IL2 signaling events mediated by PI3K Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.011 0.121 -9999.0 0.0 -0.546 5.0 5.0 UGCG -0.091 0.266 -9999.0 0.0 -0.73 71.0 71.0 AKT1/mTOR/p70S6K/Hsp90/TERT -0.064 0.187 -9999.0 0.0 -0.37 101.0 101.0 mol:GTP -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:glucosylceramide -0.09 0.263 -9999.0 0.0 -0.717 72.0 72.0 mol:DAG -0.006 0.028 0.168 12.0 -9999.0 0.0 12.0 CaM/Ca2+/Calcineurin A alpha-beta B1 -0.082 0.232 -9999.0 0.0 -0.444 111.0 111.0 FRAP1 -0.105 0.264 -9999.0 0.0 -0.516 111.0 111.0 FOXO3 -0.052 0.203 -9999.0 0.0 -0.515 48.0 48.0 AKT1 -0.058 0.222 -9999.0 0.0 -0.563 48.0 48.0 GAB2 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SMPD1 -0.005 0.13 -9999.0 0.0 -0.71 15.0 15.0 SGMS1 -0.005 0.035 -9999.0 0.0 -0.079 46.0 46.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.008 0.049 -9999.0 0.0 -0.258 17.0 17.0 CALM1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.044 0.182 0.234 5.0 -0.364 96.0 101.0 EIF3A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.067 -9999.0 0.0 -0.307 17.0 17.0 RPS6KB1 -0.033 0.12 -9999.0 0.0 -0.674 6.0 6.0 mol:sphingomyelin -0.006 0.028 0.168 12.0 -9999.0 0.0 12.0 natural killer cell activation -0.002 0.004 -9999.0 0.0 -0.013 28.0 28.0 JAK3 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.016 0.084 -9999.0 0.0 -0.429 17.0 17.0 JAK1 0.031 0.037 -9999.0 0.0 -0.431 3.0 3.0 NFKB1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 MYC -0.031 0.286 0.413 1.0 -0.934 35.0 36.0 MYB -0.227 0.498 -9999.0 0.0 -1.186 105.0 105.0 IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.024 0.152 -9999.0 0.0 -0.388 41.0 41.0 40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.018 0.118 -9999.0 0.0 -0.545 8.0 8.0 mol:PI-3-4-5-P3 -0.023 0.15 -9999.0 0.0 -0.379 41.0 41.0 Rac1/GDP 0.008 0.052 -9999.0 0.0 -0.236 17.0 17.0 T cell proliferation -0.021 0.141 0.249 2.0 -0.361 39.0 41.0 SHC1 0.025 0.026 -9999.0 0.0 -0.429 1.0 1.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of cyclin-dependent protein kinase activity -0.01 0.028 -9999.0 0.0 -0.066 103.0 103.0 PRKCZ -0.023 0.145 0.254 1.0 -0.374 39.0 40.0 NF kappa B1 p50/RelA -0.073 0.241 -9999.0 0.0 -0.464 99.0 99.0 IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.014 0.13 -9999.0 0.0 -0.424 33.0 33.0 HSP90AA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL2RA 0.001 0.111 -9999.0 0.0 -0.429 31.0 31.0 IL2RB 0.01 0.097 -9999.0 0.0 -0.429 23.0 23.0 TERT 0.031 0.03 -9999.0 0.0 -0.429 2.0 2.0 E2F1 -0.072 0.197 -9999.0 0.0 -0.429 112.0 112.0 SOS1 0.031 0.023 -9999.0 0.0 -0.435 1.0 1.0 RPS6 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 mol:cAMP 0.005 0.014 0.031 103.0 -9999.0 0.0 103.0 PTPN11 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IL2RG 0.028 0.043 -9999.0 0.0 -0.428 4.0 4.0 actin cytoskeleton organization -0.021 0.141 0.249 2.0 -0.361 39.0 41.0 GRB2 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.029 0.038 -9999.0 0.0 -0.43 3.0 3.0 PIK3CA 0.03 0.025 -9999.0 0.0 -0.434 1.0 1.0 Rac1/GTP 0.032 0.064 -9999.0 0.0 -0.222 17.0 17.0 LCK -0.021 0.143 -9999.0 0.0 -0.429 54.0 54.0 BCL2 -0.177 0.378 0.4 1.0 -0.819 119.0 120.0