rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(1), ATM(16), BUB1(6), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNH(2), CDAN1(4), CDC14A(4), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC6(2), CDC7(2), CDH1(12), CDK2(2), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(3), DTX4(3), E2F5(1), EP300(10), ESPL1(5), GSK3B(1), HDAC1(2), HDAC2(3), HDAC3(3), HDAC4(6), HDAC5(3), HDAC6(3), HDAC8(3), MAD1L1(4), MAD2L2(1), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), MPEG1(4), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), PLK1(4), PRKDC(18), PTPRA(4), RB1(6), RBL1(3), SKP2(2), SMAD4(5), TBC1D8(4), TGFB1(2), TP53(56), WEE1(1)	22527407	284	93	267	74	45	101	55	16	63	4	<1.00e-15	<1.44e-13
2	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(1), CDKN2A(2), MDM2(2), PIK3CA(23), PIK3R1(5), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), RB1(6), TBX2(3), TP53(56)	4062884	110	76	84	17	25	30	23	3	27	2	<1.00e-15	<1.44e-13
3	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BAK1(1), BID(1), BIRC2(1), BIRC3(3), CASP2(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), FAS(1), JUN(2), MAP2K4(5), MAP3K1(5), MAP3K14(1), MAPK10(3), MDM2(2), NFKB1(4), PARP1(4), PRF1(1), RELA(2), TNF(1), TNFRSF1A(3), TNFSF10(2), TP53(56), TRAF2(2)	7658938	112	74	99	21	22	38	16	5	29	2	<1.00e-15	<1.44e-13
4	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(7), IGF1R(11), POLR2A(6), PPP2CA(1), RB1(6), TEP1(10), TERF1(1), TERT(3), TNKS(5), TP53(56), XRCC5(2)	5739615	110	65	96	33	22	35	21	4	26	2	<1.00e-15	<1.44e-13
5	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(2), AKT2(1), AKT3(3), APAF1(2), ATM(16), BAD(1), BID(1), BIRC2(1), BIRC3(3), CAPN1(1), CAPN2(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CSF2RB(5), CYCS(1), DFFA(2), DFFB(2), ENDOG(1), FAS(1), IKBKB(3), IL1B(1), IL1R1(2), IL1RAP(3), IL3(1), IRAK1(4), IRAK2(4), IRAK3(2), IRAK4(1), MAP3K14(1), MYD88(2), NFKB1(4), NFKB2(2), NTRK1(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RELA(2), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFRSF1A(3), TNFSF10(2), TP53(56), TRAF2(2)	16869188	233	92	206	53	54	79	46	12	38	4	1.78e-15	1.44e-13
6	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(2), ATM(16), BAD(1), BID(1), CASP3(1), CASP7(2), CASP9(1), CYCS(1), EIF2S1(1), PTK2(5), PXN(2), STAT1(3), TLN1(9), TP53(56)	5572700	103	67	89	15	21	32	19	3	24	4	1.78e-15	1.44e-13
7	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), SP1(2), SP3(2), TP53(56), WT1(1)	1415785	63	54	50	9	10	19	9	2	21	2	2.33e-15	1.44e-13
8	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), CDC42(1), DLD(2), DUSP10(2), DUSP8(1), GCK(2), IL1R1(2), JUN(2), MAP2K4(5), MAP2K5(1), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K11(3), MAP3K12(3), MAP3K13(2), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K7(7), MAP3K9(3), MAPK10(3), MAPK7(8), MAPK8(4), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(3), PAPPA(12), SHC1(3), TP53(56), TRAF6(3), ZAK(2)	10285023	165	76	152	37	29	65	22	9	38	2	2.44e-15	1.44e-13
9	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(16), ATR(5), BRCA1(6), BRCA2(14), CHEK1(2), CHEK2(3), FANCC(2), FANCD2(6), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1), TP53(56)	8856603	126	72	112	16	21	36	31	4	30	4	2.66e-15	1.44e-13
10	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(16), ATR(5), BRCA1(6), CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(2), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(3), EP300(10), MDM2(2), PRKDC(18), RPS6KA1(2), TP53(56), WEE1(1), YWHAQ(2)	8663886	135	76	121	19	20	43	26	4	38	4	3.22e-15	1.44e-13
11	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(16), CDK2(2), CDKN1A(1), MDM2(2), PCNA(2), RB1(6), TIMP3(2), TP53(56)	3699794	89	65	74	8	13	25	18	4	25	4	3.22e-15	1.44e-13
12	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(16), CDC25A(2), CDC25B(4), CDC25C(2), CDK2(2), CHEK1(2), RB1(6), TP53(56), WEE1(1)	3556420	91	65	76	5	14	25	19	3	26	4	3.22e-15	1.44e-13
13	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(4), LIN7A(6), NFKB1(4), RB1(6), RELA(2), TNF(1), TNFRSF1A(3), TP53(56), USH1C(1), WT1(1)	3793027	93	63	78	15	14	30	17	3	27	2	3.55e-15	1.44e-13
14	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(1), ATM(16), ATR(5), CCNA1(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), GSK3B(1), HDAC1(2), RB1(6), SKP2(2), TGFB1(2), TGFB2(4), TGFB3(3), TP53(56)	6037269	111	69	96	21	20	32	24	4	27	4	3.66e-15	1.44e-13
15	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(8), AKT1(2), ATM(16), CDKN1A(1), CPB2(4), HIF1A(1), IGFBP3(4), MAPK8(4), MDM2(2), NFKBIB(3), NQO1(3), TP53(56)	4241104	104	71	90	16	20	30	20	2	28	4	3.77e-15	1.44e-13
16	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(2), ATM(16), ATR(5), BAI1(6), BID(1), CASP3(1), CASP8(3), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNG2(1), CD82(1), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(3), CYCS(1), DDB2(2), EI24(1), FAS(1), GTSE1(2), IGF1(2), IGFBP3(4), LRDD(4), MDM2(2), PERP(1), PPM1D(3), PTEN(5), RFWD2(4), RPRM(3), RRM2(1), RRM2B(1), SERPINB5(3), SERPINE1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(4), THBS1(5), TNFRSF10B(1), TP53(56), TP73(4), TSC2(3), ZMAT3(1)	13299202	179	84	165	40	40	60	30	9	36	4	4.00e-15	1.44e-13
17	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BAD(1), BAK1(1), BCL2L11(1), BID(1), BIRC2(1), BIRC3(3), BIRC5(1), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), FAS(1), HELLS(3), IKBKB(3), IRF2(8), IRF3(3), IRF4(1), IRF5(1), IRF6(2), IRF7(1), JUN(2), LTA(1), MAP2K4(5), MAP3K1(5), MAPK10(3), MDM2(2), NFKB1(4), NFKBIB(3), PLEKHG5(5), PRF1(1), RELA(2), TNF(1), TNFRSF10B(1), TNFRSF1A(3), TNFRSF21(3), TNFRSF25(2), TNFSF10(2), TP53(56), TP73(4), TRAF2(2), TRAF3(2)	11722221	163	81	150	32	31	56	26	12	36	2	4.11e-15	1.44e-13
18	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(1), NFKB1(4), RELA(2), TP53(56)	2047003	67	57	54	5	10	21	9	3	22	2	4.22e-15	1.44e-13
19	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(16), ATR(5), CDC25C(2), CHEK1(2), CHEK2(3), TP53(56)	3208226	84	65	70	7	13	26	15	2	24	4	4.44e-15	1.44e-13
20	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(1), ATM(16), BRCA1(6), CDKN1A(1), CHEK1(2), CHEK2(3), JUN(2), MAPK8(4), MDM2(2), MRE11A(2), NFKB1(4), RAD50(6), RAD51(1), RBBP8(3), RELA(2), TP53(56), TP73(4)	6053495	115	72	101	13	21	36	20	4	30	4	4.88e-15	1.50e-13
21	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(2), CDK2(2), CDKN1A(1), CDKN2A(2), CFL1(1), MDM2(2), NXT1(2), PRB1(1), TP53(56)	1630580	69	58	56	6	11	23	7	4	22	2	5.55e-15	1.63e-13
22	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(11), DAXX(3), PAX3(3), PML(2), RARA(1), RB1(6), SIRT1(3), SP100(3), TNF(1), TNFRSF1A(3), TP53(56)	3911663	92	68	78	19	18	29	15	3	25	2	6.55e-15	1.83e-13
23	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(16), CCNA1(2), CCNB1(1), CCND2(1), CCND3(2), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(2), CDKN2D(1), CREB3(3), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F5(1), GBA2(2), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), MNAT1(2), NACA(1), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), POLA2(1), POLE2(1), PRIM1(1), RB1(6), RBL1(3), RPA1(1), RPA2(1), RPA3(1), TFDP2(2), TNXB(20), TP53(56), WEE1(1)	15636943	187	79	172	42	37	66	36	8	36	4	2.69e-14	7.20e-13
24	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(1), AKT3(3), ARRB1(3), ARRB2(2), BDNF(1), BRAF(5), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1F(2), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(9), CACNA2D1(5), CACNA2D2(5), CACNA2D3(5), CACNA2D4(8), CACNB1(1), CACNB2(7), CACNB4(3), CACNG3(2), CACNG4(3), CACNG5(2), CACNG6(1), CACNG7(2), CASP3(1), CD14(1), CDC25B(4), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(2), DUSP16(3), DUSP2(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(4), EGFR(7), ELK1(2), ELK4(3), FAS(1), FGF1(2), FGF10(4), FGF11(1), FGF12(3), FGF13(3), FGF14(3), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF22(4), FGF23(1), FGF5(1), FGF6(3), FGF7(1), FGF9(4), FGFR1(6), FGFR2(5), FGFR3(1), FGFR4(5), FLNA(5), FLNB(3), FLNC(18), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(2), JUN(2), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K12(3), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K6(5), MAP3K7(7), MAP4K1(2), MAP4K2(3), MAP4K3(2), MAP4K4(4), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MAPKAPK3(3), MAPKAPK5(1), MAPT(4), MEF2C(1), MKNK1(1), MOS(3), NF1(12), NFATC2(5), NFATC4(9), NFKB1(4), NFKB2(2), NLK(3), NR4A1(1), NTF3(2), NTRK1(3), NTRK2(4), PAK1(2), PAK2(3), PDGFA(1), PDGFB(3), PDGFRA(2), PDGFRB(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PPM1A(2), PPM1B(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PTPN7(2), PTPRR(4), RAC2(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(6), RASA1(10), RASA2(6), RASGRF1(4), RASGRF2(7), RASGRP1(3), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KA6(6), RRAS(1), RRAS2(1), SOS1(3), SOS2(4), SRF(1), STK3(3), STK4(2), STMN1(1), TAOK1(5), TAOK2(6), TAOK3(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TNF(1), TNFRSF1A(3), TP53(56), TRAF2(2), TRAF6(3), ZAK(2)	59524017	699	110	675	202	163	263	115	53	99	6	3.09e-14	7.92e-13
25	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(1), ANAPC1(13), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(16), ATR(5), BUB1(6), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNH(2), CDC14A(4), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(2), CDC26(1), CDC27(1), CDC6(2), CDC7(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CDKN2D(1), CHEK1(2), CHEK2(3), CREBBP(11), CUL1(5), DBF4(4), EP300(10), ESPL1(5), FZR1(3), GSK3B(1), HDAC1(2), HDAC2(3), MAD1L1(4), MAD2L2(1), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), PKMYT1(1), PLK1(4), PRKDC(18), RB1(6), RBL1(3), RBL2(1), SKP2(2), SMAD2(7), SMAD3(2), SMAD4(5), SMC1A(3), SMC1B(2), TGFB1(2), TGFB2(4), TGFB3(3), TP53(56), WEE1(1), YWHAG(1), YWHAQ(2), YWHAZ(1)	27786227	321	95	297	97	53	106	70	19	69	4	4.93e-14	1.21e-12
26	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(18), AXIN1(8), CD14(1), CTNNB1(8), DVL1(3), FZD1(7), GJA1(7), GNAI1(1), GSK3B(1), IRAK1(4), LEF1(3), LY96(1), MYD88(2), NFKB1(4), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), RELA(2), TIRAP(1), TLR4(9), TOLLIP(1), WNT1(3)	6144600	116	65	100	32	29	29	34	4	16	4	5.44e-14	1.29e-12
27	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRB1(2), ADRB2(2), ADRB3(1), ANXA6(2), ARRB1(3), ARRB2(2), ATP1A4(5), ATP1B3(1), ATP2A2(4), ATP2A3(3), ATP2B1(8), ATP2B2(7), ATP2B3(7), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1S(9), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CASQ1(2), CASQ2(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), GJA1(7), GJA4(4), GJB3(2), GJB6(2), GNA11(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAZ(5), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNG12(1), GNG7(2), GNGT1(2), GRK4(1), GRK5(1), ITPR1(13), ITPR2(12), ITPR3(10), KCNB1(3), KCNJ3(3), MIB1(1), NME7(1), PLCB3(6), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), PRKD1(5), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS2(1), RGS20(2), RGS3(7), RGS5(1), RGS6(6), RGS7(1), RGS9(2), RYR1(24), RYR2(31), RYR3(27), SLC8A1(3), SLC8A3(5), USP5(3), YWHAQ(2)	38763648	451	94	446	177	124	148	91	35	53	0	8.76e-13	2.00e-11
28	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(18), APC2(4), AXIN1(8), AXIN2(1), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CCND2(1), CCND3(2), CHD8(5), CREBBP(11), CSNK1A1L(1), CSNK1E(5), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(2), CTNNB1(8), CTNNBIP1(1), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(4), DKK1(4), DKK2(2), DKK4(2), DVL1(3), DVL2(2), DVL3(3), EP300(10), FBXW11(4), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GSK3B(1), JUN(2), LEF1(3), LRP5(8), LRP6(3), MAP3K7(7), MAPK10(3), MAPK8(4), MAPK9(1), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NKD1(4), NKD2(1), NLK(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PORCN(3), PPARD(4), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRICKLE1(6), PRICKLE2(10), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PSEN1(1), RAC2(1), RHOA(4), ROCK1(5), ROCK2(2), RUVBL1(3), SENP2(2), SFRP1(2), SFRP2(1), SFRP4(1), SFRP5(1), SIAH1(1), SMAD2(7), SMAD3(2), SMAD4(5), SOX17(4), TBL1X(2), TBL1XR1(2), TCF7(1), TCF7L1(3), TCF7L2(3), TP53(56), VANGL1(1), WIF1(1), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2)	33302668	432	99	409	134	98	154	75	23	76	6	1.85e-12	4.07e-11
29	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BFAR(1), BTK(1), CAD(4), CASP10(2), CASP3(1), CASP8(3), CASP8AP2(4), DAXX(3), DEDD(1), DEDD2(1), DFFA(2), DIABLO(1), EGFR(7), EPHB2(10), FAF1(3), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(8), MAP3K1(5), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MET(3), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), NR0B2(1), PFN2(2), PTPN13(10), RALBP1(7), ROCK1(5), SMPD1(3), TP53(56), TPX2(4), TRAF2(2), TUFM(3)	15170778	200	77	184	61	39	69	31	13	46	2	1.45e-11	3.07e-10
30	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(12), CREBBP(11), CSNK2A1(4), CSNK2A2(1), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTNND1(5), EGFR(7), EP300(10), ERBB2(4), FARP2(2), FER(6), FGFR1(6), FYN(3), IGF1R(11), INSR(7), IQGAP1(3), LEF1(3), LMO7(4), MAP3K7(7), MAPK1(2), MAPK3(1), MET(3), MLLT4(12), NLK(3), PARD3(6), PTPRB(10), PTPRF(6), PTPRJ(12), PTPRM(15), PVRL1(2), PVRL2(1), PVRL3(3), PVRL4(4), RAC2(1), RHOA(4), SMAD2(7), SMAD3(2), SMAD4(5), SNAI1(1), SNAI2(4), SORBS1(5), SSX2IP(3), TCF7(1), TCF7L1(3), TCF7L2(3), TGFBR1(1), TGFBR2(4), TJP1(4), VCL(2), WASF1(3), WASF2(2), WASF3(3), WASL(1), YES1(2)	24108245	298	77	292	93	79	102	43	23	51	0	4.48e-09	9.20e-08
31	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(6), CADM1(8), CADM3(4), CD2(2), CD226(2), CD274(1), CD276(2), CD34(2), CD4(3), CD40(1), CD40LG(3), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(1), CDH1(12), CDH2(7), CDH3(5), CDH4(8), CDH5(2), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CNTN1(9), CNTN2(3), CNTNAP1(10), CNTNAP2(10), CTLA4(2), ESAM(4), GLG1(4), HLA-A(8), HLA-B(10), HLA-C(4), HLA-DMA(1), HLA-DMB(2), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DRA(2), HLA-DRB1(1), HLA-E(3), HLA-F(4), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(7), ITGA6(2), ITGA8(3), ITGA9(6), ITGAL(6), ITGAM(4), ITGAV(2), ITGB1(2), ITGB2(5), ITGB7(2), ITGB8(6), JAM3(2), L1CAM(3), MADCAM1(2), MAG(4), MPZ(2), NCAM2(6), NEGR1(3), NEO1(6), NFASC(8), NLGN1(6), NLGN2(4), NLGN3(4), NRCAM(4), NRXN1(11), NRXN2(12), NRXN3(10), PDCD1LG2(1), PTPRC(13), PTPRF(6), PTPRM(15), PVR(2), PVRL1(2), PVRL2(1), PVRL3(3), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(2), SELL(3), SELP(2), SELPLG(5), SIGLEC1(8), VCAM1(4), VCAN(19)	30468970	413	94	410	155	88	162	87	33	41	2	1.15e-08	2.29e-07
32	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(3), ARHGEF2(2), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(8), CTTN(1), FYN(3), HCLS1(1), ITGB1(2), KRT18(3), LY96(1), NCK1(2), NCK2(2), NCL(3), RHOA(4), ROCK1(5), ROCK2(2), TLR4(9), TLR5(1), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	10705037	103	55	99	49	23	36	26	9	9	0	1.54e-08	2.88e-07
33	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(3), ARHGEF2(2), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(8), CTTN(1), FYN(3), HCLS1(1), ITGB1(2), KRT18(3), LY96(1), NCK1(2), NCK2(2), NCL(3), RHOA(4), ROCK1(5), ROCK2(2), TLR4(9), TLR5(1), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	10705037	103	55	99	49	23	36	26	9	9	0	1.54e-08	2.88e-07
34	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(18), CDH1(12), CREBBP(11), EP300(10), MAP2K1(3), MAP3K7(7), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4)	5153750	79	42	78	20	19	24	14	3	17	2	2.10e-08	3.80e-07
35	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(8), ITGB1(2), KLRC1(1), KLRC2(1), KLRD1(1), MAP2K1(3), MAPK3(1), PAK1(2), PIK3CA(23), PIK3R1(5), PTK2B(8), SYK(1), VAV1(2)	3753526	60	43	48	16	16	10	20	4	10	0	4.22e-08	7.43e-07
36	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(5), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ARRB1(3), ARRB2(2), ATF5(3), ATP2A2(4), ATP2A3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CNN1(1), CORIN(4), CREB3(3), CRHR1(1), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(2), GJA1(7), GNAQ(1), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNG12(1), GNG7(2), GNGT1(2), GRK4(1), GRK5(1), GUCA2A(1), GUCY1A3(7), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), IL6(1), ITPR1(13), ITPR2(12), ITPR3(10), JUN(2), MIB1(1), MYL2(1), MYL4(1), MYLK2(2), NFKB1(4), NOS1(15), NOS3(2), OXT(2), OXTR(3), PDE4B(4), PLCB3(6), PLCG1(9), PLCG2(5), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCH(2), PRKCQ(1), PRKD1(5), RAMP2(1), RAMP3(3), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS2(1), RGS20(2), RGS3(7), RGS5(1), RGS6(6), RGS7(1), RGS9(2), RYR1(24), RYR2(31), RYR3(27), SLC8A1(3), SP1(2), TNXB(20), USP5(3), YWHAQ(2)	35609952	401	88	397	159	121	126	78	34	42	0	5.46e-08	9.35e-07
37	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(5), CPEB1(2), EGFR(7), ERBB2(4), ERBB4(12), ETS1(3), ETS2(1), ETV6(3), ETV7(1), FMN2(14), GRB2(1), KRAS(7), MAP2K1(3), MAPK1(2), MAPK3(1), NOTCH1(9), NOTCH2(9), NOTCH3(8), NOTCH4(6), PIWIL1(2), PIWIL2(6), PIWIL3(2), PIWIL4(1), RAF1(6), SOS1(3), SOS2(4), SPIRE1(2)	10776857	124	61	116	54	28	44	26	12	14	0	1.78e-07	2.96e-06
38	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(5), ACTN2(11), ACTN3(1), ACTN4(1), DES(1), DMD(16), FAM48A(3), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH3(13), MYH6(7), MYH7(11), MYH8(7), MYL1(1), MYL2(1), MYL4(1), MYOM1(1), NEB(24), TCAP(1), TMOD1(3), TNNC2(1), TNNI2(3), TNNI3(1), TNNT1(2), TNNT2(1), TPM4(2), TTN(212), VIM(1)	28074172	340	85	337	105	75	103	100	35	23	4	2.22e-07	3.60e-06
39	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(1), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(3), BIRC2(1), BIRC3(3), BRAF(5), CAPN2(3), CAV1(2), CCND2(1), CCND3(2), CDC42(1), CHAD(3), COL11A1(12), COL11A2(5), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), COMP(1), CRK(1), CTNNB1(8), DIAPH1(3), DOCK1(10), EGF(4), EGFR(7), ELK1(2), ERBB2(4), FARP2(2), FLNA(5), FLNB(3), FLNC(18), FLT1(5), FN1(15), FYN(3), GRB2(1), GRLF1(8), GSK3B(1), HGF(7), IBSP(1), IGF1(2), IGF1R(11), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAV(2), ITGB1(2), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), JUN(2), KDR(7), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), MAP2K1(3), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), MET(3), MYL2(1), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARVA(1), PARVB(3), PARVG(2), PDGFA(1), PDGFB(3), PDGFC(2), PDGFD(3), PDGFRA(2), PDGFRB(5), PDPK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP5K1C(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(5), PTK2(5), PXN(2), RAC2(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(15), RHOA(4), ROCK1(5), ROCK2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TLN1(9), TLN2(11), TNC(11), TNN(10), TNR(9), TNXB(20), VASP(2), VAV1(2), VAV2(5), VAV3(6), VCL(2), VEGFC(3), VTN(4), VWF(8), ZYX(2)	75964014	809	108	790	354	230	273	147	64	93	2	2.50e-07	3.95e-06
40	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD3G(2), CD80(1), CD86(2), CTLA4(2), GRB2(1), HLA-DRA(2), HLA-DRB1(1), ICOS(1), IL2(1), ITK(2), LCK(1), PIK3CA(23), PIK3R1(5), PTPN11(3)	2554132	48	36	35	13	15	7	16	4	6	0	5.51e-07	8.41e-06
41	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(23), PIK3R1(5), PLCB1(8), PLCG1(9), VAV1(2)	2576476	49	35	36	13	16	10	16	1	6	0	5.60e-07	8.41e-06
42	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), APC(18), APC2(4), ARAF(6), ARHGEF1(1), ARHGEF12(5), ARHGEF4(4), ARHGEF6(8), ARHGEF7(7), ARPC1A(1), ARPC1B(1), ARPC4(1), BCAR1(3), BDKRB1(1), BDKRB2(2), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CRK(1), CSK(2), CYFIP1(2), CYFIP2(8), DIAPH1(3), DIAPH2(3), DIAPH3(10), DOCK1(10), EGF(4), EGFR(7), F2(4), F2R(2), FGD1(4), FGD3(5), FGF1(2), FGF10(4), FGF11(1), FGF12(3), FGF13(3), FGF14(3), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF22(4), FGF23(1), FGF5(1), FGF6(3), FGF7(1), FGF9(4), FGFR1(6), FGFR2(5), FGFR3(1), FGFR4(5), FN1(15), GIT1(2), GNA12(1), GNG12(1), GRLF1(8), GSN(4), IQGAP1(3), IQGAP2(5), IQGAP3(5), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAD(3), ITGAE(4), ITGAL(6), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(2), ITGB2(5), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), KRAS(7), LIMK1(2), LIMK2(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(13), MYH14(8), MYH9(13), MYL2(1), MYLK(7), MYLK2(2), NCKAP1(4), NCKAP1L(7), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(2), PDGFRB(5), PFN2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(2), PTK2(5), PXN(2), RAC2(1), RAF1(6), RDX(1), RHOA(4), ROCK1(5), ROCK2(2), RRAS(1), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(3), SOS2(4), SSH1(4), SSH2(10), SSH3(2), TIAM1(11), TIAM2(15), TMSL3(1), VAV1(2), VAV2(5), VAV3(6), VCL(2), WASF1(3), WASF2(2), WASL(1)	56845530	662	105	637	244	179	217	132	44	88	2	6.43e-07	9.43e-06
43	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(4), GH1(1), GHR(5), IGF1(2), IGF1R(11), PIK3CA(23), PIK3R1(5), SHC1(3), SOD2(1)	2684206	57	38	45	10	16	14	19	2	6	0	8.17e-07	0.000012
44	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(12), GNB1(1), GNGT1(2), NFKB1(4), NOS3(2), NR3C1(3), PIK3CA(23), PIK3R1(5), RELA(2)	3689420	65	41	52	13	16	19	16	5	9	0	2.40e-06	0.000034
45	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), CACNA1C(17), CACNA1D(12), CACNA1F(2), CACNA1S(9), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CDC42(1), EGFR(7), ELK1(2), FSHB(1), GNA11(1), GNAQ(1), GNAS(12), GNRH2(1), GNRHR(2), GRB2(1), ITPR1(13), ITPR2(12), ITPR3(10), JUN(2), KRAS(7), LHB(1), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK9(1), MMP2(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLD1(6), PLD2(10), PRKACA(1), PRKACB(2), PRKACG(2), PRKCD(2), PRKX(1), PTK2B(8), RAF1(6), SOS1(3), SOS2(4)	26309794	317	77	313	103	74	126	60	21	36	0	3.03e-06	0.000042
46	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(1), IGF1(2), IGF1R(11), INPPL1(11), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), PTEN(5), RPS6(1), RPS6KB1(2)	3997315	74	43	61	15	22	18	21	2	11	0	3.55e-06	0.000048
47	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(3), ACVR1B(4), ACVR2A(16), ACVR2B(3), AMH(1), AMHR2(3), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(9), CCL18(1), CCL20(1), CCL23(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CCR9(1), CD27(2), CD40(1), CD40LG(3), CLCF1(1), CNTF(2), CNTFR(2), CSF1R(7), CSF2RB(5), CSF3(1), CSF3R(3), CX3CL1(3), CX3CR1(4), CXCL16(2), CXCL2(1), CXCL9(1), CXCR4(2), EDA(1), EGF(4), EGFR(7), EPOR(2), FAS(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(2), GHR(5), HGF(7), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(1), IL10RB(1), IL11(1), IL11RA(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL13(1), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(6), IL17RB(1), IL18R1(2), IL18RAP(1), IL1B(1), IL1R1(2), IL1RAP(3), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23R(5), IL25(2), IL26(1), IL28A(1), IL28B(1), IL2RA(1), IL2RG(2), IL3(1), IL6(1), IL6ST(1), IL7R(3), IL8(1), INHBA(4), INHBB(7), INHBC(1), INHBE(1), KDR(7), KIT(5), KITLG(3), LEPR(7), LIF(2), LIFR(6), LTA(1), LTBR(2), MET(3), NGFR(2), OSM(2), OSMR(3), PDGFB(3), PDGFC(2), PDGFRA(2), PDGFRB(5), PF4V1(1), PRL(1), PRLR(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(2), TNFRSF1A(3), TNFRSF21(3), TNFRSF25(2), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF11(1), TNFSF18(2), TNFSF8(1), TPO(12), TSLP(3), VEGFC(3), XCR1(3)	35324534	377	84	360	143	86	118	86	30	55	2	4.62e-06	0.000061
48	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(6), BRAF(5), CACNA1A(9), CRHR1(1), GNA11(1), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GNAZ(5), GRIA1(6), GRIA2(8), GRIA3(5), GRID2(7), GRM1(11), GRM5(11), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), IGF1(2), IGF1R(11), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), LYN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(15), NOS3(2), NPR1(6), NPR2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PRKCG(4), PRKG1(4), PRKG2(6), RAF1(6), RYR1(24)	22640856	305	76	301	97	69	128	63	20	25	0	5.76e-06	0.000074
49	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(18), AXIN1(8), BMP10(2), BMP2(2), BMP4(5), BMP5(5), BMP7(2), BMPR1A(1), BMPR2(9), CHRD(1), CTNNB1(8), DVL1(3), FZD1(7), GATA4(2), GSK3B(1), MAP3K7(7), MEF2C(1), MYL2(1), NKX2-5(2), NPPB(1), RFC1(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TGFBR3(1), WNT1(3)	7311941	108	49	104	36	30	27	24	5	16	6	8.38e-06	0.00011
50	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY7(8), ADCY8(8), ADCY9(4), ADORA2B(1), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(3), ATP2B1(8), ATP2B2(7), ATP2B3(7), ATP2B4(1), AVPR1A(5), AVPR1B(1), BDKRB1(1), BDKRB2(2), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1F(2), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(9), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CCKAR(2), CCKBR(3), CD38(2), CHRM1(1), CHRM2(6), CHRM3(4), CHRM5(3), CHRNA7(1), CYSLTR1(2), DRD1(2), EDNRA(2), EDNRB(10), EGFR(7), ERBB2(4), ERBB3(12), ERBB4(12), F2R(2), GNA11(1), GNA14(1), GNA15(2), GNAQ(1), GNAS(12), GRIN1(3), GRIN2A(7), GRIN2C(2), GRIN2D(1), GRM1(11), GRM5(11), GRPR(3), HRH1(3), HRH2(2), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), LHCGR(5), LTB4R2(2), MYLK(7), MYLK2(2), NOS1(15), NOS3(2), NTSR1(1), OXTR(3), P2RX3(1), P2RX4(1), P2RX5(2), PDE1A(2), PDE1B(1), PDE1C(2), PDGFRA(2), PDGFRB(5), PHKA1(4), PHKA2(4), PHKB(3), PHKG1(2), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(24), RYR2(31), RYR3(27), SLC25A4(1), SLC25A5(2), SLC8A1(3), SLC8A2(3), SLC8A3(5), SPHK1(4), TACR1(2), TACR2(1), TACR3(4), TBXA2R(6), TNNC1(2), TNNC2(1), TRHR(5), TRPC1(2), VDAC1(1)	55848562	664	99	653	234	182	233	128	50	67	4	0.000011	0.00013
51	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), DOCK1(10), ELK1(2), GRB2(1), HGF(7), ITGA1(4), ITGB1(2), JUN(2), MAP2K1(3), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(4), MET(3), PAK1(2), PIK3CA(23), PIK3R1(5), PTEN(5), PTK2(5), PTK2B(8), PTPN11(3), PXN(2), RAF1(6), RAP1A(1), RAP1B(2), RASA1(10), SOS1(3), STAT3(4)	9040276	125	56	110	39	29	38	31	8	17	2	0.000014	0.00016
52	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(2), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(1), CHRNA1(3), FLT1(5), FLT4(6), KDR(7), NOS3(2), PDE2A(6), PDE3A(3), PDE3B(9), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKG1(4), PRKG2(6), RYR2(31), SLC7A1(1)	8335775	107	59	107	37	30	36	27	11	3	0	0.000016	0.00019
53	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADRB1(2), DRD1(2), DRD2(5), EGF(4), EGFR(7), GJA1(7), GJD2(1), GNA11(1), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GRB2(1), GRM1(11), GRM5(11), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), HTR2A(1), HTR2B(4), HTR2C(2), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K5(1), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(8), NPR1(6), NPR2(2), PDGFA(1), PDGFB(3), PDGFC(2), PDGFD(3), PDGFRA(2), PDGFRB(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKG1(4), PRKG2(6), PRKX(1), RAF1(6), SOS1(3), SOS2(4), TJP1(4), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2)	26936490	331	80	326	129	85	124	75	23	24	0	0.000023	0.00027
54	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(18), AXIN1(8), CREBBP(11), CTNNB1(8), DVL1(3), EP300(10), FZD1(7), GSK3B(1), HDAC1(2), LDB1(4), LEF1(3), PITX2(2), TRRAP(19), WNT1(3)	6582968	99	49	97	41	34	27	11	4	19	4	0.000023	0.00027
55	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(5), CD36(1), CD44(3), CHAD(3), COL11A1(12), COL11A2(5), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), DAG1(7), FN1(15), FNDC1(7), FNDC3A(6), FNDC4(1), GP1BA(1), GP5(2), GP6(1), HMMR(2), HSPG2(14), IBSP(1), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAV(2), ITGB1(2), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), RELN(15), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SV2A(4), SV2B(1), SV2C(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNC(11), TNN(10), TNR(9), TNXB(20), VTN(4), VWF(8)	46546010	478	87	476	221	137	173	70	35	63	0	0.000032	0.00036
56	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(9), AKT1(2), BAD(1), CSF2RB(5), IGF1(2), IGF1R(11), IL3(1), KIT(5), KITLG(3), PIK3CA(23), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	4200273	79	43	67	24	25	23	22	4	5	0	0.000051	0.00056
57	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(7), EIF4G2(1), EIF4G3(5), GHR(5), IRS1(5), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(2), PDPK1(1), PIK3CA(23), PIK3R1(5), PTEN(5), RPS6KB1(2)	5661145	75	45	63	28	19	19	24	5	8	0	0.000066	0.00071
58	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(2), GRB2(1), INSR(7), IRS1(5), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PTPN11(3), RAF1(6), RASA1(10), SHC1(3), SLC2A4(1), SOS1(3), SRF(1)	5142046	84	44	71	16	22	24	20	5	11	2	0.000078	0.00082
59	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(5), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(2), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(4), CCKAR(2), CCKBR(3), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CNR1(4), CRHR1(1), CRHR2(3), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(5), DRD3(7), DRD5(8), EDNRA(2), EDNRB(10), F2(4), F2R(2), F2RL1(3), FPR1(1), FSHB(1), FSHR(11), GABBR1(7), GABBR2(5), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GABRB1(1), GABRB2(3), GABRB3(5), GABRE(4), GABRG1(1), GABRG2(8), GABRG3(1), GABRP(4), GABRQ(6), GABRR1(6), GABRR2(5), GALR1(2), GALR3(1), GH1(1), GH2(2), GHR(5), GHSR(4), GLP1R(1), GLP2R(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(2), GPR35(3), GPR50(3), GPR83(4), GRIA1(6), GRIA2(8), GRIA3(5), GRIA4(3), GRID1(14), GRID2(7), GRIK1(5), GRIK2(11), GRIK3(7), GRIK4(6), GRIK5(5), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), GRIN3A(5), GRIN3B(2), GRM1(11), GRM2(8), GRM3(3), GRM4(3), GRM5(11), GRM6(4), GRM7(6), GRM8(8), GRPR(3), GZMA(1), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), LEPR(7), LHB(1), LHCGR(5), LTB4R(2), LTB4R2(2), MAS1(1), MC2R(1), MC3R(3), MC4R(2), MC5R(6), MCHR1(2), MCHR2(2), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(1), NPBWR1(6), NPFFR1(1), NPFFR2(2), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(3), OXTR(3), P2RX3(1), P2RX4(1), P2RX5(2), P2RY1(3), P2RY10(1), P2RY13(4), P2RY14(2), P2RY4(2), PARD3(6), PPYR1(5), PRL(1), PRLHR(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(2), RXFP1(4), RXFP2(5), SCTR(2), SSTR1(4), SSTR3(3), SSTR4(6), SSTR5(1), TAAR1(3), TAAR2(1), TAAR5(1), TAAR6(2), TACR1(2), TACR2(1), TACR3(4), TBXA2R(6), THRA(1), THRB(4), TRHR(5), TRPV1(5), TSHB(1), TSHR(5), VIPR1(2)	45330257	650	104	642	177	183	212	151	52	52	0	0.000079	0.00082
60	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(1), AKT3(3), BPNT1(2), GRB2(1), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(23), PIK3CD(6), PTEN(5), PTK2B(8), RBL2(1), SHC1(3), SOS1(3)	4116882	62	40	50	21	17	21	17	2	5	0	0.000080	0.00082
61	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(18), AXIN1(8), BTRC(2), CREBBP(11), CSNK2A1(4), CTBP1(2), CTNNB1(8), DVL1(3), FZD1(7), GSK3B(1), HDAC1(2), MAP3K7(7), NLK(3), PPARD(4), PPP2CA(1), TLE1(2), WIF1(1), WNT1(3)	5884585	87	44	85	33	23	30	9	4	17	4	0.000092	0.00093
62	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(18), AXIN1(8), BTRC(2), CTNNB1(8), DLL1(1), DVL1(3), FZD1(7), GSK3B(1), NOTCH1(9), PSEN1(1), WNT1(3)	4339923	62	38	60	32	15	23	7	3	10	4	0.00012	0.0012
63	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(1), AKT3(3), ANKRD6(3), APC(18), AXIN1(8), AXIN2(1), CTNNB1(8), DACT1(2), DKK1(4), DKK2(2), DKK3(1), DKK4(2), DVL1(3), GSK3B(1), LRP1(14), MVP(4), NKD1(4), NKD2(1), PIN1(1), PSEN1(1), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(1)	8172850	94	51	92	30	20	35	16	9	10	4	0.00012	0.0012
64	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(18), AXIN1(8), CCND2(1), CCND3(2), CSNK1E(5), CTNNB1(8), DVL1(3), DVL2(2), DVL3(3), FBXW2(2), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GSK3B(1), JUN(2), LDLR(3), MAPK10(3), MAPK9(1), PAFAH1B1(3), PLAU(1), PPP2R5C(1), PPP2R5E(2), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PRKD1(5), RHOA(4), SFRP4(1), TCF7(1), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1)	12201686	150	59	145	67	37	50	26	9	24	4	0.00013	0.0012
65	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(9), ARHGEF1(1), F2(4), F2R(2), GNA12(1), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(2), MAP3K7(7), PIK3CA(23), PIK3R1(5), PLCB1(8), PPP1R12B(2), PTK2B(8), ROCK1(5)	5254830	80	43	68	28	24	19	24	2	11	0	0.00014	0.0013
66	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(4), EGFR(7), ELK1(2), GRB2(1), JAK1(5), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1), STAT1(3), STAT3(4)	7545356	110	53	96	26	31	35	20	5	15	4	0.00014	0.0013
67	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(11), IRS1(5), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PTPN11(3), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1)	4984574	89	43	76	15	25	27	22	4	9	2	0.00015	0.0014
68	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(16), BMPR1B(2), CCND2(1), DMC1(1), EGR1(3), ESR2(5), FSHR(11), GJA4(4), INHA(2), LHCGR(5), MLH1(2), MSH5(3), NCOR1(10), NR5A1(4), NRIP1(7), PGR(5), PRLR(2), PTGER2(2), SMPD1(3), VDR(5), ZP2(3)	7088235	96	51	93	24	21	31	27	4	11	2	0.00016	0.0015
69	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(9), AKT1(2), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(2), ITGAV(2), ITGB3(5), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLCB1(8), PTK2(5), SMPD1(3), SPHK1(4)	5493565	77	46	65	32	22	18	23	4	10	0	0.00017	0.0015
70	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(9), ADCY8(8), ARAF(6), BRAF(5), CACNA1C(17), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CREBBP(11), EP300(10), GNAQ(1), GRIA1(6), GRIA2(8), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), GRM1(11), GRM5(11), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(2), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6)	20639472	254	73	251	84	64	87	51	15	37	0	0.00019	0.0016
71	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(16), CR2(3), FCGR2B(1), HLA-DRA(2), HLA-DRB1(1), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13)	3080014	50	31	47	15	14	11	11	6	4	4	0.00026	0.0023
72	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(1), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(3), MAP2K2(1), NGFR(2), NTRK1(3), PIK3CA(23), PIK3CD(6), SHC1(3), SOS1(3)	3343088	54	36	42	16	13	20	17	3	1	0	0.00031	0.0027
73	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR1B(4), ACVR1C(3), ACVR2A(16), ACVR2B(3), ACVRL1(2), AMH(1), AMHR2(3), BMP2(2), BMP4(5), BMP5(5), BMP6(4), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(9), CHRD(1), COMP(1), CREBBP(11), CUL1(5), DCN(2), E2F5(1), EP300(10), FST(1), GDF5(1), GDF6(5), GDF7(1), IFNG(2), INHBA(4), INHBB(7), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(9), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), RBL1(3), RBL2(1), RHOA(4), ROCK1(5), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(7), SMAD3(2), SMAD4(5), SMAD5(1), SMAD6(2), SMAD7(1), SMAD9(4), SMURF1(1), SP1(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNF(1), ZFYVE16(5), ZFYVE9(2)	20249782	230	66	211	86	56	70	44	14	44	2	0.00035	0.0029
74	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(3), MAPK3(1), NFKB1(4), PIK3CA(23), PIK3R1(5), RAF1(6), RALBP1(7), RALGDS(6), RELA(2), RHOA(4)	3904614	68	37	55	16	15	18	22	6	7	0	0.00037	0.0031
75	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(2), CFL1(1), CHN1(3), LIMK1(2), MAP3K1(5), MYL2(1), MYLK(7), PAK1(2), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLD1(6), PPP1R12B(2), RALBP1(7), RPS6KB1(2), TRIO(20), VAV1(2), WASF1(3)	7060704	95	49	82	40	30	24	24	5	10	2	0.00041	0.0033
76	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNG(3), MUSK(3), PIK3CA(23), PIK3R1(5), PTK2(5), PTK2B(8), RAPSN(1), TERT(3)	3380062	54	34	42	20	16	14	17	1	6	0	0.00042	0.0034
77	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), GRB2(1), IGF1R(11), IRS1(5), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(23), PIK3R1(5), RAF1(6), SHC1(3), SOS1(3)	3799012	66	38	54	15	19	17	21	3	6	0	0.00052	0.0042
78	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(11), EP300(10), FYN(3), IL2RG(2), IL7R(3), JAK1(5), JAK3(3), LCK(1), NMI(1), PIK3CA(23), PIK3R1(5), PTK2B(8), STAT5B(4)	5698518	79	42	66	20	26	13	18	4	16	2	0.00060	0.0047
79	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), NGFR(2), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), SHC1(3), SOS1(3)	3871231	68	37	55	13	23	19	17	4	5	0	0.00068	0.0052
80	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), ELK1(2), GRB2(1), JAK1(5), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PDGFA(1), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1), STAT1(3), STAT3(4)	6989549	102	49	88	23	28	33	20	5	12	4	0.00068	0.0052
81	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX15(2), ALOX5(2), CBR1(1), CBR3(1), CYP4F2(1), CYP4F3(3), EPX(3), GGT1(7), LPO(2), LTA4H(4), MPO(5), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2), TPO(12)	5668593	74	44	72	20	27	25	11	6	5	0	0.00072	0.0054
82	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(3), GRB2(1), ITGB1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(23), PIK3R1(5), PTEN(5), PTK2(5), SHC1(3), SOS1(3)	3959942	56	35	44	14	15	10	19	3	9	0	0.00073	0.0055
83	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(8), MEF2B(2), MEF2C(1), MEF2D(3), NTRK1(3), PIK3CA(23), PIK3R1(5), PLCG1(9), RPS6KA1(2), SHC1(3)	3874556	69	38	56	14	22	23	17	1	6	0	0.00082	0.0061
84	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(1), CXCR4(2), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(2), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(4), PIK3C2G(3), PIK3CA(23), PIK3R1(5), PLCG1(9), PTK2(5), PTK2B(8), PXN(2), RAF1(6), RELA(2)	5742940	84	44	71	20	24	20	23	4	13	0	0.00084	0.0061
85	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(1), AKT3(3), BCR(4), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(3), ITPR1(13), ITPR2(12), ITPR3(10), LYN(2), NR0B2(1), PDK1(1), PHF11(2), PIK3CA(23), PITX2(2), PLCG2(5), PPP1R13B(3), PREX1(8), PTEN(5), PTPRC(13), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SAG(1), SYK(1), TEC(3), VAV1(2)	11263637	134	57	122	54	39	43	30	7	15	0	0.0012	0.0085
86	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), CDC42(1), PAK1(2), PDGFRA(2), PIK3CA(23), PIK3R1(5), WASL(1)	2678487	39	29	27	15	10	8	15	2	4	0	0.0012	0.0088
87	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPPL1(11), ITPKA(1), ITPKB(4), OCRL(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3CA(23), PIK3CB(4), PIK3CG(9), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCG1(9), PLCG2(5)	9204398	119	51	105	29	33	35	32	6	11	2	0.0013	0.0091
88	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRA2A(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCBP2(3), CCKAR(2), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CCR9(1), CCRL1(5), CHML(2), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CMKLR1(1), CNR1(4), CX3CR1(4), CXCR4(2), DRD1(2), DRD2(5), DRD3(7), DRD5(8), EDNRA(2), EDNRB(10), F2R(2), F2RL1(3), FPR1(1), FSHR(11), GALR1(2), GALR3(1), GALT(1), GHSR(4), GPR173(1), GPR174(1), GPR27(2), GPR3(3), GPR35(3), GPR37(1), GPR37L1(2), GPR4(2), GPR44(2), GPR50(3), GPR6(5), GPR83(4), GPR85(1), GPR87(4), GRPR(3), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), LHCGR(5), LTB4R(2), MAS1(1), MC3R(3), MC4R(2), MC5R(6), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(1), OPN1SW(1), OPN3(2), OPRD1(1), OPRK1(3), OR10A5(1), OR11A1(3), OR1F1(1), OR1Q1(3), OR2H1(1), OR5V1(1), OR7A5(1), OR7C1(1), OR8B8(5), OXTR(3), P2RY1(3), P2RY10(1), P2RY12(8), P2RY13(4), P2RY14(2), PPYR1(5), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(1), RRH(2), SSTR1(4), SSTR3(3), SSTR4(6), SUCNR1(1), TBXA2R(6), TRHR(5)	24610719	347	82	341	103	94	122	77	23	31	0	0.0013	0.0092
89	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(1), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(2), CREB1(4), CREB3(3), CREB5(2), EBP(1), ERBB4(12), GRB2(1), GSK3B(1), IGF1(2), IGFBP1(2), INPPL1(11), IRS1(5), IRS2(3), IRS4(9), MET(3), NOLC1(6), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARD3(6), PDK1(1), PIK3CA(23), PIK3CD(6), PPP1R13B(3), PREX1(8), PTEN(5), PTK2(5), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(3), SOS2(4), TSC1(1), TSC2(3), YWHAG(1), YWHAQ(2), YWHAZ(1)	15676843	176	66	162	60	48	51	45	9	23	0	0.0013	0.0093
90	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(8), BDKRB1(1), BDKRB2(2), C1QA(1), C1QC(2), C1R(6), C1S(3), C2(2), C3(11), C3AR1(2), C5(7), C5AR1(1), C6(7), C7(2), C8A(3), C8B(4), C9(3), CD46(1), CD55(1), CD59(1), CFB(3), CFH(9), CFI(2), CPB2(4), CR1(16), CR2(3), F10(3), F11(2), F12(2), F13A1(8), F13B(8), F2(4), F2R(2), F3(1), F5(8), F7(5), F8(9), F9(3), FGA(4), FGB(3), FGG(2), KLKB1(4), KNG1(2), MASP1(3), MASP2(2), MBL2(1), PLAT(2), PLAU(1), PLG(9), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(3), SERPINE1(1), SERPINF2(3), SERPING1(5), TFPI(2), THBD(1), VWF(8)	18373950	224	67	220	57	55	72	49	15	27	6	0.0014	0.0093
91	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(4), EPX(3), LPO(2), MPO(5), MTHFR(4), PRDX6(1), SHMT1(1), SHMT2(2), TPO(12)	2358622	35	25	35	8	14	12	3	1	5	0	0.0014	0.0097
92	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(1), AGTR2(1), ATP8A1(7), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCKAR(2), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CX3CR1(4), CXCR4(2), EDNRA(2), EDNRB(10), FPR1(1), FSHR(11), GALR1(2), GALR3(1), GALT(1), GHSR(4), GNRHR(2), GRPR(3), LHCGR(5), MC2R(1), MC3R(3), MC4R(2), MC5R(6), NMBR(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(1), OPRD1(1), OPRK1(3), OXTR(3), PPYR1(5), SSTR1(4), SSTR3(3), SSTR4(6), TAC4(1), TACR1(2), TACR2(1), TACR3(4), TRHR(5), TSHR(5)	10347932	142	56	139	41	27	55	30	17	13	0	0.0016	0.011
93	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(1), AKT3(3), BRD4(4), CBL(1), CDC42(1), CDKN2A(2), FLOT1(1), FLOT2(3), GRB2(1), GSK3B(1), IGFBP1(2), INPPL1(11), IRS1(5), IRS2(3), IRS4(9), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(6), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PPYR1(5), PTEN(5), RAF1(6), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SERPINB6(2), SHC1(3), SLC2A4(1), SORBS1(5), SOS1(3), SOS2(4), YWHAG(1), YWHAQ(2), YWHAZ(1)	12043948	151	59	138	47	44	50	32	6	19	0	0.0017	0.011
94	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(1), GH1(1), GHR(5), NFKB1(4), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), RELA(2)	2871603	46	30	34	10	13	7	18	3	5	0	0.0017	0.011
95	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), GRB2(1), NTRK1(3), PIK3CA(23), PIK3R1(5), PLCG1(9), SHC1(3), SOS1(3)	3147179	49	32	36	11	17	10	16	2	4	0	0.0018	0.011
96	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), ELAVL1(3), FLT1(5), FLT4(6), HIF1A(1), KDR(7), NOS3(2), PIK3CA(23), PIK3R1(5), PLCG1(9), PTK2(5), PXN(2), SHC1(3)	6926640	89	47	75	23	31	21	24	6	7	0	0.0019	0.012
97	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(1), ABLIM1(2), ABLIM2(3), ABLIM3(4), ARHGEF12(5), CDC42(1), CDK5(2), CFL1(1), CXCR4(2), DCC(17), DPYSL2(1), DPYSL5(4), EFNA2(2), EFNA5(1), EFNB1(1), EFNB2(3), EFNB3(4), EPHA1(6), EPHA2(3), EPHA3(10), EPHA4(5), EPHA5(10), EPHA6(9), EPHA7(2), EPHA8(7), EPHB1(9), EPHB2(10), EPHB3(4), EPHB4(4), EPHB6(6), FES(4), FYN(3), GNAI1(1), GNAI2(3), GNAI3(3), GSK3B(1), ITGB1(2), KRAS(7), L1CAM(3), LIMK1(2), LIMK2(3), LRRC4C(3), MAPK1(2), MAPK3(1), MET(3), NCK1(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NGEF(4), NRP1(8), NTN1(2), NTN4(1), NTNG1(3), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLXNA1(10), PLXNA2(12), PLXNA3(5), PLXNB1(5), PLXNB3(4), PLXNC1(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTK2(5), RAC2(1), RASA1(10), RGS3(7), RHOA(4), ROBO1(11), ROBO2(9), ROBO3(6), ROCK1(5), ROCK2(2), SEMA3A(3), SEMA3D(5), SEMA3E(6), SEMA3F(7), SEMA3G(3), SEMA4A(3), SEMA4B(2), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA5A(10), SEMA5B(4), SEMA6A(4), SEMA6B(2), SEMA6C(3), SEMA6D(6), SEMA7A(2), SLIT1(3), SLIT2(13), SLIT3(8), SRGAP1(7), SRGAP2(5), SRGAP3(4), UNC5A(5), UNC5B(3), UNC5C(8), UNC5D(5)	40504219	474	93	465	182	115	150	119	34	54	2	0.0020	0.013
98	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(3), CD14(1), CD1A(1), CD1B(2), CD1D(4), CD1E(4), CD2(2), CD33(2), CD34(2), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(2), CD4(3), CD44(3), CD5(4), CD55(1), CD59(1), CD8A(1), CR1(16), CR2(3), CSF1R(7), CSF3(1), CSF3R(3), EPOR(2), FCER2(1), FLT3(4), GP1BA(1), GP5(2), GYPA(1), HLA-DRA(2), HLA-DRB1(1), IL11(1), IL11RA(1), IL1B(1), IL1R1(2), IL2RA(1), IL3(1), IL6(1), IL7R(3), ITGA1(4), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGAM(4), ITGB3(5), KIT(5), KITLG(3), MME(2), TFRC(1), THPO(2), TNF(1), TPO(12)	16348094	162	62	158	70	41	46	34	14	23	4	0.0020	0.013
99	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(7), GPRC5B(1), GPRC5C(2), GRM1(11), GRM2(8), GRM3(3), GRM4(3), GRM5(11), GRM7(6), GRM8(8)	4204662	66	39	66	25	19	27	14	2	4	0	0.0020	0.013
100	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(1), ABL2(2), AKT1(2), AKT2(1), AKT3(3), ARAF(6), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CRK(1), EGF(4), EGFR(7), EIF4EBP1(1), ELK1(2), ERBB2(4), ERBB3(12), ERBB4(12), EREG(2), GRB2(1), GSK3B(1), JUN(2), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), NCK1(2), NCK2(2), NRG1(8), NRG2(4), NRG3(8), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PRKCG(4), PTK2(5), RAF1(6), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), STAT5B(4), TGFA(2)	21047915	265	71	247	88	67	89	68	11	30	0	0.0021	0.013
101	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(12), NRG2(4), NRG3(8), PSEN1(1)	1806539	26	22	25	5	4	5	14	1	2	0	0.0022	0.013
102	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CREB1(4), CREB3(3), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(11), CTNNB1(8), DCT(5), DVL1(3), DVL2(2), DVL3(3), EDN1(2), EDNRB(10), EP300(10), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GSK3B(1), KIT(5), KITLG(3), KRAS(7), LEF1(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), POMC(5), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), RAF1(6), TCF7(1), TCF7L1(3), TCF7L2(3), TYR(1), TYRP1(4), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2)	22337350	296	73	288	120	81	106	59	15	35	0	0.0022	0.013
103	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(6), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(1), FCGR3A(1), FCGR3B(1), FYN(3), GRB2(1), HLA-A(8), HLA-B(10), HLA-C(4), HLA-E(3), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(6), ITGB2(5), KIR2DL1(3), KIR2DL3(1), KIR2DL4(3), KIR3DL1(1), KLRC1(1), KLRC2(1), KLRD1(1), KRAS(7), LCK(1), LCP2(6), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), PAK1(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(8), PTPN11(3), RAC2(1), RAF1(6), SH2D1A(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), SYK(1), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(2), ULBP1(2), VAV1(2), VAV2(5), VAV3(6), ZAP70(3)	23019640	291	69	274	81	76	82	74	17	40	2	0.0023	0.014
104	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(9), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2G(3), CREB1(4), GNAS(12), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3CA(23), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RPS6KA1(2), SOS1(3)	5841094	83	45	70	24	24	25	20	5	9	0	0.0023	0.014
105	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(6), ESR1(4), ESR2(5), HNF4A(4), NR0B1(2), NR1D1(1), NR1D2(3), NR1H2(3), NR1I2(2), NR2C2(3), NR2F1(3), NR2F2(2), NR2F6(1), NR3C1(3), NR4A1(1), NR4A2(4), NR5A1(4), PGR(5), PPARA(2), PPARD(4), PPARG(1), RARA(1), RARB(5), ROR1(5), RORA(2), RORC(3), RXRA(2), RXRG(2), THRA(1), THRB(4), VDR(5)	8609489	98	52	97	38	21	37	23	6	11	0	0.0025	0.015
106	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), CHST1(8), CHST2(6), CHST6(4), FUT8(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1)	2560782	45	32	44	21	14	19	9	1	2	0	0.0025	0.015
107	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAPK3(1), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), STAT1(3), STAT3(4), STAT5B(4), THPO(2)	6030220	87	42	73	14	24	26	20	4	11	2	0.0026	0.015
108	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(6), KERA(1), LUM(2)	722988	13	13	13	2	3	7	1	2	0	0	0.0027	0.015
109	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(7), SHMT1(1), SHMT2(2)	882588	11	11	10	4	3	2	1	3	2	0	0.0028	0.016
110	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(1), AKT3(3), BCL10(1), CARD11(7), CBL(1), CBLB(2), CBLC(2), CD247(2), CD3E(1), CD3G(2), CD4(3), CD40LG(3), CD8A(1), CDC42(1), CTLA4(2), FYN(3), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), IL2(1), ITK(2), JUN(2), KRAS(7), LCK(1), LCP2(6), MALT1(2), MAP3K14(1), NCK1(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), NFKB2(2), NFKBIB(3), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCQ(1), PTPRC(13), RASGRP1(3), RHOA(4), SOS1(3), SOS2(4), TEC(3), TNF(1), VAV1(2), VAV2(5), VAV3(6), ZAP70(3)	20667402	233	72	215	87	63	69	59	17	25	0	0.0031	0.018
111	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(18), AR(6), ASAH1(1), BRAF(5), DAG1(7), EGFR(7), GNA11(1), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), MAPK10(3), MAPK14(1), PHKA2(4), PIK3CA(23), PIK3CD(6), PIK3R1(5), PITX2(2), PTX3(1), RAF1(6)	10932334	147	54	134	48	35	47	38	6	17	4	0.0032	0.018
112	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(4), PAK1(2), PIK3CA(23), PIK3R1(5), RAF1(6), RB1(6), RELA(2)	4131246	60	36	47	15	15	13	20	4	8	0	0.0032	0.018
113	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(7), EIF4G2(1), EIF4G3(5), MKNK1(1), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), PTEN(5), RPS6(1), RPS6KB1(2), TSC1(1), TSC2(3)	5599167	67	40	55	29	15	21	20	4	7	0	0.0033	0.018
114	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(1), GGT1(7), SHMT1(1), SHMT2(2)	1172794	14	14	13	5	4	3	1	4	2	0	0.0034	0.018
115	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6)	1121589	22	17	21	3	1	5	5	6	5	0	0.0034	0.018
116	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(9), CD3E(1), CD3G(2), CD4(3), CREBBP(11), CSK(2), GNAS(12), GNB1(1), GNGT1(2), HLA-DRA(2), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTPRC(13), ZAP70(3)	4621883	75	38	73	31	20	24	11	8	12	0	0.0037	0.019
117	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(9), CD3E(1), CD3G(2), CD4(3), CREBBP(11), CSK(2), GNAS(12), GNB1(1), GNGT1(2), HLA-DRA(2), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTPRC(13), ZAP70(3)	4621883	75	38	73	31	20	24	11	8	12	0	0.0037	0.019
118	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(8), F2(4), F2R(2), FGA(4), FGB(3), FGG(2), PLAT(2), PLAU(1), PLG(9), SERPINB2(2), SERPINE1(1)	2669842	42	29	42	8	11	11	10	2	8	0	0.0037	0.019
119	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(12), GNB1(1), GNGT1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	1893654	30	24	29	7	6	17	1	3	3	0	0.0039	0.020
120	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(3), ACVR1B(4), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(9), BUB1(6), CDKL1(2), CDKL2(3), CDS1(2), CDS2(1), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPPL1(11), ITPKA(1), ITPKB(4), MAP3K10(5), MOS(3), NEK1(4), OCRL(3), PAK4(2), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3CA(23), PIK3CB(4), PIK3CG(9), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCG1(9), PLCG2(5), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), PRKD1(5), PRKG1(4), RAF1(6), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KB1(2), TGFBR1(1), VRK1(2)	23285906	257	72	241	75	67	82	57	17	30	4	0.0040	0.021
121	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(4), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(4), PIK3CA(23), PIK3R1(5), RB1(6), RELA(2), SP1(2)	3950233	64	36	51	12	15	13	23	5	8	0	0.0050	0.025
122	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(2), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(12)	1720621	26	21	26	8	13	8	1	2	2	0	0.0052	0.026
123	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MAPKAPK5(1), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PIK3CA(23), PIK3CD(6), PIK3R1(5), TRAF2(2), TRAF3(2), TRAF6(3)	6990480	94	46	82	22	27	32	19	3	13	0	0.0057	0.029
124	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(4), EPX(3), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(2), TPO(12)	2401714	31	24	31	9	14	10	2	0	5	0	0.0059	0.029
125	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), AKAP1(1), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(2), AKAP6(8), AKAP7(6), AKAP8(5), AKAP9(13), ARHGEF1(1), CALM1(1), CALM2(2), CALM3(1), CHMP1B(1), GNA11(1), GNA12(1), GNA14(1), GNA15(2), GNAI2(3), GNAI3(3), GNAQ(1), GNAZ(5), GNB1(1), GNB2(3), GNB3(1), GNG12(1), GNG7(2), GNGT1(2), GNGT2(1), ITPR1(13), KCNJ3(3), KRAS(7), PDE1A(2), PDE1B(1), PDE1C(2), PDE4A(4), PDE4B(4), PDE4C(2), PDE7A(5), PDE7B(2), PDE8A(5), PDE8B(2), PLCB3(6), PPP3CA(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PRKD1(5), PRKD3(1), RHOA(4), RRAS(1), SLC9A1(4), USP5(3)	23738106	235	68	226	88	62	67	58	17	31	0	0.0059	0.029
126	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(3), FYN(3), GSN(4), ITGA1(4), ITGB1(2), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PIK3CA(23), PIK3R1(5), PTK2(5), PXN(2), RAF1(6), ROCK1(5), SHC1(3), TLN1(9)	7567168	94	46	82	27	28	22	23	6	13	2	0.0065	0.032
127	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(1), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK1G(3), CAMK4(2), CREBBP(11), EDN1(2), F2(4), FGF2(1), GATA4(2), GSK3B(1), HAND1(2), HAND2(3), IGF1(2), LIF(2), MAP2K1(3), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MEF2C(1), MYH2(9), NFATC2(5), NFATC3(3), NFATC4(9), NKX2-5(2), PIK3CA(23), PIK3R1(5), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RAF1(6), RPS6KB1(2)	10185539	139	57	127	44	44	40	30	8	17	0	0.0066	0.032
128	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(2), GAD1(3), GAD2(3), GGT1(7)	1179045	16	16	15	3	4	8	1	3	0	0	0.0066	0.032
129	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(3), CD58(1), CD8A(1), CSF3(1), IL3(1), IL6(1), IL8(1), KITLG(3)	1271081	19	17	18	8	4	6	4	1	4	0	0.0069	0.033
130	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(2), AKT2(1), AKT3(3), BAD(1), BTK(1), CDKN2A(2), GRB2(1), GSK3B(1), IARS(6), IGFBP1(2), INPP5D(1), PDK1(1), PIK3CA(23), PPP1R13B(3), PTEN(5), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SHC1(3), SOS1(3), SOS2(4), TEC(3), YWHAG(1), YWHAQ(2), YWHAZ(1)	7278824	80	45	68	30	26	21	20	3	10	0	0.0079	0.037
131	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(3), COMT(1), DBH(2), DCT(5), DDC(3), FAH(2), GOT1(2), GOT2(2), GSTZ1(1), HPD(1), MAOA(1), MAOB(2), PNMT(2), TAT(1), TH(1), TPO(12), TYR(1)	6224932	83	42	82	19	18	33	9	10	9	4	0.0080	0.038
132	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(1), AKT3(3), BTK(1), FYN(3), GRB2(1), IL13(1), IL3(1), INPP5D(1), KRAS(7), LCP2(6), LYN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(1), PDK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCG1(9), PLCG2(5), PRKCD(2), PRKCE(3), RAC2(1), RAF1(6), SOS1(3), SOS2(4), SYK(1), TNF(1), VAV1(2), VAV2(5), VAV3(6)	14666841	182	62	167	59	51	60	43	14	14	0	0.0087	0.041
133	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(3), CSF3(1), HLA-DRA(2), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(1), IL12B(1), IL13(1), IL2(1), IL3(1), IL6(1), IL8(1), LTA(1), PDGFA(1), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1)	2687531	32	25	32	14	4	12	11	3	2	0	0.0089	0.041
134	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(2), HLA-A(8), ICAM1(2), ITGAL(6), ITGB2(5), PRF1(1)	1749216	27	21	26	8	5	8	4	3	7	0	0.010	0.047
135	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), AKT1(2), ANGPTL2(3), DAG1(7), DGKA(1), ETFA(1), GCA(2), ITGA9(6), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), MAP2K1(3), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(3), PDE3B(9), PI3(2), PIK3C2G(3), PIK3CA(23), PIK3CD(6), PIK3R1(5), RIPK3(2), VASP(2)	10035781	127	53	115	41	23	45	33	8	16	2	0.010	0.047
136	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(1), AKT3(3), AMOTL1(4), ASH1L(16), CASK(3), CDC42(1), CGN(5), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CSDA(4), CSNK2A1(4), CSNK2A2(1), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTTN(1), EPB41(7), EPB41L1(2), EPB41L2(7), EPB41L3(9), EXOC3(4), EXOC4(1), GNAI1(1), GNAI2(3), GNAI3(3), HCLS1(1), IGSF5(1), INADL(4), JAM3(2), KRAS(7), LLGL1(4), LLGL2(3), MAGI1(11), MAGI2(7), MAGI3(4), MLLT4(12), MPDZ(12), MPP5(1), MYH1(6), MYH10(13), MYH11(11), MYH13(10), MYH14(8), MYH15(6), MYH2(9), MYH3(13), MYH4(9), MYH6(7), MYH7(11), MYH7B(10), MYH8(7), MYH9(13), MYL2(1), PARD3(6), PARD6B(1), PARD6G(2), PPM1J(3), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PTEN(5), RAB3B(3), RHOA(4), RRAS(1), RRAS2(1), SPTAN1(8), SYMPK(4), TJAP1(2), TJP1(4), TJP2(5), TJP3(4), YES1(2), ZAK(2)	39463361	440	84	434	134	101	173	78	38	48	2	0.010	0.047
137	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), ARHGAP5(6), BCAR1(3), CDC42(1), CDH5(2), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTNND1(5), CXCR4(2), CYBA(1), CYBB(2), ESAM(4), GNAI1(1), GNAI2(3), GNAI3(3), GRLF1(8), ICAM1(2), ITGA4(7), ITGAL(6), ITGAM(4), ITGB1(2), ITGB2(5), ITK(2), JAM3(2), MAPK13(1), MAPK14(1), MLLT4(12), MMP2(3), MMP9(5), MSN(3), MYL2(1), NCF1(1), NCF4(1), NOX1(4), NOX3(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PRKCG(4), PTK2(5), PTK2B(8), PTPN11(3), PXN(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(4), RHOH(1), ROCK1(5), ROCK2(2), TXK(1), VASP(2), VAV1(2), VAV2(5), VAV3(6), VCAM1(4), VCL(2)	25622317	304	76	288	123	76	107	66	19	34	2	0.013	0.059
138	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPP5B(2), INPP5E(2), INPPL1(11), IPMK(1), ISYNA1(2), ITGB1BP3(3), ITPK1(1), ITPKA(1), ITPKB(4), MINPP1(3), OCRL(3), PI4KA(6), PI4KB(4), PIK3C3(4), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PTEN(5), PTPMT1(1), SYNJ1(5), SYNJ2(13)	15216796	188	60	172	51	50	65	42	9	20	2	0.015	0.067
139	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(12), TYR(1)	1969331	25	21	25	8	13	8	1	1	2	0	0.015	0.067
140	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(2), CALM3(1), CD3E(1), CD3G(2), ELK1(2), FYN(3), GRB2(1), JUN(2), LCK(1), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), PIK3CA(23), PIK3R1(5), PLCG1(9), PPP3CA(2), PPP3CB(1), PTPN7(2), RAF1(6), RASA1(10), RELA(2), SHC1(3), SOS1(3), VAV1(2), ZAP70(3)	9684927	126	51	111	27	37	32	28	6	21	2	0.017	0.073
141	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(3), CARM1(1), COMT(1), DBH(2), DCT(5), DDC(3), ESCO2(1), FAH(2), GOT1(2), GOT2(2), GSTZ1(1), HPD(1), LCMT1(1), LCMT2(4), MAOA(1), MAOB(2), METTL6(1), MYST3(6), MYST4(12), NAT6(1), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(1), TAT(1), TH(1), TPO(12), TYR(1), TYRP1(4), WBSCR22(1)	11825828	127	52	126	29	29	45	19	13	17	4	0.017	0.074
142	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(4), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), RAF1(6), SOS1(3), STAT1(3), STAT5B(4)	5651835	75	41	63	21	19	24	18	3	11	0	0.017	0.075
143	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GPX1(1), PRKCE(3)	1592808	27	18	27	7	3	9	10	4	1	0	0.019	0.082
144	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), ESCO2(1), GOT1(2), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(2), MPO(5), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(12)	6891129	76	43	76	18	22	27	12	6	7	2	0.020	0.083
145	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(2), CD4(3), FYN(3), HLA-DRA(2), HLA-DRB1(1), LCK(1), PTPRC(13), ZAP70(3)	1841119	29	21	28	15	8	6	6	5	4	0	0.020	0.083
146	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(3), CHAD(3), COL11A1(12), COL11A2(5), COL17A1(4), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), COMP(1), DES(1), DSC1(2), DSC2(3), DSC3(3), DSG1(3), DSG3(4), DSG4(3), FN1(15), GJA1(7), GJA10(2), GJA3(1), GJA4(4), GJA8(1), GJA9(1), GJB3(2), GJB6(2), GJC2(2), GJD2(1), GJD4(4), IBSP(1), INA(3), ITGA6(2), ITGB4(10), KRT1(1), KRT10(1), KRT12(4), KRT13(5), KRT14(2), KRT15(1), KRT16(2), KRT17(1), KRT18(3), KRT2(6), KRT20(2), KRT23(1), KRT25(2), KRT27(3), KRT28(3), KRT3(1), KRT31(3), KRT32(1), KRT33A(5), KRT33B(4), KRT34(1), KRT35(2), KRT36(3), KRT37(3), KRT38(1), KRT5(3), KRT6A(3), KRT6B(1), KRT6C(2), KRT7(2), KRT71(1), KRT72(5), KRT73(3), KRT74(3), KRT76(2), KRT77(1), KRT78(2), KRT79(1), KRT81(1), KRT82(1), KRT83(2), KRT84(3), KRT85(2), KRT86(1), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), LMNA(2), LMNB1(1), LMNB2(3), NES(2), PRPH(1), RELN(15), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNC(11), TNN(10), TNR(9), TNXB(20), VIM(1), VTN(4), VWF(8)	50662892	508	84	506	233	142	192	84	37	53	0	0.020	0.083
147	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), CREBBP(11), DAG1(7), EGR1(3), EGR2(3), EGR3(1), EGR4(3), ELK1(2), FRS2(1), GNAQ(1), JUN(2), MAP1B(5), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), NTRK1(3), OPN1LW(3), PIK3C2G(3), PIK3CA(23), PIK3CD(6), PIK3R1(5), PTPN11(3), SHC1(3), TERF2IP(3), TH(1)	10657157	141	52	129	51	36	56	23	5	21	0	0.020	0.083
148	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM1(1), CALM2(2), CALM3(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP2K4(5), MAP2K7(8), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), PAK2(3), PIK3CA(23), PIK3R1(5), PLA2G4A(3), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(6), SHC1(3), SOS1(3), SYK(1), VAV1(2)	8692614	118	50	105	25	34	37	29	3	15	0	0.022	0.092
149	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(1), GNB1(1), GNGT1(2), HTR2C(2), PLCB1(8), TUB(3)	1437863	18	16	18	8	3	7	3	0	5	0	0.023	0.094
150	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(2), CALM3(1), CDS1(2), CDS2(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(11), ITGB1BP3(3), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), OCRL(3), PI4KA(6), PI4KB(4), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3C3(4), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PRKCG(4), PTEN(5), PTPMT1(1), SYNJ1(5), SYNJ2(13)	25712092	279	71	262	88	70	96	62	15	34	2	0.024	0.098
151	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), AVP(3), CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), HDAC5(3), IGF1(2), IGF1R(11), INSR(7), MAP2K6(2), MAPK14(1), MAPK7(8), MEF2B(2), MEF2C(1), MEF2D(3), MYOD1(3), NFATC2(5), PIK3CA(23), PIK3R1(5), PPP3CA(2), PPP3CB(1)	7104195	99	47	87	22	28	34	23	6	8	0	0.026	0.10
152	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(3), HLA-DRA(2), HLA-DRB1(1), IL3(1)	610736	8	8	8	3	2	3	1	1	1	0	0.026	0.11
153	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(1), AKT3(3), BCL10(1), BLNK(1), BTK(1), CARD11(7), CD79A(5), CD81(2), CR2(3), FCGR2B(1), GSK3B(1), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), KRAS(7), LILRB3(2), LYN(2), MALT1(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), NFKB2(2), NFKBIB(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), RAC2(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(5), VAV3(6)	15141518	159	57	143	66	45	49	39	8	18	0	0.027	0.11
154	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GPHN(3), NSF(2), UBQLN1(1)	2412886	33	22	33	10	2	10	12	4	5	0	0.027	0.11
155	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(1), AKT3(3), CASP8(3), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(2), CXCL9(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IKBKB(3), IKBKE(2), IL12B(1), IL1B(1), IL6(1), IL8(1), IRAK1(4), IRAK4(1), IRF3(3), IRF5(1), IRF7(1), JUN(2), LY96(1), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K7(7), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(1), MYD88(2), NFKB1(4), NFKB2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), RELA(2), STAT1(3), TICAM1(3), TIRAP(1), TLR1(5), TLR2(2), TLR3(1), TLR4(9), TLR5(1), TLR7(3), TLR8(6), TLR9(7), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(3)	18254250	210	66	194	63	40	73	58	12	27	0	0.028	0.11
156	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(7), ERBB3(12), NRG1(8)	2063894	31	22	31	13	11	9	6	1	4	0	0.029	0.11
157	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(9), SCAP(7), SREBF1(3), SREBF2(5)	2488962	28	22	28	14	5	10	8	3	2	0	0.030	0.12
158	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), AKT1(2), AKT2(1), AKT3(3), ANGPTL2(3), ARHGAP4(1), ARHGEF11(8), BTK(1), CDC42(1), CFL1(1), GDI1(1), INPPL1(11), ITPR1(13), ITPR2(12), ITPR3(10), LIMK1(2), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3CG(9), PIK3R1(5), PITX2(2), PPP1R13B(3), PTEN(5), RACGAP1(2), RHO(1), ROCK1(5), ROCK2(2), SAG(1), WASF1(3), WASL(1)	14361473	163	56	150	56	47	51	38	9	18	0	0.032	0.12
159	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), NAT1(1), NAT2(5), XDH(8)	1592675	25	19	24	7	9	7	7	2	0	0	0.032	0.12
160	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT1(2), AKT2(1), AKT3(3), CBL(1), CBLB(2), CBLC(2), CCND2(1), CCND3(2), CISH(2), CLCF1(1), CNTF(2), CNTFR(2), CREBBP(11), CSF2RB(5), CSF3(1), CSF3R(3), EP300(10), EPOR(2), GH1(1), GH2(2), GHR(5), GRB2(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(1), IL10RB(1), IL11(1), IL11RA(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL13(1), IL13RA1(1), IL13RA2(4), IL15RA(1), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23R(5), IL26(1), IL28A(1), IL28B(1), IL2RA(1), IL2RG(2), IL3(1), IL6(1), IL6ST(1), IL7R(3), IRF9(4), JAK1(5), JAK2(4), JAK3(3), LEPR(7), LIF(2), LIFR(6), OSM(2), OSMR(3), PIAS1(3), PIAS2(4), PIAS3(1), PIAS4(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIM1(1), PRL(1), PRLR(2), PTPN11(3), SOCS2(2), SOCS3(2), SOCS4(1), SOCS7(2), SOS1(3), SOS2(4), SPRED1(2), SPRED2(4), SPRY1(2), SPRY2(1), SPRY4(3), STAM(3), STAM2(1), STAT1(3), STAT2(1), STAT3(4), STAT4(4), STAT5B(4), TPO(12), TSLP(3), TYK2(4)	28691558	307	77	292	99	69	99	80	21	36	2	0.033	0.13
161	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(9), GNAS(12), GNB1(1), GNGT1(2), PRKACA(1), PRKAR1A(2)	1348487	27	17	26	8	7	13	2	1	4	0	0.034	0.13
162	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), DRD1(2), DRD2(5), GRM1(11), PLCB1(8), PPP1CA(2), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	3162740	45	30	45	18	14	15	7	4	5	0	0.034	0.13
163	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(1), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(1), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PRKAA1(1), PRKAA2(2), RHEB(1), RICTOR(4), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6), RPS6KB1(2), RPS6KB2(2), TSC1(1), TSC2(3), ULK1(1), ULK2(2), ULK3(1), VEGFC(3)	10939782	114	51	102	44	29	42	30	4	9	0	0.034	0.13
164	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(4), F2R(2), F3(1), F5(8), F7(5), FGA(4), FGB(3), FGG(2), PROC(2), SERPINC1(2), TFPI(2)	3283504	38	28	38	14	8	12	14	1	3	0	0.035	0.13
165	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(4), BLNK(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8IP3(7), PAPPA(12), RPS6KA1(2), SHC1(3), SOS1(3), SYK(1), VAV1(2), VAV2(5), VAV3(6)	6536418	64	40	64	34	13	24	13	5	9	0	0.036	0.14
166	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(2), CD8A(1), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13)	2154866	32	21	31	15	7	9	8	3	5	0	0.037	0.14
167	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), GOT1(2), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(2), MPO(5), PRDX6(1), TAT(1), TPO(12)	4443530	54	33	54	15	18	21	5	4	4	2	0.037	0.14
168	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(3)	1125845	14	14	14	5	8	2	3	1	0	0	0.041	0.15
169	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), CFL1(1), GNAQ(1), GNAS(12), GNB1(1), GNGT1(2), LIMK1(2), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(8), PPP1R12B(2), PTK2(5), RAF1(6), ROCK2(2)	5173168	59	35	58	18	9	27	10	2	11	0	0.042	0.15
170	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(7), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), GLCE(2), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(2), HS6ST1(2), HS6ST2(1), HS6ST3(3), NDST1(8), NDST2(5), NDST3(3), NDST4(7)	4275684	63	35	63	25	17	26	15	0	5	0	0.042	0.15
171	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(1), AKT3(3), BAD(1), BCR(4), BLNK(1), BTK(1), CSK(2), DAG1(7), EPHB2(10), GRB2(1), ITPKA(1), ITPKB(4), LYN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PI3(2), PIK3CA(23), PIK3CD(6), PIK3R1(5), PLCG2(5), PPP1R13B(3), RAF1(6), SERPINA4(1), SHC1(3), SOS1(3), SOS2(4), SYK(1), VAV1(2)	10709426	130	51	115	38	29	37	34	9	19	2	0.043	0.15
172	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(1), ACTN1(2), ACTR2(2), AKT1(2), AKT2(1), AKT3(3), ANGPTL2(3), ARHGEF6(8), ARHGEF7(7), BCAR1(3), BRAF(5), CAV1(2), CDC42(1), CDKN2A(2), CRK(1), CSE1L(2), DOCK1(10), EPHB2(10), FYN(3), GRB2(1), GRB7(6), GRLF1(8), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGB3BP(1), MAP2K4(5), MAP2K7(8), MAP3K11(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MYLK(7), MYLK2(2), P4HB(1), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(23), PIK3CB(4), PKLR(4), PLCG1(9), PLCG2(5), PTEN(5), PTK2(5), RAF1(6), RHO(1), ROCK1(5), ROCK2(2), SHC1(3), SOS1(3), SOS2(4), TERF2IP(3), TLN1(9), TLN2(11), VASP(2), ZYX(2)	24984316	296	72	280	98	92	91	52	20	41	0	0.044	0.16
173	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ABP1(6), ACADL(1), ACADM(1), ACADSB(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DPYD(12), DPYS(1), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), MLYCD(2), SDS(1), SMS(2), UPB1(2)	5860379	69	35	68	15	18	25	13	5	6	2	0.044	0.16
174	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(1), AKT3(3), ASAH1(1), BRAF(5), DAG1(7), DRD2(5), EGFR(7), EPHB2(10), GRB2(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), PI3(2), PIK3CB(4), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), RAF1(6), RGS20(2), SHC1(3), SOS1(3), SOS2(4), STAT3(4), TERF2IP(3)	11970399	143	49	140	54	35	56	24	7	19	2	0.045	0.16
175	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(6), AGXT(1), AGXT2(4), ALAS2(4), AMT(3), AOC2(4), AOC3(2), BHMT(5), CBS(3), CHDH(3), CHKA(1), CTH(2), DAO(3), DLD(2), DMGDH(1), GARS(1), GATM(1), GCAT(3), GLDC(5), MAOA(1), MAOB(2), PEMT(1), PISD(2), PLCB2(3), PLCG1(9), PLCG2(5), PSPH(2), SARDH(2), SARS(2), SHMT1(1), SHMT2(2), TARS(3)	8610819	89	43	88	34	21	29	17	10	10	2	0.045	0.16
176	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), CD36(1), CITED2(1), CREBBP(11), DUSP1(1), DUT(1), EHHADH(1), EP300(10), HSD17B4(2), JUN(2), LPL(1), MAPK1(2), MAPK3(1), ME1(3), NCOA1(7), NCOR1(10), NCOR2(12), NR0B2(1), NR2F1(3), NRIP1(7), PDGFA(1), PIK3CA(23), PIK3R1(5), PPARA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTGS2(1), RB1(6), RELA(2), RXRA(2), SP1(2), STAT5B(4), TNF(1)	12674501	140	54	127	39	36	39	37	6	22	0	0.046	0.16
177	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(4), IGF1(2), IL11(1), IL3(1), IL6(1), KITLG(3), TGFB1(2), TGFB2(4), TGFB3(3)	1711444	22	18	22	7	4	8	5	2	3	0	0.046	0.16
178	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(4), EGFR(7), GRB2(1), MAP2K1(3), MAPK1(2), MAPK3(1), PTPRB(10), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SPRY1(2), SPRY2(1), SPRY4(3)	4923926	57	33	56	16	13	19	10	2	11	2	0.047	0.16
179	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(1), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(7), KRAS(7), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(3), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NOS3(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCG1(9), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(1), PTK2(5), PXN(2), RAC2(1), RAF1(6), SH2D2A(1), SHC2(2), SPHK1(4)	14866873	174	57	158	51	51	57	42	9	15	0	0.050	0.17
180	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(9), FSHB(1), FSHR(11), GNAS(12), XPO1(2)	1941002	35	21	33	12	8	15	7	2	3	0	0.050	0.17
181	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(7), C6(7), C7(2), ICAM1(2), IL6(1), IL8(1), ITGA4(7), ITGAL(6), ITGB1(2), ITGB2(5), SELP(2), SELPLG(5), TNF(1), VCAM1(4)	5023277	63	34	63	21	14	23	13	6	7	0	0.051	0.17
182	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	CNR1(4), DNMT1(10), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(6)	2366336	37	24	37	13	8	20	7	0	2	0	0.052	0.17
183	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(2), CALCRL(4), CD97(1), CRHR1(1), CRHR2(3), ELTD1(8), EMR1(8), EMR2(2), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(6), LPHN2(10), LPHN3(9), SCTR(2), VIPR1(2)	5550223	72	38	72	16	22	23	17	4	6	0	0.052	0.17
184	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(13), MAP2(13), PPP1CA(2), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAR2A(1), PRKAR2B(5), PRKCE(3)	3661357	43	28	42	17	7	10	15	7	4	0	0.055	0.18
185	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ABP1(6), ACADM(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DPYD(12), DPYS(1), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), MLYCD(2), SMS(2), SRM(1), UPB1(2)	5464438	59	33	58	13	16	21	12	3	5	2	0.056	0.19
186	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(2), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(1), GCNT2(2), PIGA(2), PIGB(3), PIGC(1), PIGG(5), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(3), PIGV(2), PIGX(2), PIGZ(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(3), ST8SIA5(2)	10013038	83	49	82	29	21	32	16	8	6	0	0.058	0.19
187	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	144172	3	3	3	1	1	0	1	0	1	0	0.059	0.20
188	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(8), GLS(4), GLUD1(3), GOT1(2)	1502767	22	17	22	5	3	10	7	0	2	0	0.060	0.20
189	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CSK(2), CTLA4(2), DAG1(7), EPHB2(10), FBXW7(8), GRAP2(1), GRB2(1), ITK(2), ITPKA(1), ITPKB(4), LCK(1), LCP2(6), MAPK1(2), NCK1(2), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLCG1(9), PTPRC(13), RAF1(6), RASGRP1(3), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(3), SOS2(4), VAV1(2), ZAP70(3)	11416986	131	47	125	43	30	37	31	10	21	2	0.061	0.20
190	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(8), HSD17B1(1), HSD17B2(1), HSD17B3(2), HSD17B4(2), HSD17B7(1), HSD3B1(1), HSD3B2(1)	1634304	18	16	18	4	3	5	6	1	3	0	0.062	0.20
191	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(4), ARRB2(2), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CLCA1(2), CLCA2(4), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(6), GUCA1A(1), PDE1C(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKG1(4), PRKG2(6), PRKX(1)	6165614	62	37	60	23	4	22	22	6	8	0	0.062	0.20
192	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(3), BCAR1(3), CAPN1(1), CAPN11(3), CAPN2(3), CAPN3(4), CAPN5(2), CAPN6(5), CAPN7(5), CAPN9(3), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(2), DOCK1(10), FYN(3), GIT2(1), GRB2(1), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAD(3), ITGAE(4), ITGAL(6), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(2), ITGB2(5), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAPK10(3), MAPK4(3), MAPK6(1), MAPK7(8), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(3), PTK2(5), PXN(2), RAC2(1), RAP1B(2), RAPGEF1(6), RHO(1), ROCK1(5), ROCK2(2), SHC1(3), SHC3(3), SORBS1(5), SOS1(3), TLN1(9), TNS1(12), VASP(2), VAV2(5), VAV3(6), VCL(2), ZYX(2)	27556004	277	73	277	119	87	83	49	22	36	0	0.063	0.20
193	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(7), ELK1(2), GNAS(12), GNB1(1), GNGT1(2), GRB2(1), IGF1R(11), ITGB1(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(2), PDGFRA(2), PPP2CA(1), PTPRR(4), RAF1(6), RPS6KA1(2), SHC1(3), SOS1(3), STAT3(4)	6778478	73	38	72	29	14	34	11	4	10	0	0.063	0.20
194	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AKR1C4(1), AKR1D1(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(2), SRD5A1(2), SRD5A2(2)	4716712	66	31	65	14	10	27	13	6	10	0	0.064	0.20
195	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(9), GNAS(12), GNB1(1), GNGT1(2), PPP2CA(1), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	3052217	45	27	44	18	12	20	4	3	6	0	0.064	0.20
196	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(7), ITGAL(6), ITGAM(4), ITGB1(2), ITGB2(5), SELE(2), SELL(3), SELP(2)	3525830	36	26	36	22	9	12	3	5	7	0	0.068	0.21
197	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(2), AKT1(2), APC(18), ASAH1(1), DAG1(7), DLG4(4), EPHB2(10), GNAI1(1), GNAQ(1), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), PITX2(2), PTX3(1), RHO(1), RYR1(24)	9417464	114	45	110	46	26	44	18	6	18	2	0.069	0.21
198	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(2), CD4(3), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13)	2267384	34	20	33	18	6	11	8	4	5	0	0.070	0.22
199	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), FCGR3A(1), IL1B(1), SELL(3), TGFB1(2), TGFB2(4), TNF(1), TNFRSF1A(3), TNFRSF8(2), TNFSF8(1)	2823723	25	21	25	13	6	6	6	2	5	0	0.070	0.22
200	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(18), ASAH1(1), CASP3(1), CERK(3), CREB1(4), CREB3(3), CREB5(2), CXCL2(1), DAG1(7), EPHB2(10), GNAQ(1), ITPKA(1), ITPKB(4), JUN(2), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1)	5877403	89	34	85	21	22	32	12	1	18	4	0.077	0.24
201	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(11), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(3), CTNNA2(9), CTNNB1(8), PTK2(5), PXN(2), VCL(2)	4250281	48	30	47	21	14	15	10	5	4	0	0.077	0.24
202	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(1), HDAC3(3), NCOA1(7), NCOA2(10), NCOA3(7), NCOR2(12), POLR2A(6), RARA(1), RXRA(2), TBP(2)	5151888	62	34	62	24	15	30	6	4	7	0	0.078	0.24
203	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRA2A(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), DRD1(2), DRD2(5), DRD3(7), DRD5(8), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3)	5232486	88	38	85	29	29	26	19	6	8	0	0.078	0.24
204	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(2), GRIA2(8)	793079	12	11	12	5	5	2	2	2	1	0	0.078	0.24
205	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(2), FUT8(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1)	1620073	22	20	21	8	10	7	4	0	1	0	0.079	0.24
206	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(6), AGXT(1), AGXT2(4), AKR1B10(1), ALAS2(4), AMT(3), AOC2(4), AOC3(2), BHMT(5), CBS(3), CHDH(3), CHKA(1), CTH(2), DAO(3), DLD(2), DMGDH(1), GARS(1), GATM(1), GCAT(3), GLDC(5), GNMT(2), HSD3B7(1), MAOA(1), MAOB(2), PEMT(1), PHGDH(1), PIPOX(2), PISD(2), PSPH(2), RDH11(1), RDH12(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT1(1), SHMT2(2), TARS(3), TARS2(5)	8739031	88	42	88	34	21	29	17	10	9	2	0.085	0.25
207	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), MAPK1(2), RAF1(6), SNX13(5), TERF2IP(3)	2340667	32	25	32	9	7	14	3	3	5	0	0.086	0.25
208	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(4), GLI2(5), GLI3(11), GSK3B(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), SMO(6), SUFU(3)	3336571	46	26	46	22	11	18	6	4	7	0	0.087	0.26
209	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(1), AKT3(3), BAD(1), GRB2(1), GSK3B(1), IRS1(5), IRS2(3), JAK1(5), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PPP1R13B(3), RAF1(6), SHC1(3), SOS1(3), SOS2(4)	7529529	84	43	71	27	27	21	21	6	7	2	0.087	0.26
210	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(2), CD5(4), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL3(1), ITGAX(5), TLR2(2), TLR4(9), TLR7(3), TLR9(7)	3737034	46	28	43	23	5	17	19	1	4	0	0.090	0.27
211	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(6), AOC2(4), AOC3(2), CES1(5), ESD(1)	1204182	18	13	18	5	4	8	3	1	0	2	0.093	0.27
212	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCKBR(3), CCR2(1), CCR3(3), CELSR1(13), CELSR2(15), CELSR3(15), CHRM2(6), CHRM3(4), CIDEB(1), EDNRA(2), EMR2(2), EMR3(3), F2R(2), FSHR(11), GNRHR(2), GPR116(8), GPR132(1), GPR133(6), GPR135(2), GPR143(1), GPR55(5), GPR61(3), GPR84(1), GRM1(11), GRPR(3), LGR6(2), LPHN2(10), LPHN3(9), LTB4R2(2), NTSR1(1), OR8G2(4), P2RY13(4), PTGFR(3), SMO(6), TAAR5(1), TSHR(5), VN1R1(3)	13575975	176	55	173	46	37	65	45	13	16	0	0.097	0.28
213	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(4), AKR1B1(3), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CEL(6), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), GK(2), GLB1(2), LCT(10), LIPC(1), LIPF(1), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(2), PNLIPRP2(2), PPAP2C(4)	9731743	105	44	104	37	20	41	19	12	13	0	0.098	0.28
214	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), SLC33A1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(3), ST8SIA5(2)	3317818	39	26	39	19	14	10	9	4	2	0	0.10	0.29
215	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(3), ADCY4(4), ADCY6(5), ADCY8(8), CACNA1A(9), CACNA1B(1), GNAS(12), GNAT3(2), GNB1(1), GNB3(1), GRM4(3), ITPR3(10), KCNB1(3), PDE1A(2), PLCB2(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1B(3), SCNN1G(4), TAS1R1(4), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(3), TAS2R4(1), TAS2R40(3), TAS2R41(1), TAS2R43(1), TAS2R50(1), TAS2R60(3), TAS2R7(1), TAS2R8(1), TAS2R9(1), TRPM5(1)	11551715	114	48	112	46	25	51	22	7	9	0	0.10	0.29
216	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(7), ITGAL(6), ITGB1(2), ITGB2(5), SELE(2), SELL(3)	2731554	30	22	30	15	7	9	3	5	6	0	0.10	0.29
217	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), AK3(3), CAD(4), CANT1(4), CDA(2), CTPS(2), CTPS2(1), DCTD(1), DHODH(1), DPYD(12), DPYS(1), DUT(1), ENTPD1(1), ENTPD3(2), ENTPD4(4), ENTPD6(1), NME6(1), NME7(1), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT2(1), PNPT1(3), POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1), PRIM1(1), PRIM2(3), RRM1(4), RRM2(1), RRM2B(1), TK1(2), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(2), UPP1(1), UPP2(3), UPRT(1)	16517004	137	52	137	42	25	52	28	11	21	0	0.10	0.30
218	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(4), EPHB2(10), F2(4), F2RL1(3), JUN(2), MAP2K5(1), MAPK1(2), MAPK7(8), MAPK8(4), MYEF2(3), PLD1(6), PLD2(10), PLD3(5), PTK2(5), RAF1(6), RASAL1(1), TEC(3), VAV1(2)	5612068	80	34	77	18	28	26	12	4	10	0	0.11	0.30
219	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(3), ANXA2(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(2), EDNRA(2), EDNRB(10), HSD11B1(1), HSD11B2(2), PLA2G4A(3), PRL(1), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2)	4223548	55	32	54	20	15	12	14	6	8	0	0.11	0.30
220	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(2), F12(2), F13B(8), F2(4), F5(8), F7(5), F8(9), F9(3), FGA(4), FGB(3), FGG(2), LPA(6), PLAT(2), PLAU(1), PLG(9), SERPINB2(2), SERPINE1(1), SERPINF2(3), VWF(8)	7083713	85	41	85	24	17	30	19	7	12	0	0.11	0.31
221	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(5), GRB2(1), INSR(7), IRS1(5), JAK2(4), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RPS6KA1(2), SHC1(3), SLC2A4(1), SOS1(3), SRF(1), STAT5B(4)	6676068	86	40	73	18	24	23	24	5	10	0	0.12	0.32
222	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CDK5(2), F2(4), FYN(3), GNA11(1), GNAI1(1), GNB1(1), GNGT1(2), GRB2(1), JAK2(4), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MAPT(4), MYLK(7), PLCG1(9), PTK2B(8), RAF1(6), SHC1(3), SOS1(3), STAT1(3), STAT3(4)	8455209	90	43	89	28	31	30	15	5	9	0	0.12	0.32
223	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CREBBP(11), EP300(10), ERCC3(3), ESR1(4), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(1), HDAC1(2), HDAC2(3), HDAC3(3), HDAC4(6), HDAC5(3), HDAC6(3), MEF2C(1), NCOR2(12), NR0B1(2), NRIP1(7), PELP1(5), POLR2A(6), TBP(2)	9580921	103	44	101	31	25	39	13	4	22	0	0.12	0.32
224	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(1), BIRC3(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(7), SREBF1(3), SREBF2(5)	3756452	35	28	35	11	7	11	7	5	5	0	0.12	0.32
225	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), CASP1(2), CASP3(1), CASP7(2), CASP8(3), GAPDH(1), INSR(7), ITCH(2), MAGI1(11), MAGI2(7), RERE(14), WWP1(6), WWP2(9)	4766188	69	31	68	16	15	11	13	9	21	0	0.12	0.34
226	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(3), HLA-DRA(2), HLA-DRB1(1), IL1B(1), IL6(1)	1075172	11	10	11	5	2	4	1	2	2	0	0.12	0.34
227	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), BAD(1), CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAMK2B(2), CAMK4(2), CD3E(1), CD3G(2), CDKN1A(1), CNR1(4), CREBBP(11), CSNK2A1(4), CTLA4(2), EGR2(3), EGR3(1), EP300(10), FCGR3A(1), GATA3(2), GATA4(2), GRLF1(8), GSK3B(1), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(1), IL1B(1), IL2(1), IL2RA(1), IL3(1), IL6(1), IL8(1), ITK(2), KPNA5(4), MAP2K7(8), MAPK14(1), MAPK8(4), MAPK9(1), MEF2B(2), MEF2D(3), MYF5(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB2(2), NFKBIB(3), NPPB(1), NUP214(8), OPRD1(1), PAK1(2), PIN1(1), PPP3CB(1), PTPRC(13), RELA(2), RPL13A(1), SP1(2), SP3(2), TGFB1(2), TNF(1), TRAF2(2), TRPV6(4), VAV1(2), VAV2(5), VAV3(6), XPO5(1)	18545919	199	57	198	81	55	58	43	16	27	0	0.12	0.34
228	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3)	2684871	37	23	36	4	6	11	8	6	6	0	0.13	0.34
229	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TGFBR3(1), TOB1(1), TOB2(4)	2148881	27	18	26	6	5	5	11	3	3	0	0.13	0.34
230	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(4), GSS(1), IL8(1), NFKB1(4), NOX1(4), RELA(2), TNF(1), XDH(8)	2021600	26	17	26	8	5	10	5	3	3	0	0.13	0.35
231	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(4), ABAT(2), ACY3(1), ADSL(4), ADSSL1(7), AGXT(1), AGXT2(4), ASL(4), ASNS(4), ASRGL1(1), ASS1(5), CAD(4), CRAT(1), DARS(1), DDO(2), DLAT(6), DLD(2), GAD1(3), GAD2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(4), PDHB(2)	7674100	81	41	80	31	20	37	14	6	4	0	0.13	0.35
232	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(3), EEF1D(4), EEF1G(2), EEF2K(6), EIF1AX(1), EIF1AY(1), EIF2AK1(3), EIF2AK2(2), EIF2AK3(6), EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(7), EIF4G3(5), EIF5(2), EIF5A(2), EIF5B(6), ETF1(2), GSPT2(1), KIAA0664(6), PABPC1(2), PABPC3(5), PAIP1(1), SLC35A4(3)	9010484	96	44	94	29	23	38	18	10	7	0	0.13	0.35
233	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(5), SNCAIP(5), UBE2F(2), UBE2G2(1), UBE2L6(1)	1286509	15	14	15	4	3	5	3	2	2	0	0.13	0.35
234	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), AKR1B1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CEL(6), DAK(2), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), GK(2), GK2(1), GLB1(2), GPAM(4), LCT(10), LIPA(1), LIPC(1), LIPF(1), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(2), PNLIPRP2(2), PNPLA3(1), PPAP2C(4)	11868654	114	47	113	37	20	45	23	12	14	0	0.14	0.37
235	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(3), HLA-DRA(2), HLA-DRB1(1)	485982	6	6	6	5	2	2	0	2	0	0	0.14	0.37
236	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(9)	1257914	17	13	16	4	3	6	3	0	3	2	0.14	0.38
237	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(1), AGTR1(1), AGTR2(1), ANPEP(3), CPA3(1), CTSG(2), ENPEP(6), LNPEP(9), MAS1(1), MME(2), NLN(5), REN(3), THOP1(5)	4290314	49	29	49	15	15	16	11	6	1	0	0.15	0.39
238	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(1), LIPA(1), RDH11(1), RDH12(1), SLC27A5(3), SOAT1(4), SOAT2(2), SRD5A1(2), SRD5A2(2)	6477233	75	34	74	17	14	29	13	9	10	0	0.15	0.39
239	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(3), CD80(1), HLA-DRA(2), HLA-DRB1(1), IL10(1), IL2(1)	805182	9	9	9	5	2	3	2	2	0	0	0.16	0.40
240	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(4), ABCA10(7), ABCA12(17), ABCA13(19), ABCA2(6), ABCA3(10), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(3), ABCA8(5), ABCA9(8), ABCB1(8), ABCB10(5), ABCB11(4), ABCB4(10), ABCB5(2), ABCB6(2), ABCB8(4), ABCB9(2), ABCC1(4), ABCC10(3), ABCC11(9), ABCC12(7), ABCC2(11), ABCC3(4), ABCC4(4), ABCC5(8), ABCC6(6), ABCC8(6), ABCC9(20), ABCD1(2), ABCD2(4), ABCD3(1), ABCD4(3), ABCG1(2), ABCG2(3), ABCG4(3), ABCG8(4), CFTR(2), TAP1(2), TAP2(5)	24248826	245	68	240	88	67	70	64	10	34	0	0.16	0.40
241	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(5), XYLT2(3)	1412726	21	15	21	6	5	6	7	0	3	0	0.16	0.40
242	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(5), XYLT2(3)	1412726	21	15	21	6	5	6	7	0	3	0	0.16	0.40
243	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(1), GCLM(2), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), MGST3(1), PGD(1)	3697001	37	26	36	9	7	12	13	4	1	0	0.16	0.40
244	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR0B2(1), NR1H4(2), RXRA(2)	1094191	10	10	10	7	2	4	0	3	1	0	0.16	0.40
245	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(2), GPI(4), HK1(5), PFKL(6), PGK1(1), PKLR(4), TPI1(1)	1779673	27	20	27	10	10	14	3	0	0	0	0.16	0.40
246	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(2), ALOX15B(1), ALOX5(2), GGT1(7), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2)	3096772	33	25	32	9	9	12	6	5	1	0	0.16	0.40
247	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3E(1), CD3G(2), CD4(3)	504735	6	6	5	5	0	2	1	1	2	0	0.16	0.40
248	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(3), IL1R1(2), IRAK1(4), MAP3K1(5), MAP3K14(1), MAP3K7(7), MYD88(2), NFKB1(4), RELA(2), TLR4(9), TNF(1), TNFAIP3(4), TNFRSF1A(3), TRAF6(3)	5009046	50	32	48	13	6	22	15	1	6	0	0.17	0.41
249	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), COASY(1), DPYD(12), DPYS(1), ENPP1(1), ENPP3(3), PANK1(1), PANK2(2), PANK4(2), UPB1(2)	2845668	27	20	27	4	4	7	10	2	4	0	0.17	0.41
250	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(5), JAK2(4), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(10), REG1A(4), SOAT1(4)	2861362	36	23	36	11	7	17	4	2	4	2	0.17	0.42
251	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), F10(3), F11(2), F12(2), F2(4), F2R(2), F5(8), F8(9), F9(3), FGA(4), FGB(3), FGG(2), KLKB1(4), PROC(2), SERPINC1(2), SERPING1(5)	9021124	78	43	78	29	19	23	18	8	10	0	0.17	0.43
252	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(4), CANT1(4), CDA(2), CTPS(2), CTPS2(1), DCTD(1), DHODH(1), DPYD(12), DPYS(1), DUT(1), ENTPD1(1), NUDT2(1), POLD1(4), POLG(1), POLL(1), POLQ(11), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8), RRM1(4), RRM2(1), TK1(2), TK2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(1)	11716502	93	43	93	33	15	37	22	6	13	0	0.17	0.43
253	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(2), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(2), CBR1(1), CBR3(1), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2J2(2), CYP2U1(2), CYP4A22(1), CYP4F2(1), CYP4F3(3), DHRS4(1), EPHX2(4), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GPX6(1), GPX7(2), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2)	7949277	90	41	88	19	24	34	17	9	6	0	0.18	0.43
254	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3)	1609300	21	17	21	4	6	9	4	0	2	0	0.18	0.43
255	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3)	1609300	21	17	21	4	6	9	4	0	2	0	0.18	0.43
256	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(3), ALG1(2), ALG10(3), ALG10B(1), ALG13(1), ALG3(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT5(2), B4GALT7(1), C1GALT1(1), C1GALT1C1(3), CHPF(2), CHST1(8), CHST11(1), CHST12(5), CHST13(1), CHST2(6), CHST3(1), CHST6(4), CHST7(1), EXT1(7), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), FUT11(1), FUT8(2), GALNT1(2), GALNT10(3), GALNT11(3), GALNT12(1), GALNT13(3), GALNT14(5), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT8(3), GALNTL1(2), GALNTL2(4), GALNTL4(4), GALNTL5(4), GANAB(2), GCNT1(1), GCNT3(2), GCNT4(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(2), HS6ST1(2), HS6ST2(1), HS6ST3(3), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(6), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(2), NDST1(8), NDST2(5), NDST3(3), NDST4(7), OGT(2), RPN1(1), RPN2(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1), ST6GALNAC1(1), STT3B(4), UST(3), WBSCR17(7), XYLT1(5), XYLT2(3)	22628753	240	66	238	97	60	92	58	9	21	0	0.18	0.43
257	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(4), GLUD1(3), GLUD2(3)	857318	14	10	14	4	2	7	3	1	1	0	0.18	0.44
258	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(1), AKT3(3), CISH(2), GRB2(1), IARS(6), IL13RA1(1), IL2RG(2), INPP5D(1), JAK1(5), JAK2(4), JAK3(3), NR0B2(1), PI3(2), PIK3CA(23), PPP1R13B(3), RPS6KB1(2), SERPINA4(1), SHC1(3), SOS1(3), SOS2(4), TYK2(4)	7518224	77	39	64	27	21	21	18	6	9	2	0.18	0.44
259	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(4), FADS2(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3)	2063628	26	20	26	5	8	12	5	0	1	0	0.20	0.48
260	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CDK2(2), CUL1(5), FBXW7(8), RB1(6)	1717030	22	17	19	2	3	7	6	2	4	0	0.20	0.48
261	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(9), ADRB2(2), GNAS(12), PLCE1(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	2960447	42	25	41	18	12	19	4	4	3	0	0.20	0.48
262	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADK(1), ADSL(4), ADSSL1(7), AK5(2), AK7(2), ALLC(2), AMPD1(2), AMPD2(5), AMPD3(5), ATIC(3), CANT1(4), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(1), ENTPD3(2), ENTPD4(4), ENTPD6(1), FHIT(1), GART(4), GDA(1), GMPR(2), GMPS(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), GUK1(2), IMPDH1(1), NME6(1), NME7(1), NPR1(6), NPR2(2), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(4), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(2), PDE2A(6), PDE3B(9), PDE4A(4), PDE4B(4), PDE4C(2), PDE5A(5), PDE7A(5), PDE7B(2), PDE8A(5), PDE8B(2), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), PNPT1(3), POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(3), PRUNE(2), RRM1(4), RRM2(1), RRM2B(1), XDH(8)	33403615	315	76	314	119	81	107	76	29	22	0	0.21	0.51
263	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(4), ESR2(5), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(8), PLCB2(3), PRL(1), TRH(1)	2273236	26	18	25	9	4	12	5	0	5	0	0.22	0.51
264	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(10), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAR2A(1), PRKAR2B(5)	2038757	22	16	22	7	3	10	4	3	2	0	0.22	0.51
265	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), EGR1(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(2), RAF1(6)	1696149	20	16	20	12	4	10	3	2	1	0	0.22	0.51
266	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(1), CHKA(1), PCYT1A(6), PDHA1(1), PDHA2(4), PEMT(1)	1439592	17	15	17	5	6	7	3	1	0	0	0.22	0.51
267	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(6), ADC(1), AGMAT(2), ALDH18A1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ASL(4), ASS1(5), CPS1(8), GATM(1), MAOA(1), MAOB(2), NAGS(1), ODC1(3), OTC(1), SMS(2), SRM(1)	6001359	64	36	64	14	14	24	17	4	3	2	0.22	0.51
268	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADL(1), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(4), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADIPOQ(2), ANGPTL4(1), APOA5(4), AQP7(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(3), CYP27A1(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(1), FABP2(1), FABP3(1), FABP5(1), FABP6(2), FABP7(1), FADS2(4), GK(2), GK2(1), HMGCS2(1), LPL(1), ME1(3), MMP1(1), OLR1(2), PCK1(3), PCK2(4), PDPK1(1), PLTP(2), PPARA(2), PPARD(4), PPARG(1), RXRA(2), RXRG(2), SCD(4), SCP2(2), SLC27A1(1), SLC27A4(3), SLC27A5(3), SLC27A6(4), SORBS1(5), UBC(3)	13074432	119	49	119	29	31	47	18	10	13	0	0.22	0.51
269	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(2)	226898	3	3	2	1	0	0	1	0	2	0	0.22	0.51
270	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), DHRS7(1), ESCO2(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1)	4903178	49	29	48	8	6	11	14	10	8	0	0.22	0.51
271	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(3), ATIC(3), GART(4), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(4), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	3599911	36	25	36	12	9	10	8	4	5	0	0.23	0.52
272	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DDC(3), HARS(4), HDC(3), HNMT(1), MAOA(1), MAOB(2), PRPS1(1), PRPS2(3)	4913153	55	31	54	13	12	20	12	6	3	2	0.23	0.53
273	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), NR3C1(3), PPARG(1), RXRA(2), TNF(1)	1163617	9	9	9	2	2	2	3	1	1	0	0.24	0.55
274	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(6), ITGAM(4), ITGB2(5), SELE(2), SELL(3)	2416211	25	19	25	16	8	8	2	2	5	0	0.25	0.55
275	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(7), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(1), SEPHS1(1)	2517690	26	19	25	9	5	8	6	4	3	0	0.25	0.55
276	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ADAM17(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), CASP3(1), CCL5(1), CDC42(1), CSK(2), EGFR(7), GIT1(2), IGSF5(1), IKBKB(3), IL8(1), JAM3(2), JUN(2), LYN(2), MAP2K4(5), MAP3K14(1), MAPK10(3), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(1), MET(3), NFKB1(4), NFKB2(2), NOD1(6), PAK1(2), PLCG1(9), PLCG2(5), PTPN11(3), PTPRZ1(13), RELA(2), TCIRG1(2), TJP1(4)	14264516	130	51	129	52	31	45	28	9	17	0	0.25	0.56
277	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(8), ACSS1(6), ACSS2(2), FH(1), IDH1(1), IDH2(1), MDH1(1), SUCLA2(3)	2654281	25	19	24	9	4	11	5	1	4	0	0.26	0.58
278	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(4), CREBBP(11), EP300(10), NCOA3(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RARA(1), RXRA(2)	4085494	48	27	48	17	13	15	4	6	10	0	0.26	0.58
279	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(1), AKT3(3), BAD(1), BCR(4), BLNK(1), BTK(1), CD81(2), CR2(3), CSK(2), DAG1(7), FLOT1(1), FLOT2(3), GRB2(1), GSK3B(1), INPP5D(1), ITPR1(13), ITPR2(12), ITPR3(10), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(5), NR0B2(1), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PLCG2(5), PPP1R13B(3), PPP3CA(2), PPP3CB(1), PTPRC(13), RAF1(6), SHC1(3), SOS1(3), SOS2(4), SYK(1), VAV1(2)	15072491	160	55	147	63	40	48	42	11	19	0	0.26	0.58
280	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(2), ALDH5A1(3), CAD(4), CPS1(8), EPRS(3), GAD1(3), GAD2(3), GCLM(2), GFPT1(3), GLS(4), GLS2(4), GLUD1(3), GLUL(2), GMPS(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), GSS(1), NADSYN1(3), PPAT(1), QARS(4)	6643217	66	36	65	28	21	22	14	5	4	0	0.27	0.59
281	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(1), GCLM(2), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GPX6(1), GPX7(2), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(1)	4547935	49	28	48	11	11	18	12	5	3	0	0.28	0.61
282	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(5), PTPRU(10), REG1A(4), STAT1(3), STAT2(1), TYK2(4)	2528064	31	20	31	10	3	16	6	1	3	2	0.28	0.61
283	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), CBL(1), GRB2(1), IL2RA(1), IL2RG(2), IRS1(5), JAK1(5), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3CA(23), PIK3R1(5), RAF1(6), RPS6KB1(2), SHC1(3), SOCS3(2), SOS1(3), STAT5B(4), SYK(1)	7378308	74	38	61	26	21	16	20	4	11	2	0.28	0.61
284	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), ELK1(2), IKBKB(3), IRAK1(4), JUN(2), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(4), PPARA(2), RELA(2), TIRAP(1), TLR10(1), TLR2(2), TLR3(1), TLR4(9), TLR7(3), TLR9(7), TOLLIP(1), TRAF6(3)	7403977	77	38	74	26	11	33	19	3	11	0	0.28	0.61
285	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(9), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(12), GNB1(1), GNGT1(2), JUN(2), MAP2K1(3), MAPK3(1), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RAF1(6)	7049399	89	39	87	24	28	34	14	4	9	0	0.29	0.63
286	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(6), AOC2(4), AOC3(2), CES1(5), CES7(5), DDHD1(5), ESCO2(1), LIPA(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(1)	5117574	53	31	52	16	14	18	12	4	3	2	0.29	0.63
287	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ASL(4), ASS1(5), CKMT1A(1), CKMT2(2), CPS1(8), DAO(3), EPRS(3), GATM(1), GLUD1(3), GLUD2(3), GOT1(2), GOT2(2), LAP3(1), NOS1(15), NOS3(2), OTC(1), P4HA2(6), P4HA3(1), PYCRL(1), RARS(2), RARS2(1)	7258342	70	36	69	23	21	23	17	2	7	0	0.29	0.63
288	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(6), AGMAT(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH4A1(2), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ASL(4), CKMT1A(1), CKMT2(2), CPS1(8), DAO(3), GATM(1), GLUD1(3), GOT1(2), GOT2(2), MAOA(1), MAOB(2), NOS1(15), NOS3(2), ODC1(3), OTC(1), P4HA2(6), P4HA3(1), P4HB(1), RARS(2), SMS(2)	8899296	102	42	101	24	31	32	22	6	9	2	0.29	0.63
289	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(5), CBS(3), CTH(2), DNMT1(10), DNMT3A(5), DNMT3B(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(4)	3536470	39	23	39	26	5	21	7	3	3	0	0.29	0.63
290	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(9), CCNB1(1), CDC25C(2), GNAI1(1), GNAS(12), GNB1(1), GNGT1(2), MAPK1(2), MAPK3(1), PIN1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RPS6KA1(2)	4121138	47	27	46	21	10	23	5	4	5	0	0.30	0.63
291	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(4), ABCB4(10), ABCC1(4), ABCC3(4), GSTP1(1)	2906715	31	21	31	12	11	4	9	1	6	0	0.30	0.64
292	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), GNAI1(1), GNB1(1), GNGT1(2), ITGA1(4), ITGB1(2), MAP2K1(3), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(8), PTGS1(4), PTK2(5), RAF1(6), SYK(1), TBXAS1(2)	4933901	51	30	51	20	9	17	14	3	8	0	0.30	0.64
293	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(3), ATIC(3), GART(4), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(4), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	3824947	36	25	36	12	9	10	8	4	5	0	0.31	0.65
294	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(11), ACTN3(1), BCAR1(3), BCR(4), CAPN1(1), CAPNS1(1), CAV1(2), CSK(2), FYN(3), GRB2(1), ITGA1(4), ITGB1(2), JUN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(4), PPP1R12B(2), PTK2(5), PXN(2), RAF1(6), RAP1A(1), ROCK1(5), SHC1(3), SOS1(3), TLN1(9), VCL(2), ZYX(2)	9668967	91	44	91	40	29	29	17	8	8	0	0.31	0.65
295	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(3)	432915	5	5	5	0	1	1	1	0	2	0	0.31	0.65
296	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(7), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(2), SH3GLB1(1), SH3GLB2(2), SH3KBP1(4)	3896501	32	21	32	25	4	15	2	3	8	0	0.31	0.65
297	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(4), CANX(1), CD4(3), CD74(1), CD8A(1), CIITA(6), CREB1(4), CTSL1(2), HLA-A(8), HLA-B(10), HLA-C(4), HLA-DMA(1), HLA-DMB(2), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DRA(2), HLA-DRB1(1), HLA-E(3), HLA-F(4), HSP90AA1(1), HSP90AB1(2), IFI30(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), KIR2DL1(3), KIR2DL3(1), KIR2DL4(3), KIR2DS4(2), KIR3DL1(1), KLRC1(1), KLRC2(1), KLRD1(1), LGMN(2), LTA(1), PDIA3(1), PSME2(2), RFX5(3), RFXANK(1), TAP1(2), TAP2(5), TAPBP(3)	9487688	112	41	109	35	20	27	30	10	21	4	0.32	0.65
298	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F1(1), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2IRD1(7), TAF1(4), TAF10(1), TAF1L(10), TAF2(3), TAF4(2), TAF4B(2), TAF5(2), TAF5L(4), TAF6(6), TAF7(4), TAF7L(3), TBPL2(2)	7255549	65	32	64	17	23	20	7	6	9	0	0.32	0.65
299	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(5), BMP5(5), BMP6(4), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1L(1), CSNK1E(5), CSNK1G1(2), CSNK1G2(2), CSNK1G3(4), DHH(2), FBXW11(4), GLI1(9), GLI2(5), GLI3(11), GSK3B(1), HHIP(3), IHH(1), LRP2(32), PRKACA(1), PRKACB(2), PRKACG(2), PRKX(1), PTCH1(9), PTCH2(4), SMO(6), STK36(6), SUFU(3), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2)	12560254	168	52	165	56	50	62	23	9	24	0	0.32	0.65
300	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(9), ADRB2(2), CFTR(2), GNAS(12), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	2591904	37	22	36	12	11	16	4	4	2	0	0.32	0.65
301	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(2), BAG4(1), BID(1), BIRC2(1), BIRC3(3), CASP2(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DAXX(3), DFFA(2), DFFB(2), GSN(4), LMNA(2), LMNB1(1), LMNB2(3), MAP2K7(8), MAP3K1(5), MAP3K14(1), MAPK8(4), MDM2(2), NFKB1(4), NUMA1(10), PAK2(3), PRKCD(2), PRKDC(18), PSEN1(1), PSEN2(1), PTK2(5), RASA1(10), RB1(6), RELA(2), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(2)	14308273	131	48	129	42	23	49	27	8	22	2	0.32	0.65
302	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(9), PTK2B(8)	1359526	17	14	16	6	7	7	2	0	1	0	0.32	0.66
303	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(1), JAK1(5), JAK2(4), JAK3(3), PIAS3(1), PTPRU(10), REG1A(4), STAT3(4)	3159814	34	22	34	12	7	17	5	2	1	2	0.33	0.66
304	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(5), JAK2(4), PTPRU(10), REG1A(4), STAT1(3)	2319121	32	18	32	9	4	17	5	2	2	2	0.33	0.66
305	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3)	2570624	33	21	33	9	9	12	7	2	3	0	0.33	0.67
306	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(4)	1260707	14	12	14	5	2	4	4	1	1	2	0.33	0.67
307	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(2), GPR161(2), GPR39(5), GPR45(3), GPR68(4), GPR75(3)	1974252	21	16	21	8	7	4	7	2	1	0	0.34	0.69
308	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), PAK1(2), PLCG1(9), PTK2B(8), RAF1(6), SHC1(3), SOS1(3)	5824070	65	34	64	21	18	24	12	4	7	0	0.35	0.69
309	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(2), GOSR1(1), GOSR2(2), SNAP25(1), SNAP29(3), STX10(1), STX11(1), STX16(3), STX18(1), STX4(1), STX5(1), STX6(3), STX7(1), STX8(1), TSNARE1(5), USE1(2), VAMP4(1), VAMP5(1), VTI1B(1)	3308375	32	23	32	10	11	14	2	3	2	0	0.35	0.69
310	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(1)	401394	5	5	5	2	2	1	1	1	0	0	0.35	0.69
311	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(16), ASH2L(3), C17orf79(2), CARM1(1), CTCFL(1), DOT1L(8), EED(2), EHMT2(2), EZH1(1), EZH2(2), FBXO11(5), HCFC1(11), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(5), MEN1(2), MLL(9), MLL2(27), MLL3(23), MLL4(20), MLL5(9), NSD1(9), OGT(2), PAXIP1(2), PPP1CA(2), PPP1CB(1), PPP1CC(2), PRDM2(15), PRDM9(5), PRMT1(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(7), SETD1A(7), SETD2(4), SETDB1(11), SETDB2(4), SMYD3(2), SUV39H1(4), SUV39H2(1), SUV420H1(3), SUV420H2(1), SUZ12(3), WHSC1(5), WHSC1L1(6)	24537835	259	63	253	81	49	88	38	23	50	11	0.35	0.69
312	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), FUT1(1), FUT9(1), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(3)	2176944	19	17	19	7	8	4	4	2	1	0	0.35	0.69
313	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(11), DFFA(2), DFFB(2), GZMA(1), HMGB2(2), PRF1(1), SET(1)	2137044	21	18	21	9	4	6	5	2	4	0	0.35	0.69
314	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), JUN(2), MAPK3(1), OPRK1(3), POLR2A(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	2528862	28	20	28	9	7	13	2	3	3	0	0.36	0.70
315	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP3(1), CASP7(2), CASP8(3), DAXX(3), DFFA(2), DFFB(2), FAF1(3), JUN(2), LMNA(2), LMNB1(1), LMNB2(3), MAP2K4(5), MAP3K1(5), MAP3K7(7), MAPK8(4), PAK1(2), PAK2(3), PRKDC(18), PTPN13(10), RB1(6), RIPK2(1), SPTAN1(8)	8617336	95	41	94	31	13	35	21	8	18	0	0.36	0.70
316	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(4), ASRGL1(1), CA1(1), CA13(1), CA14(1), CA3(1), CA4(2), CA5B(1), CA6(2), CA7(1), CA9(2), CPS1(8), CTH(2), GLS(4), GLS2(4), GLUD1(3), GLUD2(3), GLUL(2)	4214238	46	26	46	14	4	22	11	4	5	0	0.36	0.71
317	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASS(1), ACAT1(2), ACAT2(1), AKR1B10(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BBOX1(1), DOT1L(8), EHHADH(1), EHMT2(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(9), OGDH(7), OGDHL(3), PIPOX(2), PLOD1(5), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(7), SETDB1(11), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(3)	11834739	107	46	104	32	23	33	22	13	16	0	0.36	0.71
318	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), MEF2B(2), MEF2C(1), MEF2D(3), PAK1(2), PTK2(5), PTK2B(8), RAF1(6), SHC1(3), SOS1(3)	6817181	73	36	73	24	17	28	17	3	8	0	0.37	0.71
319	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(11), EP300(10), ESR1(4), MAPK1(2), MAPK3(1), PELP1(5)	3018169	33	20	32	6	8	10	3	1	11	0	0.37	0.71
320	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3)	3617068	45	24	44	11	9	16	9	4	5	2	0.37	0.71
321	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(7), MAP2K1(3), MAP3K1(5), MAPK14(1), NCOR2(12), RARA(1), RXRA(2), THRA(1), THRB(4)	3581158	40	25	40	19	9	18	7	1	5	0	0.37	0.72
322	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ADC(1), ALDH4A1(2), ALDH5A1(3), CAD(4), CPS1(8), EARS2(2), EPRS(3), GAD1(3), GAD2(3), GCLM(2), GFPT1(3), GFPT2(1), GLS(4), GLS2(4), GLUD1(3), GLUD2(3), GLUL(2), GMPS(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), GSR(4), GSS(1), NADSYN1(3), PPAT(1), QARS(4)	7931455	77	39	76	31	23	27	17	6	4	0	0.38	0.72
323	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(1), GCNT2(2), ST3GAL6(2), ST8SIA1(3)	3322606	28	23	27	11	6	11	7	3	1	0	0.38	0.73
324	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(5), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(4), TYK2(4)	2438023	23	18	23	10	6	9	2	1	3	2	0.38	0.73
325	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(2), AKT2(1), AKT3(3), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(2), PLD1(6), PLD2(10), PLD3(5), VN1R1(3)	9210782	107	41	107	37	21	44	20	10	10	2	0.39	0.73
326	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(3), CTH(2), GGT1(7), LCMT1(1), LCMT2(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), METTL6(1), PAPSS1(4), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(1), WBSCR22(1)	5052404	44	29	43	16	10	12	9	5	8	0	0.39	0.74
327	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(14), ACACB(11), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(6), ACSS2(2), ACYP2(1), AKR1B1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(4), ME3(4), PC(3), PCK1(3), PCK2(4), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	9396184	109	43	109	30	24	42	22	7	14	0	0.39	0.74
328	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(6), ACY3(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), AOC2(4), AOC3(2), CARM1(1), CNDP1(1), DDC(3), HARS(4), HARS2(2), HDC(3), HNMT(1), LCMT1(1), LCMT2(4), MAOA(1), MAOB(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(1)	8006999	69	37	68	17	16	23	15	7	6	2	0.40	0.75
329	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP2(2), CASP3(1), CASP8(3), DFFA(2), DFFB(2), JUN(2), LMNA(2), LMNB1(1), LMNB2(3), MADD(3), MAP2K4(5), MAP3K1(5), MAP3K7(7), MAPK8(4), PAK1(2), PAK2(3), PRKDC(18), RB1(6), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(2)	8117389	86	40	85	30	14	36	17	5	14	0	0.40	0.75
330	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(3), CYCS(1), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), NFKB1(4), NSMAF(6), RAF1(6), RELA(2), SMPD1(3), TNFRSF1A(3), TRAF2(2)	4206790	51	27	51	17	13	18	7	4	9	0	0.40	0.75
331	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(2), AMPD2(5), AMPD3(5), ATIC(3), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), CANT1(4), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(1), FHIT(1), GART(4), GDA(1), GMPS(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), GUK1(2), IMPDH1(1), NPR1(6), NPR2(2), NUDT2(1), PAPSS1(4), PAPSS2(2), PDE1A(2), PDE4A(4), PDE4B(4), PDE4C(2), PDE5A(5), PDE6B(7), PDE6C(2), PDE7B(2), PDE8A(5), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), POLD1(4), POLG(1), POLL(1), POLQ(11), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8), PPAT(1), PRPS1(1), PRPS1L1(1), PRPS2(3), PRUNE(2), RRM1(4), RRM2(1)	26283992	242	66	241	97	65	78	63	21	15	0	0.40	0.75
332	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2A(1), AMY2B(2), ENPP1(1), ENPP3(3), GAA(2), GANAB(2), GBA3(1), GBE1(3), GCK(2), GPI(4), GUSB(1), GYS1(4), GYS2(2), HK1(5), HK2(3), HK3(2), MGAM(4), PGM1(2), PGM3(5), PYGB(4), PYGL(4), PYGM(6), SI(9), UCHL1(1), UCHL3(3), UGDH(1), UGT1A5(1), UGT2B15(1), UGT2B4(2), UXS1(1)	11359929	89	43	89	34	22	27	21	5	14	0	0.40	0.75
333	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAD(1), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CD40(1), CD40LG(3), CYCS(1), DAXX(3), DFFA(2), DFFB(2), FAS(1), IKBKE(2), LTA(1), NFKB1(4), NGFR(2), NR3C1(3), NTRK1(3), PTPN13(10), SFRS2IP(4), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF3(2), TRAF6(3)	9025646	71	38	71	34	17	21	17	8	8	0	0.40	0.75
334	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1C1(1), AKR1C3(1), AKR1C4(1), ALDH3A1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2F1(1), CYP2S1(3), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHDH(4), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2)	11138750	102	42	101	29	22	31	23	14	12	0	0.41	0.75
335	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT9(1), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), ST8SIA1(3)	2053653	18	16	18	6	9	4	3	1	1	0	0.41	0.75
336	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(2), KNG1(2), NOS3(2), REN(3)	2067086	16	14	16	9	3	6	3	1	3	0	0.42	0.76
337	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), COASY(1), DPYD(12), DPYS(1), ENPP1(1), ENPP3(3), ILVBL(2), PANK1(1), PANK2(2), PANK4(2), PPCDC(1), UPB1(2), VNN1(1)	3535672	32	20	32	4	7	8	10	3	4	0	0.42	0.76
338	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1)	3032267	30	21	30	10	7	9	9	3	2	0	0.42	0.76
339	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1)	3032267	30	21	30	10	7	9	9	3	2	0	0.42	0.76
340	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1)	3032267	30	21	30	10	7	9	9	3	2	0	0.42	0.76
341	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(3), SNAP25(1), STX1A(1)	649705	6	6	6	3	4	0	2	0	0	0	0.42	0.76
342	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), GOT2(2), TAT(1), TYR(1)	938049	9	9	9	3	3	5	0	1	0	0	0.42	0.76
343	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), BHMT(5), CBS(3), CTH(2), DNMT1(10), DNMT3A(5), DNMT3B(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(4), SRM(1), TAT(1)	4214637	43	25	43	29	6	22	8	4	3	0	0.43	0.77
344	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(11), ACTN3(1), CAPN1(1), CAPNS1(1), ITGA1(4), ITGB1(2), ITGB3(5), PTK2(5), PXN(2), SPTAN1(8), TLN1(9)	5816489	52	31	52	29	16	17	9	5	5	0	0.43	0.78
345	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), NFS1(2), PHPT1(3), THTPA(1), TPK1(2)	1285977	17	12	17	2	6	3	6	1	1	0	0.43	0.78
346	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(2), GSTZ1(1)	263872	3	3	3	0	0	3	0	0	0	0	0.44	0.78
347	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(4), ALDOC(2), TPI1(1)	774725	8	8	8	2	2	5	1	0	0	0	0.44	0.78
348	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), ELK1(2), FPR1(1), GNA15(2), GNB1(1), GNGT1(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(1), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), PAK1(2), PIK3C2G(3), PLCB1(8), PPP3CA(2), PPP3CB(1), RAF1(6), RELA(2)	7873866	78	37	78	25	16	26	17	7	12	0	0.44	0.79
349	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CAMKK1(2), CREB1(4)	2374183	22	16	22	8	4	9	4	2	3	0	0.45	0.79
350	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), DAB1(4), FYN(3), LRP8(1), RELN(15), VLDLR(3)	2806034	28	19	28	17	12	6	4	2	4	0	0.45	0.79
351	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	DAXX(3), EGF(4), EGFR(7), ETS1(3), ETS2(1), HOXA7(2), IKBKB(3), JUN(2), MAP2K1(3), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K14(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), NFKB1(4), PPP2CA(1), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), RAF1(6), RELA(2), SP1(2), TNF(1), TNFRSF1A(3), TRAF2(2)	10037643	92	41	91	41	19	43	11	5	14	0	0.45	0.80
352	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1)	1362851	12	11	12	4	1	3	4	2	2	0	0.46	0.80
353	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(2), ADSL(4), AGXT(1), AGXT2(4), ASL(4), ASNS(4), CAD(4), CRAT(1), DARS(1), DDO(2), GAD1(3), GAD2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), NARS(1), PC(3)	5272652	47	29	46	21	13	21	7	5	1	0	0.46	0.80
354	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), IL6(1), LDLR(3), LPL(1)	1064399	7	7	7	3	1	0	1	2	3	0	0.46	0.80
355	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(2), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(4), PLCB1(8), RAF1(6), RELA(2), TNF(1)	3131618	30	21	30	10	5	11	7	2	5	0	0.46	0.80
356	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(2), IL1RAP(3), IL6(1), IRAK1(4), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(4), RELA(2), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(3)	6023304	68	32	67	22	15	26	15	4	8	0	0.47	0.80
357	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(4), BCMO1(1), RDH5(1)	775124	9	8	9	5	4	3	1	0	1	0	0.47	0.80
358	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(3), CTH(2), MUT(3)	996702	9	9	9	7	0	3	2	1	3	0	0.47	0.80
359	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(1), MDH1(1), OGDH(7), SDHA(4), SUCLA2(3)	1880753	17	14	16	6	3	6	3	1	4	0	0.47	0.80
360	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(4), CA1(1), CA14(1), CA3(1), CA4(2), CA5B(1), CA6(2), CA7(1), CA9(2), CPS1(8), CTH(2), GLS(4), GLS2(4), GLUD1(3), GLUL(2)	3755521	41	23	41	13	4	18	10	4	5	0	0.47	0.80
361	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCR1(1), CCR2(1), CCR3(3), CD4(3), CXCR4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), IL2(1), TGFB1(2), TGFB2(4), TGFB3(3)	3811514	34	21	34	17	4	12	10	2	6	0	0.47	0.80
362	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CDC34(1), CDK2(2), CUL1(5), RB1(6), SKP2(2)	1762383	18	14	17	3	1	5	8	2	2	0	0.47	0.80
363	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(14), ACAT1(2), ACAT2(1), ACYP2(1), ADH5(1), AKR1B1(3), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(4), ME3(4), PC(3), PCK1(3), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	7432705	90	38	90	24	17	35	21	6	11	0	0.48	0.81
364	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(1), CCND2(1), CCND3(2), CCNH(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CDKN2D(1), RB1(6), RBL1(3)	3209955	29	21	28	9	7	10	8	1	3	0	0.48	0.81
365	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(11), EP300(10), LPL(1), NCOA1(7), NCOA2(10), PPARG(1), RXRA(2)	3710833	42	23	42	10	13	12	6	2	9	0	0.48	0.81
366	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(2), CSK(2), GRB2(1), PTPRA(4)	1870113	16	14	16	3	2	6	4	0	4	0	0.49	0.82
367	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(3), CD8A(1), CSF3(1), IL11(1), IL2(1), IL3(1), IL6(1), IL8(1)	1268554	10	9	10	6	1	5	2	1	1	0	0.49	0.83
368	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(2), NDUFA1(1), SDHA(4), SDHB(3), SDHC(1), UQCRC1(2)	1319626	15	12	15	4	5	5	3	0	2	0	0.49	0.83
369	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(6), LARS(2), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2)	2008566	18	16	18	5	1	9	5	0	3	0	0.50	0.83
370	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(3), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(5), STAT1(3), STAT3(4), TNF(1)	2455180	22	16	22	6	4	10	3	2	1	2	0.50	0.84
371	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(6), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(3), COX4I1(3), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA8(1), NDUFA9(2), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFC2(2), NDUFS1(4), NDUFS2(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), PPA2(1), SDHA(4), SDHB(3), SDHC(1), TCIRG1(2), UQCRB(1), UQCRC1(2), UQCRC2(1), UQCRQ(1)	11292764	102	43	102	46	29	30	27	8	8	0	0.50	0.84
372	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C8B(4), C9(3), MASP1(3)	4273157	52	26	51	11	11	18	11	4	6	2	0.51	0.84
373	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(2), TAT(1)	525084	5	5	5	3	1	4	0	0	0	0	0.51	0.85
374	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(1), DLG4(4), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), NOS1(15), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	5138854	60	32	60	20	23	20	6	4	7	0	0.51	0.85
375	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(1), GNA12(1), GNAQ(1), GNB1(1), GNGT1(2), MYL2(1), MYLK(7), PLCB1(8), PPP1R12B(2), ROCK1(5)	4161836	35	24	35	20	8	10	6	1	8	2	0.52	0.85
376	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(8), DLD(2), FH(1), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(3), PC(3), PCK1(3), PCK2(4), SDHA(4), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(3)	5987261	56	31	54	22	10	24	10	4	8	0	0.52	0.85
377	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3), MASP1(3), MASP2(2), MBL2(1)	4382217	51	25	50	12	11	19	10	4	5	2	0.52	0.85
378	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(11), DUSP1(1), EP300(10), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(2), MAP3K14(1), MAP3K7(7), MAPK14(1), MYD88(2), NFKB1(4), NR3C1(3), RELA(2), TGFBR1(1), TGFBR2(4), TLR2(2), TNF(1)	6029555	58	30	58	15	14	15	12	5	12	0	0.52	0.85
379	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(2), DPM1(1), FUT8(2), MAN1B1(1), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), RPN1(1), RPN2(2)	4038944	32	24	31	19	9	10	8	1	4	0	0.53	0.85
380	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), FH(1), IDH1(1), IDH2(1), MDH1(1), SDHB(3), SUCLA2(3)	1777412	18	13	17	3	1	11	3	1	2	0	0.53	0.85
381	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHRS7(1), PON2(2)	3534608	34	22	33	13	8	13	3	4	6	0	0.53	0.85
382	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12B(1), IL2(1)	599963	6	6	6	1	1	1	4	0	0	0	0.53	0.85
383	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(1), LCMT2(4), METTL6(1), PCYT1A(6), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(1)	2862692	24	19	24	7	7	7	5	1	4	0	0.53	0.85
384	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K11(3), MAP3K12(3), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K6(5), MAP3K7(7), MAP3K9(3), MAP4K1(2), MAP4K2(3), MAP4K3(2), MAP4K4(4), MAP4K5(4), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(3), MAPK6(1), MAPK7(8), MAPK8(4), MAPK9(1), MAPKAPK3(3), MAPKAPK5(1), MEF2B(2), MEF2C(1), MEF2D(3), MKNK1(1), NFKB1(4), PAK1(2), PAK2(3), RAF1(6), RELA(2), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TRAF2(2)	19867274	185	51	183	64	45	72	27	12	29	0	0.53	0.85
385	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(3)	1196335	12	10	12	3	6	3	2	0	1	0	0.53	0.85
386	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), UGDH(1)	1731660	15	14	15	1	4	6	4	0	1	0	0.54	0.85
387	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(3), TNF(1), TNFRSF1A(3), TRAF2(2)	1753073	13	12	13	4	5	3	2	1	2	0	0.54	0.86
388	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(15), B3GALT4(1), CDR1(2), DGKI(5), IL6ST(1), RPL10(1), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL22(10), RPL27A(1), RPL3(1), RPL31(1), RPL36(1), RPL5(1), RPL6(1), RPL9(2), RPLP0(2), RPS10(1), RPS11(1), RPS13(1), RPS14(1), RPS23(1), RPS27A(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6), RPS6KB1(2), RPS6KB2(2), RPSA(4), SLC36A2(3), TBC1D10C(1), TSPAN9(1), UBC(3)	10756375	90	42	81	33	21	24	21	6	18	0	0.54	0.86
389	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS2(4), CPOX(1), FECH(3), UROS(3)	1543066	14	13	14	6	5	5	1	2	1	0	0.54	0.86
390	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(1), AGTR1(1), AGTR2(1), COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), REN(3)	5174099	34	26	34	16	11	9	6	5	3	0	0.55	0.86
391	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(13), RANGAP1(4)	1679923	18	13	18	13	1	7	4	5	1	0	0.55	0.86
392	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(4), JAK1(5), JAK2(4), TYK2(4)	2104725	19	13	19	11	3	6	3	2	3	2	0.55	0.86
393	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(4), JAK1(5), JAK2(4), TYK2(4)	2104725	19	13	19	11	3	6	3	2	3	2	0.55	0.86
394	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM1(1), CALM2(2), CALM3(1), CXCR4(2), GNAQ(1), JUN(2), MAPK14(1), MAPK8(4), PLCG1(9), PTK2B(8)	2644838	31	20	30	8	12	13	5	0	1	0	0.55	0.86
395	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), FDXR(1), SHMT1(1)	3226314	31	21	31	11	7	9	9	3	3	0	0.55	0.86
396	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22RA1(1), IL22RA2(1), JAK1(5), JAK2(4), JAK3(3), SOCS3(2), STAT1(3), STAT3(4), STAT5B(4), TYK2(4)	3790101	32	22	32	11	7	14	3	1	5	2	0.55	0.86
397	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), EHHADH(1), HADHA(2), SDS(1)	2460367	25	19	24	6	8	9	4	0	4	0	0.55	0.86
398	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(7), DDX20(3), ETS1(3), ETS2(1), HDAC2(3), HDAC5(3), JUN(2), NCOR2(12), RBL1(3), RBL2(1), SIN3A(4), SIN3B(5)	5431587	47	27	47	22	9	25	7	2	4	0	0.55	0.86
399	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(5), EPHB1(9), FYN(3), ITGA1(4), ITGB1(2), L1CAM(3), LYN(2), RAP1B(2), SELP(2)	3156755	33	20	33	23	6	15	6	4	2	0	0.56	0.86
400	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(4), ALDOC(2), FBP2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), MDH1(1), ME1(3), ME2(4), ME3(4), PGK1(1), PKLR(4), PKM2(2), TPI1(1)	3544450	37	24	36	14	10	18	6	1	2	0	0.56	0.86
401	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA2(1), ACADM(1), ACAT1(2), ACAT2(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), AOX1(3), AUH(5), BCAT1(2), BCAT2(1), BCKDHA(3), DBT(2), DLD(2), EHHADH(1), HADH(2), HADHA(2), HADHB(2), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), IVD(1), MCCC1(1), MCCC2(2), MCEE(2), MUT(3), OXCT1(2), PCCA(7), PCCB(2)	8707510	73	32	70	24	17	20	14	4	16	2	0.57	0.86
402	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL13(1), MAF(1), MAP2K3(1), MAPK14(1), NFATC2(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5)	2436427	23	18	23	9	7	9	3	4	0	0	0.57	0.86
403	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(3), GALNT2(2), GALNT3(1), GALNT4(1), GALNT6(1), GALNT8(3), GCNT1(1), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), WBSCR17(7)	2879849	28	21	28	7	11	7	6	2	2	0	0.57	0.86
404	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(4), PLCB1(8), RELA(2)	1670613	15	11	15	6	2	4	4	1	4	0	0.57	0.86
405	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(1), HBXIP(1), PTK2B(8), SHC1(3), SOS1(3)	1784727	20	14	20	5	5	7	3	1	4	0	0.57	0.86
406	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(4), SULT1E1(1), SULT2A1(1)	1215088	14	10	14	3	3	6	4	0	1	0	0.57	0.86
407	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(2), CD3E(1), CD3G(2), CD4(3), IFNG(2), IL12B(1), IL12RB1(3), IL12RB2(3), JAK2(4), STAT4(4), TYK2(4)	2861761	29	19	28	14	1	13	7	1	7	0	0.57	0.87
408	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(2), CDC25B(4), CDC25C(2), CHEK1(2), WEE1(1)	2771587	27	18	26	3	5	7	9	0	4	2	0.58	0.87
409	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(2), FARSB(1), GOT1(2), GOT2(2), PAH(4), TAT(1), YARS2(1)	1755068	17	14	17	10	2	11	3	0	1	0	0.58	0.87
410	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PDXK(3), PDXP(1), PNPO(1)	976087	8	7	8	2	0	2	1	1	2	2	0.58	0.87
411	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), MMP9(5), RECK(4), TIMP3(2)	1517530	14	11	14	10	2	7	2	0	3	0	0.58	0.87
412	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(6), DLD(2), FH(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(3), PDHA1(1), PDHA2(4), PDHB(2), PDHX(1), PDK1(1), PDK3(2), PDP2(1), SDHA(4), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(3)	5737354	53	31	52	28	10	20	13	2	8	0	0.59	0.88
413	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), MAN2B1(7), MAN2B2(6), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1)	4184446	42	23	42	20	8	17	5	7	5	0	0.59	0.88
414	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(2), NEK1(4), WEE1(1)	1479226	14	12	14	3	3	2	3	2	4	0	0.59	0.88
415	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(1), MEF2B(2), MEF2C(1), MEF2D(3), MYOD1(3)	1660904	14	14	14	6	3	8	2	1	0	0	0.60	0.88
416	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS7(1), ESCO2(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1)	3204768	23	20	23	5	4	6	8	2	3	0	0.60	0.88
417	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(2), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST12(5), CHST13(1), CHST3(1), CHST7(1), DSE(6), UST(3), XYLT1(5), XYLT2(3)	3011785	33	21	33	9	6	13	10	2	2	0	0.60	0.89
418	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(6), EIF2AK4(4), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF5(2), GSK3B(1), PPP1CA(2)	2346918	22	18	22	7	4	8	6	3	1	0	0.60	0.89
419	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	304437	3	3	3	2	1	1	0	0	1	0	0.61	0.89
420	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(5), LCT(10), PGM1(2), PYGL(4), PYGM(6), TPI1(1), TREH(4)	2700299	32	19	32	9	11	12	3	2	4	0	0.61	0.89
421	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(3), GABARAPL1(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(4), PIK3R4(7), PRKAA1(1), PRKAA2(2), ULK1(1), ULK2(2), ULK3(1)	4273157	39	23	39	17	10	5	14	3	7	0	0.61	0.89
422	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(4), JUN(2), KEAP1(4), MAPK1(2), MAPK14(1), MAPK8(4), NFE2L2(1)	1781003	18	15	18	6	6	9	1	1	1	0	0.62	0.90
423	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(1), C1GALT1C1(3), GALNT1(2), GALNT10(3), GALNT11(3), GALNT12(1), GALNT13(3), GALNT14(5), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT8(3), GALNTL1(2), GALNTL2(4), GALNTL4(4), GALNTL5(4), GCNT1(1), GCNT3(2), GCNT4(1), OGT(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(1), WBSCR17(7)	6502769	68	33	67	25	17	26	17	5	3	0	0.62	0.90
424	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(2), ALPP(3), ALPPL2(4)	1370698	12	10	11	6	1	8	0	2	1	0	0.62	0.90
425	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(6), ATP4B(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), ATP7B(10), COX10(1), COX4I1(3), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1), PPA2(1), SDHA(4), SDHB(3), SHMT1(1), UQCRB(1), UQCRC1(2)	7025459	78	35	78	22	17	25	23	5	8	0	0.62	0.90
426	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(1), ARFGAP3(3), ARFGEF2(9), CLTA(2), COPA(1), GBF1(8), GPLD1(6)	3263554	32	22	32	10	10	9	8	4	1	0	0.62	0.90
427	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO3(2), FARS2(4), GOT1(2), GOT2(2), PAH(4), TAT(1)	1652525	17	14	17	9	3	12	1	0	1	0	0.62	0.90
428	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(1), COMT(1), DBH(2), DDC(3), GAD1(3), GAD2(3), HDC(3), MAOA(1), PAH(4), PNMT(2), TH(1)	2972550	28	21	28	10	7	14	3	2	2	0	0.63	0.90
429	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), IL8(1)	340613	2	2	2	2	0	2	0	0	0	0	0.63	0.90
430	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), ALAS2(4), CPO(1), FECH(3), GATA1(1), UROS(3)	1651195	15	13	15	7	5	5	1	3	1	0	0.63	0.91
431	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(2), GRB2(1), IL6(1), IL6ST(1), JAK1(5), JAK2(4), JAK3(3), JUN(2), MAP2K1(3), MAPK3(1), PTPN11(3), RAF1(6), SHC1(3), SOS1(3), SRF(1), STAT3(4)	4898390	47	27	47	16	14	16	7	5	3	2	0.64	0.91
432	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), AGTR2(1), EDN1(2), EDNRA(2), EDNRB(10), EGF(4), EGFR(7), JUN(2), NFKB1(4), PLCG1(9), RELA(2)	4155053	46	24	44	17	14	17	6	1	8	0	0.64	0.92
433	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(4), GREB1(8), HSPB1(1), HSPB2(1), MTA1(4), PDZK1(2), TUBA8(3)	2279088	24	16	24	8	4	10	4	1	5	0	0.65	0.92
434	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(2), CYP11B2(2), CYP17A1(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1390382	13	11	13	4	5	4	1	3	0	0	0.65	0.92
435	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH5A1(3), ALDH9A1(3), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), HMGCL(1), OXCT1(2), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(1)	5205487	54	29	53	21	15	23	8	2	6	0	0.65	0.92
436	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(3), ALG10B(1), ALG13(1), ALG3(2), ALG9(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), DOLPP1(1), DPM1(1), FUT8(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(6), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(4)	8660960	58	35	57	26	15	16	14	2	11	0	0.65	0.92
437	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(3), ASAH1(1), CERK(3), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(3), GALC(4), GBA(2), GLB1(2), LCT(10), NEU1(1), NEU2(2), NEU3(1), PPAP2C(4), SGMS1(2), SMPD1(3), SMPD3(4), SMPD4(3), SPHK1(4), SPTLC2(2), UGT8(2)	7343063	65	36	65	31	20	26	9	7	3	0	0.65	0.92
438	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(2), SQLE(3)	877667	8	6	7	2	1	2	1	1	3	0	0.65	0.92
439	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(2), CUL1(5), NEDD8(1), RB1(6), SKP2(2)	1754669	16	12	15	1	1	4	6	2	3	0	0.66	0.92
440	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), DLD(2), FH(1), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), PC(3), PCK1(3), SDHA(4), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(3)	4140822	39	24	38	15	5	20	7	2	5	0	0.66	0.92
441	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), CAPN2(3), CAPNS1(1), EGF(4), EGFR(7), ITGA1(4), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTK2(5), PXN(2), TLN1(9)	6610366	62	33	62	30	20	23	6	5	8	0	0.66	0.92
442	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNA2(1), CCNE2(1), CDK2(2), CDKN2A(2), PRB1(1)	1757462	9	9	9	9	2	0	5	1	1	0	0.66	0.92
443	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(3), CTH(2), GOT1(2), GOT2(2), LDHB(2), LDHC(1), MPST(1)	1374954	13	11	13	3	2	7	3	0	1	0	0.67	0.93
444	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), HDAC5(3), MEF2B(2), MEF2C(1), MEF2D(3), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(1)	4141620	31	23	31	10	8	13	6	1	3	0	0.68	0.93
445	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(1), AP2M1(5), CALM1(1), CALM2(2), CALM3(1), DNM1(4), EPN1(3), PICALM(1), PPP3CA(2), PPP3CB(1), SYNJ1(5), SYNJ2(13)	4521335	45	25	42	10	11	18	7	3	6	0	0.68	0.93
446	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAK1(1), BID(1), BIRC2(1), BIRC3(3), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1)	2756957	22	18	22	4	4	7	5	2	4	0	0.68	0.93
447	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(3), CFL1(1)	775922	5	5	5	2	0	3	0	0	2	0	0.68	0.93
448	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), AANAT(1), ABP1(6), ACAT1(2), ACAT2(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), AOX1(3), CARM1(1), CAT(4), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(3), EHHADH(1), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), INMT(1), KYNU(4), LCMT1(1), LCMT2(4), LNX1(1), MAOA(1), MAOB(2), METTL6(1), NFX1(2), OGDH(7), OGDHL(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(1), TPH2(3), WARS(3), WARS2(4), WBSCR22(1)	12112177	105	44	101	29	23	31	20	9	18	4	0.68	0.93
449	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), BIRC2(1), BIRC3(3), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(2), LMNB1(1), LMNB2(3), PRF1(1)	3910333	33	23	33	10	8	9	7	5	4	0	0.68	0.93
450	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL16(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(1), TNF(1)	1975316	16	13	16	9	0	7	9	0	0	0	0.68	0.93
451	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(4), EGFR(7), RAB5A(2), TF(5), TFRC(1)	2599618	21	16	21	11	4	8	4	1	4	0	0.69	0.93
452	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(7), AMY2A(1), AMY2B(2), ASCC3(14), ATP13A2(6), DDX18(7), DDX19A(2), DDX23(2), DDX4(1), DDX41(5), DDX47(2), DDX50(2), DDX54(5), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(3), ENTPD7(6), EP400(2), ERCC2(3), ERCC3(3), GAA(2), GANC(3), GBA(2), GBA3(1), GBE1(3), GCK(2), GPI(4), GUSB(1), GYS1(4), GYS2(2), HK1(5), HK2(3), HK3(2), IFIH1(3), LYZL1(2), MGAM(4), NUDT5(1), NUDT8(1), PGM1(2), PGM3(5), PYGB(4), PYGL(4), PYGM(6), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SI(9), SKIV2L2(3), SMARCA2(13), SMARCA5(1), TREH(4), UGDH(1), UGP2(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), UXS1(1)	24781092	217	60	215	74	50	69	45	21	32	0	0.69	0.93
453	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(2), ENPP6(1), PAFAH1B1(3), PAFAH1B2(2), PAFAH1B3(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLD1(6), PLD2(10), PPAP2C(4)	4707136	55	28	55	14	9	27	11	3	5	0	0.69	0.93
454	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(6), ACSS2(2), ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GALM(1), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(6), PFKM(1), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1)	11509554	132	44	131	45	37	52	22	10	11	0	0.69	0.93
455	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(11), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADIPOQ(2), ADIPOR1(1), ADIPOR2(2), AKT1(2), AKT2(1), AKT3(3), CAMKK1(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(3), IKBKB(3), IRS1(5), IRS2(3), IRS4(9), JAK1(5), JAK2(4), JAK3(3), LEPR(7), MAPK10(3), MAPK8(4), MAPK9(1), NFKB1(4), NFKB2(2), NFKBIB(3), NPY(1), PCK1(3), PCK2(4), POMC(5), PPARA(2), PPARGC1A(5), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKCQ(1), PTPN11(3), RELA(2), RXRA(2), RXRG(2), SLC2A1(3), SLC2A4(1), SOCS3(2), STAT3(4), TNF(1), TNFRSF1A(3), TRAF2(2), TYK2(4)	16985164	160	51	160	67	36	70	20	8	24	2	0.69	0.93
456	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(2), GFPT1(3), GNE(1), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(2), HK1(5), HK2(3), HK3(2), PGM3(5)	3425415	31	23	31	11	13	10	6	1	1	0	0.69	0.93
457	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(3), CDC42(1), CFL1(1), FLNA(5), FLNC(18), FSCN1(4), FSCN3(6), GDI1(1), LIMK1(2), MYH2(9), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PFN2(2), RHO(1), ROCK1(5), ROCK2(2), VASP(2), WASF1(3), WASL(1)	9799174	98	38	98	39	33	28	21	9	7	0	0.69	0.93
458	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(2), TOP2A(3), TOP2B(8)	2033836	21	13	19	4	1	6	6	1	7	0	0.69	0.93
459	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(3), HDC(3), PNMT(2), TH(1)	1237698	11	9	11	5	2	5	3	1	0	0	0.70	0.93
460	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(1), CREB1(4), CREB3(3), CREB5(2), DUSP1(1), DUSP10(2), EEF2K(6), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(2), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K10(5), MAP3K4(5), MAP3K7(7), MAPK1(2), MAPK13(1), MAPK14(1), MAPKAPK5(1), MKNK1(1), MYEF2(3), NFKB1(4), NR2C2(3), SRF(1), TRAF6(3)	6868652	72	33	71	22	11	34	13	3	11	0	0.70	0.94
461	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1)	3403603	29	18	29	17	6	9	4	5	5	0	0.70	0.94
462	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(2)	378385	4	3	4	2	0	2	2	0	0	0	0.71	0.94
463	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(4), LPA(6), MAP2K4(5), MAP3K1(5), MAPK8(4), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PDK1(1), PHKA2(4), PI3(2), PIK3CB(4), PLD1(6), PLD2(10), PLD3(5), PTK2(5), RDX(1), ROCK1(5), ROCK2(2), SERPINA4(1), SRF(1), TBXA2R(6)	9997078	107	41	107	36	21	48	21	6	11	0	0.71	0.94
464	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(1), MST1(2), MST1R(7), TNF(1)	1331729	11	10	11	1	4	4	1	1	1	0	0.72	0.95
465	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), ALOX5(2), CYP1A2(3), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), HSD3B7(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1)	4813935	48	27	48	12	10	19	10	5	4	0	0.72	0.96
466	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASS(1), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BBOX1(1), DOT1L(8), EHHADH(1), EHMT2(2), GCDH(3), HADHA(2), PLOD1(5), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(3)	7546420	66	33	65	21	15	20	17	3	11	0	0.72	0.96
467	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(2), IFNAR2(3), IFNB1(2), MAPK8(4), NFKB1(4), RELA(2), TNFRSF11A(4), TNFSF11(1), TRAF6(3)	2251690	26	17	26	8	6	8	6	2	4	0	0.72	0.96
468	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(3), HMGCR(4), MVD(1), MVK(3), NQO1(3), NQO2(2), SC5DL(1), SQLE(3), VKORC1(1)	2295713	23	16	23	8	5	10	3	3	2	0	0.73	0.96
469	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BID(1), BIRC2(1), BIRC3(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(2), MAP3K14(1), NFKB1(4), RELA(2), SPTAN1(8), TNFRSF10A(2), TNFRSF10B(1), TNFRSF25(2), TNFSF10(2), TRAF2(2)	6839924	47	31	47	17	10	16	6	6	9	0	0.73	0.96
470	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(11), EP300(10), HDAC3(3), IKBKB(3), NFKB1(4), RELA(2), TNF(1), TNFRSF1A(3), TRAF6(3)	4571210	40	23	40	13	11	11	6	2	10	0	0.73	0.96
471	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(1), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), PHPT1(3), RFK(1), TYR(1)	3012317	31	18	31	4	9	8	8	4	2	0	0.74	0.96
472	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ6(2), NDUFA13(1)	833245	6	6	6	3	2	3	1	0	0	0	0.74	0.97
473	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), AOX1(3), BCAT1(2), BCKDHA(3), EHHADH(1), HADHA(2), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(2), MCEE(2), MUT(3), OXCT1(2), PCCA(7), PCCB(2), SDS(1)	7238126	66	29	63	24	14	22	11	4	13	2	0.75	0.97
474	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(14), ACACB(11), AKT1(2), AKT2(1), AKT3(3), ARAF(6), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(1), CBLB(2), CBLC(2), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(4), FASN(3), FBP2(3), FLOT1(1), FLOT2(3), FOXO1(1), GCK(2), GRB2(1), GSK3B(1), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(7), IRS1(5), IRS2(3), IRS4(9), KRAS(7), LIPE(1), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), MKNK1(1), PCK1(3), PCK2(4), PDE3A(3), PDE3B(9), PDPK1(1), PFKL(6), PFKM(1), PFKP(7), PHKA1(4), PHKA2(4), PHKB(3), PHKG1(2), PHKG2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PKLR(4), PKM2(2), PPARGC1A(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R3A(9), PPP1R3B(1), PPP1R3C(3), PPP1R3D(2), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCI(4), PRKX(1), PTPRF(6), PYGB(4), PYGL(4), PYGM(6), RAF1(6), RAPGEF1(6), RHEB(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SLC2A4(1), SOCS2(2), SOCS3(2), SOCS4(1), SORBS1(5), SOS1(3), SOS2(4), SREBF1(3), TRIP10(6), TSC1(1), TSC2(3)	32922820	377	75	363	133	89	140	79	24	45	0	0.75	0.97
475	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(1), PFKP(7), PGK1(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1)	9693705	119	41	118	42	29	48	21	10	11	0	0.75	0.97
476	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(1), PFKP(7), PGK1(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1)	9693705	119	41	118	42	29	48	21	10	11	0	0.75	0.97
477	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(1), CD3G(2), ETV5(4), IFNG(2), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(4), JUN(2), MAP2K6(2), MAPK14(1), MAPK8(4), STAT4(4), TYK2(4)	3651249	39	21	38	12	5	15	8	2	9	0	0.75	0.97
478	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), DUSP6(1), DUSP9(2), EEF2K(6), EIF4E(1), GRB2(1), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(4), RAP1A(1), RPS6KA1(2), RPS6KA2(6), SHC1(3), SOS1(3), SOS2(4), TRAF3(2)	6059081	62	30	61	18	14	24	12	4	8	0	0.75	0.97
479	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(4), ALDOC(2), FBP2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), MDH1(1), ME1(3), ME3(4), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(3), TPI1(1)	3966193	41	24	40	15	12	20	4	4	1	0	0.76	0.97
480	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), SQLE(3)	662872	6	4	6	2	1	2	1	1	1	0	0.77	0.98
481	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(2), ACAT1(2), ACAT2(1), ACSM1(1), AKR1B10(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH5A1(3), ALDH9A1(3), DDHD1(5), EHHADH(1), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), HSD3B7(1), ILVBL(2), OXCT1(2), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1)	8272733	64	36	62	25	20	24	10	4	6	0	0.77	0.98
482	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(4), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2D6(2), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4F8(1), CYP51A1(2)	5930470	62	31	61	16	19	23	9	6	5	0	0.77	0.99
483	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	COPS5(2), CREB1(4), EDN1(2), EP300(10), HIF1A(1), JUN(2), NOS3(2), P4HB(1)	3423952	24	20	24	7	6	6	5	1	6	0	0.77	0.99
484	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(5), JAK2(4), STAT1(3)	1646673	17	10	17	6	4	6	2	1	2	2	0.78	0.99
485	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(14), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), EHHADH(1), HADHA(2), LDHB(2), LDHC(1), MCEE(2), MLYCD(2), MUT(3), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(2), SUCLG2(3)	6633641	76	30	73	20	19	23	13	5	16	0	0.78	0.99
486	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2A(1), UBE2B(1), UBE2D3(1), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J2(3), UBE2L6(1), UBE2N(1), UBE3A(3)	2127734	21	15	21	13	6	8	2	2	3	0	0.78	0.99
487	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(1), IL2RG(2), IRS1(5), JAK1(5), JAK3(3), RPS6KB1(2), SHC1(3)	3042508	23	17	22	15	7	4	5	1	4	2	0.79	0.99
488	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(1), FURIN(2), NOTCH1(9), PSEN1(1)	1987020	14	12	14	17	2	9	1	1	1	0	0.79	0.99
489	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), CHST12(5), CHST13(1), PAPSS1(4), PAPSS2(2), SULT1A1(2), SULT1A2(4), SULT1E1(1), SULT2A1(1)	1901102	23	13	23	7	6	9	6	0	2	0	0.79	0.99
490	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(6), ADCY3(2), ADCY9(4), ARF1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), GNAS(12), PLCG1(9), PLCG2(5), SEC61B(1), SEC61G(1), TRIM23(2)	7479787	64	32	62	25	16	27	10	6	5	0	0.79	0.99
491	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(1), FYN(3), JUN(2), MAPK14(1), THBS1(5)	1482684	13	12	13	3	6	3	2	1	1	0	0.79	0.99
492	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), HMGCL(1), OXCT1(2)	673911	6	5	6	4	2	2	0	1	1	0	0.79	0.99
493	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), MARCKS(2), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), SP1(2), SP3(2)	4252542	41	23	39	11	15	11	10	0	5	0	0.79	0.99
494	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT9(1), GCNT2(2), ST8SIA1(3)	1270416	8	7	8	1	2	3	1	2	0	0	0.80	0.99
495	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKA(1), CHPT1(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), ESCO2(1), ETNK2(2), GNPAT(1), GPAM(4), GPD1(2), GPD1L(3), GPD2(2), LCAT(1), LYPLA2(1), MYST3(6), MYST4(12), NAT6(1), PCYT1A(6), PEMT(1), PISD(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLD1(6), PLD2(10), PNPLA3(1), PPAP2C(4), PTDSS1(1), SH3GLB1(1)	13520514	122	45	122	35	29	48	26	8	11	0	0.80	0.99
496	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(13), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), BTRC(2), CDC20(2), CDC23(4), CDC26(1), CDC27(1), CUL1(5), CUL2(4), CUL3(2), FBXW11(4), FBXW7(8), FZR1(3), ITCH(2), SKP2(2), SMURF1(1), UBE2D3(1), UBE2E3(3), WWP1(6), WWP2(9)	8206366	81	36	71	20	18	24	21	5	13	0	0.80	0.99
497	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), P4HB(1), SLC23A1(5), SLC23A2(5), SLC2A1(3), SLC2A3(1)	5127682	38	24	38	19	11	11	4	5	7	0	0.80	0.99
498	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP4K2(3), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TANK(1), TNF(1), TNFRSF1A(3), TRAF2(2)	5004923	43	25	43	15	10	17	5	5	6	0	0.80	0.99
499	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLS(4), GLUD1(3)	1080359	10	7	10	4	3	3	3	0	1	0	0.80	0.99
500	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), GRB2(1), IL3(1), JAK2(4), MAP2K1(3), MAPK3(1), RAF1(6), SHC1(3), SOS1(3), STAT5B(4)	3419031	31	19	31	10	6	13	6	2	4	0	0.80	0.99
501	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(2), CDC25A(2), CDC25B(4), CDC25C(2), MNAT1(2), XPO1(2)	1775550	15	10	15	3	1	6	4	0	4	0	0.80	0.99
502	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CALM1(1), CALM2(2), CALM3(1), CD79A(5), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP3K1(5), MAPK14(1), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(6), SHC1(3), SOS1(3), SYK(1), VAV1(2)	7736876	76	34	74	25	26	24	17	2	7	0	0.81	0.99
503	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), LCT(10), SPAM1(2)	4206657	38	24	37	15	5	19	9	4	1	0	0.81	0.99
504	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(5), HK2(3), HK3(2), IMPA1(2), PGM1(2), PGM3(5), TGDS(2)	2059505	23	16	23	10	9	9	3	0	2	0	0.81	0.99
505	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(6), PGAP1(3), PIGA(2), PIGB(3), PIGC(1), PIGG(5), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(3), PIGV(2), PIGX(2), PIGZ(2)	4953718	42	26	42	10	12	14	9	3	4	0	0.81	0.99
506	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(1), RDH11(1), RDH12(1)	978614	8	7	8	3	4	3	0	1	0	0	0.81	0.99
507	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), GFPT1(3), GFPT2(1), GNE(1), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(2), HK1(5), HK2(3), HK3(2), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), NPL(1), PGM3(5), PHPT1(3)	5795475	50	30	50	16	19	13	14	3	1	0	0.81	0.99
508	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), IDS(3), LCT(10)	2959649	23	17	23	12	5	7	7	3	1	0	0.81	0.99
509	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(1), RFK(1), TYR(1)	1937544	16	11	16	3	3	5	4	2	2	0	0.82	0.99
510	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(5), PER1(3)	1746556	15	11	15	4	4	5	0	4	2	0	0.82	0.99
511	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP4(1), ARHGAP5(6), ARHGAP6(3), ARHGEF1(1), ARHGEF11(8), ARHGEF5(5), ARPC1A(1), ARPC1B(1), ARPC4(1), CFL1(1), DIAPH1(3), GSN(4), LIMK1(2), MYL2(1), MYLK(7), OPHN1(6), PIP5K1A(2), PPP1R12B(2), ROCK1(5), TLN1(9), VCL(2)	9397514	73	34	73	33	19	28	10	5	9	2	0.82	0.99
512	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(1), ME1(3), PC(3), PDHA1(1), SLC25A1(2)	1874635	12	10	12	7	0	7	3	1	1	0	0.83	0.99
513	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1)	4701683	39	25	39	13	6	19	6	5	3	0	0.83	1.00
514	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(3), IFNB1(2), JAK1(5), STAT1(3), STAT2(1), TYK2(4)	2170959	21	12	21	8	3	7	5	1	3	2	0.83	1.00
515	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), GRHPR(2), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	2562112	17	14	16	12	2	8	2	3	2	0	0.83	1.00
516	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(1), BIRC3(3), CASP3(1), CASP8(3), JUN(2), MAP2K4(5), MAP3K3(1), MAP3K7(7), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), NR2C2(3), RALBP1(7), TNF(1), TNFAIP3(4), TNFRSF1A(3), TRAF2(2)	5596507	59	27	59	10	13	22	11	3	10	0	0.84	1.00
517	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(2), UGDH(1), UXS1(1)	801857	6	5	6	3	2	1	2	0	1	0	0.84	1.00
518	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(14), ACACB(11), FASN(3), OXSM(2)	3309572	30	17	30	9	7	8	3	3	9	0	0.84	1.00
519	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(1), FUCA1(1), FUCA2(2), GBA(2), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), LCT(10), MAN2B1(7), MAN2B2(6), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1), SPAM1(2)	7115899	67	32	66	27	9	32	11	10	5	0	0.84	1.00
520	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(1)	325052	2	2	2	0	2	0	0	0	0	0	0.85	1.00
521	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS7(1), LCMT1(1), LCMT2(4), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(1)	2906582	18	15	18	7	5	4	4	1	4	0	0.85	1.00
522	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PLCG1(9), RAF1(6), SHC1(3), SOS1(3), STAT5B(4)	4379424	48	24	47	10	14	20	6	3	5	0	0.85	1.00
523	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ACYP2(1), EHHADH(1), GCDH(3), HADHA(2), SDHB(3), SDS(1)	1579508	14	10	13	2	2	4	3	2	3	0	0.85	1.00
524	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(2), FDPS(3), HMGCR(4), HMGCS1(1), MVD(1), MVK(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(3)	2714530	25	16	25	8	8	7	5	3	2	0	0.85	1.00
525	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(14), CPT1A(2), LEPR(7), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2)	2904321	31	17	31	9	6	10	5	3	7	0	0.85	1.00
526	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(3)	2969890	21	16	21	8	10	5	2	1	3	0	0.85	1.00
527	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(2), GRB2(1), IL2(1), IL2RA(1), IL2RG(2), JAK1(5), JAK3(3), JUN(2), LCK(1), MAP2K1(3), MAPK3(1), MAPK8(4), RAF1(6), SHC1(3), SOS1(3), STAT5B(4), SYK(1)	4803428	47	24	46	11	13	14	8	4	6	2	0.85	1.00
528	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(5), HK2(3), HK3(2), IMPA1(2), ISYNA1(2), PGM1(2), PGM3(5), TGDS(2)	2372720	25	17	25	13	10	9	3	1	2	0	0.86	1.00
529	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1812923	16	12	16	6	5	7	2	2	0	0	0.86	1.00
530	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1812923	16	12	16	6	5	7	2	2	0	0	0.86	1.00
531	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADK(2), NADSYN1(3), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(6), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT12(1)	4365060	32	21	32	18	10	7	6	4	3	2	0.86	1.00
532	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2G(3), DAG1(7), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), NFAT5(5), PDE6A(1), PDE6B(7), PDE6C(2), TF(5)	7333620	73	30	73	30	13	26	17	3	12	2	0.86	1.00
533	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CYP2C19(4), CYP2C9(1), DHRS7(1), EHHADH(1), ESCO2(1), HADHA(2), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1), YOD1(2)	6125714	49	28	48	10	12	14	13	4	6	0	0.87	1.00
534	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(4), ALDOC(2), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GOT1(2), GOT2(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), PC(3), PCK1(3), PDHA1(1), PDHA2(4), PDHB(2), PDHX(1), PFKL(6), PFKM(1), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(3), TPI1(1)	8432998	89	36	89	39	26	44	11	4	4	0	0.87	1.00
535	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(2), CDK2(2), DIAPH2(3), MCM10(2), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), NACA(1), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), POLA2(1), POLD1(4), POLD3(2), POLE2(1), PRIM1(1), RFC1(1), RFC2(1), RFC3(4), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3)	10370010	77	36	76	30	10	26	17	6	18	0	0.87	1.00
536	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), GRHPR(2), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	2684206	17	14	16	12	2	8	2	3	2	0	0.87	1.00
537	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(3), ARG1(1), ASL(4), CKMT1A(1), CKMT2(2), CPS1(8), GATM(1), GLUD1(3), NAGS(1), ODC1(3), OTC(1), SMS(2)	3506678	30	19	30	8	7	10	11	1	1	0	0.88	1.00
538	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), DAZAP2(2), DNAJA1(1), EIF4G2(1), ETV6(3), G0S2(1), GFRA1(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), KLF9(1), MYF6(1), NCKAP1(4), NR1D2(3), PER1(3), PER2(6), PPP1R3C(3), PSMA4(3), PURA(1), SF3A3(2), TOB1(1), UCP3(2), UGP2(1), ZFR(5)	7434035	61	33	61	20	12	21	16	8	4	0	0.88	1.00
539	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), TGM2(4)	1022371	6	6	6	4	3	3	0	0	0	0	0.89	1.00
540	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(2), ACAT2(1), ACOT11(2), ACYP2(1), DHRS7(1), EHHADH(1), ESCO2(1), GCDH(3), HADHA(2), ITGB1BP3(3), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1), YOD1(2)	5115712	40	25	39	8	6	10	12	5	7	0	0.89	1.00
541	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(14), ATP13A2(6), DDX18(7), DDX19A(2), DDX23(2), DDX4(1), DDX41(5), DDX47(2), DDX50(2), DDX54(5), DDX55(3), DDX56(4), DHX58(4), ENTPD7(6), EP400(2), ERCC2(3), ERCC3(3), IFIH1(3), NUDT5(1), NUDT8(1), QDPR(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(13), SMARCA5(1)	12847002	124	42	121	40	25	49	20	12	18	0	0.89	1.00
542	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(1)	1010268	7	6	7	4	2	2	2	0	1	0	0.89	1.00
543	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(5), NPAS2(4), NR1D1(1), PER1(3), PER2(6), PER3(5)	3475290	31	18	31	11	5	11	5	5	5	0	0.89	1.00
544	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), CREBBP(11), CTBP1(2), CTBP2(2), DLL1(1), DLL3(1), DLL4(1), DTX1(7), DTX2(1), DTX3L(1), DTX4(3), DVL1(3), DVL2(2), DVL3(3), EP300(10), HDAC1(2), HDAC2(3), JAG1(3), JAG2(1), MAML1(4), MAML2(6), MAML3(7), NCOR2(12), NCSTN(2), NOTCH1(9), NOTCH2(9), NOTCH3(8), NOTCH4(6), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(1), PSENEN(1), PTCRA(1), RBPJ(1), RBPJL(1)	14493010	132	42	128	63	33	45	20	12	22	0	0.89	1.00
545	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(1), ARSE(3), ASAH1(1), GAL3ST1(3), GALC(4), GBA(2), GLB1(2), LCT(10), NEU1(1), NEU2(2), NEU3(1), PPAP2C(4), SMPD1(3), SPTLC2(2)	4961698	41	25	41	25	9	18	6	6	2	0	0.89	1.00
546	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K7(7), MAP3K9(3), MAPK14(1), MAPKAPK5(1), MEF2B(2), MEF2C(1), MEF2D(3), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TRAF2(2)	7469280	68	30	68	25	16	26	13	4	9	0	0.89	1.00
547	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(5), CPOX(1), EARS2(2), EPRS(3), FECH(3), FTH1(1), FTMT(1), GUSB(1), HCCS(1), HMOX1(3), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), UROS(3)	8082011	54	31	54	27	15	19	10	6	4	0	0.90	1.00
548	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(3), PTGS1(4), PTGS2(1)	1058813	11	7	11	6	4	5	1	1	0	0	0.90	1.00
549	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(6), IARS2(3), ILVBL(2), LARS(2), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2), VARS(5), VARS2(3)	3763900	32	20	32	10	6	14	8	0	4	0	0.90	1.00
550	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADSYN1(3), NMNAT1(1), NNMT(1), NNT(6)	2942758	20	15	20	13	5	4	4	3	2	2	0.90	1.00
551	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1), ACAT1(2), HADHA(2)	1097383	6	6	5	1	0	0	1	2	3	0	0.90	1.00
552	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(2), RAB27A(2), RAB5A(2), RAB6A(1)	865298	8	5	8	10	2	2	4	0	0	0	0.91	1.00
553	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CPT1A(2), CPT1C(2), CPT2(3), CYP4A22(1), EHHADH(1), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(2)	9838010	83	33	81	17	15	26	15	10	17	0	0.91	1.00
554	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(1), CASP8AP2(4), CASP9(1), CES1(5)	2318190	17	13	17	9	4	10	1	1	1	0	0.91	1.00
555	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(6), SP1(2), SP3(2)	1340906	10	8	9	4	2	0	7	0	1	0	0.91	1.00
556	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(1), CAPNS1(1), CDK5(2), GSK3B(1), MAPT(4), PPP2CA(1)	1928101	12	11	12	11	5	4	2	0	1	0	0.92	1.00
557	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(1), HSPB1(1), HSPB2(1), MAPKAPK3(3), TNF(1)	2292521	16	13	16	12	7	6	2	0	1	0	0.92	1.00
558	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(2), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), IL2(1), IL2RA(1)	2553467	21	14	21	10	4	5	7	2	3	0	0.93	1.00
559	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(2), MECR(2), PPT2(2)	1723414	13	8	12	3	1	3	4	1	4	0	0.93	1.00
560	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(2), IKBKB(3), IL2(1), JUN(2), MAP3K1(5), MAP4K5(4), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TNFRSF9(3), TRAF2(2)	3993591	33	20	32	9	8	13	6	1	5	0	0.93	1.00
561	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), CASP8(3), CASP9(1), CYCS(1), JUN(2), PRF1(1)	2581397	21	14	21	6	7	6	1	1	4	2	0.93	1.00
562	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(4), APOC1(1), APOC2(2), CETP(2), CYP7A1(3), HMGCR(4), LCAT(1), LDLR(3), LIPC(1), LPL(1), LRP1(14), SCARB1(3), SOAT1(4)	5054266	43	23	43	16	12	16	7	4	4	0	0.93	1.00
563	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC3A(1), APOBEC3B(2), APOBEC3G(1)	1466724	9	8	9	6	4	3	1	1	0	0	0.94	1.00
564	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(2), ST3GAL4(1)	1461005	8	7	8	4	1	6	0	1	0	0	0.94	1.00
565	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(1), CDC40(5), CLK2(2), CLK3(4), CLK4(2), COL2A1(7), CPSF1(8), CPSF2(1), CPSF3(1), CPSF4(2), CSTF1(3), CSTF2(2), CSTF2T(1), CSTF3(2), DDIT3(3), DDX1(3), DDX20(3), DHX15(5), DHX16(4), DHX38(5), DHX8(4), DHX9(1), DICER1(3), DNAJC8(1), METTL3(1), NCBP1(3), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(3), PRPF3(2), PRPF4(4), PRPF4B(8), PRPF8(7), PSKH1(3), PTBP1(2), PTBP2(1), RBM5(3), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(3), SF4(3), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(2), SFRS5(4), SFRS6(5), SFRS7(1), SFRS8(5), SFRS9(1), SNRPA(4), SNRPB(1), SNRPD1(2), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SPOP(2), SRPK1(2), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(2), U2AF2(3), XRN2(11)	21322693	219	54	219	65	54	83	36	24	22	0	0.94	1.00
566	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(14), ACACB(11), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(6), ACSS2(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), EHHADH(1), HADHA(2), LDHAL6B(1), LDHB(2), LDHC(1), MCEE(2), MLYCD(2), MUT(3), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(2), SUCLG2(3)	7957523	85	31	82	25	23	25	14	4	19	0	0.94	1.00
567	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP54(2), SRP72(3), SRPR(2)	1504496	9	8	9	4	2	5	1	0	1	0	0.94	1.00
568	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8)	2797123	22	14	22	10	2	12	4	2	2	0	0.94	1.00
569	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(2), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(4), RELA(2), SOD2(1)	2579402	18	12	18	8	3	7	1	2	5	0	0.94	1.00
570	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(3), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F2(2), GTF2H1(1), MNAT1(2), POLR1A(7), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(5), POLR3D(1), POLR3E(1), TAF5(2), TAF6(6), TAF7(4), TBP(2)	7127071	60	29	60	22	17	24	8	3	8	0	0.95	1.00
571	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2)	1474837	8	7	8	5	3	2	1	1	1	0	0.95	1.00
572	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(5), MAP3K14(1), NFKB1(4), RELA(2), TNFAIP3(4), TRAF3(2), TRAF6(3)	3684632	27	18	27	9	5	13	4	1	4	0	0.95	1.00
573	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(1), ABP1(6), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), AOX1(3), CAT(4), CYP19A1(4), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2D6(2), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4F8(1), CYP51A1(2), DDC(3), EHHADH(1), GCDH(3), HADHA(2), KYNU(4), MAOA(1), MAOB(2), SDS(1), TDO2(1), WARS(3), WARS2(4)	10981278	110	39	108	26	31	34	18	9	14	4	0.95	1.00
574	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(4), POLG(1), POLL(1), POLQ(11)	3407460	17	16	17	11	5	6	2	0	4	0	0.95	1.00
575	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(3)	1804544	13	10	13	2	5	4	3	0	1	0	0.96	1.00
576	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(2), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(2)	2231075	13	10	13	7	0	7	5	0	1	0	0.96	1.00
577	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(3), CTH(2), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(1), MPST(1), SDS(1), SULT1B1(1), SULT4A1(1)	2535778	17	14	17	5	5	7	3	0	2	0	0.96	1.00
578	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(5), ARF1(2), BAD(1), BTK(1), EEA1(2), GRASP(1), GSK3B(1), LYN(2), PDPK1(1), PFKL(6), PFKM(1), PFKP(7), PLCG1(9), PRKCE(3), RAB5A(2), RPS6KB1(2), VAV2(5)	5202162	54	23	53	25	12	23	10	6	3	0	0.96	1.00
579	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASS(1), KARS(2)	1391712	8	7	8	9	1	2	5	0	0	0	0.96	1.00
580	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(1), UGDH(1), UGP2(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), XYLB(4)	5035912	27	22	27	13	7	7	7	4	2	0	0.96	1.00
581	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(2), ARSD(1), ARSE(3), CARM1(1), CYP11B1(2), CYP11B2(2), CYP19A1(4), HSD11B1(1), HSD11B2(2), HSD17B1(1), HSD17B12(2), HSD17B2(1), HSD17B3(2), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(4), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), WBSCR22(1)	9714719	70	33	70	29	16	24	15	5	10	0	0.97	1.00
582	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(5), NFATC2(5), NFKB1(4), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RELA(2)	5578951	49	27	48	20	17	17	9	3	3	0	0.97	1.00
583	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), SPCS3(1)	631484	2	2	2	0	0	2	0	0	0	0	0.97	1.00
584	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOB(4), ALDOC(2), FBP2(3), FPGT(2), GCK(2), GMDS(1), GMPPA(3), HK1(5), HK2(3), HK3(2), PFKFB3(2), PFKFB4(1), PFKM(1), PFKP(7), PMM1(1), TPI1(1)	4861549	43	24	43	15	9	24	5	2	3	0	0.97	1.00
585	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(4), CARS(3), DARS(1), EARS2(2), EPRS(3), FARS2(4), FARSA(2), FARSB(1), GARS(1), HARS(4), HARS2(2), IARS(6), IARS2(3), KARS(2), LARS(2), LARS2(1), MARS(2), MARS2(1), NARS(1), NARS2(1), QARS(4), RARS(2), RARS2(1), SARS(2), SARS2(1), TARS(3), TARS2(5), VARS(5), VARS2(3), WARS(3), WARS2(4), YARS2(1)	10920630	82	38	81	33	15	43	15	5	4	0	0.97	1.00
586	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(3), DARS(1), EPRS(3), FARS2(4), GARS(1), HARS(4), IARS(6), KARS(2), LARS(2), LARS2(1), MARS(2), MARS2(1), NARS(1), QARS(4), RARS(2), SARS(2), TARS(3), WARS(3), WARS2(4)	6400226	51	27	50	17	6	30	8	5	2	0	0.97	1.00
587	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL5(1), FADS1(2), FADS2(4), FASN(3), HADHA(2), HSD17B12(2), SCD(4)	3016307	24	14	23	4	8	7	3	0	6	0	0.97	1.00
588	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKA(1), CLC(2), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), GNPAT(1), GPD1(2), GPD2(2), LCAT(1), LYPLA2(1), PAFAH1B1(3), PCYT1A(6), PEMT(1), PISD(2), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB2(3), PLCG1(9), PLCG2(5), PPAP2C(4)	10341415	85	35	84	27	21	39	14	4	7	0	0.97	1.00
589	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), CDC42(1), WASF1(3), WASL(1)	1629516	11	8	11	13	3	4	2	1	1	0	0.97	1.00
590	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(1), DHRS7(1), HSD3B7(1), PON2(2), RDH11(1), RDH12(1)	1694686	7	7	7	7	2	2	1	1	1	0	0.98	1.00
591	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(1), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(1), GALK2(1), GALT(1), GANC(3), GCK(2), GLB1(2), HK1(5), HK2(3), HK3(2), HSD3B7(1), LALBA(1), LCT(10), MGAM(4), PFKL(6), PFKM(1), PFKP(7), PGM1(2), PGM3(5), RDH11(1), RDH12(1), UGP2(1)	7908180	74	31	73	36	23	30	7	9	5	0	0.98	1.00
592	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(2), CP(5), CPOX(1), EPRS(3), FECH(3), GUSB(1), HCCS(1), HMOX1(3), UGT1A5(1), UGT2B15(1), UGT2B4(2), UROS(3)	5247515	29	20	29	17	9	13	1	3	3	0	0.98	1.00
593	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL27A(1), RPL3(1), RPL31(1), RPL36A(1), RPL6(1), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS23(1), RPS3A(1), RPS5(1), RPS6(1), RPSA(4)	4679605	30	21	30	16	8	10	6	2	4	0	0.98	1.00
594	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(2), PSMC3(5), PSMD1(3), PSMD12(1), PSMD2(9)	3196123	30	14	30	8	7	7	9	4	3	0	0.98	1.00
595	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLG(1), POLG2(3), POLH(1), POLK(3), POLL(1), POLM(3), POLQ(11), PRIM1(1), PRIM2(3), REV1(3), REV3L(12)	8384320	54	29	54	26	11	16	8	5	14	0	0.98	1.00
596	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(11), ABCG2(3), BCHE(3), CES1(5), CES2(3), CYP3A4(1), CYP3A5(1), UGT1A5(1)	4548334	32	18	32	18	8	10	9	0	5	0	0.98	1.00
597	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), ST3GAL3(2)	1044316	3	3	3	3	0	3	0	0	0	0	0.98	1.00
598	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), IMPDH1(1), MTHFD2(1), POLD1(4), POLG(1), PRPS2(3), RRM1(4), SRM(1)	2610923	19	11	19	7	4	8	4	2	1	0	0.98	1.00
599	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(2), ARSB(1), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B1(1), HSD11B2(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(1), UGT1A5(1), UGT2B15(1), UGT2B4(2)	5276376	33	22	33	14	8	14	4	1	6	0	0.98	1.00
600	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), NCK1(2), NCKAP1(4), NTRK1(3), WASF1(3), WASF2(2), WASF3(3), WASL(1)	3085467	24	14	24	18	3	14	3	2	2	0	0.99	1.00
601	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1), HADH(2), HADHA(2), HSD17B4(2), NTAN1(2), SIRT1(3), SIRT5(2), VNN2(1)	2356893	15	8	14	8	1	3	5	1	5	0	0.99	1.00
602	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(1), ALDOB(4), ALDOC(2), FBP2(3), FPGT(2), GMDS(1), GMPPA(3), HK1(5), HK2(3), HK3(2), HSD3B7(1), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(1), PFKP(7), PGM2(2), PHPT1(3), PMM1(1), RDH11(1), RDH12(1), TPI1(1), TSTA3(4)	7602014	74	30	74	23	19	34	11	6	4	0	0.99	1.00
603	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(1), GALK2(1), GALT(1), GANAB(2), GCK(2), GLB1(2), HK1(5), HK2(3), HK3(2), LALBA(1), LCT(10), MGAM(4), PFKM(1), PFKP(7), PGM1(2), PGM3(5)	6658645	65	27	64	32	20	26	7	6	6	0	0.99	1.00
604	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(5), RPN1(1), RPN2(2), UBE2A(1), UBE3A(3)	2599884	22	11	22	5	2	4	10	2	4	0	0.99	1.00
605	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(4), ALDOC(2), FBP2(3), G6PD(1), GPI(4), H6PD(1), PFKL(6), PFKM(1), PFKP(7), PGD(1), PGLS(1), PGM1(2), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(3), TALDO1(2), TKTL1(4), TKTL2(3)	4967018	52	23	52	19	14	25	6	4	3	0	0.99	1.00
606	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(2), DHCR24(1), DHCR7(2), EBP(1), FDPS(3), GGCX(1), GGPS1(2), HMGCR(4), HSD17B7(1), MVD(1), MVK(3), NQO1(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(3), TM7SF2(1), VKORC1(1)	3948903	35	17	34	14	8	11	9	3	4	0	0.99	1.00
607	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(5), MAP3K14(1), NFKB1(4), RELA(2), TANK(1), TNFAIP3(4), TRAF2(2), TRAF3(2)	4550994	28	18	28	12	6	14	3	1	4	0	0.99	1.00
608	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASS(1), KARS(2)	945763	4	3	4	4	0	1	3	0	0	0	0.99	1.00
609	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAPN2(3), CAPNS1(1), EP300(10), HDAC1(2), HDAC2(3), MEF2D(3), NFATC2(5), PPP3CA(2), PPP3CB(1)	4930709	41	19	41	12	12	12	9	1	7	0	0.99	1.00
610	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACSL1(2), ACSL3(3), ACSL4(1), CPT1A(2), CPT2(3), EHHADH(1), HADHA(2), SCP2(2), SLC25A20(2)	3383520	20	12	19	5	4	6	3	1	6	0	0.99	1.00
611	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(1), UCHL1(1), UCHL3(3), UGDH(1), UGT1A5(1), UGT2B15(1), UGT2B4(2)	3283770	13	12	13	7	3	4	3	1	2	0	0.99	1.00
612	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(1), EHHADH(1), HADHA(2), HADHB(2), SDS(1)	1683381	10	6	9	4	2	2	1	1	4	0	1.00	1.00
613	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2)	1749349	13	7	13	4	4	1	6	0	2	0	1.00	1.00
614	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1), HADHA(2), SDS(1)	985397	4	2	3	3	2	0	0	0	2	0	1.00	1.00
615	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(4), ALDOC(2), FBP2(3), G6PD(1), GPI(4), H6PD(1), PFKM(1), PFKP(7), PGD(1), PGLS(1), PGM1(2), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(3), TAL1(1), TALDO1(2)	4148536	40	18	40	17	12	18	6	1	3	0	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		100814	0	0	0	0	0	0	0	0	0	0	1.00	1.00
