Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.085 -9999.0 0.0 -0.218 68.0 68.0 epithelial cell differentiation 0.024 0.096 -9999.0 0.0 -0.221 60.0 60.0 CYFIP2 -0.008 0.132 -9999.0 0.0 -0.429 45.0 45.0 ENAH -0.023 0.084 0.263 5.0 -0.313 8.0 13.0 EGFR -0.016 0.135 -9999.0 0.0 -0.429 48.0 48.0 EPHA2 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 MYO6 -0.036 0.083 0.199 11.0 -0.221 69.0 80.0 CTNNB1 0.022 0.071 -9999.0 0.0 -0.429 12.0 12.0 ABI1/Sra1/Nap1 0.038 0.092 -9999.0 0.0 -0.261 41.0 41.0 AQP5 -0.094 0.175 0.332 1.0 -0.455 83.0 84.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 mol:PI-4-5-P2 -0.032 0.076 0.198 10.0 -0.216 58.0 68.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.075 0.27 2.0 -0.213 49.0 51.0 EGF -0.07 0.188 -9999.0 0.0 -0.429 108.0 108.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 AQP3 -0.092 0.174 -9999.0 0.0 -0.452 83.0 83.0 cortical microtubule organization 0.024 0.096 -9999.0 0.0 -0.221 60.0 60.0 GO:0000145 -0.032 0.071 0.183 10.0 -0.206 58.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.1 -9999.0 0.0 -0.223 60.0 60.0 MLLT4 0.024 0.059 -9999.0 0.0 -0.429 8.0 8.0 ARF6/GDP -0.042 0.071 -9999.0 0.0 -0.374 7.0 7.0 ARF6 0.033 0.03 -9999.0 0.0 -0.429 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.052 0.07 -9999.0 0.0 -0.239 18.0 18.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.101 0.24 3.0 -0.366 17.0 20.0 PVRL2 0.025 0.065 -9999.0 0.0 -0.429 10.0 10.0 ZYX -0.034 0.081 0.199 11.0 -0.221 66.0 77.0 ARF6/GTP 0.057 0.076 -9999.0 0.0 -0.248 18.0 18.0 CDH1 -0.014 0.134 -9999.0 0.0 -0.429 47.0 47.0 EGFR/EGFR/EGF/EGF -0.058 0.138 -9999.0 0.0 -0.227 188.0 188.0 RhoA/GDP 0.021 0.101 -9999.0 0.0 -0.218 67.0 67.0 actin cytoskeleton organization -0.039 0.079 0.189 8.0 -0.216 72.0 80.0 IGF-1R heterotetramer -0.046 0.173 -9999.0 0.0 -0.428 85.0 85.0 GIT1 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 IGF1R -0.046 0.173 -9999.0 0.0 -0.429 85.0 85.0 IGF1 -0.041 0.167 -9999.0 0.0 -0.429 78.0 78.0 DIAPH1 -0.002 0.204 -9999.0 0.0 -0.587 37.0 37.0 Wnt receptor signaling pathway -0.024 0.096 0.221 60.0 -9999.0 0.0 60.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 RhoA/GTP -0.044 0.072 -9999.0 0.0 -0.353 8.0 8.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.04 0.081 0.197 6.0 -0.221 72.0 78.0 EFNA1 0.013 0.082 -9999.0 0.0 -0.429 16.0 16.0 LPP -0.038 0.078 0.189 11.0 -0.388 2.0 13.0 Ephrin A1/EPHA2 0.008 0.096 -9999.0 0.0 -0.227 61.0 61.0 SEC6/SEC8 -0.047 0.07 -9999.0 0.0 -0.216 61.0 61.0 MGAT3 -0.032 0.076 0.36 1.0 -0.216 49.0 50.0 HGF/MET 0.014 0.096 -9999.0 0.0 -0.211 68.0 68.0 HGF 0.027 0.058 -9999.0 0.0 -0.429 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.014 0.086 -9999.0 0.0 -0.22 68.0 68.0 actin cable formation 0.016 0.113 0.226 50.0 -0.318 8.0 58.0 KIAA1543 -0.036 0.075 0.191 9.0 -0.22 55.0 64.0 KIFC3 -0.032 0.074 0.202 9.0 -0.216 53.0 62.0 NCK1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 EXOC3 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.08 0.199 11.0 -0.219 61.0 72.0 NCK1/GIT1 0.046 0.022 -9999.0 0.0 -0.307 1.0 1.0 mol:GDP 0.024 0.096 -9999.0 0.0 -0.221 60.0 60.0 EXOC4 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.035 0.066 -9999.0 0.0 -0.211 60.0 60.0 PIP5K1C -0.032 0.077 0.2 10.0 -0.219 58.0 68.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.109 0.295 10.0 -0.331 7.0 17.0 adherens junction assembly -0.049 0.134 0.307 3.0 -0.507 20.0 23.0 IGF-1R heterotetramer/IGF1 -0.059 0.152 -9999.0 0.0 -0.251 175.0 175.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.066 -9999.0 0.0 -0.305 17.0 17.0 MET 0.03 0.037 -9999.0 0.0 -0.429 3.0 3.0 PLEKHA7 -0.032 0.076 0.272 2.0 -0.216 54.0 56.0 mol:GTP 0.05 0.068 -9999.0 0.0 -0.238 18.0 18.0 establishment of epithelial cell apical/basal polarity -0.038 0.079 0.151 4.0 -0.335 4.0 8.0 cortical actin cytoskeleton stabilization -0.014 0.085 -9999.0 0.0 -0.218 68.0 68.0 regulation of cell-cell adhesion -0.039 0.079 0.189 8.0 -0.216 72.0 80.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.014 0.086 -9999.0 0.0 -0.22 68.0 68.0