Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.127 -9999.0 0.0 -0.255 110.0 110.0 epithelial cell differentiation -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 CYFIP2 -0.042 0.164 -9999.0 0.0 -0.468 65.0 65.0 ENAH 0.012 0.096 -9999.0 0.0 -0.314 14.0 14.0 EGFR -0.079 0.175 -9999.0 0.0 -0.35 139.0 139.0 EPHA2 0.008 0.059 -9999.0 0.0 -0.33 14.0 14.0 MYO6 -0.012 0.111 -9999.0 0.0 -0.248 90.0 90.0 CTNNB1 0.001 0.09 -9999.0 0.0 -0.451 19.0 19.0 ABI1/Sra1/Nap1 -0.004 0.106 -9999.0 0.0 -0.31 53.0 53.0 AQP5 -0.086 0.191 -9999.0 0.0 -0.439 99.0 99.0 CTNND1 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 mol:PI-4-5-P2 -0.004 0.1 -9999.0 0.0 -0.239 78.0 78.0 regulation of calcium-dependent cell-cell adhesion -0.014 0.105 -9999.0 0.0 -0.245 82.0 82.0 EGF -0.143 0.226 -9999.0 0.0 -0.423 193.0 193.0 NCKAP1 0.015 0.031 -9999.0 0.0 -0.321 4.0 4.0 AQP3 -0.088 0.201 -9999.0 0.0 -0.468 96.0 96.0 cortical microtubule organization -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 GO:0000145 -0.006 0.095 -9999.0 0.0 -0.228 78.0 78.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.107 -9999.0 0.0 -0.259 76.0 76.0 MLLT4 -0.006 0.106 -9999.0 0.0 -0.46 26.0 26.0 ARF6/GDP -0.04 0.086 -9999.0 0.0 -0.388 12.0 12.0 ARF6 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.071 -9999.0 0.0 -0.27 24.0 24.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.006 0.123 -9999.0 0.0 -0.45 14.0 14.0 PVRL2 0.002 0.089 -9999.0 0.0 -0.521 15.0 15.0 ZYX -0.009 0.106 -9999.0 0.0 -0.245 84.0 84.0 ARF6/GTP 0.03 0.072 -9999.0 0.0 -0.272 22.0 22.0 CDH1 -0.049 0.173 -9999.0 0.0 -0.483 70.0 70.0 EGFR/EGFR/EGF/EGF -0.135 0.145 -9999.0 0.0 -0.376 92.0 92.0 RhoA/GDP -0.01 0.107 -9999.0 0.0 -0.247 85.0 85.0 actin cytoskeleton organization -0.007 0.107 -9999.0 0.0 -0.238 76.0 76.0 IGF-1R heterotetramer -0.083 0.203 -9999.0 0.0 -0.467 110.0 110.0 GIT1 0.014 0.035 -9999.0 0.0 -0.298 6.0 6.0 IGF1R -0.083 0.203 -9999.0 0.0 -0.468 110.0 110.0 IGF1 -0.101 0.204 -9999.0 0.0 -0.411 146.0 146.0 DIAPH1 -0.055 0.177 -9999.0 0.0 -0.583 53.0 53.0 Wnt receptor signaling pathway 0.007 0.104 0.256 76.0 -9999.0 0.0 76.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 RhoA/GTP -0.044 0.089 -9999.0 0.0 -0.366 16.0 16.0 CTNNA1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 VCL -0.007 0.109 -9999.0 0.0 -0.243 76.0 76.0 EFNA1 0.0 0.094 -9999.0 0.0 -0.492 18.0 18.0 LPP -0.003 0.105 -9999.0 0.0 -0.376 8.0 8.0 Ephrin A1/EPHA2 -0.044 0.094 -9999.0 0.0 -0.43 8.0 8.0 SEC6/SEC8 -0.045 0.092 -9999.0 0.0 -0.41 10.0 10.0 MGAT3 -0.014 0.107 -9999.0 0.0 -0.248 82.0 82.0 HGF/MET -0.044 0.089 -9999.0 0.0 -0.342 10.0 10.0 HGF 0.008 0.069 -9999.0 0.0 -0.448 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.128 -9999.0 0.0 -0.257 110.0 110.0 actin cable formation 0.017 0.1 -9999.0 0.0 -0.281 21.0 21.0 KIAA1543 0.001 0.103 -9999.0 0.0 -0.376 9.0 9.0 KIFC3 -0.005 0.1 -9999.0 0.0 -0.239 77.0 77.0 NCK1 0.011 0.045 -9999.0 0.0 -0.276 12.0 12.0 EXOC3 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 ACTN1 -0.009 0.107 -9999.0 0.0 -0.244 85.0 85.0 NCK1/GIT1 0.019 0.042 -9999.0 0.0 -0.439 2.0 2.0 mol:GDP -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 EXOC4 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 STX4 -0.003 0.101 -9999.0 0.0 -0.242 76.0 76.0 PIP5K1C -0.004 0.102 -9999.0 0.0 -0.242 78.0 78.0 LIMA1 -0.024 0.144 -9999.0 0.0 -0.521 41.0 41.0 ABI1 0.016 0.02 -9999.0 0.0 -0.254 3.0 3.0 ROCK1 0.009 0.102 -9999.0 0.0 -0.318 16.0 16.0 adherens junction assembly 0.012 0.107 -9999.0 0.0 -0.437 8.0 8.0 IGF-1R heterotetramer/IGF1 -0.123 0.155 -9999.0 0.0 -0.295 203.0 203.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.103 -9999.0 0.0 -0.388 33.0 33.0 MET -0.0 0.075 -9999.0 0.0 -0.288 31.0 31.0 PLEKHA7 -0.003 0.099 -9999.0 0.0 -0.239 77.0 77.0 mol:GTP 0.024 0.07 -9999.0 0.0 -0.269 24.0 24.0 establishment of epithelial cell apical/basal polarity 0.006 0.113 -9999.0 0.0 -0.409 10.0 10.0 cortical actin cytoskeleton stabilization -0.027 0.127 -9999.0 0.0 -0.255 110.0 110.0 regulation of cell-cell adhesion -0.007 0.107 -9999.0 0.0 -0.238 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.128 -9999.0 0.0 -0.257 110.0 110.0