Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.198 -9999.0 0.0 -0.577 56.0 56.0 IHH 0.015 0.089 -9999.0 0.0 -0.281 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.028 0.108 -9999.0 0.0 -0.242 99.0 99.0 LRPAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.028 0.108 0.241 99.0 -9999.0 0.0 99.0 SMO/beta Arrestin2 -0.019 0.17 -9999.0 0.0 -0.364 78.0 78.0 SMO -0.04 0.162 -9999.0 0.0 -0.364 87.0 87.0 AKT1 -0.011 0.151 -9999.0 0.0 -0.59 23.0 23.0 ARRB2 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.097 -9999.0 0.0 -0.429 23.0 23.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.161 -9999.0 0.0 -0.359 87.0 87.0 STIL -0.008 0.134 0.2 68.0 -0.229 104.0 172.0 DHH N/PTCH2 0.051 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.001 0.118 -9999.0 0.0 -0.29 69.0 69.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 DHH 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.067 0.255 -9999.0 0.0 -0.681 65.0 65.0 determination of left/right symmetry -0.037 0.161 -9999.0 0.0 -0.359 87.0 87.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 skeletal system development -0.066 0.251 -9999.0 0.0 -0.673 65.0 65.0 IHH N/Hhip 0.032 0.065 -9999.0 0.0 -0.292 12.0 12.0 DHH N/Hhip 0.048 0.03 -9999.0 0.0 -0.307 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.161 -9999.0 0.0 -0.359 87.0 87.0 pancreas development 0.031 0.036 -9999.0 0.0 -0.428 3.0 3.0 HHAT -0.018 0.137 -9999.0 0.0 -0.429 50.0 50.0 PI3K 0.033 0.066 -9999.0 0.0 -0.307 17.0 17.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.031 0.16 -9999.0 0.0 -0.429 70.0 70.0 somite specification -0.037 0.161 -9999.0 0.0 -0.359 87.0 87.0 SHH Np/Cholesterol/PTCH1 -0.031 0.11 -9999.0 0.0 -0.236 102.0 102.0 SHH Np/Cholesterol/PTCH2 0.002 0.076 -9999.0 0.0 -0.235 45.0 45.0 SHH Np/Cholesterol/Megalin -0.06 0.143 -9999.0 0.0 -0.28 137.0 137.0 SHH -0.017 0.093 -9999.0 0.0 -0.307 46.0 46.0 catabolic process -0.028 0.122 -9999.0 0.0 -0.324 69.0 69.0 SMO/Vitamin D3 -0.028 0.146 0.201 24.0 -0.331 64.0 88.0 SHH Np/Cholesterol/Hhip 0.001 0.077 -9999.0 0.0 -0.235 46.0 46.0 LRP2 -0.103 0.21 -9999.0 0.0 -0.429 147.0 147.0 receptor-mediated endocytosis -0.076 0.176 -9999.0 0.0 -0.362 99.0 99.0 SHH Np/Cholesterol/BOC -0.009 0.088 -9999.0 0.0 -0.234 64.0 64.0 SHH Np/Cholesterol/CDO -0.008 0.086 -9999.0 0.0 -0.243 56.0 56.0 mesenchymal cell differentiation -0.001 0.077 0.234 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.01 0.131 0.2 55.0 -0.238 100.0 155.0 IHH N/PTCH2 0.035 0.06 -9999.0 0.0 -0.277 10.0 10.0 CDON 0.018 0.074 -9999.0 0.0 -0.429 13.0 13.0 IHH N/PTCH1 -0.008 0.13 -9999.0 0.0 -0.326 69.0 69.0 Megalin/LRPAP1 -0.056 0.162 -9999.0 0.0 -0.306 147.0 147.0 PTCH2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.007 0.072 -9999.0 0.0 -0.233 46.0 46.0 PTCH1 -0.028 0.122 -9999.0 0.0 -0.325 69.0 69.0 HHIP 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0