rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(7), ACTR3(3), AKT1(8), AKT2(4), AKT3(8), ANGPTL2(9), ARHGAP1(2), ARHGAP4(15), ARHGEF11(22), BTK(11), CDC42(5), CFL1(1), CFL2(8), GDI1(4), GDI2(3), INPPL1(23), ITPR1(31), ITPR2(38), ITPR3(23), LIMK1(7), MYLK(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDK1(7), PIK3CA(138), PIK3CD(10), PIK3CG(25), PIK3R1(67), PITX2(10), PPP1R13B(7), PTEN(198), RACGAP1(8), RHO(8), ROCK1(27), ROCK2(15), RPS4X(4), SAG(5), WASF1(3), WASL(8)	24593100	836	210	656	135	193	221	160	34	189	39	<1.00e-15	<2.46e-14
2	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(8), EIF4A1(4), EIF4A2(6), EIF4E(4), EIF4G1(15), EIF4G2(8), EIF4G3(26), GHR(10), IRS1(17), MAPK1(2), MAPK14(6), MAPK3(4), MKNK1(6), PABPC1(11), PDK2(5), PDPK1(3), PIK3CA(138), PIK3R1(67), PRKCA(10), PTEN(198), RPS6KB1(3)	9912525	551	208	382	44	101	111	133	26	149	31	<1.00e-15	<2.46e-14
3	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(8), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF4E(4), GSK3B(11), IGF1(3), IGF1R(13), INPPL1(23), PDK2(5), PDPK1(3), PIK3CA(138), PIK3R1(67), PPP2CA(6), PTEN(198), RPS6(6), RPS6KB1(3)	6967089	506	208	333	43	91	92	121	20	149	33	<1.00e-15	<2.46e-14
4	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(8), EIF4A1(4), EIF4A2(6), EIF4B(6), EIF4E(4), EIF4G1(15), EIF4G2(8), EIF4G3(26), MKNK1(6), PDK2(5), PDPK1(3), PIK3CA(138), PIK3R1(67), PPP2CA(6), PTEN(198), RPS6(6), RPS6KB1(3), TSC1(13), TSC2(14)	9012929	536	208	366	42	96	113	124	25	147	31	<1.00e-15	<2.46e-14
5	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(8), AKT2(4), AKT3(8), BRD4(9), CAP1(7), CBL(10), CDC42(5), CDKN2A(1), F2RL2(3), FLOT1(1), FLOT2(3), GRB2(3), GSK3A(9), GSK3B(11), IGFBP1(5), INPPL1(23), IRS1(17), IRS4(20), LNPEP(9), MAPK1(2), MAPK3(4), PARD3(27), PARD6A(1), PDK1(7), PIK3CA(138), PIK3CD(10), PIK3R1(67), PPYR1(7), PTEN(198), PTPN1(4), RAF1(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SERPINB6(4), SHC1(11), SLC2A4(4), SORBS1(22), SOS1(21), SOS2(22), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	20132165	766	208	583	117	159	183	167	32	188	37	<1.00e-15	<2.46e-14
6	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(4), CRK(1), CRKL(5), DOCK1(32), ELK1(2), FOS(6), GAB1(10), GRB2(3), HGF(15), ITGA1(20), ITGB1(12), JUN(1), MAP2K1(2), MAP4K1(13), MAPK1(2), MAPK3(4), MAPK8(7), MET(10), PAK1(3), PIK3CA(138), PIK3R1(67), PTEN(198), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAF1(7), RAP1A(3), RAP1B(2), RASA1(29), SOS1(21), SRC(2), STAT3(12)	15458520	672	205	498	85	136	158	146	27	170	35	<1.00e-15	<2.46e-14
7	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(8), CDKN1B(5), GRB2(3), ILK(8), ITGB1(12), MAPK1(2), MAPK3(4), PDK2(5), PDPK1(3), PIK3CA(138), PIK3R1(67), PTEN(198), PTK2(11), SHC1(11), SOS1(21)	6356683	496	203	321	30	86	92	124	20	141	33	<1.00e-15	<2.46e-14
8	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(8), AKT2(4), AKT3(8), BAD(2), BTK(11), CDKN2A(1), DAPP1(7), GRB2(3), GSK3A(9), GSK3B(11), IARS(13), IGFBP1(5), INPP5D(14), PDK1(7), PIK3CA(138), PPP1R13B(7), PTEN(198), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SHC1(11), SOS1(21), SOS2(22), TEC(5), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	12586696	562	201	396	60	115	137	132	22	132	24	<1.00e-15	<2.46e-14
9	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(8), AKT2(4), AKT3(8), BPNT1(1), GRB2(3), ILK(8), MAPK1(2), MAPK3(4), PDK1(7), PIK3CA(138), PIK3CD(10), PTEN(198), PTK2B(16), RBL2(21), SHC1(11), SOS1(21)	6977366	460	198	293	36	98	93	112	20	112	25	<1.00e-15	<2.46e-14
10	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(12), AKT1(8), AKT2(4), AKT3(8), APAF1(19), ATM(54), BAD(2), BAX(4), BCL2L1(3), BID(3), BIRC2(13), BIRC3(3), CAPN1(4), CAPN2(6), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CFLAR(7), CHUK(11), CSF2RB(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1RAP(2), IL3RA(11), IRAK1(5), IRAK2(7), IRAK3(13), IRAK4(6), MAP3K14(12), MYD88(1), NFKB1(12), NFKB2(10), NFKBIA(3), NTRK1(11), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), RELA(6), RIPK1(8), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFRSF1A(6), TNFSF10(1), TP53(40), TRAF2(5)	28018448	775	186	659	164	177	260	136	44	141	17	<1.00e-15	<2.46e-14
11	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(8), APC(53), AXIN1(8), CCND1(10), CD14(2), CTNNB1(66), FZD1(2), GJA1(6), GNAI1(4), GSK3B(11), IRAK1(5), LBP(4), LEF1(9), LY96(4), MYD88(1), NFKB1(12), PDPK1(3), PIK3CA(138), PIK3R1(67), PPP2CA(6), RELA(6), TIRAP(3), TLR4(14), WNT1(1)	9896751	443	180	302	51	100	134	89	35	68	17	<1.00e-15	<2.46e-14
12	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(8), BID(3), BRAF(12), CASP3(4), CD244(4), CD247(5), CD48(4), FAS(7), FASLG(6), FCER1G(1), FCGR3A(2), FCGR3B(5), FYN(7), GRB2(3), GZMB(2), HCST(2), HLA-A(5), HLA-B(3), HLA-E(2), HLA-G(3), ICAM1(3), ICAM2(5), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), ITGAL(13), ITGB2(14), KIR2DL1(6), KIR2DL3(2), KIR2DL4(3), KIR3DL1(7), KIR3DL2(7), KLRC1(2), KLRC2(3), KLRC3(1), KLRD1(2), KLRK1(1), KRAS(29), LCK(5), LCP2(7), MAP2K1(2), MAPK1(2), MAPK3(4), MICB(3), NCR1(5), NCR2(5), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NRAS(10), PAK1(3), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRF1(8), PRKCA(10), PRKCG(10), PTK2B(16), PTPN11(8), RAC2(2), RAF1(7), SH2D1A(3), SH2D1B(2), SH3BP2(10), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SYK(6), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(1), VAV1(16), VAV2(5), VAV3(13), ZAP70(10)	37982119	912	179	781	215	262	304	162	48	117	19	<1.00e-15	<2.46e-14
13	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(8), APC(53), AR(5), ASAH1(9), BRAF(12), CAMP(1), CCL13(2), CCL15(2), CCL16(1), DAG1(7), EGFR(20), GNA11(3), GNA15(1), GNAI1(4), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), MAPK10(9), MAPK14(6), PHKA2(15), PIK3CA(138), PIK3CD(10), PIK3R1(67), PITX2(10), PTX3(2), RAF1(7), SRC(2)	18416145	519	173	422	102	133	166	101	23	75	21	<1.00e-15	<2.46e-14
14	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	46	ACOX1(4), APOA2(2), CD36(7), CITED2(1), CREBBP(37), DUSP1(2), DUT(1), EHHADH(9), EP300(29), FABP1(5), HSD17B4(10), JUN(1), LPL(11), MAPK1(2), MAPK3(4), ME1(10), MRPL11(1), MYC(7), NCOA1(17), NCOR1(24), NCOR2(24), NFKBIA(3), NR0B2(2), NR1H3(5), NR2F1(5), NRIP1(18), PIK3CA(138), PIK3R1(67), PPARA(2), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PTGS2(7), RB1(31), RELA(6), RXRA(1), SP1(6), SRA1(3), STAT5A(5), STAT5B(5), TNF(1)	20595586	552	170	455	104	132	172	107	31	91	19	<1.00e-15	<2.46e-14
15	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(8), CCND1(10), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN1B(5), E2F1(12), MAPK1(2), MAPK3(4), NFKB1(12), NFKBIA(3), PAK1(3), PIK3CA(138), PIK3R1(67), RAF1(7), RB1(31), RELA(6)	7013216	321	168	225	30	69	81	79	20	57	15	<1.00e-15	<2.46e-14
16	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(17), ARHGEF1(11), F2(9), F2R(8), GNA12(10), GNA13(9), GNAI1(4), GNB1(3), MAP3K7(8), PIK3CA(138), PIK3R1(67), PLCB1(6), PPP1R12B(18), PRKCA(10), PTK2B(16), ROCK1(27)	8804043	361	167	269	44	100	94	77	21	52	17	<1.00e-15	<2.46e-14
17	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(8), CREB1(5), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAP3K1(31), MAPK1(2), MAPK14(6), MAPK3(4), NFKB1(12), PIK3CA(138), PIK3R1(67), RB1(31), RELA(6), SP1(6)	6777084	335	166	240	27	74	85	80	23	56	17	<1.00e-15	<2.46e-14
18	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), INSR(18), IRS1(17), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PIK3CA(138), PIK3R1(67), PTPN11(8), RAF1(7), RASA1(29), SHC1(11), SLC2A4(4), SOS1(21), SRF(3)	8735450	357	164	263	40	94	97	74	18	59	15	<1.00e-15	<2.46e-14
19	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IGF1(3), IGF1R(13), IRS1(17), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PIK3CA(138), PIK3R1(67), PTPN11(8), RAF1(7), RASA1(29), SHC1(11), SOS1(21), SRF(3)	8569106	351	162	257	35	91	91	75	20	59	15	<1.00e-15	<2.46e-14
20	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(8), PIK3CA(138), PIK3R1(67), PLCB1(6), PLCG1(12), PRKCA(10), VAV1(16)	4554623	257	159	161	29	64	57	64	15	44	13	<1.00e-15	<2.46e-14
21	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(5), IL18(1), ITGB1(12), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(3), KLRD1(2), MAP2K1(2), MAPK3(4), PAK1(3), PIK3CA(138), PIK3R1(67), PTK2B(16), SYK(6), VAV1(16)	6553380	283	155	191	28	72	66	67	16	49	13	<1.00e-15	<2.46e-14
22	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(9), ANAPC1(30), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(12), ANAPC7(3), ATM(54), ATR(38), BUB1(9), BUB1B(6), BUB3(5), CCNA1(4), CCNA2(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND1(10), CCND2(7), CCND3(5), CCNE2(6), CCNH(3), CDC14A(8), CDC14B(6), CDC16(1), CDC20(5), CDC23(4), CDC25A(9), CDC25B(3), CDC25C(8), CDC27(22), CDC6(3), CDC7(13), CDK2(5), CDK4(4), CDK6(3), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), CHEK1(4), CHEK2(14), CREBBP(37), CUL1(12), DBF4(11), E2F1(12), E2F2(1), E2F3(5), EP300(29), ESPL1(10), GSK3B(11), HDAC1(4), HDAC2(5), MAD1L1(15), MAD2L1(5), MAD2L2(3), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), PCNA(3), PLK1(6), PRKDC(70), PTTG1(5), PTTG2(1), RB1(31), RBL1(17), RBL2(21), RBX1(1), SKP1(2), SKP2(6), SMAD2(12), SMAD3(4), SMAD4(5), SMC1A(19), SMC1B(22), TGFB1(4), TGFB2(6), TGFB3(9), TP53(40), WEE1(1), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	47280892	898	134	856	189	208	354	120	52	140	24	<1.00e-15	<2.46e-14
23	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(53), AXIN1(8), CREBBP(37), CTNNB1(66), EP300(29), FZD1(2), GSK3B(11), HDAC1(4), LDB1(3), LEF1(9), PITX2(10), TRRAP(72), WNT1(1)	10889796	305	121	252	50	75	121	40	24	37	8	<1.00e-15	<2.46e-14
24	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(53), AXIN1(8), BTRC(13), CCND1(10), CREBBP(37), CSNK1A1(5), CSNK2A1(9), CTNNB1(66), FZD1(2), GSK3B(11), HDAC1(4), MAP3K7(8), MYC(7), NLK(5), PPARD(6), PPP2CA(6), TLE1(12), WIF1(5), WNT1(1)	9313591	268	118	218	45	70	107	33	21	29	8	<1.00e-15	<2.46e-14
25	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(11), DNAJC3(8), EIF2S1(1), EIF2S2(5), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), TP53(40)	3408618	98	57	87	11	21	31	18	7	21	0	<1.00e-15	<2.46e-14
26	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	CRK(1), CXCL12(3), CXCR4(1), GNAI1(4), GNB1(3), MAP2K1(2), MAPK1(2), MAPK3(4), NFKB1(12), PIK3C2G(22), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), PTK2(11), PTK2B(16), PXN(6), RAF1(7), RELA(6)	9319566	327	157	236	53	83	78	78	21	54	13	1.11e-15	2.53e-14
27	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(6), CD3D(3), CD3E(2), CD3G(2), CD80(7), CD86(6), CTLA4(2), GRB2(3), HLA-DRB1(1), ICOS(2), IL2(4), ITK(10), LCK(5), PIK3CA(138), PIK3R1(67), PTPN11(8)	4556296	266	152	177	17	64	68	66	13	44	11	1.11e-15	2.53e-14
28	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCR(6), BLNK(4), BTK(11), CD19(7), CSK(1), DAG1(7), EPHB2(10), GRB2(3), ITPKB(6), LYN(7), MAP2K1(2), MAPK1(2), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PI3(3), PIK3CA(138), PIK3CD(10), PIK3R1(67), PLCG2(27), PPP1R13B(7), RAF1(7), SERPINA4(8), SHC1(11), SOS1(21), SOS2(22), SYK(6), VAV1(16)	17391791	480	172	379	102	121	156	97	24	65	17	1.33e-15	2.93e-14
29	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(8), DPM2(4), GRB2(3), KLK2(2), NTRK1(11), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), SHC1(11), SOS1(21)	5473339	287	161	191	29	74	74	65	16	45	13	1.67e-15	3.54e-14
30	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(5), ARHGEF2(10), ARPC5(1), CD14(2), CDC42(5), CDH1(15), CLDN1(2), CTNNB1(66), CTTN(8), EZR(6), FYN(7), HCLS1(8), ITGB1(12), LY96(4), NCK1(4), NCK2(8), NCL(2), OCLN(5), PRKCA(10), RHOA(4), ROCK1(27), ROCK2(15), TLR4(14), TLR5(8), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3), WAS(14), WASL(8), YWHAQ(3), YWHAZ(1)	18644629	386	114	336	97	91	175	37	24	57	2	1.78e-15	3.65e-14
31	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	AKT1(8), AKT2(4), AKT3(8), BAD(2), CASP9(3), CDC42(5), KDR(23), KRAS(29), MAP2K1(2), MAPK1(2), MAPK13(2), MAPK14(6), MAPK3(4), MAPKAPK2(6), MAPKAPK3(4), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NOS3(11), NRAS(10), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKCA(10), PRKCG(10), PTGS2(7), PTK2(11), PXN(6), RAC2(2), RAF1(7), SPHK1(2), SPHK2(1), SRC(2), VEGFA(1)	22792474	612	172	489	131	178	183	119	35	86	11	2.00e-15	3.97e-14
32	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(8), AKT2(4), AKT3(8), BRAF(12), CAB39(6), DDIT4(3), EIF4B(6), FIGF(5), HIF1A(17), IGF1(3), MAPK1(2), MAPK3(4), PDPK1(3), PGF(2), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(9), RHEB(2), RICTOR(25), RPS6(6), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15), RPS6KB1(3), RPS6KB2(6), TSC1(13), TSC2(14), ULK2(10), ULK3(5), VEGFA(1), VEGFB(2), VEGFC(7)	16389186	524	171	421	91	134	160	97	33	89	11	2.55e-15	4.56e-14
33	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(37), DAXX(11), PAX3(4), PML(10), RARA(3), RB1(31), SIRT1(8), SP100(15), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TP53(40)	6433641	169	67	156	33	46	60	21	7	31	4	2.55e-15	4.56e-14
34	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(54), ATR(38), CDC25C(8), CHEK1(4), CHEK2(14), TP53(40), YWHAH(4)	5751057	162	75	146	19	31	45	26	10	44	6	2.66e-15	4.56e-14
35	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	37	AKT1(8), ASAH1(9), ATF1(6), BRAF(12), CAMP(1), CREB1(5), CREB3(2), CREB5(6), CREBBP(37), CRKL(5), DAG1(7), EGR1(8), EGR2(8), EGR3(9), ELK1(2), FRS2(7), JUN(1), MAP1B(42), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK8IP1(5), MAPK9(7), NTRK1(11), OPN1LW(4), PIK3C2G(22), PIK3CA(138), PIK3CD(10), PIK3R1(67), PTPN11(8), RPS6KA3(17), SHC1(11), SRC(2), TERF2IP(4)	16072989	509	169	412	99	136	160	92	25	78	18	2.78e-15	4.56e-14
36	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(8), CREB1(5), GRB2(3), MAPK1(2), MAPK3(4), MAPK7(17), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), NTRK1(11), PIK3CA(138), PIK3R1(67), PLCG1(12), RPS6KA1(5), SHC1(11)	6538323	309	166	212	34	75	88	66	16	53	11	2.78e-15	4.56e-14
37	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CREB1(5), CREB3(2), CREB3L1(6), CREB3L2(8), CREB3L3(9), CREB3L4(8), CREBBP(37), CTNNB1(66), DCT(15), DVL2(12), DVL3(7), EDN1(2), EDNRB(2), EP300(29), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD4(4), FZD6(15), FZD7(5), FZD9(7), GNAI1(4), GNAI2(7), GNAI3(3), GNAO1(5), GNAS(25), GSK3B(11), KIT(28), KITLG(2), KRAS(29), LEF1(9), MAP2K1(2), MAPK1(2), MAPK3(4), MITF(3), NRAS(10), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), POMC(2), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), RAF1(7), TCF7(4), TCF7L1(5), TCF7L2(18), TYR(10), TYRP1(6), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1)	34969763	755	152	664	244	205	298	111	52	87	2	2.78e-15	4.56e-14
38	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	123	ACACA(27), ACACB(31), AKT1(8), AKT2(4), AKT3(8), ARAF(8), BAD(2), BRAF(12), CALM2(3), CALM3(1), CALML6(4), CBL(10), CBLB(15), CBLC(5), CRK(1), CRKL(5), ELK1(2), EXOC7(8), FBP1(4), FLOT1(1), FLOT2(3), FOXO1(11), G6PC(6), G6PC2(9), GCK(5), GRB2(3), GSK3B(11), GYS1(12), GYS2(19), IKBKB(15), INPP5D(14), INSR(18), IRS1(17), IRS4(20), KRAS(29), LIPE(7), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MKNK1(6), MKNK2(4), NRAS(10), PCK1(15), PCK2(7), PDE3A(17), PDE3B(15), PDPK1(3), PFKM(7), PFKP(11), PHKA1(17), PHKA2(15), PHKB(14), PHKG1(6), PHKG2(3), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PKLR(10), PKM2(5), PPARGC1A(13), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R3A(23), PPP1R3B(3), PPP1R3C(3), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKACA(4), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(4), PTPN1(4), PTPRF(34), PYGB(10), PYGL(9), PYGM(10), RAF1(7), RAPGEF1(18), RHEB(2), RHOQ(1), RPS6(6), RPS6KB1(3), RPS6KB2(6), SH2B2(2), SHC1(11), SHC3(9), SHC4(7), SLC2A4(4), SOCS2(7), SOCS4(4), SORBS1(22), SOS1(21), SOS2(22), SREBF1(6), TRIP10(6), TSC1(13), TSC2(14)	50888597	1233	195	1088	286	324	456	197	55	176	25	2.89e-15	4.56e-14
39	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(9), ATM(54), ATR(38), CCNA1(4), CCND1(10), CDC25A(9), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN1B(5), CDKN2A(1), DHFR(3), E2F1(12), GSK3B(11), HDAC1(4), RB1(31), SKP2(6), TGFB1(4), TGFB2(6), TGFB3(9), TP53(40)	10496163	269	92	251	55	53	95	40	12	57	12	2.89e-15	4.56e-14
40	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(7), IFNG(5), IFNGR1(6), IFNGR2(4), IKBKB(15), JAK2(21), LIN7A(8), NFKB1(12), NFKBIA(3), RB1(31), RELA(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TP53(40), USH1C(10), WT1(3)	6203006	181	72	168	44	37	56	34	10	34	10	3.11e-15	4.66e-14
41	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(4), MAX(8), MYC(7), SP1(6), SP3(12), TP53(40), WT1(3)	2433020	80	53	68	12	19	29	11	4	15	2	3.11e-15	4.66e-14
42	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(19), BAK1(4), BAX(4), BCL2L1(3), BID(3), BIRC2(13), BIRC3(3), CASP2(9), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CYCS(3), FADD(1), FAS(7), FASLG(6), GZMB(2), JUN(1), MAP2K4(6), MAP3K1(31), MAP3K14(12), MAPK10(9), MCL1(1), MDM2(6), MYC(7), NFKB1(12), NFKBIA(3), PARP1(11), PRF1(8), RELA(6), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(1), TP53(40), TRAF1(5), TRAF2(5)	12750650	295	91	278	69	70	100	46	23	52	4	3.22e-15	4.66e-14
43	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(11), CALM2(3), CALM3(1), ELK1(2), FCER1A(6), FCER1G(1), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK1(2), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), PAK2(6), PIK3CA(138), PIK3R1(67), PLA2G4A(11), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), RAF1(7), SHC1(11), SOS1(21), SYK(6), SYT1(4), VAV1(16)	14521640	444	166	347	68	127	116	87	25	72	17	3.33e-15	4.66e-14
44	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(17), AKT1(8), BAD(2), BAX(4), BCL2L1(3), CSF2RB(11), IGF1(3), IGF1R(13), IL3RA(11), KIT(28), KITLG(2), PIK3CA(138), PIK3R1(67), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), YWHAH(4)	7329891	340	165	245	47	86	97	70	21	53	13	3.33e-15	4.66e-14
45	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(9), CDKN2A(1), E2F1(12), MDM2(6), MYC(7), PIK3CA(138), PIK3R1(67), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), RB1(31), TBX2(4), TP53(40)	7008436	352	168	249	48	91	84	72	24	66	15	4.00e-15	5.24e-14
46	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	231	ACVR1B(6), ACVR1C(7), AKT1(8), AKT2(4), AKT3(8), ARRB1(7), ARRB2(3), ATF2(6), ATF4(4), BDNF(8), BRAF(12), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1F(36), CACNA1G(20), CACNA1I(13), CACNA1S(33), CACNA2D1(14), CACNA2D2(9), CACNA2D3(20), CACNA2D4(18), CACNB1(9), CACNB2(11), CACNB3(6), CACNB4(14), CACNG2(3), CACNG3(9), CACNG4(6), CACNG5(4), CACNG6(6), CACNG7(10), CASP3(4), CD14(2), CDC25B(3), CDC42(5), CHUK(11), CRK(1), CRKL(5), DAXX(11), DDIT3(1), DUSP1(2), DUSP10(7), DUSP14(3), DUSP16(13), DUSP2(4), DUSP3(2), DUSP4(1), DUSP5(5), DUSP6(1), DUSP7(4), DUSP9(8), ECSIT(5), EGF(24), EGFR(20), ELK1(2), ELK4(3), FAS(7), FASLG(6), FGF1(1), FGF10(1), FGF11(2), FGF12(4), FGF13(6), FGF14(3), FGF16(1), FGF17(1), FGF18(2), FGF21(3), FGF23(6), FGF5(8), FGF6(2), FGF7(6), FGF8(2), FGF9(2), FGFR1(10), FGFR2(27), FGFR4(11), FLNA(31), FLNB(38), FLNC(34), FOS(6), GNA12(10), GNG12(2), GRB2(3), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), JUN(1), KRAS(29), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K5(2), MAP2K6(9), MAP3K1(31), MAP3K10(7), MAP3K12(8), MAP3K13(13), MAP3K14(12), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K6(7), MAP3K7(8), MAP3K8(12), MAP4K1(13), MAP4K2(6), MAP4K3(21), MAP4K4(14), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK7(17), MAPK8(7), MAPK8IP1(5), MAPK9(7), MAPKAPK2(6), MAPKAPK3(4), MAPKAPK5(6), MAPT(11), MAX(8), MEF2C(11), MKNK1(6), MKNK2(4), MOS(8), MRAS(3), MYC(7), NF1(40), NFATC2(15), NFATC4(8), NFKB1(12), NFKB2(10), NLK(5), NR4A1(4), NRAS(10), NTF3(6), NTRK1(11), NTRK2(15), PAK1(3), PAK2(6), PDGFB(4), PDGFRA(29), PDGFRB(12), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PPM1A(7), PPM1B(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PPP5C(7), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PTPN5(5), PTPN7(5), PTPRR(18), RAC2(2), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF2(38), RASA1(29), RASA2(8), RASGRF1(13), RASGRF2(17), RASGRP1(8), RASGRP2(5), RASGRP3(8), RASGRP4(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KA5(7), RPS6KA6(15), RRAS(1), RRAS2(5), SOS1(21), SOS2(22), SRF(3), STK3(9), STK4(6), STMN1(6), TAOK1(10), TAOK2(10), TAOK3(4), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TNF(1), TNFRSF1A(6), TP53(40), TRAF2(5), TRAF6(4), ZAK(12)	95420750	2002	170	1898	575	552	765	258	131	270	26	4.11e-15	5.24e-14
47	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(37), EP300(29), FYN(7), IL2RG(11), IL7(2), IL7R(9), JAK1(31), JAK3(9), LCK(5), NMI(1), PIK3CA(138), PIK3R1(67), PTK2B(16), STAT5A(5), STAT5B(5)	9637675	372	163	274	55	96	96	75	20	68	17	4.22e-15	5.24e-14
48	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), ARHGAP5(24), CD99(2), CDC42(5), CDH5(9), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTNNB1(66), CTNND1(22), CXCL12(3), CXCR4(1), CYBB(12), ESAM(1), EZR(6), F11R(2), GNAI1(4), GNAI2(7), GNAI3(3), ICAM1(3), ITGA4(12), ITGAL(13), ITGAM(24), ITGB1(12), ITGB2(14), ITK(10), JAM2(9), JAM3(3), MAPK13(2), MAPK14(6), MLLT4(32), MMP2(11), MMP9(14), MSN(15), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLPF(2), NCF1(5), NCF2(6), NCF4(8), NOX1(11), NOX3(5), OCLN(5), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(10), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAC2(2), RAP1A(3), RAP1B(2), RAPGEF3(11), RAPGEF4(10), RASSF5(3), RHOA(4), RHOH(2), ROCK1(27), ROCK2(15), SIPA1(3), THY1(1), TXK(6), VASP(2), VAV1(16), VAV2(5), VAV3(13), VCAM1(9), VCL(14)	41763816	1064	194	910	272	284	385	161	61	152	21	4.44e-15	5.24e-14
49	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(8), BAD(2), BCL2L1(3), CBL(10), CFLAR(7), CRKL(5), E2F1(12), FOS(6), GRB2(3), IL2RA(3), IL2RB(6), IL2RG(11), IRS1(17), JAK1(31), JAK3(9), MAPK1(2), MAPK3(4), MYC(7), NMI(1), PIK3CA(138), PIK3R1(67), PPIA(2), RAF1(7), RPS6KB1(3), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5), SYK(6)	12455485	412	169	309	48	102	127	76	22	66	19	4.55e-15	5.24e-14
50	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(53), AXIN1(8), CCND1(10), CCND2(7), CCND3(5), CSNK1E(10), CTNNB1(66), DVL2(12), DVL3(7), FBXW2(3), FOSL1(4), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD6(15), FZD7(5), FZD9(7), GSK3B(11), JUN(1), LDLR(12), MAPK10(9), MAPK9(7), MYC(7), PAFAH1B1(1), PLAU(5), PPP2R5C(6), PPP2R5E(7), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), PRKD1(8), RHOA(4), SFRP4(10), TCF7(4), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1)	18913504	452	127	394	137	130	171	60	36	45	10	4.55e-15	5.24e-14
51	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(17), AKT1(8), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CREB1(5), GNAS(25), GRB2(3), MAPK1(2), MAPK14(6), MAPK3(4), PIK3CA(138), PIK3R1(67), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), RPS6KA1(5), RPS6KA5(7), SOS1(21)	9587963	372	166	273	45	87	111	74	23	62	15	4.77e-15	5.24e-14
52	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(9), ABL2(19), AKT1(8), AKT2(4), AKT3(8), ARAF(8), BAD(2), BRAF(12), BTC(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CBL(10), CBLB(15), CBLC(5), CDKN1A(1), CDKN1B(5), CRK(1), CRKL(5), EGF(24), EGFR(20), ELK1(2), ERBB2(6), ERBB3(16), ERBB4(29), EREG(4), GAB1(10), GRB2(3), GSK3B(11), HBEGF(3), JUN(1), KRAS(29), MAP2K1(2), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MYC(7), NCK1(4), NCK2(8), NRAS(10), NRG1(25), NRG2(6), NRG3(15), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(10), PTK2(11), RAF1(7), RPS6KB1(3), RPS6KB2(6), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SRC(2), STAT5A(5), STAT5B(5), TGFA(3)	34252763	902	182	771	169	241	306	163	50	123	19	5.11e-15	5.24e-14
53	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	163	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY7(6), ADCY8(16), ADCY9(25), ADORA2A(5), ADORA2B(2), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), ATP2A1(16), ATP2A2(9), ATP2A3(12), ATP2B1(17), ATP2B2(12), ATP2B3(21), ATP2B4(18), AVPR1A(8), AVPR1B(3), BDKRB1(5), BDKRB2(9), BST1(5), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1F(36), CACNA1G(20), CACNA1I(13), CACNA1S(33), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CCKAR(12), CCKBR(7), CD38(7), CHRM1(6), CHRM2(9), CHRM3(9), CHRM5(13), CHRNA7(6), CYSLTR1(5), CYSLTR2(6), DRD1(6), EDNRA(6), EDNRB(2), EGFR(20), ERBB2(6), ERBB3(16), ERBB4(29), F2R(8), GNA11(3), GNA14(5), GNA15(1), GNAL(6), GNAS(25), GRIN1(5), GRIN2A(25), GRIN2C(6), GRIN2D(8), GRM1(22), GRM5(22), GRPR(4), HRH1(9), HRH2(3), HTR2A(15), HTR2B(2), HTR2C(18), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), LHCGR(16), LTB4R2(3), MYLK(17), MYLK2(7), NOS1(21), NOS3(11), NTSR1(4), OXTR(4), P2RX1(9), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(3), PDE1A(12), PDE1B(9), PDE1C(14), PDGFRA(29), PDGFRB(12), PHKA1(17), PHKA2(15), PHKB(14), PHKG1(6), PHKG2(3), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PLN(1), PPID(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PTAFR(6), PTGER3(9), PTGFR(10), PTK2B(16), RYR1(80), RYR2(111), RYR3(87), SLC25A4(3), SLC25A5(4), SLC25A6(6), SLC8A1(20), SLC8A2(6), SLC8A3(14), SPHK1(2), SPHK2(1), TACR1(6), TACR2(4), TACR3(9), TNNC1(2), TNNC2(4), TRHR(5), TRPC1(15), VDAC1(2), VDAC3(4)	91936847	1906	151	1852	660	552	781	263	95	192	23	5.11e-15	5.24e-14
54	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(5), ARHGEF2(10), ARPC5(1), CD14(2), CDC42(5), CDH1(15), CLDN1(2), CTNNB1(66), CTTN(8), EZR(6), FYN(7), HCLS1(8), ITGB1(12), LY96(4), NCK1(4), NCK2(8), NCL(2), OCLN(5), PRKCA(10), RHOA(4), ROCK1(27), ROCK2(15), TLR4(14), TLR5(8), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3), WAS(14), WASL(8), YWHAQ(3), YWHAZ(1)	18644629	386	114	336	97	91	175	37	24	57	2	5.11e-15	5.24e-14
55	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(9), ATM(54), BRCA1(19), CDKN1A(1), CHEK1(4), CHEK2(14), JUN(1), MAPK8(7), MDM2(6), MRE11A(12), NFKB1(12), NFKBIA(3), RAD50(19), RAD51(4), RBBP8(10), RELA(6), TP53(40)	10230395	221	81	204	42	37	76	38	13	51	6	5.11e-15	5.24e-14
56	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(8), AKT2(4), AKT3(8), BCL10(2), BLNK(4), BTK(11), CARD11(16), CD19(7), CD22(13), CD72(3), CD79A(1), CD79B(2), CHUK(11), CR2(28), FCGR2B(4), FOS(6), GSK3B(11), IKBKB(15), INPP5D(14), JUN(1), KRAS(29), LILRB3(2), LYN(7), MALT1(4), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NRAS(10), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG2(27), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), RAC2(2), RASGRP3(8), SYK(6), VAV1(16), VAV2(5), VAV3(13)	24626799	679	177	554	151	194	216	128	32	96	13	5.22e-15	5.24e-14
57	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(4), ARF3(2), CCND1(10), CDK2(5), CDK4(4), CDKN1A(1), CDKN1B(5), CDKN2A(1), CFL1(1), E2F1(12), E2F2(1), MDM2(6), PRB1(4), TP53(40)	2760211	96	61	83	20	23	30	14	9	20	0	5.33e-15	5.24e-14
58	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), JAK1(31), JUN(1), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK3(4), MAPK8(7), PDGFRA(29), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), RAF1(7), RASA1(29), SHC1(11), SOS1(21), SRF(3), STAT1(14), STAT3(12), STAT5A(5)	12097702	460	169	352	49	117	114	89	30	85	25	5.55e-15	5.24e-14
59	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(9), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAPK3(4), MPL(5), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), RAF1(7), RASA1(29), SHC1(11), SOS1(21), STAT1(14), STAT3(12), STAT5A(5), STAT5B(5), THPO(11)	10505484	393	161	295	44	99	103	84	22	64	21	5.55e-15	5.24e-14
60	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(19), ATM(54), BAX(4), CCND1(10), CDK2(5), CDK4(4), CDKN1A(1), E2F1(12), MDM2(6), PCNA(3), RB1(31), TIMP3(8), TP53(40)	6289285	197	84	179	34	46	58	31	10	44	8	5.55e-15	5.24e-14
61	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(8), EGFR(20), IGF1R(13), MYC(7), POLR2A(25), PPP2CA(6), PRKCA(10), RB1(31), TEP1(19), TERF1(2), TERT(6), TNKS(20), TP53(40), XRCC5(7)	9669940	214	77	196	62	53	83	27	11	36	4	5.55e-15	5.24e-14
62	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), EGF(24), EGFR(20), ELK1(2), FOS(6), GRB2(3), JAK1(31), JUN(1), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK3(4), MAPK8(7), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), RAF1(7), RASA1(29), SHC1(11), SOS1(21), SRF(3), STAT1(14), STAT3(12), STAT5A(5)	13116798	475	169	368	59	123	120	91	30	88	23	5.66e-15	5.24e-14
63	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(8), AKT2(4), AKT3(8), GRB2(3), IARS(13), IL13RA1(14), IL2RG(11), IL4R(6), INPP5D(14), JAK1(31), JAK2(21), JAK3(9), NR0B2(2), PI3(3), PIK3CA(138), PPP1R13B(7), RPS6KB1(3), SERPINA4(8), SHC1(11), SOS1(21), SOS2(22), SRC(2), STAT6(10), TYK2(7)	12832627	376	137	283	60	94	125	78	21	42	16	5.66e-15	5.24e-14
64	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(11), APC(53), AXIN1(8), BTRC(13), CTNNB1(66), DLL1(8), FZD1(2), GSK3B(11), PSEN1(4), WNT1(1)	5451112	177	98	130	41	37	78	21	20	15	6	5.66e-15	5.24e-14
65	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(19), ATM(54), ATR(38), BAI1(8), BAX(4), BID(3), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND1(10), CCND2(7), CCND3(5), CCNE2(6), CCNG1(6), CCNG2(4), CD82(2), CDK2(5), CDK4(4), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(4), CHEK2(14), CYCS(3), DDB2(5), EI24(7), FAS(7), GTSE1(2), IGF1(3), IGFBP3(7), MDM2(6), MDM4(1), PERP(3), PMAIP1(1), PPM1D(14), PTEN(198), RCHY1(5), RFWD2(6), RRM2(5), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(7), SESN2(3), SESN3(14), SIAH1(3), STEAP3(5), THBS1(12), TNFRSF10B(5), TP53(40), TP53I3(5), TSC2(14), ZMAT3(10)	20733728	660	189	560	119	106	184	124	35	181	30	5.77e-15	5.24e-14
66	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(8), BCR(6), CRKL(5), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK3(4), MAPK8(7), MYC(7), PIK3CA(138), PIK3R1(67), RAF1(7), SOS1(21), STAT1(14), STAT5A(5), STAT5B(5)	9536817	364	167	266	36	94	92	80	23	54	21	5.77e-15	5.24e-14
67	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT1(8), AKT2(4), AKT3(8), BCL2L1(3), CBL(10), CBLB(15), CBLC(5), CCND1(10), CCND2(7), CCND3(5), CLCF1(2), CNTF(3), CNTFR(2), CREBBP(37), CSF2RA(9), CSF2RB(11), CSF3(1), CSF3R(11), EP300(29), EPO(2), EPOR(4), GH1(6), GH2(5), GHR(10), GRB2(3), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), IFNK(2), IFNW1(2), IL10(4), IL10RA(7), IL10RB(9), IL11RA(7), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL13RA1(14), IL13RA2(3), IL15(1), IL15RA(3), IL19(1), IL2(4), IL20(6), IL20RA(3), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(8), IL24(7), IL26(7), IL28A(2), IL28B(4), IL28RA(8), IL29(2), IL2RA(3), IL2RB(6), IL2RG(11), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL6ST(10), IL7(2), IL7R(9), IRF9(6), JAK1(31), JAK2(21), JAK3(9), LEP(2), LEPR(15), LIF(3), LIFR(22), MPL(5), MYC(7), OSM(3), OSMR(12), PIAS1(5), PIAS2(12), PIAS3(9), PIAS4(4), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIM1(4), PRL(6), PRLR(6), PTPN11(8), SOCS2(7), SOCS4(4), SOCS5(12), SOCS7(4), SOS1(21), SOS2(22), SPRED1(8), SPRED2(7), SPRY1(4), SPRY2(6), SPRY4(2), STAM(7), STAM2(7), STAT1(14), STAT2(12), STAT3(12), STAT4(9), STAT5A(5), STAT5B(5), STAT6(10), TPO(18), TSLP(2), TYK2(7)	49995454	1189	191	1069	271	316	413	191	68	170	31	5.88e-15	5.24e-14
68	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(28), AKT1(8), ATM(54), BAX(4), CDKN1A(1), CPB2(7), CSNK1A1(5), FHL2(1), HIF1A(17), IGFBP3(7), MAPK8(7), MDM2(6), NFKBIB(3), NQO1(3), TP53(40)	7045959	191	86	172	42	50	57	29	9	40	6	5.88e-15	5.24e-14
69	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	AKT1(8), AKT2(4), AKT3(8), CASP8(21), CCL3(1), CCL4(1), CCL5(4), CD14(2), CD40(4), CD80(7), CD86(6), CHUK(11), CXCL10(2), CXCL11(1), CXCL9(2), FADD(1), FOS(6), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IKBKB(15), IKBKE(3), IL12A(7), IL12B(3), IL1B(2), IL6(2), IL8(3), IRAK1(5), IRAK4(6), IRF3(6), IRF5(3), JUN(1), LBP(4), LY96(4), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K7(8), MAP3K8(12), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK9(7), MYD88(1), NFKB1(12), NFKB2(10), NFKBIA(3), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), RELA(6), RIPK1(8), SPP1(3), STAT1(14), TBK1(6), TICAM1(8), TICAM2(5), TIRAP(3), TLR1(12), TLR2(12), TLR3(6), TLR4(14), TLR5(8), TLR6(10), TLR7(15), TLR8(18), TLR9(7), TNF(1), TRAF3(6), TRAF6(4)	30048514	757	177	655	156	186	258	141	42	117	13	6.00e-15	5.24e-14
70	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(13), ACTN2(9), ACTN3(10), CSK(1), CTNNA1(18), CTNNA2(13), CTNNB1(66), PTK2(11), PXN(6), SRC(2), VCL(14)	6633684	163	89	113	48	43	71	17	14	18	0	6.00e-15	5.24e-14
71	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(6), GHR(10), GRB2(3), INSR(18), IRS1(17), JAK2(21), MAP2K1(2), MAPK1(2), MAPK3(4), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), RAF1(7), RPS6KA1(5), SHC1(11), SLC2A4(4), SOS1(21), SRF(3), STAT5A(5), STAT5B(5)	11375683	371	163	276	55	93	101	82	21	55	19	6.11e-15	5.24e-14
72	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(3), CALM3(1), CD3D(3), CD3E(2), CD3G(2), ELK1(2), FOS(6), FYN(7), GRB2(3), JUN(1), LCK(5), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKBIA(3), PIK3CA(138), PIK3R1(67), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), PTPN7(5), RAF1(7), RASA1(29), RELA(6), SHC1(11), SOS1(21), SYT1(4), VAV1(16), ZAP70(10)	16411891	488	169	389	74	130	133	92	28	86	19	6.22e-15	5.24e-14
73	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(8), BAD(2), GRB2(3), IGF1R(13), IRS1(17), MAP2K1(2), MAPK1(2), MAPK3(4), PIK3CA(138), PIK3R1(67), RAF1(7), SHC1(11), SOS1(21), YWHAH(4)	6614803	299	163	205	29	72	80	70	17	47	13	6.22e-15	5.24e-14
74	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(17), AKT1(8), ASAH1(9), GNAI1(4), GNB1(3), ITGAV(10), ITGB3(16), MAPK1(2), MAPK3(4), PDGFRA(29), PIK3CA(138), PIK3R1(67), PLCB1(6), PRKCA(10), PTK2(11), SMPD1(12), SMPD2(5), SPHK1(2), SRC(2)	9367366	355	166	260	48	84	102	77	22	57	13	6.33e-15	5.24e-14
75	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(8), AKT2(4), AKT3(8), ANKRD6(14), APC(53), AXIN1(8), AXIN2(1), CER1(2), CSNK1A1(5), CTNNB1(66), DACT1(14), DKK1(4), DKK2(4), DKK3(3), DKK4(3), FSTL1(3), GSK3A(9), GSK3B(11), LRP1(53), MVP(12), NKD1(4), PIN1(1), PSEN1(4), PTPRA(11), SENP2(11), SFRP1(5), TSHB(3), WIF1(5)	13346716	329	115	274	78	92	133	39	26	33	6	6.44e-15	5.24e-14
76	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), AKT1(8), AKT2(4), AKT3(8), AMOTL1(14), ASH1L(40), CASK(20), CDC42(5), CDK4(4), CGN(15), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CRB3(1), CSDA(6), CSNK2A1(9), CSNK2A2(5), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTNNB1(66), CTTN(8), EPB41(11), EPB41L1(11), EPB41L2(13), EPB41L3(18), EXOC3(12), EXOC4(4), F11R(2), GNAI1(4), GNAI2(7), GNAI3(3), HCLS1(8), IGSF5(9), INADL(17), JAM2(9), JAM3(3), KRAS(29), LLGL1(14), LLGL2(5), MAGI1(32), MAGI2(26), MAGI3(17), MLLT4(32), MPDZ(22), MPP5(5), MRAS(3), MYH1(44), MYH10(29), MYH11(39), MYH13(27), MYH14(22), MYH15(22), MYH2(37), MYH3(30), MYH4(36), MYH6(23), MYH7(28), MYH7B(15), MYH8(35), MYH9(26), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLPF(2), NRAS(10), OCLN(5), PARD3(27), PARD6A(1), PARD6B(3), PPM1J(3), PPP2CA(6), PPP2CB(2), PPP2R1A(27), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PPP2R3A(13), PPP2R4(7), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), PTEN(198), RAB13(3), RAB3B(1), RHOA(4), RRAS(1), RRAS2(5), SPTAN1(29), SRC(2), SYMPK(20), TJAP1(8), TJP1(33), TJP2(16), TJP3(6), VAPA(5), YES1(5), ZAK(12)	66353331	1660	209	1466	422	421	596	271	82	253	37	6.55e-15	5.24e-14
77	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(9), ACVR1B(6), ACVRL1(3), AKT1(8), AURKB(5), BMPR1A(8), BMPR2(14), BUB1(9), CDIPT(1), CDKL1(7), CDKL2(6), CDS1(3), CDS2(2), CLK1(9), CLK2(10), CLK4(6), COL4A3BP(3), CSNK2A1(9), CSNK2A2(5), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), IMPA1(4), INPP1(2), INPP4A(23), INPP4B(17), INPP5A(6), INPPL1(23), ITPKB(6), MAP3K10(7), MOS(8), NEK1(20), NEK3(12), OCRL(20), PAK4(2), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3CA(138), PIK3CB(19), PIK3CG(25), PIM2(3), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCG1(12), PLCG2(27), PLK3(12), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), PRKG1(9), RAF1(7), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KB1(3), TGFBR1(8), VRK1(12)	38669961	892	169	789	239	250	310	154	50	116	12	6.55e-15	5.24e-14
78	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), CDC42(5), PAK1(3), PDGFRA(29), PIK3CA(138), PIK3R1(67), WASL(8)	4771157	274	155	183	14	72	64	65	13	47	13	6.99e-15	5.52e-14
79	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(8), APAF1(19), ATM(54), BAD(2), BAX(4), BCL2L1(3), BID(3), CASP3(4), CASP6(4), CASP7(4), CASP9(3), CYCS(3), EIF2S1(1), PRKCA(10), PTK2(11), PXN(6), STAT1(14), TLN1(28), TP53(40)	9696230	221	85	203	49	57	73	37	10	40	4	7.33e-15	5.52e-14
80	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	193	ABI2(4), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), APC(53), ARAF(8), ARHGEF1(11), ARHGEF12(25), ARHGEF4(5), ARHGEF6(19), ARHGEF7(13), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), ARPC5(1), BAIAP2(1), BDKRB1(5), BDKRB2(9), BRAF(12), CD14(2), CDC42(5), CFL1(1), CFL2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CRK(1), CRKL(5), CSK(1), CYFIP1(13), CYFIP2(20), DIAPH1(11), DIAPH2(22), DIAPH3(26), DOCK1(32), EGF(24), EGFR(20), EZR(6), F2(9), F2R(8), FGD1(12), FGD3(12), FGF1(1), FGF10(1), FGF11(2), FGF12(4), FGF13(6), FGF14(3), FGF16(1), FGF17(1), FGF18(2), FGF21(3), FGF23(6), FGF5(8), FGF6(2), FGF7(6), FGF8(2), FGF9(2), FGFR1(10), FGFR2(27), FGFR4(11), FN1(39), GIT1(9), GNA12(10), GNA13(9), GNG12(2), GSN(5), IQGAP1(12), IQGAP2(26), IQGAP3(18), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAD(11), ITGAE(14), ITGAL(13), ITGAM(24), ITGAV(10), ITGAX(9), ITGB1(12), ITGB2(14), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), KRAS(29), LIMK1(7), LIMK2(16), MAP2K1(2), MAPK1(2), MAPK3(4), MOS(8), MRAS(3), MSN(15), MYH10(29), MYH14(22), MYH9(26), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLK(17), MYLK2(7), MYLPF(2), NCKAP1(10), NCKAP1L(18), NRAS(10), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDGFB(4), PDGFRA(29), PDGFRB(12), PFN1(1), PFN2(3), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PPP1R12B(18), PTK2(11), PXN(6), RAC2(2), RAF1(7), RDX(12), RHOA(4), ROCK1(27), ROCK2(15), RRAS(1), RRAS2(5), SCIN(3), SLC9A1(10), SOS1(21), SOS2(22), SSH1(13), SSH2(15), SSH3(3), TIAM1(26), TIAM2(21), TMSL3(1), VAV1(16), VAV2(5), VAV3(13), VCL(14), WAS(14), WASF1(3), WASF2(5), WASL(8)	93008284	2044	200	1873	577	544	770	304	108	281	37	7.44e-15	5.52e-14
81	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(4), AGT(7), AKT1(8), CALM2(3), CALM3(1), CALR(4), CAMK1(9), CAMK1G(5), CAMK4(5), CREBBP(37), CSNK1A1(5), EDN1(2), ELSPBP1(6), F2(9), GATA4(1), GSK3B(11), HAND1(5), HAND2(2), IGF1(3), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), MEF2C(11), MYH2(37), NFATC2(15), NFATC3(12), NFATC4(8), NPPA(1), PIK3CA(138), PIK3R1(67), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), RAF1(7), RPS6KB1(3), SYT1(4)	16973302	500	173	400	97	132	152	95	25	83	13	7.44e-15	5.52e-14
82	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(4), INPP1(2), INPP4A(23), INPP4B(17), INPP5A(6), INPPL1(23), ITPKB(6), OCRL(20), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3CA(138), PIK3CB(19), PIK3CG(25), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCG1(12), PLCG2(27)	15636336	428	144	340	92	122	136	81	23	58	8	7.44e-15	5.52e-14
83	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(54), CDC25A(9), CDC25B(3), CDC25C(8), CDK2(5), CDK4(4), CHEK1(4), RB1(31), TP53(40), WEE1(1), YWHAH(4)	6235032	163	76	146	25	36	44	29	5	41	8	7.44e-15	5.52e-14
84	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(54), ATR(38), BRCA1(19), CCNB1(8), CDC25A(9), CDC25B(3), CDC25C(8), CDKN1A(1), CDKN2D(3), CHEK1(4), CHEK2(14), EP300(29), MDM2(6), PRKDC(70), RPS6KA1(5), TP53(40), WEE1(1), YWHAH(4), YWHAQ(3)	15115316	319	89	298	49	56	102	56	22	74	9	8.22e-15	6.02e-14
85	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM2(3), CALM3(1), CALML6(4), CDIPT(1), CDS1(3), CDS2(2), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), IMPA1(4), IMPA2(6), INPP1(2), INPP4A(23), INPP4B(17), INPP5A(6), INPP5B(8), INPP5D(14), INPPL1(23), ITGB1BP3(1), ITPK1(2), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), OCRL(20), PI4KA(18), PI4KB(12), PIK3C2A(20), PIK3C2B(15), PIK3C2G(22), PIK3C3(11), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PRKCA(10), PRKCG(10), PTEN(198), PTPMT1(1), SYNJ1(27), SYNJ2(13)	42203337	1180	207	994	262	281	346	227	54	229	43	8.33e-15	6.03e-14
86	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	135	APC(53), AXIN1(8), AXIN2(1), BTRC(13), CACYBP(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CCND1(10), CCND2(7), CCND3(5), CER1(2), CHD8(39), CREBBP(37), CSNK1A1(5), CSNK1A1L(4), CSNK1E(10), CSNK2A1(9), CSNK2A2(5), CTBP2(7), CTNNB1(66), CTNNBIP1(2), CUL1(12), CXXC4(1), DAAM1(17), DAAM2(14), DKK1(4), DKK2(4), DKK4(3), DVL2(12), DVL3(7), EP300(29), FBXW11(5), FOSL1(4), FZD1(2), FZD10(7), FZD2(6), FZD3(7), FZD4(4), FZD6(15), FZD7(5), FZD9(7), GSK3B(11), JUN(1), LEF1(9), LRP5(18), LRP6(18), MAP3K7(8), MAPK10(9), MAPK8(7), MAPK9(7), MMP7(3), MYC(7), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NKD1(4), NLK(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PORCN(12), PPARD(6), PPP2CA(6), PPP2CB(2), PPP2R1A(27), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRICKLE1(8), PRICKLE2(6), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), PSEN1(4), RAC2(2), RBX1(1), RHOA(4), ROCK1(27), ROCK2(15), RUVBL1(2), SENP2(11), SFRP1(5), SFRP2(3), SFRP4(10), SFRP5(2), SIAH1(3), SKP1(2), SMAD2(12), SMAD3(4), SMAD4(5), TBL1X(7), TBL1XR1(15), TCF7(4), TCF7L1(5), TCF7L2(18), TP53(40), VANGL1(5), VANGL2(10), WIF1(5), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1)	52544867	1120	178	1035	309	298	440	148	64	152	18	8.66e-15	6.20e-14
87	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(8), AKT2(4), AKT3(8), BCL10(2), CARD11(16), CBL(10), CBLB(15), CBLC(5), CD247(5), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD40LG(7), CD8A(3), CD8B(1), CDC42(5), CDK4(4), CHUK(11), CTLA4(2), FOS(6), FYN(7), GRAP2(3), GRB2(3), ICOS(2), IFNG(5), IKBKB(15), IL10(4), IL2(4), IL5(2), ITK(10), JUN(1), KRAS(29), LCK(5), LCP2(7), MALT1(4), MAP3K14(12), MAP3K8(12), NCK1(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NRAS(10), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PDK1(7), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKCQ(13), PTPRC(15), RASGRP1(8), RHOA(4), SOS1(21), SOS2(22), TEC(5), TNF(1), VAV1(16), VAV2(5), VAV3(13), ZAP70(10)	34057500	853	180	722	192	236	282	152	44	122	17	8.77e-15	6.21e-14
88	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(9), ACTN1(13), ACTR2(7), ACTR3(3), AKT1(8), AKT2(4), AKT3(8), ANGPTL2(9), ARHGEF6(19), ARHGEF7(13), BRAF(12), CDC42(5), CDKN2A(1), CRK(1), CSE1L(15), DOCK1(32), EPHB2(10), FYN(7), GRB2(3), GRB7(3), ILK(8), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGB3BP(2), MAP2K4(6), MAP3K11(5), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7), MRAS(3), MYLK(17), MYLK2(7), P4HB(1), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PIK3CA(138), PIK3CB(19), PKLR(10), PLCG1(12), PLCG2(27), PTEN(198), PTK2(11), RAF1(7), RALA(4), RHO(8), ROCK1(27), ROCK2(15), SHC1(11), SOS1(21), SOS2(22), SRC(2), TERF2IP(4), TLN1(28), TLN2(29), VASP(2), WAS(14), ZYX(12)	41356082	1069	204	884	204	250	325	197	49	220	28	9.44e-15	6.61e-14
89	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(8), CAT(5), GH1(6), GHR(10), IGF1(3), IGF1R(13), PIK3CA(138), PIK3R1(67), SHC1(11), SOD1(2), SOD2(3)	4561793	266	160	174	25	61	71	65	16	42	11	9.66e-15	6.69e-14
90	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(8), BAD(2), CHRNB1(3), CHRNG(9), MUSK(16), PIK3CA(138), PIK3R1(67), PTK2(11), PTK2B(16), RAPSN(4), SRC(2), TERT(6), YWHAH(4)	5431992	286	160	194	42	77	72	67	17	42	11	9.88e-15	6.76e-14
91	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(24), DIAPH1(11), FYN(7), GSN(5), ITGA1(20), ITGB1(12), MAP2K1(2), MAPK1(2), MAPK3(4), MYL2(1), MYLK(17), PFN1(1), PIK3CA(138), PIK3R1(67), PTK2(11), PXN(6), RAF1(7), ROCK1(27), SHC1(11), SRC(2), TLN1(28)	13320665	403	163	309	47	106	118	80	18	66	15	9.99e-15	6.76e-14
92	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCR(6), BLNK(4), BTK(11), CD19(7), CD22(13), CR2(28), CSK(1), DAG1(7), FLOT1(1), FLOT2(3), GRB2(3), GSK3A(9), GSK3B(11), INPP5D(14), ITPR1(31), ITPR2(38), ITPR3(23), LYN(7), MAP4K1(13), MAPK1(2), MAPK3(4), NFATC2(15), NR0B2(2), PDK1(7), PIK3CA(138), PIK3CD(10), PIK3R1(67), PLCG2(27), PPP1R13B(7), PPP3CA(4), PPP3CB(7), PPP3CC(6), PTPRC(15), RAF1(7), SHC1(11), SOS1(21), SOS2(22), SYK(6), VAV1(16)	25226450	646	172	543	151	176	217	121	27	86	19	1.03e-14	6.84e-14
93	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(9), APC(53), ATF2(6), AXIN1(8), BMP10(6), BMP2(5), BMP4(7), BMP5(16), BMP7(15), BMPR1A(8), BMPR2(14), CHRD(14), CTNNB1(66), FZD1(2), GATA4(1), GSK3B(11), MAP3K7(8), MEF2C(11), MYL2(1), NOG(1), NPPA(1), NPPB(2), RFC1(15), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TGFBR3(8), WNT1(1)	11902439	322	112	270	54	81	140	42	24	29	6	1.03e-14	6.84e-14
94	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(19), BAD(2), BAK1(4), BAX(4), BCL2L1(3), BCL2L11(4), BID(3), BIRC2(13), BIRC3(3), BIRC5(4), BNIP3L(2), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CHUK(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), GZMB(2), HELLS(14), IKBKB(15), IRF1(2), IRF2(6), IRF3(6), IRF4(6), IRF5(3), IRF6(9), JUN(1), LTA(3), MAP2K4(6), MAP3K1(31), MAPK10(9), MDM2(6), MYC(7), NFKB1(12), NFKBIA(3), NFKBIB(3), NFKBIE(6), PLEKHG5(5), PRF1(8), RELA(6), RIPK1(8), TNF(1), TNFRSF10B(5), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(1), TNFSF10(1), TP53(40), TRAF1(5), TRAF2(5), TRAF3(6)	19001456	416	99	396	108	100	149	56	27	80	4	1.07e-14	6.98e-14
95	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	44	IMPA1(4), IMPA2(6), INPP1(2), INPP4A(23), INPP4B(17), INPP5A(6), INPP5B(8), INPPL1(23), IPMK(7), ITGB1BP3(1), ITPK1(2), ITPKB(6), MINPP1(5), OCRL(20), PI4KA(18), PI4KB(12), PIK3C3(11), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIP4K2A(4), PIP4K2B(9), PIP4K2C(4), PIP5K1A(7), PIP5K1B(6), PIP5K1C(5), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLCD1(5), PLCD3(7), PLCD4(13), PLCE1(36), PLCG1(12), PLCG2(27), PLCZ1(16), PTEN(198), PTPMT1(1), SYNJ1(27), SYNJ2(13)	24395208	797	198	628	151	187	214	165	38	167	26	1.09e-14	7.05e-14
96	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(8), CABIN1(15), CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), HDAC5(15), IGF1(3), IGF1R(13), INSR(18), MAP2K6(9), MAPK14(6), MAPK7(17), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MYOD1(3), NFATC2(15), PIK3CA(138), PIK3R1(67), PPP3CA(4), PPP3CB(7), PPP3CC(6), SYT1(4), YWHAH(4)	11307568	396	171	301	70	97	125	79	22	62	11	1.21e-14	7.77e-14
97	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(8), BAD(2), BCL2L1(3), CASP9(3), CDC42(5), CHUK(11), ELK1(2), H2AFX(1), MAP2K1(2), MAPK3(4), NFKB1(12), PIK3CA(138), PIK3R1(67), RAF1(7), RALA(4), RALBP1(7), RALGDS(10), RELA(6), RHOA(4)	6509643	296	162	202	20	70	79	73	15	48	11	1.24e-14	7.90e-14
98	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(1), CDK5R1(5), CFL1(1), CHN1(1), LIMK1(7), MAP3K1(31), MYL2(1), MYLK(17), NCF2(6), PAK1(3), PDGFRA(29), PIK3CA(138), PIK3R1(67), PLD1(16), PPP1R12B(18), RALBP1(7), RPS6KB1(3), TRIO(38), VAV1(16), WASF1(3)	12394062	410	163	311	55	108	110	75	22	76	19	1.35e-14	8.51e-14
99	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(8), AKT2(4), AKT3(8), BCR(6), BTK(11), CD19(7), CDKN2A(1), DAPP1(7), FLOT1(1), FLOT2(3), GAB1(10), ITPR1(31), ITPR2(38), ITPR3(23), LYN(7), NR0B2(2), PDK1(7), PHF11(4), PIK3CA(138), PITX2(10), PLCG2(27), PPP1R13B(7), PREX1(25), PTEN(198), PTPRC(15), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SAG(5), SYK(6), TEC(5), VAV1(16)	19405366	671	201	505	125	146	191	142	30	138	24	1.44e-14	8.89e-14
100	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(8), AKT2(4), AKT3(8), BTK(11), FCER1A(6), FCER1G(1), FYN(7), GAB2(12), GRB2(3), IL5(2), INPP5D(14), KRAS(29), LCP2(7), LYN(7), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK9(7), MS4A2(4), NRAS(10), PDK1(7), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCG1(12), PLCG2(27), PRKCA(10), PRKCD(7), PRKCE(11), RAC2(2), RAF1(7), SOS1(21), SOS2(22), SYK(6), TNF(1), VAV1(16), VAV2(5), VAV3(13)	23564205	679	177	549	135	185	207	131	37	100	19	1.44e-14	8.89e-14
101	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(9), DPM2(4), ELK1(2), FOS(6), GRB2(3), JUN(1), KLK2(2), MAP2K1(2), MAPK3(4), MAPK8(7), NGFR(4), PIK3CA(138), PIK3R1(67), PLCG1(12), RAF1(7), SHC1(11), SOS1(21)	6623407	300	156	206	21	82	72	68	17	48	13	1.62e-14	9.86e-14
102	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(8), AKT1(8), ANXA1(4), CALM2(3), CALM3(1), GNAS(25), GNB1(3), NFKB1(12), NOS3(11), NPPA(1), NR3C1(13), PIK3CA(138), PIK3R1(67), RELA(6), SYT1(4)	5881790	304	162	209	26	77	83	70	13	50	11	1.63e-14	9.86e-14
103	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(8), AKT2(4), AKT3(8), BAD(2), BCL2L1(3), CDC42(5), CDK2(5), CDKN1B(5), CDKN2A(1), CREB1(5), CREB3(2), CREB5(6), ERBB4(29), F2RL2(3), GAB1(10), GRB2(3), GSK3A(9), GSK3B(11), IFI27(1), IGF1(3), IGFBP1(5), INPPL1(23), IRS1(17), IRS4(20), MET(10), MYC(7), NOLC1(10), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PARD3(27), PARD6A(1), PDK1(7), PIK3CA(138), PIK3CD(10), PPP1R13B(7), PREX1(25), PTEN(198), PTK2(11), PTPN1(4), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KB1(3), SHC1(11), SLC2A4(4), SOS1(21), SOS2(22), TSC1(13), TSC2(14), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(4), YWHAQ(3), YWHAZ(1)	25549578	822	203	648	135	167	247	174	40	168	26	1.74e-14	1.04e-13
104	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), AKT1(8), AKT2(4), AKT3(8), ARHGAP5(24), BAD(2), BIRC2(13), BIRC3(3), BRAF(12), CAPN2(6), CAV2(1), CCND1(10), CCND2(7), CCND3(5), CDC42(5), CHAD(3), COL11A1(36), COL11A2(13), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A1(33), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), COMP(7), CRK(1), CRKL(5), CTNNB1(66), DIAPH1(11), DOCK1(32), EGF(24), EGFR(20), ELK1(2), ERBB2(6), FARP2(18), FIGF(5), FLNA(31), FLNB(38), FLNC(34), FLT1(23), FN1(39), FYN(7), GRB2(3), GSK3B(11), HGF(15), IBSP(6), IGF1(3), IGF1R(13), ILK(8), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAV(10), ITGB1(12), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), JUN(1), KDR(23), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(4), MAPK8(7), MAPK9(7), MET(10), MYL2(1), MYL5(3), MYL7(4), MYL9(3), MYLK(17), MYLK2(7), MYLPF(2), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PARVA(2), PARVB(2), PARVG(3), PDGFB(4), PDGFC(4), PDGFD(6), PDGFRA(29), PDGFRB(12), PDPK1(3), PGF(2), PIK3CA(138), PIK3CB(19), PIK3CD(10), PIK3CG(25), PIK3R1(67), PIK3R2(4), PIK3R3(8), PIK3R5(8), PIP5K1C(5), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PRKCA(10), PRKCG(10), PTEN(198), PTK2(11), PXN(6), RAC2(2), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF1(18), RELN(48), RHOA(4), ROCK1(27), ROCK2(15), SHC1(11), SHC3(9), SHC4(7), SOS1(21), SOS2(22), SPP1(3), SRC(2), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TLN1(28), TLN2(29), TNC(19), TNN(16), TNR(16), TNXB(25), VASP(2), VAV1(16), VAV2(5), VAV3(13), VCL(14), VEGFA(1), VEGFB(2), VEGFC(7), VWF(31), ZYX(12)	124168387	2735	218	2466	716	658	1022	416	134	427	78	2.24e-14	1.33e-13
105	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(9), ATM(54), BUB1(9), BUB1B(6), BUB3(5), CCNA1(4), CCNA2(3), CCNB1(8), CCNB2(4), CCNB3(20), CCND2(7), CCND3(5), CCNE2(6), CCNH(3), CDAN1(12), CDC14A(8), CDC14B(6), CDC20(5), CDC25A(9), CDC25B(3), CDC25C(8), CDC6(3), CDC7(13), CDH1(15), CDK2(5), CDK4(4), CDKN1A(1), CDKN2A(1), CHEK1(4), CHEK2(14), DTX4(7), E2F1(12), E2F2(1), E2F3(5), E2F4(3), E2F5(1), E2F6(3), EP300(29), ESPL1(10), GSK3B(11), HDAC1(4), HDAC2(5), HDAC3(10), HDAC4(18), HDAC5(15), HDAC6(22), HDAC8(3), MAD1L1(15), MAD2L1(5), MAD2L2(3), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), MPEG1(13), MPL(5), PCNA(3), PLK1(6), PRKDC(70), PTPRA(11), PTTG1(5), PTTG2(1), RB1(31), RBL1(17), SKP2(6), SMAD4(5), TBC1D8(12), TGFB1(4), TP53(40), WEE1(1)	39010775	726	121	691	171	165	304	93	31	116	17	3.06e-14	1.80e-13
106	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(7), ACTR3(3), AKT1(8), ANGPTL2(9), DAG1(7), DGKA(15), ETFA(4), GCA(3), ITGA9(15), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), MAP2K1(2), MAPK1(2), MAPK3(4), NR1I3(7), PAK1(3), PDE3A(17), PDE3B(15), PI3(3), PIK3C2G(22), PIK3CA(138), PIK3CD(10), PIK3R1(67), PLDN(4), PSME1(2), RIPK3(2), RPS4X(4), SGCB(4), VASP(2)	17180993	477	166	382	93	124	148	97	19	72	17	3.31e-14	1.92e-13
107	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	27	DUSP1(2), GORASP1(7), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPK8IP1(5), MAPK9(7), MAPKAPK5(6), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PIK3CA(138), PIK3CD(10), PIK3R1(67), SYT1(4), TRAF2(5), TRAF3(6), TRAF5(8), TRAF6(4)	9658946	341	165	251	39	86	95	73	15	59	13	3.67e-14	2.12e-13
108	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(8), AKT2(4), AKT3(8), BAD(2), GRB2(3), GSK3A(9), GSK3B(11), IL4R(6), IRS1(17), JAK1(31), JAK3(9), MAP4K1(13), MAPK1(2), MAPK3(4), PDK1(7), PIK3CA(138), PIK3CD(10), PIK3R1(67), PPP1R13B(7), RAF1(7), SHC1(11), SOS1(21), SOS2(22), STAT6(10)	12221982	427	169	322	50	98	125	88	22	73	21	3.83e-14	2.18e-13
109	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(4), ACTB(5), ACTN1(13), ACTN2(9), ACTN3(10), ACTN4(11), ACVR1B(6), ACVR1C(7), BAIAP2(1), CDC42(5), CDH1(15), CREBBP(37), CSNK2A1(9), CSNK2A2(5), CTNNA1(18), CTNNA2(13), CTNNA3(13), CTNNB1(66), CTNND1(22), EGFR(20), EP300(29), ERBB2(6), FARP2(18), FER(14), FGFR1(10), FYN(7), IGF1R(13), INSR(18), IQGAP1(12), LEF1(9), LMO7(27), MAP3K7(8), MAPK1(2), MAPK3(4), MET(10), MLLT4(32), NLK(5), PARD3(27), PTPN1(4), PTPRB(31), PTPRF(34), PTPRJ(16), PTPRM(19), PVRL1(9), PVRL2(5), PVRL3(9), PVRL4(5), RAC2(2), RHOA(4), SMAD2(12), SMAD3(4), SMAD4(5), SNAI1(2), SNAI2(8), SORBS1(22), SRC(2), SSX2IP(10), TCF7(4), TCF7L1(5), TCF7L2(18), TGFBR1(8), TGFBR2(6), TJP1(33), VCL(14), WAS(14), WASF1(3), WASF2(5), WASF3(9), WASL(8), YES1(5)	41473192	875	149	804	229	235	346	108	54	118	14	4.33e-14	2.45e-13
110	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(8), BAD(2), CASP9(3), CHUK(11), GH1(6), GHR(10), NFKB1(12), NFKBIA(3), PDPK1(3), PIK3CA(138), PIK3R1(67), PPP2CA(6), RELA(6), YWHAH(4)	5035491	279	160	187	12	64	71	72	16	45	11	5.68e-14	3.18e-13
111	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(7), EIF1(1), EIF2B1(1), EIF2B2(4), EIF2B3(8), EIF2B4(5), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), ELAVL1(6), FLT1(23), FLT4(10), HIF1A(17), KDR(23), NOS3(11), PIK3CA(138), PIK3R1(67), PLCG1(12), PRKCA(10), PTK2(11), PXN(6), SHC1(11), VHL(2)	11075738	391	157	299	57	101	117	77	21	64	11	5.77e-14	3.20e-13
112	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(8), AKT2(4), AKT3(8), CDKN1A(1), ELK1(2), GRB2(3), MAP2K1(2), NGFR(4), NTRK1(11), PIK3CA(138), PIK3CD(10), SHC1(11), SOS1(21)	5241748	223	129	140	25	72	70	53	13	13	2	6.83e-14	3.76e-13
113	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(5), CUL1(12), E2F1(12), FBXW7(34), RB1(31)	2851031	94	47	85	10	17	37	11	5	18	6	1.35e-13	7.38e-13
114	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(54), ATR(38), BRCA1(19), BRCA2(51), CHEK1(4), CHEK2(14), FANCC(8), FANCD2(17), FANCE(10), FANCF(4), FANCG(8), HUS1(5), MRE11A(12), RAD1(3), RAD17(9), RAD50(19), RAD51(4), RAD9A(2), TP53(40), TREX1(1)	15726439	322	90	303	45	69	111	55	16	61	10	3.50e-13	1.89e-12
115	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(8), ATF2(6), CDC42(5), DLD(7), DUSP10(7), DUSP4(1), GAB1(10), GCK(5), IL1R1(5), JUN(1), MAP2K4(6), MAP2K5(2), MAP3K1(31), MAP3K10(7), MAP3K11(5), MAP3K12(8), MAP3K13(13), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K7(8), MAP3K9(6), MAPK10(9), MAPK7(17), MAPK8(7), MAPK9(7), MYEF2(6), NFATC3(12), NR2C2(8), PAPPA(32), SHC1(11), TP53(40), TRAF6(4), ZAK(12)	17052411	367	98	346	98	108	140	43	17	55	4	7.75e-13	4.15e-12
116	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	220	ADCYAP1R1(7), ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), ADRA1A(11), ADRA1B(7), ADRA2B(5), ADRB1(2), ADRB2(8), AGTR2(8), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), C5AR1(5), CALCR(5), CALCRL(9), CCKAR(12), CCKBR(7), CGA(1), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CNR1(8), CNR2(3), CRHR1(2), CRHR2(2), CTSG(3), CYSLTR1(5), CYSLTR2(6), DRD1(6), DRD2(10), DRD3(5), DRD5(11), EDNRA(6), EDNRB(2), F2(9), F2R(8), F2RL1(3), F2RL2(3), FPR1(4), FSHR(17), GABBR1(17), GABBR2(14), GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), GABRB1(8), GABRB2(16), GABRB3(15), GABRE(7), GABRG1(8), GABRG2(19), GABRG3(14), GABRP(5), GABRQ(7), GABRR1(5), GABRR2(2), GALR1(2), GALR3(3), GH1(6), GH2(5), GHR(10), GHRHR(2), GHSR(7), GIPR(4), GLP1R(8), GLP2R(17), GLRA1(9), GLRA2(6), GLRA3(11), GLRB(8), GNRHR(4), GPR156(6), GPR50(8), GPR63(5), GPR83(5), GRIA1(12), GRIA2(25), GRIA3(26), GRIA4(23), GRID1(16), GRID2(13), GRIK1(16), GRIK2(15), GRIK3(17), GRIK4(8), GRIK5(19), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), GRIN3A(15), GRM1(22), GRM2(7), GRM3(20), GRM4(16), GRM5(22), GRM6(15), GRM7(15), GRM8(24), GRPR(4), GZMA(6), HCRTR1(1), HCRTR2(8), HRH1(9), HRH2(3), HRH4(4), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR1F(15), HTR2A(15), HTR2B(2), HTR2C(18), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), LEP(2), LEPR(15), LHB(3), LHCGR(16), LTB4R(3), LTB4R2(3), MAS1(2), MC2R(2), MC3R(8), MC4R(7), MC5R(12), MCHR1(7), MCHR2(1), MLNR(3), MTNR1A(6), MTNR1B(4), NMBR(4), NMUR1(8), NMUR2(7), NPBWR1(2), NPFFR1(2), NPFFR2(12), NPY1R(6), NPY2R(4), NPY5R(10), NR3C1(13), NTSR1(4), NTSR2(2), OPRD1(2), OPRK1(9), OPRM1(11), OXTR(4), P2RX1(9), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(3), P2RY1(2), P2RY10(6), P2RY11(7), P2RY13(3), P2RY14(5), P2RY2(6), P2RY4(7), P2RY6(3), PARD3(27), PPYR1(7), PRL(6), PRLHR(2), PRLR(6), PRSS1(7), PRSS3(2), PTAFR(6), PTGDR(6), PTGER2(5), PTGER3(9), PTGER4(8), PTGFR(10), PTGIR(3), PTH2R(7), RXFP1(16), RXFP2(17), SCTR(4), SSTR1(12), SSTR2(3), SSTR3(6), SSTR4(12), TAAR1(6), TAAR2(5), TAAR5(8), TAAR6(5), TAAR8(3), TAAR9(8), TACR1(6), TACR2(4), TACR3(9), THRA(5), THRB(4), TRHR(5), TRPV1(6), TSHB(3), TSHR(12), VIPR1(3)	73228883	1737	151	1671	557	504	721	265	78	167	2	2.24e-12	1.19e-11
117	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), ANXA6(10), ARRB1(7), ARRB2(3), ATP1A4(24), ATP1B1(3), ATP1B2(7), ATP1B3(4), ATP2A2(9), ATP2A3(12), ATP2B1(17), ATP2B2(12), ATP2B3(21), CACNA1A(19), CACNA1B(1), CACNA1C(30), CACNA1D(34), CACNA1E(47), CACNA1S(33), CACNB1(9), CACNB3(6), CALM2(3), CALM3(1), CALR(4), CAMK1(9), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CASQ1(7), CASQ2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), GJA1(6), GJA4(2), GJB1(1), GJB2(3), GJB3(2), GJB4(5), GJB5(3), GJB6(4), GNA11(3), GNAI2(7), GNAI3(3), GNAO1(5), GNAZ(7), GNB1(3), GNB2(5), GNB3(4), GNB4(3), GNB5(3), GNG12(2), GNG13(2), GNG2(2), GNG3(3), GNG4(5), GRK4(14), GRK5(10), GRK6(3), ITPR1(31), ITPR2(38), ITPR3(23), KCNB1(17), KCNJ3(15), KCNJ5(6), MIB1(8), MYCBP(1), NME7(4), PEA15(2), PKIG(2), PLCB3(9), PLN(1), PRKACA(4), PRKACB(2), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), RGS1(6), RGS10(3), RGS14(5), RGS16(3), RGS17(5), RGS18(2), RGS2(3), RGS20(5), RGS3(15), RGS4(6), RGS5(4), RGS6(7), RGS7(9), RGS9(19), RYR1(80), RYR2(111), RYR3(87), SLC8A1(20), SLC8A3(14), USP5(13), YWHAB(1), YWHAH(4), YWHAQ(3)	65714962	1359	140	1322	465	398	569	152	73	146	21	3.25e-12	1.71e-11
118	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(54), CCNA1(4), CCNB1(8), CCND1(10), CCND2(7), CCND3(5), CCNE2(6), CCNG2(4), CCNH(3), CDC25A(9), CDK2(5), CDK4(4), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), CREB3(2), CREB3L1(6), CREB3L3(9), CREB3L4(8), E2F1(12), E2F2(1), E2F3(5), E2F4(3), E2F5(1), E2F6(3), GBA2(13), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), MDM2(6), MNAT1(2), MYC(7), NACA(20), PCNA(3), POLE(1), POLE2(4), PRIM1(2), RB1(31), RBL1(17), RPA1(6), RPA2(2), RPA3(4), TFDP2(8), TNXB(25), TP53(40), WEE1(1)	26464948	434	99	410	100	114	166	55	25	66	8	9.66e-11	5.04e-10
119	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(8), BRAF(12), C7orf16(3), CACNA1A(19), CRHR1(2), GNA11(3), GNA12(10), GNA13(9), GNAI1(4), GNAI2(7), GNAI3(3), GNAO1(5), GNAS(25), GNAZ(7), GRIA1(12), GRIA2(25), GRIA3(26), GRID2(13), GRM1(22), GRM5(22), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), IGF1(3), IGF1R(13), ITPR1(31), ITPR2(38), ITPR3(23), KRAS(29), LYN(7), MAP2K1(2), MAPK1(2), MAPK3(4), NOS1(21), NOS3(11), NPR1(14), NPR2(16), NRAS(10), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PPP2CA(6), PPP2CB(2), PPP2R1A(27), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), PRKCA(10), PRKCG(10), PRKG1(9), PRKG2(10), RAF1(7), RYR1(80)	37961804	816	124	761	238	217	330	141	35	89	4	1.50e-08	7.77e-08
120	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	54	ALG2(2), BAK1(4), BAX(4), BFAR(9), BTK(11), CAD(38), CASP10(10), CASP3(4), CASP8(21), CASP8AP2(18), CDK2AP1(1), CSNK1A1(5), DAXX(11), DEDD(1), DEDD2(2), DFFA(1), DIABLO(2), EGFR(20), EPHB2(10), FADD(1), FAF1(8), FAIM2(2), IL1A(1), IL8(3), MAP2K4(6), MAP3K1(31), MAP3K5(21), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7), MET(10), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(3), PTPN13(27), RALBP1(7), RIPK1(8), ROCK1(27), SMPD1(12), TP53(40), TPX2(14), TRAF2(5), TUFM(13)	24163856	495	101	470	116	116	193	68	23	85	10	5.95e-08	3.06e-07
121	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(9), ABLIM1(8), ABLIM2(5), ABLIM3(9), ARHGEF12(25), CDC42(5), CDK5(1), CFL1(1), CFL2(8), CXCL12(3), CXCR4(1), DCC(35), DPYSL2(11), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA4(3), EFNA5(1), EFNB1(7), EFNB3(2), EPHA1(14), EPHA2(5), EPHA3(14), EPHA4(17), EPHA5(24), EPHA6(21), EPHA7(9), EPHA8(12), EPHB1(25), EPHB2(10), EPHB3(6), EPHB4(4), EPHB6(10), FES(16), FYN(7), GNAI1(4), GNAI2(7), GNAI3(3), GSK3B(11), ITGB1(12), KRAS(29), L1CAM(16), LIMK1(7), LIMK2(16), LRRC4C(9), MAPK1(2), MAPK3(4), MET(10), NCK1(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NGEF(13), NRAS(10), NRP1(16), NTN1(4), NTN4(5), NTNG1(11), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PLXNA1(22), PLXNA2(29), PLXNA3(19), PLXNB1(12), PLXNC1(29), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PTK2(11), RAC2(2), RASA1(29), RGS3(15), RHOA(4), RHOD(3), RND1(7), ROBO1(25), ROBO2(27), ROBO3(16), ROCK1(27), ROCK2(15), SEMA3A(10), SEMA3B(8), SEMA3C(10), SEMA3D(9), SEMA3E(8), SEMA3F(6), SEMA3G(5), SEMA4A(7), SEMA4B(5), SEMA4C(8), SEMA4D(12), SEMA4F(15), SEMA4G(10), SEMA5A(19), SEMA5B(13), SEMA6A(13), SEMA6C(7), SEMA6D(23), SEMA7A(11), SLIT1(11), SLIT2(30), SLIT3(21), SRGAP1(21), SRGAP2(18), SRGAP3(13), UNC5A(11), UNC5B(9), UNC5C(8), UNC5D(14)	64216432	1292	134	1224	392	356	482	189	56	197	12	2.59e-07	1.32e-06
122	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(19), CARM1(6), CCND1(10), CREBBP(37), EP300(29), ERCC3(11), ESR1(15), GRIP1(12), GTF2A1(5), GTF2E1(4), GTF2F1(6), HDAC1(4), HDAC2(5), HDAC3(10), HDAC4(18), HDAC5(15), HDAC6(22), MEF2C(11), NCOR2(24), NR0B1(8), NRIP1(18), PELP1(13), POLR2A(25), SRA1(3), TBP(5)	15123681	335	81	322	104	56	167	42	14	54	2	5.60e-07	2.83e-06
123	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	APAF1(19), ARHGDIB(2), BAG4(4), BID(3), BIRC2(13), BIRC3(3), CASP2(9), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CFLAR(7), CHUK(11), CRADD(3), CYCS(3), DAXX(11), DFFA(1), DFFB(3), FADD(1), GSN(5), LMNA(8), LMNB1(5), MAP3K1(31), MAP3K14(12), MAP3K5(21), MAPK8(7), MDM2(6), NFKB1(12), NFKBIA(3), NUMA1(28), PAK2(6), PRKCD(7), PRKDC(70), PSEN1(4), PSEN2(5), PTK2(11), RASA1(29), RB1(31), RELA(6), RIPK1(8), SPTAN1(29), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF1(5), TRAF2(5)	23868452	493	87	480	110	118	183	67	32	82	11	1.27e-06	6.37e-06
124	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(53), CDH1(15), CREBBP(37), EP300(29), MAP2K1(2), MAP3K7(8), MAPK3(4), SKIL(13), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6)	8955569	194	67	188	48	48	71	27	11	31	6	1.65e-06	8.20e-06
125	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(4), CCNB1(8), CCND1(10), CCND2(7), CCND3(5), CCNH(3), CDC25A(9), CDK2(5), CDK4(4), CDK6(3), CDK7(6), CDKN1A(1), CDKN1B(5), CDKN2A(1), CDKN2C(3), CDKN2D(3), E2F1(12), RB1(31), RBL1(17)	5378217	137	49	129	24	28	51	19	10	25	4	4.66e-06	0.000023
126	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ATF4(4), CACNA1C(30), CACNA1D(34), CACNA1F(36), CACNA1S(33), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CDC42(5), CGA(1), EGFR(20), ELK1(2), GNA11(3), GNAS(25), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(3), ITPR1(31), ITPR2(38), ITPR3(23), JUN(1), KRAS(29), LHB(3), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K1(31), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK7(17), MAPK8(7), MAPK9(7), MMP14(5), MMP2(11), NRAS(10), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PLD1(16), PLD2(7), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCD(7), PRKX(4), PTK2B(16), RAF1(7), SOS1(21), SOS2(22), SRC(2)	43541259	869	120	821	256	245	355	114	45	96	14	9.54e-06	0.000047
127	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(8), GRB2(3), IL2RG(11), IL4R(6), IRS1(17), JAK1(31), JAK3(9), RPS6KB1(3), SHC1(11), STAT6(10)	5226452	109	51	99	25	21	46	11	5	20	6	0.000012	0.000057
128	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(30), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(12), ANAPC7(3), BTRC(13), CDC16(1), CDC20(5), CDC23(4), CDC27(22), CUL1(12), CUL2(7), CUL3(18), FBXW11(5), FBXW7(34), ITCH(8), RBX1(1), SKP1(2), SKP2(6), SMURF1(10), SMURF2(4), TCEB1(2), UBA1(20), UBE2C(1), UBE2D2(3), UBE2D3(3), UBE2D4(1), UBE2E1(3), UBE2E2(3), UBE2E3(8), VHL(2), WWP1(18), WWP2(7)	13986997	281	76	269	53	54	121	41	26	37	2	0.000017	0.000083
129	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(4), CDK2(5), CUL1(12), E2F1(12), RB1(31), SKP2(6)	2920341	70	35	67	10	14	26	12	3	11	4	0.000031	0.00015
130	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1(9), ACVR1B(6), ACVR1C(7), ACVR2A(14), ACVR2B(8), ACVRL1(3), AMHR2(4), BMP2(5), BMP4(7), BMP5(16), BMP6(6), BMP7(15), BMP8A(3), BMP8B(1), BMPR1A(8), BMPR1B(6), BMPR2(14), CHRD(14), COMP(7), CREBBP(37), CUL1(12), DCN(11), E2F4(3), E2F5(1), EP300(29), FST(7), GDF5(8), GDF6(4), ID1(2), ID2(1), IFNG(5), INHBA(7), INHBB(3), INHBC(4), INHBE(7), LEFTY1(2), LEFTY2(3), LTBP1(19), MAPK1(2), MAPK3(4), MYC(7), NODAL(2), NOG(1), PITX2(10), PPP2CA(6), PPP2CB(2), PPP2R1A(27), PPP2R1B(9), PPP2R2A(15), PPP2R2B(12), PPP2R2C(3), RBL1(17), RBL2(21), RBX1(1), RHOA(4), ROCK1(27), ROCK2(15), RPS6KB1(3), RPS6KB2(6), SKP1(2), SMAD1(1), SMAD2(12), SMAD3(4), SMAD4(5), SMAD5(9), SMAD7(6), SMAD9(1), SMURF1(10), SMURF2(4), SP1(6), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNF(1), ZFYVE16(22), ZFYVE9(16)	33286008	693	107	658	176	199	255	88	32	108	11	0.000034	0.00016
131	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(12), CPEB1(10), EGFR(20), ERBB2(6), ERBB4(29), ETS1(6), ETS2(5), ETV6(9), ETV7(4), FMN2(22), GRB2(3), KRAS(29), MAP2K1(2), MAPK1(2), MAPK3(4), NOTCH2(17), NOTCH3(31), NOTCH4(15), PIWIL1(17), PIWIL2(16), PIWIL3(7), PIWIL4(13), RAF1(7), SOS1(21), SOS2(22), SPIRE1(9)	16203483	338	88	304	55	86	136	59	18	33	6	0.000042	0.00020
132	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(5), CDKN1B(5), CUL1(12), E2F1(12), RB1(31), RBX1(1), SKP2(6), UBE2M(1)	2997060	73	35	70	11	13	30	12	3	11	4	0.000058	0.00027
133	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(6), CDC42(5), CREB1(5), DAXX(11), DDIT3(1), ELK1(2), GRB2(3), HMGN1(1), HSPB2(1), MAP2K4(6), MAP2K6(9), MAP3K1(31), MAP3K5(21), MAP3K7(8), MAP3K9(6), MAPK14(6), MAPKAPK2(6), MAPKAPK5(6), MAX(8), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MKNK1(6), MYC(7), PLA2G4A(11), RIPK1(8), RPS6KA5(7), SHC1(11), STAT1(14), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TRAF2(5)	12697831	264	73	257	68	68	112	30	16	36	2	0.000091	0.00042
134	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(4), ACTA2(7), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADM(2), ARRB1(7), ARRB2(3), ATF1(6), ATF2(6), ATF3(4), ATF4(4), ATF5(9), ATP2A2(9), ATP2A3(12), CACNB3(6), CALCA(1), CALM2(3), CALM3(1), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CNN1(3), CORIN(11), CREB3(2), CRHR1(2), DGKZ(9), ETS2(5), FOS(6), GABPA(5), GABPB2(10), GBA2(13), GJA1(6), GNB1(3), GNB2(5), GNB3(4), GNB4(3), GNB5(3), GNG12(2), GNG13(2), GNG2(2), GNG3(3), GNG4(5), GRK4(14), GRK5(10), GRK6(3), GSTO1(3), GUCA2A(1), GUCA2B(1), GUCY1A3(12), IGFBP1(5), IGFBP2(4), IGFBP3(7), IGFBP6(2), IL1B(2), IL6(2), ITPR1(31), ITPR2(38), ITPR3(23), JUN(1), MIB1(8), MYL2(1), MYL4(1), MYLK2(7), NFKB1(12), NOS1(21), NOS3(11), OXTR(4), PDE4B(17), PDE4D(7), PKIG(2), PLCB3(9), PLCD1(5), PLCG1(12), PLCG2(27), PRKACA(4), PRKACB(2), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(8), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(6), RGS10(3), RGS14(5), RGS16(3), RGS17(5), RGS18(2), RGS2(3), RGS20(5), RGS3(15), RGS4(6), RGS5(4), RGS6(7), RGS7(9), RGS9(19), RLN1(3), RYR1(80), RYR2(111), RYR3(87), SLC8A1(20), SP1(6), TNXB(25), USP5(13), YWHAB(1), YWHAH(4), YWHAQ(3)	60185458	1179	120	1147	405	347	483	147	57	126	19	0.000095	0.00044
135	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(37), EP300(29), ESR1(15), MAPK1(2), MAPK3(4), PELP1(13), SRC(2)	4923400	102	45	98	24	24	39	15	6	18	0	0.00020	0.00090
136	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(54), CDC25A(9), CDC25B(3), CDC25C(8), CHEK1(4), WEE1(1), YWHAH(4)	4817762	83	42	77	16	16	24	16	0	23	4	0.00027	0.0012
137	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IL6(2), IL6R(12), IL6ST(10), JAK1(31), JAK2(21), JAK3(9), JUN(1), MAP2K1(2), MAPK3(4), PTPN11(8), RAF1(7), SHC1(11), SOS1(21), SRF(3), STAT3(12)	8232833	174	57	163	33	40	58	22	14	26	14	0.00031	0.0014
138	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(7), DDX20(6), E2F1(12), E2F4(3), ETS1(6), ETS2(5), ETV3(12), FOS(6), HDAC2(5), HDAC5(15), JUN(1), NCOR2(24), RBL1(17), RBL2(21), SIN3A(28), SIN3B(15)	8035658	188	58	178	44	44	75	22	15	29	3	0.00038	0.0017
139	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	148	ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), AGTR2(8), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), CCBP2(3), CCKAR(12), CCKBR(7), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CCR9(2), CCRL1(4), CCRL2(5), CHML(9), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), CMKLR1(11), CNR1(8), CNR2(3), CX3CR1(4), CXCR3(5), CXCR4(1), DRD1(6), DRD2(10), DRD3(5), DRD5(11), EDNRA(6), EDNRB(2), F2R(8), F2RL1(3), F2RL2(3), FPR1(4), FSHR(17), GALR1(2), GALR3(3), GALT(2), GHSR(7), GNB2L1(2), GPR17(4), GPR174(11), GPR3(5), GPR37(9), GPR37L1(5), GPR4(7), GPR50(8), GPR6(4), GPR63(5), GPR77(3), GPR83(5), GPR85(7), GPR87(8), GRPR(4), HCRTR1(1), HCRTR2(8), HRH1(9), HRH2(3), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR1F(15), HTR2A(15), HTR2B(2), HTR2C(18), HTR4(7), HTR5A(9), HTR6(4), HTR7(4), LHCGR(16), LTB4R(3), MAS1(2), MC3R(8), MC4R(7), MC5R(12), MLNR(3), MTNR1A(6), MTNR1B(4), NMBR(4), NMUR1(8), NMUR2(7), NPY1R(6), NPY2R(4), NPY5R(10), NTSR1(4), NTSR2(2), OPN1SW(6), OPN3(2), OPRD1(2), OPRK1(9), OPRM1(11), OR10A5(5), OR11A1(3), OR12D3(8), OR1F1(3), OR1Q1(3), OR2H1(2), OR5V1(9), OR7A5(6), OR7C1(10), OR8B8(3), OXTR(4), P2RY1(2), P2RY10(6), P2RY11(7), P2RY12(3), P2RY13(3), P2RY14(5), P2RY2(6), P2RY6(3), PPYR1(7), PTAFR(6), PTGDR(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3), RGR(6), RHO(8), RRH(3), SSTR1(12), SSTR2(3), SSTR3(6), SSTR4(12), SUCNR1(3), TRHR(5)	39016511	893	109	866	313	251	397	132	39	74	0	0.00049	0.0022
140	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(17), ADCY8(16), ARAF(8), ATF4(4), BRAF(12), CACNA1C(30), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CREBBP(37), EP300(29), GRIA1(12), GRIA2(25), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), GRM1(22), GRM5(22), ITPR1(31), ITPR2(38), ITPR3(23), KRAS(29), MAP2K1(2), MAPK1(2), MAPK3(4), NRAS(10), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PPP1CA(6), PPP1CB(7), PPP1CC(2), PPP1R12A(12), PPP1R1A(4), PPP3CA(4), PPP3CB(7), PPP3CC(6), PPP3R1(2), PPP3R2(1), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKX(4), RAF1(7), RAP1A(3), RAP1B(2), RAPGEF3(11), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15)	34784060	685	108	641	214	177	261	129	26	90	2	0.00051	0.0022
141	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(6), CTSD(5), ESR1(15), GREB1(16), HSPB2(1), MTA1(4), MTA3(5), PDZK1(4), TUBA8(11)	3412920	67	37	65	17	13	30	8	7	9	0	0.00055	0.0024
142	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(8), ATF1(6), CDC42(5), CREB1(5), CREB3(2), CREB5(6), DUSP1(2), DUSP10(7), EEF2K(11), EIF4E(4), ELK1(2), IL1R1(5), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K10(7), MAP3K4(23), MAP3K5(21), MAP3K7(8), MAPK1(2), MAPK13(2), MAPK14(6), MAPKAPK2(6), MAPKAPK5(6), MKNK1(6), MKNK2(4), MYEF2(6), NFKB1(12), NR2C2(8), SRF(3), TRAF6(4)	11095097	210	64	203	61	49	100	30	9	22	0	0.00065	0.0028
143	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(7), NFYB(2), NFYC(1), RB1(31), SP1(6), SP3(12)	2386176	59	32	56	12	9	21	13	2	10	4	0.00066	0.0028
144	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(31), ACSL1(13), ACSL3(10), ACSL4(24), ACSL5(18), ACSL6(13), ADIPOQ(3), ADIPOR1(2), ADIPOR2(9), AGRP(2), AKT1(8), AKT2(4), AKT3(8), CAMKK1(8), CAMKK2(6), CD36(7), CHUK(11), CPT1A(10), CPT1C(15), CPT2(7), G6PC(6), G6PC2(9), IKBKB(15), IRS1(17), IRS4(20), JAK1(31), JAK2(21), JAK3(9), LEP(2), LEPR(15), MAPK10(9), MAPK8(7), MAPK9(7), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NPY(2), PCK1(15), PCK2(7), POMC(2), PPARA(2), PPARGC1A(13), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKAG1(2), PRKAG2(4), PRKAG3(6), PRKCQ(13), PTPN11(8), RELA(6), RXRA(1), RXRG(10), SLC2A1(6), SLC2A4(4), STAT3(12), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5), TYK2(7)	28077242	570	96	548	169	126	240	83	29	76	16	0.00088	0.0038
145	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(6), CASP2(9), CHUK(11), CRADD(3), IKBKB(15), JUN(1), LTA(3), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K1(31), MAP3K14(12), MAP4K2(6), MAPK14(6), MAPK8(7), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNF(1), TNFRSF1A(6), TRAF2(5)	8049998	178	54	175	37	32	70	28	18	28	2	0.00092	0.0039
146	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(40), ASH2L(11), C17orf79(4), CARM1(6), CTCFL(15), DOT1L(8), EED(6), EHMT2(6), EZH1(11), EZH2(14), FBXO11(8), HCFC1(27), HSF4(2), JMJD4(3), JMJD6(3), KDM6A(10), MEN1(5), MLL(38), MLL2(64), MLL3(71), MLL4(53), MLL5(22), NSD1(36), OGT(19), PAXIP1(2), PPP1CA(6), PPP1CB(7), PPP1CC(2), PRDM2(23), PRDM9(28), PRMT1(7), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), RBBP5(9), SATB1(14), SETD1A(12), SETD2(31), SETD7(6), SETD8(3), SETDB1(19), SETDB2(12), SETMAR(6), SMYD3(4), STK38(7), SUV39H1(10), SUV39H2(6), SUV420H1(11), SUZ12(8), WHSC1(25), WHSC1L1(24)	40754041	794	110	767	181	185	298	116	34	140	21	0.00093	0.0039
147	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(2), AKT1(8), APC(53), ASAH1(9), CAMP(1), DAG1(7), DLG4(13), EPHB2(10), GNAI1(4), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), PITX2(10), PTX3(2), RHO(8), RYR1(80)	16262038	326	78	310	116	95	139	41	12	31	8	0.0012	0.0052
148	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(17), DYRK1B(4), GLI2(11), GLI3(21), GSK3B(11), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), SHH(7), SMO(6), SUFU(7)	5503931	113	45	110	50	32	44	6	3	24	4	0.0013	0.0052
149	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(8), AKT2(4), AKT3(8), ARHGEF11(22), CDC42(5), DLG4(13), GNA13(9), LPA(14), MAP2K4(6), MAP3K1(31), MAP3K5(21), MAPK8(7), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PDK1(7), PHKA2(15), PI3(3), PIK3CB(19), PLD1(16), PLD2(7), PLD3(3), PTK2(11), RDX(12), ROCK1(27), ROCK2(15), SERPINA4(8), SRF(3)	16795725	330	75	316	81	77	130	39	17	57	10	0.0013	0.0053
150	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADRB1(2), DRD1(6), DRD2(10), EGF(24), EGFR(20), GJA1(6), GJD2(8), GNA11(3), GNAI1(4), GNAI2(7), GNAI3(3), GNAS(25), GRB2(3), GRM1(22), GRM5(22), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), HTR2A(15), HTR2B(2), HTR2C(18), ITPR1(31), ITPR2(38), ITPR3(23), KRAS(29), MAP2K1(2), MAP2K5(2), MAP3K2(8), MAPK1(2), MAPK3(4), MAPK7(17), NPR1(14), NPR2(16), NRAS(10), PDGFB(4), PDGFC(4), PDGFD(6), PDGFRA(29), PDGFRB(12), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), PRKACA(4), PRKACB(2), PRKACG(6), PRKCA(10), PRKCG(10), PRKG1(9), PRKG2(10), PRKX(4), RAF1(7), SOS1(21), SOS2(22), SRC(2), TJP1(33), TUBA1A(5), TUBA1B(4), TUBA1C(9), TUBA3C(7), TUBA3D(5), TUBA3E(15), TUBA4A(7), TUBA8(11), TUBAL3(5), TUBB1(8), TUBB2A(4), TUBB2B(2), TUBB2C(1), TUBB4(9), TUBB4Q(4), TUBB6(4), TUBB8(3)	45084004	935	117	884	272	265	370	147	42	101	10	0.0014	0.0056
151	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(18), AMY2A(7), AMY2B(11), ENPP1(11), ENPP3(16), G6PC(6), GAA(5), GANAB(13), GBA3(9), GBE1(12), GCK(5), GPI(9), GUSB(5), GYS1(12), GYS2(19), HK1(13), HK2(8), HK3(12), MGAM(49), PGM1(9), PGM3(6), PYGB(10), PYGL(9), PYGM(10), RNPC3(7), SI(47), UCHL1(5), UCHL3(1), UGDH(3), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10), UXS1(5)	19445518	422	81	410	98	120	153	66	26	57	0	0.0015	0.0060
152	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(2), BAX(4), CASP8(21), CYCS(3), FADD(1), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK1(2), MAPK3(4), MAPK8(7), NFKB1(12), NSMAF(11), RAF1(7), RELA(6), RIPK1(8), SMPD1(12), TNFRSF1A(6), TRAF2(5)	7028273	150	52	146	24	30	47	28	10	33	2	0.0016	0.0065
153	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), AKAP1(8), AKAP10(7), AKAP11(32), AKAP12(20), AKAP3(15), AKAP4(1), AKAP5(2), AKAP6(30), AKAP7(4), AKAP8(2), AKAP9(57), ARHGEF1(11), CALM2(3), CALM3(1), CHMP1B(3), GNA11(3), GNA12(10), GNA13(9), GNA14(5), GNA15(1), GNAI2(7), GNAI3(3), GNAL(6), GNAO1(5), GNAZ(7), GNB1(3), GNB2(5), GNB3(4), GNB5(3), GNG12(2), GNG13(2), GNG3(3), GNG4(5), GNGT2(1), ITPR1(31), KCNJ3(15), KRAS(29), NRAS(10), PALM2(6), PDE1A(12), PDE1B(9), PDE1C(14), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE7A(3), PDE7B(4), PDE8A(7), PDE8B(20), PLCB3(9), PPP3CA(4), PPP3CC(6), PRKACA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCI(8), PRKCQ(13), PRKCZ(4), PRKD1(8), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(10), USP5(13)	40211511	776	110	729	268	219	298	122	41	85	11	0.0016	0.0065
154	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(5), IFNGR1(6), IFNGR2(4), JAK1(31), JAK2(21), STAT1(14)	2937549	81	34	72	18	14	19	13	5	18	12	0.0016	0.0066
155	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(7), ATF2(6), CALM2(3), CALM3(1), EGFR(20), ELK1(2), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(6), MAP3K1(31), MAPK1(2), MAPK3(4), MAPK8(7), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), PAK1(3), PRKCA(10), PTK2(11), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), SRC(2), SYT1(4)	11558518	206	65	200	65	53	74	26	17	32	4	0.0017	0.0068
156	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREB1(5), CREBBP(37), EP300(29), NCOA3(8), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), RARA(3), RXRA(1)	6964699	118	52	114	39	31	43	12	6	24	2	0.0017	0.0068
157	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(2), CHUK(11), ELK1(2), FOS(6), IKBKB(15), IRAK1(5), JUN(1), LY96(4), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K1(31), MAP3K14(12), MAP3K7(8), MAPK14(6), MAPK8(7), MYD88(1), NFKB1(12), NFKBIA(3), PPARA(2), RELA(6), TIRAP(3), TLR10(19), TLR2(12), TLR3(6), TLR4(14), TLR6(10), TLR7(15), TLR9(7), TRAF6(4)	12515474	247	65	243	60	57	90	42	20	34	4	0.0019	0.0073
158	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	ADAM17(11), APH1A(1), CREBBP(37), CTBP2(7), DLL1(8), DLL3(5), DLL4(2), DTX1(5), DTX2(4), DTX3(5), DTX3L(8), DTX4(7), DVL2(12), DVL3(7), EP300(29), HDAC1(4), HDAC2(5), HES1(1), JAG1(15), MAML1(8), MAML2(9), MAML3(16), MFNG(5), NCOR2(24), NCSTN(10), NOTCH2(17), NOTCH3(31), NOTCH4(15), NUMB(11), NUMBL(4), PSEN1(4), PSEN2(5), PTCRA(1), RBPJ(7), RBPJL(8), SNW1(5)	19803062	353	80	347	115	91	159	40	17	42	4	0.0021	0.0082
159	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(11), CREBBP(37), EP300(29), FADD(1), HDAC3(10), IKBKB(15), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF6(4)	7582992	146	51	141	43	27	59	25	7	28	0	0.0022	0.0084
160	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(10), EGF(24), EGFR(20), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(4), PTPRB(31), RAF1(7), RASA1(29), SHC1(11), SOS1(21), SPRY1(4), SPRY2(6), SPRY4(2), SRC(2)	8758872	178	58	173	42	45	65	29	9	26	4	0.0023	0.0088
161	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(10), CD28(6), CD3D(3), CSK(1), CTLA4(2), DAG1(7), EPHB2(10), FBXW7(34), GRAP2(3), GRB2(3), ITK(10), ITPKB(6), LCK(5), LCP2(7), MAPK1(2), NCK1(4), NFAT5(13), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PLCG1(12), PTPRC(15), RAF1(7), RASGRP1(8), RASGRP2(5), RASGRP3(8), RASGRP4(7), SOS1(21), SOS2(22), VAV1(16), ZAP70(10)	18814319	333	74	316	109	88	131	38	15	53	8	0.0024	0.0093
162	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CALM2(3), CALM3(1), CRKL(5), GRB2(3), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP3K1(31), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), PAK1(3), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), SRC(2), SYT1(4)	9197915	165	59	159	48	44	55	21	16	25	4	0.0025	0.0097
163	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(2), BAG4(4), CASP2(9), CASP3(4), CASP8(21), CRADD(3), DFFA(1), DFFB(3), FADD(1), JUN(1), LMNA(8), LMNB1(5), MADD(21), MAP2K4(6), MAP3K1(31), MAP3K7(8), MAPK8(7), PAK1(3), PAK2(6), PRKDC(70), RB1(31), RIPK1(8), SPTAN1(29), TNF(1), TNFRSF1A(6), TRAF2(5)	13556797	294	64	287	60	70	100	42	21	52	9	0.0028	0.011
164	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(12), JAK1(31), JAK2(21), JAK3(9), PIAS3(9), PTPRU(20), REG1A(4), SRC(2), STAT3(12)	5261824	122	44	113	28	23	41	16	6	24	12	0.0029	0.011
165	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(8), AKT2(4), AKT3(8), ASAH1(9), BRAF(12), DAG1(7), DRD2(10), EGFR(20), EPHB2(10), GRB2(3), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), KCNJ3(15), KCNJ5(6), KCNJ9(4), MAPK1(2), PI3(3), PIK3CB(19), PITX2(10), PLCB1(6), PLCB2(9), PLCB3(9), PLCB4(20), RAF1(7), RGS20(5), SHC1(11), SOS1(21), SOS2(22), SRC(2), STAT3(12), TERF2IP(4)	20426374	376	80	361	119	93	157	56	17	47	6	0.0029	0.011
166	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(9), ELK1(2), FOS(6), GRB2(3), IL2(4), IL2RA(3), IL2RB(6), IL2RG(11), JAK1(31), JAK3(9), JUN(1), LCK(5), MAP2K1(2), MAPK3(4), MAPK8(7), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5), SYK(6)	8110704	158	55	148	28	44	56	15	11	24	8	0.0032	0.012
167	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(6), BCR(6), BLNK(4), ELK1(2), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAP3K1(31), MAPK1(2), MAPK3(4), PAPPA(32), RPS6KA1(5), RPS6KA3(17), SHC1(11), SOS1(21), SYK(6), VAV1(16), VAV2(5), VAV3(13)	9933557	200	61	192	55	60	66	27	12	29	6	0.0039	0.015
168	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(37), EP300(29), LPL(11), NCOA1(17), NCOA2(16), PPARG(5), RXRA(1)	6354293	116	50	113	35	29	42	17	8	20	0	0.0040	0.015
169	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(8), BDKRB2(9), CALM2(3), CALM3(1), CHRM1(6), CHRNA1(6), FLT1(23), FLT4(10), KDR(23), NOS3(11), PDE2A(14), PDE3A(17), PDE3B(15), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKG1(9), PRKG2(10), RYR2(111), SLC7A1(6), SYT1(4), TNNI1(1)	13391409	320	66	310	104	76	137	42	15	39	11	0.0049	0.018
170	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(15), ESR2(8), PDE1A(12), PDE1B(9), PLCB1(6), PLCB2(9), PRL(6), VIP(2)	3710236	67	38	64	22	19	26	11	4	7	0	0.0056	0.020
171	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(11), CREBBP(37), DUSP1(2), EP300(29), IKBKB(15), IL1B(2), IL8(3), MAP2K3(8), MAP2K6(9), MAP3K14(12), MAP3K7(8), MAPK14(6), MYD88(1), NFKB1(12), NFKBIA(3), NR3C1(13), RELA(6), TGFBR1(8), TGFBR2(6), TLR2(12), TNF(1)	9997609	204	57	199	58	50	77	33	12	32	0	0.0058	0.021
172	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(11), ADRA1B(7), ADRB1(2), ADRB2(8), CHRM1(6), CHRM2(9), CHRM3(9), CHRM4(9), CHRM5(13), DRD1(6), DRD2(10), DRD3(5), DRD5(11), HRH1(9), HRH2(3), HTR1A(13), HTR1B(6), HTR1D(6), HTR1E(6), HTR1F(15), HTR2A(15), HTR2B(2), HTR2C(18), HTR4(7), HTR5A(9), HTR6(4), HTR7(4)	8011280	223	58	212	81	75	89	36	8	15	0	0.0058	0.021
173	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	242	ACVR1(9), ACVR1B(6), ACVR2A(14), ACVR2B(8), AMHR2(4), BMP2(5), BMP7(15), BMPR1A(8), BMPR1B(6), BMPR2(14), CCL1(1), CCL13(2), CCL14(1), CCL15(2), CCL16(1), CCL17(1), CCL18(2), CCL23(3), CCL24(3), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL5(4), CCL7(4), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CCR9(2), CD27(2), CD40(4), CD40LG(7), CD70(2), CLCF1(2), CNTF(3), CNTFR(2), CSF1(5), CSF1R(7), CSF2RA(9), CSF2RB(11), CSF3(1), CSF3R(11), CX3CL1(4), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL12(3), CXCL13(2), CXCL14(1), CXCL16(3), CXCL2(2), CXCL3(1), CXCL5(3), CXCL6(1), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(3), EDA(7), EDA2R(9), EGF(24), EGFR(20), EPO(2), EPOR(4), FAS(7), FASLG(6), FLT1(23), FLT3(9), FLT3LG(4), FLT4(10), GDF5(8), GH1(6), GH2(5), GHR(10), HGF(15), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNAR1(9), IFNAR2(8), IFNB1(4), IFNG(5), IFNGR1(6), IFNGR2(4), IFNK(2), IFNW1(2), IL10(4), IL10RA(7), IL10RB(9), IL11RA(7), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL13RA1(14), IL15(1), IL15RA(3), IL17RA(10), IL17RB(5), IL18(1), IL18R1(5), IL18RAP(12), IL19(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), IL1RAP(2), IL2(4), IL20(6), IL20RA(3), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(8), IL24(7), IL25(2), IL26(7), IL28A(2), IL28B(4), IL28RA(8), IL29(2), IL2RA(3), IL2RB(6), IL2RG(11), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL6ST(10), IL7(2), IL7R(9), IL8(3), INHBA(7), INHBB(3), INHBC(4), INHBE(7), KDR(23), KIT(28), KITLG(2), LEP(2), LEPR(15), LIF(3), LIFR(22), LTA(3), LTB(1), LTBR(7), MET(10), MPL(5), NGFR(4), OSM(3), OSMR(12), PDGFB(4), PDGFC(4), PDGFRA(29), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(3), PRL(6), PRLR(6), RELT(1), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TNF(1), TNFRSF10A(3), TNFRSF10B(5), TNFRSF10C(3), TNFRSF10D(10), TNFRSF11A(6), TNFRSF11B(6), TNFRSF13B(4), TNFRSF14(2), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(1), TNFRSF8(8), TNFRSF9(3), TNFSF10(1), TNFSF11(6), TNFSF12(4), TNFSF13B(3), TNFSF14(6), TNFSF15(3), TNFSF18(3), TNFSF4(5), TNFSF8(1), TPO(18), TSLP(2), VEGFA(1), VEGFB(2), VEGFC(7), XCL1(1), XCL2(1), XCR1(7)	60159885	1191	116	1157	360	341	459	162	64	161	4	0.0069	0.024
174	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(3), CCND1(10), CCNE2(6), CDK2(5), CDK4(4), CDKN1B(5), CDKN2A(1), E2F1(12), E2F2(1), E2F4(3), PRB1(4)	2867522	58	33	54	12	10	20	12	6	10	0	0.0074	0.026
175	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	ADRBK1(3), AKT1(8), AKT2(4), AKT3(8), DAG1(7), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), PDK1(7), PHKA2(15), PIK3CB(19), PITX2(10), PLD1(16), PLD2(7), PLD3(3), VN1R1(5)	15193469	246	68	238	77	63	109	29	10	33	2	0.0075	0.026
176	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(2), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CFLAR(7), DAXX(11), DFFA(1), DFFB(3), FADD(1), FAF1(8), JUN(1), LMNA(8), LMNB1(5), MAP2K4(6), MAP3K1(31), MAP3K7(8), MAPK8(7), PAK1(3), PAK2(6), PRKDC(70), PTPN13(27), RB1(31), RIPK2(7), SPTAN1(29)	14667430	315	64	307	61	78	104	47	21	54	11	0.0082	0.029
177	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(5), IFNGR1(6), JAK1(31), JAK2(21), PTPRU(20), REG1A(4), STAT1(14)	4004445	101	39	92	23	16	31	15	5	22	12	0.0083	0.029
178	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(54), BMPR1B(6), CCND2(7), CDK4(4), CDKN1B(5), DAZL(5), DMC1(8), EGR1(8), ESR2(8), FSHR(17), GJA4(2), INHA(3), LHCGR(16), MLH1(8), MSH5(15), NCOR1(24), NRIP1(18), PGR(9), PRLR(6), PTGER2(5), SMPD1(12), VDR(9), ZP2(15)	11973900	264	60	253	64	52	112	37	9	48	6	0.0095	0.033
179	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	126	ACTB(5), CHAD(3), COL11A1(36), COL11A2(13), COL17A1(24), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A1(33), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), COMP(7), DES(5), DSC2(17), DSC3(22), DSG1(18), DSG2(8), DSG4(18), FN1(39), GJA1(6), GJA10(7), GJA4(2), GJA8(6), GJA9(12), GJB1(1), GJB2(3), GJB3(2), GJB4(5), GJB5(3), GJB6(4), GJB7(8), GJC1(2), GJC3(4), GJD2(8), GJD4(3), IBSP(6), INA(2), ITGA6(12), ITGB4(12), KRT1(8), KRT10(1), KRT12(7), KRT13(9), KRT14(3), KRT15(10), KRT16(8), KRT17(4), KRT19(4), KRT2(9), KRT20(4), KRT23(9), KRT24(5), KRT25(6), KRT27(7), KRT28(5), KRT3(9), KRT31(12), KRT32(9), KRT33A(7), KRT33B(4), KRT34(9), KRT35(7), KRT36(7), KRT37(7), KRT38(9), KRT4(10), KRT5(6), KRT6A(5), KRT6B(10), KRT6C(6), KRT7(1), KRT71(5), KRT72(7), KRT73(4), KRT74(3), KRT75(7), KRT76(10), KRT77(4), KRT78(4), KRT79(5), KRT8(4), KRT81(5), KRT82(5), KRT83(3), KRT84(9), KRT85(5), KRT86(1), KRT9(13), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), LMNA(8), LMNB1(5), NES(31), PRPH(2), RELN(48), SPP1(3), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNC(19), TNN(16), TNR(16), TNXB(25), VIM(8), VWF(31)	78537790	1518	126	1482	477	426	632	200	71	156	33	0.011	0.037
180	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(3), EEF1B2(3), EEF1D(9), EEF1G(4), EEF2(8), EEF2K(11), EIF1AX(4), EIF2AK1(12), EIF2AK2(16), EIF2AK3(14), EIF2B1(1), EIF2B2(4), EIF2B3(8), EIF2B4(5), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF4A1(4), EIF4A2(6), EIF4E(4), EIF4EBP2(1), EIF4G1(15), EIF4G3(26), EIF5(3), EIF5A(7), EIF5B(17), ETF1(5), GSPT2(14), KIAA0664(12), PABPC1(11), PABPC3(13), PAIP1(4), SLC35A4(4)	14350994	266	75	260	60	70	108	37	11	36	4	0.011	0.037
181	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(5), GRIA2(25), PPP1R1B(4)	1220573	35	22	32	4	4	13	6	0	12	0	0.011	0.037
182	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	9	CREB1(5), FOS(6), JUN(1), KEAP1(8), MAPK1(2), MAPK14(6), MAPK8(7), NFE2L2(13), PRKCA(10)	2895007	58	33	55	10	9	21	12	7	9	0	0.011	0.037
183	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(5), BAD(2), CABIN1(15), CALM2(3), CALM3(1), CAMK2B(2), CAMK4(5), CD3E(2), CD3G(2), CD69(4), CDKN1A(1), CNR1(8), CREBBP(37), CSNK2A1(9), CTLA4(2), EGR2(8), EGR3(9), EP300(29), FCER1A(6), FCGR3A(2), FKBP1B(1), FOS(6), FOSL1(4), GATA3(4), GATA4(1), GSK3A(9), GSK3B(11), ICOS(2), IFNB1(4), IFNG(5), IL10(4), IL1B(2), IL2(4), IL2RA(3), IL6(2), IL8(3), ITK(10), KPNA5(6), MAPK14(6), MAPK8(7), MAPK9(7), MEF2A(5), MEF2B(3), MEF2D(7), MYF5(4), NCK2(8), NFAT5(13), NFATC2(15), NFATC3(12), NFATC4(8), NFKB2(10), NFKBIB(3), NFKBIE(6), NPPB(2), NUP214(20), OPRD1(2), P2RX7(3), PAK1(3), PIN1(1), PPIA(2), PPP3CB(7), PPP3CC(6), PPP3R1(2), PTPRC(15), RELA(6), SLA(9), SP1(6), SP3(12), TGFB1(4), TNF(1), TRAF2(5), TRPV6(14), VAV1(16), VAV2(5), VAV3(13), XPO5(10)	30824308	511	91	497	172	141	198	65	24	81	2	0.012	0.039
184	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(14), IL13RA2(3), IL4R(6), JAK1(31), JAK2(21), TYK2(7)	3662914	82	34	74	19	12	20	14	7	17	12	0.012	0.041
185	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(14), IL13RA2(3), IL4R(6), JAK1(31), JAK2(21), TYK2(7)	3662914	82	34	74	19	12	20	14	7	17	12	0.012	0.041
186	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), PRKCE(11), SOD1(2)	2802036	83	35	78	32	30	30	9	4	10	0	0.013	0.042
187	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8)	907722	21	16	21	6	1	13	1	0	6	0	0.013	0.042
188	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(31), JAK2(21), JAK3(9), MAPK1(2), MAPK3(4), STAT3(12), TYK2(7)	4046509	86	36	78	25	12	28	11	6	17	12	0.013	0.042
189	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(24), C5(20), C6(23), C7(21), C8A(12), C9(20)	4324705	120	39	114	23	25	45	22	7	17	4	0.014	0.044
190	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(31), JAK2(21), JAK3(9), PIAS1(5), PIAS3(9), PTPRU(20), REG1A(4), SOAT1(10)	4821347	109	41	100	25	21	38	13	6	19	12	0.014	0.044
191	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(21), GABBR1(17), GPRC5A(5), GPRC5B(8), GPRC5C(4), GPRC5D(4), GRM1(22), GRM2(7), GRM3(20), GRM4(16), GRM5(22), GRM7(15), GRM8(24)	7183145	185	52	179	57	63	55	32	7	26	2	0.014	0.045
192	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(8), CD8A(3), CSF1(5), CSF3(1), EPO(2), IL2(4), IL5(2), IL6(2), IL7(2), IL8(3)	2125427	32	25	32	12	12	10	4	0	6	0	0.014	0.046
193	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(5), GRB2(3), HBXIP(1), PTK2B(16), SHC1(11), SOS1(21), SRC(2)	2976267	59	33	57	15	15	28	6	4	4	2	0.015	0.046
194	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(11), IFNB1(4), IKBKB(15), IL1A(1), IL1B(2), IL1R1(5), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(5), IRAK2(7), IRAK3(13), JUN(1), MAP2K3(8), MAP2K6(9), MAP3K1(31), MAP3K14(12), MAP3K7(8), MAPK14(6), MAPK8(7), MYD88(1), NFKB1(12), NFKBIA(3), RELA(6), TGFB1(4), TGFB2(6), TGFB3(9), TNF(1), TRAF6(4)	10060705	196	55	190	46	41	82	30	14	27	2	0.015	0.048
195	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(8), CSF1(5), CSF3(1), HLA-DRB1(1), IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL15(1), IL1A(1), IL2(4), IL5(2), IL6(2), IL7(2), IL8(3), LTA(3), TGFB1(4), TGFB2(6), TGFB3(9), TNF(1)	4610788	76	39	74	27	23	34	10	1	8	0	0.016	0.051
196	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(17), CD3D(3), CD3E(2), CD3G(2), CD4(8), CREBBP(37), CSK(1), GNAS(25), GNB1(3), HLA-DRB1(1), LCK(5), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PTPRC(15), ZAP70(10)	7527066	158	53	153	47	38	74	13	8	23	2	0.018	0.056
197	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(17), CD3D(3), CD3E(2), CD3G(2), CD4(8), CREBBP(37), CSK(1), GNAS(25), GNB1(3), HLA-DRB1(1), LCK(5), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PTPRC(15), ZAP70(10)	7527066	158	53	153	47	38	74	13	8	23	2	0.018	0.056
198	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(21), AR(5), ESR1(15), ESR2(8), ESRRA(2), HNF4A(15), NPM1(3), NR0B1(8), NR1D1(3), NR1D2(5), NR1H2(4), NR1H3(5), NR1I2(5), NR1I3(7), NR2C2(8), NR2E1(6), NR2F1(5), NR2F2(6), NR3C1(13), NR4A1(4), NR4A2(13), NR5A2(14), PGR(9), PPARA(2), PPARD(6), PPARG(5), RARA(3), RARB(6), RARG(6), ROR1(11), RORA(9), RORC(8), RXRA(1), RXRG(10), THRA(5), THRB(4), VDR(9)	14060609	269	66	257	77	81	114	33	17	22	2	0.018	0.057
199	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(3), CDC40(8), CLK2(10), CLK3(5), CLK4(6), COL2A1(14), CPSF1(9), CPSF2(10), CPSF3(8), CPSF4(3), CSTF1(4), CSTF2(12), CSTF2T(8), CSTF3(12), DDIT3(1), DDX1(6), DDX20(6), DHX15(10), DHX16(16), DHX38(14), DHX8(10), DHX9(18), DICER1(39), DNAJC8(1), FUS(3), GIPC1(1), METTL3(8), NCBP1(9), NCBP2(4), NONO(15), NXF1(4), PABPN1(4), PAPOLA(10), PHF5A(1), POLR2A(25), PPM1G(7), PRPF18(4), PRPF3(11), PRPF4(6), PRPF4B(25), PRPF8(27), PSKH1(6), PTBP1(2), PTBP2(6), RBM17(9), RBM5(5), RNGTT(13), RNMT(7), RNPS1(1), SF3A1(9), SF3A3(6), SF3B1(18), SF3B2(10), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(3), SNRPB2(1), SNRPD1(1), SNRPD2(2), SNRPD3(2), SNRPE(2), SNRPG(1), SPOP(19), SRPK1(14), SRPK2(7), SRRM1(10), SUPT5H(20), U2AF1(3), U2AF2(6), XRN2(14)	36318201	602	101	583	169	178	225	83	42	70	4	0.019	0.058
200	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(4), CASP8(21), CFL1(1), CFLAR(7), PDE6D(1)	1303506	34	21	33	7	5	13	6	1	9	0	0.021	0.066
201	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(11), DUSP1(2), IKBKAP(14), IKBKB(15), LTA(3), MAP3K1(31), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFAIP3(2), TNFRSF1B(3), TRAF1(5), TRAF2(5), TRAF3(6)	7832986	142	47	139	35	29	56	17	13	25	2	0.022	0.067
202	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	ATF2(6), BRAF(12), CHUK(11), CREB1(5), DAXX(11), ELK1(2), FOS(6), GRB2(3), IKBKB(15), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K5(2), MAP2K6(9), MAP3K1(31), MAP3K10(7), MAP3K11(5), MAP3K12(8), MAP3K13(13), MAP3K14(12), MAP3K2(8), MAP3K3(9), MAP3K4(23), MAP3K5(21), MAP3K6(7), MAP3K7(8), MAP3K8(12), MAP3K9(6), MAP4K1(13), MAP4K2(6), MAP4K3(21), MAP4K4(14), MAP4K5(7), MAPK1(2), MAPK10(9), MAPK13(2), MAPK14(6), MAPK3(4), MAPK4(6), MAPK6(11), MAPK7(17), MAPK8(7), MAPK9(7), MAPKAPK2(6), MAPKAPK3(4), MAPKAPK5(6), MAX(8), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MKNK1(6), MKNK2(4), MYC(7), NFKB1(12), NFKBIA(3), PAK1(3), PAK2(6), RAF1(7), RELA(6), RIPK1(8), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA4(5), RPS6KA5(7), RPS6KB1(3), RPS6KB2(6), SHC1(11), SP1(6), STAT1(14), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TRAF2(5)	31929205	635	97	619	151	149	261	84	40	95	6	0.022	0.068
203	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(13), CD14(2), CD19(7), CD1A(5), CD1B(3), CD1C(15), CD1D(3), CD1E(6), CD2(4), CD22(13), CD33(11), CD34(4), CD36(7), CD37(1), CD38(7), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD44(12), CD5(7), CD55(6), CD59(2), CD8A(3), CD8B(1), CD9(4), CR1(28), CR2(28), CSF1(5), CSF1R(7), CSF2RA(9), CSF3(1), CSF3R(11), DNTT(6), EPO(2), EPOR(4), FCER2(2), FCGR1A(7), FLT3(9), FLT3LG(4), GP1BA(11), GP5(5), GYPA(2), HLA-DRB1(1), HLA-DRB5(1), IL11RA(7), IL1A(1), IL1B(2), IL1R1(5), IL1R2(7), IL2RA(3), IL3RA(11), IL4R(6), IL5(2), IL5RA(9), IL6(2), IL6R(12), IL7(2), IL7R(9), ITGA1(20), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGAM(24), ITGB3(16), KIT(28), KITLG(2), MME(8), MS4A1(6), TFRC(6), THPO(11), TNF(1), TPO(18)	29103747	586	92	569	185	170	221	78	27	84	6	0.022	0.068
204	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(11), DAXX(11), EGF(24), EGFR(20), ETS1(6), ETS2(5), FOS(6), HOXA7(8), IKBKB(15), JUN(1), MAP2K1(2), MAP2K3(8), MAP2K4(6), MAP2K6(9), MAP3K1(31), MAP3K14(12), MAP3K5(21), MAPK1(2), MAPK13(2), MAPK14(6), MAPK3(4), MAPK8(7), NFKB1(12), NFKBIA(3), PPP2CA(6), PRKCA(10), PRKCD(7), PRKCE(11), PRKCG(10), PRKCH(9), PRKCQ(13), RAF1(7), RELA(6), RIPK1(8), SP1(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	16685307	340	69	333	95	80	136	56	22	44	2	0.023	0.069
205	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(9), LPO(6), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), TPO(18), TYR(10)	3243469	76	36	75	23	27	31	10	1	7	0	0.023	0.069
206	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(3), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADK(1), ADSL(7), ADSS(8), AK1(2), AK2(4), AK5(6), ALLC(10), AMPD1(21), AMPD2(9), AMPD3(4), ATIC(9), ATP1B1(3), ATP5A1(11), ATP5B(4), ATP5C1(1), ATP5F1(5), ATP5G1(4), ATP5G2(1), ATP5I(1), ATP5J(4), CANT1(5), DCK(4), DGUOK(3), ENPP1(11), ENPP3(16), ENTPD1(6), FHIT(2), GART(8), GDA(5), GMPS(13), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(10), ITPA(1), NPR1(14), NPR2(16), NT5C(1), NT5E(6), NT5M(4), NUDT2(3), PAICS(4), PAPSS1(6), PAPSS2(6), PDE1A(12), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE5A(14), PDE6B(6), PDE6C(14), PDE7B(4), PDE8A(7), PDE9A(10), PFAS(10), PKLR(10), PKM2(5), POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), PPAT(10), PRPS1(3), PRPS1L1(5), PRPS2(10), PRUNE(4), RRM1(4), RRM2(5)	42966703	763	100	751	225	195	326	98	46	96	2	0.024	0.073
207	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(17), AP2A1(7), AP2M1(6), BIN1(3), CALM2(3), CALM3(1), DNM1(5), EPN1(9), EPS15(12), PICALM(13), PPP3CA(4), PPP3CB(7), PPP3CC(6), SYNJ1(27), SYNJ2(13), SYT1(4)	7528739	137	52	133	51	38	48	24	7	20	0	0.025	0.074
208	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(4), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), XYLT1(15), XYLT2(9)	2082646	44	27	43	16	14	19	5	1	5	0	0.025	0.075
209	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(4), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), XYLT1(15), XYLT2(9)	2082646	44	27	43	16	14	19	5	1	5	0	0.025	0.075
210	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR2(8), ATP8A1(14), AVPR1A(8), AVPR1B(3), AVPR2(5), BDKRB1(5), BDKRB2(9), BRS3(13), C3AR1(7), CCKAR(12), CCKBR(7), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR6(5), CCR7(5), CCR8(6), CX3CR1(4), CXCR3(5), CXCR4(1), CXCR6(3), EDNRA(6), EDNRB(2), FPR1(4), FSHR(17), GALR1(2), GALR3(3), GALT(2), GHSR(7), GNB2L1(2), GNRHR(4), GPR77(3), GRPR(4), LHCGR(16), MC2R(2), MC3R(8), MC4R(7), MC5R(12), NMBR(4), NPY1R(6), NPY2R(4), NPY5R(10), NTSR1(4), NTSR2(2), OPRD1(2), OPRK1(9), OPRM1(11), OXTR(4), PPYR1(7), SSTR1(12), SSTR2(3), SSTR3(6), SSTR4(12), TAC4(1), TACR1(6), TACR2(4), TACR3(9), TRHR(5), TSHR(12)	17007718	375	72	368	138	96	174	50	15	40	0	0.026	0.076
211	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(21), BDKRB1(5), BDKRB2(9), C1QA(6), C1QB(3), C1QC(6), C1R(15), C1S(9), C2(6), C3(24), C3AR1(7), C4BPA(8), C4BPB(4), C5(20), C5AR1(5), C6(23), C7(21), C8A(12), C8B(4), C9(20), CD46(1), CD55(6), CD59(2), CFB(8), CFH(17), CFI(9), CPB2(7), CR1(28), CR2(28), F10(10), F11(10), F12(3), F13A1(10), F13B(13), F2(9), F2R(8), F3(6), F5(46), F7(2), F8(41), F9(11), FGA(30), FGB(6), FGG(12), KLKB1(13), KNG1(8), MASP1(14), MASP2(6), MBL2(3), PLAT(6), PLAU(5), PLAUR(5), PLG(13), PROC(7), SERPINA1(4), SERPINA5(3), SERPINC1(9), SERPIND1(6), SERPINE1(5), SERPINF2(5), SERPING1(7), TFPI(11), VWF(31)	31318799	712	92	682	185	196	299	93	35	81	8	0.029	0.085
212	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), NAT1(10), NAT2(3), XDH(10)	2863937	52	32	48	21	18	25	5	1	3	0	0.030	0.088
213	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(9), IFNB1(4), JAK1(31), PTPRU(20), REG1A(4), STAT1(14), STAT2(12), TYK2(7)	4324227	101	39	92	25	20	37	14	6	18	6	0.032	0.092
214	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(5), ALG6(5), CCKBR(7), CCR2(6), CCR3(5), CELSR2(30), CELSR3(23), CHRM2(9), CHRM3(9), CIDEB(3), CXCR3(5), EDNRA(6), EMR2(5), EMR3(8), F2R(8), FSHR(17), GHRHR(2), GNRHR(4), GPR116(20), GPR132(8), GPR133(11), GPR143(13), GPR17(4), GPR18(2), GPR55(4), GPR56(3), GPR61(7), GPR77(3), GPR84(6), GRM1(22), GRPR(4), HRH4(4), LGR6(18), LPHN2(30), LPHN3(29), LTB4R2(3), NTSR1(4), OR8G1(1), OR8G2(6), P2RY11(7), P2RY13(3), PTGFR(10), SMO(6), SSTR2(3), TAAR5(8), TSHR(12), VN1R1(5)	20282496	413	80	408	120	119	165	59	26	42	2	0.032	0.093
215	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(11), GOT1(6), GOT2(5), TAT(9), TYR(10)	1635238	41	24	40	5	8	17	7	3	6	0	0.035	0.100
216	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(12), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), DDC(11), EPX(14), GOT1(6), GOT2(5), HPD(7), LPO(6), MAOA(14), MAOB(7), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), TAT(9), TPO(18)	7537821	167	50	162	51	48	66	23	8	22	0	0.036	0.10
217	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(9), BAIAP2(1), CASP1(7), CASP3(4), CASP7(4), CASP8(21), GAPDH(2), INSR(18), ITCH(8), MAGI1(32), MAGI2(26), RERE(14), WWP1(18), WWP2(7)	8025142	171	52	168	43	35	83	24	6	23	0	0.037	0.10
218	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(2), ACP5(4), ACPP(5), ACPT(7), ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), CYP19A1(12), CYP1A1(9), CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2D6(2), CYP2E1(5), CYP2F1(5), CYP2J2(5), CYP3A4(14), CYP3A5(7), CYP3A7(9), CYP4B1(4), CYP4F8(9), CYP51A1(4), PON1(12)	10164909	195	55	190	60	57	74	31	11	20	2	0.039	0.11
219	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(6), BAD(2), BRAF(12), CREB1(5), CREB3(2), CREB5(6), DUSP4(1), DUSP6(1), DUSP9(8), EEF2K(11), EIF4E(4), GRB2(3), MAP2K1(2), MAP3K8(12), MAPK1(2), MAPK3(4), MKNK1(6), MKNK2(4), MOS(8), NFKB1(12), RAP1A(3), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), SHC1(11), SOS1(21), SOS2(22), TRAF3(6)	9970363	212	59	204	48	42	91	32	12	31	4	0.040	0.11
220	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABARAP(2), GABRA1(10), GABRA2(12), GABRA3(15), GABRA4(17), GABRA5(8), GABRA6(8), GPHN(13), NSF(3), SRC(2), UBQLN1(8)	4203532	103	40	97	33	31	41	12	6	13	0	0.041	0.12
221	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD4(8), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15), THY1(1)	3855787	71	36	70	29	14	38	7	2	10	0	0.042	0.12
222	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(11), FADD(1), IKBKB(15), IL1A(1), IL1R1(5), IRAK1(5), MAP3K1(31), MAP3K14(12), MAP3K7(8), MYD88(1), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), TLR4(14), TNF(1), TNFAIP3(2), TNFRSF1A(6), TNFRSF1B(3), TRAF6(4)	8233550	149	49	146	41	34	54	21	13	25	2	0.042	0.12
223	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(11), CALM2(3), CALM3(1), CD79A(1), CD79B(2), ELK1(2), FOS(6), GRB2(3), JUN(1), LYN(7), MAP2K1(2), MAP3K1(31), MAPK14(6), MAPK3(4), MAPK8(7), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), RAF1(7), SHC1(11), SOS1(21), SYK(6), SYT1(4), VAV1(16)	13078319	230	64	222	66	72	74	31	16	31	6	0.042	0.12
224	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(7), IFNG(5), IL12A(7), IL12B(3), IL18(1), IL2(4)	1094142	27	20	26	7	9	8	5	2	3	0	0.043	0.12
225	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(3), CALM3(1), CHUK(11), EGR2(8), EGR3(9), MAP3K1(31), MYC(7), NFATC2(15), NFKB1(12), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), RELA(6), SYT1(4), VIP(2)	9279653	170	52	164	51	39	62	22	14	29	4	0.044	0.12
226	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(4), GBA3(9), LPO(6), MPO(9), PRDX6(2), TPO(18)	2853182	62	34	61	20	25	21	7	2	7	0	0.045	0.12
227	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(4), ARSB(6), FUCA1(3), FUCA2(3), GBA(4), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), HGSNAT(9), HPSE(4), HPSE2(5), HYAL1(4), HYAL2(1), IDS(6), LCT(30), MAN2B1(20), MAN2B2(9), MAN2C1(8), MANBA(14), NAGLU(3), NEU2(5), NEU3(3), SPAM1(12)	11375922	176	58	171	72	49	79	21	11	16	0	0.045	0.12
228	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(24), C5(20), C6(23), C7(21), ICAM1(3), IL1A(1), IL6(2), IL8(3), ITGA4(12), ITGAL(13), ITGB1(12), ITGB2(14), SELP(15), SELPLG(11), TNF(1), VCAM1(9)	8463946	184	52	176	47	44	82	19	9	26	4	0.046	0.12
229	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(10), ABAT(9), ADSL(7), ADSS(8), AGXT(5), AGXT2(9), ASL(4), ASNS(9), ASPA(5), CAD(38), CRAT(3), DARS(4), DDO(9), GAD1(8), GAD2(12), GOT1(6), GOT2(5), GPT2(7), NARS(7), PC(8)	8647259	173	56	171	51	40	77	26	5	25	0	0.047	0.13
230	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(7), CR1(28), CR2(28), FCGR2B(4), HLA-DRB1(1), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15)	5313926	113	43	110	35	34	47	14	4	12	2	0.051	0.14
231	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(4), EGFR(20), ELK1(2), GNAS(25), GNB1(3), GRB2(3), IGF1R(13), ITGB1(12), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(4), MKNK1(6), MKNK2(4), MYC(7), NGFR(4), PDGFRA(29), PPP2CA(6), PTPRR(18), RAF1(7), RPS6KA1(5), RPS6KA5(7), SHC1(11), SOS1(21), SRC(2), STAT3(12)	10992088	231	61	223	50	56	98	32	12	29	4	0.051	0.14
232	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(17), GNAS(25), GNB1(3), PRKACA(4), PRKAR1A(4)	2068545	53	29	51	10	14	27	3	4	5	0	0.053	0.14
233	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(4), BIRC2(13), BIRC3(3), CASP3(4), CASP8(21), CFLAR(7), FADD(1), JUN(1), MAP2K4(6), MAP3K3(9), MAP3K7(8), NFKB1(12), NFKB2(10), NFKBIA(3), NFKBIB(3), NFKBIE(6), NFKBIL1(2), NR2C2(8), RALBP1(7), RIPK1(8), TNF(1), TNFAIP3(2), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	8982098	153	53	149	36	32	64	25	6	26	0	0.054	0.14
234	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(8), AP2A1(7), AP2M1(6), ARF1(4), BAD(2), BTK(11), EEA1(20), GRASP(3), GSK3A(9), GSK3B(11), LYN(7), PDPK1(3), PFKM(7), PFKP(11), PLCG1(12), PRKCE(11), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(5)	8006261	146	52	138	54	43	60	19	7	17	0	0.055	0.14
235	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(14), LPO(6), MPO(9), MTHFR(7), PRDX6(2), SHMT1(6), SHMT2(8), TPO(18)	3889486	78	37	77	19	26	30	7	2	11	2	0.056	0.15
236	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(1), ANXA3(8), ANXA4(8), ANXA5(3), ANXA6(10), CYP11A1(10), EDN1(2), EDNRA(6), EDNRB(2), HPGD(2), HSD11B1(4), PLA2G4A(11), PRL(6), PTGDR(6), PTGDS(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3), PTGIS(8), PTGS1(8), PTGS2(7), SCGB1A1(1), TBXAS1(6)	7229033	145	48	144	43	45	54	19	7	20	0	0.056	0.15
237	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(5), CD4(8), HLA-DRB1(1), IL1B(2), IL5(2), IL5RA(9), IL6(2)	1925145	29	21	27	11	3	15	1	0	10	0	0.058	0.15
238	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(5), BMP4(7), BMP5(16), BMP6(6), BMP7(15), BMP8A(3), BMP8B(1), BTRC(13), CSNK1A1(5), CSNK1A1L(4), CSNK1E(10), CSNK1G1(8), CSNK1G3(11), DHH(2), FBXW11(5), GLI1(12), GLI2(11), GLI3(21), GSK3B(11), HHIP(12), IHH(3), LRP2(72), PRKACA(4), PRKACB(2), PRKACG(6), PRKX(4), PTCH1(23), PTCH2(21), RAB23(4), SHH(7), SMO(6), STK36(11), SUFU(7), WNT1(1), WNT10A(4), WNT10B(1), WNT11(4), WNT16(6), WNT2(4), WNT2B(9), WNT3(5), WNT4(4), WNT5A(9), WNT5B(4), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(4), WNT9A(1), WNT9B(1), ZIC2(1)	19982790	410	78	395	130	131	163	46	14	54	2	0.059	0.15
239	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(4)	181162	4	4	4	1	2	1	0	0	1	0	0.060	0.15
240	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(10), CTH(5), GOT1(6), GOT2(5), LDHA(6), LDHB(2), LDHC(3)	2295356	37	28	36	17	8	14	3	4	8	0	0.060	0.15
241	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(10), GLS2(9), GLUD1(4), GLUD2(9)	1451447	32	21	31	11	8	12	5	1	6	0	0.061	0.16
242	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(2), CAT(5), EPX(14), LPO(6), MPO(9), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), SHMT1(6), SHMT2(8), TPO(18)	3906933	81	38	80	23	28	34	7	2	8	2	0.063	0.16
243	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(7), GSTZ1(4)	463421	11	10	11	1	0	6	1	2	2	0	0.064	0.16
244	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(9), IFNAR2(8), IFNB1(4), JAK1(31), STAT1(14), STAT2(12), TYK2(7)	3819937	85	33	75	21	17	25	14	7	16	6	0.065	0.16
245	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(24), EGFR(20), MAP2K1(2), MAP3K1(31), MAPK14(6), NCOR2(24), RARA(3), RXRA(1), THRA(5), THRB(4)	5296718	120	42	116	36	33	41	16	11	17	2	0.068	0.17
246	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(3), ALOX12(6), ALOX12B(10), ALOX15(12), ALOX15B(12), ALOX5(7), CBR1(2), CBR3(2), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2J2(5), CYP2U1(2), CYP4A11(5), CYP4A22(8), CYP4F2(11), CYP4F3(8), EPHX2(7), GGT1(10), GPX3(4), GPX5(7), GPX6(6), GPX7(1), LTA4H(6), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PTGDS(6), PTGES(2), PTGES2(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6)	12931334	248	63	242	75	67	103	34	13	29	2	0.070	0.17
247	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(4), FDFT1(3), FDPS(7), HMGCR(15), HMGCS1(4), IDI1(4), MVD(3), MVK(7), NSDHL(9), PMVK(2), SC4MOL(3), SC5DL(3), SQLE(6)	4147606	74	36	73	29	19	22	12	7	14	0	0.070	0.17
248	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(5), CREM(5), FOS(6), JUN(1), MAPK3(4), OPRK1(9), POLR2A(25), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5)	4326378	84	38	82	22	17	42	7	5	11	2	0.071	0.18
249	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(3), IL10(4), IL10RA(7), IL10RB(9), IL1A(1), IL6(2), JAK1(31), STAT1(14), STAT3(12), STAT5A(5), TNF(1)	4269018	92	35	84	26	20	34	9	3	20	6	0.071	0.18
250	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(6), ALOX15(12), ALOX5(7), CBR1(2), CBR3(2), CYP4F2(11), CYP4F3(8), EPX(14), GGT1(10), LPO(6), LTA4H(6), MPO(9), PLA2G1B(1), PLA2G2E(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PRDX1(1), PRDX2(4), PRDX5(3), PRDX6(2), PTGDS(6), PTGES2(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6), TPO(18)	9229941	189	55	185	61	55	83	26	7	18	0	0.073	0.18
251	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(7), GNAS(25), GNB1(3), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10)	3037929	74	34	70	21	18	35	5	4	10	2	0.077	0.19
252	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(11), MAP3K14(12), MAPK14(6), MAPK8(7), NFKB1(12), RELA(6), TNFRSF13B(4), TNFRSF17(2), TNFSF13B(3), TRAF2(5), TRAF3(6), TRAF5(8), TRAF6(4)	4964508	86	39	85	19	18	33	14	4	17	0	0.079	0.19
253	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX15(12), ALOX5(7), CYP1A2(6), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2J2(5), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	8182643	153	51	150	44	37	60	25	8	23	0	0.079	0.19
254	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(19), ARHGAP5(24), ARHGDIB(2), CASP1(7), CASP10(10), CASP3(4), CASP8(21), CASP9(3), CYCS(3), GZMB(2), JUN(1), PRF1(8)	4567768	104	37	100	21	25	33	16	4	24	2	0.080	0.19
255	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(7), CDO1(4), CSAD(10), GAD1(8), GAD2(12), GGT1(10)	2029827	51	28	50	9	15	13	16	1	6	0	0.080	0.19
256	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12), C9(20)	6178389	159	43	152	39	31	66	26	9	23	4	0.082	0.20
257	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(4), CD3D(3), CD3E(2), CD3G(2), CD4(8), CD58(1), CD8A(3), CSF3(1), IL6(2), IL8(3), KITLG(2)	2198083	35	23	35	8	6	18	3	0	8	0	0.084	0.20
258	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(12), GAD1(8), HDC(10), PNMT(3), TPH1(14)	1856313	47	27	46	7	12	18	9	1	5	2	0.089	0.21
259	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	12	NDUFA1(1), NDUFA10(8), NDUFA4(2), NDUFA5(7), NDUFA8(6), NDUFB5(2), NDUFB6(1), NDUFS1(13), NDUFS2(5), NDUFV1(4), NDUFV2(3)	2258789	52	27	51	15	14	25	4	3	6	0	0.090	0.21
260	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(8), ARSB(6), ARSD(9), ARSE(7), CYP11B1(6), CYP11B2(7), HSD11B1(4), HSD17B2(3), HSD17B3(6), HSD17B8(2), HSD3B1(1), HSD3B2(5), SRD5A1(4), SRD5A2(4), STS(9), SULT1E1(13), SULT2A1(7), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10)	9296383	176	53	167	51	50	70	22	14	20	0	0.091	0.21
261	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(7), HSD3B7(3), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	1650056	31	23	31	8	10	15	3	1	2	0	0.092	0.22
262	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(10), AARS2(13), ABAT(9), ACY3(4), ADSL(7), ADSS(8), ADSSL1(6), AGXT(5), AGXT2(9), ASL(4), ASNS(9), ASPA(5), ASRGL1(2), ASS1(3), CAD(38), CRAT(3), DARS(4), DARS2(7), DDO(9), DLAT(2), DLD(7), GAD1(8), GAD2(12), GOT1(6), GOT2(5), GPT2(7), NARS(7), NARS2(7), PC(8), PDHA1(4), PDHA2(10), PDHB(7)	12629716	245	64	241	82	60	102	37	10	36	0	0.092	0.22
263	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(4), C1GALT1C1(5), GALNT1(8), GALNT10(5), GALNT11(14), GALNT12(2), GALNT13(19), GALNT14(11), GALNT2(8), GALNT3(10), GALNT4(8), GALNT5(7), GALNT6(2), GALNT7(11), GALNT8(13), GALNTL1(12), GALNTL2(13), GALNTL4(6), GALNTL5(10), GCNT1(8), GCNT3(7), GCNT4(1), OGT(19), ST3GAL1(2), ST3GAL2(4), ST6GALNAC1(4), WBSCR17(14)	11174445	229	61	220	71	57	88	38	14	32	0	0.096	0.23
264	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(12), AGXT(5), AGXT2(9), AKR1B10(4), ALAS1(12), ALAS2(11), AMT(5), AOC2(6), AOC3(14), BHMT(2), CBS(13), CHDH(5), CHKA(8), CTH(5), DAO(5), DLD(7), DMGDH(6), GARS(8), GATM(8), GLDC(20), GNMT(3), HSD3B7(3), MAOA(14), MAOB(7), PEMT(2), PHGDH(7), PIPOX(6), PISD(5), PSAT1(5), PSPH(1), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SARDH(9), SARS(4), SARS2(7), SDS(3), SHMT1(6), SHMT2(8), TARS(10), TARS2(10)	14500847	292	61	284	87	80	123	40	12	35	2	0.097	0.23
265	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCL4(1), CCR1(5), CCR2(6), CCR3(5), CCR4(5), CCR7(5), CD28(6), CD4(8), CXCR3(5), CXCR4(1), IFNG(5), IFNGR1(6), IFNGR2(4), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18R1(5), IL2(4), IL4R(6), IL5(2), TGFB1(4), TGFB2(6), TGFB3(9)	6817236	136	47	134	45	27	63	15	8	23	0	0.098	0.23
266	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(4), DCN(11), FMOD(5), KERA(8), LUM(12)	1308286	40	21	37	12	12	14	3	2	9	0	0.10	0.23
267	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(4), B4GALT7(4), CHPF(5), CHST11(9), CHST12(5), CHST14(2), CHST3(4), CHST7(4), CHSY1(1), DSE(17), UST(4), XYLT1(15), XYLT2(9)	4638512	88	36	86	40	24	39	15	2	8	0	0.10	0.23
268	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(6), CHUK(11), IFNG(5), IKBKB(15), IL2(4), JUN(1), MAP3K1(31), MAP3K5(21), MAP4K5(7), MAPK14(6), MAPK8(7), NFKB1(12), NFKBIA(3), RELA(6), TNFRSF9(3), TRAF2(5)	6841853	143	41	137	37	33	55	18	11	24	2	0.10	0.23
269	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(11), DUSP1(2), IKBKAP(14), IKBKB(15), MAP3K1(31), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), TNFAIP3(2), TRAF3(6), TRAF6(4)	6332305	118	41	115	27	24	44	16	11	21	2	0.10	0.24
270	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(2), ACP5(4), ACPP(5), ACPT(7), ENPP1(11), ENPP3(16), FLAD1(8), RFK(2), TYR(10)	3401209	69	32	69	20	17	26	15	6	5	0	0.10	0.24
271	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2)	3981262	77	35	76	25	19	31	7	6	14	0	0.11	0.24
272	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(4), ACTA2(7), ACTN2(9), ACTN3(10), ACTN4(11), DES(5), DMD(83), FAM48A(7), MYBPC1(20), MYBPC2(9), MYBPC3(14), MYH3(30), MYH6(23), MYH7(28), MYH8(35), MYL1(7), MYL2(1), MYL4(1), MYL9(3), MYOM1(34), NEB(127), TMOD1(2), TNNC2(4), TNNI1(1), TNNI3(5), TNNT1(5), TNNT2(8), TPM1(2), TPM2(1), TPM3(6), TPM4(6), TTN(652), VIM(8)	49100638	1168	105	1133	243	337	414	192	62	64	99	0.11	0.25
273	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(1), ACTR2(7), ACTR3(3), AKT1(8), ANGPTL2(9), CDC42(5), CFL1(1), CFL2(8), FLNA(31), FLNC(34), FSCN1(2), FSCN3(5), GDI1(4), GDI2(3), LIMK1(7), MYH2(37), MYLK(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PAK7(12), PFN1(1), PFN2(3), RHO(8), ROCK1(27), ROCK2(15), RPS4X(4), VASP(2), WASF1(3), WASL(8)	16003679	300	66	292	84	89	121	33	10	45	2	0.12	0.26
274	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(10), CARS2(1), CDO1(4), CTH(5), GOT1(6), GOT2(5), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), SDS(3), SULT1B1(4), SULT1C2(7), SULT1C4(4), SULT4A1(3)	4208312	73	37	68	35	20	23	10	6	14	0	0.12	0.27
275	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(3), FDPS(7), HMGCR(15), IDI1(4), MVD(3), MVK(7), NQO1(3), NQO2(4), PMVK(2), SC5DL(3), SQLE(6), VKORC1(3)	3405750	64	32	62	27	13	24	9	7	11	0	0.12	0.27
276	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(11), NR3C1(13), PPARG(5), RETN(2), RXRA(1), TNF(1)	1975096	37	23	35	10	13	12	2	2	8	0	0.12	0.27
277	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(17), GNAS(25), GNB1(3), PPP2CA(6), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAG2(4), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5)	4941803	110	40	105	28	22	57	8	6	15	2	0.12	0.27
278	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(6), ALG1(2), ALG10(9), ALG10B(8), ALG11(6), ALG12(1), ALG13(17), ALG14(2), ALG2(2), ALG3(5), ALG6(5), ALG8(8), ALG9(6), B3GNT1(7), B3GNT2(4), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), B4GALT5(2), B4GALT7(4), C1GALT1(4), C1GALT1C1(5), CHPF(5), CHST1(10), CHST11(9), CHST12(5), CHST14(2), CHST2(5), CHST3(4), CHST4(6), CHST7(4), CHSY1(1), DAD1(1), DDOST(3), DPAGT1(4), EXT1(12), EXT2(8), EXTL1(13), EXTL2(10), EXTL3(10), FUT11(2), FUT8(13), GALNT1(8), GALNT10(5), GALNT11(14), GALNT12(2), GALNT13(19), GALNT14(11), GALNT2(8), GALNT3(10), GALNT4(8), GALNT5(7), GALNT6(2), GALNT7(11), GALNT8(13), GALNTL1(12), GALNTL2(13), GALNTL4(6), GALNTL5(10), GANAB(13), GCNT1(8), GCNT3(7), GCNT4(1), HS2ST1(5), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), HS3ST5(10), HS6ST2(11), HS6ST3(2), MAN1A1(11), MAN1A2(9), MAN1B1(4), MAN1C1(7), MAN2A1(23), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), MGAT5B(7), NDST1(13), NDST2(7), NDST3(17), NDST4(11), OGT(19), RPN1(6), RPN2(9), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4), ST6GAL1(10), ST6GALNAC1(4), STT3B(6), UST(4), WBSCR17(14), XYLT1(15), XYLT2(9)	37057667	729	96	698	227	186	299	114	33	91	6	0.12	0.28
279	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(4), BIRC3(3), CASP8(21), FADD(1), RIPK1(8), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF2(5)	2728663	52	27	51	12	9	17	9	3	14	0	0.13	0.28
280	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(28), ABCB11(18), ABCB4(29), ABCC1(23), ABCC3(14), GSTP1(2)	5203986	114	39	110	39	39	34	12	7	20	2	0.13	0.28
281	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(7), AGTR2(8), CALM2(3), CALM3(1), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CDK5(1), F2(9), FYN(7), GNA11(3), GNAI1(4), GNB1(3), GRB2(3), JAK2(21), MAP2K1(2), MAPK1(2), MAPK14(6), MAPK3(4), MAPK8(7), MAPT(11), MYLK(17), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(7), SHC1(11), SOS1(21), STAT1(14), STAT3(12), STAT5A(5), SYT1(4)	14175090	256	65	248	73	66	103	35	13	31	8	0.13	0.28
282	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(19), BIRC2(13), BIRC3(3), CASP10(10), CASP3(4), CASP7(4), CASP8(21), CASP9(3), DFFA(1), DFFB(3), GZMB(2), PRF1(8), SCAP(16), SREBF1(6), SREBF2(10)	5852632	123	43	118	33	34	42	16	7	24	0	0.13	0.28
283	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(9), ENO1(5), GPI(9), HK1(13), PGAM1(2), PGK1(6), PKLR(10), TPI1(1)	2575703	55	27	53	14	16	22	4	3	8	2	0.13	0.28
284	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(8), CNR2(3), DNMT1(15), MTNR1A(6), MTNR1B(4), PTAFR(6), PTGDR(6), PTGER2(5), PTGER4(8), PTGFR(10), PTGIR(3)	3471953	74	36	70	28	18	36	12	4	4	0	0.13	0.28
285	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), ESRRA(2), HDAC5(15), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), PPARA(2), PPP3CA(4), PPP3CB(7), PPP3CC(6), SLC2A4(4), SYT1(4), YWHAH(4)	6774216	122	42	120	37	28	52	16	4	22	0	0.13	0.28
286	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	90	ANK2(42), B3GALT4(6), CDR1(2), DGKI(21), FAU(1), IL6ST(10), MRPL19(6), PIGK(6), RPL10(5), RPL11(4), RPL12(1), RPL14(2), RPL15(1), RPL17(5), RPL18(4), RPL18A(4), RPL19(4), RPL21(2), RPL22(15), RPL23(1), RPL24(3), RPL27(1), RPL27A(1), RPL28(2), RPL29(3), RPL3(5), RPL30(2), RPL31(1), RPL35(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(5), RPL3L(3), RPL4(4), RPL5(6), RPL6(2), RPL7(2), RPL8(1), RPL9(1), RPLP0(6), RPS10(2), RPS12(3), RPS13(1), RPS14(1), RPS18(4), RPS20(3), RPS21(2), RPS24(4), RPS25(1), RPS27(2), RPS27A(3), RPS29(2), RPS3(2), RPS3A(2), RPS4X(4), RPS5(1), RPS6(6), RPS6KA1(5), RPS6KA2(16), RPS6KA3(17), RPS6KA6(15), RPS6KB1(3), RPS6KB2(6), RPS7(3), RPS8(5), RPS9(1), RPSA(1), SLC36A2(5), TBC1D10C(2), TSPAN9(4), UBB(3), UBC(5)	17897515	331	69	311	106	89	119	45	16	60	2	0.13	0.28
287	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(4), FUCA1(3), FUCA2(3), GLB1(9), HEXA(3), HEXB(4), LCT(30), MAN2B1(20), MAN2B2(9), MAN2C1(8), MANBA(14), NEU2(5), NEU3(3)	6820343	115	47	112	33	32	51	15	6	11	0	0.13	0.29
288	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD36(7), CD44(12), CD47(8), CHAD(3), COL11A1(36), COL11A2(13), COL1A1(12), COL1A2(22), COL2A1(14), COL3A1(18), COL4A1(23), COL4A2(11), COL4A4(24), COL4A6(35), COL5A1(33), COL5A2(24), COL5A3(23), COL6A3(54), COL6A6(38), DAG1(7), FN1(39), FNDC1(37), FNDC3A(9), FNDC4(4), FNDC5(1), GP1BA(11), GP5(5), GP6(3), HMMR(12), HSPG2(37), IBSP(6), ITGA1(20), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAV(10), ITGB1(12), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), LAMA1(39), LAMA2(62), LAMA3(35), LAMA4(22), LAMB1(22), LAMB2(27), LAMB3(16), LAMB4(27), LAMC1(17), LAMC2(12), LAMC3(13), RELN(48), SDC1(1), SDC2(2), SDC3(2), SDC4(8), SPP1(3), SV2A(17), SV2B(15), SV2C(16), THBS1(12), THBS2(22), THBS3(6), THBS4(9), TNC(19), TNN(16), TNR(16), TNXB(25), VWF(31)	74339038	1376	122	1347	404	357	568	178	69	171	33	0.13	0.29
289	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(53), ASAH1(9), CAMP(1), CASP3(4), CERK(8), CREB1(5), CREB3(2), CREB5(6), CXCL2(2), DAG1(7), EPHB2(10), FOS(6), ITPKB(6), JUN(1), MAP2K4(6), MAPK1(2), MAPK10(9), MAPK8(7), MAPK8IP1(5), MAPK9(7)	8413278	156	46	153	49	42	55	15	8	28	8	0.14	0.29
290	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(32), GNA12(10), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAR2A(4), PRKAR2B(5)	3482708	61	34	58	17	12	29	5	4	11	0	0.14	0.29
291	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12), C9(20), MASP1(14), MASP2(6), MBL2(3)	7443416	182	46	174	50	39	80	27	9	23	4	0.14	0.29
292	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(19), BID(3), BIRC2(13), BIRC3(3), CASP10(10), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CFLAR(7), CHUK(11), CYCS(3), DFFA(1), DFFB(3), FADD(1), GAS2(7), LMNA(8), MAP3K14(12), NFKB1(12), NFKBIA(3), RELA(6), RIPK1(8), SPTAN1(29), TNFRSF10A(3), TNFRSF10B(5), TNFRSF25(1), TNFSF10(1), TNFSF12(4), TRAF2(5)	11288209	214	57	210	55	53	82	28	10	41	0	0.14	0.30
293	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(17), ADRB2(8), GNAS(25), PLCE1(36), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5)	4771874	115	41	110	29	25	51	17	6	14	2	0.14	0.30
294	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(12), AGXT(5), AGXT2(9), ALAS1(12), ALAS2(11), AMT(5), AOC2(6), AOC3(14), ATP6V0C(2), BHMT(2), CBS(13), CHDH(5), CHKA(8), CTH(5), DAO(5), DLD(7), DMGDH(6), GARS(8), GATM(8), GLDC(20), MAOA(14), MAOB(7), PEMT(2), PISD(5), PLCB2(9), PLCG1(12), PLCG2(27), PSPH(1), SARDH(9), SARS(4), SHMT1(6), SHMT2(8), TARS(10)	14110560	277	61	268	77	75	111	37	15	37	2	0.14	0.30
295	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(5), HK1(13), HK2(8), HK3(12), IMPA1(4), IMPA2(6), PGM1(9), PGM3(6), TGDS(3)	3699003	66	32	64	25	20	24	9	5	8	0	0.15	0.31
296	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(9), ELK1(2), EPO(2), EPOR(4), FOS(6), GRB2(3), JAK2(21), JUN(1), MAP2K1(2), MAPK3(4), MAPK8(7), PLCG1(12), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5)	7451064	122	44	116	24	34	42	15	9	14	8	0.15	0.31
297	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(22), CAPN1(4), CAPNS1(3), CAPNS2(6), CDK5(1), CDK5R1(5), CSNK1A1(5), GSK3B(11), MAPT(11), PPP2CA(6)	3096006	74	31	72	18	14	34	8	3	15	0	0.15	0.31
298	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(5), APEX1(3), CREBBP(37), DFFA(1), DFFB(3), GZMA(6), GZMB(2), HMGB2(3), PRF1(8), SET(6)	3605076	74	33	72	23	18	29	7	5	15	0	0.15	0.31
299	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(13), CADM1(5), CADM3(6), CD2(4), CD22(13), CD226(5), CD274(3), CD276(2), CD28(6), CD34(4), CD4(8), CD40(4), CD40LG(7), CD58(1), CD6(8), CD80(7), CD86(6), CD8A(3), CD8B(1), CD99(2), CDH1(15), CDH2(14), CDH3(8), CDH4(19), CDH5(9), CLDN1(2), CLDN10(9), CLDN11(1), CLDN15(4), CLDN16(6), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(4), CLDN20(4), CLDN22(3), CLDN6(1), CLDN7(1), CLDN8(5), CLDN9(2), CNTN1(17), CNTN2(7), CNTNAP1(13), CNTNAP2(33), CTLA4(2), ESAM(1), F11R(2), GLG1(4), HLA-A(5), HLA-B(3), HLA-DMA(4), HLA-DMB(2), HLA-DOA(3), HLA-DOB(4), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(2), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(3), HLA-G(3), ICAM1(3), ICAM2(5), ICAM3(5), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(12), ITGA8(16), ITGA9(15), ITGAL(13), ITGAM(24), ITGAV(10), ITGB1(12), ITGB2(14), ITGB7(8), ITGB8(5), JAM2(9), JAM3(3), L1CAM(16), MAG(10), MPZ(3), MPZL1(2), NCAM1(13), NCAM2(35), NEGR1(3), NEO1(16), NFASC(33), NLGN1(12), NLGN2(3), NLGN3(21), NRCAM(14), NRXN1(39), NRXN2(22), NRXN3(24), OCLN(5), PTPRC(15), PTPRF(34), PTPRM(19), PVR(2), PVRL1(9), PVRL2(5), PVRL3(9), SDC1(1), SDC2(2), SDC3(2), SDC4(8), SELE(10), SELL(4), SELP(15), SELPLG(11), SIGLEC1(10), SPN(4), VCAM1(9), VCAN(59)	50075041	1009	113	979	310	283	413	135	48	113	17	0.15	0.31
300	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(9), BCAT2(6), COASY(11), DPYD(16), DPYS(3), ENPP1(11), ENPP3(16), ILVBL(7), PANK1(3), PANK2(8), PANK3(7), PANK4(8), PPCDC(1), PPCS(4), UPB1(9), VNN1(7)	5766114	126	42	124	32	32	48	20	6	20	0	0.16	0.32
301	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(8), CYP11A1(10), CYP11B1(6), CYP11B2(7), CYP17A1(3), CYP21A2(7), HSD11B1(4), HSD3B1(1), HSD3B2(5)	3168901	56	29	55	21	8	30	7	3	8	0	0.16	0.32
302	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(8), CYP11A1(10), CYP11B1(6), CYP11B2(7), CYP17A1(3), CYP21A2(7), HSD11B1(4), HSD3B1(1), HSD3B2(5)	3168901	56	29	55	21	8	30	7	3	8	0	0.16	0.32
303	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(6), CD4(8), HLA-DRB1(1)	866136	15	11	15	5	2	9	0	0	4	0	0.16	0.32
304	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(6), C1QB(3), C1R(15), C1S(9), C2(6), C3(24), C5(20), C6(23), C7(21), C8A(12), C8B(4), C9(20), MASP1(14)	7357376	177	45	168	46	36	78	27	9	23	4	0.16	0.32
305	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(24), EGFR(20), ERBB3(16), NRG1(25)	3597189	85	35	82	17	23	36	13	6	7	0	0.16	0.32
306	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(6), CD3D(3), CD3E(2), CD3G(2), IFNG(5), IL2(4), IL2RA(3), TGFB1(4), TGFB2(6), TGFB3(9), TGFBR1(8), TGFBR2(6), TGFBR3(8), TOB1(2), TOB2(6)	3716928	74	33	74	25	16	33	11	6	8	0	0.16	0.32
307	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(17), CAP1(7), CCNB1(8), CDC25C(8), GNAI1(4), GNAS(25), GNB1(3), MAPK1(2), MAPK3(4), PIN1(1), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), RPS6KA1(5), SRC(2)	6510121	119	45	113	28	24	54	13	5	21	2	0.16	0.32
308	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(30), APOC1(1), APOE(1), CETP(6), CYP7A1(12), HMGCR(15), LCAT(2), LDLR(12), LIPC(8), LPL(11), LRP1(53), SCARB1(8), SOAT1(10)	8783728	169	54	166	43	53	67	26	8	15	0	0.16	0.33
309	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(8), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6)	3392127	52	31	52	22	10	23	7	3	9	0	0.16	0.33
310	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	55	ATP12A(17), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ATP7B(13), COX10(5), COX4I1(2), COX5A(1), COX5B(1), COX6A1(2), COX6B1(4), COX6C(2), COX7A1(4), COX7A2(2), COX7B(2), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(8), NDUFA4(2), NDUFA5(7), NDUFA8(6), NDUFB5(2), NDUFB6(1), NDUFS1(13), NDUFS2(5), NDUFV1(4), NDUFV2(3), PPA2(5), SDHA(12), SDHB(1), SHMT1(6), UQCRB(3), UQCRC1(6), UQCRH(1)	12060418	243	63	239	69	70	101	28	9	35	0	0.16	0.33
311	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ABP1(12), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), AOX1(19), DBH(12), DCT(15), DDC(11), FAH(7), GOT1(6), GOT2(5), GSTZ1(4), HPD(7), MAOA(14), MAOB(7), PNMT(3), TAT(9), TPO(18), TYR(10)	10362323	240	53	232	56	63	96	38	13	30	0	0.17	0.33
312	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(14), COPS5(6), CREB1(5), EDN1(2), EP300(29), EPO(2), HIF1A(17), JUN(1), LDHA(6), NOS3(11), P4HB(1), VHL(2)	5601682	103	37	102	17	27	33	20	4	19	0	0.17	0.33
313	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(3), ADCY1(17), ADCY2(17), ADCY3(8), ADCY4(8), ADCY5(11), ADCY6(16), ADCY7(6), ADCY8(16), ADCY9(25), ADK(1), ADSL(7), ADSS(8), ADSSL1(6), AK1(2), AK2(4), AK5(6), AK7(15), ALLC(10), AMPD1(21), AMPD2(9), AMPD3(4), ATIC(9), CANT1(5), DCK(4), DGUOK(3), ENPP1(11), ENPP3(16), ENTPD1(6), ENTPD3(8), ENTPD4(4), ENTPD5(2), ENTPD6(15), FHIT(2), GART(8), GDA(5), GMPR(7), GMPR2(4), GMPS(13), GUCY1A2(10), GUCY1A3(12), GUCY1B3(7), GUCY2C(12), GUCY2D(7), GUCY2F(25), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(10), ITPA(1), NME6(2), NME7(4), NPR1(14), NPR2(16), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT2(3), NUDT5(1), NUDT9(1), PAICS(4), PAPSS1(6), PAPSS2(6), PDE10A(14), PDE11A(12), PDE1A(12), PDE1C(14), PDE2A(14), PDE3B(15), PDE4A(12), PDE4B(17), PDE4C(6), PDE4D(7), PDE5A(14), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(7), PDE8B(20), PDE9A(10), PFAS(10), PKLR(10), PKM2(5), PNPT1(9), POLA1(26), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), PPAT(10), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(5), PRPS2(10), PRUNE(4), RFC5(7), RRM1(4), RRM2(5), RRM2B(5), XDH(10), ZNRD1(1)	55894213	1005	106	983	294	269	415	137	59	121	4	0.17	0.33
314	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(26), POLB(4), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLG(7), POLG2(8), POLH(13), POLI(13), POLK(12), POLL(8), POLM(12), POLQ(23), PRIM1(2), PRIM2(7), REV1(13), REV3L(40), RFC5(7)	14673883	230	65	220	55	61	84	35	11	37	2	0.18	0.35
315	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(8), GALNT10(5), GALNT2(8), GALNT3(10), GALNT4(8), GALNT6(2), GALNT7(11), GALNT8(13), GCNT1(8), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), WBSCR17(14)	4989603	97	40	95	30	24	38	20	7	8	0	0.18	0.36
316	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), FDXR(6), SHMT1(6)	5607418	109	41	108	33	24	51	12	4	18	0	0.19	0.36
317	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(12), EXT2(8), EXTL1(13), EXTL2(10), EXTL3(10), GLCE(5), HS2ST1(5), HS3ST1(5), HS3ST2(4), HS3ST3A1(3), HS3ST5(10), HS6ST2(11), HS6ST3(2), NDST1(13), NDST2(7), NDST3(17), NDST4(11)	6906144	146	47	143	48	36	60	21	8	19	2	0.19	0.36
318	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(5), ICAM1(3), ITGAL(13), ITGB2(14), PRF1(8)	2865849	54	30	52	22	13	30	6	0	5	0	0.19	0.36
319	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(9), ALDH4A1(2), ALDH5A1(9), CAD(38), CPS1(24), EPRS(11), GAD1(8), GAD2(12), GCLC(8), GCLM(3), GFPT1(11), GLS(10), GLS2(9), GLUD1(4), GLUL(6), GMPS(13), GOT1(6), GOT2(5), GPT2(7), GSS(5), NADSYN1(12), PPAT(10), QARS(6)	11208144	228	58	221	60	48	99	36	10	31	4	0.19	0.36
320	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(9), CAMK1G(5), HDAC9(19), MEF2A(5), MEF2B(3), MEF2C(11), MEF2D(7), MYOD1(3), YWHAH(4)	2814942	66	28	62	15	15	27	7	3	14	0	0.19	0.37
321	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	5321096	103	40	102	33	24	48	10	4	17	0	0.19	0.37
322	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	5321096	103	40	102	33	24	48	10	4	17	0	0.19	0.37
323	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	5321096	103	40	102	33	24	48	10	4	17	0	0.19	0.37
324	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(5), HK1(13), HK2(8), HK3(12), IMPA1(4), PGM1(9), PGM3(6), TGDS(3)	3521187	60	30	58	25	20	19	9	5	7	0	0.20	0.37
325	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(11), FOS(6), GRB2(3), IL3RA(11), JAK2(21), MAP2K1(2), MAPK3(4), RAF1(7), SHC1(11), SOS1(21), STAT5A(5), STAT5B(5)	5983843	107	39	104	24	28	45	13	8	5	8	0.20	0.38
326	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	B3GALNT1(5), B3GALT1(10), B3GALT2(8), B3GALT4(6), B3GALT5(6), B3GNT1(7), B3GNT2(4), B3GNT3(2), B3GNT4(5), B3GNT5(6), B4GALNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), B4GALT6(5), FUT1(5), FUT2(3), FUT3(9), FUT6(13), FUT9(12), GBGT1(6), GCNT2(17), PIGA(8), PIGB(10), PIGC(4), PIGF(4), PIGG(12), PIGH(3), PIGK(6), PIGL(1), PIGN(9), PIGO(15), PIGP(2), PIGS(3), PIGT(10), PIGU(3), PIGV(6), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4), ST3GAL5(2), ST3GAL6(8), ST6GALNAC3(10), ST6GALNAC4(5), ST6GALNAC5(5), ST6GALNAC6(8), ST8SIA1(4), ST8SIA5(8), UGCG(5)	15546233	327	66	316	73	89	147	37	19	35	0	0.20	0.38
327	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(2), ACP5(4), ACP6(3), ACPP(5), ACPT(7), ENPP1(11), ENPP3(16), FLAD1(8), LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), PHPT1(2), RFK(2), TYR(10)	5220238	104	38	102	34	23	38	22	7	14	0	0.20	0.38
328	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(6), CD4(8), CD80(7), HLA-DRB1(1), IL10(4), IL2(4)	1439736	30	17	30	11	5	15	5	0	5	0	0.20	0.38
329	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAD(3), ALAS1(12), ALAS2(11), CPO(4), FECH(5), GATA1(9), HBB(3), HMBS(7), UROD(2), UROS(3)	2819483	59	27	57	12	10	29	6	3	11	0	0.20	0.38
330	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(30), ABCA10(27), ABCA12(50), ABCA13(82), ABCA3(19), ABCA4(26), ABCA5(27), ABCA6(24), ABCA8(29), ABCA9(29), ABCB1(28), ABCB10(12), ABCB11(18), ABCB4(29), ABCB5(26), ABCB6(13), ABCB7(16), ABCB8(6), ABCB9(11), ABCC1(23), ABCC10(14), ABCC11(23), ABCC12(24), ABCC2(30), ABCC3(14), ABCC4(12), ABCC5(20), ABCC6(16), ABCC8(19), ABCC9(34), ABCD1(14), ABCD2(8), ABCD3(9), ABCD4(3), ABCG1(9), ABCG2(8), ABCG4(10), ABCG5(3), ABCG8(9), CFTR(13), TAP1(7), TAP2(2)	39201258	826	101	796	202	216	325	105	49	111	20	0.21	0.38
331	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(4), IL5(2), MAF(2), MAP2K3(8), MAPK14(6), NFATC2(15), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5)	3513778	66	32	64	23	11	32	4	6	11	2	0.21	0.38
332	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(17), ADRB2(8), CFTR(13), GNAS(25), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), SLC9A3R1(3)	4170072	95	36	90	23	21	44	9	5	14	2	0.21	0.39
333	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(20), BMPR1A(8), BMPR1B(6), BMPR2(14)	2144786	48	26	47	8	14	18	9	2	5	0	0.21	0.39
334	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(6), CD3D(3), CD3E(2), CD3G(2), CD8A(3), ICAM1(3), ITGAL(13), ITGB2(14), PTPRC(15), THY1(1)	3648096	66	32	65	27	16	33	7	2	8	0	0.21	0.39
335	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(9), ADC(8), ALDH4A1(2), ALDH5A1(9), CAD(38), CPS1(24), EARS2(4), EPRS(11), GAD1(8), GAD2(12), GCLC(8), GCLM(3), GFPT1(11), GFPT2(12), GLS(10), GLS2(9), GLUD1(4), GLUD2(9), GLUL(6), GMPS(13), GNPNAT1(2), GOT1(6), GOT2(5), GPT2(7), GSR(5), GSS(5), NADSYN1(12), NAGK(3), PPAT(10), QARS(6)	13372528	271	62	264	78	60	122	39	10	36	4	0.22	0.40
336	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(25), FYN(7), ITGA1(20), ITGB1(12), L1CAM(16), LYN(7), RAP1B(2), SELP(15)	5669558	125	41	120	38	33	58	12	4	18	0	0.22	0.40
337	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNB1(3), HTR2C(18), PLCB1(6), TUB(12)	2477713	45	27	43	11	15	15	8	3	4	0	0.22	0.41
338	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(9), COASY(11), DPYD(16), DPYS(3), ENPP1(11), ENPP3(16), PANK1(3), PANK2(8), PANK3(7), PANK4(8), PPCS(4), UPB1(9)	4559642	105	36	104	23	27	36	17	5	20	0	0.22	0.41
339	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	CAD(38), CANT1(5), CDA(1), CTPS(10), CTPS2(10), DCK(4), DCTD(5), DHODH(3), DPYD(16), DPYS(3), DUT(1), ENTPD1(6), ITPA(1), NT5C(1), NT5E(6), NT5M(4), NUDT2(3), POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), RRM1(4), RRM2(5), TK1(2), TK2(7), TXNRD1(10), TYMS(1), UCK1(5), UCK2(6), UMPS(7), UNG(1), UPB1(9), UPP1(4)	19174731	319	71	312	92	64	138	43	23	51	0	0.22	0.41
340	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(5), TAT(9)	900313	20	14	19	3	5	7	3	3	2	0	0.23	0.41
341	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), AGPS(10), ENPP2(20), ENPP6(9), PAFAH1B1(1), PAFAH1B2(3), PAFAH2(6), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLD1(16), PLD2(7), PPAP2A(4), PPAP2B(3)	7669749	138	46	135	42	33	56	17	7	23	2	0.23	0.41
342	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CSF1(5), IL6(2), LDLR(12), LPL(11)	1875911	36	22	35	9	13	14	3	1	5	0	0.23	0.41
343	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(7), ACADM(6), ACADS(5), ACADVL(6), ACSL1(13), ACSL3(10), ACSL4(24), CPT1A(10), CPT2(7), EHHADH(9), HADHA(7), PECR(5), SCP2(13), SLC25A20(5)	5836619	127	39	122	33	33	49	24	8	13	0	0.23	0.42
344	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(12), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), DDC(11), EPX(14), ESCO1(11), ESCO2(6), GOT1(6), GOT2(5), HPD(7), LPO(6), MAOA(14), MAOB(7), MPO(9), NAT6(2), PNPLA3(6), PRDX6(2), SH3GLB1(8), TAT(9), TPO(18)	11884275	192	55	187	61	56	73	28	8	27	0	0.24	0.43
345	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(10), DARS(4), EPRS(11), FARS2(2), GARS(8), HARS(4), IARS(13), KARS(7), LARS(23), LARS2(9), MARS(12), MARS2(7), NARS(7), QARS(6), RARS(11), SARS(4), TARS(10), WARS(6), WARS2(5), YARS(8)	11301115	177	52	176	68	39	80	32	7	19	0	0.24	0.43
346	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(13), ACO2(8), CS(5), DLD(7), DLST(10), FH(11), IDH1(4), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), PC(8), PCK1(15), SDHA(12), SDHB(1), SUCLA2(5), SUCLG1(1), SUCLG2(14)	7193183	147	46	143	56	44	62	20	9	12	0	0.24	0.43
347	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(7), B3GNT2(4), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), CHST1(10), CHST2(5), CHST4(6), FUT8(13), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4)	3844793	82	35	76	32	20	38	11	3	10	0	0.25	0.45
348	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(19), ARHGDIB(2), BIRC2(13), BIRC3(3), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CYCS(3), DFFA(1), DFFB(3), GZMB(2), LMNA(8), LMNB1(5), PRF1(8)	6439855	137	41	131	37	38	48	20	4	27	0	0.26	0.45
349	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(2), ACP5(4), ACP6(3), ACPP(5), ACPT(7), ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), CMBL(4), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), PON1(12), PON2(8), PON3(1)	6073229	122	41	119	36	33	42	25	8	14	0	0.26	0.46
350	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(27), ACACB(31), MCAT(3), OLAH(7), OXSM(6)	4227432	74	35	71	25	20	27	11	2	10	4	0.26	0.46
351	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(24), ARHGEF1(11), GNA12(10), GNA13(9), GNB1(3), MYL2(1), MYLK(17), PLCB1(6), PPP1R12B(18), PRKCA(10), ROCK1(27)	7293563	136	43	132	32	39	46	17	7	19	8	0.27	0.47
352	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(8), AKT3(8), CAPN1(4), CAPN10(8), CAPN11(8), CAPN2(6), CAPN3(13), CAPN5(6), CAPN6(6), CAPN7(8), CAPN9(12), CAPNS1(3), CAV2(1), CDC42(5), CRK(1), CSK(1), DOCK1(32), FYN(7), GIT2(9), GRB2(3), ILK(8), ITGA10(11), ITGA11(12), ITGA2(21), ITGA2B(11), ITGA3(6), ITGA4(12), ITGA5(12), ITGA6(12), ITGA7(10), ITGA8(16), ITGA9(15), ITGAD(11), ITGAE(14), ITGAL(13), ITGAM(24), ITGAV(10), ITGAX(9), ITGB1(12), ITGB2(14), ITGB3(16), ITGB4(12), ITGB5(8), ITGB6(6), ITGB7(8), ITGB8(5), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAPK10(9), MAPK4(6), MAPK6(11), MAPK7(17), MYLK2(7), PAK1(3), PAK2(6), PAK3(14), PAK4(2), PAK6(3), PDPK1(3), PIK3R2(4), PTK2(11), PXN(6), RAC2(2), RAP1B(2), RAPGEF1(18), RHO(8), ROCK1(27), ROCK2(15), SDCCAG8(14), SEPP1(4), SHC1(11), SHC3(9), SORBS1(22), SOS1(21), SRC(2), TLN1(28), TNS1(20), VASP(2), VAV2(5), VAV3(13), VCL(14), ZYX(12)	45473574	827	99	800	281	225	335	101	37	117	12	0.27	0.47
353	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(3), SLPI(3)	610167	10	10	9	1	3	3	2	0	2	0	0.27	0.47
354	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(2), ACADM(6), ACADS(5), ACAT1(6), ACAT2(5), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH7A1(2), ALDH9A1(4), AOX1(19), AUH(4), BCAT1(9), BCAT2(6), BCKDHA(7), BCKDHB(3), DBT(3), DLD(7), ECHS1(3), EHHADH(9), HADH(1), HADHA(7), HADHB(5), HIBADH(4), HIBCH(7), HMGCL(3), HMGCS1(4), HMGCS2(8), HSD17B10(4), HSD17B4(10), IVD(4), MCCC1(11), MCCC2(7), MUT(7), OXCT1(10), OXCT2(2), PCCA(10), PCCB(8)	14626083	248	59	245	60	61	108	42	15	20	2	0.27	0.47
355	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(9), CDC25B(3), CDC25C(8), CSK(1), GRB2(3), PRKCA(10), PTPRA(11), SRC(2)	3211443	55	30	52	23	12	18	11	4	10	0	0.27	0.47
356	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(10), AARS2(13), CARS(10), CARS2(1), DARS(4), DARS2(7), EARS2(4), EPRS(11), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(4), HARS2(8), IARS(13), IARS2(21), KARS(7), LARS(23), LARS2(9), MARS(12), MARS2(7), MTFMT(1), NARS(7), NARS2(7), PARS2(4), QARS(6), RARS(11), RARS2(7), SARS(4), SARS2(7), TARS(10), TARS2(10), VARS(8), VARS2(5), WARS(6), WARS2(5), YARS(8), YARS2(3)	19103987	296	71	293	99	82	120	50	12	32	0	0.28	0.48
357	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(7), F13A1(10), F2(9), F2R(8), FGA(30), FGB(6), FGG(12), PLAT(6), PLAU(5), PLG(13), SERPINB2(9), SERPINE1(5)	4749169	120	40	115	23	42	42	21	7	8	0	0.28	0.48
358	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(6), G6PC2(9), GAA(5), GALE(2), GALK1(3), GALK2(3), GALT(2), GANC(17), GCK(5), GLA(3), GLB1(9), HK1(13), HK2(8), HK3(12), HSD3B7(3), LALBA(1), LCT(30), MGAM(49), PFKM(7), PFKP(11), PGM1(9), PGM3(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), UGP2(8)	12427761	251	61	244	77	75	110	28	17	21	0	0.28	0.48
359	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(18), AMY2A(7), AMY2B(11), ASCC3(25), ATP13A2(6), DDX18(14), DDX19A(1), DDX23(12), DDX4(18), DDX41(2), DDX47(8), DDX50(11), DDX52(7), DDX54(8), DDX55(5), DDX56(6), DHX58(5), ENPP1(11), ENPP3(16), ENTPD7(7), ERCC2(4), ERCC3(11), G6PC(6), G6PC2(9), GAA(5), GANC(17), GBA(4), GBA3(9), GBE1(12), GCK(5), GPI(9), GUSB(5), GYS1(12), GYS2(19), HK1(13), HK2(8), HK3(12), IFIH1(5), LYZL1(2), MGAM(49), NUDT5(1), NUDT8(1), PGM1(9), PGM3(6), PYGB(10), PYGL(9), PYGM(10), RAD54B(14), RAD54L(5), RUVBL2(6), SETX(41), SI(47), SKIV2L2(20), SMARCA2(24), SMARCA5(19), TREH(4), UGDH(3), UGP2(8), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), UXS1(5)	42214570	804	91	776	203	212	294	139	48	104	7	0.28	0.49
360	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(2), ACADL(7), ACADM(6), ACADS(5), ACADSB(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH9A1(4), AOX1(19), BCAT1(9), BCKDHA(7), BCKDHB(3), ECHS1(3), EHHADH(9), HADHA(7), HADHB(5), HIBADH(4), HMGCL(3), IVD(4), MCCC1(11), MCCC2(7), MUT(7), OXCT1(10), PCCA(10), PCCB(8), SDS(3)	12155301	210	55	208	61	52	88	33	16	19	2	0.29	0.49
361	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(4), FUCA1(3), FUCA2(3), GLB1(9), HEXA(3), HEXB(4), LCT(30), MAN2C1(8), MANBA(14), NEU2(5), NEU3(3)	5536196	86	39	85	28	27	30	14	5	10	0	0.29	0.49
362	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(5), MMP2(11), MMP9(14), RECK(16), TIMP1(5), TIMP2(3), TIMP3(8), TIMP4(1)	2612748	63	28	61	22	21	27	8	1	6	0	0.29	0.50
363	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(8)	652231	14	12	13	7	5	5	1	0	3	0	0.29	0.50
364	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(6), TAX1BP3(1), UBE2A(4), UBE2B(3), UBE2C(1), UBE2D2(3), UBE2D3(3), UBE2E1(3), UBE2E3(8), UBE2G1(2), UBE2H(3), UBE2J1(5), UBE2L3(4), UBE2L6(1), UBE2M(1), UBE2N(4), UBE3A(13)	3369183	65	31	65	23	12	26	14	1	12	0	0.29	0.50
365	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(7), IL22RA1(2), IL22RA2(1), JAK1(31), JAK2(21), JAK3(9), STAT1(14), STAT3(12), STAT5A(5), STAT5B(5), TYK2(7)	6305298	114	39	105	39	19	46	13	7	17	12	0.30	0.50
366	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GBA3(9), GGT1(10), SHMT1(6), SHMT2(8)	1487297	35	20	32	7	12	11	4	0	6	2	0.30	0.50
367	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(6), FOSL1(4), FOSL2(7), IFNAR1(9), IFNAR2(8), IFNB1(4), MAPK8(7), NFKB1(12), RELA(6), TNFRSF11A(6), TNFSF11(6), TRAF6(4)	3892354	79	33	75	16	20	28	18	4	9	0	0.31	0.52
368	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(12), ALAS2(11), CPOX(8), FECH(5), HMBS(7), UROD(2), UROS(3)	2723883	51	24	49	9	9	25	6	3	8	0	0.31	0.52
369	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(23), ABCC2(30), ABCG2(8), BCHE(18), CES1(12), CES2(3), CYP3A4(14), CYP3A5(7), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4)	8174517	166	45	160	44	37	71	25	13	18	2	0.31	0.52
370	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(8), ARSD(9), ARSE(7), CARM1(6), CYP11B1(6), CYP11B2(7), CYP19A1(12), HEMK1(2), HSD11B1(4), HSD17B1(3), HSD17B12(4), HSD17B2(3), HSD17B3(6), HSD17B7(4), HSD17B8(2), HSD3B1(1), HSD3B2(5), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SRD5A1(4), SRD5A2(4), STS(9), SULT1E1(13), SULT2A1(7), SULT2B1(4), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), WBSCR22(9)	16832770	354	61	340	92	96	136	50	23	43	6	0.31	0.52
371	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(10), F2(9), F2R(8), F3(6), F5(46), F7(2), FGA(30), FGB(6), FGG(12), PROC(7), SERPINC1(9), TFPI(11)	5539542	156	41	150	31	53	59	22	10	12	0	0.32	0.52
372	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(10), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD3B1(1), HSD3B2(5)	2460027	35	24	34	16	7	16	5	1	6	0	0.32	0.52
373	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), P4HB(1), SLC23A1(11), SLC23A2(5), SLC2A1(6), SLC2A3(14)	8897731	181	50	173	55	49	73	17	10	24	8	0.32	0.53
374	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(13), ACO2(8), AFMID(6), CS(5), GRHPR(4), HAO1(2), HAO2(7), HYI(2), MDH1(2), MDH2(5), MTHFD1(6), MTHFD1L(12), MTHFD2(3)	4704715	75	36	73	29	27	27	9	5	7	0	0.32	0.53
375	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(29), NRG2(6), NRG3(15), PRKCA(10), PSEN1(4)	3085490	75	28	74	22	15	28	14	9	9	0	0.32	0.53
376	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	107	ATP12A(17), ATP4A(13), ATP4B(2), ATP5A1(11), ATP5B(4), ATP5C1(1), ATP5E(1), ATP5F1(5), ATP5G1(4), ATP5G2(1), ATP5I(1), ATP5J(4), ATP5L(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), COX10(5), COX15(4), COX4I1(2), COX4I2(2), COX5A(1), COX5B(1), COX6A1(2), COX6B1(4), COX6C(2), COX7A1(4), COX7A2(2), COX7B(2), COX7B2(2), COX7C(2), COX8A(1), COX8C(2), CYC1(2), LHPP(2), NDUFA1(1), NDUFA10(8), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(2), NDUFA4L2(1), NDUFA5(7), NDUFA6(3), NDUFA8(6), NDUFA9(4), NDUFAB1(2), NDUFB1(1), NDUFB5(2), NDUFB6(1), NDUFB8(1), NDUFC1(1), NDUFC2(2), NDUFS1(13), NDUFS2(5), NDUFS4(2), NDUFS5(1), NDUFS8(3), NDUFV1(4), NDUFV2(3), NDUFV3(2), PPA1(5), PPA2(5), SDHA(12), SDHB(1), SDHC(6), SDHD(1), TCIRG1(8), UQCRB(3), UQCRC1(6), UQCRC2(4), UQCRH(1), UQCRQ(2)	18836546	365	72	361	98	99	156	39	19	52	0	0.32	0.53
377	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(9), BCMO1(4), RDH5(6)	1363973	25	18	25	16	8	9	1	1	6	0	0.33	0.53
378	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(5), GCK(5), GFPT1(11), GNE(8), GNPDA1(3), GNPDA2(5), HEXA(3), HEXB(4), HK1(13), HK2(8), HK3(12), PGM3(6), RENBP(6), UAP1(8)	5825386	103	40	100	37	25	40	17	10	11	0	0.33	0.53
379	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(5), BDH1(6), BDH2(6), HMGCL(3), HMGCS1(4), HMGCS2(8), OXCT1(10), OXCT2(2)	2438278	50	28	49	7	17	22	3	2	4	2	0.33	0.54
380	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(6), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(3), ST6GALNAC4(5), ST8SIA1(4)	1830979	30	21	30	11	13	10	5	0	2	0	0.33	0.54
381	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(19), BAK1(4), BAX(4), BCL2L1(3), BID(3), BIK(1), BIRC2(13), BIRC3(3), CASP3(4), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CYCS(3), DFFA(1), DFFB(3), DIABLO(2)	4604335	95	33	92	26	20	31	18	4	22	0	0.33	0.54
382	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(1), EPO(2), EPOR(4), GRIN1(5), HIF1A(17), JAK2(21), NFKB1(12), NFKBIA(3), RELA(6), SOD2(3)	4247030	81	30	80	20	15	27	17	5	11	6	0.34	0.54
383	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(3), CDC25A(9), CDC25B(3), CDC25C(8), CDK7(6), MNAT1(2), SHH(7), XPO1(15)	3028608	61	28	58	13	16	22	11	3	9	0	0.34	0.55
384	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(19), BAD(2), BAX(4), BCL2A1(2), BCL2L1(3), BCL2L2(2), CASP1(7), CASP10(10), CASP2(9), CASP3(4), CASP4(8), CASP6(4), CASP7(4), CASP8(21), CASP9(3), CD40(4), CD40LG(7), CRADD(3), CYCS(3), DAXX(11), DFFA(1), DFFB(3), FADD(1), FAS(7), FASLG(6), IKBKE(3), LTA(3), MCL1(1), NFKB1(12), NFKBIA(3), NGFR(4), NR3C1(13), NTRK1(11), PTPN13(27), RIPK1(8), TFG(5), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TRAF1(5), TRAF2(5), TRAF3(6), TRAF6(4)	15088548	268	60	263	73	70	99	42	13	42	2	0.34	0.55
385	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(5), HMGCL(3), OXCT1(10)	1166798	24	18	24	1	6	12	2	0	2	2	0.35	0.55
386	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(2), ACADL(7), ACADM(6), ACADS(5), ACADSB(4), ACADVL(6), ACAT1(6), ACAT2(5), ACOX1(4), ACOX3(8), ACSL1(13), ACSL3(10), ACSL4(24), ACSL5(18), ACSL6(13), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CPT1A(10), CPT1C(15), CPT2(7), CYP4A11(5), CYP4A22(8), ECHS1(3), EHHADH(9), GCDH(5), HADH(1), HADHA(7), HADHB(5), HSD17B10(4), HSD17B4(10)	16802656	293	57	286	73	74	127	44	15	31	2	0.35	0.56
387	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(4), CD3D(3), CD3E(2), CD3G(2), CD4(8), CXCR3(5), IFNG(5), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), JAK2(21), STAT4(9), TYK2(7)	4986735	103	36	100	26	19	44	12	8	14	6	0.36	0.57
388	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), F10(10), F11(10), F12(3), F2(9), F2R(8), F5(46), F8(41), F9(11), FGA(30), FGB(6), FGG(12), KLKB1(13), PROC(7), SERPINC1(9), SERPING1(7)	15568221	366	64	351	82	105	142	48	23	40	8	0.36	0.57
389	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(12), ICAM1(3), ITGAL(13), ITGAM(24), ITGB2(14), SELE(10), SELL(4)	4144977	80	34	78	24	19	33	12	4	10	2	0.36	0.58
390	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(9), CDC25B(3), CDK7(6), CDKN1A(1), CHEK1(4), NEK1(20), WEE1(1)	2580483	44	26	41	12	13	15	5	3	8	0	0.37	0.58
391	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ABP1(12), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), AOC2(6), AOC3(14), AOX1(19), CARM1(6), DBH(12), DCT(15), DDC(11), ECH1(6), ESCO1(11), ESCO2(6), FAH(7), GOT1(6), GOT2(5), GSTZ1(4), HEMK1(2), HPD(7), LCMT1(4), LCMT2(13), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), NAT6(2), PNMT(3), PNPLA3(6), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SH3GLB1(8), TAT(9), TPO(18), TYR(10), TYRP1(6), WBSCR22(9)	19924235	367	64	357	92	94	149	55	19	46	4	0.37	0.58
392	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(13), ACO2(8), FH(11), IDH1(4), IDH2(7), MDH1(2), MDH2(5), SDHB(1), SUCLA2(5)	3132573	56	30	55	30	18	24	4	5	5	0	0.37	0.58
393	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(27), ACACB(31), ACADM(6), ACAT1(6), ACAT2(5), ACSS1(4), ACSS2(11), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH7A1(2), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), HIBCH(7), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), MLYCD(5), MUT(7), PCCA(10), PCCB(8), SUCLA2(5), SUCLG1(1), SUCLG2(14)	13781457	224	55	218	53	62	86	34	15	23	4	0.37	0.58
394	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(5), G6PC(6), GAA(5), GALE(2), GALK1(3), GALK2(3), GALT(2), GANAB(13), GCK(5), GLA(3), GLB1(9), HK1(13), HK2(8), HK3(12), LALBA(1), LCT(30), MGAM(49), PFKM(7), PFKP(11), PGM1(9), PGM3(6)	10815706	206	55	200	71	62	91	23	12	18	0	0.37	0.58
395	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(9), ACADS(5), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH5A1(9), ALDH9A1(4), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), HMGCL(3), L2HGDH(3), OXCT1(10), PDHA1(4), PDHA2(10), PDHB(7), SDHB(1), SDS(3)	8755048	159	47	154	44	39	68	22	11	17	2	0.38	0.59
396	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(6), PLCG1(12), PRKCA(10), PTK2B(16)	2362515	44	25	42	24	12	17	6	5	4	0	0.38	0.59
397	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(5), IL8(3), NFKB1(12), NOX1(11), RELA(6), SOD1(2), TNF(1), XDH(10)	3572811	55	28	54	18	16	17	10	3	9	0	0.38	0.59
398	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(13), ACTN2(9), ACTN3(10), BCR(6), CAPN1(4), CAPNS1(3), CAPNS2(6), CRKL(5), CSK(1), FYN(7), GRB2(3), ITGA1(20), ITGB1(12), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(4), MAPK8(7), PPP1R12B(18), PTK2(11), PXN(6), RAF1(7), RAP1A(3), ROCK1(27), SHC1(11), SOS1(21), SRC(2), TLN1(28), VCL(14), ZYX(12)	15465451	279	64	270	75	85	111	28	9	40	6	0.39	0.60
399	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(13), ACO2(8), CLYBL(10), CS(5), DLD(7), DLST(10), FH(11), IDH1(4), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), OGDH(11), OGDHL(18), PC(8), PCK1(15), PCK2(7), SDHA(12), SDHB(1), SDHC(6), SDHD(1), SUCLA2(5), SUCLG1(1), SUCLG2(14)	10465332	209	55	202	76	53	95	29	13	19	0	0.39	0.60
400	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), ZNRD1(1)	8165674	122	43	120	42	34	47	10	11	20	0	0.39	0.61
401	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(6), B4GALNT1(5), GLB1(9), HEXA(3), HEXB(4), LCT(30), SLC33A1(8), ST3GAL1(2), ST3GAL2(4), ST3GAL5(2), ST6GALNAC3(10), ST6GALNAC4(5), ST6GALNAC5(5), ST6GALNAC6(8), ST8SIA1(4), ST8SIA5(8)	5684376	113	39	110	36	35	44	12	8	14	0	0.39	0.61
402	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(5), IL1B(2), MST1(6), MST1R(17), TNF(1)	2108219	31	19	30	13	12	10	1	1	7	0	0.40	0.61
403	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(7), CHIA(8), CHIT1(5), CMAS(6), CTBS(4), CYB5R1(5), CYB5R3(5), GFPT1(11), GFPT2(12), GNE(8), GNPDA1(3), GNPDA2(5), GNPNAT1(2), HEXA(3), HEXB(4), HK1(13), HK2(8), HK3(12), LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), NAGK(3), NANS(6), NPL(6), PGM3(6), PHPT1(2), RENBP(6), UAP1(8)	9847039	188	50	183	64	45	77	28	13	25	0	0.40	0.61
404	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(12), ICAM1(3), ITGA4(12), ITGAL(13), ITGB1(12), ITGB2(14), SELE(10), SELL(4)	4673645	80	34	78	26	21	32	11	6	10	0	0.41	0.62
405	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(12), AGT(7), AGTR2(8), EDN1(2), EDNRA(6), EDNRB(2), EGF(24), EGFR(20), FOS(6), JUN(1), MYC(7), NFKB1(12), PLCG1(12), PRKCA(10), RELA(6)	7244568	135	43	130	49	33	55	23	8	16	0	0.41	0.62
406	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(7), B3GNT2(4), B3GNT3(2), B3GNT4(5), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT4(3), FUT1(5), FUT2(3), FUT3(9), FUT6(13), FUT9(12), GCNT2(17), ST3GAL6(8), ST8SIA1(4)	4921727	113	35	107	25	27	59	9	6	12	0	0.42	0.63
407	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(3), CDC7(13), CDK2(5), DIAPH2(22), GMNN(3), MCM10(8), MCM2(10), MCM3(9), MCM4(9), MCM5(12), MCM6(9), MCM7(5), NACA(20), PCNA(3), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), PRIM1(2), RFC1(15), RFC2(4), RFC3(4), RFC4(4), RFC5(7), RPA1(6), RPA2(2), RPA3(4), RPA4(6), RPS27A(3), UBB(3), UBC(5)	17156137	229	61	222	57	82	90	21	9	27	0	0.42	0.63
408	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(57), MAP2(27), PPP1CA(6), PPP2CA(6), PRKACB(2), PRKACG(6), PRKAG1(2), PRKAR2A(4), PRKAR2B(5), PRKCE(11)	6468057	126	41	121	36	23	46	24	6	24	3	0.42	0.63
409	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(3), CALM3(1), DLG4(13), GRIN1(5), GRIN2A(25), GRIN2B(23), GRIN2C(6), GRIN2D(8), NOS1(21), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), SYT1(4)	8559307	165	49	160	69	35	74	31	6	17	2	0.42	0.63
410	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(5), DRD1(6), DRD2(10), GRM1(22), PLCB1(6), PPP1CA(6), PPP1R1B(4), PPP2CA(6), PPP3CA(4), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5)	5410482	99	36	97	37	25	42	13	4	13	2	0.43	0.64
411	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(7), FUT1(5), FUT2(3), FUT9(12), GCNT2(17), ST8SIA1(4)	2126144	48	25	45	10	12	24	5	3	4	0	0.43	0.65
412	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(6), SNCA(2), SNCAIP(12), UBE2E2(3), UBE2F(1), UBE2G1(2), UBE2L3(4), UBE2L6(1)	2165818	40	24	40	13	13	17	4	4	2	0	0.44	0.66
413	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(7), PLCD1(5), PRKCA(10), TGM2(9)	1769078	31	22	31	20	10	11	5	3	2	0	0.44	0.66
414	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(13), CTH(5), MUT(7)	1579551	34	21	33	7	8	16	4	1	5	0	0.44	0.66
415	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(5), ABAT(9), ACADS(5), ACAT1(6), ACAT2(5), ACSM1(12), AKR1B10(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH5A1(9), ALDH7A1(2), ALDH9A1(4), BDH1(6), BDH2(6), DDHD1(14), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADH(1), HADHA(7), HMGCL(3), HMGCS1(4), HMGCS2(8), HSD17B10(4), HSD17B4(10), HSD3B7(3), ILVBL(7), L2HGDH(3), OXCT1(10), OXCT2(2), PDHA1(4), PDHA2(10), PDHB(7), PLA1A(5), PPME1(1), PRDX6(2), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	13856981	253	56	244	64	65	113	33	15	23	4	0.45	0.66
416	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(3), BHMT(2), CBS(13), CTH(5), DNMT1(15), DNMT3A(13), DNMT3B(15), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), MTAP(4), MTFMT(1), MTR(13), SRM(1), TAT(9)	6919050	131	42	121	53	32	62	17	3	17	0	0.45	0.66
417	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(4), ABP1(12), ACAT1(6), ACAT2(5), ACMSD(8), AFMID(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AOC2(6), AOC3(14), AOX1(19), ASMT(3), CARM1(6), CAT(5), CYP1A1(9), CYP1A2(6), CYP1B1(3), DDC(11), ECHS1(3), EHHADH(9), GCDH(5), HAAO(4), HADH(1), HADHA(7), HEMK1(2), HSD17B10(4), HSD17B4(10), INMT(4), KMO(11), KYNU(5), LCMT1(4), LCMT2(13), LNX1(9), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), NFX1(14), OGDH(11), OGDHL(18), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), TDO2(3), TPH1(14), TPH2(9), WARS(6), WARS2(5), WBSCR22(9)	20922060	398	70	387	99	95	166	60	25	43	9	0.45	0.67
418	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(4), ADAM17(11), ATP6AP1(7), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1B1(15), ATP6V1B2(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), CASP3(4), CCL5(4), CDC42(5), CHUK(11), CSK(1), CXCL1(1), EGFR(20), F11R(2), GIT1(9), HBEGF(3), IGSF5(9), IKBKB(15), IL8(3), JAM2(9), JAM3(3), JUN(1), LYN(7), MAP2K4(6), MAP3K14(12), MAPK10(9), MAPK13(2), MAPK14(6), MAPK8(7), MAPK9(7), MET(10), NFKB1(12), NFKB2(10), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(27), PTPN11(8), PTPRZ1(43), RELA(6), SRC(2), TCIRG1(8), TJP1(33)	23868691	477	75	468	154	118	205	63	23	64	4	0.47	0.69
419	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(7), ADSS(8), DHFR(3), HPRT1(2), IMPDH1(5), MTHFD2(3), POLB(4), POLD1(15), POLG(7), PRPS2(10), RRM1(4), SRM(1)	4120599	69	33	68	22	16	31	11	5	6	0	0.47	0.69
420	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(6), ALDOB(9), ALDOC(4), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GAPDHS(10), GCK(5), GOT1(6), GOT2(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHAL6B(2), LDHB(2), LDHC(3), MDH1(2), MDH2(5), PC(8), PCK1(15), PDHA1(4), PDHA2(10), PDHB(7), PDHX(8), PFKM(7), PFKP(11), PGAM1(2), PGAM2(2), PGK1(6), PGK2(5), PKLR(10), PKM2(5), TNFAIP1(3), TPI1(1)	13872277	244	57	239	81	69	102	30	16	25	2	0.47	0.69
421	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL15(1), IL16(17), IL18(1), IL1A(1), IL2(4), IL5(2), IL6(2), IL8(3), LTA(3), TNF(1)	3594321	58	28	56	22	16	25	7	2	8	0	0.48	0.70
422	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(10), B3GALT2(8), B3GALT5(6), B3GNT5(6), FUT1(5), FUT2(3), FUT3(9), ST3GAL3(6), ST3GAL4(4)	2575225	57	26	54	16	12	28	7	3	7	0	0.48	0.70
423	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(2), CBS(13), CTH(5), DNMT1(15), DNMT3A(13), DNMT3B(15), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), MTR(13)	5873186	113	38	104	44	26	55	14	2	16	0	0.48	0.70
424	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(8), CS(5), DLAT(2), DLD(7), DLST(10), FH(11), IDH2(7), IDH3A(5), IDH3B(5), IDH3G(9), MDH1(2), MDH2(5), OGDH(11), PC(8), PDHA1(4), PDHA2(10), PDHB(7), PDHX(8), PDK1(7), PDK2(5), PDK3(10), PDK4(7), PDP2(7), SDHA(12), SDHB(1), SDHC(6), SDHD(1), SUCLA2(5), SUCLG1(1), SUCLG2(14)	9849668	200	51	195	66	57	86	24	13	20	0	0.48	0.70
425	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(5), ASL(4), CPS1(24), GLS(10), GLUD1(4), GOT1(6)	2621352	53	24	51	13	12	20	7	2	8	4	0.49	0.71
426	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(6), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), HGSNAT(9), HPSE(4), HPSE2(5), HYAL1(4), HYAL2(1), IDS(6), LCT(30), NAGLU(3), SPAM1(12)	6792858	103	41	101	51	28	45	12	8	10	0	0.49	0.71
427	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AICDA(3), CAD(38), CANT1(5), CDA(1), CTPS(10), CTPS2(10), DCK(4), DCTD(5), DHODH(3), DPYD(16), DPYS(3), DUT(1), ENTPD1(6), ENTPD3(8), ENTPD4(4), ENTPD5(2), ENTPD6(15), ITPA(1), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT2(3), PNPT1(9), POLA1(26), POLD1(15), POLD2(6), POLD3(6), POLD4(1), POLE(1), POLE2(4), POLE3(2), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(2), POLR2A(25), POLR2B(20), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3A(9), POLR3B(7), POLR3G(2), POLR3GL(2), POLR3H(3), PRIM1(2), PRIM2(7), RFC5(7), RRM1(4), RRM2(5), RRM2B(5), TK1(2), TK2(7), TXNRD1(10), TXNRD2(4), TYMS(1), UCK1(5), UCK2(6), UMPS(7), UPB1(9), UPP1(4), UPP2(7), UPRT(6), ZNRD1(1)	27818405	472	81	461	144	110	192	71	32	65	2	0.49	0.71
428	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(3), RAB27A(3), RAB3A(5), RAB4A(5), RAB5A(2), RAB6A(2), RAB9A(7)	1537248	32	18	28	8	9	14	3	0	6	0	0.49	0.71
429	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), DAG1(7), ITPKB(6), ITPR1(31), ITPR2(38), ITPR3(23), NFAT5(13), PDE6A(13), PDE6B(6), PDE6C(14), PDE6D(1), SLC6A13(10), TF(15)	12139049	202	51	199	68	60	85	23	6	26	2	0.50	0.72
430	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(5), ACADL(7), ACADM(6), ACOX1(4), ACOX2(7), ACOX3(8), ACSL1(13), ACSL3(10), ACSL4(24), ACSL5(18), ACSL6(13), ADIPOQ(3), ANGPTL4(1), APOA2(2), APOA5(2), AQP7(6), CD36(7), CPT1A(10), CPT1C(15), CPT2(7), CYP27A1(8), CYP4A11(5), CYP4A22(8), CYP7A1(12), CYP8B1(8), DBI(3), EHHADH(9), FABP1(5), FABP2(1), FABP3(1), FABP5(3), FABP6(3), FABP7(2), FADS2(2), GK(14), GK2(20), HMGCS2(8), ILK(8), LPL(11), ME1(10), MMP1(2), NR1H3(5), OLR1(1), PCK1(15), PCK2(7), PDPK1(3), PLTP(6), PPARA(2), PPARD(6), PPARG(5), RXRA(1), RXRG(10), SCD(9), SCP2(13), SLC27A1(9), SLC27A2(4), SLC27A4(5), SLC27A5(6), SLC27A6(10), SORBS1(22), UBC(5), UCP1(1)	22612507	456	74	442	121	133	186	64	23	48	2	0.50	0.72
431	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), HSD3B7(3), PON1(12), PON2(8), PON3(1), RDH11(3), RDH12(6), RDH13(5), RDH14(3)	3072823	67	30	65	17	21	25	11	3	7	0	0.50	0.72
432	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(3), CD3E(2), CD3G(2)	407734	7	6	7	1	0	4	1	0	2	0	0.51	0.72
433	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(13), CTH(5), GGT1(10), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), PAPSS1(6), PAPSS2(6), SCLY(4), SEPHS1(13)	4130398	94	33	88	29	31	39	14	2	8	0	0.51	0.72
434	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(5), FUT2(3), FUT3(9), FUT6(13), ST3GAL3(6)	1534380	36	20	36	14	4	26	4	1	1	0	0.51	0.72
435	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), GOT1(6), GOT2(5), GPT2(7), MDH1(2), MDH2(5), ME1(10), ME3(7), PGK1(6), PGK2(5), PKLR(10), PKM2(5), RPE(3), RPIA(7), TKT(7), TKTL1(10), TKTL2(12), TPI1(1)	6529241	131	41	128	43	35	57	14	7	16	2	0.51	0.72
436	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(12), ICAM1(3), ITGA4(12), ITGAL(13), ITGAM(24), ITGB1(12), ITGB2(14), SELE(10), SELL(4), SELP(15)	6087091	119	40	114	29	30	50	14	6	17	2	0.52	0.73
437	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(5), ATIC(9), ATP6V0C(2), DHFR(3), GART(8), MTHFD1(6), MTHFD1L(12), MTHFD2(3), MTHFR(7), MTR(13), SHMT1(6), SHMT2(8), TYMS(1)	6300757	92	37	88	32	23	42	9	3	13	2	0.52	0.73
438	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), ELK1(2), FPR1(4), GNA15(1), GNB1(3), MAP2K1(2), MAP2K3(8), MAP2K6(9), MAP3K1(31), MAPK1(2), MAPK14(6), MAPK3(4), NCF1(5), NCF2(6), NFATC2(15), NFATC3(12), NFATC4(8), NFKB1(12), NFKBIA(3), PAK1(3), PIK3C2G(22), PLCB1(6), PPP3CA(4), PPP3CB(7), PPP3CC(6), RAF1(7), RELA(6), SYT1(4)	12974832	216	55	212	53	61	65	35	14	37	4	0.52	0.73
439	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(7), IDI1(4), SQLE(6)	1130709	20	14	20	6	5	5	5	3	2	0	0.52	0.73
440	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(4), AASS(6), ACAT1(6), ACAT2(5), AKR1B10(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), BBOX1(4), DLST(10), DOT1L(8), ECHS1(3), EHHADH(9), EHMT2(6), GCDH(5), HADH(1), HADHA(7), HSD17B10(4), HSD17B4(10), HSD3B7(3), NSD1(36), OGDH(11), OGDHL(18), PIPOX(6), PLOD1(4), PLOD2(16), PLOD3(11), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SETD1A(12), SETD7(6), SETDB1(19), SHMT1(6), SHMT2(8), SPCS1(1), SPCS3(3), SUV39H1(10), SUV39H2(6), TMLHE(5)	19491406	319	68	305	82	78	134	49	19	35	4	0.52	0.73
441	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(6), ARSD(9), ARSE(7), ASAH1(9), GAL3ST1(13), GALC(7), GBA(4), GLA(3), GLB1(9), LCT(30), NEU2(5), NEU3(3), PPAP2A(4), PPAP2B(3), SMPD1(12), SMPD2(5), SPTLC1(6), SPTLC2(6), UGCG(5)	7860710	146	43	145	44	43	68	12	9	14	0	0.52	0.73
442	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(3), CD3E(2), CD3G(2), CD4(8), FYN(7), HLA-DRB1(1), LCK(5), PTPRC(15), ZAP70(10)	3184675	53	27	53	15	11	25	5	2	10	0	0.53	0.73
443	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(27), ACADL(7), ACADM(6), ACADSB(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), LDHA(6), LDHB(2), LDHC(3), MLYCD(5), MUT(7), PCCA(10), PCCB(8), SDS(3), SUCLA2(5), SUCLG1(1), SUCLG2(14)	11463157	188	50	185	52	49	67	33	15	24	0	0.53	0.73
444	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(9), F2R(8), GNAI1(4), GNB1(3), ITGA1(20), ITGB1(12), MAP2K1(2), MAPK1(2), MAPK3(4), PLA2G4A(11), PLCB1(6), PRKCA(10), PTGS1(8), PTK2(11), RAF1(7), SRC(2), SYK(6), TBXAS1(6)	8327716	131	44	129	43	34	51	20	7	19	0	0.53	0.73
445	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(27), CPT1A(10), LEP(2), LEPR(15), PRKAA1(6), PRKAA2(9), PRKAB1(7), PRKAB2(2), PRKAG1(2), PRKAG2(4)	5100499	84	34	82	25	22	33	9	5	15	0	0.53	0.74
446	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(4), ABP1(12), ACAT1(6), ACAT2(5), ACMSD(8), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), AOC2(6), AOC3(14), AOX1(19), ASMT(3), CAT(5), CYP19A1(12), CYP1A1(9), CYP1A2(6), CYP2A13(7), CYP2A6(11), CYP2A7(5), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2D6(2), CYP2E1(5), CYP2F1(5), CYP2J2(5), CYP3A4(14), CYP3A5(7), CYP3A7(9), CYP4B1(4), CYP4F8(9), CYP51A1(4), DDC(11), ECHS1(3), EHHADH(9), GCDH(5), HAAO(4), HADHA(7), KMO(11), KYNU(5), MAOA(14), MAOB(7), SDS(3), TDO2(3), TPH1(14), WARS(6), WARS2(5)	19356132	371	67	364	108	101	139	59	22	43	7	0.54	0.74
447	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(12), ACADM(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AOC2(6), AOC3(14), CNDP1(6), DPYD(16), DPYS(3), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), HIBCH(7), MLYCD(5), SMS(8), SRM(1), UPB1(9)	9239023	164	47	159	46	48	58	26	12	20	0	0.54	0.74
448	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(4), GPLD1(10), PGAP1(11), PIGA(8), PIGB(10), PIGC(4), PIGF(4), PIGG(12), PIGH(3), PIGK(6), PIGL(1), PIGN(9), PIGO(15), PIGP(2), PIGS(3), PIGT(10), PIGU(3), PIGV(6), PIGW(8), PIGX(2), PIGZ(6)	8032790	137	45	135	24	37	56	20	8	16	0	0.54	0.74
449	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(19), AGT(7), AGTR2(8), CMA1(1), COL4A1(23), COL4A2(11), COL4A3(24), COL4A4(24), COL4A5(27), COL4A6(35), REN(3)	9026552	182	47	174	50	47	78	16	10	23	8	0.54	0.74
450	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	AANAT(4), ACHE(4), CHAT(1), DBH(12), DDC(11), GAD1(8), GAD2(12), HDC(10), MAOA(14), PAH(1), PNMT(3), TPH1(14)	4650223	94	34	93	17	20	32	21	1	18	2	0.55	0.75
451	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(6), ERCC3(11), GTF2B(5), GTF2E1(4), GTF2E2(5), GTF2F2(1), GTF2H1(8), GTF2H2(3), GTF2H4(2), ILK(8), MNAT1(2), POLR1A(15), POLR1B(16), POLR2A(25), POLR2B(20), POLR2C(5), POLR2E(1), POLR2F(2), POLR2H(3), POLR2K(2), POLR3B(7), POLR3D(3), POLR3E(5), POLR3H(3), TAF12(1), TAF5(6), TAF6(8), TAF7(3), TAF9(2), TBP(5)	12365860	190	52	183	68	41	81	21	15	32	0	0.56	0.77
452	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), NCK1(4), NCKAP1(10), NTRK1(11), PIR(4), WASF1(3), WASF2(5), WASF3(9), WASL(8)	5403073	82	35	82	32	27	34	6	3	12	0	0.57	0.78
453	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(13), CKM(3), EIF4E(4), FBL(4), LDHA(6), LDHB(2), LDHC(3), MAPK14(6), NCL(2)	2977223	43	27	43	21	11	15	7	5	3	2	0.58	0.78
454	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(5), GLS(10), GLUD1(4), OAT(7)	1641930	28	19	26	10	5	13	5	1	4	0	0.58	0.79
455	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(11), DLG4(13), EPHB2(10), F2(9), F2RL1(3), F2RL2(3), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(17), MAPK8(7), MYEF2(6), PLD1(16), PLD2(7), PLD3(3), PTK2(11), RAF1(7), RASAL1(14), SRC(2), TEC(5), VAV1(16)	9304748	165	48	160	58	43	69	26	5	20	2	0.58	0.79
456	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM2(3), CALM3(1), CCL4(1), CXCL12(3), CXCR4(1), FOS(6), JUN(1), MAPK14(6), MAPK8(7), PLCG1(12), PRKCA(10), PTK2B(16), SYT1(4)	4564422	71	33	69	32	20	24	9	8	10	0	0.59	0.79
457	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(3), ALDH18A1(13), ARG1(5), ARG2(6), ASL(4), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), GATM(8), GLUD1(4), OAT(7), ODC1(3), OTC(8), SMS(8)	5381563	108	36	104	35	27	46	16	5	10	4	0.59	0.80
458	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	FAU(1), MRPS7(6), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL14(2), RPL18(4), RPL18A(4), RPL19(4), RPL21(2), RPL22L1(3), RPL23A(3), RPL24(3), RPL27(1), RPL27A(1), RPL28(2), RPL29(3), RPL3(5), RPL30(2), RPL31(1), RPL35(1), RPL35A(2), RPL36A(1), RPL36AL(1), RPL37(3), RPL38(1), RPL39(5), RPL3L(3), RPL6(2), RPL7(2), RPL8(1), RPL9(1), RPS10(2), RPS12(3), RPS13(1), RPS15A(1), RPS18(4), RPS20(3), RPS21(2), RPS24(4), RPS25(1), RPS27(2), RPS29(2), RPS3(2), RPS3A(2), RPS5(1), RPS6(6), RPS7(3), RPS8(5), RPS9(1), RPSA(1)	7508663	130	42	126	38	28	64	21	4	13	0	0.59	0.80
459	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(10), F11(10), F12(3), F13B(13), F2(9), F5(46), F7(2), F8(41), F9(11), FGA(30), FGB(6), FGG(12), LPA(14), PLAT(6), PLAU(5), PLG(13), SERPINB2(9), SERPINE1(5), SERPINF2(5), VWF(31)	12089576	281	53	269	73	83	112	44	13	25	4	0.60	0.80
460	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(7), ACTR3(3), ARHGAP1(2), ARHGAP4(15), ARHGAP5(24), ARHGAP6(13), ARHGEF1(11), ARHGEF11(22), ARHGEF5(11), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), BAIAP2(1), CFL1(1), DIAPH1(11), GSN(5), LIMK1(7), MYL2(1), MYLK(17), OPHN1(13), PFN1(1), PIP5K1A(7), PIP5K1B(6), PPP1R12B(18), ROCK1(27), SRC(2), TLN1(28), VCL(14)	16054825	281	63	274	79	89	106	29	18	31	8	0.60	0.80
461	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(12), NFKBIA(3), PLCB1(6), PRKCA(10), RELA(6)	2891900	37	23	37	16	4	13	10	4	6	0	0.60	0.80
462	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(4), CANX(8), CD4(8), CD74(1), CD8A(3), CD8B(1), CIITA(21), CREB1(5), CTSB(1), CTSL1(7), CTSS(6), HLA-A(5), HLA-B(3), HLA-DMA(4), HLA-DMB(2), HLA-DOA(3), HLA-DOB(4), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(2), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(3), HLA-G(3), HSP90AA1(7), HSP90AB1(20), HSPA5(8), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), KIR2DL1(6), KIR2DL3(2), KIR2DL4(3), KIR2DS4(6), KIR3DL1(7), KIR3DL2(7), KIR3DL3(3), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(3), KLRD1(2), LGMN(8), LTA(3), NFYA(7), NFYB(2), NFYC(1), PDIA3(6), PSME1(2), PSME2(2), RFX5(13), RFXANK(4), RFXAP(1), TAP1(7), TAP2(2), TAPBP(5)	16547882	278	58	272	69	80	119	31	10	36	2	0.61	0.81
463	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(8), CS(5), FH(11), IDH2(7), MDH1(2), OGDH(11), SDHA(12), SUCLA2(5)	3326163	61	28	60	26	17	30	6	4	4	0	0.61	0.81
464	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(6), GPR161(3), GPR171(6), GPR18(2), GPR34(6), GPR39(10), GPR45(7), GPR65(10), GPR68(4), GPR75(10)	3491073	69	28	65	31	16	28	18	3	4	0	0.61	0.81
465	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(12), AOC2(6), AOC3(14), CES1(12), ESD(2)	2205970	46	23	43	15	13	16	10	3	4	0	0.61	0.81
466	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(5), ATIC(9), DHFR(3), GART(8), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(3), MTHFR(7), MTR(13), SHMT1(6), SHMT2(8), TYMS(1)	6443201	91	36	87	32	22	42	9	3	13	2	0.62	0.81
467	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGK1(6), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	16614324	284	61	278	94	83	116	34	16	33	2	0.62	0.81
468	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), GAPDH(2), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGK1(6), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	16614324	284	61	278	94	83	116	34	16	33	2	0.62	0.81
469	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), GOT1(6), GOT2(5), GPT2(7), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PGK1(6), PKLR(10), PKM2(5), RPE(3), RPIA(7), TKT(7), TPI1(1)	5828254	111	37	109	37	31	47	13	6	12	2	0.62	0.81
470	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(16), MTMR2(4), MTMR6(8), NFS1(8), PHPT1(2), THTPA(1), TPK1(2)	2210750	43	22	41	18	7	17	8	1	10	0	0.62	0.81
471	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(12), CLOCK(11), CRY1(6), CRY2(4), CSNK1E(10), PER1(15)	2749217	58	24	57	17	16	20	10	2	8	2	0.62	0.81
472	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(15), POLD2(6), POLE(1), POLG(7), POLL(8), POLQ(23)	5901627	64	36	63	15	15	29	9	4	7	0	0.62	0.81
473	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(13), G6PD(3), GCLC(8), GCLM(3), GGT1(10), GPX3(4), GPX5(7), GPX6(6), GPX7(1), GSR(5), GSS(5), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTA5(2), GSTK1(5), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), IDH1(4), IDH2(7), MGST1(3), MGST3(1), TXNDC12(5)	7001266	129	43	122	48	49	41	18	11	8	2	0.62	0.81
474	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ALDH4A1(2), ARG1(5), ARG2(6), ASL(4), ASS1(3), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), DAO(5), EPRS(11), GATM(8), GLUD1(4), GLUD2(9), GOT1(6), GOT2(5), LAP3(7), NOS1(21), NOS3(11), OAT(7), OTC(8), P4HA1(8), P4HA2(10), P4HA3(5), PARS2(4), PYCR2(3), PYCRL(1), RARS(11), RARS2(7)	11471044	210	52	204	79	48	98	32	10	18	4	0.62	0.81
475	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(14), EIF2AK4(12), EIF2B5(6), EIF2S1(1), EIF2S2(5), EIF2S3(6), EIF5(3), GSK3B(11), PPP1CA(6)	4058459	64	32	63	16	16	27	5	5	11	0	0.63	0.81
476	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(4), ATF3(4), CYR61(3), DUSP14(3), EIF4E(4), HBEGF(3), IFNG(5), IFRD1(10), IL18(1), IL1A(1), IL1R1(5), MYOG(1), NR4A3(10), WDR1(10)	3627542	68	29	67	20	23	24	13	2	6	0	0.63	0.81
477	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(17), CALM2(3), CALM3(1), CREB1(5), ELK1(2), FOS(6), GNAI1(4), GNAS(25), GNB1(3), JUN(1), MAP2K1(2), MAPK3(4), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PRKCA(10), RAF1(7), RPS6KA3(17), SYT1(4)	11446188	204	52	197	60	57	79	23	14	29	2	0.63	0.81
478	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(6), FARSB(7), GOT1(6), GOT2(5), PAH(1), TAT(9), YARS(8), YARS2(3)	3071867	47	25	46	14	14	17	9	4	3	0	0.63	0.81
479	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(4), LDLR(12), MBTPS1(13), MBTPS2(15), SCAP(16), SREBF1(6), SREBF2(10)	3548194	76	30	75	20	21	34	7	4	10	0	0.63	0.81
480	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ACCN1(4), ADCY4(8), ADCY6(16), ADCY8(16), CACNA1A(19), CACNA1B(1), GNAS(25), GNAT3(7), GNB1(3), GNB3(4), GNG13(2), GNG3(3), GRM4(16), ITPR3(23), KCNB1(17), PDE1A(12), PLCB2(9), PRKACA(4), PRKACB(2), PRKACG(6), PRKX(4), SCNN1A(5), SCNN1B(6), SCNN1G(13), TAS1R1(11), TAS1R2(12), TAS2R1(4), TAS2R10(6), TAS2R13(4), TAS2R14(6), TAS2R16(3), TAS2R3(2), TAS2R38(4), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(2), TAS2R42(5), TAS2R46(1), TAS2R5(5), TAS2R50(4), TAS2R60(7), TAS2R7(4), TAS2R8(6), TAS2R9(1)	18971820	329	60	322	123	91	141	42	17	38	0	0.64	0.82
481	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(4), APAF1(19), CASP3(4), CASP9(3), CYCS(3), DAXX(11), FAS(7), FASLG(6), HSPB2(1), IL1A(1), MAPKAPK2(6), MAPKAPK3(4), TNF(1)	3808943	70	30	69	20	19	25	11	5	10	0	0.64	0.82
482	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(5), ENO2(3), ENO3(4), FARS2(2), GOT1(6), GOT2(5), PAH(1), TAT(9), YARS(8)	2926077	43	23	42	14	9	19	6	4	5	0	0.66	0.84
483	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(7), LIPT1(5)	529863	12	9	12	3	2	7	2	0	1	0	0.66	0.84
484	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(8), ADRBK2(10), ARRB2(3), CALM2(3), CALM3(1), CALML6(4), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CLCA1(20), CLCA2(13), CLCA4(16), CNGA3(13), CNGA4(11), CNGB1(14), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(3), PDE1C(14), PRKACA(4), PRKACB(2), PRKACG(6), PRKG1(9), PRKG2(10), PRKX(4)	10456011	207	51	204	85	54	85	31	7	28	2	0.66	0.84
485	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(5), ASNS(9), ASRGL1(2), CA1(4), CA12(3), CA13(2), CA14(4), CA2(5), CA3(4), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(5), CA8(5), CA9(8), CPS1(24), CTH(5), GLS(10), GLS2(9), GLUD1(4), GLUD2(9), GLUL(6), HAL(6)	7353074	142	41	136	47	46	55	16	4	17	4	0.66	0.84
486	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(13), ACTN2(9), ACTN3(10), CAPN1(4), CAPNS1(3), CAPNS2(6), ITGA1(20), ITGB1(12), ITGB3(16), PTK2(11), PXN(6), SPTAN1(29), SRC(2), TLN1(28)	9938815	173	48	169	72	60	70	13	6	24	0	0.66	0.84
487	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(12), ACY1(3), ADC(8), AGMAT(3), ALDH18A1(13), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), AMD1(3), AOC2(6), AOC3(14), ARG1(5), ARG2(6), ASL(4), ASS1(3), CPS1(24), GATM(8), MAOA(14), MAOB(7), ODC1(3), OTC(8), SAT1(12), SMS(8), SRM(1)	10010037	188	48	180	66	56	76	23	8	21	4	0.66	0.84
488	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(7), SUCLA2(5)	754762	12	10	11	2	2	9	0	0	1	0	0.66	0.84
489	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(4), AASS(6), KARS(7)	1653641	23	16	22	10	7	7	6	2	1	0	0.67	0.84
490	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(17), CREM(5), FHL5(6), FSHR(17), GNAS(25), XPO1(15)	3133290	85	28	81	18	24	42	11	3	5	0	0.67	0.84
491	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(5), CFL1(1), GNAS(25), GNB1(3), LIMK1(7), MAP2K1(2), MAPK1(2), MAPK3(4), MYL2(1), NOX1(11), PIK3C2G(22), PLCB1(6), PPP1R12B(18), PRKCA(10), PTK2(11), RAF1(7), ROCK2(15)	8758155	150	44	147	41	40	52	21	8	25	4	0.67	0.84
492	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(11), DLL1(8), FURIN(5), PSEN1(4)	1751631	28	18	28	20	6	16	1	2	3	0	0.67	0.84
493	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(9), BFAR(9), BRAF(12), CAMP(1), CREB1(5), CREB3(2), CREB5(6), MAPK1(2), RAF1(7), SNX13(12), SRC(2), TERF2IP(4)	3966205	71	30	71	14	11	28	14	6	12	0	0.67	0.84
494	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(6), CD86(6), HLA-DRB1(1), IFNG(5), IFNGR1(6), IFNGR2(4), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18(1), IL18R1(5), IL2(4), IL2RA(3), IL4R(6)	4512559	84	33	82	19	20	35	9	8	12	0	0.68	0.84
495	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(12), NR0B2(2), NR1H3(5), NR1H4(8), RXRA(1)	1845319	31	21	31	11	8	16	4	0	3	0	0.68	0.84
496	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(9), IARS(13), LARS(23), LARS2(9), PDHA1(4), PDHA2(10), PDHB(7)	3562056	75	27	75	14	15	34	11	4	11	0	0.68	0.85
497	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(2), BLVRB(1), CP(12), CPOX(8), EPRS(11), FECH(5), GUSB(5), HCCS(2), HMBS(7), HMOX1(3), HMOX2(5), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10), UROD(2), UROS(3)	9137926	139	43	133	39	42	57	17	7	16	0	0.68	0.85
498	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(12), CLOCK(11), CRY1(6), CRY2(4), CSNK1E(10), NPAS2(10), NR1D1(3), PER1(15), PER2(8), PER3(16)	5595468	95	35	91	27	28	33	14	3	15	2	0.69	0.85
499	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(4), ARFGAP1(3), ARFGAP3(6), ARFGEF2(30), CLTA(1), CLTB(5), COPA(14), GBF1(23), GPLD1(10), KDELR1(3), KDELR2(2), KDELR3(4)	5507994	105	35	105	25	20	50	14	5	14	2	0.70	0.86
500	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(13), G6PD(3), GCLC(8), GCLM(3), GGT1(10), GPX3(4), GPX5(7), GSS(5), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), IDH1(4), IDH2(7), MGST1(3), MGST3(1), PGD(4)	6272794	109	40	104	41	41	36	14	11	5	2	0.70	0.86
501	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(4), CASP7(4), DFFA(1), DFFB(3), GZMB(2), HMGB1(2), HMGB2(3), TOP2A(15), TOP2B(21)	3519275	55	27	55	21	5	17	13	7	13	0	0.70	0.86
502	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(6), CBS(13), CTH(5), GGT1(10), HEMK1(2), LCMT1(4), LCMT2(13), MARS(12), MARS2(7), MAT1A(2), MAT2B(12), METTL2B(3), METTL6(2), PAPSS1(6), PAPSS2(6), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), SCLY(4), SEPHS1(13), SEPHS2(4), WBSCR22(9)	8352572	177	41	169	45	53	71	23	7	19	4	0.70	0.86
503	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(11), GTF2A1(5), GTF2B(5), GTF2E1(4), GTF2F1(6), HDAC3(10), NCOA1(17), NCOA2(16), NCOA3(8), NCOR2(24), POLR2A(25), RARA(3), RXRA(1), TBP(5)	8039721	140	41	137	55	27	68	23	7	15	0	0.70	0.86
504	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(4), GBA3(9), GGT1(10), SHMT1(6), SHMT2(8)	1968643	39	20	36	13	12	14	4	1	6	2	0.70	0.86
505	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(5), CALCRL(9), CD97(8), CRHR1(2), CRHR2(2), ELTD1(12), EMR1(22), EMR2(5), GHRHR(2), GIPR(4), GLP1R(8), GLP2R(17), GPR64(10), LPHN1(16), LPHN2(30), LPHN3(29), SCTR(4), VIPR1(3)	9426160	195	48	190	57	43	93	23	14	20	2	0.71	0.86
506	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(1), LCT(30), MPI(5), PGM1(9), PYGL(9), PYGM(10), TPI1(1), TREH(4)	4675557	82	30	82	33	19	36	11	8	8	0	0.71	0.86
507	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPS(10), CDIPT(1), CDS1(3), CDS2(2), CHAT(1), CHKA(8), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), ETNK1(9), GNPAT(11), GPD1(6), GPD2(5), LCAT(2), LGALS13(2), LYPLA1(2), LYPLA2(5), PAFAH1B1(1), PAFAH2(6), PCYT1A(7), PCYT1B(4), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLCB2(9), PLCG1(12), PLCG2(27), PPAP2A(4), PPAP2B(3)	16172413	282	62	278	93	74	108	44	21	31	4	0.71	0.87
508	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(13), ACO2(8), CS(5), GRHPR(4), HAO1(2), HAO2(7), HYI(2), MDH1(2), MDH2(5), MTHFD1(6), MTHFD1L(12), MTHFD2(3)	4485313	69	33	68	28	24	26	9	5	5	0	0.72	0.87
509	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(5), ADORA2B(2), ADORA3(5), LTB4R(3), P2RY1(2), P2RY2(6), P2RY6(3)	2001147	32	21	32	14	9	9	10	4	0	0	0.72	0.87
510	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(12), ACY3(4), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH7A1(2), ALDH9A1(4), AMDHD1(9), AOC2(6), AOC3(14), ASPA(5), CARM1(6), CNDP1(6), DDC(11), HAL(6), HARS(4), HARS2(8), HDC(10), HEMK1(2), HNMT(5), LCMT1(4), LCMT2(13), MAOA(14), MAOB(7), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), PRPS1(3), PRPS2(10), UROC1(14), WBSCR22(9)	13349823	263	53	257	73	72	99	37	15	36	4	0.72	0.87
511	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(9), ALG10B(8), ALG11(6), ALG12(1), ALG13(17), ALG14(2), ALG2(2), ALG3(5), ALG5(4), ALG6(5), ALG8(8), ALG9(6), B4GALT1(2), B4GALT2(5), B4GALT3(8), DAD1(1), DDOST(3), DHDDS(8), DOLPP1(1), DPAGT1(4), DPM1(2), FUT8(13), GANAB(13), MAN1A1(11), MAN1A2(9), MAN1B1(4), MAN1C1(7), MAN2A1(23), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), MGAT5B(7), RFT1(6), RPN1(6), RPN2(9), ST6GAL1(10), STT3B(6)	14360076	262	58	245	64	65	109	41	9	34	4	0.73	0.88
512	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	259076	5	3	5	2	1	3	0	1	0	0	0.73	0.88
513	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(37), RANGAP1(5)	2882340	43	23	43	7	9	14	9	1	10	0	0.73	0.88
514	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(7), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT5(2), FUT8(13), ST3GAL1(2), ST3GAL2(4), ST3GAL3(6), ST3GAL4(4)	2606056	53	25	48	17	15	25	9	0	4	0	0.73	0.88
515	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMC3(1), PSMD14(3), RPN1(6), RPN2(9), UBE2A(4), UBE3A(13)	4635883	75	30	71	24	14	32	11	3	15	0	0.74	0.88
516	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(12), ALAS2(11), BLVRA(2), BLVRB(1), COX10(5), COX15(4), CP(12), CPOX(8), EARS2(4), EPRS(11), FECH(5), FTH1(2), FTMT(7), GUSB(5), HCCS(2), HMBS(7), HMOX1(3), HMOX2(5), MMAB(2), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), UROD(2), UROS(3)	13992494	264	53	254	65	79	107	38	13	27	0	0.74	0.88
517	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(11), AASDHPPT(4), AASS(6), KARS(7)	2455008	34	22	33	16	12	9	8	2	3	0	0.74	0.88
518	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(12), ACADL(7), ACADM(6), ACADSB(4), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), AOC2(6), AOC3(14), CNDP1(6), DPYD(16), DPYS(3), ECHS1(3), EHHADH(9), GAD1(8), GAD2(12), HADHA(7), MLYCD(5), SDS(3), SMS(8), UPB1(9)	10047799	183	49	178	64	52	63	29	15	24	0	0.74	0.88
519	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), AKR1B10(4), ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), FPGT(5), FUK(8), GMDS(3), GMPPA(9), GMPPB(3), HK1(13), HK2(8), HK3(12), HSD3B7(3), KHK(1), LHPP(2), MPI(5), MTMR1(16), MTMR2(4), MTMR6(8), PFKFB1(9), PFKFB2(1), PFKFB3(7), PFKFB4(4), PFKM(7), PFKP(11), PGM2(6), PHPT1(2), PMM1(1), PMM2(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SORD(3), TPI1(1), TSTA3(4)	12021700	208	55	202	71	56	86	25	14	25	2	0.74	0.88
520	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(6), ALDOB(9), ALDOC(4), DERA(9), FBP1(4), G6PD(3), GPI(9), H6PD(5), PFKM(7), PFKP(11), PGD(4), PGLS(1), PGM1(9), PGM3(6), PRPS1(3), PRPS1L1(5), PRPS2(10), RBKS(1), RPE(3), RPIA(7), TALDO1(6), TKT(7), TKTL1(10), TKTL2(12)	7865729	151	45	143	50	40	67	17	8	17	2	0.75	0.88
521	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(3), CALM3(1), CAMK1(9), CAMK1G(5), CAMK2A(8), CAMK2B(2), CAMK2D(7), CAMK2G(8), CAMK4(5), CAMKK1(8), CAMKK2(6), CREB1(5), SYT1(4)	3825434	71	30	69	11	16	31	7	4	13	0	0.75	0.88
522	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(9), CYP51A1(4), DHCR24(6), DHCR7(4), FDFT1(3), FDPS(7), GGCX(10), GGPS1(2), HMGCR(15), HSD17B7(4), IDI1(4), IDI2(2), MVD(3), MVK(7), NQO1(3), NSDHL(9), PMVK(2), SC4MOL(3), SC5DL(3), SQLE(6), TM7SF2(3), VKORC1(3)	6305059	112	34	111	49	31	42	17	8	14	0	0.75	0.89
523	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7)	2015487	42	21	41	7	11	15	10	0	6	0	0.75	0.89
524	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(5), ALG5(4), B4GALT1(2), B4GALT2(5), B4GALT3(8), B4GALT5(2), DDOST(3), DPAGT1(4), DPM1(2), FUT8(13), MAN1A1(11), MAN1B1(4), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(4), MGAT4B(7), MGAT5(9), RPN1(6), RPN2(9), ST6GAL1(10)	6557682	117	37	109	31	36	46	20	2	13	0	0.76	0.89
525	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(7), GGPS1(2), IDI1(4), IDI2(2), SQLE(6)	1516694	24	16	24	10	6	8	5	3	2	0	0.76	0.89
526	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(4), ACSS2(11), ACYP1(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1A1(1), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH7A1(2), ALDH9A1(4), ALDOA(6), ALDOB(9), ALDOC(4), BPGM(2), DLAT(2), DLD(7), ENO1(5), ENO2(3), ENO3(4), FBP1(4), G6PC(6), G6PC2(9), GAPDH(2), GAPDHS(10), GCK(5), GPI(9), HK1(13), HK2(8), HK3(12), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), PDHA1(4), PDHA2(10), PDHB(7), PFKM(7), PFKP(11), PGAM1(2), PGAM2(2), PGK1(6), PGK2(5), PGM1(9), PGM3(6), PKLR(10), PKM2(5), TPI1(1)	19211776	325	62	318	106	97	131	42	20	31	4	0.76	0.89
527	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(5), ASNS(9), CA1(4), CA12(3), CA14(4), CA2(5), CA3(4), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(5), CA8(5), CA9(8), CPS1(24), CTH(5), GLS(10), GLS2(9), GLUD1(4), GLUL(6), HAL(6)	6613130	129	39	123	36	42	47	15	4	17	4	0.76	0.89
528	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(7), ACTR3(3), ARPC1A(7), ARPC1B(3), ARPC2(2), ARPC3(2), CDC42(5), WASF1(3), WASL(8)	2884252	44	23	44	13	15	18	2	0	9	0	0.76	0.89
529	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(12), CSF1(5), FCGR3A(2), IL1B(2), IL6R(12), SELL(4), SPN(4), TGFB1(4), TGFB2(6), TNF(1), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(8), TNFSF8(1)	4599794	84	30	81	21	26	28	16	4	10	0	0.76	0.89
530	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(7), FOS(6), FYN(7), JUN(1), MAPK14(6), THBS1(12)	2603188	43	22	43	11	12	18	4	4	5	0	0.76	0.89
531	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(5), ACOT11(6), ACYP1(2), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ECHS1(3), EHHADH(9), ESCO1(11), ESCO2(6), GCDH(5), HADHA(7), ITGB1BP3(1), NAT6(2), PNPLA3(6), SH3GLB1(8), YOD1(2)	8986878	101	39	101	38	27	46	13	4	11	0	0.77	0.89
532	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1C1(5), AKR1C2(3), AKR1C3(3), AKR1C4(5), ALDH3A1(6), ALDH3B1(5), ALDH3B2(8), CYP1A1(9), CYP1A2(6), CYP1B1(3), CYP2B6(11), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(5), CYP2E1(5), CYP2F1(5), CYP2S1(8), CYP3A4(14), CYP3A43(5), CYP3A5(7), CYP3A7(9), DHDH(3), EPHX1(2), GSTA1(5), GSTA2(6), GSTA3(3), GSTA4(3), GSTA5(2), GSTK1(5), GSTM1(3), GSTM2(1), GSTM3(4), GSTM4(2), GSTM5(2), GSTO2(2), GSTP1(2), GSTZ1(4), MGST1(3), MGST3(1), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10)	19472525	384	66	369	86	106	161	61	20	36	0	0.78	0.90
533	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(2), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AKR1C4(5), AKR1D1(8), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), BAAT(7), CEL(6), CYP27A1(8), CYP7A1(12), HADHB(5), SOAT2(8), SRD5A1(4), SRD5A2(4)	8060036	152	42	147	43	47	55	25	8	17	0	0.78	0.90
534	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(13), ACO2(8), ACSS1(4), ACSS2(11), FH(11), IDH1(4), IDH2(7), MDH1(2), MDH2(5), SUCLA2(5)	4691092	79	32	78	36	22	35	6	7	7	2	0.79	0.91
535	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(2), ACAT1(6), ACAT2(5), ECHS1(3), EHHADH(9), HADHA(7), HADHB(5), SDS(3)	2850075	45	22	45	13	10	20	8	5	2	0	0.79	0.91
536	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(6), SNAP25(7), STX1A(2)	1149112	21	17	20	7	8	7	4	1	1	0	0.79	0.91
537	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(7), ACADM(6), ACADS(5), ACAT1(6), ECHS1(3), HADHA(7)	1813293	34	18	33	14	3	20	5	3	3	0	0.80	0.91
538	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(3), HADH(1), HADHA(7), HADHB(5), HSD17B10(4), HSD17B4(10), MECR(6), PPT1(6), PPT2(3)	2893812	47	23	45	11	6	24	7	6	4	0	0.80	0.91
539	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(14), ACE2(19), AGT(7), AGTR2(8), ANPEP(13), CMA1(1), CPA3(5), CTSA(7), CTSG(3), ENPEP(13), LNPEP(9), MAS1(2), MME(8), NLN(4), REN(3)	7026122	116	38	112	47	36	38	18	6	14	4	0.80	0.91
540	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), CSF3(1), EPO(2), FLT3(9), IGF1(3), IL1A(1), IL6(2), KITLG(2), TGFB1(4), TGFB2(6), TGFB3(9)	2884730	40	22	40	13	10	18	4	1	7	0	0.80	0.91
541	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(27), ACACB(31), ACAT1(6), ACAT2(5), ACOT12(10), ACSS1(4), ACSS2(11), ACYP1(2), AKR1B1(2), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), DLAT(2), DLD(7), GRHPR(4), HAGH(2), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(2), LDHC(3), LDHD(3), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PC(8), PCK1(15), PCK2(7), PDHA1(4), PDHA2(10), PDHB(7), PKLR(10), PKM2(5)	15880833	257	60	249	91	70	107	30	11	35	4	0.81	0.91
542	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(3), CD3E(2), CD3G(2), CXCR3(5), ETV5(10), IFNG(5), IL12A(7), IL12B(3), IL12RB1(16), IL12RB2(11), IL18(1), IL18R1(5), JAK2(21), JUN(1), MAP2K6(9), MAPK14(6), MAPK8(7), STAT4(9), TYK2(7)	6381539	130	36	127	25	26	50	17	14	17	6	0.81	0.91
543	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(6), ALOX15(12), ALOX15B(12), ALOX5(7), ALOX5AP(4), GGT1(10), LTA4H(6), PLA2G6(6), PTGDS(6), PTGES(2), PTGIS(8), PTGS1(8), PTGS2(7), TBXAS1(6)	4640424	100	32	98	26	27	47	13	3	10	0	0.81	0.91
544	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CYP2C19(7), CYP2C9(5), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ECHS1(3), EHHADH(9), ESCO1(11), ESCO2(6), HADHA(7), NAT6(2), PNPLA3(6), SH3GLB1(8), YOD1(2)	10656293	117	40	116	47	40	48	11	6	12	0	0.81	0.91
545	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), RPE(3), UCHL1(5), UCHL3(1), UGDH(3), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2B15(9), UGT2B4(10)	5675055	89	33	85	16	31	32	12	5	9	0	0.82	0.92
546	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(4), ATG5(3), ATG7(6), GABARAP(2), GABARAPL1(2), IFNA10(2), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(2), IFNA4(3), IFNA5(2), IFNA6(6), IFNA7(2), IFNA8(2), IFNG(5), PIK3C3(11), PIK3R4(25), PRKAA1(6), PRKAA2(9), ULK2(10), ULK3(5)	6746014	119	37	118	37	32	49	19	7	12	0	0.82	0.92
547	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(19), PDXK(3), PDXP(1), PNPO(4), PSAT1(5)	1614923	32	18	32	11	10	12	5	1	4	0	0.82	0.93
548	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(5), GTF2A1L(2), GTF2B(5), GTF2E1(4), GTF2E2(5), GTF2F1(6), GTF2F2(1), GTF2H1(8), GTF2H2(3), GTF2H3(3), GTF2H4(2), GTF2I(5), GTF2IRD1(15), STON1(2), TAF1(40), TAF10(1), TAF12(1), TAF1L(41), TAF2(17), TAF4(7), TAF4B(11), TAF5(6), TAF5L(4), TAF6(8), TAF6L(8), TAF7(3), TAF7L(10), TAF9(2), TBPL1(4), TBPL2(4)	12706674	233	48	229	66	58	101	34	11	27	2	0.83	0.93
549	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(2), ACAD8(7), ACAD9(10), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AKR1B10(4), AKR1C4(5), AKR1D1(8), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), BAAT(7), CEL(6), CYP27A1(8), CYP7A1(12), HADHB(5), HSD3B7(3), LIPA(6), RDH11(3), RDH12(6), RDH13(5), RDH14(3), SLC27A5(6), SOAT1(10), SOAT2(8), SRD5A1(4), SRD5A2(4)	10858009	205	48	200	50	60	80	31	10	22	2	0.83	0.93
550	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(19), CD38(7), ENPP1(11), ENPP3(16), NADSYN1(12), NMNAT1(4), NMNAT2(2), NNMT(7), NNT(9), NT5C(1), NT5E(6), NT5M(4)	5019239	98	34	94	20	22	43	20	7	6	0	0.83	0.93
551	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), FPGT(5), GCK(5), GMDS(3), GMPPA(9), GMPPB(3), HK1(13), HK2(8), HK3(12), KHK(1), MPI(5), PFKFB1(9), PFKFB3(7), PFKFB4(4), PFKM(7), PFKP(11), PMM1(1), PMM2(6), SORD(3), TPI1(1)	8193876	138	43	135	46	39	60	14	11	12	2	0.83	0.93
552	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(12), AZIN1(3), CBX3(5), CLOCK(11), CRY1(6), CRY2(4), DAZAP2(2), DNAJA1(1), EIF4G2(8), ETV6(9), GFRA1(6), GSTM3(4), GSTP1(2), HERPUD1(1), HSPA8(10), IDI1(4), KLF9(3), MYF6(8), NCKAP1(10), NCOA4(12), NR1D2(5), PER1(15), PER2(8), PIGF(4), PPP1R3C(3), PPP2CB(2), PSMA4(2), SF3A3(6), SUMO3(3), TOB1(2), UCP3(1), UGP2(8), VAPA(5), ZFR(13)	12390477	198	49	193	60	49	84	26	10	26	3	0.84	0.94
553	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(5)	721302	12	8	12	4	5	6	0	0	1	0	0.84	0.94
554	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(12), AGMAT(3), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH4A1(2), ALDH9A1(4), AMD1(3), AOC2(6), AOC3(14), ARG1(5), ARG2(6), ASL(4), CKM(3), CKMT1A(5), CKMT1B(2), CKMT2(5), CPS1(24), DAO(5), GATM(8), GLUD1(4), GOT1(6), GOT2(5), MAOA(14), MAOB(7), NOS1(21), NOS3(11), OAT(7), ODC1(3), OTC(8), P4HA1(8), P4HA2(10), P4HA3(5), P4HB(1), RARS(11), SMS(8)	14375611	272	54	264	88	70	117	35	17	29	4	0.85	0.94
555	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(7), ASAH1(9), B4GALT6(5), CERK(8), DEGS1(5), DEGS2(4), ENPP7(3), GAL3ST1(13), GALC(7), GBA(4), GLA(3), GLB1(9), LCT(30), NEU2(5), NEU3(3), PPAP2A(4), PPAP2B(3), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(3), SMPD1(12), SMPD2(5), SMPD3(6), SMPD4(16), SPHK1(2), SPHK2(1), SPTLC1(6), SPTLC2(6), UGCG(5), UGT8(12)	11178269	216	50	213	62	70	88	18	12	28	0	0.85	0.94
556	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(4), CAPN2(6), CAPNS1(3), CAPNS2(6), CXCR3(5), EGF(24), EGFR(20), ITGA1(20), ITGB1(12), MAPK1(2), MAPK3(4), MYL2(1), MYLK(17), PRKACB(2), PRKACG(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(4), PRKAR2B(5), PTK2(11), PXN(6), TLN1(28)	11430892	202	47	195	63	56	84	23	7	30	2	0.85	0.94
557	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(7), APOBEC2(5), APOBEC3A(2), APOBEC3B(8), APOBEC3C(5), APOBEC3F(6), APOBEC3G(4), APOBEC4(4)	2589565	47	24	47	18	12	22	9	1	1	2	0.85	0.95
558	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(2), TGDS(3), UGDH(3), UXS1(5)	1422050	15	13	15	9	5	4	4	1	1	0	0.86	0.95
559	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(15), CALM2(3), CALM3(1), CAPN2(6), CAPNS1(3), CAPNS2(6), EP300(29), HDAC1(4), HDAC2(5), MEF2D(7), NFATC2(15), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), SYT1(4)	8113333	125	37	123	44	29	45	20	7	22	2	0.86	0.95
560	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), HEMK1(2), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), WBSCR22(9)	5012547	101	30	99	23	27	41	10	5	14	4	0.87	0.96
561	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(5), DAB1(7), FYN(7), LRP8(3), RELN(48), VLDLR(6)	4995100	77	31	75	35	22	27	16	3	7	2	0.87	0.96
562	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(6), CYP2E1(5), NR1I3(7), PTGS1(8), PTGS2(7)	1873760	33	18	32	8	9	12	3	2	7	0	0.88	0.96
563	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(6), ALDOB(9), ALDOC(4), FBP1(4), G6PD(3), GPI(9), H6PD(5), PFKM(7), PFKP(11), PGD(4), PGLS(1), PGM1(9), PGM3(6), PRPS1(3), PRPS1L1(5), PRPS2(10), RBKS(1), RPE(3), RPIA(7), TAL1(1), TALDO1(6), TKT(7)	6914987	121	38	116	42	34	53	15	7	10	2	0.88	0.96
564	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), HEMK1(2), LCMT1(4), LCMT2(13), METTL2B(3), METTL6(2), PCYT1A(7), PCYT1B(4), PRMT3(10), PRMT5(11), PRMT6(6), PRMT7(4), PRMT8(9), WBSCR22(9)	4773069	90	29	88	21	24	36	10	5	11	4	0.88	0.96
565	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), CDK5R1(5), DPM2(4), EGR1(8), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(4), NGFR(4), RAF1(7)	2632824	39	23	39	16	12	15	6	3	3	0	0.88	0.96
566	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(6), GLB1(9), GNS(2), GUSB(5), HEXA(3), HEXB(4), IDS(6), LCT(30), NAGLU(3)	4640424	68	31	68	29	20	30	8	5	5	0	0.88	0.96
567	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(8), ADCY9(25), AK1(2), ARF1(4), ARF3(2), ARF4(3), ARF5(5), ARF6(2), ARL4D(1), ATP6V0A1(5), ATP6V0A2(11), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(3), ATP6V0D2(10), ATP6V1A(7), ATP6V1C1(3), ATP6V1C2(9), ATP6V1D(4), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ERO1L(6), GNAS(25), PDIA4(4), PLCG1(12), PLCG2(27), PRKCA(10), SEC61A1(3), SEC61A2(6), SEC61B(1), SEC61G(3), TRIM23(12)	12614420	253	53	247	72	73	112	24	11	31	2	0.88	0.96
568	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(11), CYCS(3), GPD2(5), NDUFA1(1), SDHA(12), SDHB(1), SDHC(6), SDHD(1), UQCRC1(6)	2329533	46	20	46	9	10	24	6	3	3	0	0.89	0.96
569	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(4), CCR3(5), HLA-DRB1(1), IL5(2)	1083387	12	9	12	2	2	4	2	0	4	0	0.89	0.96
570	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(9), CHST12(5), PAPSS1(6), PAPSS2(6), SULT1A1(8), SULT1A2(2), SULT1E1(13), SULT2A1(7), SULT2B1(4), SUOX(4)	3175354	65	26	61	26	19	32	8	2	4	0	0.90	0.97
571	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(8), HLCS(5), SPCS1(1), SPCS3(3)	1059965	17	11	17	13	6	5	4	0	2	0	0.90	0.97
572	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(9), BCAT2(6), IARS(13), IARS2(21), ILVBL(7), LARS(23), LARS2(9), PDHA1(4), PDHA2(10), PDHB(7), VARS(8), VARS2(5)	6538801	122	34	121	25	31	55	15	6	15	0	0.91	0.97
573	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(6), FOS(6), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(4), MYC(7), NFKB1(12), NFKBIA(3), PLCB1(6), PRKCA(10), RAF1(7), RELA(6), TNF(1)	5383714	73	31	73	20	12	27	18	9	7	0	0.91	0.97
574	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(3), CALM3(1), CDKN1A(1), NFATC2(15), NFATC3(12), NFATC4(8), PLCG1(12), PPP3CA(4), PPP3CB(7), PPP3CC(6), PRKCA(10), SP1(6), SP3(12), SYT1(4)	6970913	101	36	97	42	30	36	16	5	14	0	0.91	0.97
575	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), DHFR(3), FPGS(3), GCH1(2), GGH(3), SPR(2)	2019311	28	19	28	10	8	15	2	3	0	0	0.91	0.97
576	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(5), ALDOA(6), ALDOB(9), ALDOC(4), TPI1(1)	1383093	25	14	24	6	7	9	3	2	2	2	0.91	0.97
577	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(27), ACAT1(6), ACAT2(5), ACYP1(2), ADH5(3), AKR1B1(2), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), DLAT(2), DLD(7), GRHPR(4), HAGH(2), LDHA(6), LDHB(2), LDHC(3), LDHD(3), MDH1(2), MDH2(5), ME1(10), ME2(7), ME3(7), PC(8), PCK1(15), PDHA1(4), PDHA2(10), PDHB(7), PKLR(10), PKM2(5)	12406490	200	51	197	71	52	82	25	10	31	0	0.92	0.97
578	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(5), MDH1(2), ME1(10), PC(8), PDHA1(4), SLC25A1(2), SLC25A11(2)	3162448	42	22	42	27	7	21	6	3	5	0	0.92	0.97
579	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB10(3), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMB8(3), PSMB9(1)	3051313	46	22	43	12	9	20	7	2	8	0	0.92	0.97
580	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(13), HSD17B1(3), HSD17B2(3), HSD17B3(6), HSD17B4(10), HSD17B7(4), HSD3B1(1), HSD3B2(5)	2838125	48	23	45	20	13	23	5	1	6	0	0.92	0.97
581	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(7), GOSR1(1), SEC22B(1), SNAP23(2), SNAP25(7), SNAP29(2), STX10(1), STX11(3), STX12(3), STX16(1), STX17(3), STX18(2), STX3(8), STX4(6), STX5(6), STX6(4), STX7(4), STX8(4), TSNARE1(5), USE1(4), VAMP1(1), VAMP4(2), VAMP8(1), VTI1B(9), YKT6(6)	5730264	95	33	92	31	26	40	13	3	11	2	0.92	0.97
582	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(19), BST1(5), CD38(7), ENPP1(11), ENPP3(16), NADK(4), NADSYN1(12), NMNAT1(4), NMNAT2(2), NMNAT3(2), NNMT(7), NNT(9), NT5C(1), NT5C1A(2), NT5C1B(10), NT5C2(7), NT5C3(8), NT5E(6), NT5M(4), NUDT12(2)	7422623	138	39	132	36	35	54	31	12	6	0	0.93	0.97
583	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(5), ACYP1(2), ECHS1(3), EHHADH(9), GCDH(5), HADHA(7), SDHB(1), SDS(3)	2646208	41	21	41	15	9	20	6	4	2	0	0.93	0.97
584	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), AGK(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), AKR1A1(1), AKR1B1(2), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), CEL(6), DAK(8), DGAT2(4), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), GK(14), GK2(20), GLA(3), GLB1(9), GPAM(7), LCT(30), LIPA(6), LIPC(8), LIPF(7), LIPG(6), LPL(11), MGLL(6), PNLIP(3), PNLIPRP1(4), PNLIPRP2(8), PNPLA3(6), PPAP2A(4), PPAP2B(3)	19553307	380	62	370	108	106	157	58	23	34	2	0.93	0.97
585	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(1)	575512	6	5	6	2	3	1	1	0	1	0	0.93	0.97
586	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(19), BAD(2), BAK1(4), BAX(4), BCL10(2), BCL2L1(3), BCL2L11(4), BID(3), CASP8AP2(18), CASP9(3), CES1(12)	3983652	74	27	73	22	18	26	18	4	8	0	0.93	0.97
587	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(11), AASDHPPT(4), AASS(6), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), ATP6V0C(2), BBOX1(4), DLST(10), DOT1L(8), ECHS1(3), EHHADH(9), EHMT2(6), GCDH(5), HADHA(7), PLOD1(4), PLOD2(16), PLOD3(11), SDS(3), SHMT1(6), SHMT2(8), TMLHE(5)	12013813	181	46	178	53	53	61	29	14	20	4	0.93	0.97
588	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(7), AGTR2(8), BDKRB2(9), KNG1(8), NOS3(11), REN(3)	3061590	60	24	57	21	19	28	6	2	5	0	0.94	0.97
589	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH6(9), ADH7(6), ADHFE1(7), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AKR1A1(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), CEL(6), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKZ(9), GK(14), GLA(3), GLB1(9), LCT(30), LIPC(8), LIPF(7), LIPG(6), LPL(11), PNLIP(3), PNLIPRP1(4), PNLIPRP2(8), PPAP2A(4), PPAP2B(3)	15873185	300	56	295	89	83	120	49	17	29	2	0.94	0.97
590	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(12), ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH3B1(5), ALDH3B2(8), ALDH9A1(4), AOC2(6), AOC3(14), ASPA(5), CNDP1(6), DDC(11), HAL(6), HARS(4), HDC(10), HNMT(5), MAOA(14), MAOB(7), PRPS1(3), PRPS2(10)	8577710	162	38	158	55	44	63	21	10	24	0	0.94	0.97
591	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(5), ACOX1(4), ACOX3(8), ELOVL2(5), ELOVL5(4), ELOVL6(3), FADS1(5), FADS2(2), HADHA(7), HSD17B12(4), PECR(5), SCD(9)	3716450	61	24	61	18	16	27	8	4	6	0	0.94	0.97
592	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), RPE(3), UGDH(3), UGP2(8), UGT1A1(6), UGT1A10(8), UGT1A3(4), UGT1A4(4), UGT1A5(7), UGT1A6(5), UGT1A7(9), UGT1A8(4), UGT1A9(4), UGT2A1(9), UGT2A3(5), UGT2B10(14), UGT2B11(22), UGT2B15(9), UGT2B17(4), UGT2B28(14), UGT2B4(10), UGT2B7(10), XYLB(9)	8802370	178	39	169	36	59	64	30	8	17	0	0.94	0.97
593	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(1), CHKA(8), PCYT1A(7), PDHA1(4), PDHA2(10), PEMT(2)	2379723	36	19	36	13	12	11	6	3	4	0	0.94	0.97
594	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(2), TGDS(3), UGDH(3), UGP2(8), UXS1(5)	1796563	23	15	22	10	9	7	5	1	1	0	0.94	0.97
595	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	ASAH1(9), CAMP(1), DAG1(7), ITPKB(6)	1846275	23	18	23	13	8	11	1	0	3	0	0.94	0.97
596	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(20), EGF(24), EGFR(20), RAB5A(2), TF(15), TFRC(6)	4485074	87	28	84	20	25	32	12	5	13	0	0.94	0.97
597	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4)	2683253	36	19	35	16	14	12	2	3	5	0	0.95	0.98
598	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4)	2683253	36	19	35	16	14	12	2	3	5	0	0.95	0.98
599	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(5), B3GALT5(6), FUT1(5), FUT2(3), FUT9(12), GBGT1(6), GLA(3), HEXA(3), HEXB(4), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST8SIA1(4)	3554408	60	25	57	19	16	28	7	3	6	0	0.95	0.98
600	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(9), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH9A1(4), ECHS1(3), EHHADH(9), HADHA(7), SDS(3)	4060849	58	25	57	27	20	21	5	7	5	0	0.95	0.98
601	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(7), EGF(24), EGFR(20), GRB2(3), MET(10), PDGFRA(29), PRKCA(10), SH3GLB1(8), SH3GLB2(3), SH3KBP1(10), SRC(2)	6861212	136	35	131	48	40	51	23	6	14	2	0.96	0.98
602	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(6), PAPSS2(6), SULT1A2(2), SULT1E1(13), SULT2A1(7), SUOX(4)	2179680	39	19	36	14	10	19	6	2	2	0	0.96	0.99
603	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(13), CD2(4), CD33(11), CD5(7), IFNB1(4), IFNG(5), IL10(4), IL12A(7), IL12B(3), IL5(2), ITGAX(9), TLR2(12), TLR4(14), TLR7(15), TLR9(7)	6604765	117	35	114	44	34	47	15	8	11	2	0.97	0.99
604	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(4), COQ5(4), COQ6(3), COQ7(3), NDUFA13(1)	1409144	16	13	16	5	2	9	3	1	1	0	0.97	0.99
605	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ESCO1(11), ESCO2(6), NAT6(2), PNPLA3(6), SH3GLB1(8)	5790253	55	26	55	21	17	24	6	0	8	0	0.98	0.99
606	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(9), HADHA(7), SDS(3)	1618986	23	13	23	14	6	10	3	4	0	0	0.98	1.00
607	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), ABP1(12), AOC2(6), AOC3(14), CES1(12), DDHD1(14), ESCO1(11), ESCO2(6), LIPA(6), NAT6(2), PLA1A(5), PNPLA3(6), PPME1(1), PRDX6(2), SH3GLB1(8)	8989268	110	34	107	41	31	38	21	5	13	2	0.98	1.00
608	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(3), ALPL(3), ALPP(4), ALPPL2(5), ASCC3(25), ATP13A2(6), DDX18(14), DDX19A(1), DDX23(12), DDX4(18), DDX41(2), DDX47(8), DDX50(11), DDX52(7), DDX54(8), DDX55(5), DDX56(6), DHFR(3), DHX58(5), ENTPD7(7), ERCC2(4), ERCC3(11), FPGS(3), GCH1(2), GGH(3), IFIH1(5), NUDT5(1), NUDT8(1), PTS(2), QDPR(1), RAD54B(14), RAD54L(5), RUVBL2(6), SETX(41), SKIV2L2(20), SMARCA2(24), SMARCA5(19), SPR(2)	21254270	317	59	305	94	78	120	58	17	37	7	0.98	1.00
609	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4)	4558447	68	24	66	17	21	25	11	3	8	0	0.99	1.00
610	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(5), PSMA3(5), PSMA4(2), PSMA5(1), PSMA6(2), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(4), PSMB6(3), PSMB7(1), PSMC2(2), PSMC3(1), PSMD1(14), PSMD11(5), PSMD12(4), PSMD13(1), PSMD2(11), PSMD6(2)	5593078	79	28	74	21	18	33	12	2	14	0	0.99	1.00
611	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(1), ECHS1(3), EHHADH(9), HADH(1), HADHA(7), HSD17B10(4), HSD17B4(10), NTAN1(3), SIRT1(8), SIRT2(7), SIRT5(3), VNN2(10)	3895700	66	22	64	21	15	36	9	4	2	0	0.99	1.00
612	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(5), FUT2(3), FUT9(12), GBGT1(6), GLA(3), HEXA(3), HEXB(4), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(4), ST8SIA1(4)	3332855	53	22	52	16	14	24	9	3	3	0	0.99	1.00
613	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(4), AGPAT1(2), AGPAT2(1), AGPAT3(6), AGPAT4(4), AGPAT6(8), CDIPT(1), CDS1(3), CDS2(2), CHAT(1), CHKA(8), DGKA(15), DGKB(17), DGKD(21), DGKE(4), DGKG(13), DGKH(11), DGKI(21), DGKZ(9), ESCO1(11), ESCO2(6), ETNK1(9), ETNK2(3), GNPAT(11), GPAM(7), GPD1(6), GPD1L(3), GPD2(5), LCAT(2), LYPLA1(2), LYPLA2(5), NAT6(2), PCYT1A(7), PCYT1B(4), PEMT(2), PISD(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(2), PLA2G2E(3), PLA2G2F(3), PLA2G3(5), PLA2G4A(11), PLA2G5(2), PLA2G6(6), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(4), PPAP2B(3), PTDSS1(6), PTDSS2(1), SH3GLB1(8)	21566165	330	60	327	117	87	131	48	20	42	2	1.00	1.00
614	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(7), ALDH2(2), ALDH3A1(6), ALDH3A2(2), ALDH7A1(2), ALDH9A1(4), UGDH(3)	2749695	26	16	25	12	11	8	2	2	3	0	1.00	1.00
615	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(6), SRP19(3), SRP54(6), SRP68(6), SRP72(8), SRP9(3), SRPR(8)	2641667	42	18	41	12	11	17	5	3	6	0	1.00	1.00
616	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(7), ACAD9(10), ADH1A(2), ADH1B(6), ADH1C(7), ADH4(5), ADH5(3), ADH6(9), ADH7(6), ADHFE1(7), DHRS1(4), DHRS2(3), DHRS3(2), DHRS7(9), DHRSX(4), ESCO1(11), ESCO2(6), NAT6(2), PNPLA3(6), SH3GLB1(8)	8769627	117	32	116	32	30	47	18	2	18	2	1.00	1.00
