Class I PI3K signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ARF5/GTP -0.017 0.063 0.2 13.0 -0.208 22.0 35.0 DAPP1 -0.038 0.164 0.243 2.0 -0.398 61.0 63.0 Src family/SYK family/BLNK-LAT/BTK-ITK -0.059 0.229 -9999.0 0.0 -0.564 65.0 65.0 mol:DAG -0.014 0.096 0.216 10.0 -0.23 46.0 56.0 HRAS 0.03 0.039 -9999.0 0.0 -0.433 3.0 3.0 RAP1A 0.029 0.048 -9999.0 0.0 -0.431 5.0 5.0 ARF5/GDP -0.005 0.112 -9999.0 0.0 -0.312 33.0 33.0 PLCG2 0.019 0.059 -9999.0 0.0 -0.429 8.0 8.0 PLCG1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF5 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 mol:GTP -0.017 0.062 0.191 14.0 -0.215 21.0 35.0 ARF1/GTP -0.008 0.055 0.203 9.0 -0.199 18.0 27.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 YES1 0.028 0.051 -9999.0 0.0 -0.429 6.0 6.0 RAP1A/GTP -0.015 0.065 0.18 32.0 -0.214 21.0 53.0 ADAP1 -0.017 0.059 0.186 13.0 -0.205 21.0 34.0 ARAP3 -0.017 0.062 0.19 14.0 -0.212 21.0 35.0 INPPL1 0.03 0.037 -9999.0 0.0 -0.429 3.0 3.0 PREX1 -0.037 0.162 -9999.0 0.0 -0.429 73.0 73.0 ARHGEF6 0.015 0.093 -9999.0 0.0 -0.429 21.0 21.0 ARHGEF7 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF1 0.028 0.025 -9999.0 0.0 -0.429 1.0 1.0 NRAS 0.027 0.056 -9999.0 0.0 -0.429 7.0 7.0 FYN 0.026 0.055 -9999.0 0.0 -0.429 7.0 7.0 ARF6 0.033 0.03 -9999.0 0.0 -0.429 2.0 2.0 FGR 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.007 0.053 0.159 13.0 -0.129 22.0 35.0 mol:IP4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.027 0.058 -9999.0 0.0 -0.429 8.0 8.0 ZAP70 0.032 0.022 -9999.0 0.0 -0.429 1.0 1.0 mol:IP3 -0.013 0.071 0.192 12.0 -0.176 31.0 43.0 LYN 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARF1/GDP -0.003 0.103 -9999.0 0.0 -0.315 27.0 27.0 RhoA/GDP 0.011 0.094 0.229 7.0 -0.304 15.0 22.0 PDK1/Src/Hsp90 0.04 0.025 -9999.0 0.0 -0.258 2.0 2.0 BLNK 0.012 0.101 -9999.0 0.0 -0.429 25.0 25.0 actin cytoskeleton reorganization -0.021 0.11 0.231 4.0 -0.356 24.0 28.0 SRC 0.031 0.03 -9999.0 0.0 -0.429 2.0 2.0 PLEKHA2 -0.008 0.023 -9999.0 0.0 -0.257 4.0 4.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTEN 0.024 0.066 -9999.0 0.0 -0.404 11.0 11.0 HSP90AA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.017 0.062 0.2 13.0 -0.208 21.0 34.0 RhoA/GTP -0.02 0.072 0.202 13.0 -0.24 25.0 38.0 Src family/SYK family/BLNK-LAT -0.028 0.165 -9999.0 0.0 -0.432 54.0 54.0 BLK 0.02 0.044 -9999.0 0.0 -0.429 4.0 4.0 PDPK1 0.031 0.023 -9999.0 0.0 -0.429 1.0 1.0 CYTH1 -0.017 0.059 0.186 13.0 -0.205 21.0 34.0 HCK 0.017 0.086 -9999.0 0.0 -0.429 18.0 18.0 CYTH3 -0.017 0.059 0.186 13.0 -0.205 21.0 34.0 CYTH2 -0.017 0.059 0.186 13.0 -0.205 21.0 34.0 KRAS 0.026 0.056 -9999.0 0.0 -0.433 7.0 7.0 GO:0030676 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 0.006 0.041 0.231 2.0 -0.2 2.0 4.0 SGK1 0.008 0.043 0.21 3.0 -0.212 2.0 5.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.021 0.108 -9999.0 0.0 -0.318 34.0 34.0 SOS1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 SYK 0.004 0.115 -9999.0 0.0 -0.429 33.0 33.0 ARF6/GDP -0.002 0.078 0.202 7.0 -0.256 14.0 21.0 mol:PI-3-4-5-P3 -0.017 0.064 0.222 13.0 -0.215 21.0 34.0 ARAP3/RAP1A/GTP -0.015 0.066 0.181 32.0 -0.215 21.0 53.0 VAV1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 mol:PI-3-4-P2 0.006 0.024 -9999.0 0.0 -0.303 3.0 3.0 RAS family/GTP/PI3K Class I 0.043 0.066 0.213 19.0 -0.218 21.0 40.0 PLEKHA1 -0.011 0.027 -9999.0 0.0 -0.258 6.0 6.0 Rac1/GDP -0.004 0.111 -9999.0 0.0 -0.312 32.0 32.0 LAT 0.029 0.031 -9999.0 0.0 -0.429 2.0 2.0 Rac1/GTP -0.019 0.117 -9999.0 0.0 -0.354 36.0 36.0 ITK -0.031 0.077 0.189 13.0 -0.222 49.0 62.0 Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.026 0.127 0.246 8.0 -0.315 52.0 60.0 LCK -0.019 0.143 -9999.0 0.0 -0.429 54.0 54.0 BTK -0.024 0.071 0.187 13.0 -0.229 32.0 45.0