BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS -0.14 0.168 -9999.0 0.0 -0.52 8.0 8.0 SMAD6-7/SMURF1 0.028 0.051 -9999.0 0.0 -0.369 2.0 2.0 NOG 0.012 0.059 -9999.0 0.0 -0.609 2.0 2.0 SMAD9 -0.107 0.192 -9999.0 0.0 -0.497 34.0 34.0 SMAD4 -0.005 0.116 -9999.0 0.0 -0.609 8.0 8.0 SMAD5 -0.031 0.117 -9999.0 0.0 -0.378 10.0 10.0 BMP7/USAG1 -0.385 0.29 -9999.0 0.0 -0.529 166.0 166.0 SMAD5/SKI -0.021 0.112 -9999.0 0.0 -0.384 6.0 6.0 SMAD1 0.031 0.098 -9999.0 0.0 -0.708 2.0 2.0 BMP2 -0.072 0.215 -9999.0 0.0 -0.587 33.0 33.0 SMAD1/SMAD1/SMAD4 -0.026 0.078 -9999.0 0.0 -0.534 2.0 2.0 BMPR1A 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 BMPR1B 0.011 0.056 -9999.0 0.0 -0.466 3.0 3.0 BMPR1A-1B/BAMBI -0.068 0.163 -9999.0 0.0 -0.369 34.0 34.0 AHSG -0.011 0.129 -9999.0 0.0 -0.609 10.0 10.0 CER1 0.012 0.053 -9999.0 0.0 -0.537 2.0 2.0 BMP2-4/CER1 -0.108 0.208 -9999.0 0.0 -0.414 59.0 59.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.06 0.162 -9999.0 0.0 -0.467 15.0 15.0 BMP2-4 (homodimer) -0.136 0.237 -9999.0 0.0 -0.45 76.0 76.0 RGMB -0.06 0.185 -9999.0 0.0 -0.495 34.0 34.0 BMP6/BMPR2/BMPR1A-1B 0.017 0.091 -9999.0 0.0 -0.327 9.0 9.0 RGMA -0.014 0.131 -9999.0 0.0 -0.561 12.0 12.0 SMURF1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.076 0.159 -9999.0 0.0 -0.412 26.0 26.0 BMP2-4/USAG1 -0.273 0.277 -9999.0 0.0 -0.519 100.0 100.0 SMAD6/SMURF1/SMAD5 -0.021 0.112 -9999.0 0.0 -0.384 6.0 6.0 SOSTDC1 -0.263 0.289 -9999.0 0.0 -0.553 110.0 110.0 BMP7/BMPR2/BMPR1A-1B -0.145 0.167 -9999.0 0.0 -0.337 64.0 64.0 SKI 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) -0.017 0.133 -9999.0 0.0 -0.526 14.0 14.0 HFE2 0.001 0.098 -9999.0 0.0 -0.585 6.0 6.0 ZFYVE16 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 BMP2-4/CHRD -0.105 0.207 -9999.0 0.0 -0.415 58.0 58.0 SMAD5/SMAD5/SMAD4 -0.032 0.127 -9999.0 0.0 -0.42 9.0 9.0 MAPK1 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 TAK1/TAB family -0.073 0.114 -9999.0 0.0 -0.502 7.0 7.0 BMP7 (homodimer) -0.297 0.277 -9999.0 0.0 -0.532 128.0 128.0 NUP214 0.013 0.045 -9999.0 0.0 -0.466 2.0 2.0 BMP6/FETUA -0.019 0.138 -9999.0 0.0 -0.416 23.0 23.0 SMAD1/SKI 0.039 0.094 -9999.0 0.0 -0.662 2.0 2.0 SMAD6 0.008 0.069 -9999.0 0.0 -0.502 4.0 4.0 CTDSP2 0.005 0.085 -9999.0 0.0 -0.552 5.0 5.0 BMP2-4/FETUA -0.122 0.222 -9999.0 0.0 -0.432 64.0 64.0 MAP3K7IP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 -0.119 0.248 -9999.0 0.0 -0.56 53.0 53.0 BMPR2 (homodimer) 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GADD34/PP1CA 0.025 0.055 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B (homodimer) 0.015 0.066 -9999.0 0.0 -0.381 6.0 6.0 CHRDL1 -0.006 0.11 -9999.0 0.0 -0.509 10.0 10.0 ENDOFIN/SMAD1 0.039 0.094 -9999.0 0.0 -0.662 2.0 2.0 SMAD6-7/SMURF1/SMAD1 0.047 0.095 -9999.0 0.0 -0.606 2.0 2.0 SMAD6/SMURF1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAMBI -0.132 0.249 -9999.0 0.0 -0.54 60.0 60.0 SMURF2 -0.005 0.106 -9999.0 0.0 -0.495 10.0 10.0 BMP2-4/CHRDL1 -0.119 0.218 -9999.0 0.0 -0.431 60.0 60.0 BMP2-4/GREM1 -0.188 0.246 -9999.0 0.0 -0.451 89.0 89.0 SMAD7 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 SMAD8A/SMAD8A/SMAD4 -0.104 0.193 -9999.0 0.0 -0.485 36.0 36.0 SMAD1/SMAD6 0.039 0.094 -9999.0 0.0 -0.662 2.0 2.0 TAK1/SMAD6 0.024 0.031 -9999.0 0.0 -0.441 1.0 1.0 BMP7 -0.297 0.278 -9999.0 0.0 -0.533 128.0 128.0 BMP6 -0.017 0.133 -9999.0 0.0 -0.527 14.0 14.0 MAP3K7IP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.056 0.145 -9999.0 0.0 -0.387 20.0 20.0 PPM1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 0.028 0.111 -9999.0 0.0 -0.584 4.0 4.0 SMAD7/SMURF1 0.024 0.031 -9999.0 0.0 -0.441 1.0 1.0 CTDSPL -0.009 0.121 -9999.0 0.0 -0.566 10.0 10.0 PPP1CA 0.007 0.071 -9999.0 0.0 -0.466 5.0 5.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.011 0.056 -9999.0 0.0 -0.466 3.0 3.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.075 0.163 -9999.0 0.0 -0.391 31.0 31.0 CHRD 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM -0.08 0.169 -9999.0 0.0 -0.439 26.0 26.0 BMP4 -0.117 0.246 -9999.0 0.0 -0.559 52.0 52.0 FST -0.007 0.117 -9999.0 0.0 -0.577 9.0 9.0 BMP2-4/NOG -0.108 0.208 -9999.0 0.0 -0.413 60.0 60.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.128 0.158 -9999.0 0.0 -0.501 3.0 3.0