E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.17 -9999.0 0.0 -0.422 71.0 71.0 KLHL20 -0.018 0.103 0.222 8.0 -0.259 24.0 32.0 CYFIP2 -0.008 0.132 -9999.0 0.0 -0.429 45.0 45.0 Rac1/GDP -0.029 0.124 0.264 7.0 -0.269 63.0 70.0 ENAH -0.065 0.166 -9999.0 0.0 -0.416 67.0 67.0 AP1M1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 RAP1B 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 RAP1A 0.03 0.046 -9999.0 0.0 -0.429 5.0 5.0 CTNNB1 0.022 0.071 -9999.0 0.0 -0.429 12.0 12.0 CDC42/GTP -0.011 0.087 -9999.0 0.0 -0.257 8.0 8.0 ABI1/Sra1/Nap1 -0.046 0.057 -9999.0 0.0 -0.169 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.029 0.108 -9999.0 0.0 -0.238 63.0 63.0 RAPGEF1 -0.065 0.16 -9999.0 0.0 -0.372 78.0 78.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.071 0.186 -9999.0 0.0 -0.422 85.0 85.0 CRK -0.064 0.167 -9999.0 0.0 -0.398 80.0 80.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.101 -9999.0 0.0 -0.265 49.0 49.0 alphaE/beta7 Integrin 0.045 0.035 -9999.0 0.0 -0.307 4.0 4.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.057 -9999.0 0.0 -0.233 15.0 15.0 DLG1 -0.075 0.176 -9999.0 0.0 -0.416 81.0 81.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.057 -9999.0 0.0 -0.182 15.0 15.0 MLLT4 0.024 0.059 -9999.0 0.0 -0.429 8.0 8.0 ARF6/GTP/NME1/Tiam1 0.052 0.048 -9999.0 0.0 -0.24 10.0 10.0 PI3K -0.034 0.074 -9999.0 0.0 -0.236 14.0 14.0 ARF6 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.006 0.107 -9999.0 0.0 -0.312 49.0 49.0 TIAM1 0.027 0.058 -9999.0 0.0 -0.429 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.028 0.099 -9999.0 0.0 -0.223 60.0 60.0 AKT1 -0.02 0.055 0.156 5.0 -0.171 5.0 10.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 CDH1 -0.014 0.134 -9999.0 0.0 -0.429 47.0 47.0 RhoA/GDP -0.031 0.127 0.27 6.0 -0.275 65.0 71.0 actin cytoskeleton organization -0.011 0.08 0.169 16.0 -0.188 23.0 39.0 CDC42/GDP -0.028 0.124 0.27 6.0 -0.268 63.0 69.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.007 0.078 -9999.0 0.0 -0.223 52.0 52.0 ITGB7 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.106 -9999.0 0.0 -0.238 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.09 -9999.0 0.0 -0.22 59.0 59.0 mol:GDP -0.048 0.13 0.271 6.0 -0.306 64.0 70.0 CDC42/GTP/IQGAP1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 p120 catenin/RhoA/GDP -0.025 0.133 0.277 6.0 -0.282 64.0 70.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.034 -9999.0 0.0 -0.307 4.0 4.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 CDC42 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.029 0.081 0.137 3.0 -0.19 80.0 83.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.077 0.178 -9999.0 0.0 -0.414 85.0 85.0 regulation of cell-cell adhesion -0.018 0.071 -9999.0 0.0 -0.207 13.0 13.0 WASF2 -0.012 0.046 0.104 8.0 -0.111 14.0 22.0 Rap1/GTP -0.013 0.096 0.245 1.0 -0.28 9.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.106 -9999.0 0.0 -0.231 53.0 53.0 CCND1 -0.036 0.099 0.157 3.0 -0.236 80.0 83.0 VAV2 -0.062 0.196 -9999.0 0.0 -0.603 17.0 17.0 RAP1/GDP -0.016 0.108 0.259 2.0 -0.29 13.0 15.0 adherens junction assembly -0.073 0.173 -9999.0 0.0 -0.401 85.0 85.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.023 0.103 -9999.0 0.0 -0.222 65.0 65.0 E-cadherin/beta catenin -0.026 0.104 -9999.0 0.0 -0.293 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.077 0.177 -9999.0 0.0 -0.413 85.0 85.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 Rac1/GTP -0.078 0.135 -9999.0 0.0 -0.415 32.0 32.0 E-cadherin/beta catenin/alpha catenin 0.017 0.106 -9999.0 0.0 -0.26 59.0 59.0 ITGAE 0.028 0.042 -9999.0 0.0 -0.429 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.073 0.19 -9999.0 0.0 -0.431 85.0 85.0