E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.032 0.138 -9999.0 0.0 -0.342 80.0 80.0 KLHL20 -0.015 0.102 0.207 12.0 -0.229 53.0 65.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 Rac1/GDP -0.007 0.106 0.256 8.0 -0.246 45.0 53.0 ENAH -0.029 0.136 -9999.0 0.0 -0.346 74.0 74.0 AP1M1 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 RAP1B 0.037 0.012 -9999.0 0.0 0.0 54.0 54.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CDC42/GTP 0.005 0.077 0.158 2.0 -0.197 31.0 33.0 ABI1/Sra1/Nap1 -0.033 0.055 -9999.0 0.0 -0.153 69.0 69.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.067 -9999.0 0.0 -0.111 43.0 43.0 RAPGEF1 -0.027 0.124 0.269 4.0 -0.314 68.0 72.0 CTNND1 0.04 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.145 -9999.0 0.0 -0.346 78.0 78.0 CRK -0.023 0.128 0.251 1.0 -0.338 64.0 65.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.063 -9999.0 0.0 -0.137 41.0 41.0 alphaE/beta7 Integrin 0.048 0.038 -9999.0 0.0 -0.132 17.0 17.0 IQGAP1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 NCKAP1 0.039 0.009 -9999.0 0.0 0.0 26.0 26.0 Rap1/GTP/I-afadin 0.043 0.063 -9999.0 0.0 -0.11 61.0 61.0 DLG1 -0.027 0.129 -9999.0 0.0 -0.354 63.0 63.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.028 0.044 -9999.0 0.0 -0.149 40.0 40.0 MLLT4 0.033 0.016 -9999.0 0.0 0.0 109.0 109.0 ARF6/GTP/NME1/Tiam1 0.047 0.062 -9999.0 0.0 -0.107 61.0 61.0 PI3K -0.034 0.058 -9999.0 0.0 -0.191 40.0 40.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 16.0 16.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.04 0.051 -9999.0 0.0 -0.147 30.0 30.0 TIAM1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 E-cadherin(dimer)/Ca2+ 0.065 0.069 -9999.0 0.0 -0.125 48.0 48.0 AKT1 0.009 0.076 0.161 65.0 -0.155 16.0 81.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 CDH1 0.035 0.015 -9999.0 0.0 0.0 79.0 79.0 RhoA/GDP -0.009 0.106 0.253 4.0 -0.246 48.0 52.0 actin cytoskeleton organization -0.009 0.078 0.172 12.0 -0.167 52.0 64.0 CDC42/GDP -0.007 0.107 0.273 6.0 -0.249 45.0 51.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.075 -9999.0 0.0 -0.199 56.0 56.0 ITGB7 0.038 0.01 -9999.0 0.0 0.0 38.0 38.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.07 0.074 -9999.0 0.0 -0.134 48.0 48.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.053 -9999.0 0.0 -0.105 45.0 45.0 mol:GDP -0.026 0.11 0.249 8.0 -0.278 48.0 56.0 CDC42/GTP/IQGAP1 0.039 0.046 -9999.0 0.0 -0.112 42.0 42.0 JUP 0.037 0.013 -9999.0 0.0 0.0 57.0 57.0 p120 catenin/RhoA/GDP 0.003 0.113 0.264 4.0 -0.259 44.0 48.0 RAC1/GTP/IQGAP1 0.039 0.045 -9999.0 0.0 -0.11 40.0 40.0 PIP5K1C/AP1M1 0.048 0.026 -9999.0 0.0 -0.134 1.0 1.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 CDC42 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 31.0 31.0 positive regulation of S phase of mitotic cell cycle -0.016 0.058 0.101 4.0 -0.118 103.0 107.0 NME1 0.036 0.014 -9999.0 0.0 0.0 71.0 71.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.03 0.138 -9999.0 0.0 -0.356 72.0 72.0 regulation of cell-cell adhesion -0.009 0.06 -9999.0 0.0 -0.154 47.0 47.0 WASF2 -0.007 0.043 0.108 13.0 -0.092 50.0 63.0 Rap1/GTP 0.004 0.084 0.189 18.0 -0.23 26.0 44.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.081 -9999.0 0.0 -0.123 48.0 48.0 CCND1 -0.02 0.071 0.125 2.0 -0.143 105.0 107.0 VAV2 -0.047 0.219 -9999.0 0.0 -0.598 56.0 56.0 RAP1/GDP 0.004 0.095 0.222 9.0 -0.26 26.0 35.0 adherens junction assembly -0.031 0.135 -9999.0 0.0 -0.344 75.0 75.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 PIP5K1C 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 regulation of heterotypic cell-cell adhesion 0.045 0.073 0.216 2.0 -0.123 60.0 62.0 E-cadherin/beta catenin 0.007 0.04 0.144 1.0 -0.228 12.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.031 0.135 -9999.0 0.0 -0.34 77.0 77.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 Rac1/GTP -0.056 0.132 -9999.0 0.0 -0.351 66.0 66.0 E-cadherin/beta catenin/alpha catenin 0.055 0.062 -9999.0 0.0 -0.127 45.0 45.0 ITGAE 0.038 0.011 -9999.0 0.0 0.0 41.0 41.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.147 -9999.0 0.0 -0.353 78.0 78.0