IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.026 0.03 -9999.0 0.0 -0.458 2.0 2.0 CD4-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.17 0.26 0.614 101.0 -9999.0 0.0 101.0 IL27/IL27R/JAK1 -0.201 0.353 -9999.0 0.0 -0.912 75.0 75.0 TBX21 -0.217 0.298 -9999.0 0.0 -0.615 151.0 151.0 IL12B 0.001 0.075 -9999.0 0.0 -0.346 21.0 21.0 IL12A -0.01 0.064 -9999.0 0.0 -0.19 55.0 55.0 IL6ST -0.119 0.223 -9999.0 0.0 -0.471 143.0 143.0 IL27RA/JAK1 -0.107 0.327 -9999.0 0.0 -1.228 39.0 39.0 IL27 -0.082 0.201 -9999.0 0.0 -0.495 98.0 98.0 TYK2 0.011 0.011 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.006 0.113 -9999.0 0.0 -1.358 1.0 1.0 T-helper 2 cell differentiation 0.17 0.26 0.614 101.0 -9999.0 0.0 101.0 T cell proliferation during immune response 0.17 0.26 0.614 101.0 -9999.0 0.0 101.0 MAPKKK cascade -0.17 0.26 -9999.0 0.0 -0.614 101.0 101.0 STAT3 0.015 0.04 -9999.0 0.0 -0.521 3.0 3.0 STAT2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 -0.021 0.116 -9999.0 0.0 -0.33 58.0 58.0 IL12RB1 0.017 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of tyrosine phosphorylation of STAT protein 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.211 0.282 -9999.0 0.0 -0.594 145.0 145.0 IL27/IL27R/JAK2/TYK2 -0.172 0.266 -9999.0 0.0 -0.625 101.0 101.0 positive regulation of T cell mediated cytotoxicity -0.17 0.26 -9999.0 0.0 -0.614 101.0 101.0 STAT1 (dimer) -0.271 0.395 0.481 7.0 -0.922 101.0 108.0 JAK2 0.004 0.055 -9999.0 0.0 -0.333 12.0 12.0 JAK1 0.011 0.057 -9999.0 0.0 -0.523 6.0 6.0 STAT2 (dimer) -0.155 0.252 -9999.0 0.0 -0.611 92.0 92.0 T cell proliferation -0.198 0.271 -9999.0 0.0 -0.613 117.0 117.0 IL12/IL12R/TYK2/JAK2 -0.033 0.147 -9999.0 0.0 -0.901 8.0 8.0 IL17A -0.006 0.114 -9999.0 0.0 -1.364 1.0 1.0 mast cell activation 0.17 0.26 0.614 101.0 -9999.0 0.0 101.0 IFNG -0.031 0.047 -9999.0 0.0 -0.107 97.0 97.0 T cell differentiation -0.01 0.009 0.024 1.0 -0.022 159.0 160.0 STAT3 (dimer) -0.157 0.253 -9999.0 0.0 -0.606 95.0 95.0 STAT5A (dimer) -0.158 0.256 -9999.0 0.0 -0.617 94.0 94.0 STAT4 (dimer) -0.174 0.27 -9999.0 0.0 -0.61 112.0 112.0 STAT4 -0.024 0.134 -9999.0 0.0 -0.42 50.0 50.0 T cell activation 0.002 0.038 0.083 77.0 -9999.0 0.0 77.0 IL27R/JAK2/TYK2 -0.162 0.332 -9999.0 0.0 -0.982 57.0 57.0 GATA3 -0.252 0.549 -9999.0 0.0 -1.267 119.0 119.0 IL18 -0.035 0.121 -9999.0 0.0 -0.316 76.0 76.0 positive regulation of mast cell cytokine production -0.154 0.246 -9999.0 0.0 -0.591 95.0 95.0 IL27/EBI3 -0.06 0.155 -9999.0 0.0 -0.385 93.0 93.0 IL27RA -0.12 0.342 -9999.0 0.0 -1.317 38.0 38.0 IL6 -0.077 0.183 -9999.0 0.0 -0.511 59.0 59.0 STAT5A 0.011 0.056 -9999.0 0.0 -0.421 8.0 8.0 monocyte differentiation -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.054 0.161 0.494 38.0 -1.158 3.0 41.0 IL1B -0.033 0.115 -9999.0 0.0 -0.286 81.0 81.0 EBI3 0.002 0.071 -9999.0 0.0 -0.442 12.0 12.0 TNF -0.003 0.067 -9999.0 0.0 -0.251 31.0 31.0