IGF1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations NCK2 0.015 0.026 -9999.0 0.0 -0.254 5.0 5.0 PTK2 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 CRKL -0.105 0.191 -9999.0 0.0 -0.368 154.0 154.0 GRB2/SOS1/SHC 0.034 0.025 -9999.0 0.0 -0.305 2.0 2.0 HRAS 0.012 0.051 -9999.0 0.0 -0.407 7.0 7.0 IRS1/Crk -0.104 0.191 -9999.0 0.0 -0.365 154.0 154.0 IGF-1R heterotetramer/IGF1/PTP1B -0.108 0.184 -9999.0 0.0 -0.366 155.0 155.0 AKT1 -0.086 0.177 -9999.0 0.0 -0.425 84.0 84.0 BAD -0.075 0.167 -9999.0 0.0 -0.394 84.0 84.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.104 0.19 -9999.0 0.0 -0.364 154.0 154.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.103 0.193 -9999.0 0.0 -0.369 152.0 152.0 RAF1 -0.063 0.161 -9999.0 0.0 -0.395 69.0 69.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.088 0.188 -9999.0 0.0 -0.345 153.0 153.0 YWHAZ 0.017 0.017 -9999.0 0.0 -0.254 2.0 2.0 IGF-1R heterotetramer/IGF1/IRS1 -0.119 0.204 -9999.0 0.0 -0.381 169.0 169.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 RPS6KB1 -0.086 0.176 -9999.0 0.0 -0.424 84.0 84.0 GNB2L1 0.015 0.04 -9999.0 0.0 -0.521 3.0 3.0 positive regulation of MAPKKK cascade -0.058 0.139 -9999.0 0.0 -0.342 69.0 69.0 PXN 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1 0.024 0.023 -9999.0 0.0 -0.369 1.0 1.0 HRAS/GTP -0.099 0.154 -9999.0 0.0 -0.427 73.0 73.0 IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.06 0.154 -9999.0 0.0 -0.35 71.0 71.0 IGF-1R heterotetramer -0.105 0.218 -9999.0 0.0 -0.511 110.0 110.0 IGF-1R heterotetramer/IGF1/IRS/Nck -0.102 0.194 -9999.0 0.0 -0.37 152.0 152.0 Crk/p130 Cas/Paxillin -0.078 0.179 -9999.0 0.0 -0.322 154.0 154.0 IGF1R -0.105 0.218 -9999.0 0.0 -0.512 110.0 110.0 IGF1 -0.12 0.215 -9999.0 0.0 -0.439 146.0 146.0 IRS2/Crk -0.112 0.201 -9999.0 0.0 -0.363 166.0 166.0 PI3K -0.101 0.197 -9999.0 0.0 -0.355 164.0 164.0 apoptosis 0.057 0.148 0.351 75.0 -9999.0 0.0 75.0 HRAS/GDP 0.009 0.036 -9999.0 0.0 -0.288 7.0 7.0 PRKCD -0.096 0.211 -9999.0 0.0 -0.436 117.0 117.0 RAF1/14-3-3 E -0.048 0.143 -9999.0 0.0 -0.339 68.0 68.0 BAD/14-3-3 -0.061 0.157 -9999.0 0.0 -0.374 75.0 75.0 PRKCZ -0.09 0.175 -9999.0 0.0 -0.41 91.0 91.0 Crk/p130 Cas/Paxillin/FAK1 -0.087 0.135 -9999.0 0.0 -0.387 67.0 67.0 PTPN1 0.002 0.07 -9999.0 0.0 -0.282 28.0 28.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.107 0.219 -9999.0 0.0 -0.412 153.0 153.0 BCAR1 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.086 0.171 -9999.0 0.0 -0.318 163.0 163.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOS1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 IRS1/NCK2 -0.103 0.192 -9999.0 0.0 -0.367 152.0 152.0 GRB10 -0.003 0.097 -9999.0 0.0 -0.432 24.0 24.0 PTPN11 -0.104 0.191 -9999.0 0.0 -0.367 152.0 152.0 IRS1 -0.12 0.203 -9999.0 0.0 -0.38 169.0 169.0 IRS2 -0.125 0.209 -9999.0 0.0 -0.388 165.0 165.0 IGF-1R heterotetramer/IGF1 -0.143 0.224 -9999.0 0.0 -0.466 153.0 153.0 GRB2 0.016 0.024 -9999.0 0.0 -0.254 4.0 4.0 PDPK1 -0.094 0.185 -9999.0 0.0 -0.431 91.0 91.0 YWHAE 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 PRKD1 -0.116 0.229 -9999.0 0.0 -0.42 155.0 155.0 SHC1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0