BCR signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations JUN -0.061 0.16 -9999.0 0.0 -0.378 78.0 78.0 IKBKB 0.005 0.077 -9999.0 0.0 -0.252 10.0 10.0 AKT1 -0.017 0.098 0.209 10.0 -0.234 37.0 47.0 IKBKG 0.008 0.078 -9999.0 0.0 -0.244 13.0 13.0 CALM1 -0.03 0.128 0.208 11.0 -0.36 46.0 57.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 MAP3K1 -0.075 0.191 -9999.0 0.0 -0.464 73.0 73.0 MAP3K7 0.016 0.02 -9999.0 0.0 -0.254 3.0 3.0 mol:Ca2+ -0.039 0.135 0.21 11.0 -0.37 51.0 62.0 DOK1 0.002 0.083 -9999.0 0.0 -0.409 19.0 19.0 AP-1 -0.045 0.102 0.169 2.0 -0.234 75.0 77.0 LYN 0.014 0.031 -9999.0 0.0 -0.253 7.0 7.0 BLNK -0.012 0.123 -9999.0 0.0 -0.512 30.0 30.0 SHC1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 BCR complex -0.033 0.131 -9999.0 0.0 -0.345 71.0 71.0 CD22 -0.055 0.186 -9999.0 0.0 -0.484 63.0 63.0 CAMK2G -0.022 0.121 0.207 11.0 -0.372 33.0 44.0 CSNK2A1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 -0.057 0.109 -9999.0 0.0 -0.444 21.0 21.0 GO:0007205 -0.04 0.137 0.209 11.0 -0.376 51.0 62.0 SYK -0.023 0.138 -9999.0 0.0 -0.478 43.0 43.0 ELK1 -0.032 0.131 0.208 11.0 -0.365 47.0 58.0 NFATC1 -0.04 0.157 -9999.0 0.0 -0.401 54.0 54.0 B-cell antigen/BCR complex -0.033 0.131 -9999.0 0.0 -0.345 71.0 71.0 PAG1/CSK 0.009 0.074 -9999.0 0.0 -0.366 16.0 16.0 NFKBIB 0.014 0.031 0.097 1.0 -0.108 3.0 4.0 HRAS -0.028 0.126 -9999.0 0.0 -0.336 50.0 50.0 NFKBIA 0.015 0.03 0.097 1.0 -0.112 2.0 3.0 NF-kappa-B/RelA/I kappa B beta 0.02 0.027 0.099 1.0 -0.159 1.0 2.0 RasGAP/Csk -0.026 0.145 -9999.0 0.0 -0.314 77.0 77.0 mol:GDP -0.038 0.131 0.206 11.0 -0.358 51.0 62.0 PTEN -0.002 0.1 -9999.0 0.0 -0.521 19.0 19.0 CD79B -0.042 0.147 -9999.0 0.0 -0.359 84.0 84.0 NF-kappa-B/RelA/I kappa B alpha 0.02 0.027 0.099 1.0 -0.16 1.0 2.0 GRB2 0.016 0.024 -9999.0 0.0 -0.254 4.0 4.0 PI3K/BCAP/CD19 -0.063 0.185 -9999.0 0.0 -0.489 57.0 57.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 mol:IP3 -0.041 0.138 0.211 11.0 -0.38 51.0 62.0 CSK 0.015 0.031 -9999.0 0.0 -0.321 4.0 4.0 FOS -0.078 0.153 -9999.0 0.0 -0.396 63.0 63.0 CHUK 0.001 0.094 -9999.0 0.0 -0.321 20.0 20.0 IBTK 0.016 0.033 -9999.0 0.0 -0.522 2.0 2.0 CARD11/BCL10/MALT1/TAK1 -0.023 0.123 0.201 1.0 -0.386 33.0 34.0 PTPN6 -0.046 0.178 -9999.0 0.0 -0.454 64.0 64.0 RELA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCL2A1 0.013 0.03 -9999.0 0.0 -0.094 11.0 11.0 VAV2 -0.065 0.194 -9999.0 0.0 -0.51 60.0 60.0 ubiquitin-dependent protein catabolic process 0.019 0.03 0.1 1.0 -0.1 3.0 4.0 BTK -0.036 0.199 -9999.0 0.0 -1.091 18.0 18.0 CD19 -0.073 0.196 -9999.0 0.0 -0.438 91.0 91.0 MAP4K1 0.012 0.04 -9999.0 0.0 -0.254 12.0 12.0 CD72 -0.03 0.137 -9999.0 0.0 -0.373 65.0 65.0 PAG1 -0.005 0.097 -9999.0 0.0 -0.379 30.0 30.0 MAPK14 -0.057 0.165 -9999.0 0.0 -0.402 67.0 67.0 SH3BP5 -0.005 0.102 -9999.0 0.0 -0.439 26.0 26.0 PIK3AP1 -0.045 0.159 0.231 11.0 -0.429 53.0 64.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.055 0.187 -9999.0 0.0 -0.464 64.0 64.0 RAF1 -0.02 0.12 -9999.0 0.0 -0.359 33.0 33.0 RasGAP/p62DOK/SHIP -0.036 0.146 -9999.0 0.0 -0.321 79.0 79.0 CD79A -0.011 0.084 -9999.0 0.0 -0.259 54.0 54.0 re-entry into mitotic cell cycle -0.045 0.101 0.171 2.0 -0.233 74.0 76.0 RASA1 0.004 0.078 -9999.0 0.0 -0.421 16.0 16.0 MAPK3 -0.003 0.104 -9999.0 0.0 -0.323 24.0 24.0 MAPK1 -0.003 0.105 -9999.0 0.0 -0.321 26.0 26.0 CD72/SHP1 -0.055 0.193 -9999.0 0.0 -0.502 62.0 62.0 NFKB1 0.017 0.023 -9999.0 0.0 -0.522 1.0 1.0 MAPK8 -0.058 0.166 -9999.0 0.0 -0.407 66.0 66.0 actin cytoskeleton organization -0.049 0.167 -9999.0 0.0 -0.468 49.0 49.0 NF-kappa-B/RelA 0.043 0.054 0.191 1.0 -0.231 3.0 4.0 Calcineurin -0.023 0.123 -9999.0 0.0 -0.365 36.0 36.0 PI3K -0.087 0.143 -9999.0 0.0 -0.393 70.0 70.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.043 0.148 0.235 11.0 -0.418 48.0 59.0 SOS1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 Bam32/HPK1 -0.132 0.307 -9999.0 0.0 -0.749 96.0 96.0 DAPP1 -0.158 0.348 -9999.0 0.0 -0.864 95.0 95.0 cytokine secretion -0.037 0.147 -9999.0 0.0 -0.373 54.0 54.0 mol:DAG -0.041 0.138 0.211 11.0 -0.38 51.0 62.0 PLCG2 -0.017 0.108 -9999.0 0.0 -0.317 55.0 55.0 MAP2K1 -0.011 0.112 -9999.0 0.0 -0.347 28.0 28.0 B-cell antigen/BCR complex/FcgammaRIIB -0.045 0.151 -9999.0 0.0 -0.323 106.0 106.0 mol:PI-3-4-5-P3 -0.058 0.113 0.25 13.0 -0.29 63.0 76.0 ETS1 -0.019 0.121 -9999.0 0.0 -0.36 35.0 35.0 B-cell antigen/BCR complex/LYN/SYK/BLNK -0.031 0.149 -9999.0 0.0 -0.308 86.0 86.0 B-cell antigen/BCR complex/LYN -0.077 0.176 -9999.0 0.0 -0.502 57.0 57.0 MALT1 0.011 0.053 -9999.0 0.0 -0.373 9.0 9.0 TRAF6 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 RAC1 -0.053 0.178 -9999.0 0.0 -0.507 48.0 48.0 B-cell antigen/BCR complex/LYN/SYK -0.053 0.191 -9999.0 0.0 -0.506 59.0 59.0 CARD11 -0.038 0.143 0.208 11.0 -0.373 55.0 66.0 FCGR2B -0.031 0.152 -9999.0 0.0 -0.495 50.0 50.0 PPP3CA 0.006 0.073 -9999.0 0.0 -0.439 13.0 13.0 BCL10 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 IKK complex 0.012 0.04 0.112 1.0 -0.11 8.0 9.0 PTPRC -0.04 0.154 -9999.0 0.0 -0.412 71.0 71.0 PDPK1 -0.017 0.091 0.197 9.0 -0.228 34.0 43.0 PPP3CB 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 PPP3CC -0.001 0.098 -9999.0 0.0 -0.507 19.0 19.0 POU2F2 0.019 0.021 -9999.0 0.0 -0.098 1.0 1.0