAS(1), LHB(1), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(3), MMP2(4), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLD1(10), PLD2(4), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCD(2), PRKX(1), RAF1(1), SOS1(6), SOS2(4)	34618686	232	114	229	74	73	85	37	17	20	0	0.40	1.00
146	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), ADSL(1), ADSS(1), ADSSL1(1), AK5(2), AK7(1), AMPD1(4), AMPD2(1), AMPD3(6), CANT1(3), DCK(1), ENPP1(7), ENPP3(4), ENTPD1(1), ENTPD2(1), ENTPD3(1), ENTPD5(1), ENTPD6(3), GART(2), GDA(6), GUCY1A3(6), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(8), GUK1(1), HPRT1(1), IMPDH1(2), NME4(1), NME7(2), NPR1(2), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(4), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(5), PDE11A(11), PDE1A(2), PDE2A(3), PDE3B(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(3), PDE6H(2), PDE7B(1), PDE8A(6), PDE8B(2), PDE9A(2), PFAS(5), PKLR(3), PKM2(1), PNPT1(2), POLA1(5), POLA2(3), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(4), POLR1B(4), POLR1C(1), POLR1D(1), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1), POLR3A(3), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(1), PRIM1(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RFC5(2), RRM1(2), RRM2B(2), XDH(9)	43127264	258	121	255	112	78	102	39	13	26	0	0.40	1.00
147	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(2)	579390	4	4	4	1	1	1	1	1	0	0	0.41	1.00
148	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(5), AMY2B(5), ENPP1(7), ENPP3(4), G6PC(2), GANAB(5), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(3), GYS1(1), GYS2(3), HK1(4), HK2(6), HK3(7), MGAM(5), PGM1(1), PYGB(2), PYGM(6), UGDH(3), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1), UGT2B4(4), UXS1(3)	14193898	101	68	100	31	29	41	17	6	8	0	0.41	1.00
149	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(1), ARHGEF2(6), CD14(1), CDC42(1), CDH1(4), CLDN1(2), CTNNB1(3), CTTN(4), EZR(1), FYN(4), HCLS1(3), ITGB1(4), KRT18(2), NCK1(3), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR5(3), TUBA1B(1), TUBA3C(5), TUBA3D(4), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB4(4), TUBB4Q(2), TUBB8(2), WAS(5), WASL(2), YWHAQ(1)	13876346	93	66	93	34	21	35	15	10	12	0	0.42	1.00
150	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(1), ARHGEF2(6), CD14(1), CDC42(1), CDH1(4), CLDN1(2), CTNNB1(3), CTTN(4), EZR(1), FYN(4), HCLS1(3), ITGB1(4), KRT18(2), NCK1(3), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR5(3), TUBA1B(1), TUBA3C(5), TUBA3D(4), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB4(4), TUBB4Q(2), TUBB8(2), WAS(5), WASL(2), YWHAQ(1)	13876346	93	66	93	34	21	35	15	10	12	0	0.42	1.00
151	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(2), GNS(1), GUSB(3), HEXA(6), HGSNAT(2), HPSE(3), HPSE2(4), HYAL1(4), IDS(1), IDUA(2), SPAM1(3)	4588306	31	27	30	6	4	13	7	1	6	0	0.42	1.00
152	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(7), SP1(1), SP3(1)	1794596	10	10	10	1	1	3	0	0	6	0	0.42	1.00
153	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(6), ACADM(1), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), EHHADH(1), GAD1(5), GAD2(5), HADHA(2), HIBCH(1), MLYCD(2), SMS(4)	7313308	57	42	57	24	16	24	7	5	5	0	0.43	1.00
154	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(3), DNM1(1), EPN1(3), EPS15(4), PICALM(3), PPP3CA(2), PPP3CB(5), PPP3CC(2), SYNJ1(2), SYNJ2(5), SYT1(3)	6051110	40	36	40	11	10	12	6	5	7	0	0.43	1.00
155	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(1), GNE(4), GNPDA2(3), HEXA(6), HK1(4), HK2(6), HK3(7), UAP1(1)	4584390	34	30	34	9	8	16	3	3	4	0	0.43	1.00
156	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), GRIA2(3), PPP1R1B(1)	1061414	6	6	6	6	0	2	1	0	3	0	0.43	1.00
157	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(7), CPEB1(2), EGFR(9), ERBB2(3), ERBB4(9), ETS1(2), ETV6(4), ETV7(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(2), NOTCH1(11), NOTCH2(7), NOTCH3(5), NOTCH4(3), PIWIL1(5), PIWIL2(4), PIWIL3(4), PIWIL4(1), RAF1(1), SOS1(6), SOS2(4), SPIRE1(1)	13594750	95	66	94	29	21	36	12	8	18	0	0.44	1.00
158	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(2), BLVRA(2), COX10(1), CP(3), CPOX(3), EARS2(2), EPRS(11), FECH(2), FTH1(4), FTMT(4), GUSB(3), HMBS(2), HMOX1(1), MMAB(1), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UROD(1)	10816526	76	58	76	15	17	31	17	5	6	0	0.44	1.00
159	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	FOS(1), JUN(2), MAPK1(1), MAPK14(1), MAPK8(2), PRKCA(5)	1727846	12	12	12	3	4	3	3	1	1	0	0.45	1.00
160	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(4), ACACB(8), AKT1(1), AKT3(2), ARAF(3), BRAF(7), CBL(4), CBLB(4), CRKL(1), EXOC7(2), FBP2(1), FLOT1(2), G6PC(2), G6PC2(2), GCK(1), GSK3B(1), GYS1(1), GYS2(3), HRAS(2), IKBKB(3), INPP5D(6), INSR(7), IRS1(4), IRS2(2), IRS4(3), KRAS(1), LIPE(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), PCK1(3), PCK2(1), PDE3A(5), PDE3B(3), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PHKA1(4), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PKLR(3), PKM2(1), PPARGC1A(5), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3C(2), PPP1R3D(2), PRKAA2(2), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAG3(2), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCI(4), PRKX(1), PTPN1(1), PTPRF(7), PYGB(2), PYGM(6), RAF1(1), RAPGEF1(3), RHEB(1), RPS6(1), RPS6KB1(1), SHC1(1), SHC2(3), SHC3(3), SHC4(4), SLC2A4(2), SOCS2(1), SORBS1(5), SOS1(6), SOS2(4), SREBF1(3), TRIP10(2), TSC1(6), TSC2(6)	42874504	261	120	260	99	64	105	46	15	31	0	0.45	1.00
161	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(1), AKT1(1), AKT3(2), BTK(5), GSK3A(4), GSK3B(1), IARS(3), INPP5D(6), PDK1(1), PPP1R13B(4), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SOS1(6), SOS2(4), TEC(2), YWHAB(2), YWHAE(1), YWHAQ(1)	8850516	55	47	55	14	8	18	13	3	13	0	0.45	1.00
162	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(3), CDK7(1), CHEK1(4), NEK1(3), WEE1(2)	1979716	13	13	13	1	3	7	2	0	1	0	0.45	1.00
163	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), PER1(6)	2337496	18	16	18	3	2	7	7	1	1	0	0.45	1.00
164	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), CFL1(3), GNAS(4), GNB1(1), HRAS(2), LIMK1(1), MAP2K1(2), MAPK1(1), MAPK3(2), MYL2(1), NOX1(2), PIK3C2G(7), PLCB1(7), PPP1R12B(3), PRKCA(5), PTK2(3), RAF1(1), ROCK2(3)	6923488	49	41	49	18	15	20	7	3	4	0	0.45	1.00
165	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(4), CR2(9), FCGR2B(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3)	4122124	28	26	28	13	8	9	4	5	2	0	0.46	1.00
166	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ABP1(6), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH3B2(2), AOC2(2), AOC3(3), AOX1(11), DBH(2), DCT(1), DDC(2), FAH(1), GOT1(2), GOT2(3), GSTZ1(2), HPD(3), PNMT(2), TAT(1), TH(2), TYR(3)	7878636	55	45	54	19	16	26	4	7	2	0	0.47	1.00
167	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(10), ASH2L(1), CARM1(1), CTCFL(2), DOT1L(5), EED(2), EHMT2(2), EZH1(4), EZH2(3), FBXO11(4), HSF4(1), JMJD6(1), KDM6A(3), MEN1(4), MLL(5), MLL3(22), MLL4(6), MLL5(4), NSD1(11), OGT(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(6), PRDM9(11), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), RBBP5(1), SATB1(3), SETD1A(6), SETD2(5), SETD8(1), SETDB1(5), SMYD3(1), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(1), SUZ12(2), WHSC1(2), WHSC1L1(12)	30009554	166	103	165	55	39	53	32	11	29	2	0.47	1.00
168	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(2), CYP2A6(3), NAT2(1), XDH(9)	2131550	16	14	16	7	4	8	1	1	2	0	0.47	1.00
169	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3)	455858	3	3	3	0	0	2	1	0	0	0	0.47	1.00
170	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(12), RANGAP1(4)	2248318	18	16	17	7	3	8	3	2	2	0	0.47	1.00
171	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(2), NFKB1(2), NOX1(2), RELA(3), XDH(9)	2705600	20	16	20	4	5	6	2	4	3	0	0.47	1.00
172	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRA(1), HLA-DRB1(1)	650412	4	4	4	1	1	1	0	0	2	0	0.48	1.00
173	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(1), HRAS(2), KLK2(1), NTRK1(3), PIK3R1(1), PLCG1(2), PRKCA(5), SHC1(1), SOS1(6)	3626928	22	21	22	7	3	8	6	2	3	0	0.48	1.00
174	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST8SIA1(2)	1506770	10	10	9	7	2	4	3	0	1	0	0.48	1.00
175	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(1), UGDH(3), UXS1(3)	1073162	9	7	9	1	0	5	2	1	1	0	0.48	1.00
176	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(3), FUT5(4), FUT6(2)	1397656	9	8	9	3	2	3	3	1	0	0	0.49	1.00
177	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(6), GGT1(2)	1181208	8	7	8	7	1	2	3	1	1	0	0.49	1.00
178	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(4), CREBBP(12), EP300(5), MAP2K1(2), MAP3K7(3), MAPK3(2), TGFB1(1), TGFB2(1), TGFBR2(3)	6897500	42	38	41	11	8	15	10	3	6	0	0.49	1.00
179	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT9(1), GBGT1(3), GLA(2), HEXA(6), NAGA(1), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2), ST8SIA1(2)	2748498	20	17	19	7	2	11	4	2	1	0	0.49	1.00
180	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), GABARAP(1), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(3), PIK3R4(6), PRKAA2(2), ULK1(1), ULK2(3)	5718962	34	31	34	10	10	9	11	1	3	0	0.49	1.00
181	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(3), CADM1(3), CADM3(3), CD2(1), CD22(5), CD226(3), CD276(1), CD34(3), CD4(2), CD40(1), CD40LG(2), CD58(1), CD6(1), CD80(2), CD86(1), CD8B(1), CDH1(4), CDH2(8), CDH3(1), CDH4(6), CDH5(2), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(2), CLDN9(3), CNTN1(9), CNTN2(1), CNTNAP1(7), ESAM(4), F11R(1), GLG1(3), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(5), ITGA6(6), ITGA8(9), ITGA9(1), ITGAL(1), ITGAM(3), ITGAV(3), ITGB1(4), ITGB2(3), ITGB7(1), ITGB8(3), L1CAM(2), MADCAM1(1), MAG(4), MPZ(2), NCAM1(5), NEGR1(2), NEO1(6), NFASC(6), NLGN1(5), NLGN2(1), NLGN3(4), NRCAM(4), NRXN2(8), NRXN3(9), PTPRC(3), PTPRF(7), PTPRM(6), PVRL1(3), PVRL3(2), SDC3(1), SELE(4), SELL(2), SELP(8), SELPLG(1), SIGLEC1(7), VCAM1(4), VCAN(16)	38466512	279	120	278	115	73	112	51	18	25	0	0.50	1.00
182	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(2), CHKA(2), PCYT1A(2), PDHA1(2), PDHA2(5)	1926672	15	14	15	4	4	7	3	1	0	0	0.50	1.00
183	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E3(1), UBE2G2(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE3A(4)	2847644	19	18	19	4	6	7	2	1	3	0	0.50	1.00
184	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(3), ACAT1(1), HADHA(2)	1468678	9	9	9	2	2	3	1	1	2	0	0.51	1.00
185	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(1), BCAR1(5), ILK(1), ITGB1(4), MAPK1(1), MAPK3(2), PDK2(2), PDPK1(1), PIK3R1(1), PTK2(3), SHC1(1), SOS1(6)	4492542	28	25	28	6	8	8	7	2	3	0	0.51	1.00
186	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(2), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(2), IL5RA(2)	1438952	10	9	10	2	2	4	1	0	3	0	0.51	1.00
187	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(3), UGDH(3), UGP2(5), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4)	6739792	44	39	44	10	11	14	13	3	3	0	0.51	1.00
188	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(3), ACPT(2), ENPP1(7), ENPP3(4), FLAD1(2), MTMR1(1), MTMR2(1), MTMR6(3), TYR(3)	4031522	27	24	27	8	7	11	4	0	5	0	0.52	1.00
189	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	8	HK1(4), KHK(1), MPI(1), PGM1(1), PYGM(6), TPI1(4), TREH(1)	2572278	18	17	17	6	6	5	5	0	2	0	0.52	1.00
190	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), LDLR(4), LPL(3)	1424534	10	10	10	2	5	4	1	0	0	0	0.52	1.00
191	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PRKCA(5), TGM2(1)	1368286	10	9	10	3	3	3	3	0	1	0	0.52	1.00
192	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), GOT1(2), GOT2(3), LDHAL6B(1), LDHB(2), LDHC(1), SDS(2), SULT1B1(3), SULT1C2(3), SULT1C4(2)	3393748	25	21	24	4	2	13	6	2	2	0	0.52	1.00
193	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCL3(2), CCR1(2), CCR3(1), CCR4(3), CD4(2), CXCR3(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), TGFB1(1), TGFB2(1)	4906392	32	27	32	14	8	9	7	0	8	0	0.52	1.00
194	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(12), EP300(5), NCOA3(4), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), RARA(1), RXRA(1)	5467804	34	30	33	9	7	14	4	5	4	0	0.53	1.00
195	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(2), CFL1(3), CHN1(2), LIMK1(1), MAP3K1(3), MYL2(1), MYLK(7), NCF2(5), PAK1(3), PDGFRA(8), PIK3R1(1), PLD1(10), PPP1R12B(3), RAC1(2), RALBP1(1), RPS6KB1(1), TRIO(7), VAV1(7)	8864578	67	48	65	26	17	27	13	7	3	0	0.53	1.00
196	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(3)	4317924	25	22	25	11	9	3	7	1	5	0	0.53	1.00
197	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), CHUK(2), DAXX(3), EGF(6), EGFR(9), ETS1(2), FOS(1), HOXA7(3), HRAS(2), IKBKB(3), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAP3K14(1), MAP3K5(3), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK8(2), NFKB1(2), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCQ(4), RAF1(1), RELA(3), SP1(1), TNFRSF1A(2), TNFRSF1B(1)	13433838	92	65	91	24	26	35	14	6	11	0	0.53	1.00
198	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(8), AKT1(1), GNAI1(2), GNB1(1), ITGAV(3), ITGB3(3), MAPK1(1), MAPK3(2), PDGFRA(8), PIK3R1(1), PLCB1(7), PRKCA(5), PTK2(3), RAC1(2), SMPD1(3), SMPD2(2)	6767204	52	39	52	20	16	20	9	6	1	0	0.53	1.00
199	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(9), GNAS(4), GNB1(1), HRAS(2), IGF1R(1), ITGB1(4), KLK2(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), MYC(1), NGFR(1), PDGFRA(8), PTPRR(6), RAF1(1), RPS6KA1(4), RPS6KA5(3), SHC1(1), SOS1(6), STAT3(1)	9071948	61	50	60	18	18	18	18	3	4	0	0.53	1.00
200	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	3	GLS(2), GLUD1(3)	848170	5	5	5	1	1	2	1	0	1	0	0.54	1.00
201	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(4), HK2(6), HK3(7), IMPA1(1), PGM1(1), TGDS(1)	2756330	21	19	21	5	8	9	1	2	1	0	0.54	1.00
202	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(4), ESR1(6), ESR2(1), HNF4A(2), NR0B1(4), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(4), NR2F6(1), NR4A1(4), NR4A2(4), NR5A2(4), PGR(3), PPARA(2), PPARD(2), RARA(1), RARB(2), RARG(3), ROR1(4), RORA(3), RORC(3), RXRA(1), RXRG(5), THRA(2), THRB(1), VDR(3)	11522474	80	57	80	26	23	29	14	4	10	0	0.54	1.00
203	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(2), ANAPC1(4), ANAPC4(3), ANAPC5(3), ATM(7), ATR(11), BUB1(4), BUB1B(5), BUB3(1), CCNA1(1), CCNB1(1), CCNB3(9), CCND1(1), CCND2(3), CCND3(1), CCNE2(2), CDC25B(3), CDC25C(1), CDC27(3), CDC6(4), CDC7(1), CDK2(1), CDK7(1), CDKN2C(1), CDKN2D(1), CHEK1(4), CHEK2(3), CREBBP(12), CUL1(3), DBF4(4), E2F1(3), EP300(5), ESPL1(3), GADD45A(1), GADD45G(1), GSK3B(1), HDAC1(2), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(4), MCM5(6), MCM6(2), MCM7(3), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PKMYT1(1), PLK1(1), PRKDC(15), PTTG1(1), PTTG2(2), RB1(7), RBL1(6), RBL2(5), RBX1(1), SFN(2), SKP1(1), SKP2(1), SMAD2(2), SMAD4(2), SMC1A(2), SMC1B(5), TGFB1(1), TGFB2(1), WEE1(2), YWHAB(2), YWHAE(1), YWHAQ(1)	36875548	207	112	205	58	50	74	37	18	28	0	0.54	1.00
204	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(3), CPOX(3), EPRS(11), FECH(2), GUSB(3), HMBS(2), HMOX1(1), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1), UGT2B4(4), UROD(1)	7022990	45	39	45	10	9	20	11	2	3	0	0.54	1.00
205	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(1), TGFBR2(3), TGFBR3(6), TOB2(2)	2875946	17	17	17	8	0	8	6	0	3	0	0.55	1.00
206	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(6), ABCA10(8), ABCA12(7), ABCA13(27), ABCA2(6), ABCA3(3), ABCA4(12), ABCA5(3), ABCA6(6), ABCA7(4), ABCA8(5), ABCA9(8), ABCB10(6), ABCB11(6), ABCB4(9), ABCB5(7), ABCB6(4), ABCB7(2), ABCB8(1), ABCB9(4), ABCC1(4), ABCC10(4), ABCC11(5), ABCC12(12), ABCC2(4), ABCC3(2), ABCC4(1), ABCC5(7), ABCC6(3), ABCC8(5), ABCC9(9), ABCD1(3), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(8), CFTR(4), TAP1(2)	31347224	212	110	210	83	51	83	43	11	24	0	0.55	1.00
207	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), CREBBP(12), CTNNB1(3), DVL1(3), EP300(5), FZD1(1), GSK3B(1), HDAC1(2), LDB1(1), LEF1(3), PITX2(3), TRRAP(12)	8810288	55	46	54	19	10	18	17	3	7	0	0.55	1.00
208	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(1), AGPAT6(2), ENPP2(9), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLD1(10), PLD2(4), PPAP2B(2)	6299776	52	37	50	21	16	22	7	1	6	0	0.55	1.00
209	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(2), JUN(2), MAP2K1(2), MAPK1(1), MAPK3(2), MYC(1), NFKB1(2), PLCB1(7), PRKCA(5), RAF1(1), RELA(3)	4191188	31	25	31	10	10	10	3	6	2	0	0.55	1.00
210	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2R(2), F3(2), F5(15), FGA(5), FGB(3), FGG(1), SERPINC1(5)	4394464	36	26	36	8	5	15	13	2	1	0	0.56	1.00
211	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCNB1(1), CCND1(1), CCND2(3), CCND3(1), CDK2(1), CDK7(1), CDKN2C(1), CDKN2D(1), E2F1(3), RB1(7), RBL1(6)	4212192	27	23	27	6	4	9	4	3	7	0	0.56	1.00
212	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CDS1(2), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKI(7), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5D(6), INPP5E(2), INPPL1(3), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), OCRL(5), PI4KA(4), PI4KB(2), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3C3(3), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(1), PIP5K1C(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLCD3(2), PLCE1(10), PLCG1(2), PLCG2(3), PLCZ1(3), PRKCA(5), PRKCG(9), SYNJ1(2), SYNJ2(5)	33604442	215	107	214	75	70	68	37	15	25	0	0.57	1.00
213	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME2(2), ME3(2), PGK1(1), PKLR(3), PKM2(1), RPIA(1), TKT(1), TPI1(4)	4743700	30	28	28	12	8	12	4	2	4	0	0.57	1.00
214	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3D(1), CD80(2), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(2), PIK3R1(1), PTPN11(3)	2833226	16	16	16	7	2	7	3	2	2	0	0.57	1.00
215	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(2), F2RL3(2), GNAI1(2), GNB1(1), HRAS(2), ITGA1(4), ITGB1(4), MAP2K1(2), MAPK1(1), MAPK3(2), PLA2G4A(5), PLCB1(7), PRKCA(5), PTGS1(2), PTK2(3), RAF1(1), SYK(1), TBXAS1(5)	6603266	51	37	49	15	13	22	8	3	5	0	0.57	1.00
216	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(1), EPHB2(5), F2RL1(3), F2RL2(1), F2RL3(2), JUN(2), MAP2K5(2), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(3), PLD1(10), PLD2(4), PLD3(1), PTK2(3), RAF1(1), RASAL1(4), TEC(2), VAV1(7)	7510888	60	41	58	18	18	21	10	4	7	0	0.57	1.00
217	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(3), IL4(2), LTA(3), TGFB1(1), TGFB2(1)	3596846	21	20	21	7	3	6	5	3	4	0	0.58	1.00
218	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), AKT3(2), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), INPP5D(6), JAK1(1), JAK2(3), JAK3(7), NR0B2(1), PI3(1), PPP1R13B(4), RPS6KB1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(4), STAT6(1), TYK2(8)	9476898	59	48	59	17	8	23	15	4	9	0	0.58	1.00
219	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4)	4058222	22	20	22	11	7	2	7	1	5	0	0.58	1.00
220	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4)	4058222	22	20	22	11	7	2	7	1	5	0	0.58	1.00
221	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4)	4058222	22	20	22	11	7	2	7	1	5	0	0.58	1.00
222	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), AKAP1(3), AKAP11(7), AKAP12(4), AKAP3(6), AKAP5(1), AKAP6(12), AKAP7(2), AKAP8(3), AKAP9(6), ARHGEF1(2), CHMP1B(1), GNA12(1), GNA13(1), GNA14(1), GNA15(1), GNAI3(1), GNAL(2), GNAZ(2), GNB1(1), GNB2(3), GNB3(2), GNB5(1), GNG12(1), GNG3(1), GNG4(2), GNG5(1), HRAS(2), ITPR1(5), KRAS(1), PDE1A(2), PDE1B(1), PDE4B(3), PDE4C(4), PDE4D(1), PDE7B(1), PDE8A(6), PDE8B(2), PLCB3(4), PPP3CA(2), PPP3CC(2), PRKACA(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCI(4), PRKCQ(4), PRKD1(9), PRKD3(2), SLC9A1(3), USP5(3)	30555480	203	100	202	57	65	66	33	17	22	0	0.58	1.00
223	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ARPC1A(2), ARPC1B(1), CDC42(1), PAK1(3), PDGFRA(8), PIK3R1(1), RAC1(2), WASL(2)	2999656	21	19	21	7	7	7	4	3	0	0	0.59	1.00
224	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(1), AKT3(2), CASP9(1), CDC42(1), CHP(2), HRAS(2), KDR(11), KRAS(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPKAPK2(1), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NOS3(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLCG1(2), PLCG2(3), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCA(5), PRKCG(9), PTK2(3), PXN(3), RAC1(2), RAF1(1), SHC2(3), SPHK2(1)	19311932	134	80	134	51	40	45	15	19	15	0	0.59	1.00
225	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	IFNG(1), IFNGR1(3), JAK1(1), JAK2(3), PLA2G2A(1), PTPRU(8), STAT1(2)	3011048	19	18	18	3	4	9	4	0	2	0	0.60	1.00
226	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(7), CREB3(2), CREB5(3), DUSP4(1), DUSP6(1), DUSP9(4), EEF2K(3), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), MOS(4), NFKB1(2), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(6), SOS2(4), TRAF3(1)	8109146	53	44	52	15	10	15	17	2	9	0	0.60	1.00
227	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), ITGB1(4), KLRC1(1), KLRC3(1), LAT(1), MAP2K1(2), MAPK3(2), PAK1(3), PIK3R1(1), RAC1(2), SYK(1), VAV1(7)	4237290	26	24	26	8	9	6	5	4	2	0	0.60	1.00
228	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(1), HEXA(6), SLC33A1(3), ST3GAL1(1), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	3398732	22	21	21	10	7	8	4	0	3	0	0.60	1.00
229	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(2), FOS(1), HRAS(2), IGF1(2), IGF1R(1), IRS1(4), JUN(2), MAP2K1(2), MAPK3(2), MAPK8(2), PIK3R1(1), PTPN11(3), RAF1(1), RASA1(6), SHC1(1), SOS1(6), SRF(2)	6085998	40	35	40	7	12	13	6	4	5	0	0.61	1.00
230	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(7), PRKCA(5), RELA(3)	2235858	17	13	17	6	5	7	1	2	2	0	0.61	1.00
231	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), EGF(6), EGFR(9), FOS(1), HRAS(2), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(3), MAPK3(2), MAPK8(2), PIK3R1(1), PLCG1(2), PRKCA(5), RAF1(1), RASA1(6), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	9513210	61	48	60	14	18	20	10	4	9	0	0.61	1.00
232	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), BAAT(3), CEL(5), CYP27A1(2), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2)	6312592	44	36	42	13	9	21	6	4	4	0	0.61	1.00
233	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	19	ALDH18A1(4), ARG1(2), ASL(2), CKB(1), CKM(2), CKMT2(1), GATM(1), GLUD1(3), NAGS(1), ODC1(1), OTC(2), SMS(4)	3860642	24	21	24	6	4	10	5	0	5	0	0.62	1.00
234	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(5), IL4(2), MAF(1), MAP2K3(2), MAPK14(1), NFATC2(5), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	3260782	26	20	26	6	12	8	3	1	2	0	0.62	1.00
235	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	ABP1(6), ACAT1(1), ACMSD(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(11), CAT(1), CYP19A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(3), CYP2B6(3), CYP2C19(6), CYP2C8(3), CYP2C9(2), CYP2D6(3), CYP2E1(1), CYP2F1(4), CYP2J2(2), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(1), DDC(2), EHHADH(1), GCDH(1), HAAO(2), HADHA(2), KMO(3), KYNU(3), SDS(2), TDO2(1), TPH1(1), WARS(4), WARS2(1)	14418534	98	71	97	48	27	39	19	7	6	0	0.62	1.00
236	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(2), ALDOC(1), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK1(4), HK2(6), HK3(7), KHK(1), MPI(1), PFKFB1(3), PFKM(5), PFKP(2), PMM1(1), TPI1(4)	6506434	43	36	41	15	17	11	8	4	3	0	0.63	1.00
237	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), BPGM(2), DLAT(1), DLD(2), ENO2(2), ENO3(1), FBP2(1), G6PC(2), GAPDH(3), GCK(1), GPI(5), HK1(4), HK2(6), HK3(7), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(5), PFKP(2), PGK1(1), PGM1(1), PKLR(3), PKM2(1), TPI1(4)	12973530	88	66	85	22	28	38	11	6	5	0	0.63	1.00
238	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), BPGM(2), DLAT(1), DLD(2), ENO2(2), ENO3(1), FBP2(1), G6PC(2), GAPDH(3), GCK(1), GPI(5), HK1(4), HK2(6), HK3(7), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(5), PFKP(2), PGK1(1), PGM1(1), PKLR(3), PKM2(1), TPI1(4)	12973530	88	66	85	22	28	38	11	6	5	0	0.63	1.00
239	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(1), AKT3(2), BCL2L1(2), CDC42(1), CDK2(1), CREB3(2), CREB5(3), EBP(1), ERBB4(9), F2RL2(1), GAB1(2), GADD45A(1), GSK3A(4), GSK3B(1), IGF1(2), INPPL1(3), IRS1(4), IRS2(2), IRS4(3), MET(3), MYC(1), NOLC1(2), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PARD3(5), PARD6A(2), PDK1(1), PIK3CD(3), PPP1R13B(4), PREX1(12), PTK2(3), PTPN1(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(2), SOS1(6), SOS2(4), TSC1(6), TSC2(6), YWHAB(2), YWHAE(1), YWHAQ(1)	20089970	135	82	135	45	26	53	28	9	19	0	0.63	1.00
240	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(7), ATR(11), CDC25C(1), CHEK1(4), CHEK2(3)	4065520	26	22	26	1	6	6	5	5	4	0	0.63	1.00
241	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(7), CDC25B(3), CDC25C(1), CDK2(1), CHEK1(4), RB1(7), WEE1(2)	4531524	25	22	25	3	4	10	2	1	8	0	0.64	1.00
242	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), MTMR6(3), NFS1(3), TPK1(3)	1721082	11	11	11	3	2	4	4	0	1	0	0.64	1.00
243	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2A1(1), GTF2B(1), GTF2E1(1), HDAC3(1), NCOA1(6), NCOA2(10), NCOA3(4), NCOR2(6), POLR2A(2), RARA(1), RXRA(1), TBP(1)	6895008	37	34	37	18	8	15	5	2	7	0	0.64	1.00
244	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(9), CCND1(1), CD14(1), CTNNB1(3), DVL1(3), FZD1(1), GJA1(4), GNAI1(2), GSK3B(1), IRAK1(4), LBP(5), LEF1(3), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(3), TOLLIP(1)	7187818	46	37	46	10	9	14	11	5	7	0	0.64	1.00
245	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), E2F1(3), ETS1(2), ETV3(2), FOS(1), HDAC5(1), HRAS(2), JUN(2), NCOR2(6), RBL1(6), RBL2(5), SIN3A(5), SIN3B(3)	7269342	43	37	43	11	6	18	7	7	5	0	0.64	1.00
246	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(1), EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(9), FLT4(3), HIF1A(1), HRAS(2), KDR(11), NOS3(1), PIK3R1(1), PLCG1(2), PRKCA(5), PTK2(3), PXN(3), SHC1(1), VHL(1)	8685154	50	43	50	22	12	17	6	9	6	0	0.65	1.00
247	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(2), RDH11(2), RDH12(2), RDH13(1)	1309724	8	8	8	2	3	2	0	2	1	0	0.66	1.00
248	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(5), GCLC(2), GCLM(1), GGT1(2), GPX5(1), GPX6(2), GSR(2), GSS(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(2), OPLAH(3)	6086710	37	34	37	15	8	17	7	4	1	0	0.66	1.00
249	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(1), CALR(1), CANX(1), CD4(2), CD8B(1), CIITA(4), CTSL1(2), CTSS(2), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), HSP90AB1(2), HSPA5(2), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), KIR2DL1(3), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(1), LGMN(1), LTA(3), NFYB(1), PSME1(1), PSME2(1), RFX5(1), RFXAP(1), TAP1(2), TAPBP(3)	12369754	70	53	70	31	10	22	19	7	12	0	0.66	1.00
250	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(2), E2F1(3), MDM2(1), MYC(1), PIK3R1(1), POLR1A(4), POLR1B(4), POLR1C(1), POLR1D(1), RAC1(2), RB1(7), TBX2(3), TWIST1(1)	4540424	31	24	31	10	7	13	0	4	7	0	0.67	1.00
251	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(4), C5(1), C7(7), C8A(3), C9(2)	2928990	17	16	17	7	3	5	5	2	2	0	0.67	1.00
252	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(7), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(4)	3132622	18	18	18	7	4	4	8	0	2	0	0.67	1.00
253	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(6), ALDH3B2(2), AOC2(2), AOC3(3), DDC(2), EPX(5), GOT1(2), GOT2(3), HPD(3), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TAT(1)	5494504	36	32	35	19	11	13	9	3	0	0	0.67	1.00
254	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(2), FOS(1), JUN(2), MAPK3(2), OPRK1(1), POLR2A(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3)	3384492	20	19	20	6	6	8	1	2	3	0	0.67	1.00
255	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(4), C5(1), C7(7), ICAM1(2), ITGA4(5), ITGAL(1), ITGB1(4), ITGB2(3), SELP(8), SELPLG(1), VCAM1(4)	6211488	40	32	40	11	9	11	10	5	5	0	0.68	1.00
256	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(6), CARS(6), DARS(1), DARS2(5), EARS2(2), EPRS(11), FARS2(1), FARSA(2), GARS(1), HARS(2), HARS2(2), IARS(3), IARS2(4), KARS(3), LARS2(5), MARS(1), NARS(3), NARS2(2), PARS2(1), RARS(4), RARS2(2), SARS(2), SARS2(2), TARS(3), TARS2(2), VARS(4), VARS2(4), WARS(4), WARS2(1), YARS(1), YARS2(1)	14615580	93	66	93	32	15	40	24	5	9	0	0.68	1.00
257	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), FUT9(1), GBGT1(3), GLA(2), HEXA(6), NAGA(1), ST3GAL1(1), ST3GAL2(2), ST8SIA1(2)	2913504	19	17	18	7	2	12	2	2	1	0	0.68	1.00
258	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFB5(3), NDUFS1(4), NDUFV1(3), NDUFV2(2)	1823966	12	11	12	3	4	4	3	1	0	0	0.68	1.00
259	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), FOS(1), HRAS(2), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(3), MAPK3(2), MAPK8(2), PDGFRA(8), PIK3R1(1), PLCG1(2), PRKCA(5), RAF1(1), RASA1(6), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	8769348	54	44	54	19	18	15	10	5	6	0	0.68	1.00
260	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(4), PANK3(2), PANK4(1), PPCS(1)	3808488	29	22	29	10	8	12	4	2	3	0	0.68	1.00
261	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(3), ACVR1C(3), ACVR2A(3), ACVR2B(1), ACVRL1(3), AMHR2(4), BMP4(2), BMP5(5), BMP7(1), BMPR1A(3), CHRD(2), COMP(2), CREBBP(12), CUL1(3), DCN(1), EP300(5), GDF5(4), GDF6(2), ID4(1), IFNG(1), INHBA(4), INHBC(1), LEFTY2(2), LTBP1(10), MAPK1(1), MAPK3(2), MYC(1), NODAL(3), PITX2(3), PPP2R1A(6), PPP2R1B(2), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), RBL1(6), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), SKP1(1), SMAD1(3), SMAD2(2), SMAD4(2), SMAD7(1), SMURF1(4), SMURF2(1), SP1(1), TGFB1(1), TGFB2(1), TGFBR2(3), THBS1(1), THBS3(4), ZFYVE16(3), ZFYVE9(5)	26483908	155	93	154	48	28	55	32	19	21	0	0.68	1.00
262	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EGF(6), EGFR(9), TF(7), TFRC(2)	3479188	24	20	23	4	8	11	2	0	3	0	0.69	1.00
263	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(1), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(2), NFKB1(2), PIK3R1(1), RB1(7), RELA(3), SP1(1)	4701692	31	25	31	8	7	14	2	2	6	0	0.69	1.00
264	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(2), FOS(1), HRAS(2), JAK2(3), JUN(2), MAP2K1(2), MAPK3(2), MPL(3), PIK3R1(1), PLCG1(2), PRKCA(5), RAF1(1), RASA1(6), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2), THPO(1)	7485434	45	38	45	9	13	12	8	4	8	0	0.69	1.00
265	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(3), ATF2(2), EGFR(9), HRAS(2), JUN(2), MAP2K1(2), MAP2K2(2), MAP3K1(3), MAPK1(1), MAPK3(2), MAPK8(2), MEF2A(2), MEF2C(2), MEF2D(2), PAK1(3), PRKCA(5), PTK2(3), RAC1(2), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	9123746	61	48	60	23	19	19	12	6	5	0	0.69	1.00
266	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(5), BCAR1(5), CDC42(1), CDH5(2), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(2), CLDN9(3), CTNNB1(3), CTNND1(4), CYBB(6), ESAM(4), EZR(1), F11R(1), GNAI1(2), GNAI3(1), GRLF1(11), ICAM1(2), ITGA4(5), ITGAL(1), ITGAM(3), ITGB1(4), ITGB2(3), ITK(2), MAPK13(2), MAPK14(1), MLLT4(3), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYLPF(1), NCF2(5), NCF4(1), NOX1(2), NOX3(5), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(2), PLCG2(3), PRKCA(5), PRKCG(9), PTK2(3), PTPN11(3), PXN(3), RAC1(2), RAPGEF4(5), RASSF5(2), RHOH(3), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCAM1(4), VCL(2)	32525228	227	104	226	80	59	81	42	23	22	0	0.69	1.00
267	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(3), COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(4), ILVBL(2), PANK3(2), PANK4(1), PPCS(1), VNN1(2)	4731952	36	27	36	12	11	13	7	2	3	0	0.69	1.00
268	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	9	GPR37(2), SNCAIP(3), UBE2E2(1), UBE2G2(1), UBE2L6(1)	1465118	8	8	8	3	1	0	5	0	2	0	0.69	1.00
269	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MYC(1), SP1(1), SP3(1), WT1(4)	1666614	9	9	9	4	2	1	4	2	0	0	0.70	1.00
270	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), FOS(1), GNAI1(2), GNAS(4), GNB1(1), HRAS(2), JUN(2), MAP2K1(2), MAPK3(2), NFATC2(5), NFATC3(3), NFATC4(2), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), RAF1(1), RPS6KA3(1), SYT1(3)	9434534	65	49	65	21	22	22	7	9	5	0	0.70	1.00
271	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(1), ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(5), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(4), CREBBP(12), CSNK2A1(2), CTNNB1(3), CTNND1(4), EGFR(9), EP300(5), ERBB2(3), FARP2(6), FER(2), FGFR1(3), FYN(4), IGF1R(1), INSR(7), IQGAP1(6), LEF1(3), LMO7(7), MAP3K7(3), MAPK1(1), MAPK3(2), MET(3), MLLT4(3), NLK(2), PARD3(5), PTPN1(1), PTPRB(15), PTPRF(7), PTPRJ(3), PTPRM(6), PVRL1(3), PVRL3(2), PVRL4(5), RAC1(2), SMAD2(2), SMAD4(2), SNAI1(3), SNAI2(2), SORBS1(5), SSX2IP(1), TCF7(1), TGFBR2(3), TJP1(9), VCL(2), WAS(5), WASF3(1), WASL(2), YES1(1)	31278694	207	103	205	62	40	75	48	19	25	0	0.70	1.00
272	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(12), EP300(5), FADD(1), HDAC3(1), IKBKB(3), NFKB1(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6117860	34	29	33	10	7	10	6	4	7	0	0.71	1.00
273	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ACSS2(2), ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), ALDH1B1(3), ALDH2(2), ALDH3B2(2), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), BPGM(2), DLAT(1), DLD(2), ENO2(2), ENO3(1), FBP2(1), G6PC(2), G6PC2(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(5), HK1(4), HK2(6), HK3(7), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGK1(1), PGK2(5), PGM1(1), PKLR(3), PKM2(1), TPI1(4)	15403764	105	72	103	33	36	42	12	8	7	0	0.71	1.00
274	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(1), CDK2(1), CFL1(3), E2F1(3), MDM2(1), PRB1(2)	1870246	11	11	11	7	1	8	0	1	1	0	0.71	1.00
275	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CD3D(1), FOS(1), FYN(4), HRAS(2), JUN(2), LAT(1), LCK(2), MAP2K1(2), MAP3K1(3), MAPK3(2), MAPK8(2), NFATC2(5), NFATC3(3), NFATC4(2), NFKB1(2), PIK3R1(1), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKCA(5), RAC1(2), RAF1(1), RASA1(6), RELA(3), SHC1(1), SOS1(6), SYT1(3), VAV1(7), ZAP70(3)	12376696	83	58	83	19	24	25	12	13	9	0	0.71	1.00
276	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), GGPS1(1), IDI1(1), IDI2(1), SQLE(2)	1174622	7	7	7	0	2	3	1	1	0	0	0.71	1.00
277	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	506410	2	2	2	0	0	1	1	0	0	0	0.71	1.00
278	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(6), AOC2(2), AOC3(3), CES1(2), CES7(1), DDHD1(4), ESCO1(1), LIPA(2), MYST3(11), MYST4(3), PLA1A(5), PNPLA3(1), PRDX6(1), SH3GLB1(1)	6849084	45	37	45	21	12	18	7	4	4	0	0.72	1.00
279	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	303668	1	1	1	0	0	1	0	0	0	0	0.72	1.00
280	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(1), GALNT10(2), GALNT2(4), GALNT3(2), GALNT6(2), GALNT7(1), GALNT8(2), GCNT1(3), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2)	3526536	22	18	20	6	3	10	6	1	2	0	0.72	1.00
281	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(3), LEPR(10), PRKAA2(2), PRKAB2(1), PRKAG2(4)	3886986	24	23	24	7	8	8	6	1	1	0	0.72	1.00
282	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(2), B4GALT5(3), FUT8(2), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2)	2168218	13	13	12	10	3	6	2	1	1	0	0.72	1.00
283	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(5), ALG1(1), ALG13(8), ALG2(2), ALG6(3), B3GALT6(1), B3GNT2(1), B3GNT6(1), B3GNT7(2), B4GALT1(1), B4GALT3(2), B4GALT4(1), B4GALT5(3), C1GALT1C1(1), CHPF(1), CHST1(2), CHST11(1), CHST12(1), CHST14(1), CHST2(4), CHST3(2), CHST4(2), CHST6(3), EXT1(2), EXT2(1), EXTL1(2), EXTL3(1), FUT8(2), GALNT1(1), GALNT10(2), GALNT11(2), GALNT12(3), GALNT14(4), GALNT2(4), GALNT3(2), GALNT5(6), GALNT6(2), GALNT7(1), GALNT8(2), GALNTL1(3), GALNTL2(1), GALNTL4(4), GALNTL5(3), GANAB(5), GCNT1(3), GCNT3(3), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), MAN1A1(3), MAN1A2(4), MAN1C1(3), MAN2A1(4), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), NDST1(3), NDST2(1), NDST3(4), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(6), STT3B(1), XYLT1(4)	29176692	176	105	174	77	40	77	28	17	14	0	0.72	1.00
284	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3D(1), CD4(2)	675510	3	3	3	1	1	1	0	0	1	0	0.72	1.00
285	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(7), ATP4A(5), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(3), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX4I1(1), COX4I2(1), COX6B1(2), COX7A2(1), CYC1(4), NDUFA13(2), NDUFA6(2), NDUFA7(1), NDUFAB1(1), NDUFB5(3), NDUFB8(1), NDUFS1(4), NDUFS6(1), NDUFS8(1), NDUFV1(3), NDUFV2(2), SDHA(1), SDHC(1), UQCRB(1), UQCRC2(1)	15069124	87	64	86	31	21	29	22	6	9	0	0.72	1.00
286	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), AKT3(2), HRAS(2), MAP2K1(2), MAP2K2(2), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(6)	3889122	23	21	23	10	4	11	4	2	2	0	0.73	1.00
287	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G2(4), EIF4G3(3), GHR(2), IRS1(4), MAPK1(1), MAPK14(1), MAPK3(2), PABPC1(1), PDK2(2), PDPK1(1), PIK3R1(1), PRKCA(5), RPS6KB1(1)	6769340	43	36	43	18	7	20	9	3	4	0	0.73	1.00
288	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(1), JAK1(1), STAT1(2), STAT2(2), TYK2(8)	2905494	17	17	17	5	6	6	1	3	1	0	0.73	1.00
289	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), ALDOC(1), FBP2(1), GPI(5), H6PD(4), PFKM(5), PFKP(2), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TAL1(2), TALDO1(2), TKT(1)	5552176	33	29	32	14	11	10	3	3	6	0	0.73	1.00
290	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	9	ADH5(2), CAT(1), EPX(5), LPO(2), MPO(3), MTHFR(2), PRDX6(1)	2704176	16	16	16	9	3	6	6	1	0	0	0.73	1.00
291	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(3), CFLAR(1)	1038452	5	5	5	2	0	4	0	0	1	0	0.73	1.00
292	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(1), EGFR(9), IGF1R(1), MYC(1), POLR2A(2), PRKCA(5), RB1(7), TEP1(6), TERF1(2), TERT(5), TNKS(7), XRCC5(1)	7453394	47	35	46	13	9	20	5	3	10	0	0.73	1.00
293	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(6), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH3B2(2), ALDH9A1(2), AOC2(2), AOC3(3), ASPA(1), CNDP1(3), DDC(2), HARS(2), HDC(3), HNMT(1), PRPS1(1), PRPS2(1)	6575498	38	35	37	17	11	16	6	3	2	0	0.73	1.00
294	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(2), FYN(4), HLA-DRA(1), HLA-DRB1(1), LCK(2), PTPRC(3), ZAP70(3)	2464054	17	14	17	6	4	8	2	1	2	0	0.73	1.00
295	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(2), C1QB(2), C1R(2), C1S(4), C2(1), C3(4), C5(1), C7(7), C8A(3), C9(2)	4329494	28	23	28	12	6	11	6	2	3	0	0.73	1.00
296	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOA(1), ALDOB(2), ALDOC(1), FBP2(1), FPGT(2), FUK(1), GMPPA(1), HK1(4), HK2(6), HK3(7), KHK(1), MPI(1), MTMR1(1), MTMR2(1), MTMR6(3), PFKFB1(3), PFKFB2(1), PFKL(2), PFKM(5), PFKP(2), PGM2(5), PMM1(1), RDH11(2), RDH12(2), RDH13(1), TPI1(4)	10174124	62	51	60	18	22	16	10	7	7	0	0.74	1.00
297	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(9), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(1), RXRA(1), THRA(2), THRB(1)	4792828	32	25	31	10	11	12	4	0	5	0	0.74	1.00
298	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(5), CD79A(1), FOS(1), HRAS(2), JUN(2), LYN(1), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(2), MAPK8(2), NFATC2(5), NFATC3(3), NFATC4(2), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKCA(5), RAC1(2), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	10354616	70	52	70	22	21	20	12	10	7	0	0.74	1.00
299	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(1), NOTCH1(11), PSEN1(1)	2659320	14	12	14	6	2	5	0	1	6	0	0.75	1.00
300	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(3), MBTPS2(2), SCAP(4), SREBF1(3), SREBF2(2)	3331092	19	18	19	3	5	7	3	4	0	0	0.75	1.00
301	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS2(1), CDK5(2), CSNK1A1(1), GSK3B(1), MAPT(5)	2580466	13	13	13	5	2	5	0	1	5	0	0.75	1.00
302	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(3), JAK3(7), MAPK1(1), MAPK3(2), STAT3(1), TYK2(8)	3262918	23	18	23	4	5	12	4	1	1	0	0.75	1.00
303	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(1), ALDOB(2), ALDOC(1), DERA(1), FBP2(1), GPI(5), H6PD(4), PFKL(2), PFKM(5), PFKP(2), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TALDO1(2), TKT(1), TKTL1(4)	6312058	38	34	35	14	14	12	4	2	6	0	0.75	1.00
304	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(1), SQLE(2)	887152	5	5	5	0	2	2	0	1	0	0	0.75	1.00
305	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT6(2), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CEL(5), DAK(1), DGAT2(2), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKI(7), DGKZ(3), GK(4), GK2(5), GLA(2), GPAM(2), LIPA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), MGLL(1), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(2)	14585320	88	65	87	41	27	40	7	9	5	0	0.75	1.00
306	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(2), CRKL(1), DOCK1(3), FOS(1), GAB1(2), HGF(6), HRAS(2), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(2), MAP4K1(2), MAPK1(1), MAPK3(2), MAPK8(2), MET(3), PAK1(3), PIK3R1(1), PTK2(3), PTPN11(3), PXN(3), RAF1(1), RASA1(6), SOS1(6), STAT3(1)	11291786	68	51	68	26	18	22	11	7	10	0	0.75	1.00
307	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(3), LARS2(5), PDHA1(2), PDHA2(5)	2688156	16	15	16	3	2	8	4	1	1	0	0.75	1.00
308	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(4), BCMO1(1)	1037384	5	5	4	3	0	2	1	0	2	0	0.76	1.00
309	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(2), ENO3(1), FARS2(1), GOT1(2), GOT2(3), PAH(1), TAT(1), YARS(1)	2211650	12	12	11	5	5	4	1	1	1	0	0.76	1.00
310	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(4), HK2(6), HK3(7), IMPA1(1), PGM1(1), TGDS(1)	3175520	21	19	21	5	8	9	1	2	1	0	0.76	1.00
311	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACADS(3), ACAT1(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH5A1(1), ALDH9A1(2), EHHADH(1), GAD1(5), GAD2(5), HADHA(2), HMGCL(1), L2HGDH(1), OXCT1(2), PDHA1(2), PDHA2(5), SDS(2)	6966742	47	36	46	20	9	23	4	4	7	0	0.76	1.00
312	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1G(2), MEF2A(2), MEF2C(2), MEF2D(2)	1618376	8	8	8	7	3	1	1	2	1	0	0.76	1.00
313	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), AKR1B10(1), AKR1C4(1), AKR1D1(4), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BAAT(3), CEL(5), CYP27A1(2), CYP7A1(3), HADHB(2), LIPA(2), RDH11(2), RDH12(2), RDH13(1), SLC27A5(4), SOAT2(1), SRD5A1(2), SRD5A2(2)	8668778	60	45	59	16	16	26	6	7	5	0	0.76	1.00
314	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(2), AKT1(1), AKT3(2), APAF1(1), ATM(7), BAX(1), BCL2L1(2), BID(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(4), CASP6(1), CASP7(2), CASP8(1), CASP9(1), CFLAR(1), CHP(2), CHUK(2), CSF2RB(5), DFFA(1), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(3), IL1B(1), IL1RAP(2), IRAK1(4), IRAK2(1), IRAK3(3), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(3), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACA(1), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), RELA(3), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(2), TRADD(1)	21763526	127	80	127	49	38	45	10	17	17	0	0.76	1.00
315	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), CCND1(1), CCND2(3), CCND3(1), CTNNB1(3), DVL1(3), DVL3(3), FZD1(1), FZD10(2), FZD3(4), FZD6(1), FZD9(3), GSK3B(1), JUN(2), LDLR(4), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(7), PRKCA(5), PRKCD(2), PRKCE(5), PRKCG(9), PRKCH(1), PRKCI(4), PRKCQ(4), PRKD1(9), RAC1(2), SFRP4(3), TCF7(1), WNT10B(2), WNT11(2), WNT2(3), WNT2B(2), WNT3(2), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1)	16330076	117	72	117	34	36	44	21	10	6	0	0.77	1.00
316	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(5), ITGAL(1), ITGAM(3), ITGB1(4), ITGB2(3), SELE(4), SELL(2), SELP(8)	4718780	35	24	35	7	9	10	9	2	5	0	0.77	1.00
317	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(1), DHRS2(1), PON1(4), PON2(1), PON3(1), RDH11(2), RDH12(2), RDH13(1)	2268076	13	12	13	3	3	5	1	2	2	0	0.77	1.00
318	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	20	ASNS(3), CA12(2), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(1), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(3), GLUL(1)	4193680	21	21	21	2	5	8	6	0	2	0	0.77	1.00
319	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	B2M(1), CD3D(1), GZMB(1), ICAM1(2), ITGAL(1), ITGB2(3), PRF1(2)	2139916	11	11	11	6	2	4	2	2	1	0	0.78	1.00
320	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(7), CCND2(3), DAZL(1), DMC1(1), EGR1(4), ESR2(1), INHA(3), LHCGR(8), MLH1(3), MSH5(5), NCOR1(4), NRIP1(3), PGR(3), PRLR(5), PTGER2(1), SMPD1(3), VDR(3), ZP2(2)	9107726	60	46	58	24	24	17	6	6	7	0	0.78	1.00
321	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(1), HRAS(2), MAPK1(1), MAPK3(2), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(2), NTRK1(3), PIK3R1(1), PLCG1(2), RPS6KA1(4), SHC1(1)	4600410	24	24	24	11	7	9	3	3	2	0	0.78	1.00
322	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	12	ADH5(2), CAT(1), EPX(5), LPO(2), MPO(3), PRDX1(1), PRDX6(1)	2761848	15	15	15	10	3	4	7	1	0	0	0.78	1.00
323	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(1), APC(9), CAV3(1), DAG1(1), DLG4(1), EPHB2(5), GNAI1(2), ITPR1(5), ITPR2(11), ITPR3(3), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(3), PTX3(2), RAC1(2), RYR1(29)	12333620	80	58	80	22	21	31	14	6	8	0	0.78	1.00
324	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(2), FOS(1), HRAS(2), JUN(2), KLK2(1), MAP2K1(2), MAPK3(2), MAPK8(2), NGFR(1), PIK3R1(1), PLCG1(2), RAF1(1), SHC1(1), SOS1(6)	4595960	26	25	26	8	8	8	6	3	1	0	0.78	1.00
325	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(6), GGT1(2)	1569604	8	7	8	9	1	2	3	1	1	0	0.78	1.00
326	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB11(6), ABCB4(9), ABCC1(4), ABCC3(2)	3186912	21	18	21	7	11	5	3	1	1	0	0.78	1.00
327	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), JAK1(1), JAK2(3), TYK2(8)	2816850	15	15	15	6	3	6	4	1	1	0	0.79	1.00
328	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), JAK1(1), JAK2(3), TYK2(8)	2816850	15	15	15	6	3	6	4	1	1	0	0.79	1.00
329	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(5), CD19(2), CD22(5), CD81(1), CR2(9), DAG1(1), FLOT1(2), GSK3A(4), GSK3B(1), INPP5D(6), ITPR1(5), ITPR2(11), ITPR3(3), LYN(1), MAP4K1(2), MAPK1(1), MAPK3(2), NFATC2(5), NR0B2(1), PDK1(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), PPP3CA(2), PPP3CB(5), PPP3CC(2), PTPRC(3), RAF1(1), SHC1(1), SOS1(6), SOS2(4), SYK(1), VAV1(7)	19587120	116	74	116	45	32	36	18	12	18	0	0.79	1.00
330	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(2), PRKCA(5)	1819516	9	9	9	5	2	5	1	0	1	0	0.79	1.00
331	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(2), AGT(1), AKT1(1), CALR(1), CAMK1G(2), CAMK4(3), CREBBP(12), CSNK1A1(1), EDN1(1), ELSPBP1(1), FGF2(2), GSK3B(1), HAND1(1), HAND2(1), HRAS(2), IGF1(2), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(2), MAPK8(2), MEF2C(2), NFATC2(5), NFATC3(3), NFATC4(2), NKX2-5(2), PIK3R1(1), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), RAF1(1), RPS6KB1(1), SYT1(3)	11982604	81	55	81	32	24	25	10	13	9	0	0.79	1.00
332	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(12), EP300(5), IKBKB(3), IL1B(1), MAP2K3(2), MAP2K6(3), MAP3K14(1), MAP3K7(3), MAPK14(1), NFKB1(2), RELA(3), TGFBR2(3), TLR2(3)	8069630	44	39	42	14	11	15	7	3	8	0	0.79	1.00
333	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	JAK1(1), JAK2(3), JAK3(7), PIAS1(3), PIAS3(4), PTPRU(8)	3736754	26	21	24	4	5	14	4	1	2	0	0.79	1.00
334	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(2), ABL2(6), AKT1(1), AKT3(2), ARAF(3), AREG(2), BRAF(7), CAMK2B(2), CAMK2D(1), CBL(4), CBLB(4), CRKL(1), EGF(6), EGFR(9), ERBB2(3), ERBB3(3), ERBB4(9), EREG(1), GAB1(2), GSK3B(1), HBEGF(1), HRAS(2), JUN(2), KRAS(1), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MYC(1), NCK1(3), NRG1(4), NRG2(2), NRG3(5), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(2), PLCG2(3), PRKCA(5), PRKCG(9), PTK2(3), RAF1(1), RPS6KB1(1), SHC1(1), SHC2(3), SHC3(3), SHC4(4), SOS1(6), SOS2(4), STAT5A(2), TGFA(1)	27584304	186	96	185	69	50	69	31	13	23	0	0.79	1.00
335	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	8	ADAR(7), APOBEC2(1), APOBEC3F(2), APOBEC4(2)	1832866	12	10	12	3	5	3	1	1	2	0	0.79	1.00
336	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1)	817376	3	3	3	2	0	1	0	0	2	0	0.79	1.00
337	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(3), CD3D(1), CD4(2), CD58(1)	1701146	8	8	8	7	3	3	0	0	2	0	0.80	1.00
338	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(1), BCL2L1(2), CASP9(1), CDC42(1), CHUK(2), H2AFX(1), HRAS(2), MAP2K1(2), MAPK3(2), NFKB1(2), PIK3R1(1), RAC1(2), RAF1(1), RALA(2), RALBP1(1), RALGDS(1), RELA(3)	4640638	27	24	27	8	7	9	2	6	3	0	0.80	1.00
339	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	22	ASNS(3), CA12(2), CA13(1), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(1), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(3), GLUL(1)	4508384	22	22	22	4	5	9	6	0	2	0	0.80	1.00
340	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT3(2), APC(9), CSNK1A1(1), CTNNB1(3), DACT1(4), DKK1(3), DKK2(1), DKK4(1), DVL1(3), FSTL1(2), GSK3A(4), GSK3B(1), LRP1(14), MVP(3), NKD1(1), NKD2(2), PSEN1(1), SENP2(3), SFRP1(1), WIF1(4)	10938100	64	51	63	21	18	21	13	2	10	0	0.80	1.00
341	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(5), GNAI1(2), GNB1(1), HRAS(2), MAP2K1(2), MAPK1(1), MAPK3(2), NFKB1(2), PIK3C2G(7), PIK3R1(1), PLCG1(2), PRKCA(5), PTK2(3), PXN(3), RAF1(1), RELA(3)	6906222	42	35	42	17	12	17	5	5	3	0	0.80	1.00
342	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2), SNAP25(2)	869530	4	4	4	6	1	2	1	0	0	0	0.80	1.00
343	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(6), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2)	1973842	12	11	12	6	4	6	1	1	0	0	0.80	1.00
344	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(5), AMY2B(5), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(2), DDX23(6), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(7), ENPP3(4), ENTPD7(1), ERCC2(3), ERCC3(2), G6PC(2), G6PC2(2), GANC(3), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(3), GYS1(1), GYS2(3), HK1(4), HK2(6), HK3(7), IFIH1(3), MGAM(5), NUDT8(1), PGM1(1), PYGB(2), PYGM(6), RAD54L(1), SETX(11), SKIV2L2(2), SMARCA2(3), TREH(1), UGDH(3), UGP2(5), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UXS1(3)	32156056	181	101	180	56	52	69	36	10	14	0	0.81	1.00
345	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(5), GCLC(2), GCLM(1), GGT1(2), GPX5(1), GSS(2), GSTA2(1), GSTA4(2), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(2)	4947866	28	27	28	13	8	13	4	3	0	0	0.81	1.00
346	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(1), ATM(7), ATR(11), BAI1(8), BAX(1), BID(1), CASP8(1), CASP9(1), CCNB1(1), CCNB3(9), CCND1(1), CCND2(3), CCND3(1), CCNE2(2), CCNG1(1), CD82(1), CDK2(1), CHEK1(4), CHEK2(3), DDB2(4), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(2), IGF1(2), IGFBP3(1), MDM2(1), PPM1D(1), RFWD2(4), RPRM(1), RRM2B(2), SERPINB5(2), SERPINE1(2), SESN1(3), SESN2(3), SESN3(2), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TSC2(6)	17264754	105	67	104	29	18	39	19	12	17	0	0.81	1.00
347	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ARSD(1), ARSE(2), B4GALT6(2), CERK(3), ENPP7(4), GAL3ST1(1), GALC(2), GLA(2), NEU1(4), NEU2(2), NEU3(2), PPAP2B(2), SGMS1(2), SGMS2(1), SGPP1(2), SMPD1(3), SMPD2(2), SMPD3(3), SPHK2(1), SPTLC2(3), UGT8(6)	8350870	50	40	50	17	13	18	10	5	4	0	0.81	1.00
348	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2)	2153800	11	11	10	0	1	7	1	1	1	0	0.81	1.00
349	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2)	2153800	11	11	10	0	1	7	1	1	1	0	0.81	1.00
350	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(1), ALOX15(2), ALOX15B(1), CYP2B6(3), CYP2C19(6), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2J2(2), CYP4A22(1), CYP4F2(3), CYP4F3(3), EPHX2(2), GGT1(2), GPX5(1), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PTGES(1), PTGS1(2), TBXAS1(5)	10638882	66	50	64	32	18	18	19	3	8	0	0.81	1.00
351	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(7), ATR(11), BRCA1(6), CCNB1(1), CDC25B(3), CDC25C(1), CDKN2D(1), CHEK1(4), CHEK2(3), EP300(5), GADD45A(1), MDM2(1), PRKDC(15), RPS6KA1(4), WEE1(2), YWHAQ(1)	11367080	66	52	64	8	15	22	13	9	7	0	0.82	1.00
352	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(1), AKT3(2), CARD11(3), CBL(4), CBLB(4), CD3D(1), CD4(2), CD40LG(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), FOS(1), FYN(4), GRAP2(1), HRAS(2), ICOS(2), IFNG(1), IKBKB(3), IL10(1), IL4(2), ITK(2), JUN(2), KRAS(1), LAT(1), LCK(2), LCP2(2), MALT1(2), MAP3K14(1), NCK1(3), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PDK1(1), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCQ(4), PTPRC(3), RASGRP1(1), SOS1(6), SOS2(4), TEC(2), VAV1(7), VAV2(4), VAV3(1), ZAP70(3)	27075046	164	92	164	53	43	52	28	20	21	0	0.82	1.00
353	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(1), ARPC1A(2), ARPC1B(1), NCK1(3), NCKAP1(5), NTRK1(3), RAC1(2), WASF3(1), WASL(2)	4129422	22	21	22	15	3	11	2	2	4	0	0.82	1.00
354	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(1), CCND1(1), CDK2(1), E2F1(3), HRAS(2), MAPK1(1), MAPK3(2), NFKB1(2), PAK1(3), PIK3R1(1), RAC1(2), RAF1(1), RB1(7), RELA(3)	4943950	30	24	30	5	6	12	1	4	7	0	0.82	1.00
355	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(2), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(1)	2415104	14	12	14	5	2	7	2	1	2	0	0.82	1.00
356	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(8), ARHGEF1(2), F2R(2), F2RL3(2), GNA12(1), GNA13(1), GNAI1(2), GNB1(1), MAP3K7(3), PIK3R1(1), PLCB1(7), PPP1R12B(3), PRKCA(5), ROCK1(5)	6447694	43	34	43	11	11	19	7	4	2	0	0.82	1.00
357	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), CBS(4), MUT(1)	1333932	7	6	7	1	0	5	0	0	2	0	0.82	1.00
358	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(2), IKBKB(3), LTA(3), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TANK(4), TNFAIP3(4), TNFRSF1B(1), TRAF1(4), TRAF3(1)	6090804	33	26	33	14	5	9	6	5	8	0	0.82	1.00
359	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(5), FCER1A(1), FOS(1), HRAS(2), JUN(2), LYN(1), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(2), MAPK8(2), NFATC2(5), NFATC3(3), NFATC4(2), PAK2(1), PIK3R1(1), PLA2G4A(5), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	11048638	69	53	69	29	20	20	12	11	6	0	0.82	1.00
360	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(7), BAX(1), CCND1(1), CDK2(1), E2F1(3), GADD45A(1), MDM2(1), RB1(7)	4723408	23	21	23	4	3	9	2	2	7	0	0.82	1.00
361	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2)	1501074	7	7	7	4	3	4	0	0	0	0	0.83	1.00
362	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1), OXCT1(2)	901926	4	4	4	3	3	1	0	0	0	0	0.83	1.00
363	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(2), CPO(1), FECH(2), GATA1(3), HBB(2), HMBS(2), UROD(1)	2209870	13	12	13	3	4	6	0	1	2	0	0.83	1.00
364	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), GOT1(2), GOT2(3), PAH(1), TAT(1), YARS(1), YARS2(1)	2348888	12	12	11	8	6	4	0	1	1	0	0.83	1.00
365	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(2), FUT3(3), ST3GAL4(2)	1955330	9	9	9	5	3	0	5	1	0	0	0.83	1.00
366	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB4A(3)	1158068	5	5	5	10	3	2	0	0	0	0	0.83	1.00
367	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(7), BUB1(4), BUB1B(5), BUB3(1), CCNA1(1), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDAN1(3), CDC25B(3), CDC25C(1), CDC6(4), CDC7(1), CDH1(4), CDK2(1), CHEK1(4), CHEK2(3), DTX4(2), E2F1(3), EP300(5), ESPL1(3), GADD45A(1), GSK3B(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(4), MCM5(6), MCM6(2), MCM7(3), MDM2(1), MPEG1(5), MPL(3), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PLK1(1), PRKDC(15), PTTG1(1), PTTG2(2), RB1(7), RBL1(6), SKP2(1), SMAD4(2), TBC1D8(2), TGFB1(1), WEE1(2)	29837428	161	96	159	50	34	62	30	11	24	0	0.83	1.00
368	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(6), MAP2(9), PPP1CA(1), PRKACB(2), PRKACG(1), PRKAR2B(3), PRKCE(5)	4900162	27	24	27	11	8	5	9	3	2	0	0.83	1.00
369	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	244	ACVR1B(3), ACVR2A(3), ACVR2B(1), AMHR2(4), BMP7(1), BMPR1A(3), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL3(2), CCR1(2), CCR3(1), CCR4(3), CCR6(2), CCR8(3), CD27(2), CD40(1), CD40LG(2), CNTFR(1), CSF1(2), CSF1R(3), CSF2RB(5), CSF3R(5), CX3CR1(3), CXCL5(2), CXCR3(1), EDA2R(1), EGF(6), EGFR(9), EPOR(2), FAS(1), FASLG(1), FLT1(9), FLT3(4), FLT4(3), GDF5(4), GH1(1), GH2(2), GHR(2), HGF(6), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL10RA(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL17A(1), IL17RA(3), IL17RB(2), IL18R1(2), IL18RAP(2), IL1B(1), IL1R2(3), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(1), IL26(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL5RA(2), IL6R(1), IL7R(3), INHBA(4), INHBC(1), KDR(11), KIT(6), LEPR(10), LIFR(4), LTA(3), LTB(1), LTBR(1), MET(3), MPL(3), NGFR(1), OSMR(4), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(5), PF4(1), PLEKHO2(5), PRL(1), PRLR(5), TGFB1(1), TGFB2(1), TGFBR2(3), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF13B(2), TNFRSF14(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(2), TNFSF18(1), VEGFC(4), XCL1(1), XCR1(1)	46629236	297	120	295	134	81	110	52	18	36	0	0.84	1.00
370	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(1), AKT3(2), BCR(1), BTK(5), CD19(2), FLOT1(2), GAB1(2), ITPR1(5), ITPR2(11), ITPR3(3), LYN(1), NR0B2(1), PDK1(1), PHF11(2), PITX2(3), PLCG2(3), PPP1R13B(4), PREX1(12), PTPRC(3), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(2), VAV1(7)	14183574	82	60	82	37	20	29	13	7	13	0	0.84	1.00
371	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(4), CAMK2B(2), CAMK2D(1), CDK5(2), FYN(4), GNAI1(2), GNB1(1), HRAS(2), JAK2(3), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK14(1), MAPK3(2), MAPK8(2), MAPT(5), MYLK(7), PLCG1(2), PRKCA(5), RAF1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2), SYT1(3)	11315994	67	54	67	20	14	28	13	5	7	0	0.84	1.00
372	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(2), FUCA1(1), HEXA(6), MAN2C1(5), MANBA(2), NEU1(4), NEU2(2), NEU3(2)	3513542	24	17	24	6	4	11	7	0	2	0	0.84	1.00
373	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B10(1), B4GALT1(1), G6PC(2), G6PC2(2), GALE(1), GALK2(1), GALT(1), GANC(3), GCK(1), GLA(2), HK1(4), HK2(6), HK3(7), MGAM(5), PFKL(2), PFKM(5), PFKP(2), PGM1(1), RDH11(2), RDH12(2), RDH13(1), UGP2(5)	9542224	57	48	56	20	21	22	4	6	4	0	0.84	1.00
374	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(9), ATF2(2), BMP10(1), BMP4(2), BMP5(5), BMP7(1), BMPR1A(3), CHRD(2), CTNNB1(3), DVL1(3), FZD1(1), GSK3B(1), MAP3K7(3), MEF2C(2), MYL2(1), NKX2-5(2), RFC1(1), TGFB1(1), TGFB2(1), TGFBR2(3), TGFBR3(6)	9785906	53	43	53	18	10	16	14	7	6	0	0.84	1.00
375	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(2), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	2378792	11	11	11	4	1	7	1	1	1	0	0.84	1.00
376	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(5), CD19(2), DAG1(1), EPHB2(5), ITPKA(1), ITPKB(3), LYN(1), MAP2K1(2), MAP2K2(2), MAPK1(1), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), PI3(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), RAF1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(4), SYK(1), VAV1(7)	13747830	78	56	78	31	17	26	15	9	11	0	0.84	1.00
377	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	30	ACP1(1), ACPT(2), ALPI(1), ALPL(3), ALPP(1), ALPPL2(1), CYP19A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(3), CYP2B6(3), CYP2C19(6), CYP2C8(3), CYP2C9(2), CYP2D6(3), CYP2E1(1), CYP2F1(4), CYP2J2(2), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(1), PON1(4)	7658806	52	39	52	28	20	13	13	3	3	0	0.85	1.00
378	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	49	ALG6(3), CCKBR(1), CCR3(1), CELSR1(10), CELSR2(7), CELSR3(9), CHRM2(6), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(2), EMR2(5), EMR3(3), F2R(2), GHRHR(3), GPR116(4), GPR132(1), GPR133(2), GPR143(2), GPR17(5), GPR18(1), GPR55(1), GPR56(1), GPR61(2), GPR77(4), GPR84(1), GRPR(2), HRH4(3), LGR6(2), LPHN2(6), LTB4R2(1), NTSR1(3), OR8G2(1), P2RY13(1), PTGFR(2), SMO(1), SSTR2(2), TAAR5(5), TSHR(1), VN1R1(2)	16444886	115	68	115	52	36	40	21	5	13	0	0.85	1.00
379	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), FOS(1), HRAS(2), JAK2(3), MAP2K1(2), MAPK3(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	4575846	25	24	25	5	7	9	5	1	3	0	0.85	1.00
380	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AGPAT3(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), CEL(5), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKZ(3), GK(4), GLA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(2)	11725394	66	53	64	32	18	33	5	5	5	0	0.85	1.00
381	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT3(1), CDS1(2), CHAT(2), CHKA(2), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKZ(3), ETNK1(3), GPD1(2), GPD2(2), LYPLA1(5), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLCB2(5), PLCG1(2), PLCG2(3), PPAP2B(2)	13840390	80	60	80	34	22	32	13	5	8	0	0.85	1.00
382	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	1626208	8	8	8	3	3	2	2	0	1	0	0.85	1.00
383	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(9), BTRC(1), CTNNB1(3), DLL1(1), DVL1(3), FZD1(1), GSK3B(1), NOTCH1(11), PSEN1(1)	5808318	31	27	31	8	6	11	5	1	8	0	0.85	1.00
384	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(2), HRAS(2), INSR(7), IRS1(4), JAK2(3), MAP2K1(2), MAPK1(1), MAPK3(2), PIK3R1(1), PLCG1(2), PRKCA(5), RAF1(1), RPS6KA1(4), SHC1(1), SLC2A4(2), SOS1(6), SRF(2), STAT5A(2)	8349802	50	41	50	15	10	21	11	4	4	0	0.85	1.00
385	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(6), ACAT1(1), AKR1B10(1), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), EHHADH(1), EHMT2(2), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), NSD1(11), OGDH(3), OGDHL(4), PIPOX(1), PLOD1(2), PLOD2(4), PLOD3(4), RDH11(2), RDH12(2), RDH13(1), SETD1A(6), SETDB1(5), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(2)	15838974	85	64	85	46	12	30	21	8	14	0	0.85	1.00
386	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADL(2), ACADM(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL5(1), ACSL6(2), ADIPOQ(1), ANGPTL4(1), APOA2(1), APOA5(3), AQP7(2), CD36(1), CPT1A(3), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A22(1), CYP7A1(3), DBI(1), EHHADH(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(5), HMGCS2(1), ILK(1), LPL(3), MMP1(3), NR1H3(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(2), PPARA(2), PPARD(2), RXRA(1), RXRG(5), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(2), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(1), UCP1(2)	17498112	103	71	103	54	26	36	26	6	9	0	0.86	1.00
387	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(3), STAT1(2)	2203818	11	10	11	2	2	4	4	0	1	0	0.86	1.00
388	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(1), BRAF(7), CREB3(2), CREB5(3), CREBBP(12), CRKL(1), DAG1(1), EGR1(4), EGR2(6), EGR3(1), FRS2(3), JUN(2), MAP1B(4), MAPK1(1), MAPK10(1), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3C2G(7), PIK3CD(3), PIK3R1(1), PTPN11(3), RPS6KA3(1), SHC1(1), TH(2)	13677876	85	61	84	34	29	30	14	6	6	0	0.87	1.00
389	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(4), CD3D(1), DAG1(1), EPHB2(5), GRAP2(1), ITK(2), ITPKA(1), ITPKB(3), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(3), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PLCG1(2), PTPRC(3), RAF1(1), RASGRP1(1), RASGRP3(8), RASGRP4(4), SOS1(6), SOS2(4), VAV1(7), ZAP70(3)	14819924	94	64	94	32	28	33	18	5	10	0	0.87	1.00
390	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), CERK(3), CREB3(2), CREB5(3), DAG1(1), EPHB2(5), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1)	7865998	43	37	43	11	11	15	10	2	5	0	0.87	1.00
391	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(3), ACADS(3), ACAT1(1), ACSM1(6), AKR1B10(1), ALDH1B1(3), ALDH2(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(6), DDHD1(4), EHHADH(1), GAD1(5), GAD2(5), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), L2HGDH(1), OXCT1(2), PDHA1(2), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(2), RDH12(2), RDH13(1)	11071778	78	49	78	30	18	33	8	10	9	0	0.87	1.00
392	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB6(1), PSMC3(1), PSMD14(3), RPN1(1), UBE2A(2), UBE3A(4)	3479544	17	17	17	6	4	8	3	0	2	0	0.87	1.00
393	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), HTR2C(3), PLCB1(7)	1924358	11	10	11	5	4	5	0	2	0	0	0.87	1.00
394	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), MECR(1), PPT1(1), PPT2(1)	2306524	10	10	10	2	2	1	2	3	2	0	0.88	1.00
395	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(6), ACY3(2), ALDH1B1(3), ALDH2(2), ALDH3B2(2), ALDH7A1(1), ALDH9A1(2), AMDHD1(2), AOC2(2), AOC3(3), ASPA(1), CARM1(1), CNDP1(3), DDC(2), HARS(2), HARS2(2), HDC(3), HNMT(1), LCMT1(2), LCMT2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), PRPS1(1), PRPS2(1), UROC1(3), WBSCR22(4)	10716134	61	50	61	24	23	22	8	4	4	0	0.88	1.00
396	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(5), ITGAL(1), ITGB1(4), ITGB2(3), SELE(4), SELL(2)	3655764	24	17	24	3	6	7	7	2	2	0	0.88	1.00
397	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), BCL2A1(1), BCL2L1(2), CASP1(2), CASP10(4), CASP2(1), CASP4(3), CASP6(1), CASP7(2), CASP8(1), CASP9(1), CD40(1), CD40LG(2), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(3), MCL1(2), NFKB1(2), NGFR(1), NTRK1(3), PTPN13(3), SFRS2IP(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(1), TRAF6(1)	12079436	63	49	63	27	14	24	6	7	12	0	0.88	1.00
398	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(1), ARPC1A(2), ARPC1B(1), CDC42(1), RAC1(2), WASL(2)	2180856	11	11	11	7	1	7	2	1	0	0	0.88	1.00
399	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(2), B4GALT4(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GCNT2(1), ST3GAL6(1), ST8SIA1(2)	4446796	24	20	24	19	8	7	6	2	1	0	0.88	1.00
400	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(2), GNS(1), GUSB(3), HEXA(6), IDS(1), IDUA(2)	2919378	15	13	15	2	2	6	3	1	3	0	0.88	1.00
401	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(1), ACADS(3), ACAT1(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH6A1(2), ALDH9A1(2), AOX1(11), BCAT1(1), BCKDHB(2), EHHADH(1), HADHA(2), HADHB(2), HMGCL(1), MCCC1(7), MUT(1), OXCT1(2), PCCA(2), PCCB(6), SDS(2)	9687116	61	43	60	19	9	25	12	8	7	0	0.88	1.00
402	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(1), ADH5(2), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHB(2), LDHC(1), LDHD(6), MDH1(1), MDH2(1), ME2(2), ME3(2), PC(4), PCK1(3), PDHA1(2), PDHA2(5), PKLR(3), PKM2(1)	9947530	56	46	55	21	12	28	6	4	6	0	0.88	1.00
403	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(5), CAMK2B(2), CAMK4(3), CNR1(3), CREBBP(12), CSNK2A1(2), EGR2(6), EGR3(1), EP300(5), FCER1A(1), FCGR3A(3), FKBP1B(1), FOS(1), GATA3(5), GRLF1(11), GSK3A(4), GSK3B(1), HRAS(2), ICOS(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL1B(1), IL4(2), ITK(2), KPNA5(2), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(3), NFAT5(3), NFATC2(5), NFATC3(3), NFATC4(2), NFKB2(2), NFKBIB(1), NUP214(5), OPRD1(2), P2RX7(1), PAK1(3), PPP3CB(5), PPP3CC(2), PPP3R1(1), PTPRC(3), RELA(3), SFN(2), SLA(2), SP1(1), SP3(1), TGFB1(1), TRPV6(5), VAV1(7), VAV2(4), VAV3(1), XPO5(3)	24820854	161	87	160	55	50	46	28	17	20	0	0.88	1.00
404	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), CSF1(2), FCGR3A(3), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(1), TNFRSF1A(2), TNFRSF1B(1)	3779118	21	17	21	9	6	5	5	2	3	0	0.88	1.00
405	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(3), CASP10(4), CASP7(2), CASP8(1), CASP9(1), DFFA(1), DFFB(2), GZMB(1), PRF1(2), SCAP(4), SREBF1(3), SREBF2(2)	5027432	27	24	27	11	7	11	4	3	2	0	0.88	1.00
406	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD4(2), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	3034544	15	15	15	8	3	8	1	2	1	0	0.89	1.00
407	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(2), IDH3B(3), MDH1(1), MDH2(1), OGDH(3), PC(4), PDHA1(2), PDHA2(5), PDK1(1), PDK2(2), PDK3(2), PDK4(2), PDP2(4), SDHA(1), SDHC(1), SUCLA2(2), SUCLG2(1)	7678564	45	36	45	16	5	21	7	6	6	0	0.89	1.00
408	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(24), B3GALT4(1), CDR1(2), DGKI(7), MRPL19(1), PIGK(1), RPL14(1), RPL19(1), RPL28(1), RPL30(1), RPL32(1), RPL37(1), RPL3L(1), RPL4(1), RPL5(2), RPL7(1), RPL8(4), RPLP0(2), RPS11(1), RPS18(2), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3), RPS6KB1(1), RPS8(1), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1)	14395750	77	62	77	43	22	21	22	10	2	0	0.89	1.00
409	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(3), RXRA(1)	1557322	7	7	7	4	2	4	0	1	0	0	0.89	1.00
410	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5E(2), INPPL1(3), IPMK(1), ITPKA(1), ITPKB(3), OCRL(5), PI4KA(4), PI4KB(2), PIK3C3(3), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIP4K2A(2), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(1), PIP5K1C(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), PLCD3(2), PLCE1(10), PLCG1(2), PLCG2(3), PLCZ1(3), SYNJ1(2), SYNJ2(5)	19558106	119	75	118	43	38	38	20	10	13	0	0.89	1.00
411	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(2), CPOX(3), FECH(2), HMBS(2), PPOX(1), UROD(1)	2065156	11	10	11	1	2	7	0	1	1	0	0.89	1.00
412	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	GORASP1(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1), MAPKAPK5(4), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), PIK3CD(3), PIK3R1(1), SYT1(3), TRAF3(1), TRAF5(2), TRAF6(1)	8770594	45	38	45	12	13	16	3	7	6	0	0.89	1.00
413	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTR2(1), AKT1(1), CDC42(1), CFL1(3), CFL2(1), FLNA(9), FLNC(13), FSCN3(1), GDI1(2), GDI2(1), LIMK1(1), MYLK(7), MYLK2(2), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), ROCK1(5), ROCK2(3), VASP(2), WASL(2)	11843586	69	53	69	31	16	32	11	3	7	0	0.89	1.00
414	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	B4GALT1(1), FBP2(1), G6PC(2), GALE(1), GALK2(1), GALT(1), GANAB(5), GCK(1), GLA(2), HK1(4), HK2(6), HK3(7), MGAM(5), PFKM(5), PFKP(2), PGM1(1)	7869914	45	39	44	19	16	21	2	4	2	0	0.89	1.00
415	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(6), ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), ALDH3B2(2), AOC2(2), AOC3(3), AOX1(11), CARM1(1), DBH(2), DCT(1), DDC(2), ECH1(1), ESCO1(1), FAH(1), GOT1(2), GOT2(3), GSTZ1(2), HPD(3), LCMT1(2), LCMT2(1), MYST3(11), MYST4(3), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), SH3GLB1(1), TAT(1), TH(2), TYR(3), TYRP1(2), WBSCR22(4)	15374572	94	65	93	30	28	39	9	10	8	0	0.89	1.00
416	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), EGR2(6), EGR3(1), MAP3K1(3), MYC(1), NFATC2(5), NFKB1(2), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), RELA(3), SYT1(3), VIP(2)	7466566	49	34	49	15	16	14	5	8	6	0	0.89	1.00
417	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(1), ITGAM(3), ITGB2(3), SELE(4), SELL(2)	3233726	18	16	18	5	5	5	5	2	1	0	0.89	1.00
418	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(5), CAMK2B(2), CAMK2D(1), CLCA1(6), CLCA2(3), CLCA4(2), CNGA3(3), CNGA4(5), CNGB1(5), GNAL(2), GUCA1A(2), PRKACA(1), PRKACB(2), PRKACG(1), PRKG1(5), PRKG2(5), PRKX(1)	7900530	51	38	51	13	18	16	5	5	7	0	0.89	1.00
419	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADCY9(4), CAMK2B(2), CAMK2D(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(12), CTNNB1(3), DCT(1), DVL1(3), DVL3(3), EDN1(1), EDNRB(5), EP300(5), FZD1(1), FZD10(2), FZD3(4), FZD4(1), FZD6(1), FZD9(3), GNAI1(2), GNAI3(1), GNAS(4), GSK3B(1), HRAS(2), KIT(6), KRAS(1), LEF1(3), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), POMC(2), PRKACA(1), PRKACB(2), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), TCF7(1), TYR(3), TYRP1(2), WNT10B(2), WNT11(2), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(2)	29302182	193	97	192	69	59	73	30	17	14	0	0.89	1.00
420	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ7(2), NDUFA13(2)	1115170	6	6	6	2	2	3	1	0	0	0	0.90	1.00
421	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(1), APC(9), AR(4), BRAF(7), CCL16(1), DAG1(1), EGFR(9), GNA15(1), GNAI1(2), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CD(3), PIK3R1(1), PITX2(3), PTX3(2), RAF1(1)	13775954	79	59	78	24	23	27	16	5	8	0	0.90	1.00
422	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CCND1(1), CREBBP(12), EP300(5), ERCC3(2), ESR1(6), GRIP1(5), GTF2A1(1), GTF2E1(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MEF2C(2), NCOR2(6), NR0B1(4), NRIP1(3), PELP1(1), POLR2A(2), TBP(1)	12822586	68	54	67	24	20	19	13	7	9	0	0.90	1.00
423	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	AGA(2), ARSB(2), FUCA1(1), GNS(1), GUSB(3), HEXA(6), HGSNAT(2), HPSE(3), HPSE2(4), HYAL1(4), IDS(1), IDUA(2), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(4), NEU2(2), NEU3(2), SPAM1(3)	8481878	53	36	52	14	7	24	14	1	7	0	0.90	1.00
424	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(2), MDH1(1), OGDH(3), SDHA(1), SUCLA2(2)	2517098	11	11	11	8	0	5	2	3	1	0	0.90	1.00
425	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	IL6R(1), JAK1(1), JAK2(3), JAK3(7), PIAS3(4), PTPRU(8), STAT3(1)	4136186	25	21	23	4	6	13	3	1	2	0	0.90	1.00
426	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), UGDH(3), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1), UGT2B4(4)	4394820	22	20	22	5	6	8	6	1	1	0	0.90	1.00
427	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1), HADHA(2), SDS(2)	1318802	5	5	5	7	0	2	1	0	2	0	0.90	1.00
428	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(1), LUM(1)	967608	4	4	4	2	0	3	1	0	0	0	0.90	1.00
429	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(4), DNMT1(4), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTR(5)	4733020	25	22	25	17	5	11	6	1	2	0	0.90	1.00
430	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(1), HRAS(2), IGF1R(1), IRS1(4), MAP2K1(2), MAPK1(1), MAPK3(2), PIK3R1(1), RAF1(1), SHC1(1), SOS1(6)	4499306	22	22	22	4	6	8	5	2	1	0	0.91	1.00
431	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), FOS(1), HRAS(2), IL2RB(2), IL2RG(1), JAK1(1), JAK3(7), JUN(2), LCK(2), MAP2K1(2), MAPK3(2), MAPK8(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	6428648	37	31	37	13	10	14	8	2	3	0	0.91	1.00
432	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), CRKL(1), HRAS(2), JUN(2), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(2), MAPK8(2), PAK1(3), PLCG1(2), PRKCA(5), RAC1(2), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	7794620	48	39	48	14	18	14	9	5	2	0	0.91	1.00
433	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(3), ALPP(1), ALPPL2(1), GCH1(2), SPR(1)	1834468	9	9	9	3	4	4	0	1	0	0	0.91	1.00
434	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(6), ADC(1), ALDH18A1(4), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(2), ASS1(4), GATM(1), NAGS(1), ODC1(1), OTC(2), SMS(4)	7199388	42	34	40	13	11	20	6	2	3	0	0.91	1.00
435	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2)	3593286	17	17	17	5	6	9	0	2	0	0	0.91	1.00
436	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), UGDH(3)	2317560	11	11	11	1	2	8	0	1	0	0	0.91	1.00
437	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), AKT3(2), BPNT1(1), ILK(1), MAPK1(1), MAPK3(2), PDK1(1), PIK3CD(3), RBL2(5), SHC1(1), SOS1(6)	4702582	24	21	24	6	5	7	6	3	3	0	0.91	1.00
438	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25B(3), CDC25C(1), PRKCA(5)	2502858	10	10	10	4	1	6	1	1	1	0	0.91	1.00
439	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(3), ACADVL(1), ACSL1(2), ACSL3(1), CPT1A(3), CPT2(2), DCI(1), EHHADH(1), HADHA(2), PECR(1), SCP2(1), SLC25A20(1)	4528320	22	22	22	12	4	9	5	1	3	0	0.91	1.00
440	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(1), CHRNB1(2), CHRNG(4), MUSK(3), PIK3R1(1), PTK2(3), RAPSN(3), TERT(5)	3938606	22	20	22	12	11	7	1	1	2	0	0.91	1.00
441	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	15	FOS(1), JUN(2), MAPK14(1), MAPK8(2), PLCG1(2), PRKCA(5), SYT1(3)	3344976	16	16	16	8	6	4	2	3	1	0	0.92	1.00
442	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(3), IARS(3), IARS2(4), ILVBL(2), LARS2(5), PDHA1(2), PDHA2(5), VARS(4), VARS2(4)	5037400	33	24	33	10	5	18	6	1	3	0	0.92	1.00
443	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(2), LTA(3), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TANK(4), TNFRSF1A(2), TRADD(1)	6698318	37	29	37	12	8	13	6	3	7	0	0.92	1.00
444	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(12), EP300(5), FYN(4), IL2RG(1), IL7R(3), JAK1(1), JAK3(7), LCK(2), NMI(1), PIK3R1(1), STAT5A(2)	7041502	39	31	38	14	6	15	9	4	5	0	0.92	1.00
445	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(1), EHHADH(1), HADHA(2), HADHB(2), SDS(2)	2252946	9	9	9	9	1	2	2	2	2	0	0.92	1.00
446	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(2), CAPNS2(1), EP300(5), HDAC1(2), MEF2D(2), NFATC2(5), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKCA(5), SYT1(3)	6598994	39	30	38	12	12	11	6	6	4	0	0.92	1.00
447	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(6), ALDH3B2(2), AOC2(2), AOC3(3), DDC(2), EPX(5), ESCO1(1), GOT1(2), GOT2(3), HPD(3), LPO(2), MPO(3), MYST3(11), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1)	8770238	52	42	51	25	15	19	11	4	3	0	0.92	1.00
448	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(7), CDC25B(3), CDC25C(1), CHEK1(4), WEE1(2)	3709342	17	16	17	1	4	8	2	1	2	0	0.92	1.00
449	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CDC42(1), CHUK(2), EGFR(9), F11R(1), GIT1(1), HBEGF(1), IGSF5(1), IKBKB(3), JUN(2), LYN(1), MAP3K14(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(3), NFKB1(2), NFKB2(2), NOD1(5), PAK1(3), PLCG1(2), PLCG2(3), PTPN11(3), PTPRZ1(8), RAC1(2), RELA(3), TJP1(9)	19090856	108	66	107	28	32	29	19	10	18	0	0.93	1.00
450	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA2(1), CD36(1), CREBBP(12), EHHADH(1), EP300(5), HSD17B4(1), JUN(2), LPL(3), MAPK1(1), MAPK3(2), MYC(1), NCOA1(6), NCOR1(4), NCOR2(6), NR0B2(1), NR1H3(2), NRIP1(3), PIK3R1(1), PPARA(2), PRKACB(2), PRKACG(1), PRKAR1A(3), PRKAR1B(1), PRKAR2B(3), PRKCA(5), RB1(7), RELA(3), RXRA(1), SP1(1), STAT5A(2)	16377780	86	61	85	40	18	31	13	9	15	0	0.93	1.00
451	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT3(1), AGPAT6(2), CDS1(2), CHAT(2), CHKA(2), CRLS1(1), DGKA(6), DGKB(4), DGKD(5), DGKE(2), DGKG(2), DGKI(7), DGKZ(3), ESCO1(1), ETNK1(3), GPAM(2), GPD1(2), GPD1L(1), GPD2(2), LYPLA1(5), MYST3(11), MYST4(3), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(6), PLD1(10), PLD2(4), PNPLA3(1), PPAP2B(2), PTDSS1(1), SH3GLB1(1)	18095124	114	70	112	48	34	44	16	7	13	0	0.93	1.00
452	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(2), ATM(7), ATR(11), CCNA1(1), CCND1(1), CDK2(1), E2F1(3), GSK3B(1), HDAC1(2), RB1(7), SKP2(1), TGFB1(1), TGFB2(1)	7767920	39	33	39	11	9	12	6	3	9	0	0.93	1.00
453	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(2), FPR1(1), GNA15(1), GNB1(1), HRAS(2), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(2), NCF2(5), NFATC2(5), NFATC3(3), NFATC4(2), NFKB1(2), PAK1(3), PIK3C2G(7), PLCB1(7), PPP3CA(2), PPP3CB(5), PPP3CC(2), RAC1(2), RAF1(1), RELA(3), SYT1(3)	10537956	75	50	74	26	26	29	6	10	4	0	0.93	1.00
454	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(3), BTK(5), GSK3A(4), GSK3B(1), LYN(1), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PLCG1(2), PRKCE(5), RAC1(2), RPS6KB1(1), VAV2(4)	6962292	39	30	38	16	11	9	8	3	8	0	0.93	1.00
455	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC2(5), NFATC3(3), NFATC4(2), PLCG1(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), PRKCA(5), SP1(1), SP3(1), SYT1(3)	5691372	32	27	32	11	11	11	2	5	3	0	0.93	1.00
456	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(2), LCMT2(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(4)	3831272	20	18	20	5	8	7	2	1	2	0	0.93	1.00
457	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(4), JUN(2), MAPK14(1), THBS1(1)	1984344	10	9	10	1	2	2	4	2	0	0	0.93	1.00
458	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFA(1), DFFB(2), FADD(1), JUN(2), MADD(3), MAP3K1(3), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(1), PRKDC(15), RB1(7), SPTAN1(2), TNFRSF1A(2), TRADD(1)	10863874	53	45	52	20	13	21	5	1	13	0	0.93	1.00
459	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	2544332	11	11	11	6	3	3	2	1	2	0	0.93	1.00
460	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), CBS(4), DNMT1(4), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTAP(1), MTR(5), TAT(1)	5640642	28	25	28	19	6	12	6	1	3	0	0.94	1.00
461	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), AKT3(2), BRAF(7), DAG1(1), DRD2(2), EGFR(9), EPHB2(5), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), KCNJ5(2), KCNJ9(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(7), PLCB2(5), PLCB3(4), PLCB4(4), RAF1(1), RGS20(1), SHC1(1), SOS1(6), SOS2(4), STAT3(1)	15750330	94	66	93	28	27	33	18	5	11	0	0.94	1.00
462	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	DIAPH1(1), FYN(4), GSN(2), HRAS(2), ITGA1(4), ITGB1(4), MAP2K1(2), MAPK1(1), MAPK3(2), MYL2(1), MYLK(7), PIK3R1(1), PTK2(3), PXN(3), RAF1(1), ROCK1(5), SHC1(1), TLN1(8)	9542402	52	42	51	16	10	20	9	9	4	0	0.94	1.00
463	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1), HADH(1), HADHA(2), HSD17B4(1), SIRT1(1), SIRT2(2), VNN2(5)	3154338	13	12	13	9	1	4	3	1	4	0	0.94	1.00
464	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACO2(2), ACSS1(3), ACSS2(2), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	3552346	16	15	16	10	3	8	2	2	1	0	0.94	1.00
465	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(2), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(2), IDH3B(3), MDH1(1), MDH2(1), PC(4), PCK1(3), SDHA(1), SUCLA2(2), SUCLG2(1)	5541852	28	24	28	10	6	11	3	3	5	0	0.94	1.00
466	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(1), BAG4(1), BID(1), BIRC3(3), CASP2(1), CASP6(1), CASP7(2), CASP8(1), CASP9(1), CFLAR(1), CHUK(2), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), GSN(2), MAP3K1(3), MAP3K14(1), MAP3K5(3), MAPK8(2), MDM2(1), NFKB1(2), NUMA1(3), PAK2(1), PRKCD(2), PRKDC(15), PSEN1(1), PSEN2(2), PTK2(3), RASA1(6), RB1(7), RELA(3), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	19149418	91	66	90	32	18	33	10	7	23	0	0.94	1.00
467	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), EHHADH(1), HADHA(2), SDS(2)	3292822	16	14	15	7	1	9	2	1	3	0	0.94	1.00
468	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP6(3), ACPT(2), ALPI(1), ALPL(3), ALPP(1), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), DHRS2(1), PON1(4), PON2(1), PON3(1)	4730528	25	21	25	9	8	8	3	2	4	0	0.94	1.00
469	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC3(3), CASP1(2), CASP10(4), CASP2(1), CASP4(3), CASP6(1), CASP7(2), CASP8(1), CASP9(1), DFFA(1), DFFB(2), GZMB(1), PRF1(2)	5233378	26	23	26	11	6	10	3	2	5	0	0.94	1.00
470	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	2883956	13	13	13	7	2	8	1	2	0	0	0.94	1.00
471	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(8), CAPN7(1), CAPN9(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(3), FYN(4), ILK(1), ITGA10(6), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGA7(3), ITGA8(9), ITGA9(1), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(4), ITGB2(3), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(2), ITGB7(1), ITGB8(3), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAPK10(1), MAPK4(1), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(3), PXN(3), RAC1(2), RAPGEF1(3), ROCK1(5), ROCK2(3), SDCCAG8(5), SHC1(1), SHC3(3), SORBS1(5), SOS1(6), TLN1(8), TNS1(8), VASP(2), VAV2(4), VAV3(1), VCL(2)	36879464	235	108	232	81	60	98	41	14	22	0	0.94	1.00
472	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAK1(1), BAX(1), BCL2L1(2), BID(1), BIRC3(3), BNIP3L(1), CASP1(2), CASP10(4), CASP2(1), CASP4(3), CASP6(1), CASP7(2), CASP8(1), CASP9(1), CHUK(2), DFFA(1), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(3), IRF1(1), IRF3(1), IRF4(3), IRF6(5), JUN(2), LTA(3), MAP3K1(3), MAPK10(1), MDM2(1), MYC(1), NFKB1(2), NFKBIB(1), PLEKHG5(1), PRF1(2), RELA(3), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TRADD(1), TRAF1(4), TRAF3(1)	15460190	80	58	80	34	16	26	13	10	15	0	0.94	1.00
473	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(1), GNA13(1), LPA(11), MAP3K1(3), MAP3K5(3), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), PDK1(1), PHKA2(4), PI3(1), PIK3CB(1), PLD1(10), PLD2(4), PLD3(1), PTK2(3), RDX(1), ROCK1(5), ROCK2(3), SERPINA4(4), SRF(2), TBXA2R(2)	13379548	85	57	82	30	17	37	15	10	6	0	0.94	1.00
474	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(2), FUCA1(1), HEXA(6), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(4), NEU2(2), NEU3(2)	4558580	28	19	28	9	4	14	8	0	2	0	0.94	1.00
475	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(2), FLT3(4), IGF1(2), TGFB1(1), TGFB2(1)	2290504	10	10	10	10	2	4	4	0	0	0	0.94	1.00
476	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGDIB(1), CASP1(2), CASP10(4), CASP8(1), CASP9(1), GZMB(1), JUN(2), PRF1(2)	3454802	15	15	15	10	5	4	2	2	2	0	0.95	1.00
477	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(1), AKT3(2), BCL2L1(2), CBL(4), CBLB(4), CCND1(1), CCND2(3), CCND3(1), CNTFR(1), CREBBP(12), CSF2RB(5), CSF3R(5), EP300(5), EPOR(2), GH1(1), GH2(2), GHR(2), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL10RA(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL13RA2(1), IL20(1), IL20RA(1), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(1), IL26(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL5RA(2), IL6R(1), IL7R(3), JAK1(1), JAK2(3), JAK3(7), LEPR(10), LIFR(4), MPL(3), MYC(1), OSMR(4), PIAS1(3), PIAS2(2), PIAS3(4), PIAS4(3), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(5), PTPN11(3), SOCS2(1), SOCS5(3), SOS1(6), SOS2(4), SPRED1(1), SPRED2(2), STAM(1), STAM2(2), STAT1(2), STAT2(2), STAT3(1), STAT4(4), STAT5A(2), STAT6(1), TYK2(8)	37361666	229	108	227	97	56	86	45	20	22	0	0.95	1.00
478	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(2), SHC1(1), SOS1(6)	2388582	9	9	9	2	1	2	4	1	1	0	0.95	1.00
479	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(7), ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7B(1), COX10(1), COX4I1(1), COX6B1(2), COX7A2(1), NDUFB5(3), NDUFS1(4), NDUFV1(3), NDUFV2(2), SDHA(1), UQCRB(1)	9402494	49	38	48	20	15	13	12	3	6	0	0.95	1.00
480	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(6), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), EHHADH(1), EHMT2(2), GCDH(1), HADHA(2), PLOD1(2), PLOD2(4), PLOD3(4), SDS(2)	10099720	52	42	51	28	5	21	15	4	7	0	0.95	1.00
481	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3B2(2), CYP1A2(1), CYP2B6(3), CYP2C19(6), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2F1(4), CYP2S1(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), GSTA2(1), GSTA4(2), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), MGST1(2), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4)	14629286	88	61	88	37	29	25	23	7	4	0	0.95	1.00
482	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(1), FADD(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	2346218	10	8	10	5	3	2	0	2	3	0	0.95	1.00
483	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(4), ITGB1(4), ITGB3(3), PTK2(3), PXN(3), RAC1(2), SPTAN1(2), TLN1(8)	7784474	44	33	43	22	13	15	5	6	5	0	0.95	1.00
484	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IFNG(1), IKBKB(3), IL4(2), JUN(2), MAP3K1(3), MAP3K5(3), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF9(1)	5344806	28	23	28	12	5	8	9	2	4	0	0.95	1.00
485	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	55	AADAT(1), ABP1(6), ACAT1(1), ACMSD(1), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(11), CARM1(1), CAT(1), CYP1A2(1), DDC(2), EHHADH(1), GCDH(1), HAAO(2), HADH(1), HADHA(2), HSD17B4(1), INMT(3), KMO(3), KYNU(3), LCMT1(2), LCMT2(1), LNX1(2), NFX1(1), OGDH(3), OGDHL(4), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), TDO2(1), TPH1(1), WARS(4), WARS2(1), WBSCR22(4)	15662042	88	64	88	40	23	38	12	8	7	0	0.96	1.00
486	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(2), FOS(1), HRAS(2), JAK2(3), JUN(2), MAP2K1(2), MAPK3(2), MAPK8(2), PLCG1(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	5861184	30	27	30	8	9	10	6	2	3	0	0.96	1.00
487	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(2), GNA12(1), GNA13(1), GNB1(1), MYL2(1), MYLK(7), PLCB1(7), PPP1R12B(3), PRKCA(5), ROCK1(5)	5569976	33	26	33	11	6	16	6	3	2	0	0.96	1.00
488	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), BCR(1), CAPN1(2), CAPNS2(1), CRKL(1), FYN(4), HRAS(2), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(2), MAPK1(1), MAPK3(2), MAPK8(2), PPP1R12B(3), PTK2(3), PXN(3), RAF1(1), ROCK1(5), SHC1(1), SOS1(6), TLN1(8), VCL(2)	12940422	79	54	78	27	19	29	15	10	6	0	0.96	1.00
489	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(1), AKT3(2), CASP8(1), CCL3(2), CD14(1), CD40(1), CD80(2), CD86(1), CHUK(2), FADD(1), FOS(1), IFNA1(1), IFNA10(1), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IKBKB(3), IKBKE(3), IL12A(1), IL12B(3), IL1B(1), IRAK1(4), IRF3(1), JUN(2), LBP(5), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K6(3), MAP3K7(3), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CB(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PIK3R2(4), PIK3R3(2), PIK3R5(2), RAC1(2), RELA(3), STAT1(2), TBK1(3), TICAM1(1), TLR1(3), TLR2(3), TLR3(2), TLR5(3), TLR7(3), TLR8(2), TLR9(1), TOLLIP(1), TRAF3(1), TRAF6(1)	23394718	131	78	130	41	35	43	22	15	16	0	0.96	1.00
490	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCND1(1), CCNE2(2), CDK2(1), E2F1(3), PRB1(2)	2268254	10	10	10	5	2	7	0	0	1	0	0.96	1.00
491	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS2(1), LCMT1(2), LCMT2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(4)	3890012	18	17	18	4	8	5	2	1	2	0	0.96	1.00
492	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(1), ACADM(1), ACADS(3), ACAT1(1), ALDH1B1(3), ALDH2(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(2), AOX1(11), AUH(1), BCAT1(1), BCAT2(3), BCKDHB(2), DBT(1), DLD(2), EHHADH(1), HADH(1), HADHA(2), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(7), MUT(1), OXCT1(2), PCCA(2), PCCB(6)	11653660	69	48	69	22	15	23	13	10	8	0	0.96	1.00
493	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(2), MST1R(1)	1782314	6	6	6	3	2	3	1	0	0	0	0.96	1.00
494	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(2), FADD(1), IKBKB(3), IRAK1(4), MAP3K1(3), MAP3K14(1), MAP3K7(3), NFKB1(2), RELA(3), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6253140	31	25	31	12	8	11	4	3	5	0	0.96	1.00
495	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	108	ADCY1(8), ADCY3(5), ADCY4(4), ADCY5(3), ADCY7(4), ADCY8(13), ADSL(1), ADSS(1), AK5(2), AMPD1(4), AMPD2(1), AMPD3(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(3), ATP5G3(1), CANT1(3), DCK(1), ENPP1(7), ENPP3(4), ENTPD1(1), ENTPD2(1), GART(2), GDA(6), GUCY1A3(6), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(8), GUK1(1), HPRT1(1), IMPDH1(2), NPR1(2), NPR2(5), NT5E(2), PAPSS2(1), PDE1A(2), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(3), PDE6B(3), PDE7B(1), PDE8A(6), PDE9A(2), PFAS(5), PKLR(3), PKM2(1), POLB(1), POLD1(2), POLG(2), POLL(1), POLQ(18), POLR1B(4), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1), PPAT(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(2)	34217830	198	104	194	73	58	83	27	12	18	0	0.96	1.00
496	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(2), MEF2D(2), PPARA(2), PPP3CA(2), PPP3CB(5), PPP3CC(2), SLC2A4(2), SYT1(3)	5542920	31	23	31	11	11	6	3	7	4	0	0.96	1.00
497	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	11	ACO1(1), ACO2(2), GRHPR(1), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3225182	14	13	14	2	3	6	4	1	0	0	0.96	1.00
498	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25B(3), CDC25C(1), CDK7(1), XPO1(2)	2376300	8	8	8	5	0	4	1	3	0	0	0.96	1.00
499	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	30	GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2H2(1), GTF2H4(1), GTF2I(1), GTF2IRD1(4), TAF1(11), TAF2(5), TAF4(1), TAF4B(6), TAF5(2), TAF5L(3), TAF6L(2), TAF7L(1), TAF9(2), TBPL2(1)	8734104	44	37	44	18	13	13	6	5	7	0	0.96	1.00
500	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(6), APOC2(2), CYP7A1(3), HMGCR(2), LDLR(4), LIPC(1), LPL(3), LRP1(14), SCARB1(3)	6764356	38	32	37	22	16	15	5	0	2	0	0.97	1.00
501	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(2), SDHA(1), SDHC(1)	1766116	6	6	6	2	0	3	1	2	0	0	0.97	1.00
502	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(2), DFFA(1), DFFB(2), GZMB(1), TOP2A(3), TOP2B(3)	2721976	12	11	12	5	1	5	4	1	1	0	0.97	1.00
503	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(4), ACADL(2), ACADM(1), ACAT1(1), ALDH1A2(4), ALDH1B1(3), ALDH2(2), ALDH6A1(2), ALDH9A1(2), EHHADH(1), HADHA(2), LDHB(2), LDHC(1), MLYCD(2), MUT(1), PCCA(2), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1)	8878106	46	37	45	16	8	22	7	3	6	0	0.97	1.00
504	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(1), GCDH(1), HADHA(2), SDS(2)	2113928	7	7	7	10	1	2	2	0	2	0	0.97	1.00
505	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	AKT1(1), ATM(7), BAX(1), CPB2(2), CSNK1A1(1), FHL2(2), GADD45A(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(1), NFKBIB(1)	4744590	21	19	21	4	5	7	4	3	2	0	0.97	1.00
506	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), FOS(1), HRAS(2), IL6R(1), JAK1(1), JAK2(3), JAK3(7), JUN(2), MAP2K1(2), MAPK3(2), PTPN11(3), RAF1(1), SHC1(1), SOS1(6), SRF(2), STAT3(1)	6555740	37	30	37	9	9	15	8	3	2	0	0.97	1.00
507	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(1), CASP9(1), CHUK(2), GH1(1), GHR(2), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(3)	3258112	14	12	14	9	1	6	1	4	2	0	0.97	1.00
508	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAK1(1), BAX(1), BCL2L1(2), BID(1), CASP8AP2(6), CASP9(1), CES1(2)	3102540	15	12	15	7	4	4	4	2	1	0	0.97	1.00
509	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNB1(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	3013540	15	12	15	3	5	5	0	3	2	0	0.97	1.00
510	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), AKT1(1), DAG1(1), DGKA(6), ETFA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), MAP2K1(2), MAPK1(1), MAPK3(2), NR1I3(1), PAK1(3), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(7), PIK3CD(3), PIK3R1(1), PSME1(1), RIPK3(1), SGCB(1), VASP(2)	12846260	70	53	70	27	27	21	11	3	8	0	0.97	1.00
511	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), DAXX(3), HRAS(2), HSPB2(1), MAP2K6(3), MAP3K1(3), MAP3K5(3), MAP3K7(3), MAP3K9(4), MAPK14(1), MAPKAPK2(1), MAPKAPK5(4), MEF2A(2), MEF2C(2), MEF2D(2), MYC(1), PLA2G4A(5), RAC1(2), RPS6KA5(3), SHC1(1), STAT1(2), TGFB1(1), TGFB2(1), TRADD(1)	9996480	54	42	54	21	11	20	12	5	6	0	0.97	1.00
512	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB6(1), PSMB8(3), PSMB9(2)	2341234	11	10	10	6	5	4	1	0	1	0	0.97	1.00
513	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(4), CASP6(1), CASP7(2), CASP8(1), CFLAR(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), FAF1(1), JUN(2), MAP3K1(3), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(1), PRKDC(15), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(2)	11532976	60	46	59	14	15	27	6	1	11	0	0.97	1.00
514	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(1), JAK2(3), JAK3(7), STAT1(2), STAT3(1), STAT5A(2), TYK2(8)	5072466	28	22	28	9	9	12	4	1	2	0	0.97	1.00
515	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(8), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(2), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(6), MDH1(1), MDH2(1), ME2(2), ME3(2), PC(4), PCK1(3), PCK2(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(1)	12575344	67	52	67	32	19	32	6	4	6	0	0.97	1.00
516	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BAX(1), BCL2L1(2), BID(1), BIRC3(3), CASP6(1), CASP7(2), CASP8(1), CASP9(1), DFFA(1), DFFB(2)	3689762	17	15	17	8	3	7	2	2	3	0	0.97	1.00
517	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(2), BMP5(5), BMP7(1), BTRC(1), CSNK1A1(1), CSNK1A1L(5), CSNK1G1(2), DHH(1), GLI1(3), GLI2(5), GLI3(6), GSK3B(1), HHIP(1), IHH(1), PRKACA(1), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(6), PTCH2(6), SMO(1), STK36(3), SUFU(3), WNT10B(2), WNT11(2), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(2)	14282186	81	57	81	34	22	28	12	11	8	0	0.97	1.00
518	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(2), B4GALT4(1), B4GALT6(2), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GBGT1(3), GCNT2(1), PIGA(1), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(1), PIGS(1), PIGX(1), PIGZ(3), ST3GAL1(1), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	13400908	69	54	68	41	17	22	17	6	7	0	0.97	1.00
519	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(1), CAT(1), GH1(1), GHR(2), HRAS(2), IGF1(2), IGF1R(1), PIK3R1(1), SHC1(1), SOD2(1)	3007310	13	12	13	5	3	7	1	2	0	0	0.98	1.00
520	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(1), GGT1(2), LTA4H(2), PLA2G2A(1), PLA2G6(6), PTGES(1), PTGS1(2), TBXAS1(5)	4144552	22	17	20	7	4	12	4	1	1	0	0.98	1.00
521	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GALT6(1), B3GAT1(2), B3GAT2(2), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHST3(2), DSE(1), XYLT1(4)	4030810	16	15	16	13	2	7	3	2	2	0	0.98	1.00
522	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(1), AKT3(2), GSK3A(4), GSK3B(1), IRS1(4), IRS2(2), JAK1(1), JAK3(7), MAP4K1(2), MAPK1(1), MAPK3(2), PDK1(1), PIK3CD(3), PIK3R1(1), PPP1R13B(4), RAF1(1), SHC1(1), SOS1(6), SOS2(4), STAT6(1)	9492028	49	38	49	21	9	20	10	4	6	0	0.98	1.00
523	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(5), CDC42(1), CFL1(3), CFL2(1), GDI1(2), GDI2(1), INPPL1(3), ITPR1(5), ITPR2(11), ITPR3(3), LIMK1(1), MYLK(7), MYLK2(2), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PDK1(1), PIK3CD(3), PIK3CG(10), PIK3R1(1), PITX2(3), PPP1R13B(4), RACGAP1(1), ROCK1(5), ROCK2(3), WASL(2)	18413388	105	67	104	44	25	37	18	10	15	0	0.98	1.00
524	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(2), CASP7(2), CASP8(1), GAPDH(3), INSR(7), ITCH(2), MAGI1(5), MAGI2(7), RERE(3), WWP1(1), WWP2(1)	6378808	36	25	36	13	8	12	6	3	7	0	0.98	1.00
525	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(2), GRHPR(1), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3388586	14	13	14	2	3	6	4	1	0	0	0.98	1.00
526	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(1), IKBKB(3), IL1B(1), IL1RAP(2), IL1RN(1), IRAK1(4), IRAK2(1), IRAK3(3), JUN(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TGFB1(1), TGFB2(1), TOLLIP(1), TRAF6(1)	8061264	45	34	45	18	14	16	6	5	4	0	0.98	1.00
527	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF13B(2), TNFSF13(1), TRAF3(1), TRAF5(2), TRAF6(1)	3974740	18	15	18	9	6	4	1	1	6	0	0.98	1.00
528	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), DHRS2(1), ESCO1(1), MYST3(11), MYST4(3), PNPLA3(1), SH3GLB1(1)	6562148	32	28	32	12	11	11	4	2	4	0	0.98	1.00
529	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAK1(1), BAX(1), BCL2L1(2), BID(1), BIRC3(3), CASP2(1), CASP6(1), CASP7(2), CASP8(1), CASP9(1), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(2), MAP3K1(3), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(1), MYC(1), NFKB1(2), PARP1(3), PRF1(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	10022112	48	38	48	27	11	16	5	8	8	0	0.98	1.00
530	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLG(2), POLL(1), POLQ(18)	4560360	24	20	22	4	6	11	3	3	1	0	0.98	1.00
531	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(4), ACACB(8), ACADM(1), ACAT1(1), ACSS1(3), ACSS2(2), ALDH1B1(3), ALDH2(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(2), EHHADH(1), HADHA(2), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(2), MUT(1), PCCA(2), PCCB(6), SUCLA2(2), SUCLG2(1)	10649918	54	43	54	24	15	23	6	4	6	0	0.98	1.00
532	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(2), EXT2(1), EXTL1(2), EXTL3(1), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), NDST1(3), NDST2(1), NDST3(4)	5246906	23	21	23	13	2	12	4	5	0	0	0.98	1.00
533	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), IL4(2)	1697764	6	5	6	6	2	2	1	0	1	0	0.98	1.00
534	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(3), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(2)	3494318	16	14	16	5	5	6	3	1	1	0	0.98	1.00
535	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), HBEGF(1), IFNG(1), NR4A3(2), WDR1(2)	2985950	10	10	10	8	1	4	1	2	2	0	0.98	1.00
536	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), B4GALT3(2), B4GALT5(3), FUT8(2), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN1(1), ST6GAL1(1)	5405504	27	22	27	18	11	8	2	3	3	0	0.99	1.00
537	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL2RG(1), IL4(2), IRS1(4), JAK1(1), JAK3(7), RPS6KB1(1), SHC1(1), STAT6(1)	4071928	19	16	19	9	3	10	5	0	1	0	0.99	1.00
538	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(4), ABCC2(4), ABCG2(1), CES1(2), CES2(1), CYP3A4(1), UGT1A10(2), UGT1A3(1), UGT1A5(3), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2)	5763106	24	22	24	10	7	10	4	2	1	0	0.99	1.00
539	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(2), FOS(1), IKBKB(3), IRAK1(4), JUN(2), MAP2K3(2), MAP2K6(3), MAP3K1(3), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(2), RELA(3), TLR2(3), TLR3(2), TLR7(3), TLR9(1), TOLLIP(1), TRAF6(1)	9458386	46	38	45	13	17	14	5	4	6	0	0.99	1.00
540	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), NPAS2(1), PER1(6), PER2(3), PER3(1)	4651140	23	19	23	11	4	10	7	1	1	0	0.99	1.00
541	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), ACO2(2), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(2), IDH3B(3), MDH1(1), MDH2(1), OGDH(3), OGDHL(4), PC(4), PCK1(3), PCK2(1), SDHA(1), SDHC(1), SUCLA2(2), SUCLG2(1)	8013026	37	31	37	25	8	15	4	4	6	0	0.99	1.00
542	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(2), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1)	3140988	13	13	13	6	5	6	1	0	1	0	0.99	1.00
543	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), PGAP1(3), PIGA(1), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(1), PIGS(1), PIGX(1), PIGZ(3)	6629788	28	25	28	18	6	7	5	6	4	0	0.99	1.00
544	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(4), GGT1(2), LCMT1(2), LCMT2(1), MARS(1), MAT1A(1), PAPSS2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(1), SEPHS1(3), WBSCR22(4)	6761864	30	27	30	15	11	11	2	2	4	0	0.99	1.00
545	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT9(1), GCNT2(1), ST8SIA1(2)	1700256	4	4	4	4	1	1	1	0	1	0	0.99	1.00
546	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(7), BRCA1(6), CHEK1(4), CHEK2(3), GADD45A(1), JUN(2), MAPK8(2), MDM2(1), MRE11A(2), NFKB1(2), RAD50(3), RAD51(1), RBBP8(1), RELA(3)	7873474	40	30	40	9	7	15	4	8	6	0	0.99	1.00
547	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(8), ACSL1(2), ACSL3(1), ACSL5(1), ACSL6(2), ADIPOQ(1), ADIPOR1(1), ADIPOR2(2), AKT1(1), AKT3(2), CD36(1), CHUK(2), CPT1A(3), CPT1C(5), CPT2(2), G6PC(2), G6PC2(2), IKBKB(3), IRS1(4), IRS2(2), IRS4(3), JAK1(1), JAK2(3), JAK3(7), LEPR(10), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), PCK1(3), PCK2(1), POMC(2), PPARA(2), PPARGC1A(5), PRKAA2(2), PRKAB2(1), PRKAG2(4), PRKAG3(2), PRKCQ(4), PTPN11(3), RELA(3), RXRA(1), RXRG(5), SLC2A4(2), STAT3(1), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(8)	22732024	136	79	135	49	42	55	20	7	12	0	0.99	1.00
548	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(2), ACTN1(2), ACTR2(1), AKT1(1), AKT3(2), ARHGEF6(2), ARHGEF7(3), BCAR1(5), BRAF(7), CDC42(1), CSE1L(3), DOCK1(3), EPHB2(5), FYN(4), GRLF1(11), ILK(1), ITGA1(4), ITGA10(6), ITGA11(3), ITGA2(5), ITGA3(2), ITGA4(5), ITGA5(1), ITGA6(6), ITGA7(3), ITGA8(9), ITGA9(1), ITGB3BP(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1), MRAS(3), MYLK(7), MYLK2(2), PAK1(3), PAK2(1), PAK3(3), PAK4(1), PAK6(2), PAK7(4), PIK3CB(1), PKLR(3), PLCG1(2), PLCG2(3), PTK2(3), RAF1(1), RALA(2), ROCK1(5), ROCK2(3), SHC1(1), SOS1(6), SOS2(4), TLN1(8), TLN2(11), VASP(2), WAS(5)	32546588	200	98	198	70	47	84	36	9	24	0	0.99	1.00
549	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(2), IKBKB(3), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TNFAIP3(4), TRAF3(1), TRAF6(1)	4931312	22	17	22	10	5	6	4	2	5	0	0.99	1.00
550	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), ITPKA(1), ITPKB(3)	1687262	5	5	5	3	3	1	1	0	0	0	0.99	1.00
551	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), CTNNB1(3), PTK2(3), PXN(3), VCL(2)	5192438	26	19	26	18	7	9	4	5	1	0	0.99	1.00
552	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(1), AKT3(2), DAG1(1), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), PDK1(1), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(10), PLD2(4), PLD3(1), VN1R1(2)	12327212	66	48	64	21	18	29	7	6	6	0	0.99	1.00
553	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(2), DHRS2(1), EHHADH(1), ESCO1(1), HADHA(2), MYST3(11), MYST4(3), PNPLA3(1), SH3GLB1(1)	8198324	38	33	38	17	10	14	6	2	6	0	0.99	1.00
554	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(2)	1417058	5	4	5	4	1	3	0	1	0	0	0.99	1.00
555	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(2), GOSR1(1), SEC22B(4), SNAP23(1), SNAP25(2), STX10(1), STX11(1), STX5(2), STX7(1), TSNARE1(2), USE1(1), YKT6(1)	4427750	19	18	19	11	6	6	4	2	1	0	0.99	1.00
556	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), HADHA(2), HSD17B12(1), PECR(1), SCD(1)	4036862	16	14	16	4	3	3	4	2	4	0	0.99	1.00
557	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), GART(2), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(2), MTR(5), TYMS(1)	4817926	21	19	21	13	4	6	8	2	1	0	0.99	1.00
558	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(12), CTBP1(1), DLL1(1), DLL3(1), DLL4(2), DTX2(2), DTX3(2), DTX3L(1), DTX4(2), DVL1(3), DVL3(3), EP300(5), HDAC1(2), JAG2(1), LFNG(1), MAML1(2), MAML2(6), MAML3(2), MFNG(2), NCOR2(6), NCSTN(3), NOTCH1(11), NOTCH2(7), NOTCH3(5), NOTCH4(3), PSEN1(1), PSEN2(2), PSENEN(2), SNW1(2)	19396660	93	68	92	34	27	26	15	6	19	0	0.99	1.00
559	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(3), AKT1(1), GNAS(4), GNB1(1), NFKB1(2), NOS3(1), PIK3R1(1), RELA(3), SYT1(3)	4352634	19	15	19	11	5	5	4	4	1	0	0.99	1.00
560	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(7), ATR(11), BRCA1(6), BRCA2(7), CHEK1(4), CHEK2(3), FANCC(2), FANCE(1), FANCF(3), FANCG(2), MRE11A(2), RAD1(1), RAD17(2), RAD50(3), RAD51(1), RAD9A(1), TREX1(1)	11625002	57	44	57	10	14	17	10	8	8	0	0.99	1.00
561	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ACCN1(4), ADCY4(4), ADCY8(13), CACNA1A(8), CACNA1B(1), GNAS(4), GNAT3(1), GNB1(1), GNB3(2), GNG3(1), GRM4(1), ITPR3(3), KCNB1(1), PDE1A(2), PLCB2(5), PRKACA(1), PRKACB(2), PRKACG(1), PRKX(1), SCNN1B(2), SCNN1G(3), TAS1R1(2), TAS2R1(3), TAS2R10(3), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R5(1), TAS2R7(1), TAS2R8(1), TAS2R9(3)	15132492	88	57	88	38	27	32	16	6	7	0	0.99	1.00
562	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(4)	1890716	5	5	5	7	1	3	1	0	0	0	0.99	1.00
563	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(4)	1890716	5	5	5	7	1	3	1	0	0	0	0.99	1.00
564	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(1), ARFGEF2(1), CLTB(2), COPA(8), GBF1(3), KDELR2(2)	4367764	18	17	17	8	8	4	4	1	1	0	0.99	1.00
565	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSB(2), ARSD(1), ARSE(2), GAL3ST1(1), GALC(2), GLA(2), NEU1(4), NEU2(2), NEU3(2), PPAP2B(2), SMPD1(3), SMPD2(2), SPTLC2(3)	5598812	28	23	28	10	8	13	4	2	1	0	0.99	1.00
566	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(4), GGT1(2), MARS(1), MAT1A(1), PAPSS2(1), SEPHS1(3)	3369540	13	11	13	11	4	6	0	1	2	0	0.99	1.00
567	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(1), ATM(7), BAX(1), BCL2L1(2), BID(1), CASP6(1), CASP7(2), CASP9(1), PRKCA(5), PTK2(3), PXN(3), STAT1(2), TLN1(8)	7230004	38	29	37	12	9	17	6	4	2	0	0.99	1.00
568	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG13(8), ALG2(2), ALG5(1), ALG6(3), B4GALT1(1), B4GALT3(2), DHDDS(2), DOLPP1(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(4), MAN1C1(3), MAN2A1(4), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), RPN1(1), ST6GAL1(1), STT3B(1)	11591360	62	45	62	25	23	22	5	6	6	0	0.99	1.00
569	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), SYT1(3)	3177478	11	10	11	6	4	1	1	4	1	0	0.99	1.00
570	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), COPS5(3), EDN1(1), EP300(5), HIF1A(1), JUN(2), NOS3(1), VHL(1)	4582432	18	16	17	10	3	5	6	3	1	0	0.99	1.00
571	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(1), HMGCR(2), IDI1(1), MVD(1), PMVK(1), SC5DL(1), SQLE(2)	3072458	12	11	12	5	3	6	2	1	0	0	0.99	1.00
572	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), AKT3(2), BRD4(2), CAP1(1), CBL(4), CDC42(1), F2RL2(1), FLOT1(2), GSK3A(4), GSK3B(1), INPPL1(3), IRS1(4), IRS2(2), IRS4(3), LNPEP(2), MAPK1(1), MAPK3(2), PARD3(5), PARD6A(2), PDK1(1), PIK3CD(3), PIK3R1(1), PPYR1(3), PTPN1(1), RAF1(1), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(1), SLC2A4(2), SORBS1(5), SOS1(6), SOS2(4), YWHAB(2), YWHAE(1), YWHAQ(1)	15227900	89	56	89	27	18	32	20	7	12	0	0.99	1.00
573	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(1), ACADS(3), ACADVL(1), ACAT1(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL5(1), ACSL6(2), ADH1B(1), ADH1C(1), ADH4(2), ADH5(2), ADH7(1), ADHFE1(2), ALDH1B1(3), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CPT1A(3), CPT1C(5), CPT2(2), CYP4A22(1), DCI(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PECI(1)	13166660	59	50	59	30	12	25	9	8	5	0	0.99	1.00
574	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(1), CASP9(1), DAXX(3), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(1)	3068186	11	10	11	11	4	4	1	1	1	0	0.99	1.00
575	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	MDH1(1), PC(4), PDHA1(2)	2508910	7	7	7	7	0	4	0	1	2	0	0.99	1.00
576	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(1), CABIN1(5), CAMK1G(2), HDAC5(1), IGF1(2), IGF1R(1), INSR(7), MAP2K6(3), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(2), NFATC2(5), PIK3R1(1), PPP3CA(2), PPP3CB(5), PPP3CC(2), SYT1(3)	8922784	48	34	48	17	13	16	7	8	4	0	0.99	1.00
577	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CDC42(1), CREB3(2), CREB5(3), DUSP10(3), EEF2K(3), GADD45A(1), MAP2K3(2), MAP2K6(3), MAP3K4(4), MAP3K5(3), MAP3K7(3), MAPK1(1), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(4), MYEF2(3), NFKB1(2), NR2C2(1), SRF(2), TRAF6(1)	9192632	47	35	47	18	6	18	13	5	5	0	0.99	1.00
578	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(6), AGXT2(2), AKR1B10(1), ALAS1(2), AOC2(2), AOC3(3), CBS(4), CHKA(2), DAO(1), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(3), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSPH(1), RDH11(2), RDH12(2), RDH13(1), SARDH(4), SARS(2), SARS2(2), SDS(2), TARS(3), TARS2(2)	11695846	58	44	58	25	13	25	12	4	4	0	1.00	1.00
579	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(1), FADD(1), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(2), MAPK8(2), NFKB1(2), NSMAF(3), RAF1(1), RELA(3), SMPD1(3), TNFRSF1A(2), TRADD(1)	5630140	28	20	28	13	9	9	5	2	3	0	1.00	1.00
580	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(8), MCAT(4), OLAH(1), OXSM(1)	4429352	18	17	17	11	6	10	1	0	1	0	1.00	1.00
581	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP54(1), SRP68(1), SRP72(1), SRPR(1)	2013536	5	5	5	4	1	2	2	0	0	0	1.00	1.00
582	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDFT1(1), FDPS(1), HMGCR(2), HMGCS1(1), IDI1(1), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(2)	3632980	14	13	14	5	3	7	2	2	0	0	1.00	1.00
583	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(2), RPL10L(4), RPL14(1), RPL19(1), RPL28(1), RPL30(1), RPL32(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(4), RPS11(1), RPS18(2), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS8(1)	6262930	26	23	25	12	5	10	6	3	2	0	1.00	1.00
584	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), MAP3K14(1), NFKB1(2), RELA(3)	2511402	8	6	8	2	1	2	1	1	3	0	1.00	1.00
585	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), GART(2), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(2), MTR(5), TYMS(1)	5119102	21	19	21	13	4	6	8	2	1	0	1.00	1.00
586	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(3), CASP8(1), CFLAR(1), FADD(1), JUN(2), MAP3K7(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), NR2C2(1), RALBP1(1), TNFAIP3(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	7490062	33	26	33	15	7	11	4	7	4	0	1.00	1.00
587	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(2), CAMK2D(1), DAG1(1), ITPKA(1), ITPKB(3), ITPR1(5), ITPR2(11), ITPR3(3), NFAT5(3), PDE6A(3), PDE6B(3), PDE6H(2), SLC6A13(4), TF(7)	9814920	49	39	49	15	20	14	8	1	6	0	1.00	1.00
588	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(1), MYST3(11), MYST4(3), PNPLA3(1), SH3GLB1(1)	4289088	18	15	18	8	5	6	3	1	3	0	1.00	1.00
589	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(1), EIF2B5(1), GSK3B(1), IGF1(2), IGF1R(1), INPPL1(3), PDK2(2), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1)	4542560	15	15	15	8	1	5	2	3	4	0	1.00	1.00
590	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(1), BCR(1), CRKL(1), FOS(1), HRAS(2), JAK2(3), JUN(2), MAP2K1(2), MAP3K1(3), MAPK3(2), MAPK8(2), MYC(1), PIK3R1(1), RAF1(1), SOS1(6), STAT1(2), STAT5A(2)	6979024	33	27	33	7	9	10	8	4	2	0	1.00	1.00
591	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(2), BRAF(7), CEBPA(1), CHUK(2), DAXX(3), FOS(1), HRAS(2), IKBKB(3), JUN(2), MAP2K1(2), MAP2K2(2), MAP2K3(2), MAP2K5(2), MAP2K6(3), MAP3K1(3), MAP3K11(2), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(3), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(6), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(2), MAPK4(1), MAPK6(2), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK5(4), MEF2A(2), MEF2C(2), MEF2D(2), MYC(1), NFKB1(2), PAK1(3), PAK2(1), RAC1(2), RAF1(1), RELA(3), RPS6KA1(4), RPS6KA2(2), RPS6KA3(1), RPS6KA4(3), RPS6KA5(3), RPS6KB1(1), SHC1(1), SP1(1), STAT1(2), TGFB1(1), TGFB2(1), TRADD(1)	26589284	136	80	135	53	34	46	26	12	18	0	1.00	1.00
592	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(3)	1683524	3	3	3	1	2	0	0	1	0	0	1.00	1.00
593	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AICDA(3), CAD(10), CANT1(3), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), ENTPD3(1), ENTPD5(1), ENTPD6(3), NME4(1), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(4), NT5E(2), PNPT1(2), POLA1(5), POLA2(3), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(4), POLR1B(4), POLR1C(1), POLR1D(1), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1), POLR3A(3), POLR3B(2), POLR3G(1), POLR3H(1), PRIM1(2), RFC5(2), RRM1(2), RRM2B(2), TK2(1), TXNRD1(2), TXNRD2(3), TYMS(1), UMPS(1), UPP1(3), UPP2(1), UPRT(1)	21837574	116	72	114	62	27	48	20	6	15	0	1.00	1.00
594	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB6(1), PSMC2(4), PSMC3(1), PSMD1(2), PSMD11(1), PSMD12(1), PSMD13(1)	4277518	16	15	16	12	5	8	2	0	1	0	1.00	1.00
595	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), EPOR(2), GRIN1(1), HIF1A(1), JAK2(3), NFKB1(2), RELA(3), SOD2(1)	3452132	14	10	14	2	3	5	2	1	3	0	1.00	1.00
596	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(7), CCNA1(1), CCNB1(1), CCND1(1), CCND2(3), CCND3(1), CCNE2(2), CDK2(1), CDK7(1), CDKN2C(1), CDKN2D(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(3), GADD45A(1), GBA2(2), MCM2(1), MCM3(1), MCM4(4), MCM5(6), MCM6(2), MCM7(3), MDM2(1), MYC(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLA2(3), POLE2(2), PRIM1(2), RB1(7), RBL1(6), TFDP2(1), TNXB(16), WEE1(2)	20615604	93	68	93	28	21	38	14	7	13	0	1.00	1.00
597	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(1), IL10(1), IL10RA(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(2)	3285880	11	10	11	8	3	5	2	1	0	0	1.00	1.00
598	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(1), BCL2L1(2), CBL(4), CFLAR(1), CRKL(1), E2F1(3), FOS(1), HRAS(2), IL2RB(2), IL2RG(1), IRS1(4), JAK1(1), JAK3(7), MAPK1(1), MAPK3(2), MYC(1), NMI(1), PIK3R1(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	9289642	48	35	48	16	10	22	9	3	4	0	1.00	1.00
599	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(3), EIF2AK3(7), EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G3(3), EIF5(1), EIF5B(1), ETF1(2), KIAA0664(1), PABPC1(1), PABPC3(7), PAIP1(1)	12059144	53	44	53	29	10	21	15	2	5	0	1.00	1.00
600	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(6), AGXT2(2), ALAS1(2), AOC2(2), AOC3(3), CBS(4), CHKA(2), DAO(1), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(3), PISD(1), PLCB2(5), PLCG1(2), PLCG2(3), PSPH(1), SARDH(4), SARS(2), TARS(3)	11524254	52	40	52	23	13	21	11	3	4	0	1.00	1.00
601	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), GAB1(2), GADD45A(1), GCK(1), JUN(2), MAP2K5(2), MAP3K1(3), MAP3K11(2), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(3), MAP3K7(3), MAP3K9(4), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(1), PAPPA(8), SHC1(1), TRAF6(1), ZAK(1)	13536722	67	49	67	25	18	26	13	6	4	0	1.00	1.00
602	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAK1(1), BAX(1), BTK(5), CAD(10), CASP10(4), CASP8(1), CASP8AP2(6), CDK2AP1(1), CSNK1A1(1), DAXX(3), DFFA(1), EGFR(9), EPHB2(5), FADD(1), FAF1(1), FAIM2(1), MAP3K1(3), MAP3K5(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(6), MAPK9(1), MET(3), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(5), NR0B2(1), PTPN13(3), RALBP1(1), ROCK1(5), SMPD1(3), TNFRSF6B(1), TPX2(1), TUFM(1)	20075552	105	64	104	32	27	40	18	7	13	0	1.00	1.00
603	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1)	3743518	11	10	11	5	3	4	0	1	3	0	1.00	1.00
604	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(2), CLK2(2), CLK3(2), CLK4(2), COL2A1(8), CPSF1(3), CPSF2(2), CPSF3(1), CPSF4(4), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DHX15(2), DHX16(2), DHX8(2), DHX9(7), DICER1(7), FUS(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PRPF3(1), PRPF4(3), PRPF4B(4), PRPF8(9), PSKH1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), RNPS1(1), SF3A2(2), SF3A3(1), SF3B1(3), SF3B2(2), SF3B4(1), SF4(3), SFRS12(1), SFRS14(6), SFRS2(2), SFRS4(1), SFRS6(3), SFRS8(3), SNRPA(1), SNRPB(3), SNRPD1(1), SNRPD2(2), SNRPN(1), SPOP(1), SRPK1(2), SRPK2(1), SRRM1(2), SUPT5H(3), U2AF2(1), XRN2(4)	28537138	142	82	136	48	36	53	32	10	11	0	1.00	1.00
605	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(1), CDK2(1), GMNN(2), MCM10(4), MCM2(1), MCM3(1), MCM4(4), MCM5(6), MCM6(2), MCM7(3), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLA2(3), POLD1(2), POLD3(1), POLE2(2), PRIM1(2), RFC1(1), RFC4(4), RFC5(2), RPA4(2), UBB(1), UBC(1)	13878660	54	45	54	24	13	18	13	1	9	0	1.00	1.00
606	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), EBP(1), FDFT1(1), FDPS(1), GGPS1(1), HMGCR(2), HSD17B7(1), IDI1(1), IDI2(1), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(2), TM7SF2(2)	5284998	19	17	19	8	4	10	4	1	0	0	1.00	1.00
607	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(5), POLA2(3), POLB(1), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLG(2), POLG2(1), POLI(2), POLK(3), POLL(1), POLM(1), POLQ(18), PRIM1(2), REV1(5), REV3L(4), RFC5(2)	10953230	56	39	54	14	16	19	13	4	4	0	1.00	1.00
608	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP4(1), ARHGAP6(5), ARHGEF1(2), ARHGEF11(7), ARHGEF5(1), ARPC1A(2), ARPC1B(1), CFL1(3), DIAPH1(1), GSN(2), LIMK1(1), MYL2(1), MYLK(7), OPHN1(1), PIP5K1A(4), PIP5K1B(1), PPP1R12B(3), ROCK1(5), TLN1(8), VCL(2)	12577124	60	43	58	20	10	28	13	6	3	0	1.00	1.00
609	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(4), POLR1C(1), POLR1D(1), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1), POLR3A(3), POLR3B(2), POLR3G(1), POLR3H(1)	6292478	24	20	23	20	7	11	1	2	3	0	1.00	1.00
610	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACOT11(1), DHRS2(1), EHHADH(1), ESCO1(1), GCDH(1), HADHA(2), MYST3(11), MYST4(3), PNPLA3(1), SH3GLB1(1)	6846592	24	21	24	16	6	8	4	1	5	0	1.00	1.00
611	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(4), ANAPC4(3), ANAPC5(3), BTRC(1), CDC27(3), CUL1(3), ITCH(2), RBX1(1), SKP1(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(5), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(1), WWP2(1)	10101144	40	33	40	11	12	12	5	6	5	0	1.00	1.00
612	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(10), CANT1(3), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLG(2), POLL(1), POLQ(18), POLR1B(4), POLR2A(2), POLR2B(2), POLR2D(1), POLR2E(1), POLR2H(1), RRM1(2), TK2(1), TXNRD1(2), TYMS(1), UMPS(1), UPP1(3)	15680732	78	53	76	30	16	36	11	6	9	0	1.00	1.00
613	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BID(1), BIRC3(3), CASP10(4), CASP6(1), CASP7(2), CASP8(1), CASP9(1), CFLAR(1), CHUK(2), DFFA(1), DFFB(2), FADD(1), GAS2(2), MAP3K14(1), NFKB1(2), RELA(3), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(1), TRADD(1)	9154184	34	27	34	14	9	12	2	4	7	0	1.00	1.00
614	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(2), GTF2B(1), GTF2E1(1), GTF2H2(1), GTF2H4(1), ILK(1), POLR1A(4), POLR1B(4), POLR2A(2), POLR2B(2), POLR2E(1), POLR2H(1), POLR3B(2), POLR3D(1), POLR3E(2), POLR3H(1), TAF5(2), TAF9(2), TBP(1)	9538486	33	26	33	22	11	9	3	3	7	0	1.00	1.00
615	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(3), ALPP(1), ALPPL2(1), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(2), DDX23(6), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(1), ERCC2(3), ERCC3(2), GCH1(2), IFIH1(3), NUDT8(1), RAD54L(1), SETX(11), SKIV2L2(2), SMARCA2(3), SPR(1)	17193732	66	45	66	24	18	29	12	3	4	0	1.00	1.00
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		407442	0	0	0	0	0	0	0	0	0	0	1.00	1.00
