Caspase cascade in apoptosis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TOP1 -0.024 0.138 0.242 1.0 -0.329 24.0 25.0 ACTA1 -0.047 0.165 0.256 3.0 -0.408 27.0 30.0 NUMA1 -0.024 0.138 0.242 1.0 -0.334 22.0 23.0 SPTAN1 -0.038 0.166 0.279 1.0 -0.418 25.0 26.0 LIMK1 -0.066 0.189 0.254 3.0 -0.415 37.0 40.0 BIRC3 -0.061 0.19 -9999.0 0.0 -0.513 33.0 33.0 BIRC2 0.015 0.032 -9999.0 0.0 -0.467 1.0 1.0 BAX 0.006 0.076 -9999.0 0.0 -0.495 5.0 5.0 CASP10 -0.071 0.177 -9999.0 0.0 -0.407 34.0 34.0 CRMA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 -0.023 0.138 0.242 1.0 -0.331 23.0 24.0 DIABLO 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptotic nuclear changes -0.037 0.163 0.26 2.0 -0.411 25.0 27.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.006 0.083 -9999.0 0.0 -0.609 4.0 4.0 GSN -0.056 0.174 0.255 3.0 -0.409 30.0 33.0 MADD 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TFAP2A -0.004 0.106 -9999.0 0.0 -0.617 4.0 4.0 BID -0.031 0.103 -9999.0 0.0 -0.229 34.0 34.0 MAP3K1 -0.007 0.068 -9999.0 0.0 -0.257 3.0 3.0 TRADD 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 -0.005 0.116 -9999.0 0.0 -0.413 16.0 16.0 mol:Activated DNA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIB -0.055 0.184 0.254 3.0 -0.429 32.0 35.0 CASP9 0.012 0.059 -9999.0 0.0 -0.608 2.0 2.0 DNA repair -0.007 0.068 0.287 2.0 -0.215 4.0 6.0 neuron apoptosis -0.013 0.158 -9999.0 0.0 -0.68 10.0 10.0 mol:NAD 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA fragmentation during apoptosis -0.03 0.157 0.27 1.0 -0.38 26.0 27.0 APAF1 -0.02 0.141 -9999.0 0.0 -0.542 15.0 15.0 CASP6 -0.006 0.136 -9999.0 0.0 -0.762 4.0 4.0 TRAF2 0.013 0.045 -9999.0 0.0 -0.466 2.0 2.0 ICAD/CAD -0.028 0.156 0.274 1.0 -0.388 24.0 25.0 CASP7 0.034 0.109 0.256 32.0 -0.563 2.0 34.0 KRT18 -0.002 0.085 -9999.0 0.0 -0.532 4.0 4.0 apoptosis -0.04 0.167 0.28 3.0 -0.44 16.0 19.0 DFFA -0.036 0.161 0.279 1.0 -0.405 25.0 26.0 DFFB -0.038 0.161 0.261 2.0 -0.405 25.0 27.0 PARP1 0.007 0.069 0.215 4.0 -0.29 2.0 6.0 actin filament polymerization 0.075 0.192 0.431 34.0 -0.271 1.0 35.0 TNF -0.005 0.106 -9999.0 0.0 -0.495 10.0 10.0 CYCS -0.023 0.084 -9999.0 0.0 -0.262 7.0 7.0 SATB1 -0.077 0.192 -9999.0 0.0 -0.54 15.0 15.0 SLK -0.039 0.164 0.279 1.0 -0.403 27.0 28.0 p15 BID/BAX -0.024 0.102 -9999.0 0.0 -0.322 10.0 10.0 CASP2 0.029 0.074 -9999.0 0.0 -0.367 1.0 1.0 JNK cascade 0.007 0.067 0.255 3.0 -9999.0 0.0 3.0 CASP3 -0.047 0.17 0.265 3.0 -0.436 25.0 28.0 LMNB2 0.021 0.085 -9999.0 0.0 -0.334 5.0 5.0 RIPK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP4 -0.005 0.108 -9999.0 0.0 -0.53 9.0 9.0 Mammalian IAPs/DIABLO -0.012 0.112 -9999.0 0.0 -0.348 12.0 12.0 negative regulation of DNA binding -0.004 0.105 -9999.0 0.0 -0.61 4.0 4.0 stress fiber formation -0.038 0.162 0.26 2.0 -0.397 27.0 29.0 GZMB -0.086 0.189 -9999.0 0.0 -0.384 62.0 62.0 CASP1 -0.09 0.173 -9999.0 0.0 -0.391 43.0 43.0 LMNB1 -0.015 0.124 -9999.0 0.0 -0.424 7.0 7.0 APP -0.013 0.161 -9999.0 0.0 -0.691 10.0 10.0 TNFRSF1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.008 0.054 -9999.0 0.0 -0.453 3.0 3.0 VIM -0.044 0.164 0.279 3.0 -0.434 17.0 20.0 LMNA 0.022 0.083 -9999.0 0.0 -0.342 4.0 4.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.022 0.078 -9999.0 0.0 -0.396 1.0 1.0 LRDD 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 SREBF1 -0.045 0.168 0.279 1.0 -0.397 30.0 31.0 APAF-1/Caspase 9 -0.018 0.107 -9999.0 0.0 -0.71 3.0 3.0 nuclear fragmentation during apoptosis -0.023 0.136 0.241 1.0 -0.329 22.0 23.0 CFL2 -0.078 0.197 0.272 1.0 -0.442 34.0 35.0 GAS2 -0.163 0.226 0.242 1.0 -0.419 78.0 79.0 positive regulation of apoptosis 0.008 0.095 -9999.0 0.0 -0.363 6.0 6.0 PRF1 -0.046 0.166 -9999.0 0.0 -0.476 29.0 29.0