Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.043 0.041 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.028 0.014 -9999.0 0.0 -0.094 1.0 1.0 SHH Np/Cholesterol/GAS1 0.012 0.039 -9999.0 0.0 -0.138 25.0 25.0 LRPAP1 0.013 0.043 -9999.0 0.0 -0.276 11.0 11.0 dorsoventral neural tube patterning -0.012 0.039 0.137 25.0 -9999.0 0.0 25.0 SMO/beta Arrestin2 0.053 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.012 0.153 -9999.0 0.0 -0.456 39.0 39.0 ARRB2 0.013 0.039 -9999.0 0.0 -0.195 15.0 15.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.018 0.014 -9999.0 0.0 -0.111 6.0 6.0 heart looping 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.035 0.032 -9999.0 0.0 -0.185 2.0 2.0 DHH N/PTCH2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.031 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.223 66.0 66.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.044 0.041 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 skeletal system development 0.044 0.04 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.018 0.014 -9999.0 0.0 -0.111 6.0 6.0 PI3K -0.016 0.093 -9999.0 0.0 -0.211 88.0 88.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.073 -9999.0 0.0 -0.167 78.0 78.0 somite specification 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.043 0.029 -9999.0 0.0 -0.162 1.0 1.0 SHH Np/Cholesterol/PTCH2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.038 0.034 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.051 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.017 0.018 -9999.0 0.0 -0.111 10.0 10.0 receptor-mediated endocytosis 0.05 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.045 0.03 -9999.0 0.0 -0.162 1.0 1.0 IHH N/PTCH2 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.045 0.037 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.022 0.032 -9999.0 0.0 -0.191 10.0 10.0 PTCH2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.038 0.035 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0