Signaling events regulated by Ret tyrosine kinase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 -0.041 0.139 -9999.0 0.0 -0.535 30.0 30.0 Crk/p130 Cas/Paxillin -0.132 0.163 -9999.0 0.0 -0.337 165.0 165.0 JUN -0.136 0.185 0.194 2.0 -0.422 112.0 114.0 HRAS 0.031 0.037 -9999.0 0.0 -0.429 3.0 3.0 RET51/GFRalpha1/GDNF/GRB10 -0.111 0.203 -9999.0 0.0 -0.318 227.0 227.0 RAP1A 0.03 0.046 -9999.0 0.0 -0.429 5.0 5.0 FRS2 0.032 0.022 -9999.0 0.0 -0.429 1.0 1.0 RAP1A/GDP 0.022 0.033 -9999.0 0.0 -0.303 5.0 5.0 RET51/GFRalpha1/GDNF/DOK1 -0.109 0.208 -9999.0 0.0 -0.327 220.0 220.0 EntrezGene:5979 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.031 0.023 -9999.0 0.0 -0.429 1.0 1.0 RET9/GFRalpha1/GDNF/Enigma -0.049 0.14 -9999.0 0.0 -0.238 175.0 175.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 RAP1A/GTP -0.101 0.184 -9999.0 0.0 -0.292 221.0 221.0 GRB7 0.022 0.059 -9999.0 0.0 -0.429 8.0 8.0 RET51/GFRalpha1/GDNF -0.104 0.203 -9999.0 0.0 -0.319 219.0 219.0 MAPKKK cascade -0.119 0.193 -9999.0 0.0 -0.329 205.0 205.0 BCAR1 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/IRS1 -0.072 0.175 -9999.0 0.0 -0.289 184.0 184.0 lamellipodium assembly -0.108 0.164 -9999.0 0.0 -0.314 165.0 165.0 RET51/GFRalpha1/GDNF/SHC -0.089 0.184 -9999.0 0.0 -0.306 192.0 192.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 RET9/GFRalpha1/GDNF/SHC -0.036 0.125 -9999.0 0.0 -0.239 129.0 129.0 RET9/GFRalpha1/GDNF/Shank3 -0.052 0.139 -9999.0 0.0 -0.238 176.0 176.0 MAPK3 -0.117 0.159 0.193 4.0 -0.303 175.0 179.0 DOK1 0.026 0.062 -9999.0 0.0 -0.429 9.0 9.0 DOK6 0.005 0.108 -9999.0 0.0 -0.429 29.0 29.0 PXN 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 neurite development -0.11 0.162 0.256 2.0 -0.366 107.0 109.0 DOK5 0.012 0.088 -9999.0 0.0 -0.429 19.0 19.0 GFRA1 -0.137 0.217 -9999.0 0.0 -0.429 178.0 178.0 MAPK8 -0.124 0.187 -9999.0 0.0 -0.433 102.0 102.0 HRAS/GTP -0.125 0.225 -9999.0 0.0 -0.357 219.0 219.0 tube development -0.044 0.134 0.224 12.0 -0.226 167.0 179.0 MAPK1 -0.119 0.159 0.192 5.0 -0.387 93.0 98.0 RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.057 0.117 -9999.0 0.0 -0.219 163.0 163.0 Rac1/GDP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.031 0.03 -9999.0 0.0 -0.429 2.0 2.0 PDLIM7 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok6 -0.103 0.209 -9999.0 0.0 -0.318 223.0 223.0 SHC1 0.027 0.025 -9999.0 0.0 -0.429 1.0 1.0 RET51/GFRalpha1/GDNF/Dok4 -0.111 0.198 -9999.0 0.0 -0.319 219.0 219.0 RET51/GFRalpha1/GDNF/Dok5 -0.112 0.203 -9999.0 0.0 -0.326 217.0 217.0 PRKCA 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.023 0.026 -9999.0 0.0 -0.303 3.0 3.0 CREB1 -0.1 0.173 -9999.0 0.0 -0.381 108.0 108.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.043 0.114 -9999.0 0.0 -0.23 122.0 122.0 RET51/GFRalpha1/GDNF/Grb7 -0.097 0.196 -9999.0 0.0 -0.328 190.0 190.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET -0.098 0.202 -9999.0 0.0 -0.429 136.0 136.0 DOK4 0.029 0.024 -9999.0 0.0 -0.429 1.0 1.0 JNK cascade -0.133 0.181 0.193 3.0 -0.413 112.0 115.0 RET9/GFRalpha1/GDNF/FRS2 -0.05 0.139 -9999.0 0.0 -0.239 172.0 172.0 SHANK3 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 RASA1 0.026 0.058 -9999.0 0.0 -0.429 8.0 8.0 NCK1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.041 0.105 -9999.0 0.0 -0.218 123.0 123.0 RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.108 0.179 -9999.0 0.0 -0.303 204.0 204.0 RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.124 0.2 -9999.0 0.0 -0.321 221.0 221.0 RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.121 0.2 -9999.0 0.0 -0.354 180.0 180.0 PI3K -0.162 0.251 0.235 1.0 -0.471 169.0 170.0 SOS1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.038 0.137 -9999.0 0.0 -0.226 167.0 167.0 GRB10 0.021 0.077 -9999.0 0.0 -0.429 14.0 14.0 activation of MAPKK activity -0.087 0.15 -9999.0 0.0 -0.341 93.0 93.0 RET51/GFRalpha1/GDNF/FRS2 -0.106 0.201 -9999.0 0.0 -0.32 216.0 216.0 GAB1 0.026 0.062 -9999.0 0.0 -0.429 9.0 9.0 IRS1 -0.017 0.145 -9999.0 0.0 -0.429 55.0 55.0 IRS2 0.008 0.099 -9999.0 0.0 -0.429 24.0 24.0 RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.123 0.205 -9999.0 0.0 -0.361 182.0 182.0 RET51/GFRalpha1/GDNF/PKC alpha -0.099 0.197 -9999.0 0.0 -0.322 203.0 203.0 GRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GDNF 0.032 0.036 -9999.0 0.0 -0.429 3.0 3.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/IRS1 -0.128 0.232 -9999.0 0.0 -0.357 228.0 228.0 Rac1/GTP -0.126 0.201 0.203 1.0 -0.376 165.0 166.0 RET9/GFRalpha1/GDNF -0.071 0.141 -9999.0 0.0 -0.26 176.0 176.0 GFRalpha1/GDNF -0.086 0.166 -9999.0 0.0 -0.31 176.0 176.0