Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 0.01 0.074 -9999.0 0.0 -0.369 18.0 18.0 MAP4K4 -0.003 0.107 -9999.0 0.0 -0.454 12.0 12.0 BAG4 0.002 0.07 -9999.0 0.0 -0.282 28.0 28.0 PKC zeta/ceramide -0.025 0.04 0.129 8.0 -0.116 1.0 9.0 NFKBIA 0.014 0.042 -9999.0 0.0 -0.454 4.0 4.0 BIRC3 -0.085 0.193 -9999.0 0.0 -0.406 128.0 128.0 BAX -0.003 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RIPK1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 AKT1 0.017 0.051 -9999.0 0.0 -0.345 9.0 9.0 BAD -0.018 0.041 0.147 8.0 -0.176 1.0 9.0 SMPD1 0.008 0.06 -9999.0 0.0 -0.235 19.0 19.0 RB1 -0.028 0.07 0.147 8.0 -0.315 20.0 28.0 FADD/Caspase 8 0.007 0.102 -9999.0 0.0 -0.432 11.0 11.0 MAP2K4 -0.043 0.092 0.146 5.0 -0.275 57.0 62.0 NSMAF 0.009 0.065 -9999.0 0.0 -0.441 10.0 10.0 response to UV -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 -0.01 0.04 0.147 8.0 -0.182 1.0 9.0 EGF -0.143 0.226 -9999.0 0.0 -0.423 193.0 193.0 mol:ceramide -0.027 0.044 0.147 9.0 -0.124 1.0 10.0 MADD 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.028 0.13 -9999.0 0.0 -0.38 56.0 56.0 ASAH1 -0.036 0.151 -9999.0 0.0 -0.423 65.0 65.0 negative regulation of cell cycle -0.027 0.069 0.147 8.0 -0.312 20.0 28.0 cell proliferation -0.036 0.097 -9999.0 0.0 -0.234 83.0 83.0 BID -0.013 0.123 -9999.0 0.0 -0.546 17.0 17.0 MAP3K1 -0.041 0.084 0.148 7.0 -0.239 56.0 63.0 EIF2A -0.013 0.059 -9999.0 0.0 -0.257 15.0 15.0 TRADD 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 CRADD 0.01 0.063 -9999.0 0.0 -0.488 8.0 8.0 MAPK3 0.002 0.039 0.156 1.0 -0.189 1.0 2.0 response to heat 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.001 0.04 0.15 8.0 -0.189 1.0 9.0 Cathepsin D/ceramide -0.022 0.055 0.142 7.0 -0.173 23.0 30.0 FADD -0.006 0.106 -9999.0 0.0 -0.38 19.0 19.0 KSR1 -0.017 0.042 0.147 8.0 -0.198 1.0 9.0 MAPK8 -0.03 0.069 0.145 5.0 -0.191 55.0 60.0 PRKRA -0.017 0.042 0.147 8.0 -0.121 1.0 9.0 PDGFA -0.003 0.099 -9999.0 0.0 -0.443 24.0 24.0 TRAF2 0.014 0.042 -9999.0 0.0 -0.454 4.0 4.0 IGF1 -0.101 0.204 -9999.0 0.0 -0.411 146.0 146.0 mol:GD3 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process -0.026 0.044 0.147 9.0 -0.123 1.0 10.0 CTSD 0.002 0.075 -9999.0 0.0 -0.321 24.0 24.0 regulation of nitric oxide biosynthetic process 0.026 0.017 -9999.0 0.0 -0.368 1.0 1.0 response to radiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta -0.035 0.106 -9999.0 0.0 -0.249 83.0 83.0 PRKCD 0.014 0.042 -9999.0 0.0 -0.454 4.0 4.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.028 0.13 -9999.0 0.0 -0.38 56.0 56.0 RelA/NF kappa B1 0.026 0.017 -9999.0 0.0 -0.369 1.0 1.0 mol:glutathione -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.0 0.091 -9999.0 0.0 -0.441 20.0 20.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.005 0.108 -9999.0 0.0 -0.451 13.0 13.0 TNFR1A/BAG4/TNF-alpha 0.012 0.074 -9999.0 0.0 -0.309 18.0 18.0 mol:Sphingosine-1-phosphate 0.01 0.074 -9999.0 0.0 -0.368 18.0 18.0 MAP2K1 -0.002 0.039 -9999.0 0.0 -9999.0 0.0 0.0 mol:C11AG -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYCS 0.027 0.065 0.157 76.0 -9999.0 0.0 76.0 TNFRSF1A 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 NFKB1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 TNFR1A/BAG4 0.014 0.054 -9999.0 0.0 -0.369 5.0 5.0 EIF2AK2 -0.02 0.061 0.147 7.0 -0.261 18.0 25.0 TNF-alpha/TNFR1A/FAN 0.016 0.073 -9999.0 0.0 -0.311 21.0 21.0 response to hydrogen peroxide -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.02 0.062 -9999.0 0.0 -0.296 2.0 2.0 MAP2K2 -0.003 0.043 -9999.0 0.0 -0.27 3.0 3.0 SMPD3 0.005 0.072 -9999.0 0.0 -0.309 13.0 13.0 TNF -0.004 0.094 -9999.0 0.0 -0.357 31.0 31.0 PKC zeta/PAR4 0.001 0.065 -9999.0 0.0 -0.315 20.0 20.0 mol:PHOSPHOCHOLINE 0.055 0.101 0.218 130.0 -9999.0 0.0 130.0 NF kappa B1/RelA/I kappa B alpha 0.03 0.055 -9999.0 0.0 -0.252 18.0 18.0 AIFM1 0.027 0.065 0.157 76.0 -9999.0 0.0 76.0 BCL2 -0.114 0.223 -9999.0 0.0 -0.467 144.0 144.0