E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.004 0.166 -9999.0 0.0 -0.536 18.0 18.0 KLHL20 -0.04 0.082 -9999.0 0.0 -0.299 8.0 8.0 CYFIP2 -0.016 0.139 -9999.0 0.0 -0.597 12.0 12.0 Rac1/GDP 0.021 0.124 -9999.0 0.0 -0.493 6.0 6.0 ENAH -0.02 0.178 -9999.0 0.0 -0.564 17.0 17.0 AP1M1 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 RAP1B 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 RAP1A 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 CTNNB1 -0.021 0.14 -9999.0 0.0 -0.52 16.0 16.0 CDC42/GTP -0.03 0.088 -9999.0 0.0 -0.425 7.0 7.0 ABI1/Sra1/Nap1 -0.034 0.061 -9999.0 0.0 -0.214 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.024 0.142 -9999.0 0.0 -0.335 32.0 32.0 RAPGEF1 0.011 0.153 -9999.0 0.0 -0.477 17.0 17.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.169 -9999.0 0.0 -0.57 17.0 17.0 CRK 0.002 0.166 -9999.0 0.0 -0.531 17.0 17.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.089 -9999.0 0.0 -0.369 11.0 11.0 alphaE/beta7 Integrin -0.01 0.122 -9999.0 0.0 -0.421 18.0 18.0 IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 -0.005 0.106 -9999.0 0.0 -0.495 10.0 10.0 Rap1/GTP/I-afadin 0.019 0.071 -9999.0 0.0 -0.336 8.0 8.0 DLG1 -0.004 0.166 -9999.0 0.0 -0.546 17.0 17.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.063 -9999.0 0.0 -0.298 7.0 7.0 MLLT4 -0.002 0.109 -9999.0 0.0 -0.609 7.0 7.0 ARF6/GTP/NME1/Tiam1 0.02 0.077 -9999.0 0.0 -0.384 7.0 7.0 PI3K -0.029 0.084 -9999.0 0.0 -0.403 7.0 7.0 ARF6 0.003 0.093 -9999.0 0.0 -0.609 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.001 0.103 -9999.0 0.0 -0.431 12.0 12.0 TIAM1 0.01 0.067 -9999.0 0.0 -0.561 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.004 0.107 -9999.0 0.0 -0.322 17.0 17.0 AKT1 -0.018 0.05 -9999.0 0.0 -0.223 6.0 6.0 PIK3R1 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 CDH1 -0.013 0.135 -9999.0 0.0 -0.609 11.0 11.0 RhoA/GDP 0.02 0.124 -9999.0 0.0 -0.493 6.0 6.0 actin cytoskeleton organization 0.013 0.082 -9999.0 0.0 -0.212 8.0 8.0 CDC42/GDP 0.019 0.126 -9999.0 0.0 -0.476 7.0 7.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.065 -9999.0 0.0 -0.266 11.0 11.0 ITGB7 -0.022 0.152 -9999.0 0.0 -0.609 14.0 14.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.005 0.114 -9999.0 0.0 -0.341 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.006 0.106 -9999.0 0.0 -0.331 17.0 17.0 mol:GDP 0.009 0.144 -9999.0 0.0 -0.61 6.0 6.0 CDC42/GTP/IQGAP1 0.022 0.02 -9999.0 0.0 -0.27 1.0 1.0 JUP 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 p120 catenin/RhoA/GDP 0.017 0.124 -9999.0 0.0 -0.503 6.0 6.0 RAC1/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.024 0.031 -9999.0 0.0 -0.441 1.0 1.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.068 -9999.0 0.0 -0.214 9.0 9.0 NME1 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.004 0.166 -9999.0 0.0 -0.546 17.0 17.0 regulation of cell-cell adhesion -0.026 0.076 -9999.0 0.0 -0.364 7.0 7.0 WASF2 -0.02 0.036 -9999.0 0.0 -0.235 1.0 1.0 Rap1/GTP -0.034 0.1 -9999.0 0.0 -0.503 6.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.007 0.116 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.011 0.082 -9999.0 0.0 -0.269 9.0 9.0 VAV2 -0.057 0.265 -9999.0 0.0 -0.726 25.0 25.0 RAP1/GDP 0.021 0.122 -9999.0 0.0 -0.509 6.0 6.0 adherens junction assembly -0.003 0.16 -9999.0 0.0 -0.526 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.005 0.129 -9999.0 0.0 -0.505 1.0 1.0 E-cadherin/beta catenin -0.024 0.088 -9999.0 0.0 -0.384 12.0 12.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.007 0.177 -9999.0 0.0 -0.579 17.0 17.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.067 0.14 -9999.0 0.0 -0.409 23.0 23.0 E-cadherin/beta catenin/alpha catenin -0.008 0.123 -9999.0 0.0 -0.384 17.0 17.0 ITGAE 0.008 0.069 -9999.0 0.0 -0.502 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.173 -9999.0 0.0 -0.586 17.0 17.0