Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.048 0.043 0.145 16.0 -9999.0 0.0 16.0 KIRREL 0.043 0.015 0.083 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.048 0.043 -9999.0 0.0 -0.145 16.0 16.0 PLCG1 0.038 0.011 -9999.0 0.0 0.0 43.0 43.0 ARRB2 0.038 0.011 -9999.0 0.0 0.0 46.0 46.0 WASL 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 Nephrin/NEPH1/podocin/CD2AP 0.073 0.067 -9999.0 0.0 -0.114 34.0 34.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.05 0.144 1.0 -0.146 30.0 31.0 FYN 0.006 0.065 0.163 68.0 -0.123 14.0 82.0 mol:Ca2+ 0.075 0.06 -9999.0 0.0 -0.12 22.0 22.0 mol:DAG 0.076 0.061 0.208 1.0 -0.12 22.0 23.0 NPHS2 0.043 0.018 0.086 2.0 -0.042 15.0 17.0 mol:IP3 0.076 0.061 0.208 1.0 -0.12 22.0 23.0 regulation of endocytosis 0.053 0.056 -9999.0 0.0 -0.116 17.0 17.0 Nephrin/NEPH1/podocin/Cholesterol 0.062 0.047 0.185 1.0 -0.105 17.0 18.0 establishment of cell polarity 0.048 0.043 -9999.0 0.0 -0.145 16.0 16.0 Nephrin/NEPH1/podocin/NCK1-2 0.084 0.076 -9999.0 0.0 -0.108 37.0 37.0 Nephrin/NEPH1/beta Arrestin2 0.055 0.058 -9999.0 0.0 -0.117 17.0 17.0 NPHS1 0.037 0.021 0.085 4.0 -0.043 14.0 18.0 Nephrin/NEPH1/podocin 0.054 0.053 0.217 1.0 -0.122 15.0 16.0 TJP1 0.036 0.013 -9999.0 0.0 0.0 63.0 63.0 NCK1 0.036 0.014 -9999.0 0.0 0.0 70.0 70.0 NCK2 0.041 0.004 -9999.0 0.0 0.0 6.0 6.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.078 0.062 0.212 1.0 -0.12 22.0 23.0 CD2AP 0.037 0.013 -9999.0 0.0 0.0 62.0 62.0 Nephrin/NEPH1/podocin/GRB2 0.082 0.058 0.212 1.0 -0.118 16.0 17.0 GRB2 0.04 0.008 -9999.0 0.0 0.0 21.0 21.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.008 0.07 0.166 76.0 -0.121 2.0 78.0 cytoskeleton organization 0.017 0.054 0.219 10.0 -0.168 11.0 21.0 Nephrin/NEPH1 0.041 0.033 -9999.0 0.0 -0.092 17.0 17.0 Nephrin/NEPH1/ZO-1 0.054 0.06 -9999.0 0.0 -0.127 34.0 34.0