Insulin Pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CBL/APS/CAP -0.048 0.101 -9999.0 0.0 -0.258 87.0 87.0 TC10/GTP -0.022 0.063 -9999.0 0.0 -0.232 39.0 39.0 Insulin Receptor/Insulin/IRS1/Shp2 0.005 0.11 -9999.0 0.0 -0.286 63.0 63.0 HRAS 0.012 0.051 -9999.0 0.0 -0.407 7.0 7.0 APS homodimer -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB14 -0.16 0.21 -9999.0 0.0 -0.363 247.0 247.0 FOXO3 -0.021 0.065 -9999.0 0.0 -0.707 4.0 4.0 AKT1 -0.068 0.136 -9999.0 0.0 -0.366 44.0 44.0 INSR 0.015 0.038 -9999.0 0.0 -0.382 4.0 4.0 Insulin Receptor/Insulin 0.036 0.079 -9999.0 0.0 -0.487 4.0 4.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB10 -0.003 0.097 -9999.0 0.0 -0.432 24.0 24.0 SORBS1 -0.032 0.142 -9999.0 0.0 -0.39 65.0 65.0 CRK 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 PTPN1 0.023 0.075 -9999.0 0.0 -0.481 4.0 4.0 CAV1 -0.012 0.108 -9999.0 0.0 -0.273 69.0 69.0 CBL/APS/CAP/Crk-II/C3G 0.014 0.078 -9999.0 0.0 -0.253 35.0 35.0 Insulin Receptor/Insulin/IRS1/NCK2 0.004 0.111 -9999.0 0.0 -0.29 62.0 62.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.108 -9999.0 0.0 -0.254 80.0 80.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.013 0.09 -9999.0 0.0 -0.461 6.0 6.0 RPS6KB1 -0.06 0.128 -9999.0 0.0 -0.327 50.0 50.0 PARD6A 0.004 0.081 -9999.0 0.0 -0.438 16.0 16.0 CBL 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 tumor necrosis factor-mediated signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DOK1 -0.014 0.114 -9999.0 0.0 -0.779 11.0 11.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.082 0.106 -9999.0 0.0 -0.333 47.0 47.0 HRAS/GTP -0.028 0.073 -9999.0 0.0 -0.332 7.0 7.0 Insulin Receptor 0.015 0.037 -9999.0 0.0 -0.382 4.0 4.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.014 0.104 -9999.0 0.0 -0.259 63.0 63.0 PRKCI -0.033 0.104 -9999.0 0.0 -0.515 21.0 21.0 Insulin Receptor/Insulin/GRB14/PDK1 -0.098 0.122 -9999.0 0.0 -0.386 43.0 43.0 SHC1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 negative regulation of MAPKKK cascade 0.009 0.115 -9999.0 0.0 -0.668 12.0 12.0 PI3K -0.005 0.112 -9999.0 0.0 -0.257 80.0 80.0 NCK2 0.015 0.026 -9999.0 0.0 -0.254 5.0 5.0 RHOQ 0.012 0.053 -9999.0 0.0 -0.477 6.0 6.0 mol:H2O2 -0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.009 0.036 -9999.0 0.0 -0.288 7.0 7.0 AKT2 -0.065 0.134 -9999.0 0.0 -0.36 42.0 42.0 PRKCZ -0.028 0.074 -9999.0 0.0 -0.534 9.0 9.0 SH2B2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/SHIP -0.002 0.093 -9999.0 0.0 -0.249 63.0 63.0 F2RL2 -0.074 0.192 -9999.0 0.0 -0.445 105.0 105.0 TRIP10 0.013 0.048 -9999.0 0.0 -0.468 5.0 5.0 Insulin Receptor/Insulin/Shc 0.032 0.029 -9999.0 0.0 -0.269 4.0 4.0 TC10/GTP/CIP4/Exocyst 0.018 0.045 -9999.0 0.0 -0.313 9.0 9.0 Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.05 0.036 -9999.0 0.0 -0.304 4.0 4.0 RAPGEF1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.004 0.078 -9999.0 0.0 -0.421 16.0 16.0 NCK1 0.011 0.045 -9999.0 0.0 -0.276 12.0 12.0 CBL/APS/CAP/Crk-II 0.005 0.082 -9999.0 0.0 -0.276 35.0 35.0 TC10/GDP 0.009 0.039 -9999.0 0.0 -0.343 6.0 6.0 Insulin Receptor/Insulin/SHC/GRB10 0.032 0.064 -9999.0 0.0 -0.274 20.0 20.0 INPP5D -0.014 0.096 -9999.0 0.0 -0.27 62.0 62.0 SOS1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 SGK1 -0.01 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:cAMP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 IRS1 -0.048 0.174 -9999.0 0.0 -0.494 68.0 68.0 p62DOK/RasGAP 0.009 0.116 -9999.0 0.0 -0.678 12.0 12.0 INS 0.017 0.025 -9999.0 0.0 -0.518 1.0 1.0 mol:PI-3-4-P2 -0.013 0.096 -9999.0 0.0 -0.268 62.0 62.0 GRB2 0.016 0.024 -9999.0 0.0 -0.254 4.0 4.0 EIF4EBP1 -0.067 0.134 -9999.0 0.0 -0.341 57.0 57.0 PTPRA 0.017 0.028 -9999.0 0.0 -0.402 2.0 2.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 TC10/GTP/CIP4 0.018 0.045 -9999.0 0.0 -0.313 9.0 9.0 PDPK1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.009 0.095 -9999.0 0.0 -0.373 7.0 7.0 Insulin Receptor/Insulin/IRS1 -0.006 0.107 -9999.0 0.0 -0.292 62.0 62.0 Insulin Receptor/Insulin/IRS3 0.024 0.034 -9999.0 0.0 -0.366 3.0 3.0 Par3/Par6 -0.02 0.126 -9999.0 0.0 -0.286 86.0 86.0