Fc-epsilon receptor I signaling in mast cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PPAP2A 0.028 0.051 -9999.0 0.0 -0.429 6.0 6.0 LAT2 -0.051 0.142 -9999.0 0.0 -0.322 85.0 85.0 AP1 -0.075 0.207 0.319 1.0 -0.474 71.0 72.0 mol:PIP3 -0.032 0.192 0.285 17.0 -0.396 69.0 86.0 IKBKB 0.007 0.132 0.261 42.0 -0.246 42.0 84.0 AKT1 0.011 0.178 0.327 69.0 -0.374 27.0 96.0 IKBKG -0.012 0.117 0.213 17.0 -0.249 46.0 63.0 MS4A2 -0.078 0.191 -9999.0 0.0 -0.419 119.0 119.0 mol:Sphingosine-1-phosphate 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.031 0.023 -9999.0 0.0 -0.429 1.0 1.0 MAP3K1 -0.038 0.169 0.259 14.0 -0.383 63.0 77.0 mol:Ca2+ -0.018 0.154 0.256 18.0 -0.33 51.0 69.0 LYN 0.03 0.017 -9999.0 0.0 -9999.0 0.0 0.0 CBLB -0.051 0.141 -9999.0 0.0 -0.327 79.0 79.0 SHC1 0.027 0.025 -9999.0 0.0 -0.429 1.0 1.0 RasGAP/p62DOK 0.032 0.095 -9999.0 0.0 -0.253 46.0 46.0 positive regulation of cell migration -0.006 0.065 -9999.0 0.0 -0.303 23.0 23.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLD2 -0.01 0.179 0.307 69.0 -0.33 56.0 125.0 PTPN13 -0.072 0.195 -9999.0 0.0 -0.568 38.0 38.0 PTPN11 0.031 0.024 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of mast cell degranulation -0.007 0.145 0.309 17.0 -0.325 27.0 44.0 SYK 0.005 0.117 -9999.0 0.0 -0.435 33.0 33.0 GRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LAT/PLCgamma1/GRB2/SLP76/GADs -0.06 0.165 -9999.0 0.0 -0.384 79.0 79.0 LAT -0.048 0.136 -9999.0 0.0 -0.324 76.0 76.0 PAK2 -0.032 0.174 0.267 16.0 -0.414 53.0 69.0 NFATC2 -0.013 0.068 -9999.0 0.0 -0.595 4.0 4.0 HRAS -0.038 0.183 0.258 10.0 -0.453 53.0 63.0 GAB2 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLA2G1B 0.012 0.113 -9999.0 0.0 -0.925 6.0 6.0 Fc epsilon R1 -0.036 0.161 -9999.0 0.0 -0.316 112.0 112.0 Antigen/IgE/Fc epsilon R1 -0.031 0.146 -9999.0 0.0 -0.283 112.0 112.0 mol:GDP -0.06 0.179 0.26 1.0 -0.486 53.0 54.0 JUN -0.003 0.124 -9999.0 0.0 -0.429 39.0 39.0 mol:Ca++ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.431 17.0 17.0 FOS -0.033 0.155 -9999.0 0.0 -0.429 66.0 66.0 Antigen/IgE/Fc epsilon R1/LYN/SYK -0.049 0.146 -9999.0 0.0 -0.33 85.0 85.0 CHUK -0.014 0.12 0.211 18.0 -0.251 51.0 69.0 KLRG1 -0.04 0.126 -9999.0 0.0 -0.378 41.0 41.0 VAV1 -0.055 0.148 -9999.0 0.0 -0.342 82.0 82.0 calcium-dependent protein kinase C activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CBL -0.05 0.138 -9999.0 0.0 -0.317 84.0 84.0 negative regulation of mast cell degranulation -0.043 0.118 -9999.0 0.0 -0.36 40.0 40.0 BTK -0.059 0.185 -9999.0 0.0 -0.513 51.0 51.0 Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.068 0.185 -9999.0 0.0 -0.476 66.0 66.0 GAB2/PI3K/SHP2 -0.055 0.108 -9999.0 0.0 -0.323 47.0 47.0 Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.051 0.135 -9999.0 0.0 -0.281 104.0 104.0 RAF1 0.013 0.119 -9999.0 0.0 -0.995 6.0 6.0 Fc epsilon R1/FcgammaRIIB/SHIP -0.032 0.161 -9999.0 0.0 -0.292 121.0 121.0 FCER1G 0.032 0.019 -9999.0 0.0 -9999.0 0.0 0.0 FCER1A -0.027 0.152 -9999.0 0.0 -0.441 59.0 59.0 Antigen/IgE/Fc epsilon R1/Fyn -0.021 0.145 -9999.0 0.0 -0.275 107.0 107.0 MAPK3 0.012 0.117 -9999.0 0.0 -0.972 6.0 6.0 MAPK1 0.008 0.114 -9999.0 0.0 -0.91 6.0 6.0 NFKB1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 MAPK8 -0.038 0.219 -9999.0 0.0 -0.625 46.0 46.0 DUSP1 0.001 0.116 -9999.0 0.0 -0.429 34.0 34.0 NF-kappa-B/RelA 0.005 0.08 0.148 18.0 -0.164 34.0 52.0 actin cytoskeleton reorganization -0.046 0.178 -9999.0 0.0 -0.559 22.0 22.0 mol:Glucocorticoid Dexamethasone -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.032 0.177 0.267 2.0 -0.414 55.0 57.0 FER -0.05 0.139 -9999.0 0.0 -0.324 79.0 79.0 RELA 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITK -0.034 0.114 -9999.0 0.0 -0.395 40.0 40.0 SOS1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 PLCG1 -0.044 0.187 0.262 5.0 -0.475 52.0 57.0 cytokine secretion -0.005 0.051 -9999.0 0.0 -0.14 6.0 6.0 SPHK1 -0.057 0.146 -9999.0 0.0 -0.342 78.0 78.0 PTK2 -0.048 0.185 -9999.0 0.0 -0.598 21.0 21.0 NTAL/PLCgamma1/GRB2/SLP76/GADs -0.062 0.176 -9999.0 0.0 -0.398 82.0 82.0 EDG1 -0.006 0.065 -9999.0 0.0 -0.303 23.0 23.0 mol:DAG -0.035 0.192 0.288 14.0 -0.458 49.0 63.0 MAP2K2 0.008 0.113 -9999.0 0.0 -0.932 6.0 6.0 MAP2K1 0.008 0.112 -9999.0 0.0 -0.932 6.0 6.0 MAP2K7 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 KLRG1/SHP2 -0.027 0.12 -9999.0 0.0 -0.346 40.0 40.0 MAP2K4 -0.084 0.337 -9999.0 0.0 -0.929 67.0 67.0 Fc epsilon R1/FcgammaRIIB -0.034 0.172 -9999.0 0.0 -0.312 121.0 121.0 mol:Choline -0.01 0.177 0.305 69.0 -0.325 56.0 125.0 SHC/Grb2/SOS1 -0.013 0.149 -9999.0 0.0 -0.41 32.0 32.0 FYN 0.026 0.055 -9999.0 0.0 -0.429 7.0 7.0 DOK1 0.026 0.062 -9999.0 0.0 -0.429 9.0 9.0 PXN -0.046 0.172 -9999.0 0.0 -0.558 19.0 19.0 HCLS1 -0.053 0.144 -9999.0 0.0 -0.332 84.0 84.0 PRKCB -0.021 0.151 0.246 17.0 -0.331 51.0 68.0 FCGR2B -0.0 0.109 -9999.0 0.0 -0.429 30.0 30.0 IGHE 0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 KLRG1/SHIP -0.044 0.12 -9999.0 0.0 -0.367 40.0 40.0 LCP2 0.023 0.068 -9999.0 0.0 -0.43 11.0 11.0 PLA2G4A -0.054 0.15 -9999.0 0.0 -0.346 80.0 80.0 RASA1 0.026 0.058 -9999.0 0.0 -0.429 8.0 8.0 mol:Phosphatidic acid -0.01 0.177 0.305 69.0 -0.325 56.0 125.0 IKK complex 0.007 0.113 0.238 40.0 -0.201 33.0 73.0 WIPF1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0