Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.101 0.257 -9999.0 0.0 -0.623 82.0 82.0 IHH -0.014 0.093 -9999.0 0.0 -0.482 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.289 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.055 0.172 -9999.0 0.0 -0.471 49.0 49.0 SMO -0.066 0.18 -9999.0 0.0 -0.488 53.0 53.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.505 22.0 22.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.02 0.124 -9999.0 0.0 -0.382 50.0 50.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.178 -9999.0 0.0 -0.481 53.0 53.0 STIL -0.052 0.148 -9999.0 0.0 -0.372 52.0 52.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.028 0.126 -9999.0 0.0 -0.368 24.0 24.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.121 0.312 -9999.0 0.0 -0.834 66.0 66.0 determination of left/right symmetry -0.065 0.178 -9999.0 0.0 -0.481 53.0 53.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 skeletal system development -0.119 0.308 -9999.0 0.0 -0.822 66.0 66.0 IHH N/Hhip 0.004 0.068 -9999.0 0.0 -0.315 18.0 18.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.178 -9999.0 0.0 -0.481 53.0 53.0 pancreas development 0.011 0.052 -9999.0 0.0 -0.326 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.005 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.065 0.178 -9999.0 0.0 -0.481 53.0 53.0 SHH Np/Cholesterol/PTCH1 -0.049 0.143 -9999.0 0.0 -0.358 49.0 49.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.276 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.334 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.142 -9999.0 0.0 -0.33 76.0 76.0 SMO/Vitamin D3 -0.061 0.167 -9999.0 0.0 -0.404 63.0 63.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.278 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.483 183.0 183.0 receptor-mediated endocytosis -0.12 0.198 -9999.0 0.0 -0.471 84.0 84.0 SHH Np/Cholesterol/BOC -0.027 0.116 -9999.0 0.0 -0.283 85.0 85.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.047 0.145 -9999.0 0.0 -0.358 49.0 49.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.412 27.0 27.0 IHH N/PTCH1 -0.04 0.145 -9999.0 0.0 -0.332 76.0 76.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.043 0.143 -9999.0 0.0 -0.331 76.0 76.0 HHIP 0.011 0.052 -9999.0 0.0 -0.327 11.0 11.0