Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.036 0.054 0.319 8.0 -9999.0 0.0 8.0 KIRREL 0.025 0.059 -9999.0 0.0 -0.441 7.0 7.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.037 0.054 -9999.0 0.0 -0.319 8.0 8.0 PLCG1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.028 0.055 -9999.0 0.0 -0.429 7.0 7.0 Nephrin/NEPH1/podocin/CD2AP 0.065 0.059 -9999.0 0.0 -0.239 9.0 9.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.048 -9999.0 0.0 -0.214 16.0 16.0 FYN 0.051 0.099 0.28 58.0 -0.213 15.0 73.0 mol:Ca2+ 0.059 0.058 -9999.0 0.0 -0.237 9.0 9.0 mol:DAG 0.06 0.059 -9999.0 0.0 -0.238 9.0 9.0 NPHS2 0.03 0.03 -9999.0 0.0 -0.437 1.0 1.0 mol:IP3 0.06 0.059 -9999.0 0.0 -0.238 9.0 9.0 regulation of endocytosis 0.045 0.057 -9999.0 0.0 -0.205 14.0 14.0 Nephrin/NEPH1/podocin/Cholesterol 0.047 0.052 -9999.0 0.0 -0.235 9.0 9.0 establishment of cell polarity 0.036 0.054 -9999.0 0.0 -0.319 8.0 8.0 Nephrin/NEPH1/podocin/NCK1-2 0.076 0.065 -9999.0 0.0 -0.222 10.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.047 0.058 -9999.0 0.0 -0.207 14.0 14.0 NPHS1 0.038 0.031 -9999.0 0.0 -0.437 1.0 1.0 Nephrin/NEPH1/podocin 0.047 0.059 -9999.0 0.0 -0.213 15.0 15.0 TJP1 0.03 0.042 -9999.0 0.0 -0.429 4.0 4.0 NCK1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 NCK2 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.062 0.06 -9999.0 0.0 -0.239 9.0 9.0 CD2AP 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.061 0.059 -9999.0 0.0 -0.239 9.0 9.0 GRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.051 0.103 0.289 58.0 -0.223 15.0 73.0 cytoskeleton organization 0.019 0.065 0.233 23.0 -0.258 9.0 32.0 Nephrin/NEPH1 0.032 0.04 -9999.0 0.0 -0.219 8.0 8.0 Nephrin/NEPH1/ZO-1 0.048 0.059 -9999.0 0.0 -0.262 12.0 12.0