Arf6 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CENTA1/KIF3B 0.0 0.058 -9999.0 0.0 -0.257 23.0 23.0 ARNO/beta Arrestin1-2 -0.013 0.089 -9999.0 0.0 -0.245 56.0 56.0 EGFR -0.079 0.175 -9999.0 0.0 -0.35 139.0 139.0 EPHA2 0.008 0.059 -9999.0 0.0 -0.33 14.0 14.0 USP6 0.012 0.04 -9999.0 0.0 -0.254 12.0 12.0 IQSEC1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 EGFR/EGFR/EGF/EGF -0.153 0.202 -9999.0 0.0 -0.418 173.0 173.0 ARRB2 0.011 0.052 -9999.0 0.0 -0.322 12.0 12.0 mol:GTP 0.006 0.015 0.063 11.0 -0.092 5.0 16.0 ARRB1 0.004 0.075 -9999.0 0.0 -0.373 18.0 18.0 FBXO8 0.015 0.04 -9999.0 0.0 -0.521 3.0 3.0 TSHR 0.008 0.071 -9999.0 0.0 -0.495 10.0 10.0 EGF -0.143 0.226 -9999.0 0.0 -0.423 193.0 193.0 somatostatin receptor activity -0.0 0.0 -9999.0 0.0 -0.001 98.0 98.0 ARAP2 -0.0 0.0 -9999.0 0.0 -0.0 110.0 110.0 mol:GDP -0.054 0.106 -9999.0 0.0 -0.249 90.0 90.0 mol:PI-3-4-5-P3 -0.0 0.0 -9999.0 0.0 -0.001 102.0 102.0 ITGA2B 0.016 0.02 -9999.0 0.0 -0.254 3.0 3.0 ARF6 0.016 0.033 -9999.0 0.0 -0.522 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.071 -9999.0 0.0 -0.27 24.0 24.0 ADAP1 -0.0 0.0 -9999.0 0.0 -0.0 87.0 87.0 KIF13B -0.002 0.095 -9999.0 0.0 -0.428 23.0 23.0 HGF/MET 0.007 0.073 -9999.0 0.0 -0.376 13.0 13.0 PXN 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.067 0.113 -9999.0 0.0 -0.266 96.0 96.0 EGFR/EGFR/EGF/EGF/ARFGEP100 -0.12 0.177 -9999.0 0.0 -0.352 173.0 173.0 ADRB2 -0.045 0.158 -9999.0 0.0 -0.398 80.0 80.0 receptor agonist activity -0.0 0.0 -9999.0 0.0 -0.0 96.0 96.0 actin filament binding -0.0 0.0 -9999.0 0.0 -0.0 98.0 98.0 SRC 0.015 0.035 -9999.0 0.0 -0.432 3.0 3.0 ITGB3 0.002 0.075 -9999.0 0.0 -0.318 25.0 25.0 GNAQ -0.0 0.0 -9999.0 0.0 -0.001 91.0 91.0 EFA6/PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -0.001 92.0 92.0 ARF6/GDP -0.003 0.059 -9999.0 0.0 -0.238 10.0 10.0 ARF6/GDP/GULP/ACAP1 -0.058 0.133 -9999.0 0.0 -0.305 93.0 93.0 alphaIIb/beta3 Integrin/paxillin/GIT1 0.034 0.048 -9999.0 0.0 -0.263 8.0 8.0 ACAP1 -0.0 0.0 -9999.0 0.0 -0.0 18.0 18.0 ACAP2 -0.0 0.0 -9999.0 0.0 -0.0 105.0 105.0 LHCGR/beta Arrestin2 0.009 0.07 -9999.0 0.0 -0.441 12.0 12.0 EFNA1 0.0 0.094 -9999.0 0.0 -0.492 18.0 18.0 HGF 0.008 0.069 -9999.0 0.0 -0.449 11.0 11.0 CYTH3 -0.0 0.0 -9999.0 0.0 -0.001 97.0 97.0 CYTH2 -0.001 0.002 -9999.0 0.0 -0.004 102.0 102.0 NCK1 0.011 0.045 -9999.0 0.0 -0.276 12.0 12.0 fibronectin binding -0.0 0.0 -9999.0 0.0 -0.0 83.0 83.0 endosomal lumen acidification -0.0 0.0 -9999.0 0.0 -0.0 86.0 86.0 microtubule-based process 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GULP1 -0.035 0.152 -9999.0 0.0 -0.438 61.0 61.0 GNAQ/ARNO -0.001 0.003 -9999.0 0.0 -0.006 91.0 91.0 mol:Phosphatidic acid -0.0 0.0 -9999.0 0.0 -0.0 105.0 105.0 PIP3-E 0.004 0.068 -9999.0 0.0 -0.3 23.0 23.0 MET -0.0 0.075 -9999.0 0.0 -0.288 31.0 31.0 GNA14 -0.08 0.175 -9999.0 0.0 -0.349 140.0 140.0 GNA15 0.002 0.076 -9999.0 0.0 -0.335 23.0 23.0 GIT1 0.014 0.035 -9999.0 0.0 -0.298 6.0 6.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -0.001 93.0 93.0 GNA11 0.013 0.047 -9999.0 0.0 -0.522 4.0 4.0 LHCGR 0.003 0.083 -9999.0 0.0 -0.455 16.0 16.0 AGTR1 -0.148 0.207 -9999.0 0.0 -0.362 231.0 231.0 desensitization of G-protein coupled receptor protein signaling pathway 0.009 0.07 -9999.0 0.0 -0.44 12.0 12.0 IPCEF1/ARNO -0.095 0.142 -9999.0 0.0 -0.276 179.0 179.0 alphaIIb/beta3 Integrin 0.014 0.056 -9999.0 0.0 -0.362 7.0 7.0