Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.147 0.206 -9999.0 0.0 -0.425 156.0 156.0 CRKL -0.16 0.218 -9999.0 0.0 -0.452 160.0 160.0 HRAS -0.116 0.191 -9999.0 0.0 -0.379 143.0 143.0 mol:PIP3 -0.153 0.2 -9999.0 0.0 -0.432 149.0 149.0 SPRED1 -0.002 0.098 -9999.0 0.0 -0.47 21.0 21.0 SPRED2 -0.003 0.101 -9999.0 0.0 -0.496 21.0 21.0 GAB1 -0.173 0.228 -9999.0 0.0 -0.473 165.0 165.0 FOXO3 -0.144 0.201 -9999.0 0.0 -0.42 151.0 151.0 AKT1 -0.159 0.213 -9999.0 0.0 -0.45 153.0 153.0 BAD -0.142 0.198 -9999.0 0.0 -0.414 150.0 150.0 megakaryocyte differentiation -0.173 0.227 -9999.0 0.0 -0.474 163.0 163.0 GSK3B -0.141 0.198 -9999.0 0.0 -0.414 150.0 150.0 RAF1 -0.088 0.159 -9999.0 0.0 -0.334 91.0 91.0 SHC1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 STAT3 -0.169 0.224 -9999.0 0.0 -0.47 160.0 160.0 STAT1 -0.369 0.486 -9999.0 0.0 -1.026 160.0 160.0 HRAS/SPRED1 -0.095 0.166 -9999.0 0.0 -0.348 101.0 101.0 cell proliferation -0.166 0.218 -9999.0 0.0 -0.457 162.0 162.0 PIK3CA 0.015 0.029 -9999.0 0.0 -0.344 3.0 3.0 TEC 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 RPS6KB1 -0.171 0.225 -9999.0 0.0 -0.47 163.0 163.0 HRAS/SPRED2 -0.095 0.166 -9999.0 0.0 -0.352 94.0 94.0 LYN/TEC/p62DOK -0.153 0.223 -9999.0 0.0 -0.461 151.0 151.0 MAPK3 -0.053 0.119 -9999.0 0.0 -0.259 54.0 54.0 STAP1 -0.191 0.235 -9999.0 0.0 -0.49 170.0 170.0 GRAP2 0.012 0.042 -9999.0 0.0 -0.28 10.0 10.0 JAK2 -0.308 0.403 -9999.0 0.0 -0.847 162.0 162.0 STAT1 (dimer) -0.359 0.472 -9999.0 0.0 -0.972 170.0 170.0 mol:Gleevec 0.005 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.158 0.226 -9999.0 0.0 -0.457 160.0 160.0 actin filament polymerization -0.171 0.217 -9999.0 0.0 -0.46 163.0 163.0 LYN 0.014 0.031 -9999.0 0.0 -0.254 7.0 7.0 STAP1/STAT5A (dimer) -0.239 0.306 -9999.0 0.0 -0.642 164.0 164.0 PIK3R1 -0.01 0.11 -9999.0 0.0 -0.417 33.0 33.0 CBL/CRKL/GRB2 -0.132 0.202 -9999.0 0.0 -0.414 146.0 146.0 PI3K -0.162 0.229 -9999.0 0.0 -0.465 158.0 158.0 PTEN -0.001 0.1 -9999.0 0.0 -0.521 19.0 19.0 SCF/KIT/EPO/EPOR -0.389 0.542 -9999.0 0.0 -1.252 127.0 127.0 MAPK8 -0.169 0.222 -9999.0 0.0 -0.467 162.0 162.0 STAT3 (dimer) -0.166 0.219 -9999.0 0.0 -0.46 160.0 160.0 positive regulation of transcription -0.042 0.101 -9999.0 0.0 -0.212 53.0 53.0 mol:GDP -0.124 0.2 -9999.0 0.0 -0.399 147.0 147.0 PIK3C2B -0.17 0.224 -9999.0 0.0 -0.471 161.0 161.0 CBL/CRKL -0.143 0.207 -9999.0 0.0 -0.426 153.0 153.0 FER -0.169 0.223 -9999.0 0.0 -0.47 160.0 160.0 SH2B3 -0.168 0.223 -9999.0 0.0 -0.469 160.0 160.0 PDPK1 -0.137 0.185 -9999.0 0.0 -0.404 140.0 140.0 SNAI2 -0.194 0.248 -9999.0 0.0 -0.506 174.0 174.0 positive regulation of cell proliferation -0.272 0.358 -9999.0 0.0 -0.741 167.0 167.0 KITLG -0.096 0.204 -9999.0 0.0 -0.446 123.0 123.0 cell motility -0.272 0.358 -9999.0 0.0 -0.741 167.0 167.0 PTPN6 0.023 0.037 -9999.0 0.0 -0.427 3.0 3.0 EPOR -0.091 0.162 -9999.0 0.0 -0.959 2.0 2.0 STAT5A (dimer) -0.225 0.3 -9999.0 0.0 -0.627 161.0 161.0 SOCS1 0.015 0.031 -9999.0 0.0 -0.321 4.0 4.0 cell migration 0.173 0.221 0.46 168.0 -9999.0 0.0 168.0 SOS1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 EPO -0.03 0.099 -9999.0 0.0 -0.264 80.0 80.0 VAV1 -0.014 0.116 -9999.0 0.0 -0.388 42.0 42.0 GRB10 -0.178 0.229 -9999.0 0.0 -0.478 164.0 164.0 PTPN11 0.022 0.024 -9999.0 0.0 -0.504 1.0 1.0 SCF/KIT -0.184 0.233 -9999.0 0.0 -0.493 163.0 163.0 GO:0007205 0.008 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.063 0.129 -9999.0 0.0 -0.282 58.0 58.0 CBL 0.017 0.012 -9999.0 0.0 -0.254 1.0 1.0 KIT -0.327 0.529 -9999.0 0.0 -1.327 108.0 108.0 MAP2K2 -0.064 0.131 -9999.0 0.0 -0.286 60.0 60.0 SHC/Grb2/SOS1 -0.144 0.215 -9999.0 0.0 -0.445 148.0 148.0 STAT5A -0.233 0.31 -9999.0 0.0 -0.648 161.0 161.0 GRB2 0.016 0.024 -9999.0 0.0 -0.254 4.0 4.0 response to radiation -0.19 0.242 -9999.0 0.0 -0.494 174.0 174.0 SHC/GRAP2 0.022 0.034 -9999.0 0.0 -0.369 2.0 2.0 PTPRO -0.177 0.232 -9999.0 0.0 -0.484 163.0 163.0 SH2B2 -0.175 0.222 -9999.0 0.0 -0.47 163.0 163.0 DOK1 0.002 0.083 -9999.0 0.0 -0.409 19.0 19.0 MATK -0.176 0.226 -9999.0 0.0 -0.47 168.0 168.0 CREBBP 0.003 0.059 -9999.0 0.0 -0.542 2.0 2.0 BCL2 -0.329 0.551 -9999.0 0.0 -1.334 117.0 117.0