IL4-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.344 0.631 -9999.0 0.0 -1.336 114.0 114.0 STAT6 (cleaved dimer) -0.362 0.639 -9999.0 0.0 -1.3 133.0 133.0 IGHG1 -0.079 0.243 -9999.0 0.0 -0.682 16.0 16.0 IGHG3 -0.339 0.604 -9999.0 0.0 -1.219 133.0 133.0 AKT1 -0.115 0.323 -9999.0 0.0 -0.882 32.0 32.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.065 0.265 -9999.0 0.0 -0.944 18.0 18.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.139 0.356 -9999.0 0.0 -0.88 48.0 48.0 THY1 -0.362 0.654 -9999.0 0.0 -1.37 119.0 119.0 MYB -0.06 0.184 -9999.0 0.0 -0.429 100.0 100.0 HMGA1 0.033 0.03 -9999.0 0.0 -0.429 2.0 2.0 IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.134 0.345 -9999.0 0.0 -0.732 58.0 58.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.118 0.327 -9999.0 0.0 -0.969 27.0 27.0 SP1 0.024 0.047 -9999.0 0.0 -0.139 7.0 7.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOCS5 0.019 0.056 -9999.0 0.0 -0.431 4.0 4.0 STAT6 (dimer)/ETS1 -0.352 0.634 -9999.0 0.0 -1.285 131.0 131.0 SOCS1 -0.189 0.385 -9999.0 0.0 -0.777 103.0 103.0 SOCS3 -0.113 0.322 -9999.0 0.0 -0.978 23.0 23.0 FCER2 -0.228 0.466 -9999.0 0.0 -0.952 94.0 94.0 PARP14 0.028 0.055 -9999.0 0.0 -0.429 7.0 7.0 CCL17 -0.412 0.703 -9999.0 0.0 -1.376 150.0 150.0 GRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.074 0.264 -9999.0 0.0 -0.746 25.0 25.0 T cell proliferation -0.358 0.658 -9999.0 0.0 -1.353 125.0 125.0 IL4R/JAK1 -0.354 0.644 -9999.0 0.0 -1.313 128.0 128.0 EGR2 -0.394 0.689 -9999.0 0.0 -1.396 134.0 134.0 JAK2 -0.004 0.068 -9999.0 0.0 -0.464 2.0 2.0 JAK3 0.038 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 JAK1 0.018 0.048 -9999.0 0.0 -0.423 3.0 3.0 COL1A2 -0.215 0.536 -9999.0 0.0 -1.474 70.0 70.0 CCL26 -0.351 0.636 -9999.0 0.0 -1.287 130.0 130.0 IL4R -0.378 0.701 -9999.0 0.0 -1.455 120.0 120.0 PTPN6 0.021 0.045 -9999.0 0.0 -0.416 2.0 2.0 IL13RA2 -0.392 0.668 -9999.0 0.0 -1.347 137.0 137.0 IL13RA1 -0.009 0.086 -9999.0 0.0 -0.464 8.0 8.0 IRF4 -0.018 0.189 -9999.0 0.0 -0.877 12.0 12.0 ARG1 -0.058 0.264 -9999.0 0.0 -1.084 16.0 16.0 CBL -0.131 0.322 -9999.0 0.0 -0.69 59.0 59.0 GTF3A 0.023 0.045 -9999.0 0.0 -0.143 7.0 7.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 IL13RA1/JAK2 0.0 0.1 -9999.0 0.0 -0.377 7.0 7.0 IRF4/BCL6 -0.017 0.186 -9999.0 0.0 -0.826 12.0 12.0 CD40LG 0.037 0.038 -9999.0 0.0 -0.428 3.0 3.0 MAPK14 -0.131 0.329 -9999.0 0.0 -0.872 30.0 30.0 mitosis -0.107 0.307 -9999.0 0.0 -0.816 32.0 32.0 STAT6 -0.45 0.863 -9999.0 0.0 -1.663 132.0 132.0 SPI1 0.033 0.048 -9999.0 0.0 -0.298 8.0 8.0 RPS6KB1 -0.086 0.301 -9999.0 0.0 -0.801 29.0 29.0 STAT6 (dimer) -0.45 0.865 -9999.0 0.0 -1.663 132.0 132.0 STAT6 (dimer)/PARP14 -0.398 0.716 -9999.0 0.0 -1.432 133.0 133.0 mast cell activation 0.004 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.137 0.344 -9999.0 0.0 -0.908 40.0 40.0 FRAP1 -0.115 0.323 -9999.0 0.0 -0.883 32.0 32.0 LTA -0.35 0.632 -9999.0 0.0 -1.324 118.0 118.0 FES 0.029 0.047 -9999.0 0.0 -0.429 5.0 5.0 T-helper 1 cell differentiation 0.408 0.763 1.508 132.0 -9999.0 0.0 132.0 CCL11 -0.382 0.65 -9999.0 0.0 -1.32 136.0 136.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.101 0.315 -9999.0 0.0 -0.947 25.0 25.0 IL2RG 0.032 0.043 -9999.0 0.0 -0.417 4.0 4.0 IL10 -0.317 0.645 -9999.0 0.0 -1.318 116.0 116.0 IRS1 -0.017 0.145 -9999.0 0.0 -0.429 55.0 55.0 IRS2 0.008 0.099 -9999.0 0.0 -0.429 24.0 24.0 IL4 -0.06 0.286 -9999.0 0.0 -1.307 18.0 18.0 IL5 -0.35 0.632 -9999.0 0.0 -1.326 118.0 118.0 IL4/IL4R/JAK1/IL13RA1/JAK2 -0.245 0.506 -9999.0 0.0 -0.967 120.0 120.0 COL1A1 -0.247 0.583 -9999.0 0.0 -1.459 83.0 83.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1 -0.375 0.679 -9999.0 0.0 -1.473 109.0 109.0 IL2R gamma/JAK3 0.051 0.036 -9999.0 0.0 -0.296 4.0 4.0 TFF3 -0.52 0.759 -9999.0 0.0 -1.381 197.0 197.0 ALOX15 -0.357 0.643 -9999.0 0.0 -1.304 130.0 130.0 MYBL1 -0.012 0.127 -9999.0 0.0 -0.429 42.0 42.0 T-helper 2 cell differentiation -0.264 0.514 -9999.0 0.0 -1.025 117.0 117.0 SHC1 0.027 0.025 -9999.0 0.0 -0.429 1.0 1.0 CEBPB 0.027 0.057 -9999.0 0.0 -0.307 11.0 11.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.122 0.33 -9999.0 0.0 -0.866 37.0 37.0 mol:PI-3-4-5-P3 -0.115 0.323 -9999.0 0.0 -0.882 32.0 32.0 PI3K -0.125 0.345 -9999.0 0.0 -0.971 32.0 32.0 DOK2 0.008 0.09 -9999.0 0.0 -0.429 20.0 20.0 ETS1 0.012 0.047 -9999.0 0.0 -0.392 2.0 2.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.061 0.247 -9999.0 0.0 -0.706 21.0 21.0 ITGB3 -0.349 0.638 -9999.0 0.0 -1.335 118.0 118.0 PIGR -0.446 0.765 -9999.0 0.0 -1.429 168.0 168.0 IGHE 0.014 0.088 0.18 58.0 -0.223 8.0 66.0 MAPKKK cascade -0.059 0.243 -9999.0 0.0 -0.689 21.0 21.0 BCL6 0.017 0.086 -9999.0 0.0 -0.43 18.0 18.0 OPRM1 -0.348 0.634 -9999.0 0.0 -1.327 118.0 118.0 RETNLB -0.348 0.633 -9999.0 0.0 -1.328 117.0 117.0 SELP -0.419 0.74 -9999.0 0.0 -1.437 149.0 149.0 AICDA -0.344 0.609 -9999.0 0.0 -1.306 113.0 113.0