PLK1 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations regulation of centriole-centriole cohesion 0.001 0.05 0.259 17.0 -9999.0 0.0 17.0 BUB1B -0.017 0.122 -9999.0 0.0 -0.415 39.0 39.0 PLK1 0.002 0.041 -9999.0 0.0 -0.115 46.0 46.0 PLK1S1 0.002 0.019 -9999.0 0.0 -0.053 44.0 44.0 KIF2A 0.005 0.054 -9999.0 0.0 -0.253 12.0 12.0 regulation of mitotic centrosome separation 0.002 0.041 -9999.0 0.0 -0.115 46.0 46.0 GOLGA2 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 Hec1/SPC24 -0.012 0.094 -9999.0 0.0 -0.313 39.0 39.0 WEE1 -0.003 0.093 -9999.0 0.0 -0.321 30.0 30.0 cytokinesis -0.025 0.163 -9999.0 0.0 -0.521 44.0 44.0 PP2A-alpha B56 -0.059 0.266 -9999.0 0.0 -0.757 62.0 62.0 AURKA -0.002 0.064 -9999.0 0.0 -0.284 23.0 23.0 PICH/PLK1 -0.023 0.178 -9999.0 0.0 -0.473 55.0 55.0 CENPE -0.011 0.096 -9999.0 0.0 -0.325 38.0 38.0 RhoA/GTP 0.004 0.058 -9999.0 0.0 -0.378 12.0 12.0 positive regulation of microtubule depolymerization 0.005 0.054 -9999.0 0.0 -0.251 12.0 12.0 PPP2CA 0.011 0.062 -9999.0 0.0 -0.521 7.0 7.0 FZR1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TPX2 -0.013 0.083 -9999.0 0.0 -0.293 40.0 40.0 PAK1 -0.023 0.127 -9999.0 0.0 -0.376 54.0 54.0 SPC24 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.015 0.035 -9999.0 0.0 -0.432 3.0 3.0 CLSPN 0.002 0.057 -9999.0 0.0 -0.353 11.0 11.0 GORASP1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 metaphase 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NLP 0.002 0.019 -9999.0 0.0 -0.053 44.0 44.0 G2 phase of mitotic cell cycle -0.001 0.003 0.016 1.0 -0.013 21.0 22.0 STAG2 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 GRASP65/GM130/RAB1/GTP 0.021 0.04 -9999.0 0.0 -0.741 1.0 1.0 spindle elongation 0.002 0.041 -9999.0 0.0 -0.115 46.0 46.0 ODF2 0.016 0.024 -9999.0 0.0 -0.53 1.0 1.0 BUB1 -0.102 0.279 -9999.0 0.0 -0.853 60.0 60.0 TPT1 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CDC25C -0.016 0.114 -9999.0 0.0 -0.444 34.0 34.0 CDC25B 0.004 0.069 -9999.0 0.0 -0.302 23.0 23.0 SGOL1 -0.001 0.051 -9999.0 0.0 -0.259 17.0 17.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 CCNB1/CDK1 -0.013 0.153 -9999.0 0.0 -0.483 42.0 42.0 CDC14B 0.01 0.03 -9999.0 0.0 -0.385 3.0 3.0 CDC20 -0.02 0.123 -9999.0 0.0 -0.374 51.0 51.0 PLK1/PBIP1 -0.011 0.083 -9999.0 0.0 -0.243 49.0 49.0 mitosis 0.002 0.007 0.035 21.0 -9999.0 0.0 21.0 FBXO5 0.003 0.054 -9999.0 0.0 -0.26 10.0 10.0 CDC2 -0.012 0.119 -9999.0 0.0 -0.447 34.0 34.0 NDC80 -0.029 0.14 -9999.0 0.0 -0.413 57.0 57.0 metaphase plate congression 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ERCC6L -0.026 0.19 -9999.0 0.0 -0.569 46.0 46.0 NLP/gamma Tubulin 0.005 0.022 -9999.0 0.0 -0.075 5.0 5.0 microtubule cytoskeleton organization 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition DNA damage checkpoint 0.0 0.002 0.01 19.0 -9999.0 0.0 19.0 PPP1R12A 0.015 0.031 -9999.0 0.0 -0.321 4.0 4.0 interphase 0.0 0.002 0.01 19.0 -9999.0 0.0 19.0 PLK1/PRC1-2 -0.017 0.142 -9999.0 0.0 -0.422 48.0 48.0 GRASP65/GM130/RAB1/GTP/PLK1 0.028 0.039 -9999.0 0.0 -0.224 3.0 3.0 RAB1A 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 prophase 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Aurora A/BORA 0.006 0.039 -9999.0 0.0 -0.145 21.0 21.0 mitotic prometaphase -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 proteasomal ubiquitin-dependent protein catabolic process 0.018 0.058 -9999.0 0.0 -0.294 8.0 8.0 microtubule-based process -0.011 0.101 -9999.0 0.0 -0.33 42.0 42.0 Golgi organization 0.002 0.041 -9999.0 0.0 -0.115 46.0 46.0 Cohesin/SA2 0.009 0.036 -9999.0 0.0 -0.121 22.0 22.0 PPP1CB/MYPT1 0.023 0.026 -9999.0 0.0 -0.232 3.0 3.0 KIF20A -0.027 0.143 -9999.0 0.0 -0.461 49.0 49.0 APC/C/CDC20 -0.007 0.089 -9999.0 0.0 -0.282 37.0 37.0 PPP2R1A 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 chromosome segregation -0.011 0.082 -9999.0 0.0 -0.24 49.0 49.0 PRC1 -0.019 0.127 -9999.0 0.0 -0.428 43.0 43.0 ECT2 -0.001 0.07 -9999.0 0.0 -0.312 18.0 18.0 C13orf34 0.006 0.037 -9999.0 0.0 -0.126 21.0 21.0 NUDC 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 regulation of attachment of spindle microtubules to kinetochore -0.016 0.121 -9999.0 0.0 -0.41 39.0 39.0 spindle assembly 0.005 0.031 -9999.0 0.0 -0.093 27.0 27.0 spindle stabilization 0.002 0.019 -9999.0 0.0 -0.053 44.0 44.0 APC/C/HCDH1 0.02 0.025 -9999.0 0.0 -0.316 3.0 3.0 MKLP2/PLK1 -0.011 0.102 -9999.0 0.0 -0.332 42.0 42.0 CCNB1 -0.016 0.13 -9999.0 0.0 -0.496 35.0 35.0 PPP1CB 0.016 0.02 -9999.0 0.0 -0.254 3.0 3.0 BTRC 0.008 0.054 -9999.0 0.0 -0.287 16.0 16.0 ROCK2 0.008 0.055 -9999.0 0.0 -0.337 7.0 7.0 TUBG1 0.008 0.02 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition of mitotic cell cycle -0.046 0.137 -9999.0 0.0 -0.476 41.0 41.0 MLF1IP -0.018 0.101 -9999.0 0.0 -0.32 49.0 49.0 INCENP 0.001 0.081 -9999.0 0.0 -0.366 22.0 22.0